Hub : Genes

TRAF4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0810	0.0230	4.3e-09	0.113	0.094	0.097	0.1	0.110	1.3e-13	1.5e-11	8.6e-12	3.4e-12	3.1e-13
2	GTEx	Cells Transformed fibroblasts	0.0840	0.0300	6.5e-06	0.082	NA	0.096	NA	0.107	9.6e-07	NA	1.1e-07	NA	2.2e-08
3	TCGA	Brain Lower Grade Glioma	0.0378	0.0229	4.6e-03	0.024	0.020	0.005	NA	0.017	9.1e-04	2.1e-03	8.7e-02	NA	4.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.2	0.3	0.8	-0.1	0.1	0.9
Bipolar Disorder or Schizophrenia	0.5	1.3	2.9	1.0	0.2	1.7
Depressed Affect (Nagel 2018)	0.2	0.5	0.8	-0.9	0.1	-0.8
Depression (Nagel 2018)	1.9	2.9	4.8	-2.2	0.5	-1.9
Intelligence (Savage-Jansen 2018)	2.3	7.1	10.7	3.3	-0.9	3.1
Neuroticism (Nagel 2018)	1.1	2.7	3.7	-1.9	-0.9	-1.9
Schizophrenia (2018)	0.7	1.4	2.1	1.4	0.2	1.4
Schizophrenia vs Biploar Disorder	0.3	0.4	0.8	0.4	0.9	-0.3
Worry (Nagel 2018)	1.2	2.4	4.6	-2.1	-0.1	-1.6
Alzheimer’s Disease (in mother)	1.1	1.3	2.0	0.8	-1.4	1.2
Alzheimer’s Disease (in father)	0.1	0.2	0.4	0.3	0.6	0.1
Alzheimer’s Disease (including proxy)	1.0	1.4	2.3	1.2	-0.7	1.5
Crohns Disease (2017)	0.2	0.4	0.8	-0.6	0.9	-0.2
Irritable Bowel Disease (IBD)	0.2	0.5	0.8	-0.8	0.9	0.1
Ulcerative Colitis (UC)	0.2	0.3	0.8	-0.1	0.2	0.9
Major Depression (MDD)	1.3	1.6	2.1	-1.4	1.4	-0.8
Reaction Time	3.5	6.7	11.8	3.4	-1.1	2.6
Verbal and Numeric Reasoning (VNR)	3.2	7.6	9.4	3.0	-2.2	3.1
Breast Cancer	0.5	1.2	3.2	0.0	1.8	0.6
Ovarian Cancer	0.9	1.2	2.0	-1.1	1.4	-0.7
Prostate Cancer	0.1	0.2	0.4	-0.6	-0.3	-0.3
Age at First Birth	0.4	0.6	1.6	0.5	-1.3	0.3
Bipolar Disorder (2011)	1.3	1.3	3.2	-0.8	1.8	0.1
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	0.3	0.5	0.0
Coronary Artery Disease (CAD)	0.6	0.8	1.7	0.8	0.0	1.3
Crohns Disease (2012)	0.1	0.2	0.3	0.1	-0.6	0.6
Mean Putamen Volume	4.0	4.5	7.4	-2.7	1.7	-1.8
Fasting Glucose	0.9	1.1	1.2	-1.1	1.0	-1.1
HbA1C	6.8	7.5	8.8	-3.0	2.9	-2.3
HDL Cholesterol	0.3	0.5	1.2	0.5	-0.3	1.1
LDL Cholesterol	5.6	8.8	13.1	-3.1	3.6	-1.9
Lupus	0.2	0.2	0.4	0.6	-0.5	0.3
Neuroticism (2016)	0.9	1.3	2.5	-1.6	0.4	-1.1
Primary Biliary Cirrhosis	0.0	0.0	0.0	0.0	-0.2	-0.2
Rheumatoid Arthritis	0.4	0.5	0.9	0.9	-0.4	0.7
Schizophrenia (2014)	0.2	0.4	0.8	0.4	0.3	0.9
Triglycerides	0.3	0.5	0.8	-0.9	0.0	-0.9
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.2	-0.6	0.4	-1.1
Ulcerative Colitis	0.5	0.7	1.9	-0.1	0.5	1.4
Blood Eosinophil Count	0.4	3.3	4.5	2.1	-1.6	1.7
