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chr20:61,522,825-62,912,463

Best TWAS P=5e-20 · Best GWAS P=2.17e-17 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Artery Aorta	OPRL1	0.27	0.19	lasso	4	0.17	1.4e-09	-8.3	-9.2	5.0e-20	-0.80	0.00	1.00	TRUE
7	GTEx	Artery Aorta	TCEA2	0.09	0.04	lasso	3	0.03	1.3e-02	-8.3	8.9	5.4e-19	0.76	0.00	0.99	TRUE
26	GTEx	Stomach	OPRL1	0.36	0.23	enet	16	0.19	1.3e-09	-8.3	-8.2	1.7e-16	-0.75	0.00	1.00	TRUE
46	The Cancer Genome Atlas	Stomach Adenocarcinoma	RGS19	0.13	0.10	enet	5	0.11	1.8e-08	7.0	-7.1	1.2e-12	-0.63	0.06	0.93	TRUE
1	CommonMind	Brain Pre-frontal Cortex	TPD52L2	0.13	0.07	bslmm	418	0.08	4.5e-10	-4.9	6.8	1.1e-11	0.27	0.99	0.00	TRUE
13	GTEx	Breast Mammary Tissue	GMEB2	0.18	0.02	lasso	5	0.06	3.0e-04	-3.6	-5.2	2.2e-07	-0.13	0.16	0.04	TRUE
25	GTEx	Skin Sun Exposed Lower leg	RGS19	0.42	0.26	lasso	6	0.33	4.6e-28	-8.3	-8.9	6.5e-19	-0.95	0.00	1.00	FALSE
22	GTEx	Pancreas	OPRL1	0.39	0.27	lasso	5	0.32	6.9e-14	-8.3	-8.8	1.1e-18	-0.90	0.00	1.00	FALSE
15	GTEx	Cells Transformed fibroblasts	RGS19	0.37	0.28	lasso	8	0.29	3.2e-22	8.4	-8.7	3.4e-18	-0.93	0.00	1.00	FALSE
17	GTEx	Esophagus Mucosa	RGS19	0.43	0.28	enet	17	0.34	7.9e-24	-8.3	-8.7	3.5e-18	-0.91	0.00	1.00	FALSE
24	GTEx	Skin Sun Exposed Lower leg	OPRL1	0.14	0.10	lasso	6	0.11	4.4e-09	8.4	-8.7	3.5e-18	-0.93	0.00	1.00	FALSE
21	GTEx	Nerve Tibial	OPRL1	0.20	0.15	lasso	3	0.14	3.3e-10	-8.3	-8.7	4.0e-18	-0.82	0.00	1.00	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	RGS19	0.07	0.05	blup	48	0.07	1.1e-07	-6.7	-8.7	4.1e-18	-0.79	0.02	0.98	FALSE
29	GTEx	Vagina	RGS19	0.39	0.08	lasso	8	0.03	7.5e-02	8.4	-8.6	8.7e-18	-0.91	0.01	0.88	FALSE
8	GTEx	Artery Tibial	OPRL1	0.10	0.10	lasso	2	0.06	1.1e-05	-8.3	-8.6	1.2e-17	-0.88	0.00	1.00	FALSE
28	GTEx	Thyroid	RGS19	0.23	0.14	enet	11	0.19	3.3e-14	8.4	-8.5	1.9e-17	-0.92	0.00	1.00	FALSE
30	GTEx	Whole Blood	OPRL1	0.09	0.06	enet	8	0.07	4.3e-07	8.5	8.5	2.9e-17	0.92	0.00	1.00	FALSE
27	GTEx	Stomach	RGS19	0.18	0.25	lasso	2	0.25	2.2e-12	-8.3	-8.3	7.1e-17	-0.84	0.00	1.00	FALSE
18	GTEx	Esophagus Muscularis	OPRL1	0.17	0.14	lasso	1	0.13	4.7e-08	-8.3	-8.3	7.6e-17	-0.84	0.00	1.00	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	OPRL1	0.03	0.02	lasso	1	0.01	3.5e-02	-8.3	-8.3	7.6e-17	-0.84	0.00	0.94	FALSE
9	GTEx	Artery Tibial	RGS19	0.12	0.07	lasso	2	0.07	2.8e-06	8.4	-8.3	8.7e-17	-0.95	0.00	1.00	FALSE
20	GTEx	Muscle Skeletal	RGS19	0.26	0.16	lasso	4	0.16	5.1e-15	8.4	-8.1	3.7e-16	-0.94	0.00	1.00	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	RGS19	0.51	0.28	enet	28	0.32	4.3e-18	-8.3	-8.1	4.1e-16	-0.80	0.00	1.00	FALSE
39	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RGS19	0.06	0.06	blup	47	0.05	1.4e-06	-8.3	-8.1	4.2e-16	-0.80	0.00	1.00	FALSE
33	YFS	Blood	OPRL1	0.07	0.07	lasso	5	0.09	5.0e-27	-8.3	8.0	1.0e-15	0.82	0.01	0.99	FALSE
