Hub : Genes

NADK2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.244	0.083	5.3e-03	0.019	NA	0.096	NA	0.082	7.5e-02	NA	4.9e-04	NA	1.2e-03
2	GTEx	Esophagus Mucosa	0.226	0.056	1.3e-05	0.026	NA	0.084	NA	0.045	7.0e-03	NA	2.9e-06	NA	5.5e-04
3	GTEx	Esophagus Muscularis	0.135	0.049	4.0e-03	0.094	NA	0.017	NA	0.067	2.5e-06	NA	3.2e-02	NA	6.7e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.8	1.3	1.9	1.2	-0.6	-1.4
Bipolar Disorder or Schizophrenia	1.0	2.4	3.2	1.3	-1.6	-1.8
Depressed Affect (Nagel 2018)	2.8	5.8	8.5	-2.9	1.6	2.5
Depression (Nagel 2018)	3.1	4.6	7.9	-2.8	1.1	2.2
Intelligence (Savage-Jansen 2018)	0.7	2.1	2.4	-1.5	-1.3	1.5
Neuroticism (Nagel 2018)	1.9	4.5	7.1	-2.7	1.6	1.9
Schizophrenia (2018)	0.5	1.1	1.7	0.6	-1.3	-1.2
Schizophrenia vs Biploar Disorder	0.1	0.2	0.3	0.5	-0.2	-0.4
Worry (Nagel 2018)	0.6	1.3	2.1	-1.5	1.1	0.6
Alzheimer’s Disease (in mother)	1.9	2.2	4.5	2.1	0.1	-1.4
Alzheimer’s Disease (in father)	2.8	3.0	4.5	1.0	-2.1	-1.9
Alzheimer’s Disease (including proxy)	2.2	3.2	4.9	2.2	-1.0	-1.9
Crohns Disease (2017)	0.4	0.9	2.2	0.6	1.5	-0.4
Irritable Bowel Disease (IBD)	0.2	0.4	0.9	-0.4	0.3	1.0
Ulcerative Colitis (UC)	0.4	0.7	1.6	-0.6	-0.4	1.2
Major Depression (MDD)	0.3	0.4	1.1	0.2	-1.1	0.1
Reaction Time	0.5	0.9	1.7	1.3	-0.0	-1.1
Verbal and Numeric Reasoning (VNR)	0.9	2.2	3.7	-1.7	-0.1	1.9
Breast Cancer	0.0	0.0	0.1	0.4	-0.1	0.1
Ovarian Cancer	2.0	2.7	3.9	2.0	0.4	-2.0
Prostate Cancer	1.6	2.3	3.8	-1.9	0.6	1.6
Age at First Birth	0.5	0.7	1.8	1.3	-0.5	-0.4
Bipolar Disorder (2011)	1.0	1.0	2.0	-1.4	-0.9	0.3
Body Mass Index (BMI) (2010)	1.0	1.3	2.0	-1.4	-0.1	1.4
Coronary Artery Disease (CAD)	0.6	0.8	1.1	-0.8	1.0	0.8
Crohns Disease (2012)	1.0	1.6	3.3	0.9	1.8	-0.8
Mean Putamen Volume	0.5	0.6	1.4	0.4	0.3	-1.2
Fasting Glucose	1.7	2.0	4.6	2.1	-0.2	-1.2
HbA1C	1.2	1.3	1.9	-1.3	1.4	0.6
HDL Cholesterol	0.3	0.6	0.9	0.9	0.2	-0.9
LDL Cholesterol	0.5	0.8	1.6	1.3	-0.0	-0.8
Lupus	0.0	0.0	0.0	0.2	-0.2	0.0
Neuroticism (2016)	0.6	0.9	1.8	-0.9	1.4	0.2
Primary Biliary Cirrhosis	1.3	1.8	3.5	-1.4	-0.1	1.9
Rheumatoid Arthritis	0.1	0.1	0.3	0.1	0.6	-0.2
Schizophrenia (2014)	0.8	1.7	3.3	1.0	-0.8	-1.8
Triglycerides	0.6	1.0	1.5	1.1	0.4	-1.2
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.1	0.1	1.4	-0.7
Ulcerative Colitis	1.0	1.4	2.0	-1.3	-0.8	1.4
Blood Eosinophil Count	0.4	2.9	5.9	-0.3	-2.4	1.6
Blood Platelet Count	0.0	0.4	0.8	0.6	0.4	-0.9
Blood Red Count	0.3	3.0	8.4	-0.5	-2.9	-0.6
Blood White Count	0.4	3.1	7.3	-2.7	-0.3	1.3
Heel T-Score	0.3	2.3	3.5	1.3	1.4	1.9
BMI	0.4	2.0	4.3	-1.3	-0.4	2.1
Height	1.1	21.3	34.3	-5.9	-0.6	5.4
Waist Hip Ratio (WHR)	1.1	4.8	11.6	1.7	-0.3	-3.4
Systolic Blood Pressure	0.2	1.0	2.7	-0.4	1.6	0.2
Smoking Status	0.1	0.3	0.6	0.1	0.5	-0.8