Blood Platelet Count	2.3	26.8	36.8	3.1	5.8	6.1
Blood Red Count	8.6	82.6	106.1	-8.7	10.3	-8.2
Blood White Count	0.9	6.8	8.2	2.3	-2.6	2.9
Heel T-Score	1.1	9.0	12.9	-3.0	-2.3	-3.6
BMI	2.7	15.6	29.6	-3.3	5.4	-2.5
Height	0.2	4.6	10.6	-1.3	-1.2	-3.3
Waist Hip Ratio (WHR)	0.6	2.6	5.7	0.7	2.4	1.2
Systolic Blood Pressure	0.3	1.3	1.3	-1.1	1.1	-1.1
Smoking Status	2.4	5.8	10.0	-2.2	3.2	-1.7
Allergy or Eczema	1.3	3.5	6.1	2.5	-1.4	1.5
Cardiovascular Disease	2.6	8.7	15.4	-2.5	3.9	-2.1
Hypothyroidism (self reported)	0.3	0.6	1.8	-0.0	-1.3	-0.2
Respiratory disease	2.0	4.6	9.8	1.7	-3.1	1.1
Type 2 Diabetes (T2D) (2018)	0.7	1.4	2.5	1.1	0.6	1.6
Lung FEV1/FVC ratio	0.0	0.2	0.5	-0.4	0.7	-0.2
Lung FVC	0.4	2.2	5.1	-1.2	-0.5	-2.2
Neuroticism	0.5	1.2	2.1	-1.5	-0.2	-1.2
Chronotype (morning person)	2.7	6.2	9.9	-2.5	1.5	-3.1
Hair Pigment	0.0	0.4	0.9	0.3	0.9	0.4
Tanning	0.0	0.2	0.3	-0.5	0.3	-0.4
Hand grip strength (left)	0.9	2.4	3.3	-1.8	1.1	-1.6
Number of treatments/medications taken	0.8	1.4	3.0	-0.9	1.7	-0.7
Average weekly spirits intake	0.2	0.3	0.5	0.5	-0.7	0.3
Sensitivity / hurt feelings	0.9	1.5	2.0	-0.9	-1.3	-1.4
Frequency of depressed mood in last 2 weeks	2.0	2.8	4.1	-2.0	0.7	-2.0
Hearing difficulty/problems: Yes	3.1	4.8	7.0	2.2	-1.5	2.6
Relative age of first facial hair	1.2	2.5	4.0	-1.4	1.2	-2.0
Other serious medical condition/disability diagnosed by doctor	4.1	5.3	8.5	-2.6	0.8	-2.9
Ever used hormone-replacement therapy (HRT)	2.5	3.1	8.9	0.7	-3.0	0.1
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	-0.6	-0.0	-0.4
Systolic blood pressure, automated reading	0.7	1.9	3.5	-1.3	1.9	-0.8
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.6	-0.8	-0.3	-1.3
Angina	2.2	2.9	3.5	-1.7	1.9	-1.5
Medication for hormone replacement therapy	1.3	1.5	2.2	-1.5	-0.6	-1.4
Vitamin and mineral supplements	0.0	0.0	0.1	-0.0	0.3	-0.0
Supplements: Zinc	1.1	1.2	2.3	-1.0	0.4	-1.5
Medication: Co-codamol	1.2	1.4	2.4	-0.9	1.5	-0.9
Medication: Metformin	0.7	1.0	2.1	1.0	-0.0	1.4
Diabetes (father)	0.2	0.3	0.4	-0.6	-0.4	-0.5
Diabetes (mother)	0.3	0.4	1.0	-0.3	1.0	-0.1
Severe depression (siblings)	3.4	3.8	9.2	-1.2	3.0	-0.8
Pack years adult smoking proportion	0.4	0.7	1.7	-0.5	1.3	0.0
Impedance of leg (right)	0.1	0.6	0.9	1.0	-0.4	0.9
Leg fat-free mass (left)	0.5	2.5	3.2	-1.4	1.5	-1.8
Trunk fat percentage	0.4	1.7	4.8	-0.1	2.2	0.4
Hand grip strength (right)	1.1	2.9	3.8	-1.9	1.1	-2.0
Townsend deprivation index at recruitment	1.7	2.5	5.5	0.6	2.4	1.2
