TWAS hub - CIRH1A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.130	0.0500	7.3e-04	0.071	NA	0.090	NA	0.105	1.8e-06	NA	7.8e-08	NA	6.7e-09
2	GTEx	Artery Tibial	0.135	0.0427	4.3e-05	0.080	NA	0.081	NA	0.078	7.4e-07	NA	6.1e-07	NA	9.9e-07
3	GTEx	Brain Cerebellar Hemisphere	0.704	0.1100	1.5e-04	0.202	NA	0.170	NA	0.275	6.7e-06	NA	3.8e-05	NA	9.5e-08
4	GTEx	Brain Cerebellum	0.218	0.0890	5.6e-03	0.235	NA	0.154	NA	0.186	1.5e-07	NA	2.7e-05	NA	3.6e-06
5	GTEx	Brain Cortex	0.487	0.0970	2.2e-06	0.294	NA	0.302	NA	0.297	8.3e-09	NA	4.7e-09	NA	6.7e-09
6	GTEx	Cells EBV-transformed lymphocytes	0.469	0.0870	1.3e-06	0.307	NA	0.169	NA	0.283	1.1e-10	NA	3.6e-06	NA	8.0e-10
7	GTEx	Cells Transformed fibroblasts	0.200	0.0580	1.8e-05	0.149	NA	0.153	NA	0.147	2.9e-11	NA	1.4e-11	NA	3.9e-11
8	GTEx	Muscle Skeletal	0.104	0.0362	5.9e-04	0.079	NA	0.073	NA	0.073	3.5e-08	NA	1.0e-07	NA	1.1e-07
9	GTEx	Nerve Tibial	0.210	0.0657	8.9e-05	0.087	NA	0.078	NA	0.069	9.7e-07	NA	3.3e-06	NA	1.2e-05
10	GTEx	Skin Sun Exposed Lower leg	0.247	0.0610	5.8e-07	0.109	NA	0.105	NA	0.101	2.5e-09	NA	5.2e-09	NA	1.1e-08
11	GTEx	Testis	0.331	0.0800	2.4e-06	0.112	NA	0.187	NA	0.178	1.2e-05	NA	1.0e-08	NA	2.5e-08
12	GTEx	Thyroid	0.166	0.0570	8.7e-05	0.105	NA	0.069	NA	0.090	1.9e-08	NA	5.4e-06	NA	2.0e-07
13	YFS	Blood	0.316	0.0429	0.0e+00	0.094	0.144	0.145	0.113	0.134	3.2e-29	8.7e-45	5.4e-45	6.3e-35	1.8e-41

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Qualifications: CSEs or equivalent	7.3	9.7	13.0	-3.3	-2.8	-2.9	-3.3	-2.6	-3.1	-3.5	-3.4	-3.6	-3.4	-3.6	-3.1	-0.7
Medication: Cholesterol lowering	6.4	10.0	14.0	3.4	2.9	2.7	3.1	3.6	2.8	3.1	3.1	2.7	3.3	3.2	3.3	3.7
Medication: Ramipril	5.8	7.4	11.6	3.1	2.5	2.2	2.5	2.9	2.1	3.4	2.8	2.4	2.0	3.1	2.7	3.1
Guilty feelings	5.7	8.6	12.4	-3.2	-2.5	-2.9	-3.2	-2.6	-3.2	-3.5	-3.1	-3.0	-3.3	-2.7	-3.2	-0.7
Cardiovascular Disease	5.6	18.6	26.6	4.8	3.5	4.8	4.2	5.2	3.6	4.4	4.2	4.3	3.9	4.4	4.3	4.1
Medication for cholesterol, blood pressure or diabetes	5.5	9.1	13.6	-3.2	-2.5	-3.3	-3.0	-3.7	-2.7	-2.7	-2.8	-2.5	-3.5	-2.7	-3.2	-2.9
BMI	4.7	27.3	41.0	5.5	5.0	4.7	5.0	4.6	4.4	4.7	5.2	5.6	5.8	5.6	5.0	6.4
Frequency of tenseness / restlessness in last 2 weeks	4.4	6.9	14.1	-2.7	-1.9	-3.2	-2.8	-2.7	-2.8	-2.9	-2.6	-1.6	-3.8	-2.0	-2.9	-0.9
Heart disease (siblings)	4.3	5.3	7.1	2.6	2.2	2.2	2.3	2.7	2.1	1.9	2.2	2.5	1.9	2.4	2.4	2.2
Medication: Blood pressure	4.2	7.4	12.2	3.0	1.9	3.2	2.9	3.5	2.6	2.5	2.5	2.2	3.0	2.6	3.0	2.1
Long-standing illness, disability or infirmity	4.1	6.3	11.3	2.4	2.1	2.6	2.6	3.4	2.5	2.5	2.3	2.7	2.0	2.6	2.7	1.9
Ovarian Cancer	3.8	5.1	7.1	2.5	2.2	2.4	2.4	1.4	2.2	2.6	2.4	2.1	2.7	2.0	2.2	1.8
Wears glasses or contact lenses	3.8	4.4	6.8	2.6	1.9	2.2	2.0	1.8	1.7	2.1	2.4	2.3	1.9	2.2	2.1	2.1
Number of self-reported non-cancer illnesses	3.7	6.4	13.3	2.4	2.6	2.4	2.5	3.6	2.3	2.5	2.4	2.5	2.2	2.4	2.7	2.1
Vascular/heart problems diagnosed by doctor	3.7	10.1	19.8	-3.7	-2.0	-3.3	-3.1	-4.4	-2.7	-3.2	-2.8	-2.5	-2.9	-2.9	-3.3	-3.8
Arm fat percentage (right)	3.5	13.8	28.5	4.1	3.1	3.3	3.4	3.8	2.8	3.3	3.5	3.2	4.1	4.1	3.6	5.3
Arm fat percentage (left)	3.3	13.2	29.5	4.0	3.1	3.2	3.2	3.7	2.7	3.1	3.4	3.2	3.9	4.0	3.4	5.4
Back pain experienced in last month	3.3	4.8	8.8	-2.6	-2.1	-3.0	-2.1	-2.0	-1.9	-2.1	-2.6	-1.6	-2.3	-2.5	-2.2	-0.7
High cholesterol (Self-reported)	3.3	5.8	12.8	2.1	2.9	3.6	1.8	2.4	1.5	2.8	2.5	2.3	2.0	2.7	2.1	1.7
Medication: Aspirin	3.2	4.3	8.7	2.3	2.2	1.7	1.7	2.6	1.4	2.1	2.2	1.5	2.2	1.7	1.8	2.9
Hair/balding pattern: Pattern 2	3.1	4.0	6.5	-2.0	-1.9	-1.8	-1.8	-2.2	-1.8	-2.0	-2.0	-2.2	-1.6	-1.9	-2.1	-2.6
Hayfever/allergic rhinitis (self-reported)	3.1	4.1	7.3	1.5	2.0	2.0	2.4	1.5	2.6	2.6	1.9	2.7	1.5	1.4	2.4	-0.8
Medication: Aspirin	3.1	4.0	9.2	2.0	2.1	1.4	1.6	2.6	1.4	2.1	2.0	1.4	2.1	1.7	1.7	3.0
Medication: Simvastatin	3.0	4.3	7.8	2.0	2.3	2.3	1.5	2.8	1.2	2.5	2.1	1.6	2.3	2.2	1.8	1.9
Medication: Bendroflumethiazide	3.0	4.6	8.5	2.6	1.4	2.9	1.8	2.7	1.3	2.0	2.0	1.4	1.8	2.5	2.2	2.4
Blood Eosinophil Count	2.9	22.1	59.4	3.6	7.4	2.7	2.7	4.4	2.2	3.0	5.1	3.3	4.6	6.3	3.7	7.7
Ever highly irritable/argumentative for 2 days	2.9	3.5	6.9	-1.7	-1.4	-2.5	-2.5	-1.6	-2.6	-1.9	-1.7	-2.0	-1.2	-1.4	-2.2	0.6
Arm fat mass (left)	2.9	11.8	26.7	3.9	2.5	2.6	3.3	3.8	2.7	3.3	3.0	3.2	3.7	3.2	3.4	5.2
Depression (self-reported)	2.8	3.4	6.5	-2.4	-0.6	-2.0	-2.3	-1.3	-2.2	-2.5	-1.8	-1.7	-1.8	-1.3	-2.2	-0.2
Arm fat mass (right)	2.8	11.5	25.0	3.7	2.6	2.5	3.2	3.7	2.8	3.3	3.0	3.2	3.7	3.2	3.4	5.0
