Best TWAS P=5e-20 · Best GWAS P=2.17e-17 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TPD52L2 | 0.13 | 0.07 | bslmm | 418 | 0.08 | 4.5e-10 | -4.9 | 6.8 | 1.1e-11 | 0.27 | 0.99 | 0.00 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | ZBTB46 | 0.11 | 0.08 | lasso | 3 | 0.07 | 1.2e-08 | -7.5 | -7.6 | 4.1e-14 | -0.24 | 0.84 | 0.15 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | TCEA2 | 0.11 | 0.06 | lasso | 2 | 0.03 | 9.4e-04 | 6.7 | 6.9 | 4.8e-12 | 0.56 | 0.30 | 0.21 | FALSE |
| 4 | GTEx | Adrenal Gland | OPRL1 | 0.48 | 0.29 | enet | 21 | 0.22 | 1.5e-08 | -8.3 | -7.8 | 8.5e-15 | -0.78 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Adrenal Gland | RGS19 | 0.32 | 0.20 | lasso | 8 | 0.21 | 5.8e-08 | -8.3 | -7.9 | 2.0e-15 | -0.79 | 0.00 | 0.99 | FALSE |
| 6 | GTEx | Artery Aorta | OPRL1 | 0.27 | 0.19 | lasso | 4 | 0.17 | 1.4e-09 | -8.3 | -9.2 | 5.0e-20 | -0.80 | 0.00 | 1.00 | TRUE |
| 7 | GTEx | Artery Aorta | TCEA2 | 0.09 | 0.04 | lasso | 3 | 0.03 | 1.3e-02 | -8.3 | 8.9 | 5.4e-19 | 0.76 | 0.00 | 0.99 | TRUE |
| 8 | GTEx | Artery Tibial | OPRL1 | 0.10 | 0.10 | lasso | 2 | 0.06 | 1.1e-05 | -8.3 | -8.6 | 1.2e-17 | -0.88 | 0.00 | 1.00 | FALSE |
| 9 | GTEx | Artery Tibial | RGS19 | 0.12 | 0.07 | lasso | 2 | 0.07 | 2.8e-06 | 8.4 | -8.3 | 8.7e-17 | -0.95 | 0.00 | 1.00 | FALSE |
| 10 | GTEx | Brain Cerebellar Hemisphere | OPRL1 | 0.27 | 0.14 | lasso | 7 | 0.17 | 4.4e-05 | -8.3 | -7.6 | 2.4e-14 | -0.77 | 0.01 | 0.88 | FALSE |
| 11 | GTEx | Brain Cerebellar Hemisphere | RGS19 | 0.36 | 0.10 | lasso | 5 | 0.07 | 8.2e-03 | -6.7 | -6.4 | 2.1e-10 | -0.59 | 0.02 | 0.63 | FALSE |
| 12 | GTEx | Brain Cerebellum | RGS19 | 0.28 | 0.22 | lasso | 4 | 0.18 | 7.2e-06 | -8.3 | -7.8 | 8.3e-15 | -0.81 | 0.01 | 0.98 | FALSE |
| 13 | GTEx | Breast Mammary Tissue | GMEB2 | 0.18 | 0.02 | lasso | 5 | 0.06 | 3.0e-04 | -3.6 | -5.2 | 2.2e-07 | -0.13 | 0.16 | 0.04 | TRUE |
| 14 | GTEx | Cells Transformed fibroblasts | OPRL1 | 0.25 | 0.07 | enet | 13 | 0.12 | 5.5e-09 | 5.5 | -7.2 | 4.3e-13 | -0.72 | 0.07 | 0.93 | FALSE |
| 15 | GTEx | Cells Transformed fibroblasts | RGS19 | 0.37 | 0.28 | lasso | 8 | 0.29 | 3.2e-22 | 8.4 | -8.7 | 3.4e-18 | -0.93 | 0.00 | 1.00 | FALSE |
| 16 | GTEx | Colon Sigmoid | RGS19 | 0.27 | 0.07 | enet | 33 | 0.09 | 3.8e-04 | -6.8 | -7.5 | 4.8e-14 | -0.61 | 0.02 | 0.97 | FALSE |