Current tobacco smoking	0.9	1.5	4.1	-0.5	2.0	-0.2
Average weekly fortified wine intake	0.9	1.0	1.4	-0.8	-1.0	-1.2
Maternal smoking around birth	0.2	0.3	0.8	-0.4	-0.1	-0.9
Fed-up feelings	0.3	0.5	1.0	1.0	-0.5	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.0	-1.0	0.6	-1.0
Relative age voice broke	0.3	0.5	1.1	-0.5	-0.2	-1.1
Taking other prescription medications	0.4	0.6	1.3	-0.3	-1.1	-0.7
Age when periods started (menarche)	0.6	1.5	2.3	1.3	0.7	1.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.4	-0.5	-1.2	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	5.2	-1.4	-0.5	-2.3
Tinnitus: Yes, but not now, but have in the past	8.8	9.4	11.4	-3.4	2.5	-3.2
Qualifications: CSEs or equivalent	1.2	1.6	1.9	-1.1	1.3	-1.4
Serious illness, injury or assault to yourself	5.4	6.6	10.6	-3.0	0.5	-3.3
High blood pressure	0.8	2.3	4.9	-1.1	2.2	-0.8
Hayfever, allergic rhinitis or eczema	2.2	4.9	7.8	2.8	-1.5	2.1
Multivitamins +/- minerals	0.8	1.1	2.6	0.6	-1.6	0.3
Stomach or abdominal pain in last month	1.3	1.6	2.3	-1.5	0.6	-1.4
Supplements: Glucosamine	0.3	0.4	0.7	-0.6	0.8	-0.2
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	0.8	-0.7	-0.7	-0.9
Medication: Atenolol	4.6	5.8	7.8	-2.5	2.8	-1.9
Medication: Levothyroxine sodium	0.3	0.5	0.7	0.7	-0.5	0.8
Sitting height	0.5	3.8	8.0	0.4	-2.8	-1.8
Chronic bronchitis/emphysema (father)	0.9	1.1	2.5	0.6	1.6	0.7
High blood pressure (mother)	1.0	1.4	3.8	-0.6	1.9	-0.2
Body mass index (BMI)	1.5	6.4	12.3	-2.2	3.5	-1.5
Impedance of leg (left)	0.1	0.6	0.9	1.0	-0.5	0.8
Leg predicted mass (left)	0.5	2.4	3.0	-1.4	1.5	-1.7
Trunk fat mass	0.6	2.5	6.6	-0.8	2.6	-0.5
Waist circumference	2.2	8.2	20.4	-1.7	4.5	-1.2
Number of incorrect matches in round	3.0	5.0	5.5	-2.3	2.3	-2.1
Past tobacco smoking	1.8	3.2	6.1	1.6	-2.5	1.1
Alcohol usually taken with meals	1.5	2.5	4.9	-2.2	0.7	-1.4
Nervous feelings	0.0	0.1	0.1	0.1	0.4	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.7	-0.4	1.3	-0.3
Hearing difficulty/problems with background noise	0.2	0.3	0.8	0.2	0.9	-0.3
Hair/balding pattern: Pattern 2	0.6	0.8	2.1	0.0	-1.4	0.4
Had menopause	0.4	0.5	0.9	-1.0	0.1	-0.7
Had other major operations	0.6	0.7	1.6	-0.6	-0.1	-1.3
Forced vital capacity (FVC)	0.5	1.9	4.5	0.6	-2.1	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.1	6.4	-1.6	-0.5	-2.5
Ever unenthusiastic/disinterested for a whole week	2.4	3.0	8.5	-0.5	2.9	0.4