Supplements: Vitamin C	2.8	3.3	6.3	-2.0	-2.0	-2.5	-1.5	-2.5	-1.2	-1.3	-1.9	-1.6	-1.6	-2.1	-1.5	-1.4
Vitamin and mineral supplements	2.7	3.7	7.4	2.0	1.5	2.5	2.0	2.7	1.8	2.0	1.7	1.8	1.6	1.6	2.1	0.5
High blood pressure	2.7	7.7	15.9	3.2	1.4	3.0	2.9	4.0	2.5	2.9	2.4	2.3	2.5	2.4	3.0	2.8
Pain experienced in last month	2.7	4.6	10.0	2.3	2.4	2.7	1.9	1.1	1.8	1.7	2.7	1.6	3.2	2.4	1.9	0.6
Eye problems/disorders: Diabetes related eye disease	2.6	2.8	5.1	2.0	1.0	1.5	1.6	1.8	1.3	1.8	1.7	1.2	2.0	2.3	1.8	1.7
Body mass index (BMI)	2.6	11.0	30.7	3.4	3.0	2.7	2.7	2.9	2.2	2.8	3.1	3.4	3.6	3.7	2.9	5.5
Number of children fathered	2.6	3.0	8.9	-1.8	-1.9	-1.6	-1.5	-0.6	-1.3	-1.2	-2.2	-1.7	-1.6	-3.0	-1.5	-1.3
Migraine (self-reported)	2.6	3.2	5.2	-1.4	-2.1	-1.4	-1.9	-2.1	-2.2	-1.8	-1.7	-1.6	-2.3	-1.3	-2.1	0.1
Hypertension (Self-reported)	2.6	7.3	15.8	3.2	1.3	2.9	2.8	4.0	2.4	2.8	2.3	2.3	2.5	2.3	3.0	2.5
Schizophrenia (2014)	2.5	5.4	9.3	-3.0	-0.7	-2.2	-3.1	-2.9	-3.0	-2.5	-2.3	-1.5	-2.1	-1.5	-2.8	-0.7
Type 2 Diabetes (T2D) (2012)	2.5	2.9	4.8	1.2	0.9	1.7	2.1	2.0	2.2	2.0	1.3	2.0	1.8	1.2	2.1	0.4
Lung cancer (father)	2.5	2.9	4.6	-1.8	-1.7	-1.1	-1.8	-2.1	-1.8	-1.6	-1.7	-1.8	-1.1	-1.6	-2.0	-1.9
Intelligence (Savage-Jansen 2018)	2.4	7.4	13.8	2.7	1.8	3.3	3.1	3.5	3.2	2.4	2.6	2.0	3.7	2.0	2.8	0.1
Pain all over the body in last month	2.4	2.5	4.5	-1.6	-1.8	-2.1	-1.6	-0.8	-1.5	-1.1	-1.9	-1.6	-1.8	-1.8	-1.5	-0.8
Neuroticism score	2.4	5.1	9.6	-2.0	-2.5	-2.9	-2.0	-0.4	-2.0	-1.8	-2.5	-1.8	-3.1	-2.9	-2.1	-1.9
Alcohol intake versus 10 years previously	2.4	3.7	5.9	2.1	1.9	2.2	1.7	1.6	1.5	1.5	2.2	2.4	1.1	2.4	1.6	2.1
Basal cell carcinoma (self-reported)	2.4	2.9	4.7	1.6	1.5	2.2	1.9	1.4	2.0	1.7	1.8	2.1	1.2	1.5	1.5	-1.1
Schizophrenia vs Biploar Disorder	2.3	3.1	4.3	-1.6	-1.9	-2.0	-1.9	-1.0	-1.9	-1.4	-1.8	-2.0	-1.6	-2.0	-2.1	-1.5
Average weekly fortified wine intake	2.3	2.7	4.6	1.4	1.4	1.6	1.9	1.7	1.9	1.8	1.6	1.2	1.9	1.7	2.1	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.5	8.0	-1.9	-1.2	-2.4	-2.1	-1.0	-2.1	-1.8	-1.9	-1.3	-2.8	-1.9	-2.1	-0.9
Health satisfaction	2.3	3.0	8.1	-1.8	-0.7	-1.7	-1.9	-2.6	-1.8	-1.9	-1.4	-0.6	-2.8	-0.7	-1.9	0.3
HbA1C	2.2	2.4	6.0	1.8	0.9	2.5	1.7	0.8	1.6	1.5	1.7	1.2	2.1	1.5	1.4	-0.3
HDL Cholesterol	2.2	3.7	6.2	-1.5	-2.2	-1.6	-2.2	-1.1	-2.2	-2.3	-1.7	-2.5	-1.7	-2.0	-1.9	-1.6
Townsend deprivation index at recruitment	2.2	3.2	18.5	1.4	2.7	1.1	0.6	0.5	0.1	0.3	1.8	1.3	0.9	2.3	0.4	4.3
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.6	7.5	-2.1	-0.5	-2.7	-2.3	-0.9	-2.2	-2.5	-1.8	-1.3	-2.5	-1.1	-2.2	0.6
Falls in the last year	2.2	3.0	6.6	1.9	1.4	1.2	1.7	2.6	1.6	1.5	1.7	1.4	1.6	1.8	1.7	2.0
Handedness (chirality/laterality): Left-handed	2.2	2.6	6.5	-1.4	-2.5	-1.3	-1.4	-0.6	-1.2	-0.3	-1.8	-1.8	-1.2	-2.0	-1.2	-2.6
Friendships satisfaction	2.2	2.7	5.0	-1.5	-1.8	-2.2	-1.8	-1.4	-1.8	-1.4	-1.5	-1.1	-2.2	-1.6	-1.9	-0.6
Mineral and other dietary supplements	2.2	2.9	5.9	2.2	0.5	2.2	1.8	2.4	1.6	1.8	1.3	1.8	1.4	1.1	1.9	0.9
Average weekly spirits intake	2.1	2.6	5.1	1.7	1.8	0.8	1.3	0.9	1.1	1.1	1.8	1.5	2.3	2.1	1.5	2.2
Exposure to tobacco smoke at home	2.1	2.4	4.0	-1.2	-1.1	-1.8	-1.8	-1.7	-1.9	-2.0	-1.5	-1.0	-1.7	-1.4	-1.9	0.0
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.4	10.1	-1.5	-2.6	-2.8	-1.5	-1.4	-1.6	-1.4	-2.5	-1.9	-2.4	-3.2	-1.8	-1.6
Ever unenthusiastic/disinterested for a whole week	2.0	2.4	4.9	-1.4	-2.2	-1.9	-1.7	-1.3	-1.8	-1.4	-1.9	-1.3	-0.7	-1.5	-1.7	0.2
Illnesses of siblings	2.0	2.8	5.8	-1.8	-1.4	-2.4	-1.6	-2.0	-1.4	-1.4	-1.7	-1.7	-1.3	-1.7	-1.6	-1.3
Body fat percentage	2.0	7.8	21.3	3.1	2.2	2.2	2.4	3.4	1.9	2.7	2.4	2.4	2.7	2.8	2.6	4.6
Leg fat percentage (right)	2.0	7.2	28.2	2.8	2.4	2.0	1.9	2.4	1.3	2.2	2.4	2.6	2.2	3.1	2.0	5.3
Trunk fat percentage	1.9	7.6	16.2	3.1	2.1	2.3	2.5	3.7	2.1	2.9	2.2	2.2	2.9	2.5	2.7	4.0
Leg fat mass (right)	1.9	7.4	21.3	2.9	2.1	1.7	2.4	3.1	1.9	2.7	2.2	2.8	2.7	2.4	2.6	4.6
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	9.5	-1.2	-1.9	-1.0	-1.0	-1.5	-0.8	-1.0	-1.4	-1.0	-1.4	-1.7	-1.3	-3.1
Crohns Disease (2017)	1.8	3.9	6.4	2.0	1.4	1.9	2.2	2.5	2.1	1.6	1.9	1.7	1.8	2.3	2.4	1.5
LDL Cholesterol	1.8	2.8	4.5	1.5	1.3	2.0	2.0	1.3	2.1	1.4	1.7	2.1	1.9	1.4	1.9	-0.1
Peak expiratory flow (PEF)	1.8	4.1	11.2	-1.9	-2.6	-2.2	-1.1	-0.7	-0.6	-0.5	-2.2	-2.1	-2.3	-3.4	-1.3	-2.9
Medication: Blood pressure	1.8	3.5	10.9	2.3	1.0	2.7	1.5	3.3	1.1	1.8	1.7	1.0	1.2	1.7	2.0	1.3
Medication: Atorvastatin	1.8	2.2	3.9	1.6	0.8	0.8	1.9	0.9	1.8	1.6	1.5	2.0	1.6	1.5	1.9	0.8
Schizophrenia (2018)	1.7	3.5	7.6	-2.3	-0.2	-1.9	-2.5	-2.8	-2.5	-1.7	-1.7	-1.0	-1.9	-0.7	-2.3	0.0
