[Hub]/) : Traits : Cardiovascular Disease :

chr16:68,467,643-72,845,749

Best TWAS P=2.18e-12 · Best GWAS P=2.12e-12 conditioned to 0.0011

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex DHX38 0.31 0.39 enet 41 0.41 3.2e-54 5.0 5.4 6.2e-08 0.48 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex HPR 0.72 0.60 lasso 7 0.61 6.9e-94 6.9 6.9 4.2e-12 0.74 0.00 1.00 FALSE
3 CommonMind Brain Pre-frontal Cortex TXNL4B 0.05 0.07 lasso 3 0.06 8.8e-08 6.9 6.4 1.7e-10 0.78 0.00 1.00 FALSE
4 GTEx Adrenal Gland PDXDC2P 0.26 0.17 lasso 4 0.13 2.2e-05 4.8 -5.2 1.8e-07 -0.01 0.01 0.93 FALSE
5 GTEx Brain Cerebellum PDPR 0.23 0.06 enet 20 0.11 3.7e-04 -4.0 -5.2 1.6e-07 0.04 0.05 0.28 FALSE
6 GTEx Brain Cortex DHODH 0.21 0.06 enet 14 0.05 1.5e-02 5.0 6.1 1.2e-09 0.65 0.03 0.74 FALSE
7 GTEx Brain Cortex CIRH1A 0.49 0.29 enet 22 0.30 4.7e-09 -3.6 5.2 2.5e-07 -0.01 0.09 0.50 TRUE
8 GTEx Colon Sigmoid PDXDC2P 0.30 0.16 enet 13 0.14 8.8e-06 4.5 -5.4 5.5e-08 0.00 0.03 0.94 FALSE
9 GTEx Esophagus Muscularis DHX38 0.09 0.07 lasso 7 0.05 4.2e-04 5.5 6.0 1.4e-09 0.64 0.31 0.53 FALSE
10 GTEx Liver PDXDC2P 0.20 0.18 enet 8 0.13 1.5e-04 -4.9 -5.3 1.4e-07 0.04 0.01 0.95 FALSE
11 GTEx Ovary COG4 0.15 0.20 lasso 2 0.15 1.4e-04 5.1 -5.1 2.8e-07 -0.03 0.01 0.78 FALSE
12 GTEx Ovary IST1 0.31 0.03 enet 37 0.07 1.0e-02 -2.7 -6.0 2.7e-09 -0.35 0.08 0.08 FALSE
13 GTEx Skin Not Sun Exposed Suprapubic SF3B3 0.11 0.14 enet 6 0.12 2.5e-07 -5.3 5.4 6.1e-08 -0.06 0.00 1.00 TRUE
14 GTEx Thyroid PDXDC2P 0.41 0.27 lasso 10 0.30 5.0e-23 4.8 -5.2 2.7e-07 0.00 0.01 0.98 FALSE
15 GTEx Uterus PDXDC2P 0.31 0.20 enet 28 0.24 1.3e-05 -2.5 -5.5 3.0e-08 -0.03 0.05 0.19 TRUE
16 METSIM Adipose DHX38 0.08 0.06 lasso 7 0.09 4.5e-13 -5.5 5.9 4.3e-09 0.53 0.96 0.04 FALSE
17 NTR Blood DHX38 0.02 0.01 blup 355 0.02 6.5e-06 -4.4 5.2 1.7e-07 0.34 0.84 0.12 FALSE
18 The Cancer Genome Atlas Glioblastoma Multiforme HPR 0.82 0.49 lasso 3 0.47 3.4e-16 6.9 7.0 3.5e-12 0.69 0.00 1.00 FALSE
19 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma HP 0.02 0.01 blup 53 0.02 5.9e-03 3.8 -5.2 1.6e-07 -0.35 0.10 0.21 FALSE
20 The Cancer Genome Atlas Brain Lower Grade Glioma DHX38 0.02 0.01 blup 62 0.01 1.7e-02 -4.4 5.4 7.1e-08 0.25 0.04 0.41 FALSE
21 The Cancer Genome Atlas Brain Lower Grade Glioma HP 0.60 0.42 lasso 5 0.41 3.8e-50 6.9 7.0 3.3e-12 0.70 0.00 1.00 FALSE
22 The Cancer Genome Atlas Brain Lower Grade Glioma HPR 0.75 0.56 lasso 4 0.56 6.1e-76 6.9 6.9 5.6e-12 0.70 0.00 1.00 FALSE
23 The Cancer Genome Atlas Brain Lower Grade Glioma TXNL4B 0.44 0.29 lasso 4 0.29 3.2e-33 6.9 7.0 2.2e-12 0.70 0.00 1.00 TRUE
24 The Cancer Genome Atlas Prostate Adenocarcinoma HP 0.05 0.04 blup 53 0.04 9.8e-05 5.0 -5.8 7.9e-09 -0.49 0.42 0.54 FALSE
25 The Cancer Genome Atlas Rectum Adenocarcinoma COG4 0.33 0.09 enet 12 0.15 2.5e-04 4.3 5.5 3.8e-08 -0.03 0.01 0.76 FALSE
26 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma AARS 0.10 0.09 lasso 2 0.06 7.6e-03 4.8 5.2 2.0e-07 0.00 0.00 0.34 FALSE