Qualifications: None of the above	0.1	0.2	0.4	-0.2	0.6	-0.4
Financial difficulties in last 2 years	0.0	0.0	0.1	-0.3	-0.1	-0.2
Mouth/teeth dental problems	3.6	5.6	10.9	1.8	-3.3	1.7
Heart attack	3.9	5.0	6.1	-2.4	2.5	-1.8
Allergy	2.1	4.8	8.4	-2.9	1.1	-2.2
Pain all over the body in last month	0.5	0.6	1.0	-1.0	-0.3	-0.8
Diabetes (self-reported)	0.3	0.4	0.8	0.7	0.2	0.9
Hayfever/allergic rhinitis (self-reported)	3.6	4.8	7.4	2.7	-1.5	2.2
Medication: Ramipril	1.1	1.4	3.9	-0.2	2.0	-0.5
Medication: Simvastatin	3.7	5.4	10.6	-2.3	3.2	-0.7
Fluid intelligence score	0.7	1.4	2.0	1.0	-1.4	1.0
Illnesses of siblings	4.8	6.8	8.3	2.9	-2.7	2.2
Neuroticism score	0.2	0.4	0.5	-0.6	0.5	-0.7
Weight	1.2	6.1	9.5	-2.1	3.1	-2.1
Impedance of arm (right)	4.1	19.2	22.3	4.7	-4.2	4.2
Arm fat percentage (right)	0.6	2.2	6.4	-0.3	2.5	0.2
Trunk fat-free mass	1.7	9.6	12.8	-3.0	2.6	-3.6
Hip circumference	1.1	4.7	9.9	-1.5	3.2	-1.4
Time employed in main current job	0.3	0.3	0.4	-0.4	-0.6	0.5
Alcohol intake versus 10 years previously	0.8	1.1	2.0	-0.6	1.4	-1.0
Father’s age at death	1.7	2.3	5.3	0.8	-2.3	1.0
Worrier / anxious feelings	3.1	5.9	8.4	-2.9	1.4	-2.7
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.3	-0.7	1.5	-0.5
Falls in the last year	0.7	0.9	2.2	-0.1	1.5	-0.8
Hair/balding pattern: Pattern 3	0.5	0.8	1.8	-0.7	1.3	-0.3
Number of live births	0.7	1.1	2.1	-1.0	-0.4	-1.4
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	4.1	0.4	-2.0	-1.1
Pulse rate	2.5	4.2	4.5	2.0	-2.1	1.9
Happiness	0.1	0.2	0.3	-0.5	0.1	-0.5
Noisy workplace	0.2	0.2	0.4	-0.3	0.4	-0.7
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.0	-0.1	1.0	0.4
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	2.0	-1.1	0.7	-1.4
Mouth/teeth dental problems: Dentures	0.8	1.4	2.0	1.4	0.6	1.4
Asthma	1.3	2.6	5.8	1.1	-2.4	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.2	0.5	-0.3	0.4
Medication: Cholesterol lowering	2.9	4.5	10.9	-1.6	3.3	-0.6
Depression (self-reported)	0.4	0.5	0.9	0.6	-0.9	0.6
Medication: Lansoprazole	1.8	2.1	3.1	1.6	-0.6	1.8
Prospective memory result	1.9	2.3	5.8	-0.8	2.4	-0.6
Lung cancer (father)	1.0	1.2	1.7	1.2	0.5	1.3
Illnesses of mother	1.3	1.6	2.7	1.2	-1.6	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	6.2	0.8	-2.5	-1.0
Pulse wave Arterial Stiffness index	0.2	0.3	0.3	0.4	-0.6	0.6
Impedance of arm (left)	3.6	16.6	19.2	4.4	-3.8	4.0
Arm fat mass (right)	1.0	3.9	8.8	-1.4	3.0	-1.0
Trunk predicted mass	1.6	9.1	12.1	-2.9	2.6	-3.5
