[Hub]/) : Traits : Medication: Cholesterol lowering : ← →

chr19:18,740,208-20,451,172

Best TWAS P=8.26e-14 · Best GWAS P=9.49e-18 conditioned to 7.22e-06

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Cells Transformed fibroblasts ATP13A1 0.14 0.06 lasso 5 0.05 2.2e-04 -7.4 -7.5 8.3e-14 0.93 0.19 0.56 TRUE
2 GTEx Cells Transformed fibroblasts GATAD2A 0.07 0.00 lasso 4 0.00 8.1e-01 -5.0 -6.8 7.5e-12 0.72 0.07 0.31 FALSE
3 GTEx Muscle Skeletal MAU2 0.09 0.04 lasso 4 0.05 5.1e-06 -4.1 5.2 2.3e-07 -0.59 0.99 0.01 FALSE
4 GTEx Spleen ATP13A1 0.16 0.01 lasso 5 0.02 9.7e-02 -5.0 -5.2 1.6e-07 0.35 0.08 0.07 FALSE
5 GTEx Whole Blood GATAD2A 0.06 0.02 lasso 9 0.03 1.7e-03 -5.0 -5.4 6.4e-08 0.63 0.36 0.53 FALSE
6 ROSMAP Brain Pre-frontal Cortex ATP13A1 0.10 0.07 lasso 5 0.06 1.3e-08 -6.2 6.1 1.2e-09 -0.78 0.14 0.85 FALSE
7 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma HAPLN4 0.05 0.07 lasso 2 0.06 1.1e-07 -5.2 -5.3 9.9e-08 0.48 0.99 0.01 FALSE
8 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TM6SF2 0.04 0.03 blup 35 0.03 2.5e-04 -4.2 -5.2 1.9e-07 0.76 0.22 0.44 FALSE
9 The Cancer Genome Atlas Thyroid Carcinoma HAPLN4 0.08 0.06 blup 37 0.09 1.8e-09 -5.2 -5.3 1.2e-07 0.33 1.00 0.00 FALSE
10 The Cancer Genome Atlas Thyroid Carcinoma KIAA0892 0.04 0.04 blup 43 0.02 4.1e-03 -5.2 5.3 9.8e-08 -0.43 0.53 0.05 FALSE