Allergy or Eczema	1.9	4.9	14.4	0.3	-3.8	-0.5
Cardiovascular Disease	0.8	2.6	7.5	-0.4	2.7	-0.1
Hypothyroidism (self reported)	0.7	1.6	2.9	-0.7	-1.7	1.2
Respiratory disease	1.4	3.2	7.2	1.5	-2.7	-0.2
Type 2 Diabetes (T2D) (2018)	1.8	3.3	5.3	2.3	-0.3	-2.1
Lung FEV1/FVC ratio	0.2	0.8	2.0	0.4	1.4	0.4
Lung FVC	0.2	1.3	2.7	-0.8	1.6	0.7
Neuroticism	3.0	7.1	9.1	-3.0	2.4	2.5
Chronotype (morning person)	0.8	1.8	3.3	1.8	1.3	-0.6
Hair Pigment	0.0	0.5	0.6	-0.6	-0.8	-0.7
Tanning	0.3	3.4	6.1	1.9	0.6	-2.5
Hand grip strength (left)	0.3	0.8	1.6	-1.3	-0.2	0.9
Number of treatments/medications taken	0.8	1.5	2.3	1.1	1.5	-0.9
Average weekly spirits intake	0.2	0.3	0.5	0.0	0.7	0.5
Sensitivity / hurt feelings	3.2	5.4	8.7	-1.9	3.0	2.0
Frequency of depressed mood in last 2 weeks	1.6	2.2	3.0	-1.7	1.2	1.5
Hearing difficulty/problems: Yes	3.0	4.6	6.0	-1.7	-2.5	2.2
Relative age of first facial hair	1.3	2.7	5.4	1.6	0.5	-2.3
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	2.7	-1.5	0.1	1.6
Ever used hormone-replacement therapy (HRT)	3.1	3.9	11.4	-0.0	3.4	0.5
Ever had hysterectomy (womb removed)	1.8	2.0	4.2	-2.0	1.1	0.8
Systolic blood pressure, automated reading	0.4	1.2	2.0	-1.4	1.2	0.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.9	0.0	0.4	-1.0
Angina	1.3	1.7	4.5	0.4	2.1	-0.6
Medication for hormone replacement therapy	1.7	1.9	4.2	1.1	2.1	-0.5
Vitamin and mineral supplements	0.2	0.3	0.8	-0.9	-0.2	0.4
Supplements: Zinc	0.2	0.2	0.3	0.5	0.4	-0.4
Medication: Co-codamol	0.4	0.5	1.4	-0.3	-1.2	-0.0
Medication: Metformin	0.5	0.7	1.3	0.8	1.1	-0.5
Diabetes (father)	0.3	0.4	0.5	0.7	0.1	-0.7
Diabetes (mother)	0.0	0.0	0.0	0.1	0.1	0.2
Severe depression (siblings)	0.4	0.5	1.4	0.2	-1.2	0.0
Pack years adult smoking proportion	0.1	0.1	0.2	-0.2	0.3	0.4
Impedance of leg (right)	1.9	9.4	17.3	3.3	0.1	-4.2
Leg fat-free mass (left)	2.1	11.2	17.7	-3.8	-1.1	4.2
Trunk fat percentage	0.1	0.3	0.5	-0.7	0.5	-0.2
Hand grip strength (right)	0.1	0.4	0.8	-0.4	-0.9	0.4
Townsend deprivation index at recruitment	1.3	1.9	2.8	1.6	-0.7	-1.7
Current tobacco smoking	0.1	0.2	0.4	-0.5	-0.6	0.0
Average weekly fortified wine intake	0.5	0.6	0.8	0.8	-0.9	-0.5
Maternal smoking around birth	1.1	1.6	2.6	1.4	-0.3	-1.6
Fed-up feelings	1.4	2.6	3.9	-1.9	0.5	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	2.7	3.6	7.2	-2.7	0.5	1.8
Relative age voice broke	0.5	0.8	1.8	-1.4	-0.7	-0.5
Taking other prescription medications	0.9	1.4	2.8	1.7	0.7	-0.9
Age when periods started (menarche)	0.8	1.9	3.3	-1.2	-1.8	1.0
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.7	-0.3	1.6	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	1.5	0.3	1.2	1.1
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.8	0.4	0.5	-1.3
Qualifications: CSEs or equivalent	1.1	1.4	4.1	-0.1	-2.0	-0.4