Standing height	0.1	0.7	1.3	0.5	-0.8	-1.1
Length of working week for main job	0.2	0.2	0.3	-0.6	-0.4	-0.3
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.2	-0.4	-0.5
Breastfed as a baby	0.1	0.2	0.4	0.4	0.6	0.1
Tense / ‘highly strung’	2.1	3.6	6.1	-2.5	0.4	-2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	2.3	-1.5	1.5	-1.2
Hair/balding pattern: Pattern 4	0.2	0.4	1.2	0.2	1.1	0.1
Birth weight of first child	0.2	0.3	0.5	0.6	-0.7	0.2
Peak expiratory flow (PEF)	2.3	5.3	9.5	-2.5	0.7	-3.1
Pulse wave reflection index	1.1	1.3	1.7	-1.3	1.2	-0.8
Ever highly irritable/argumentative for 2 days	2.3	2.8	4.7	1.9	-0.1	2.2
Loud music exposure frequency	0.5	0.6	1.5	0.1	1.2	-0.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	0.3	0.5	0.4
Mouth/teeth dental problems: Bleeding gums	8.8	11.4	14.9	-3.5	3.9	-2.6
Blood clot in the leg (DVT)	0.8	1.1	2.2	1.5	-0.4	1.0
Medication: Paracetamol	0.1	0.2	0.5	-0.2	0.7	-0.1
Headache pain in last month	0.7	1.2	2.6	-0.7	-0.8	-1.6
Medication for cholesterol, blood pressure or diabetes	2.0	3.4	9.0	1.1	-3.0	0.3
Glaucoma (self-reported)	0.3	0.3	0.4	0.6	0.6	0.5
Gout (self-reported)	0.1	0.1	0.2	0.4	-0.3	0.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	0.9	0.7	-1.0	0.8
Medication: Amlodipine	2.6	3.7	5.1	-2.2	1.0	-2.2
Medication: Ventolin 100micrograms inhaler	1.4	1.8	2.8	1.7	-1.0	1.3
Birth weight	0.4	0.8	2.3	0.2	-1.5	-0.0
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.3	-0.9	1.5	-0.7
High blood pressure (siblings)	0.6	0.9	1.6	-1.0	1.3	-0.2
Forced vital capacity (FVC), Best measure	0.9	3.2	7.4	1.4	-2.7	-0.6
Body fat percentage	0.7	2.9	8.2	-0.7	2.9	-0.1
Leg fat percentage (right)	2.5	9.2	18.1	-2.6	4.3	-1.7
Arm fat-free mass (right)	2.2	11.4	13.5	-3.4	3.0	-3.7
Exposure to tobacco smoke outside home	0.6	0.8	1.6	-0.6	0.6	-1.3
Comparative body size at age 10	0.6	1.7	5.2	0.2	-2.3	0.0
Number of full brothers	0.4	0.5	1.4	-0.3	-0.3	-1.2
Worry too long after embarrassment	1.0	1.7	3.1	-0.2	-1.8	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.6	-0.1	0.3	-0.8
Wheeze or whistling in the chest in last year	0.9	1.7	4.0	-0.9	2.0	-0.4
Number of children fathered	2.2	2.5	7.4	0.0	-2.7	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	-0.6	-0.4	-0.3
Age at first live birth	1.3	2.3	4.1	-2.0	0.2	-1.7
Pulse wave peak to peak time	0.1	0.1	0.2	-0.2	0.2	-0.4
Health satisfaction	1.0	1.4	1.7	-1.3	1.3	-0.8
