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chr16:68,467,643-72,845,749

Best TWAS P=2.18e-12 · Best GWAS P=2.12e-12 conditioned to 0.0011

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	TXNL4B	0.44	0.29	lasso	4	0.29	3.2e-33	6.9	7.0	2.2e-12	0.70	0.00	1.00	TRUE
15	GTEx	Uterus	PDXDC2P	0.31	0.20	enet	28	0.24	1.3e-05	-2.5	-5.5	3.0e-08	-0.03	0.05	0.19	TRUE
13	GTEx	Skin Not Sun Exposed Suprapubic	SF3B3	0.11	0.14	enet	6	0.12	2.5e-07	-5.3	5.4	6.1e-08	-0.06	0.00	1.00	TRUE
7	GTEx	Brain Cortex	CIRH1A	0.49	0.29	enet	22	0.30	4.7e-09	-3.6	5.2	2.5e-07	-0.01	0.09	0.50	TRUE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	HP	0.60	0.42	lasso	5	0.41	3.8e-50	6.9	7.0	3.3e-12	0.70	0.00	1.00	FALSE
18	The Cancer Genome Atlas	Glioblastoma Multiforme	HPR	0.82	0.49	lasso	3	0.47	3.4e-16	6.9	7.0	3.5e-12	0.69	0.00	1.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	HPR	0.72	0.60	lasso	7	0.61	6.9e-94	6.9	6.9	4.2e-12	0.74	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	HPR	0.75	0.56	lasso	4	0.56	6.1e-76	6.9	6.9	5.6e-12	0.70	0.00	1.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	TXNL4B	0.05	0.07	lasso	3	0.06	8.8e-08	6.9	6.4	1.7e-10	0.78	0.00	1.00	FALSE
6	GTEx	Brain Cortex	DHODH	0.21	0.06	enet	14	0.05	1.5e-02	5.0	6.1	1.2e-09	0.65	0.03	0.74	FALSE
9	GTEx	Esophagus Muscularis	DHX38	0.09	0.07	lasso	7	0.05	4.2e-04	5.5	6.0	1.4e-09	0.64	0.31	0.53	FALSE
12	GTEx	Ovary	IST1	0.31	0.03	enet	37	0.07	1.0e-02	-2.7	-6.0	2.7e-09	-0.35	0.08	0.08	FALSE
16	METSIM	Adipose	DHX38	0.08	0.06	lasso	7	0.09	4.5e-13	-5.5	5.9	4.3e-09	0.53	0.96	0.04	FALSE
24	The Cancer Genome Atlas	Prostate Adenocarcinoma	HP	0.05	0.04	blup	53	0.04	9.8e-05	5.0	-5.8	7.9e-09	-0.49	0.42	0.54	FALSE
25	The Cancer Genome Atlas	Rectum Adenocarcinoma	COG4	0.33	0.09	enet	12	0.15	2.5e-04	4.3	5.5	3.8e-08	-0.03	0.01	0.76	FALSE
8	GTEx	Colon Sigmoid	PDXDC2P	0.30	0.16	enet	13	0.14	8.8e-06	4.5	-5.4	5.5e-08	0.00	0.03	0.94	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DHX38	0.31	0.39	enet	41	0.41	3.2e-54	5.0	5.4	6.2e-08	0.48	1.00	0.00	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	DHX38	0.02	0.01	blup	62	0.01	1.7e-02	-4.4	5.4	7.1e-08	0.25	0.04	0.41	FALSE
10	GTEx	Liver	PDXDC2P	0.20	0.18	enet	8	0.13	1.5e-04	-4.9	-5.3	1.4e-07	0.04	0.01	0.95	FALSE
5	GTEx	Brain Cerebellum	PDPR	0.23	0.06	enet	20	0.11	3.7e-04	-4.0	-5.2	1.6e-07	0.04	0.05	0.28	FALSE
19	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HP	0.02	0.01	blup	53	0.02	5.9e-03	3.8	-5.2	1.6e-07	-0.35	0.10	0.21	FALSE
17	NTR	Blood	DHX38	0.02	0.01	blup	355	0.02	6.5e-06	-4.4	5.2	1.7e-07	0.34	0.84	0.12	FALSE
4	GTEx	Adrenal Gland	PDXDC2P	0.26	0.17	lasso	4	0.13	2.2e-05	4.8	-5.2	1.8e-07	-0.01	0.01	0.93	FALSE
26	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	AARS	0.10	0.09	lasso	2	0.06	7.6e-03	4.8	5.2	2.0e-07	0.00	0.00	0.34	FALSE
14	GTEx	Thyroid	PDXDC2P	0.41	0.27	lasso	10	0.30	5.0e-23	4.8	-5.2	2.7e-07	0.00	0.01	0.98	FALSE
11	GTEx	Ovary	COG4	0.15	0.20	lasso	2	0.15	1.4e-04	5.1	-5.1	2.8e-07	-0.03	0.01	0.78	FALSE