Serious illness, injury or assault to yourself	0.6	0.7	2.0	-0.4	1.4	0.3
High blood pressure	1.6	4.3	10.8	-1.4	3.3	0.5
Hayfever, allergic rhinitis or eczema	1.8	3.9	7.3	1.4	-2.7	-1.6
Multivitamins +/- minerals	0.2	0.3	0.4	0.7	0.7	0.1
Stomach or abdominal pain in last month	0.1	0.2	0.5	-0.7	0.2	-0.2
Supplements: Glucosamine	0.3	0.4	0.9	-0.9	0.2	0.4
Diverticular disease/diverticulitis (self-reported)	1.2	1.5	3.2	1.0	-0.3	-1.8
Medication: Atenolol	0.7	0.8	1.2	-0.7	1.1	0.9
Medication: Levothyroxine sodium	0.6	1.0	1.6	-0.4	-1.0	1.3
Sitting height	1.6	11.6	19.1	-3.7	1.4	4.4
Chronic bronchitis/emphysema (father)	1.4	1.6	2.2	1.0	-1.5	-1.2
High blood pressure (mother)	0.8	1.1	2.3	-0.9	1.5	0.3
Body mass index (BMI)	0.6	2.7	4.2	-2.0	-0.1	2.0
Impedance of leg (left)	2.1	10.2	18.1	3.5	0.6	-4.3
Leg predicted mass (left)	2.1	10.9	17.4	-3.7	-1.2	4.2
Trunk fat mass	0.3	1.5	3.3	-1.8	0.1	1.0
Waist circumference	0.2	0.9	1.9	-1.4	-0.2	0.8
Number of incorrect matches in round	0.2	0.4	0.7	-0.8	0.4	0.6
Past tobacco smoking	0.5	1.0	2.4	-0.0	-1.5	0.7
Alcohol usually taken with meals	1.6	2.6	4.0	-0.5	1.9	2.0
Nervous feelings	1.5	2.7	3.9	-2.0	1.7	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	3.1	-1.8	0.6	0.9
Hearing difficulty/problems with background noise	1.2	1.9	3.4	-1.6	0.0	1.8
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	-0.4	0.3	0.1
Had menopause	1.1	1.3	3.8	-0.3	1.9	-0.3
Had other major operations	0.1	0.1	0.2	0.3	-0.5	0.4
Forced vital capacity (FVC)	0.3	1.0	2.2	-0.6	0.7	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	1.2	0.8	1.1	0.7
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.1	-0.0	1.0	-0.9
Qualifications: None of the above	0.1	0.2	0.3	0.1	-0.3	-0.6
Financial difficulties in last 2 years	2.3	3.1	5.5	-1.1	-2.4	1.6
Mouth/teeth dental problems	0.6	1.0	1.5	-1.0	0.7	1.2
Heart attack	0.0	0.0	0.1	-0.2	0.2	0.1
Allergy	1.3	3.0	6.7	-1.3	2.6	0.9
Pain all over the body in last month	0.3	0.3	0.7	-0.3	-0.9	0.0
Diabetes (self-reported)	1.1	1.8	3.1	1.8	0.8	-1.3
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	2.7	1.6	-1.3	-1.2
Medication: Ramipril	0.3	0.4	1.1	-0.1	1.0	-0.4
Medication: Simvastatin	1.6	2.3	3.8	1.6	0.7	-2.0
Fluid intelligence score	1.5	3.0	4.7	-1.6	-1.4	2.2
Illnesses of siblings	0.6	0.8	1.8	-0.2	-1.4	0.8
Neuroticism score	2.9	6.0	7.6	-2.8	1.9	2.6
Weight	1.4	6.9	11.1	-3.3	-0.4	3.1
Impedance of arm (right)	1.2	5.4	8.5	2.8	-0.4	-2.9
Arm fat percentage (right)	0.1	0.5	1.1	-1.0	-0.1	0.6
Trunk fat-free mass	2.1	12.0	17.6	-4.2	-1.1	4.2
Hip circumference	1.5	6.3	10.0	-3.0	-0.3	3.2
Time employed in main current job	0.1	0.1	0.2	0.1	0.1	0.4
Alcohol intake versus 10 years previously	0.3	0.5	0.9	-0.7	-0.9	0.4
Father’s age at death	0.8	1.1	2.7	0.1	-1.6	-0.7