Shortness of breath walking on level ground	4.6	5.4	7.0	-2.6	2.0	-2.3
Qualifications: College or University degree	0.0	0.1	0.3	0.5	-0.0	0.3
Eye problems/disorders: None of the above	0.8	0.9	1.6	0.8	-1.3	0.8
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.2	-1.0	1.5	-0.8
Emphysema/chronic bronchitis	1.7	1.9	3.5	1.9	0.3	1.5
Medication for pain relief, constipation, heartburn	0.1	0.2	0.5	0.2	-0.7	0.1
Neck or shoulder pain in last month	0.4	0.5	1.0	-0.5	1.0	-0.7
Medication: Blood pressure	1.4	2.5	5.8	-1.0	2.4	-0.8
Angina (self-reported)	2.2	2.9	3.2	-1.7	1.8	-1.5
Migraine (self-reported)	0.2	0.2	0.4	-0.1	-0.7	-0.4
Medication: Ibuprofen	0.1	0.1	0.1	0.3	0.3	0.2
Medication: Allopurinol	0.3	0.3	0.9	-0.3	-0.1	-1.0
Medication: Omeprazole	0.4	0.4	0.8	-0.6	-0.9	-0.3
Medication: Seretide 50 evohaler	0.9	1.0	1.2	1.1	-0.9	0.9
Mean time to correctly identify matches	3.0	5.8	9.7	3.1	-0.4	2.7
Heart disease (mother)	4.1	4.9	8.7	-2.3	0.9	-2.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.6	-0.8	1.3	0.2
Whole body fat mass	1.2	4.8	11.2	-1.5	3.4	-1.1
Leg fat mass (right)	2.5	9.7	17.5	-2.7	4.2	-2.1
Arm predicted mass (right)	2.3	11.8	13.6	-3.4	3.2	-3.7
Pulse rate, automated reading	1.2	3.8	4.5	1.9	-2.1	1.9
Alcohol intake frequency.	0.4	0.8	2.3	-0.2	1.5	-0.3
Comparative height size at age 10	0.2	1.0	1.4	1.2	-1.1	0.7
Number of full sisters	3.5	4.3	5.9	2.4	-1.9	1.8
Suffer from ‘nerves’	0.3	0.5	1.3	-0.4	-1.1	-0.1
Overall health rating	0.6	1.4	3.5	-0.8	1.9	-0.1
Chest pain or discomfort	1.1	1.6	2.6	-1.6	1.4	-0.3
Had major operations	0.8	0.9	1.7	-0.8	0.6	-1.3
Age at last live birth	1.6	2.4	4.0	-2.0	0.5	-1.7
Family relationship satisfaction	0.8	1.0	2.3	-0.8	1.5	-0.1
Leg pain on walking	0.9	1.2	2.7	0.2	1.6	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.0	-0.6	0.2	-1.0
Commuting to job workplace: Car/motor vehicle	1.6	1.9	3.7	-1.2	-0.6	-1.9
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.8	-0.4	1.3	0.0
Medication: Aspirin	0.9	1.2	2.2	-1.5	0.7	-1.0
Supplements: Vitamin C	0.8	1.0	2.2	-1.5	0.1	-0.8
Knee pain experienced in last month	0.5	0.9	1.4	-1.0	0.3	-1.2
Hypertension (Self-reported)	1.1	3.2	5.1	-1.7	2.3	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	0.4	-0.6	0.4
Illnesses of father: Heart disease	1.1	1.5	2.6	-1.6	0.8	-1.1
Illnesses of siblings: Diabetes	0.2	0.2	0.5	-0.7	-0.1	-0.3
Smoking status: Previous	0.9	1.4	2.2	-1.2	1.5	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.2	0.5	0.3	0.2