Verbal and Numeric Reasoning (VNR)	1.7	4.0	13.2	1.8	1.0	2.1	2.3	3.6	2.3	1.5	1.7	0.9	2.7	1.2	2.1	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.8	7.0	1.4	1.9	2.1	2.3	0.8	2.5	2.2	1.9	2.6	1.9	2.0	2.1	0.3
Supplements: Glucosamine	1.7	2.2	5.0	-2.2	0.3	-1.9	-1.6	-2.2	-1.3	-1.5	-1.2	-0.9	-1.6	-0.8	-1.6	-0.7
Number of incorrect matches in round	1.7	2.9	6.3	-2.0	-1.5	-0.9	-1.8	-2.5	-1.7	-1.7	-1.6	-1.6	-1.5	-1.2	-1.7	-1.8
Nervous feelings	1.7	3.2	8.8	-1.5	-2.8	-1.5	-1.1	-0.4	-0.7	-0.5	-1.9	-1.2	-2.5	-2.5	-0.9	-3.0
Allergy	1.7	3.8	5.9	-1.7	-2.3	-2.1	-1.7	-1.7	-1.7	-1.6	-2.0	-2.0	-1.6	-2.4	-2.1	-2.3
Whole body fat mass	1.7	7.3	18.1	3.1	1.8	1.8	2.6	3.5	2.1	2.8	2.1	2.4	2.8	2.2	2.7	4.3
Medication: Paracetamol	1.7	2.7	5.4	-1.6	-1.2	-2.3	-1.9	-0.8	-1.9	-1.4	-1.7	-1.2	-2.2	-1.8	-1.9	0.0
Irritability	1.7	2.9	7.3	-1.7	-0.7	-2.7	-2.2	-1.3	-2.1	-1.5	-1.6	-1.1	-2.4	-1.2	-2.0	0.1
Neuroticism (Nagel 2018)	1.6	3.7	7.4	-1.7	-1.9	-2.6	-1.8	-0.6	-1.7	-1.5	-2.1	-1.4	-2.7	-2.5	-1.9	-1.6
Body Mass Index (BMI) (2010)	1.6	2.2	4.8	1.6	1.0	1.0	1.7	1.6	1.7	1.4	1.4	2.2	1.3	1.4	1.5	0.8
Blood Red Count	1.6	15.4	25.5	4.5	1.3	4.0	4.8	3.1	4.8	4.6	4.0	3.8	5.0	3.2	4.4	-0.9
Blood White Count	1.6	12.0	19.0	3.2	4.3	3.5	3.1	3.2	2.8	3.4	3.8	3.2	3.1	4.4	3.3	3.5
Hayfever, allergic rhinitis or eczema	1.6	3.4	5.3	1.4	2.3	2.0	1.7	1.7	1.8	1.6	1.9	2.3	0.9	2.1	2.1	1.8
Trunk fat mass	1.6	7.0	14.3	3.0	1.6	1.8	2.6	3.6	2.2	2.9	2.0	2.2	2.9	1.9	2.8	3.8
Medication: Omeprazole	1.6	1.9	7.2	1.4	1.9	0.9	0.6	1.1	0.2	0.6	1.5	1.2	1.1	1.9	0.7	2.7
Age at last live birth	1.6	2.3	5.8	1.4	1.4	1.7	1.8	1.6	1.9	2.4	1.5	1.3	0.6	0.8	1.6	-0.2
Knee pain experienced in last month	1.6	2.6	5.1	-2.0	-1.2	-1.8	-1.9	-0.9	-2.0	-1.4	-1.8	-1.7	-2.2	-0.7	-1.5	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.8	5.2	1.6	1.2	1.2	1.3	2.3	1.0	1.4	1.3	0.6	1.6	1.0	1.2	1.0
Leg fat mass (left)	1.6	6.2	16.2	2.7	1.8	1.6	2.2	2.9	1.8	2.6	2.0	2.6	2.5	2.1	2.4	4.0
Bipolar Disorder or Schizophrenia	1.5	3.6	11.6	-2.3	0.4	-1.8	-2.5	-3.4	-2.4	-2.0	-1.4	-0.6	-1.6	-0.3	-2.3	0.0
Waist circumference	1.5	5.6	11.0	2.4	1.8	1.5	2.2	3.3	2.1	2.8	1.9	2.4	2.5	1.8	2.5	2.9
Had major operations	1.5	1.7	4.4	1.4	1.1	0.1	1.3	1.7	1.3	0.5	1.0	1.1	1.3	1.3	1.5	2.1
Medication: Lisinopril	1.5	1.9	6.0	1.3	1.2	0.8	0.9	0.6	0.7	0.8	1.3	0.8	2.4	1.9	1.2	2.5
Illnesses of father: High blood pressure	1.5	1.9	3.5	1.1	1.8	0.9	1.3	1.9	1.6	1.3	1.7	1.9	0.2	1.2	1.3	-0.1
Leg fat percentage (left)	1.5	5.5	19.5	2.5	2.0	1.9	1.7	2.1	1.1	2.1	2.1	2.4	2.1	2.7	1.8	4.4
Triglycerides	1.4	2.3	3.8	1.3	1.9	2.0	1.3	1.0	1.3	1.6	1.5	1.8	0.6	1.8	1.3	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.4	12.6	-1.8	-2.9	-2.0	-0.7	-0.7	-0.1	-0.4	-2.2	-1.5	-2.8	-3.5	-0.8	-3.5
High blood pressure (siblings)	1.4	1.9	4.9	1.3	1.4	2.2	1.2	1.4	1.1	1.1	1.5	1.6	1.2	1.7	1.2	0.2
Forced vital capacity (FVC), Best measure	1.4	5.1	15.3	-2.0	-3.0	-2.7	-0.9	-0.8	-0.4	-0.9	-2.4	-1.6	-2.6	-3.9	-1.1	-3.5
Loneliness, isolation	1.4	1.9	2.9	-1.6	-1.4	-1.6	-1.5	-0.5	-1.4	-1.0	-1.7	-1.3	-1.5	-1.7	-1.4	0.3
Systolic Blood Pressure	1.3	6.5	10.2	2.4	2.0	3.2	2.8	2.4	2.8	2.9	2.4	3.2	2.7	2.1	2.7	-0.4
Lung FVC	1.3	6.6	11.2	-2.9	-2.7	-2.4	-2.5	-1.5	-2.2	-2.2	-3.1	-2.5	-3.4	-3.1	-2.2	-2.2
Number of treatments/medications taken	1.3	2.3	7.5	1.3	2.1	1.1	0.7	2.6	0.3	1.0	1.3	0.9	0.7	1.6	1.1	2.7
Severe depression (siblings)	1.3	1.5	5.5	-1.1	0.1	-1.2	-1.2	-1.5	-1.2	-1.6	-0.5	0.2	-2.4	-0.6	-1.3	-0.8
Serious illness, injury or assault to yourself	1.3	1.6	6.1	0.9	1.3	0.6	0.8	1.2	0.7	0.7	1.0	0.7	2.5	1.8	1.0	1.7
Medication: Atenolol	1.3	1.6	4.3	1.5	0.8	1.0	0.9	1.7	0.5	0.8	1.1	0.3	2.1	1.4	1.1	1.9
Worrier / anxious feelings	1.3	2.5	6.3	-1.2	-2.0	-1.0	-1.1	-0.3	-1.0	-0.5	-1.7	-1.1	-2.5	-2.4	-1.4	-2.4
Leg pain on walking	1.3	1.7	2.8	-1.6	-0.3	-1.2	-1.6	-1.4	-1.6	-1.7	-1.2	-0.7	-1.4	-1.0	-1.6	0.1
Age started oral contraceptive pill	1.3	1.7	6.2	-0.6	-2.5	-0.2	-0.8	-0.4	-0.8	-0.0	-1.4	-1.5	-1.3	-1.7	-0.8	-2.1
Depressed Affect (Nagel 2018)	1.2	2.5	5.9	-1.4	-1.0	-2.4	-1.7	-0.5	-1.7	-1.7	-1.7	-1.0	-1.9	-2.0	-1.8	-0.9
Alzheimer’s Disease (in father)	1.2	1.3	4.5	-0.9	-1.0	-1.0	-0.9	-0.9	-0.7	-1.1	-0.9	-1.1	-1.5	-1.2	-0.9	-2.1
Crohns Disease (2012)	1.2	1.9	4.1	1.0	1.2	1.0	1.6	2.0	1.7	0.6	1.2	1.2	1.5	1.6	1.9	0.9
Allergy or Eczema	1.2	3.2	6.7	1.2	2.6	1.9	1.6	1.5	1.6	1.4	1.7	2.3	0.5	2.2	1.9	1.8
Chronic bronchitis/emphysema (father)	1.2	1.4	3.0	-0.9	1.1	-0.8	-1.5	-1.1	-1.7	-1.5	-0.2	-0.5	-1.3	0.8	-1.4	1.7