Worrier / anxious feelings	0.4	0.8	1.2	-0.7	1.1	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.3	-0.6	1.2	-0.3
Falls in the last year	1.1	1.6	2.2	-1.2	-1.0	1.5
Hair/balding pattern: Pattern 3	1.9	2.8	3.9	-1.6	-1.4	2.0
Number of live births	0.7	1.0	1.6	1.3	0.4	-1.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	3.5	-0.6	0.8	1.9
Pulse rate	0.4	0.6	1.1	0.6	-0.6	-1.1
Happiness	0.3	0.4	0.7	-0.9	0.1	-0.6
Noisy workplace	0.2	0.2	0.3	-0.3	-0.6	-0.5
Qualifications: A levels/AS levels or equivalent	0.6	1.4	3.6	0.7	1.9	-0.2
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	3.6	-1.9	-0.1	0.4
Mouth/teeth dental problems: Dentures	0.1	0.2	0.5	0.3	0.7	-0.4
Asthma	2.3	4.5	7.8	2.2	-2.8	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	1.0	0.0	0.1	1.0
Medication: Cholesterol lowering	1.2	1.8	4.7	0.5	2.2	-0.7
Depression (self-reported)	1.0	1.2	2.9	-0.7	-1.7	-0.6
Medication: Lansoprazole	0.4	0.5	0.7	0.7	-0.5	-0.8
Prospective memory result	0.1	0.1	0.2	-0.2	0.4	-0.3
Lung cancer (father)	2.5	2.9	8.7	-0.1	-3.0	0.3
Illnesses of mother	4.7	5.7	15.6	-1.1	-3.9	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.2	-0.5	0.4	1.5
Pulse wave Arterial Stiffness index	0.1	0.1	0.1	-0.2	-0.4	-0.2
Impedance of arm (left)	0.9	4.0	6.5	2.3	-0.1	-2.5
Arm fat mass (right)	0.5	2.1	4.0	-2.0	-0.2	1.6
Trunk predicted mass	2.2	12.7	18.6	-4.3	-1.1	4.3
Standing height	0.6	6.2	10.6	-3.3	-0.4	2.8
Length of working week for main job	0.1	0.1	0.2	0.5	0.1	0.1
Exposure to tobacco smoke at home	0.1	0.2	0.2	0.4	-0.3	-0.5
Breastfed as a baby	0.9	1.1	2.4	-1.6	0.8	0.4
Tense / ‘highly strung’	1.4	2.3	3.3	-1.7	1.8	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.3	0.3	1.1	-0.6
Hair/balding pattern: Pattern 4	1.2	2.8	4.8	-1.2	2.2	1.5
Birth weight of first child	4.2	7.5	9.8	-2.9	-3.1	2.1
Peak expiratory flow (PEF)	1.0	2.3	4.7	-1.1	1.0	2.2
Pulse wave reflection index	0.8	1.0	1.7	-1.3	-0.6	1.1
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	0.3	-0.5	-0.3
Loud music exposure frequency	1.6	1.8	4.2	-0.5	-2.0	0.9
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.4	0.7	1.2	-0.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.7	-0.2	-0.7	-0.8
Blood clot in the leg (DVT)	0.9	1.1	1.6	-0.9	1.0	1.2
Medication: Paracetamol	0.2	0.3	1.0	0.0	-1.0	-0.0
Headache pain in last month	0.2	0.4	1.1	0.0	-0.3	1.0
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	6.2	0.4	-2.5	0.4
Glaucoma (self-reported)	0.7	0.8	1.1	-0.7	-1.1	0.9
Gout (self-reported)	0.3	0.5	0.8	0.6	-0.5	-0.9
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.2	-0.4	-1.1	0.8
Medication: Amlodipine	1.0	1.4	2.5	-1.6	1.3	-0.1
Medication: Ventolin 100micrograms inhaler	0.8	1.0	1.6	1.1	-1.2	-0.5
Birth weight	0.7	1.5	1.8	-1.3	-1.3	0.9