Whole body fat-free mass	1.2	7.0	9.2	-2.5	2.3	-3.0
Leg fat-free mass (right)	0.4	2.0	3.1	-1.2	1.1	-1.8
Arm fat percentage (left)	0.6	2.4	6.9	-0.5	2.6	0.2
Average weekly red wine intake	0.4	0.6	1.2	-1.1	-0.8	-0.1
Handedness (chirality/laterality): Left-handed	1.1	1.4	1.9	1.4	-1.2	0.8
Mood swings	0.6	1.0	1.6	-1.3	0.4	-1.2
Loneliness, isolation	0.1	0.2	0.4	0.1	0.6	0.3
Long-standing illness, disability or infirmity	2.9	4.4	6.3	-2.5	1.3	-2.2
Ever had bowel cancer screening	0.5	0.6	0.8	-0.8	0.6	-0.9
Diabetes diagnosed by doctor	0.8	1.4	2.5	1.2	-0.1	1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.3	3.1	-0.7	1.8	-0.6
Friendships satisfaction	0.1	0.1	0.1	-0.3	0.1	-0.4
Qualifications: nursing, teaching	0.5	0.8	2.4	-0.0	-1.6	-0.3
Commuting to job workplace: Walk	0.7	0.7	1.3	1.1	-0.3	0.9
Eye problems/disorders: Cataract	0.2	0.2	0.4	-0.3	0.7	0.4
Mouth/teeth dental problems: Mouth ulcers	1.8	2.8	3.9	-1.9	0.9	-2.0
Medication for cholesterol	1.0	1.5	2.0	1.4	-1.4	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.5	1.2	-0.1	0.3
Back pain experienced in last month	0.5	0.7	1.9	0.3	-1.4	-0.3
Mineral and other dietary supplements	0.3	0.4	0.6	0.5	0.8	0.4
Breast cancer (self-reported)	2.3	2.8	4.0	-1.4	2.0	-1.5
Asthma (self-reported)	1.8	3.6	7.2	1.5	-2.7	1.1
Osteoporosis (self-reported)	1.1	1.3	2.0	1.4	0.3	1.4
Osteoarthritis (self-reported)	0.3	0.4	1.0	-0.4	1.0	-0.1
Medication: Aspirin	1.3	1.6	3.0	-1.7	0.7	-1.2
Medication: Gliclazide	1.3	1.4	3.8	-0.7	1.9	0.2
Illnesses of father: None of the above (group 1)	0.1	0.1	0.1	-0.3	-0.4	-0.4
Smoking status: Current	1.0	1.5	3.7	-0.9	1.9	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.6	0.6	-1.6	-0.3
Whole body water mass	1.3	7.2	9.1	-2.6	2.4	-3.0
Leg predicted mass (right)	0.3	1.8	2.7	-1.2	1.1	-1.6
Arm fat mass (left)	1.0	4.3	10.0	-1.4	3.2	-0.9
Number of self-reported non-cancer illnesses	0.2	0.4	0.6	-0.5	0.7	-0.7
Average weekly champagne plus white wine intake	1.8	2.4	2.6	-1.6	1.6	-1.5
Miserableness	0.4	0.7	1.0	-0.5	1.0	-0.9
Guilty feelings	2.2	3.3	6.3	-1.7	0.7	-2.5
Wears glasses or contact lenses	1.4	1.6	2.3	1.5	-1.1	1.1
Ever taken oral contraceptive pill	1.3	1.5	3.4	-0.7	1.8	-0.7
Hearing aid user	0.2	0.2	0.4	0.6	-0.5	0.2
Mother’s age at death	0.7	0.9	1.9	0.8	0.4	1.4
Financial situation satisfaction	0.0	0.0	0.0	0.1	-0.1	0.1
Tinnitus: Yes, now most or all of the time	0.8	1.0	1.7	0.8	-1.3	0.8