Wheeze or whistling in the chest in last year	1.2	2.1	6.8	1.4	1.1	1.3	1.0	2.4	0.7	1.2	1.0	0.3	1.6	1.0	1.4	2.6
Angina (self-reported)	1.2	1.5	3.5	1.6	0.1	-0.7	1.2	1.9	1.1	1.4	0.7	0.6	1.6	0.3	1.2	1.9
Medication: Ibuprofen	1.2	1.4	3.0	-1.3	0.7	-0.1	-1.6	-0.7	-1.7	-1.7	-0.7	-0.8	-1.7	-0.2	-1.6	0.7
Risk taking	1.2	1.8	3.6	-1.2	-0.8	-1.7	-1.5	-0.3	-1.5	-1.6	-1.4	-1.2	-1.9	-0.9	-1.1	1.5
Depression (Nagel 2018)	1.1	1.6	3.1	-1.3	-0.8	-1.4	-1.5	-0.9	-1.5	-1.3	-1.3	-0.7	-1.8	-1.3	-1.6	0.1
Reaction Time	1.1	2.1	6.3	-1.1	-2.5	-0.8	-1.3	-1.4	-1.2	-1.1	-1.8	-1.1	-1.7	-1.7	-1.2	-1.1
Fasting Glucose	1.1	1.3	2.9	-1.2	-0.9	-1.6	-1.1	-1.1	-1.0	-1.7	-1.2	-1.0	-0.8	-0.6	-1.0	0.9
Neuroticism (2016)	1.1	1.6	4.0	-0.3	-1.9	-1.5	-1.2	0.3	-1.6	-0.8	-1.4	-1.2	-2.0	-1.2	-1.0	-0.0
Neuroticism	1.1	2.7	5.9	-1.4	-1.8	-2.0	-1.3	-0.3	-1.1	-1.2	-1.8	-0.9	-2.4	-2.3	-1.5	-2.1
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	2.0	-1.4	-1.1	-1.0	-1.4	-1.2	-1.4	-1.0	-1.3	-1.1	-1.3	-1.0	-1.3	-0.2
Angina	1.1	1.5	3.6	1.5	0.1	-0.7	1.2	1.9	1.1	1.3	0.7	0.6	1.7	0.3	1.2	1.8
Medication: Metformin	1.1	1.5	4.5	1.2	1.0	0.8	1.1	2.1	1.0	0.7	1.0	1.4	1.6	0.9	1.3	1.3
Pack years adult smoking proportion	1.1	1.7	5.7	0.9	2.2	1.2	0.5	1.2	0.3	0.5	1.5	1.3	0.9	1.5	0.3	2.4
Forced vital capacity (FVC)	1.1	4.1	13.3	-1.7	-2.8	-2.6	-0.7	-0.4	-0.1	-0.7	-2.3	-1.5	-2.3	-3.6	-0.7	-2.9
Fluid intelligence score	1.1	2.2	8.4	1.2	0.6	2.0	1.6	2.9	1.6	0.8	1.1	0.4	2.0	0.7	1.4	-0.9
Weight	1.1	5.2	9.7	2.6	0.9	1.0	2.5	3.0	2.2	2.8	1.5	2.3	2.4	1.1	2.6	3.1
Hip circumference	1.1	4.9	12.2	2.2	2.0	1.1	2.0	2.3	1.8	2.3	1.9	2.5	2.3	2.1	2.2	3.5
Forced expiratory volume in 1-second (FEV1)	1.1	3.8	12.2	-1.6	-2.7	-2.1	-0.5	-0.4	0.0	-0.1	-2.1	-1.4	-2.5	-3.5	-0.6	-3.1
Worry too long after embarrassment	1.1	1.8	4.3	-1.4	-1.6	-2.1	-1.1	-0.8	-1.1	-0.8	-1.4	-1.0	-1.9	-1.5	-1.3	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	3.7	-1.6	0.3	-1.2	-1.4	-1.9	-1.3	-1.0	-0.9	0.0	-1.3	-0.6	-1.6	-1.0
Qualifications: College or University degree	1.1	3.4	6.8	0.8	2.6	1.5	2.0	1.8	2.4	1.9	1.8	2.4	1.8	1.3	1.7	-1.2
Commuting to job workplace: Public transport	1.1	1.4	3.0	1.1	-0.1	1.5	1.4	1.7	1.5	1.0	0.8	1.0	0.3	0.9	1.5	-1.1
Eye problems/disorders: Glaucoma	1.1	1.3	4.1	1.6	-0.2	0.5	1.2	1.5	0.9	0.9	0.9	0.2	0.5	1.2	1.5	2.0
Commuting to job workplace: Cycle	1.1	1.4	3.1	1.0	0.5	1.8	1.5	0.6	1.6	1.2	1.2	1.4	0.8	0.6	1.5	0.4
Prostate Cancer	1.0	1.4	4.7	0.6	1.4	0.1	1.2	2.2	1.4	1.2	0.9	1.2	0.7	0.9	1.5	0.3
Fed-up feelings	1.0	1.9	6.0	-0.9	-1.1	-2.4	-1.4	-0.1	-1.6	-1.1	-1.5	-0.7	-2.0	-1.4	-1.3	0.6
Multivitamins +/- minerals	1.0	1.3	2.4	-1.0	-0.7	-1.5	-1.2	-1.6	-1.1	-1.4	-0.9	-1.0	-1.2	-0.8	-1.3	0.4
Impedance of leg (left)	1.0	4.9	12.2	-2.2	-2.1	-1.6	-2.0	-1.4	-1.8	-1.5	-2.2	-2.1	-3.5	-2.6	-2.1	-2.9
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	4.6	0.7	1.5	2.1	1.7	0.5	2.1	1.5	1.2	2.0	1.7	1.3	1.6	-0.4
Mean time to correctly identify matches	1.0	1.9	6.6	-0.8	-2.6	-0.3	-1.1	-1.1	-1.2	-0.9	-1.7	-1.4	-1.2	-1.7	-1.1	-1.5
Mood swings	1.0	1.8	4.5	-0.7	-1.2	-2.1	-1.5	-0.3	-1.7	-1.0	-1.3	-1.0	-1.7	-1.7	-1.6	-0.5
Worry (Nagel 2018)	0.9	2.0	6.5	-1.1	-1.6	-1.2	-1.0	0.0	-0.8	-0.7	-1.5	-0.9	-1.9	-2.2	-1.1	-2.6
Lupus	0.9	1.3	3.7	-1.3	-1.1	-1.1	-0.9	-0.6	-0.6	-1.1	-1.3	-0.4	-1.4	-1.3	-1.1	-1.9
Ulcerative Colitis	0.9	1.3	4.3	-0.4	2.1	1.1	0.7	0.5	1.1	0.2	1.0	0.1	2.0	1.6	1.1	0.8
Chronotype (morning person)	0.9	2.0	5.0	-1.3	-2.2	-1.8	-0.9	-0.9	-0.7	-0.6	-1.7	-1.6	-2.0	-1.6	-0.8	-1.1
Hand grip strength (left)	0.9	2.3	8.5	-1.6	-1.0	-1.8	-0.6	-1.8	-0.1	-0.7	-1.2	0.1	-1.8	-2.3	-0.9	-2.9
Ever used hormone-replacement therapy (HRT)	0.9	1.1	3.2	-0.5	-1.5	-0.7	-0.8	-0.1	-0.9	-1.1	-1.2	-1.1	-1.8	-1.4	-0.7	-0.3
Ever had hysterectomy (womb removed)	0.9	1.0	2.0	0.8	1.4	0.5	0.9	1.0	0.8	0.3	1.1	1.2	1.1	1.1	0.9	1.2
Age when periods started (menarche)	0.9	2.2	6.1	-0.6	-2.4	-1.4	-0.7	-1.3	-0.8	-0.9	-1.2	-1.5	-2.5	-1.6	-0.9	-1.8
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.5	-0.8	-1.4	-0.8	-0.9	-0.9	-0.9	0.1	-1.0	-0.8	-1.6	-1.4	-1.0	-1.2
Pulse rate	0.9	1.5	2.7	1.5	1.2	0.8	1.3	1.5	1.1	1.3	1.3	0.7	1.7	1.0	1.2	0.9
Medication: Paracetamol	0.9	1.5	3.8	-1.0	-1.1	-1.9	-1.2	-0.1	-1.2	-0.9	-1.3	-0.8	-1.6	-1.7	-1.2	0.4
Headache pain in last month	0.9	1.6	4.6	-1.0	-1.4	-0.9	-1.1	-0.7	-1.3	-1.2	-1.6	-0.9	-2.1	-1.4	-1.2	-0.2
Medication: Amlodipine	0.9	1.3	5.6	1.0	0.8	1.9	0.8	2.4	0.7	1.2	0.9	0.6	0.5	0.8	1.0	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	1.9	-1.1	-0.2	-1.3	-1.1	-0.8	-1.1	-1.0	-1.0	-0.6	-1.4	-1.2	-1.2	0.7