| 17 | GTEx | Esophagus Mucosa | RGS19 | 0.43 | 0.28 | enet | 17 | 0.34 | 7.9e-24 | -8.3 | -8.7 | 3.5e-18 | -0.91 | 0.00 | 1.00 | FALSE |
| 18 | GTEx | Esophagus Muscularis | OPRL1 | 0.17 | 0.14 | lasso | 1 | 0.13 | 4.7e-08 | -8.3 | -8.3 | 7.6e-17 | -0.84 | 0.00 | 1.00 | FALSE |
| 19 | GTEx | Esophagus Muscularis | RGS19 | 0.22 | 0.10 | lasso | 4 | 0.10 | 1.6e-06 | -8.3 | -7.9 | 4.1e-15 | -0.80 | 0.00 | 0.99 | FALSE |
| 20 | GTEx | Muscle Skeletal | RGS19 | 0.26 | 0.16 | lasso | 4 | 0.16 | 5.1e-15 | 8.4 | -8.1 | 3.7e-16 | -0.94 | 0.00 | 1.00 | FALSE |
| 21 | GTEx | Nerve Tibial | OPRL1 | 0.20 | 0.15 | lasso | 3 | 0.14 | 3.3e-10 | -8.3 | -8.7 | 4.0e-18 | -0.82 | 0.00 | 1.00 | FALSE |
| 22 | GTEx | Pancreas | OPRL1 | 0.39 | 0.27 | lasso | 5 | 0.32 | 6.9e-14 | -8.3 | -8.8 | 1.1e-18 | -0.90 | 0.00 | 1.00 | FALSE |
| 23 | GTEx | Skin Not Sun Exposed Suprapubic | RGS19 | 0.51 | 0.28 | enet | 28 | 0.32 | 4.3e-18 | -8.3 | -8.1 | 4.1e-16 | -0.80 | 0.00 | 1.00 | FALSE |
| 24 | GTEx | Skin Sun Exposed Lower leg | OPRL1 | 0.14 | 0.10 | lasso | 6 | 0.11 | 4.4e-09 | 8.4 | -8.7 | 3.5e-18 | -0.93 | 0.00 | 1.00 | FALSE |
| 25 | GTEx | Skin Sun Exposed Lower leg | RGS19 | 0.42 | 0.26 | lasso | 6 | 0.33 | 4.6e-28 | -8.3 | -8.9 | 6.5e-19 | -0.95 | 0.00 | 1.00 | FALSE |
| 26 | GTEx | Stomach | OPRL1 | 0.36 | 0.23 | enet | 16 | 0.19 | 1.3e-09 | -8.3 | -8.2 | 1.7e-16 | -0.75 | 0.00 | 1.00 | TRUE |
| 27 | GTEx | Stomach | RGS19 | 0.18 | 0.25 | lasso | 2 | 0.25 | 2.2e-12 | -8.3 | -8.3 | 7.1e-17 | -0.84 | 0.00 | 1.00 | FALSE |
| 28 | GTEx | Thyroid | RGS19 | 0.23 | 0.14 | enet | 11 | 0.19 | 3.3e-14 | 8.4 | -8.5 | 1.9e-17 | -0.92 | 0.00 | 1.00 | FALSE |
| 29 | GTEx | Vagina | RGS19 | 0.39 | 0.08 | lasso | 8 | 0.03 | 7.5e-02 | 8.4 | -8.6 | 8.7e-18 | -0.91 | 0.01 | 0.88 | FALSE |
| 30 | GTEx | Whole Blood | OPRL1 | 0.09 | 0.06 | enet | 8 | 0.07 | 4.3e-07 | 8.5 | 8.5 | 2.9e-17 | 0.92 | 0.00 | 1.00 | FALSE |
| 31 | ROSMAP | Brain Pre-frontal Cortex | ZBTB46 | 0.11 | 0.07 | lasso | 1 | 0.06 | 5.2e-08 | -7.5 | -7.5 | 7.7e-14 | -0.24 | 0.85 | 0.15 | FALSE |
| 32 | ROSMAP | Brain Pre-frontal Cortex | C20orf201 | 0.10 | 0.09 | enet | 9 | 0.10 | 9.9e-13 | -6.7 | 7.6 | 2.0e-14 | 0.68 | 0.28 | 0.72 | FALSE |
| 33 | YFS | Blood | OPRL1 | 0.07 | 0.07 | lasso | 5 | 0.09 | 5.0e-27 | -8.3 | 8.0 | 1.0e-15 | 0.82 | 0.01 | 0.99 | FALSE |