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.1	1.4	1.0	-0.6
High blood pressure (siblings)	0.3	0.4	0.9	0.5	0.4	-1.0
Forced vital capacity (FVC), Best measure	0.1	0.3	1.0	-0.3	0.0	1.0
Body fat percentage	0.1	0.3	0.7	-0.8	0.6	-0.0
Leg fat percentage (right)	0.1	0.2	0.7	-0.8	0.1	0.1
Arm fat-free mass (right)	1.7	8.6	12.9	-3.6	-0.3	3.6
Exposure to tobacco smoke outside home	0.7	1.0	2.6	-0.4	1.6	0.5
Comparative body size at age 10	0.1	0.2	0.7	0.1	-0.2	0.8
Number of full brothers	0.1	0.1	0.2	-0.1	0.0	-0.4
Worry too long after embarrassment	0.6	1.1	1.5	-1.2	0.6	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.0	-1.4	-1.1	0.4
Wheeze or whistling in the chest in last year	0.4	0.7	2.1	0.1	-1.4	0.3
Number of children fathered	1.2	1.3	2.2	-0.8	-1.5	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.3	-0.1	1.2	-0.1
Age at first live birth	0.1	0.2	0.4	0.1	0.4	-0.6
Pulse wave peak to peak time	0.1	0.1	0.2	0.0	0.2	0.4
Health satisfaction	1.1	1.4	4.2	0.2	-0.1	-2.0
Shortness of breath walking on level ground	1.1	1.3	2.5	-1.6	-1.1	0.6
Qualifications: College or University degree	0.9	2.8	4.1	-0.4	2.0	2.0
Eye problems/disorders: None of the above	2.3	2.6	5.8	2.4	-0.7	-1.3
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.1	-0.9	1.0	0.4
Emphysema/chronic bronchitis	0.7	0.8	1.5	0.9	-1.2	-0.2
Medication for pain relief, constipation, heartburn	0.2	0.3	0.8	0.1	0.5	-0.9
Neck or shoulder pain in last month	1.6	2.3	4.0	1.7	2.0	-0.2
Medication: Blood pressure	1.0	1.8	4.6	-0.8	2.1	-0.2
Angina (self-reported)	1.5	1.9	5.3	0.5	2.3	-0.5
Migraine (self-reported)	0.5	0.7	1.5	-0.4	1.2	0.6
Medication: Ibuprofen	0.3	0.3	0.7	0.4	0.8	0.4
Medication: Allopurinol	0.7	1.0	2.2	0.9	-0.1	-1.5
Medication: Omeprazole	2.1	2.5	4.7	-1.7	-0.1	2.2
Medication: Seretide 50 evohaler	1.4	1.6	2.1	1.4	-1.0	-1.4
Mean time to correctly identify matches	0.6	1.2	1.4	1.0	1.1	-1.2
Heart disease (mother)	2.3	2.9	8.1	0.6	2.9	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.1	-0.3	0.2	-0.3
Whole body fat mass	0.4	1.6	3.4	-1.9	-0.0	1.2
Leg fat mass (right)	0.5	1.8	3.8	-1.9	-0.1	1.3
Arm predicted mass (right)	1.8	9.2	14.1	-3.7	-0.5	3.8
Pulse rate, automated reading	0.1	0.3	0.8	-0.9	0.2	0.3
Alcohol intake frequency.	0.4	1.0	1.9	-0.3	-1.4	1.0
Comparative height size at age 10	1.0	5.7	10.2	-3.2	0.7	2.6
Number of full sisters	2.1	2.6	6.8	-1.0	-2.6	-0.1
Suffer from ‘nerves’	0.2	0.3	0.8	-0.4	0.4	0.9
Overall health rating	0.3	0.6	1.5	-0.5	-0.1	-1.2
Chest pain or discomfort	1.5	2.1	4.7	-2.2	0.1	1.3
Had major operations	3.7	4.3	6.7	-2.6	0.6	2.4
Age at last live birth	1.0	1.5	2.2	1.3	0.9	-1.5
Family relationship satisfaction	0.4	0.5	1.5	0.0	0.0	-1.2
Leg pain on walking	1.5	1.9	2.4	-1.5	1.6	1.0