Diastolic blood pressure, automated reading	0.9	2.7	5.5	1.8	-1.3	1.2	2.2	2.1	2.3	1.9	0.8	1.1	1.8	-0.1	2.4	0.1
Pack years of smoking	0.9	1.4	4.3	0.8	1.9	1.2	0.5	1.1	0.3	0.5	1.4	1.2	0.9	1.4	0.3	2.1
Systolic blood pressure, automated reading	0.8	2.3	5.4	1.0	1.1	1.8	1.6	0.7	1.8	1.5	1.3	2.3	1.8	1.5	1.7	-0.5
Medication for hormone replacement therapy	0.8	0.9	3.7	-0.7	-1.4	-1.0	-0.4	0.2	-0.3	-0.3	-1.2	-0.9	-1.2	-1.9	-0.4	-0.7
Hair/balding pattern: Pattern 3	0.8	1.2	3.3	1.0	-0.2	0.6	1.2	1.8	1.2	1.3	0.6	0.9	0.3	0.8	1.4	1.5
Qualifications: A levels/AS levels or equivalent	0.8	1.8	3.8	0.6	1.7	1.2	1.4	1.1	1.8	1.4	1.1	1.1	1.7	0.4	1.1	-2.0
Tense / ‘highly strung’	0.8	1.3	4.3	-1.1	-1.0	-1.2	-1.1	0.2	-1.0	-0.6	-1.4	-0.8	-2.1	-1.6	-0.9	-0.8
Eye problems/disorders: None of the above	0.8	0.9	3.2	-1.1	-0.8	-0.4	-0.6	-0.8	-0.5	-0.5	-1.0	-0.4	-1.2	-1.1	-0.8	-1.8
Ever had bowel cancer screening	0.8	1.0	3.9	-0.2	-2.0	-0.9	-0.2	0.2	-0.0	0.4	-0.9	-1.1	0.3	-1.6	-0.1	-1.7
Supplements: Fish oil (including cod liver oil)	0.8	1.0	3.1	-1.3	0.2	-1.8	-1.0	-1.5	-0.8	-0.8	-0.6	-0.9	-0.9	-0.5	-1.1	-0.5
Fractured/broken bones in last 5 years	0.8	1.1	2.1	1.3	0.7	0.5	1.0	1.0	0.7	0.9	1.1	0.9	1.0	1.4	1.1	1.3
Cholesterol lowering medication	0.8	1.2	3.9	0.7	1.4	2.0	0.5	0.9	0.4	1.6	1.1	0.6	1.2	1.2	0.8	0.3
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	4.7	1.2	1.2	0.6	0.3	0.9	-0.2	0.5	1.0	0.8	0.2	1.4	0.3	2.2
Mean Putamen Volume	0.7	0.8	4.1	0.1	2.0	0.7	0.5	0.2	0.8	0.9	0.7	1.5	-0.2	0.7	0.7	0.3
Hypothyroidism (self reported)	0.7	1.6	5.9	0.9	2.0	0.9	0.9	2.4	1.1	0.5	1.3	0.9	1.5	0.7	1.1	0.2
Sensitivity / hurt feelings	0.7	1.2	3.9	-0.4	-2.0	-1.2	-0.2	0.9	-0.0	0.0	-1.1	-0.3	-1.4	-1.6	-0.2	-1.9
Medication: Co-codamol	0.7	0.8	1.9	-1.1	-0.8	-1.3	-0.9	-0.1	-0.8	-1.4	-1.1	-0.7	-0.3	-1.0	-0.9	-0.3
Impedance of leg (right)	0.7	3.5	9.9	-2.0	-1.7	-1.6	-1.7	-0.9	-1.6	-1.3	-1.9	-1.9	-3.1	-2.1	-1.8	-1.8
Maternal smoking around birth	0.7	1.0	2.9	-0.8	-0.2	-0.5	-1.3	1.1	-1.4	-1.2	-0.8	-1.7	0.4	0.1	-0.9	1.2
Medication: Levothyroxine sodium	0.7	1.2	2.2	-1.3	-0.1	-1.2	-1.3	-0.5	-1.1	-1.3	-1.1	-0.8	-0.7	-1.1	-1.2	-1.5
Father’s age at death	0.7	0.9	4.9	-1.3	0.3	-1.0	-0.7	-1.4	-0.3	-0.4	-0.5	0.2	-0.7	-0.7	-0.7	-2.2
Mouth/teeth dental problems: Dentures	0.7	1.1	9.5	0.7	0.6	0.4	-0.1	1.1	-0.5	0.5	0.6	0.9	-0.3	1.0	0.2	3.1
Standing height	0.7	6.8	26.9	-1.3	-4.0	-3.2	-0.2	0.7	0.3	0.4	-3.0	-1.8	-1.8	-5.2	-0.3	-4.2
Hair/balding pattern: Pattern 4	0.7	1.6	2.6	-1.5	-0.7	-1.1	-1.6	-0.8	-1.6	-1.3	-1.3	-1.4	-0.2	-1.5	-1.5	-1.0
Birth weight	0.7	1.4	4.3	-0.9	-1.7	-0.6	-0.7	-0.7	-0.7	-0.7	-1.6	-1.5	-1.1	-2.1	-0.8	-1.3
Number of full brothers	0.7	0.8	3.0	-0.3	-0.3	-0.5	-0.9	-0.4	-1.2	-1.5	-0.4	-0.3	-1.7	-0.1	-0.7	1.4
Age at first live birth	0.7	1.2	9.6	-1.4	-0.3	0.1	-0.3	-0.4	0.3	-0.2	-0.7	-0.6	-1.1	-1.3	-0.3	-3.1
Alcohol intake frequency.	0.7	1.7	7.7	-0.1	1.8	0.4	-0.6	-1.8	-0.8	-0.8	0.9	1.4	0.3	1.9	-0.4	2.8
Illnesses of siblings: Diabetes	0.7	0.9	7.8	0.6	-0.3	1.5	-0.1	-0.2	-0.6	-0.3	-0.2	0.1	-0.8	0.6	-0.1	2.8
Smoking status: Current	0.7	1.1	3.5	-0.8	0.1	-1.6	-1.1	-0.6	-1.3	-1.5	-0.8	-0.6	-0.9	-0.2	-0.9	1.9
Irritable Bowel Disease (IBD)	0.6	1.4	3.6	0.2	1.6	1.1	0.6	1.0	0.6	0.1	1.0	0.1	1.8	1.9	1.0	1.9
Major Depression (MDD)	0.6	0.7	2.2	-0.8	-1.5	-1.0	-0.5	-0.1	-0.4	-0.4	-1.1	-0.8	-0.7	-0.9	-0.6	-1.2
Respiratory disease	0.6	1.3	6.6	1.2	0.8	1.0	0.7	0.2	0.4	0.5	0.9	0.2	1.4	1.5	0.8	2.6
Type 2 Diabetes (T2D) (2018)	0.6	1.2	3.9	0.9	1.1	1.3	0.7	1.4	0.6	0.5	0.9	0.8	2.0	1.1	0.8	1.2
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.0	-1.0	-0.7	-1.1	-0.9	-0.7	-0.9	-0.9	-1.0	-0.3	-1.4	-0.7	-0.9	1.1
Hearing difficulty/problems: Yes	0.6	0.9	2.0	0.5	1.3	1.4	0.8	0.6	0.9	0.6	1.1	1.0	1.3	0.9	0.6	-0.6
Leg fat-free mass (left)	0.6	3.2	6.5	1.9	0.5	0.3	2.1	2.5	2.1	2.2	0.9	1.7	2.3	0.2	2.2	1.7
Hand grip strength (right)	0.6	1.5	5.2	-1.2	-0.6	-1.6	-0.5	-1.5	-0.2	-0.7	-1.0	-0.1	-1.0	-2.2	-0.9	-2.3
Relative age voice broke	0.6	0.9	3.8	-0.8	-0.7	-1.4	-0.4	-1.3	-0.2	-0.5	-0.6	0.0	-2.0	-1.0	-0.5	-0.7
High blood pressure (mother)	0.6	0.9	2.1	0.8	0.5	1.4	0.9	1.2	1.1	1.2	0.7	0.6	0.8	0.3	0.9	-0.9
Leg predicted mass (left)	0.6	3.3	6.6	1.9	0.5	0.3	2.2	2.6	2.2	2.2	0.9	1.8	2.3	0.2	2.2	1.8
Diabetes (self-reported)	0.6	1.0	4.7	0.9	0.0	0.3	0.6	1.9	0.4	0.7	0.3	0.3	2.2	0.3	0.9	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.7	0.4	1.3	0.3	0.5	0.4	0.7	0.6	1.1	0.7	0.7	1.6	0.6	0.6
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	4.1	0.2	-2.0	-0.4	0.3	0.6	0.4	0.2	-0.7	-0.8	0.4	-1.3	0.3	-1.4