Commuting to job workplace: Public transport	0.7	0.9	1.2	0.6	1.0	1.1
Eye problems/disorders: Glaucoma	0.1	0.2	0.3	0.4	0.5	-0.3
Medication: Blood pressure	2.1	4.0	5.2	-2.3	1.8	-1.9
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.6	-0.1	-0.7	-0.2
Supplements: Fish oil (including cod liver oil)	1.3	1.6	4.6	0.5	-2.1	0.2
High cholesterol (Self-reported)	1.9	3.3	8.0	-1.4	2.8	0.1
Medication: Bendroflumethiazide	0.3	0.4	0.8	-0.6	0.9	-0.1
Medication: Paracetamol	0.1	0.2	0.4	-0.1	0.6	-0.2
Medication: Lisinopril	0.6	0.8	1.6	-1.3	0.1	-0.9
Medication: Atorvastatin	0.3	0.4	0.8	0.2	0.9	0.6
Illnesses of father: High blood pressure	0.9	1.1	2.1	-1.5	0.1	-1.1
Alcohol drinker status: Never	0.1	0.1	0.1	-0.2	0.4	-0.3
Ever smoked	1.5	2.6	4.0	-1.5	2.0	-1.3
Basal metabolic rate	1.3	7.1	8.3	-2.5	2.6	-2.9
Leg fat percentage (left)	2.3	8.2	16.2	-2.4	4.0	-1.6
Arm fat-free mass (left)	2.1	10.6	12.1	-3.2	3.1	-3.5
Number of operations (self-reported)	0.1	0.1	0.3	0.0	-0.1	-0.5
Average weekly beer plus cider intake	0.5	0.7	1.1	-0.3	-0.9	-1.0
Irritability	0.3	0.5	1.1	-0.6	1.0	-0.5
Risk taking	0.2	0.3	0.7	-0.3	-0.8	0.1
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.3	0.0	-1.2	0.0
Fractured/broken bones in last 5 years	1.9	2.5	3.4	1.8	0.8	1.8
Age started oral contraceptive pill	1.1	1.3	2.2	-1.2	1.5	-0.6
Diastolic blood pressure, automated reading	0.9	2.7	4.8	2.2	-0.8	1.7
Ever depressed for a whole week	1.2	1.5	4.2	-0.2	2.1	0.5
Unable to work because of sickness or disability	0.6	0.8	1.2	-1.0	0.5	-1.1
Commuting to job workplace: Cycle	0.6	0.8	1.3	0.9	0.5	1.1
Myopia	1.1	1.6	1.8	-1.4	1.2	-1.2
Vascular/heart problems diagnosed by doctor	1.5	4.2	7.3	1.8	-2.7	1.4
Cholesterol lowering medication	2.0	3.0	6.8	-1.4	2.6	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.2	0.6	-1.1	0.9
Pain experienced in last month	0.3	0.6	1.2	0.6	0.3	1.1
Supplements: Calcium	0.2	0.2	0.4	-0.0	0.6	0.6
Basal cell carcinoma (self-reported)	0.2	0.3	0.5	-0.7	0.3	-0.5
Heart attack/myocardial infarction (self-reported)	2.8	3.6	4.6	-2.1	2.1	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.2	1.5	-0.5	1.0
Heart disease (siblings)	11.5	14.1	14.7	-3.8	3.8	-3.6
Alcohol drinker status: Previous	0.5	0.5	1.4	0.4	-1.2	-0.0
Pack years of smoking	0.6	0.8	2.0	-0.7	1.4	0.0
Impedance of whole body	2.1	10.5	12.7	3.6	-2.9	3.2
Leg fat mass (left)	2.3	9.1	16.0	-2.6	4.0	-2.1
Arm predicted mass (left)	2.7	13.8	15.3	-3.7	3.5	-3.9