Best TWAS P=1.52e-08 · Best GWAS P=3.19e-07 conditioned to 0.0132
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | RNF123 | 0.19 | 0.18 | enet | 29 | 0.18 | 2.1e-14 | -4.6 | -5.2 | 1.7e-07 | 0.77 | 0.16 | 0.82 | FALSE |
2 | GTEx | Artery Tibial | IP6K1 | 0.03 | 0.00 | enet | 22 | 0.01 | 2.5e-02 | -4.9 | -5.3 | 1.5e-07 | 0.70 | 0.09 | 0.60 | FALSE |
3 | GTEx | Brain Cerebellum | MST1R | 0.19 | 0.24 | enet | 22 | 0.20 | 1.8e-06 | 4.3 | -5.1 | 2.9e-07 | 0.83 | 0.12 | 0.85 | FALSE |
4 | GTEx | Brain Cerebellum | GPX1 | 0.31 | 0.09 | enet | 19 | 0.23 | 2.0e-07 | 4.8 | -5.4 | 7.8e-08 | 0.43 | 0.04 | 0.94 | FALSE |
5 | GTEx | Brain Frontal Cortex BA9 | GPX1 | 0.16 | 0.06 | lasso | 6 | 0.15 | 7.9e-05 | -4.0 | -5.6 | 2.3e-08 | 0.38 | 0.06 | 0.77 | FALSE |
6 | GTEx | Esophagus Muscularis | GPX1 | 0.13 | 0.05 | lasso | 14 | 0.06 | 1.1e-04 | 4.8 | -5.5 | 3.3e-08 | 0.40 | 0.04 | 0.94 | FALSE |
7 | GTEx | Heart Left Ventricle | DAG1 | 0.06 | 0.02 | enet | 14 | 0.02 | 3.2e-02 | -3.8 | 5.2 | 2.6e-07 | -0.63 | 0.25 | 0.28 | FALSE |
8 | GTEx | Lung | GPX1 | 0.04 | 0.02 | enet | 13 | 0.04 | 5.7e-04 | 4.7 | -5.7 | 1.5e-08 | 0.53 | 0.06 | 0.71 | TRUE |
9 | METSIM | Adipose | MST1R | 0.03 | 0.02 | blup | 331 | 0.02 | 1.7e-03 | -4.8 | -5.5 | 3.9e-08 | 0.88 | 0.05 | 0.94 | FALSE |
10 | ROSMAP | Brain Pre-frontal Cortex | MST1R | 0.02 | 0.00 | blup | 278 | 0.01 | 4.5e-02 | -4.8 | -5.3 | 1.2e-07 | 0.81 | 0.12 | 0.80 | FALSE |
11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | AMIGO3 | 0.01 | 0.00 | enet | 13 | 0.01 | 5.7e-03 | -3.8 | -5.2 | 1.8e-07 | 0.57 | 0.01 | 0.27 | FALSE |
12 | The Cancer Genome Atlas | Lung Adenocarcinoma | AMIGO3 | 0.02 | 0.00 | blup | 40 | 0.00 | 3.0e-01 | -4.6 | -5.1 | 3.1e-07 | 0.70 | 0.01 | 0.60 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | UBA7 | 0.03 | 0.01 | blup | 30 | 0.02 | 2.0e-03 | -4.5 | 5.2 | 2.3e-07 | -0.79 | 0.02 | 0.66 | FALSE |