Exposure to tobacco smoke outside home	0.6	0.8	2.2	-0.7	-0.7	-1.5	-0.9	-0.3	-1.0	-1.1	-1.0	-0.4	-0.8	-1.0	-0.9	0.6
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.5	-1.1	-0.8	-0.5	-0.9	-0.3	-0.8	-0.8	-1.2	-1.1	-0.1	-0.9	-0.6	0.7
Medication for pain relief, constipation, heartburn	0.6	0.9	8.2	-0.8	-1.1	-0.3	0.1	-1.0	0.5	-0.4	-0.5	-0.4	0.3	-0.3	0.2	-2.9
Pulse rate, automated reading	0.6	1.8	3.6	1.4	1.7	1.4	1.1	1.7	0.9	0.8	1.3	1.1	1.9	1.4	1.1	1.3
Overall health rating	0.6	1.2	1.8	-1.0	-0.9	-1.3	-1.2	-0.3	-1.3	-1.2	-1.3	-0.5	-1.3	-1.0	-1.2	1.2
Family relationship satisfaction	0.6	0.7	3.7	0.8	0.7	-0.3	0.6	1.0	0.5	0.4	0.5	1.3	-0.1	0.7	0.5	1.9
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.4	-0.1	-1.5	-0.5	-0.4	-0.4	-0.7	-1.0	-0.9	-0.9	-1.5	-1.2	-0.5	-0.5
Alcohol drinker status: Never	0.6	0.7	5.2	0.2	0.9	-0.1	-0.3	-0.6	-0.6	-0.1	0.3	0.5	0.4	1.2	-0.2	2.3
Basal metabolic rate	0.6	3.1	5.7	1.9	0.4	0.2	2.2	2.3	2.1	2.4	0.9	2.0	2.0	0.1	2.2	1.8
Myopia	0.6	0.8	2.4	1.1	-0.7	1.2	1.1	1.1	1.1	1.5	0.3	0.2	-0.3	0.2	1.1	-0.5
Impedance of whole body	0.6	3.2	7.3	-1.6	-1.8	-1.2	-1.4	-0.2	-1.2	-1.3	-1.8	-2.3	-2.7	-2.2	-1.4	-2.7
Bipolar Disorder (2018)	0.5	0.7	4.5	-0.8	1.0	-0.6	-0.7	-2.1	-0.7	-0.9	-0.1	0.3	-0.4	0.4	-0.8	0.2
Ulcerative Colitis (UC)	0.5	1.0	3.5	-1.1	1.9	0.5	-0.5	-0.4	-0.3	-0.8	0.4	-0.5	1.4	1.3	-0.2	1.6
Smoking Status	0.5	1.3	9.8	-0.1	-0.3	-1.5	-0.9	0.2	-1.3	-0.4	-0.7	-0.9	-0.1	0.1	-0.3	3.1
Stomach or abdominal pain in last month	0.5	0.6	2.4	0.0	-1.3	-0.8	-0.4	-0.4	-0.6	-0.4	-0.9	-0.3	-1.5	-1.0	-0.5	0.6
Sitting height	0.5	3.6	13.5	0.0	-3.2	-1.7	1.0	1.0	1.3	1.0	-1.9	-0.7	-1.1	-3.7	1.0	-3.1
Had other major operations	0.5	0.6	1.8	0.3	0.7	0.2	0.8	1.2	0.9	1.3	0.4	0.8	-0.0	0.3	1.0	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.6	-0.7	1.1	0.4	-0.9	-0.3	-1.0	-1.2	-0.2	-0.2	-1.3	0.1	-0.9	1.0
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	6.8	-0.8	0.7	0.3	0.2	0.4	0.6	-0.1	-0.2	-0.1	0.6	-0.8	-0.1	-2.6
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.5	0.8	1.2	1.1	0.2	0.6	0.1	0.7	0.9	0.4	0.9	0.9	0.4	1.2
Pulse wave peak to peak time	0.5	0.6	1.1	-1.0	-0.9	-1.0	-0.7	-0.1	-0.6	-0.7	-1.0	-0.6	-0.9	-0.7	-0.8	-0.8
Emphysema/chronic bronchitis	0.5	0.6	4.0	0.0	0.8	-0.1	-0.6	-0.8	-0.8	-0.8	0.3	0.5	-0.1	0.8	-0.4	2.0
Suffer from ‘nerves’	0.5	0.8	2.7	-0.5	-1.5	-0.8	-0.2	0.2	-0.2	-0.6	-1.1	-0.1	-1.2	-1.6	-0.3	-1.0
Illnesses of father: Heart disease	0.5	0.7	1.3	-0.9	-0.5	-1.2	-0.9	-0.8	-0.8	-1.1	-1.0	-0.3	-0.6	-0.9	-1.0	0.5
Smoking status: Previous	0.5	0.7	3.0	0.5	-0.7	0.3	0.4	1.3	0.5	1.0	-0.1	-1.1	1.7	-0.5	0.8	0.0
Leg fat-free mass (right)	0.5	2.5	4.8	1.7	0.2	0.1	2.0	2.2	2.0	2.1	0.7	1.5	2.1	-0.1	2.0	1.0
Medication for cholesterol	0.5	0.8	5.0	-0.9	-0.2	-1.1	-0.4	-2.2	-0.1	-1.3	-0.3	-0.1	-0.2	-0.0	-0.8	-0.8
Leg predicted mass (right)	0.5	2.4	4.8	1.7	0.2	0.1	1.9	2.2	2.0	2.0	0.7	1.5	2.1	-0.1	2.0	1.0
Hearing aid user	0.5	0.6	1.3	-0.4	0.2	-0.9	-0.8	-1.1	-1.0	-0.9	-0.2	-0.2	-0.8	0.6	-0.9	-0.7
Mother’s age at death	0.5	0.6	4.9	-0.5	-0.8	-0.3	0.2	0.4	0.5	0.6	-0.6	-0.2	0.2	-1.0	0.3	-2.2
Ever smoked	0.5	0.8	3.7	-0.3	-1.5	-0.2	-0.6	-0.0	-0.6	-0.1	-1.0	-1.9	-0.1	-1.5	-0.3	-0.8
Alcohol drinker status: Previous	0.5	0.5	2.4	0.0	1.5	1.1	0.3	0.1	0.5	-0.1	0.7	0.9	0.6	0.9	0.4	0.7
Breast Cancer	0.4	1.0	2.4	-0.6	-1.5	-0.4	-0.6	-1.2	-0.5	-0.9	-0.9	-0.3	-1.1	-1.4	-0.8	-1.5
Primary Biliary Cirrhosis	0.4	0.5	1.2	-0.8	0.5	-0.0	-0.8	-0.6	-0.8	-1.1	-0.5	-0.6	-1.1	0.0	-0.6	0.9
Current tobacco smoking	0.4	0.7	5.1	-0.4	0.5	-1.1	-0.6	-0.1	-0.8	-1.0	-0.3	-0.2	-0.5	0.3	-0.3	2.3
Past tobacco smoking	0.4	0.7	3.1	0.1	1.0	0.3	0.4	-0.7	0.4	-0.1	0.8	1.8	-1.1	1.3	0.0	0.4
Alcohol usually taken with meals	0.4	0.6	2.0	0.2	-0.1	0.3	0.9	0.4	1.3	1.4	0.1	1.0	0.4	0.2	1.1	-0.9
Hearing difficulty/problems with background noise	0.4	0.6	2.3	0.6	0.1	1.1	0.7	1.1	0.9	0.9	0.4	0.5	0.5	-0.4	0.5	-1.5
Mouth/teeth dental problems	0.4	0.7	2.6	0.2	1.6	0.9	0.7	-0.2	0.8	0.1	0.9	0.8	0.9	1.0	0.6	-0.5
Heart attack	0.4	0.5	3.5	0.4	-0.6	-0.5	0.1	1.2	-0.0	-0.3	-0.1	-0.3	0.2	0.5	0.3	1.9
Asthma	0.4	0.9	4.2	1.1	0.4	1.4	0.5	0.5	0.2	0.5	0.6	-0.2	1.2	0.8	0.6	2.0
Medication: Lansoprazole	0.4	0.4	3.0	0.7	-0.5	-0.4	0.5	1.7	0.3	0.3	0.1	-0.1	0.3	0.0	0.7	0.9
Prospective memory result	0.4	0.5	1.5	-0.7	-1.0	-1.2	-0.4	-0.1	-0.2	-0.0	-0.7	-0.9	-0.2	-0.8	-0.3	-1.2
Length of working week for main job	0.4	0.5	1.9	-0.8	0.8	0.1	-0.7	-1.4	-0.8	-0.0	0.0	-0.4	-0.5	0.2	-0.9	0.7