Qualifications: NVQ or HND or HNC or equivalent	2.1	2.5	4.7	0.9	-2.2	-1.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.3	0.0	-0.5	-0.5
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	0.1	-0.2	0.2
Medication: Aspirin	0.3	0.5	0.7	-0.7	0.4	0.8
Supplements: Vitamin C	0.3	0.4	0.9	-0.4	-0.9	0.1
Knee pain experienced in last month	1.2	1.8	5.3	-0.2	2.3	0.3
Hypertension (Self-reported)	1.4	3.9	9.5	-1.4	3.1	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.8	3.8	-1.3	0.2	2.0
Illnesses of father: Heart disease	0.6	0.9	2.6	0.1	1.6	-0.1
Illnesses of siblings: Diabetes	0.6	0.8	0.8	-0.9	-0.8	0.9
Smoking status: Previous	0.9	1.4	3.8	0.0	1.9	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	1.9	-1.4	-1.2	1.2
Whole body fat-free mass	2.1	12.2	18.7	-4.2	-0.9	4.3
Leg fat-free mass (right)	2.0	10.9	18.5	-3.7	-0.8	4.3
Arm fat percentage (left)	0.2	0.7	1.4	-1.2	-0.1	0.9
Average weekly red wine intake	0.8	1.2	2.6	0.9	1.6	-0.3
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.4	0.1	-1.2	-0.2
Mood swings	0.9	1.6	1.8	-1.4	1.2	1.3
Loneliness, isolation	1.3	1.8	3.9	-2.0	0.8	0.9
Long-standing illness, disability or infirmity	0.4	0.7	1.1	1.0	-0.1	-1.0
Ever had bowel cancer screening	0.4	0.4	1.0	-0.1	0.5	-1.0
Diabetes diagnosed by doctor	0.1	0.2	0.4	0.6	0.3	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.8	-0.5	0.9	0.8
Friendships satisfaction	1.0	1.3	2.2	-1.2	-1.5	-0.5
Qualifications: nursing, teaching	0.7	1.1	3.3	-0.3	1.8	0.3
Commuting to job workplace: Walk	0.5	0.5	0.7	-0.9	0.7	0.7
Eye problems/disorders: Cataract	0.4	0.5	1.4	-1.2	-0.1	0.3
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.0	1.4	-0.9	-0.5
Medication for cholesterol	0.5	0.7	1.8	-0.2	-1.4	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	0.0	-0.6	-0.3
Back pain experienced in last month	1.1	1.6	2.0	-0.9	1.4	1.4
Mineral and other dietary supplements	1.5	2.0	4.2	-0.6	-2.1	1.1
Breast cancer (self-reported)	1.2	1.5	2.6	0.9	-1.6	-1.0
Asthma (self-reported)	2.0	4.0	7.4	2.0	-2.7	-0.8
Osteoporosis (self-reported)	0.6	0.7	1.7	1.3	0.1	-0.7
Osteoarthritis (self-reported)	0.5	0.7	1.9	0.2	1.4	0.0
Medication: Aspirin	0.4	0.6	0.9	-0.6	0.6	1.0
Medication: Gliclazide	0.1	0.1	0.3	0.3	0.5	0.3
Illnesses of father: None of the above (group 1)	0.2	0.3	0.6	0.8	-0.3	-0.2
Smoking status: Current	0.1	0.1	0.1	-0.3	-0.4	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.1	1.1	1.4	-0.9
Whole body water mass	2.1	12.0	18.5	-4.1	-0.9	4.3
Leg predicted mass (right)	2.0	10.6	17.9	-3.6	-0.8	4.2
Arm fat mass (left)	0.6	2.3	4.3	-2.1	-0.4	1.6
Number of self-reported non-cancer illnesses	0.7	1.2	2.1	-1.0	1.5	0.7
Average weekly champagne plus white wine intake	2.6	3.5	4.6	-1.6	1.8	2.2
Miserableness	2.2	3.8	5.9	-2.1	1.1	2.4
Guilty feelings	0.5	0.8	1.3	-1.1	0.9	0.4
