Best TWAS P=2.13e-09 · Best GWAS P=7.22e-11 conditioned to 0.00544
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | AGBL2 | 0.03 | 0.02 | enet | 7 | 0.03 | 7.9e-05 | -5.9 | -6.0 | 2.1e-09 | 0.70 | 0.26 | 0.72 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | PTPRJ | 0.06 | 0.04 | lasso | 4 | 0.05 | 7.6e-07 | -6.0 | -5.8 | 5.3e-09 | 0.68 | 0.16 | 0.84 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | ACP2 | 0.03 | 0.00 | lasso | 1 | 0.02 | 1.0e-01 | -5.5 | 5.5 | 4.5e-08 | -0.60 | 0.02 | 0.15 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | ACP2 | 0.17 | 0.03 | lasso | 6 | 0.03 | 4.2e-02 | -3.6 | 6.0 | 2.4e-09 | -0.47 | 0.06 | 0.84 | FALSE |
| 5 | GTEx | Esophagus Gastroesophageal Junction | NUP160 | 0.18 | 0.02 | enet | 18 | 0.11 | 7.1e-05 | 3.4 | -5.2 | 2.3e-07 | 0.33 | 0.26 | 0.08 | TRUE |
| 6 | GTEx | Esophagus Mucosa | ACP2 | 0.07 | 0.04 | enet | 11 | 0.04 | 6.2e-04 | -5.5 | 5.6 | 1.8e-08 | -0.43 | 0.02 | 0.97 | TRUE |
| 7 | GTEx | Muscle Skeletal | FNBP4 | 0.05 | 0.03 | lasso | 5 | 0.04 | 5.0e-05 | -5.5 | -5.4 | 7.0e-08 | 0.39 | 0.49 | 0.28 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | SLC39A13 | 0.07 | 0.11 | lasso | 2 | 0.10 | 5.2e-06 | -5.5 | -5.6 | 2.8e-08 | 0.55 | 0.08 | 0.79 | FALSE |
| 9 | METSIM | Adipose | NR1H3 | 0.03 | 0.03 | lasso | 6 | 0.04 | 4.7e-06 | 4.4 | -5.4 | 8.6e-08 | 0.40 | 0.16 | 0.78 | FALSE |
| 10 | NTR | Blood | DDB2 | 0.01 | 0.00 | lasso | 7 | 0.01 | 2.2e-03 | -4.4 | 5.2 | 2.3e-07 | -0.37 | 0.09 | 0.72 | FALSE |