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.1	-0.2	-0.3	0.2	-0.9	-0.7	-1.1	-0.9	-0.3	-0.7	-0.5	-0.1	-1.0	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	3.6	0.3	-0.2	1.1	0.4	-0.0	0.5	0.9	0.2	0.3	0.1	-0.6	0.3	-1.9
Neck or shoulder pain in last month	0.4	0.5	2.0	-0.4	-0.1	-1.1	-0.6	0.3	-0.8	-0.2	-0.6	-0.4	-1.4	-0.8	-0.8	0.8
Whole body fat-free mass	0.4	2.2	4.5	1.5	0.0	-0.2	1.9	1.9	1.9	2.1	0.5	1.7	1.7	-0.4	1.9	1.0
Diabetes diagnosed by doctor	0.4	0.6	3.4	0.6	0.2	0.2	0.2	1.6	0.0	0.3	0.2	0.0	1.9	0.3	0.5	1.2
Eye problems/disorders: Cataract	0.4	0.5	1.7	0.7	0.7	0.4	0.5	0.6	0.5	0.7	0.7	0.4	1.3	0.6	0.6	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.3	-1.1	-0.9	-0.7	-0.5	-1.1	-0.3	-0.4	-0.8	-0.2	-1.4	-1.1	-0.6	-1.5
Whole body water mass	0.4	2.2	4.5	1.5	0.0	-0.2	1.9	1.9	1.9	2.1	0.5	1.7	1.7	-0.3	1.9	1.2
Financial situation satisfaction	0.4	0.6	1.2	-0.7	0.2	-0.8	-0.9	-0.9	-0.9	-0.7	-0.3	-0.2	-0.9	-0.2	-1.1	1.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.3	0.8	1.1	0.4	0.3	0.6	0.1	0.6	0.8	1.0	0.2	1.1	0.3	0.9
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.3	-0.1	-0.9	-1.4	0.2	1.5	0.1	-0.7	-0.6	-0.4	0.1	-0.5	0.3	0.8
Arm fat-free mass (left)	0.4	2.2	4.9	1.6	0.2	-0.0	1.7	1.8	1.6	2.2	0.6	1.8	1.4	-0.1	1.8	2.0
Heart attack/myocardial infarction (self-reported)	0.4	0.5	3.6	0.5	-0.4	-0.4	0.2	1.3	0.2	-0.2	0.1	-0.1	0.4	0.6	0.5	1.9
Arm predicted mass (left)	0.4	2.3	4.8	1.6	0.3	0.1	1.8	1.8	1.7	2.2	0.7	1.9	1.4	-0.1	1.8	1.8
Height	0.3	6.7	23.2	0.0	-4.3	-2.8	1.0	0.8	1.3	1.7	-2.3	-0.2	-1.5	-4.8	0.7	-4.8
Waist Hip Ratio (WHR)	0.3	1.1	7.1	0.4	0.3	0.1	1.0	2.7	1.0	1.8	0.4	0.5	0.2	-0.1	1.2	-0.4
Taking other prescription medications	0.3	0.5	3.6	-0.1	1.0	-0.3	-0.4	1.1	-0.5	-0.5	0.0	0.1	-0.1	0.4	-0.0	1.9
Qualifications: None of the above	0.3	0.7	3.8	0.3	-0.4	-0.3	-0.8	-0.3	-1.4	-0.3	-0.3	-0.4	-1.4	0.6	-0.5	1.9
Impedance of arm (right)	0.3	1.2	6.1	-0.6	-1.3	-0.3	-0.2	1.1	0.0	-0.2	-0.8	-1.7	-1.0	-1.2	-0.0	-2.5
Trunk fat-free mass	0.3	1.6	3.7	1.2	-0.3	-0.5	1.7	1.4	1.8	1.9	0.3	1.6	1.3	-0.6	1.6	0.7
Time employed in main current job	0.3	0.4	2.0	0.8	-0.0	1.0	0.3	-0.1	0.1	0.1	0.4	-0.1	1.4	0.4	0.4	0.6
Happiness	0.3	0.4	1.2	0.4	-0.1	-0.0	-0.0	-1.1	-0.3	-0.5	0.2	1.0	0.1	0.9	-0.2	1.1
Illnesses of mother	0.3	0.4	1.4	-0.4	-0.5	-0.4	-0.6	-1.2	-0.7	-0.5	-0.3	-0.4	-0.9	-0.1	-0.5	-0.5
Pulse wave Arterial Stiffness index	0.3	0.4	0.8	0.9	0.6	0.8	0.6	0.1	0.5	0.6	0.7	0.3	0.8	0.3	0.7	0.4
Impedance of arm (left)	0.3	1.3	5.3	-0.7	-1.3	-0.3	-0.4	0.9	-0.3	-0.6	-1.0	-1.9	-1.4	-1.2	-0.3	-2.3
Trunk predicted mass	0.3	1.7	3.7	1.2	-0.2	-0.4	1.7	1.3	1.8	1.9	0.3	1.6	1.4	-0.6	1.7	0.7
Breastfed as a baby	0.3	0.4	1.3	0.2	1.2	0.6	0.4	0.3	0.5	-0.1	0.6	0.3	1.1	0.6	0.5	0.4
Loud music exposure frequency	0.3	0.3	1.9	0.4	-1.4	0.0	-0.1	0.4	-0.2	-0.4	-0.3	-0.8	0.8	-0.7	-0.1	-0.0
Glaucoma (self-reported)	0.3	0.4	1.9	0.7	-0.1	-0.1	0.2	0.9	-0.1	0.0	0.3	-0.4	-0.3	0.9	0.5	1.4
Gout (self-reported)	0.3	0.4	1.5	-0.9	1.1	0.2	-0.5	-0.2	-0.3	-0.4	0.0	0.1	0.6	-0.4	-0.4	-1.2
Arm fat-free mass (right)	0.3	1.6	3.3	1.4	0.1	-0.1	1.5	1.4	1.4	1.8	0.3	1.6	1.2	-0.4	1.4	1.6
Comparative body size at age 10	0.3	0.8	3.2	0.9	0.1	0.5	0.7	0.9	0.5	0.5	0.6	0.6	1.8	0.9	0.7	1.4
Medication: Allopurinol	0.3	0.4	1.7	-0.7	0.5	-0.1	-0.6	-0.4	-0.4	-0.5	-0.3	-0.3	0.4	-0.6	-0.7	-1.3
Medication: Seretide 50 evohaler	0.3	0.4	1.3	-0.6	1.2	-0.0	-0.8	-0.1	-0.8	-0.6	0.0	-0.4	0.4	0.7	-0.7	0.0
Arm predicted mass (right)	0.3	1.3	2.9	1.2	-0.2	-0.3	1.4	1.3	1.3	1.7	0.1	1.4	1.1	-0.7	1.3	1.4
Comparative height size at age 10	0.3	1.8	6.8	-0.5	-2.5	-1.9	-0.1	1.2	0.2	0.7	-1.6	-1.1	0.0	-2.6	0.3	-1.1
Chest pain or discomfort	0.3	0.4	2.5	-0.2	0.1	-1.0	-0.5	1.6	-0.4	0.3	-0.5	-0.7	-0.1	-0.5	-0.0	0.6
Average weekly red wine intake	0.3	0.4	1.6	0.1	-0.4	0.5	0.4	1.3	0.6	0.3	-0.4	-0.8	0.7	-0.9	0.6	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.2	-0.8	0.3	-0.9	-0.4	-1.1	-0.3	-0.3	-0.1	0.0	-0.5	0.0	-0.4	-0.5
Qualifications: nursing, teaching	0.3	0.5	2.9	-0.6	1.7	0.6	-0.4	-0.3	-0.2	-0.8	0.4	0.4	0.5	0.6	-0.4	-0.4
Breast cancer (self-reported)	0.3	0.3	1.3	-0.4	0.0	-0.6	-0.6	-0.2	-0.8	-0.6	-0.5	-0.8	0.2	0.2	-0.5	1.1
Asthma (self-reported)	0.3	0.7	3.9	0.9	0.1	1.1	0.4	0.5	0.1	0.5	0.4	-0.4	1.1	0.6	0.6	2.0
Osteoporosis (self-reported)	0.3	0.4	1.7	0.7	0.1	0.4	0.7	1.3	0.6	0.7	0.4	0.3	0.1	0.3	0.8	-0.4
Number of operations (self-reported)	0.3	0.5	1.2	0.6	0.3	0.4	0.8	1.1	0.8	0.4	0.5	0.7	0.2	0.4	0.9	1.0
Alzheimer’s Disease (in mother)	0.2	0.2	0.9	0.0	1.0	-0.1	0.2	0.4	0.4	-0.0	0.4	0.7	0.5	0.2	0.2	0.2
Bipolar Disorder (2011)	0.2	0.2	0.8	-0.5	-0.1	-0.6	-0.2	-0.5	0.0	-0.2	-0.4	0.2	-0.7	-0.2	-0.1	-0.9