Wears glasses or contact lenses	0.9	1.0	2.4	-1.5	0.8	0.3
Ever taken oral contraceptive pill	0.5	0.6	1.1	1.0	-0.2	-0.8
Hearing aid user	0.5	0.6	0.8	0.5	0.9	-0.8
Mother’s age at death	0.1	0.1	0.1	0.3	0.4	-0.2
Financial situation satisfaction	0.6	0.7	1.1	-0.9	-1.1	0.3
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.4	0.4	-1.2	0.1
Commuting to job workplace: Public transport	0.2	0.2	0.4	0.7	-0.5	-0.1
Eye problems/disorders: Glaucoma	0.3	0.4	0.7	-0.8	-0.1	0.7
Medication: Blood pressure	0.1	0.2	0.5	0.1	0.7	0.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.7	-0.4	0.4	-0.8
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.6	-0.6	1.9	-0.1
High cholesterol (Self-reported)	1.3	2.3	5.8	0.8	2.4	-0.7
Medication: Bendroflumethiazide	1.4	2.2	3.2	-1.8	0.5	1.7
Medication: Paracetamol	0.3	0.5	1.1	0.5	-1.1	-0.1
Medication: Lisinopril	0.7	0.9	1.6	-1.0	1.3	0.1
Medication: Atorvastatin	2.6	3.2	6.1	-1.8	0.6	2.5
Illnesses of father: High blood pressure	1.5	1.9	3.0	-1.7	0.5	1.6
Alcohol drinker status: Never	1.2	1.4	2.1	-1.4	-1.2	0.9
Ever smoked	0.1	0.2	0.4	0.2	0.6	-0.6
Basal metabolic rate	1.9	10.8	16.0	-3.9	-1.0	4.0
Leg fat percentage (left)	0.1	0.3	0.7	-0.8	0.5	0.3
Arm fat-free mass (left)	1.5	7.8	12.1	-3.5	-0.4	3.4
Number of operations (self-reported)	1.3	2.0	3.4	-1.4	-0.8	1.9
Average weekly beer plus cider intake	3.5	5.0	8.8	1.8	-1.7	-3.0
Irritability	0.9	1.5	1.6	-1.3	1.2	1.3
Risk taking	1.3	1.9	5.4	-0.4	2.3	-0.3
Ever had prostate specific antigen (PSA) test	1.3	1.5	1.8	-0.9	1.3	1.3
Fractured/broken bones in last 5 years	0.7	0.9	1.6	-0.9	1.3	0.6
Age started oral contraceptive pill	1.9	2.4	3.2	-1.0	1.8	1.7
Diastolic blood pressure, automated reading	0.2	0.6	1.2	-1.1	0.4	0.7
Ever depressed for a whole week	0.7	0.8	2.2	-0.2	1.5	-0.5
Unable to work because of sickness or disability	0.1	0.2	0.2	0.5	0.1	-0.5
Commuting to job workplace: Cycle	0.6	0.8	1.6	-0.4	-0.7	1.3
Myopia	1.1	1.7	2.6	1.5	0.4	-1.6
Vascular/heart problems diagnosed by doctor	1.4	3.9	10.0	1.2	-3.2	-0.4
Cholesterol lowering medication	0.8	1.2	2.4	1.6	0.6	-0.9
Medication: Omeprazole (e.g. Zanprol)	2.8	3.4	5.2	-2.2	-0.4	2.3
Pain experienced in last month	3.3	5.5	15.8	0.5	-4.0	-0.5
Supplements: Calcium	0.2	0.2	0.5	0.7	0.4	0.0
Basal cell carcinoma (self-reported)	0.8	1.0	2.9	-0.1	1.7	0.0
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.5	0.2	0.4
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.2	-0.7	1.1	1.1
Heart disease (siblings)	1.6	2.0	4.7	1.0	2.2	-0.5
Alcohol drinker status: Previous	0.8	0.9	1.3	0.8	1.1	-0.9
Pack years of smoking	0.2	0.2	0.5	-0.1	0.7	0.4
Impedance of whole body	1.6	8.1	14.2	3.2	0.4	-3.8
Leg fat mass (left)	0.5	1.9	3.8	-1.9	0.1	1.4
Arm predicted mass (left)	1.5	7.6	11.2	-3.3	-0.7	3.3