| 34 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C20orf201 | 0.05 | 0.00 | enet | 12 | 0.01 | 6.8e-02 | 3.5 | 5.2 | 2.0e-07 | 0.57 | 0.01 | 0.25 | FALSE |
| 35 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | RGS19 | 0.04 | 0.04 | blup | 48 | 0.03 | 1.1e-03 | -8.3 | -6.6 | 3.0e-11 | -0.71 | 0.00 | 0.89 | FALSE |
| 36 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C20orf201 | 0.03 | 0.01 | lasso | 4 | 0.01 | 2.3e-03 | -6.7 | 6.7 | 2.9e-11 | 0.61 | 0.31 | 0.16 | FALSE |
| 37 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RGS19 | 0.03 | 0.02 | blup | 48 | 0.02 | 6.9e-06 | 7.0 | -7.8 | 9.1e-15 | -0.65 | 0.03 | 0.95 | FALSE |
| 38 | The Cancer Genome Atlas | Colon Adenocarcinoma | RGS19 | 0.09 | 0.04 | enet | 4 | 0.04 | 2.8e-03 | -6.3 | -6.6 | 3.4e-11 | -0.59 | 0.05 | 0.78 | FALSE |
| 39 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RGS19 | 0.06 | 0.06 | blup | 47 | 0.05 | 1.4e-06 | -8.3 | -8.1 | 4.2e-16 | -0.80 | 0.00 | 1.00 | FALSE |
| 40 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | RGS19 | 0.12 | 0.05 | blup | 47 | 0.08 | 1.8e-05 | -6.7 | -6.3 | 3.8e-10 | -0.37 | 0.10 | 0.44 | FALSE |
| 41 | The Cancer Genome Atlas | Brain Lower Grade Glioma | OPRL1 | 0.03 | 0.02 | lasso | 1 | 0.01 | 3.5e-02 | -8.3 | -8.3 | 7.6e-17 | -0.84 | 0.00 | 0.94 | FALSE |
| 42 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RGS19 | 0.05 | 0.02 | blup | 48 | 0.02 | 1.1e-03 | 4.7 | -7.2 | 5.7e-13 | -0.75 | 0.01 | 0.96 | FALSE |
| 43 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RGS19 | 0.11 | 0.00 | blup | 48 | 0.03 | 1.7e-02 | 7.0 | -7.5 | 5.9e-14 | -0.58 | 0.04 | 0.38 | FALSE |
| 44 | The Cancer Genome Atlas | Prostate Adenocarcinoma | OPRL1 | 0.07 | 0.08 | lasso | 4 | 0.08 | 7.8e-09 | -6.7 | -7.5 | 6.5e-14 | -0.68 | 0.20 | 0.80 | FALSE |
| 45 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RGS19 | 0.07 | 0.05 | blup | 48 | 0.07 | 1.1e-07 | -6.7 | -8.7 | 4.1e-18 | -0.79 | 0.02 | 0.98 | FALSE |
| 46 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RGS19 | 0.13 | 0.10 | enet | 5 | 0.11 | 1.8e-08 | 7.0 | -7.1 | 1.2e-12 | -0.63 | 0.06 | 0.93 | TRUE |
| 47 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RGS19 | 0.18 | 0.08 | enet | 10 | 0.07 | 2.2e-03 | 4.7 | -7.1 | 1.5e-12 | -0.61 | 0.12 | 0.27 | FALSE |
| 48 | The Cancer Genome Atlas | Thyroid Carcinoma | RGS19 | 0.07 | 0.04 | blup | 48 | 0.06 | 8.4e-07 | 5.5 | -6.9 | 4.0e-12 | -0.60 | 0.02 | 0.98 | FALSE |