Rheumatoid Arthritis	0.2	0.3	0.8	-0.7	-0.4	-0.2	-0.2	-0.8	0.0	-0.3	-0.7	0.0	-0.6	-0.7	-0.4	-0.9
Heel T-Score	0.2	1.4	3.9	-0.9	1.8	1.3	0.6	-1.5	1.4	0.7	0.4	2.0	1.1	0.4	0.4	-1.4
Relative age of first facial hair	0.2	0.4	1.4	0.1	0.4	-0.4	0.7	0.1	0.9	1.2	0.3	0.9	-0.4	0.0	0.5	-0.8
Supplements: Zinc	0.2	0.2	1.4	-0.4	-0.2	-1.2	-0.0	-0.1	0.3	0.1	-0.3	0.1	-0.5	-0.4	0.1	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.3	-0.2	0.1	-0.4	-0.5	0.2	-0.7	-0.3	-0.2	0.2	-1.0	0.0	-0.5	1.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	1.4	0.4	-0.4	-0.6	0.1	0.2	0.0	0.3	0.1	-0.1	-0.5	-1.2	-0.1	-0.7
Had menopause	0.2	0.3	1.3	0.2	0.3	1.2	0.4	0.5	0.5	0.8	0.1	0.6	-0.1	0.1	0.6	-0.4
Financial difficulties in last 2 years	0.2	0.3	2.5	-0.2	0.8	0.1	0.1	0.9	0.1	-0.1	0.1	0.2	0.1	0.1	-0.0	1.6
Number of live births	0.2	0.3	1.7	0.2	1.3	0.0	0.1	0.1	0.1	0.5	0.7	1.0	0.2	0.6	-0.0	-0.0
Pulse wave reflection index	0.2	0.3	0.9	0.7	-0.7	0.6	0.2	0.8	0.1	0.6	0.2	-0.3	-0.1	-0.1	0.5	0.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	2.0	-0.0	1.1	-0.1	0.1	1.4	0.4	0.1	0.3	0.2	0.7	-0.0	0.4	-0.2
Shortness of breath walking on level ground	0.2	0.2	0.6	-0.6	0.1	-0.4	-0.5	-0.6	-0.5	-0.8	-0.4	0.3	-0.1	0.2	-0.5	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.9	-0.0	-0.1	-0.0	-0.5	-0.9	-0.6	-0.3	-0.3	-0.2	-0.6	-0.3	-0.5	0.4
Number of full sisters	0.2	0.3	1.6	0.2	-0.7	0.1	0.1	0.8	0.0	-0.1	-0.1	-0.2	-1.3	-0.3	-0.0	-1.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.7	-0.2	-0.4	-0.3	-0.6	-0.1	-0.7	-0.1	-0.3	-0.8	0.9	-0.3	-0.7	0.1
Osteoarthritis (self-reported)	0.2	0.2	0.6	-0.8	0.1	-0.6	-0.7	-0.4	-0.7	-0.1	-0.3	-0.1	-0.1	-0.0	-0.4	0.6
Illnesses of father: None of the above (group 1)	0.2	0.3	1.2	0.1	-1.1	0.4	0.3	-0.0	0.3	0.3	-0.4	-0.5	0.8	-0.6	0.3	-0.6
Average weekly champagne plus white wine intake	0.2	0.2	0.9	0.1	-0.2	0.6	0.4	0.3	0.4	-0.1	0.0	1.0	-0.3	-0.0	0.4	-0.8
Miserableness	0.2	0.4	0.9	-0.5	0.4	-0.9	-0.5	0.4	-0.5	-0.5	-0.6	-0.3	-0.8	-1.0	-0.7	-0.1
Ever taken oral contraceptive pill	0.2	0.3	0.6	-0.5	0.1	-0.0	-0.4	0.5	-0.4	-0.6	-0.6	-0.8	-0.2	-0.6	-0.4	0.7
Ever had prostate specific antigen (PSA) test	0.2	0.2	1.3	-0.4	0.3	0.7	-0.3	-1.2	-0.4	0.2	-0.1	-0.0	0.2	0.4	-0.3	-0.5
Ever depressed for a whole week	0.2	0.2	1.2	0.3	-0.2	0.0	0.0	0.4	-0.2	-0.3	0.1	0.5	0.6	0.5	0.1	1.1
Alzheimer’s Disease (including proxy)	0.1	0.2	0.6	-0.4	0.4	-0.8	-0.2	-0.1	-0.0	-0.7	-0.2	0.3	-0.5	-0.5	-0.2	-0.5
Age at First Birth	0.1	0.2	0.8	0.0	0.5	0.9	0.3	-0.3	0.4	0.2	0.2	0.2	-0.2	0.6	0.2	-0.2
Coronary Artery Disease (CAD)	0.1	0.1	0.2	0.3	-0.4	-0.2	0.5	-0.0	0.5	0.3	-0.1	0.4	0.3	-0.3	0.4	-0.4
Blood Platelet Count	0.1	1.4	9.5	0.9	-3.1	-0.2	0.7	-0.3	0.7	1.2	-0.7	-0.4	-0.5	-1.4	0.1	-1.7
Lung FEV1/FVC ratio	0.1	0.7	3.1	0.4	-0.3	1.4	0.8	0.0	0.7	1.8	0.3	0.9	-0.8	0.0	0.7	-0.5
Tanning	0.1	1.7	3.2	-1.4	-1.6	-1.5	-1.5	-1.4	-1.6	-1.1	-1.6	-1.8	-0.7	-0.9	-1.0	-0.0
Diabetes (father)	0.1	0.2	1.0	-0.5	0.2	0.0	-0.5	-1.0	-0.5	0.1	-0.3	-0.1	-0.2	0.2	-0.4	0.5
Diabetes (mother)	0.1	0.1	0.4	-0.4	0.2	-0.5	-0.3	0.0	-0.3	-0.3	-0.5	-0.2	0.4	-0.6	-0.2	0.4
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.5	0.1	0.3	-0.1	0.2	-0.7	0.2	-0.2	0.2	0.0	-0.0	0.7	-0.1	0.1
Noisy workplace	0.1	0.2	0.9	-0.1	-0.2	0.1	-0.3	-0.9	-0.4	-0.3	0.1	-0.3	-0.1	0.3	-0.5	-0.5
Birth weight of first child	0.1	0.2	1.6	-0.4	1.2	0.2	-0.1	0.3	0.1	-0.3	0.2	0.4	1.0	-0.3	-0.1	-0.2
Blood clot in the leg (DVT)	0.1	0.2	0.4	-0.3	-0.4	-0.3	-0.3	-0.3	-0.2	-0.2	-0.3	-0.7	-0.1	-0.5	-0.5	-0.6
Heart disease (mother)	0.1	0.2	0.5	0.3	-0.1	0.3	0.6	0.4	0.5	0.3	-0.0	0.5	0.1	0.1	0.7	0.7
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.9	0.4	-0.9	-0.2	0.3	0.4	0.2	0.1	0.0	0.0	-0.1	0.0	0.1	-0.3
Medication: Gliclazide	0.1	0.1	0.4	-0.1	-0.2	-0.7	-0.1	0.1	-0.1	-0.1	-0.3	0.0	0.0	-0.4	-0.1	-0.1
Average weekly beer plus cider intake	0.1	0.1	0.3	0.5	0.5	0.0	-0.0	0.3	-0.2	0.3	0.3	-0.3	0.1	0.1	-0.2	0.3
Unable to work because of sickness or disability	0.1	0.1	0.6	0.4	0.1	0.0	0.2	0.8	0.1	-0.4	0.1	-0.4	0.6	0.5	-0.1	0.0
Supplements: Calcium	0.1	0.2	0.7	-0.1	0.9	-0.4	0.2	0.6	0.3	-0.1	0.3	-0.1	-0.2	0.1	0.4	0.7
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.4	-0.2	-0.4	-0.1	-0.1	-0.2	-0.1	-0.0	-0.2	-0.6	0.1	-0.5	-0.4	-0.6
Hair Pigment	0.0	0.4	1.7	-0.4	-0.6	-0.3	-0.6	-0.0	-0.7	-1.0	-0.3	-0.4	-1.0	-0.0	-0.4	1.3
Commuting to job workplace: Walk	0.0	0.1	0.3	-0.1	0.6	-0.0	0.0	-0.3	0.1	-0.1	0.2	0.1	-0.3	0.2	-0.0	0.3

Hub : Genes

CIRH1A

Models

Trait associations