5	GTEx	Adrenal Gland	RGS19	0.32	0.20	lasso	8	0.21	5.8e-08	-8.3	-7.9	2.0e-15	-0.79	0.00	0.99	FALSE
19	GTEx	Esophagus Muscularis	RGS19	0.22	0.10	lasso	4	0.10	1.6e-06	-8.3	-7.9	4.1e-15	-0.80	0.00	0.99	FALSE
12	GTEx	Brain Cerebellum	RGS19	0.28	0.22	lasso	4	0.18	7.2e-06	-8.3	-7.8	8.3e-15	-0.81	0.01	0.98	FALSE
4	GTEx	Adrenal Gland	OPRL1	0.48	0.29	enet	21	0.22	1.5e-08	-8.3	-7.8	8.5e-15	-0.78	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Breast Invasive Carcinoma	RGS19	0.03	0.02	blup	48	0.02	6.9e-06	7.0	-7.8	9.1e-15	-0.65	0.03	0.95	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	C20orf201	0.10	0.09	enet	9	0.10	9.9e-13	-6.7	7.6	2.0e-14	0.68	0.28	0.72	FALSE
10	GTEx	Brain Cerebellar Hemisphere	OPRL1	0.27	0.14	lasso	7	0.17	4.4e-05	-8.3	-7.6	2.4e-14	-0.77	0.01	0.88	FALSE
2	CommonMind	Brain Pre-frontal Cortex	ZBTB46	0.11	0.08	lasso	3	0.07	1.2e-08	-7.5	-7.6	4.1e-14	-0.24	0.84	0.15	FALSE
16	GTEx	Colon Sigmoid	RGS19	0.27	0.07	enet	33	0.09	3.8e-04	-6.8	-7.5	4.8e-14	-0.61	0.02	0.97	FALSE
43	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RGS19	0.11	0.00	blup	48	0.03	1.7e-02	7.0	-7.5	5.9e-14	-0.58	0.04	0.38	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	OPRL1	0.07	0.08	lasso	4	0.08	7.8e-09	-6.7	-7.5	6.5e-14	-0.68	0.20	0.80	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	ZBTB46	0.11	0.07	lasso	1	0.06	5.2e-08	-7.5	-7.5	7.7e-14	-0.24	0.85	0.15	FALSE
14	GTEx	Cells Transformed fibroblasts	OPRL1	0.25	0.07	enet	13	0.12	5.5e-09	5.5	-7.2	4.3e-13	-0.72	0.07	0.93	FALSE
42	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RGS19	0.05	0.02	blup	48	0.02	1.1e-03	4.7	-7.2	5.7e-13	-0.75	0.01	0.96	FALSE
47	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RGS19	0.18	0.08	enet	10	0.07	2.2e-03	4.7	-7.1	1.5e-12	-0.61	0.12	0.27	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	RGS19	0.07	0.04	blup	48	0.06	8.4e-07	5.5	-6.9	4.0e-12	-0.60	0.02	0.98	FALSE
3	GTEx	Adipose Subcutaneous	TCEA2	0.11	0.06	lasso	2	0.03	9.4e-04	6.7	6.9	4.8e-12	0.56	0.30	0.21	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	C20orf201	0.03	0.01	lasso	4	0.01	2.3e-03	-6.7	6.7	2.9e-11	0.61	0.31	0.16	FALSE
35	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RGS19	0.04	0.04	blup	48	0.03	1.1e-03	-8.3	-6.6	3.0e-11	-0.71	0.00	0.89	FALSE
38	The Cancer Genome Atlas	Colon Adenocarcinoma	RGS19	0.09	0.04	enet	4	0.04	2.8e-03	-6.3	-6.6	3.4e-11	-0.59	0.05	0.78	FALSE
11	GTEx	Brain Cerebellar Hemisphere	RGS19	0.36	0.10	lasso	5	0.07	8.2e-03	-6.7	-6.4	2.1e-10	-0.59	0.02	0.63	FALSE
40	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RGS19	0.12	0.05	blup	47	0.08	1.8e-05	-6.7	-6.3	3.8e-10	-0.37	0.10	0.44	FALSE
34	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C20orf201	0.05	0.00	enet	12	0.01	6.8e-02	3.5	5.2	2.0e-07	0.57	0.01	0.25	FALSE