Hub : Genes

TRIM36

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0670	0.0270	0.0064	0.002	0.014	0.011	0.015	0.007	1.8e-01	7.2e-03	1.3e-02	0.0053	4.1e-02
2	METSIM	Adipose	0.0358	0.0181	0.0051	0.000	0.009	0.000	0.008	0.001	3.0e-01	1.2e-02	3.7e-01	0.0190	1.8e-01
3	TCGA	Thyroid Carcinoma	0.3730	0.0610	0.0000	0.383	0.350	0.373	NA	0.386	2.4e-39	2.5e-35	4.0e-38	NA	1.0e-39

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.9	3.0	5.6	0.3	-2.4	1.8
Bipolar Disorder or Schizophrenia	1.0	2.4	4.4	0.2	-2.1	1.7
Depressed Affect (Nagel 2018)	1.2	2.5	3.5	0.9	1.9	-1.8
Depression (Nagel 2018)	0.2	0.4	0.8	-0.9	0.3	0.4
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.2	-0.0	0.2	0.5
Neuroticism (Nagel 2018)	1.3	3.0	3.3	1.7	1.8	-1.7
Schizophrenia (2018)	0.2	0.4	0.6	0.0	-0.8	0.7
Schizophrenia vs Biploar Disorder	0.2	0.3	0.7	0.8	0.3	-0.5
Worry (Nagel 2018)	1.1	2.3	4.2	2.1	1.1	-1.2
Alzheimer’s Disease (in mother)	0.2	0.3	0.4	-0.6	0.6	0.1
Alzheimer’s Disease (in father)	0.7	0.8	1.3	1.1	-0.9	0.5
Alzheimer’s Disease (including proxy)	0.4	0.5	1.5	0.2	1.2	-0.1
Crohns Disease (2017)	1.4	3.1	5.2	1.6	1.2	-2.3
Irritable Bowel Disease (IBD)	1.9	4.6	10.1	1.5	1.1	-3.2
Ulcerative Colitis (UC)	1.6	3.0	6.2	1.6	0.4	-2.5
Major Depression (MDD)	0.9	1.1	2.7	1.6	0.0	0.8
Reaction Time	0.1	0.1	0.2	0.5	-0.3	0.0
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.2	-0.9	-0.1	1.1
Breast Cancer	0.4	1.0	2.0	1.0	1.4	0.1
Ovarian Cancer	0.3	0.4	0.7	0.1	0.7	-0.8
Prostate Cancer	0.6	0.8	2.2	1.5	0.4	-0.1
Age at First Birth	0.9	1.3	3.8	-0.2	2.0	-0.3
Bipolar Disorder (2011)	2.3	2.2	5.6	1.0	-2.4	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	-0.1	0.1	-0.2
Coronary Artery Disease (CAD)	0.5	0.6	0.8	-0.7	-0.8	0.9
Crohns Disease (2012)	2.4	3.9	6.2	1.5	1.8	-2.5
Mean Putamen Volume	0.2	0.3	0.5	-0.7	-0.5	-0.3
Fasting Glucose	0.7	0.9	1.4	-1.1	1.2	-0.2
HbA1C	2.1	2.3	3.0	1.2	1.7	-1.6
HDL Cholesterol	0.1	0.2	0.3	0.6	0.1	0.5
LDL Cholesterol	0.6	0.9	1.7	0.1	1.3	-1.0
Lupus	0.2	0.3	1.0	1.0	0.1	-0.2
Neuroticism (2016)	0.1	0.2	0.4	0.6	0.4	-0.3
Primary Biliary Cirrhosis	0.5	0.7	1.1	-0.7	0.7	-1.0
Rheumatoid Arthritis	1.4	2.0	4.3	0.5	-1.2	2.1
Schizophrenia (2014)	0.5	1.1	1.8	0.9	-1.3	0.9
Triglycerides	0.1	0.2	0.3	-0.5	0.5	-0.0
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.7	0.3	1.3	-0.2
Ulcerative Colitis	1.3	1.8	2.9	1.7	-0.3	-1.6
Blood Eosinophil Count	0.7	5.7	8.9	-0.9	-2.7	3.0
Blood Platelet Count	0.0	0.4	0.5	-0.2	0.7	-0.7
Blood Red Count	0.1	1.3	2.7	-1.6	-0.5	1.0
Blood White Count	0.2	1.7	3.8	-0.5	-1.9	1.0
Heel T-Score	0.1	0.5	0.7	0.3	-0.8	0.8
BMI	0.7	3.8	7.8	-0.4	-2.8	1.9
Height	0.6	11.7	31.0	0.7	-5.6	1.9
Waist Hip Ratio (WHR)	0.2	0.7	1.7	0.1	1.3	-0.7
Systolic Blood Pressure	1.2	6.2	15.0	-0.7	-3.9	1.8
Smoking Status	0.1	0.2	0.2	0.3	0.4	-0.5
Allergy or Eczema	0.0	0.0	0.1	0.4	0.1	0.0
Cardiovascular Disease	3.0	9.8	22.5	0.1	-4.7	2.6
Hypothyroidism (self reported)	0.6	1.3	2.2	0.7	-1.5	1.0
Respiratory disease	0.9	2.1	5.9	2.4	-0.5	0.5
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	-0.1	0.1	0.2
Lung FEV1/FVC ratio	0.1	0.8	1.3	1.1	-0.2	1.0
Lung FVC	0.1	0.3	0.5	0.4	0.6	-0.7
Neuroticism	1.1	2.7	4.0	2.0	1.9	-0.8
Chronotype (morning person)	3.7	8.4	13.2	1.7	3.6	-3.0
Hair Pigment	0.0	0.1	0.2	-0.3	0.1	-0.4
Tanning	0.2	2.3	4.2	-0.6	1.6	-2.0
Hand grip strength (left)	0.7	1.8	4.3	0.9	-2.1	0.5
Number of treatments/medications taken	4.4	7.9	17.0	-0.1	-4.1	2.6
Average weekly spirits intake	0.4	0.5	1.0	1.0	-0.6	-0.2
Sensitivity / hurt feelings	0.5	0.8	1.8	1.3	-0.6	-0.5
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.5	0.4	0.7	-0.1
Hearing difficulty/problems: Yes	0.2	0.3	0.5	0.4	-0.4	0.7
Relative age of first facial hair	0.8	1.7	3.2	-0.0	-1.8	1.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.8	0.9	-0.3	0.9
Ever used hormone-replacement therapy (HRT)	0.8	1.1	2.5	-1.6	0.4	-0.7
Ever had hysterectomy (womb removed)	1.1	1.2	1.9	-1.4	-1.2	0.5
Systolic blood pressure, automated reading	1.1	3.2	7.4	-1.0	-2.7	1.1
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	0.1	0.2	0.5
Angina	0.8	1.1	1.4	1.2	-0.8	1.2
Medication for hormone replacement therapy	0.5	0.6	1.4	-0.5	0.3	-1.2
Vitamin and mineral supplements	0.2	0.3	0.6	0.5	-0.7	0.1
Supplements: Zinc	0.2	0.2	0.4	0.5	0.2	-0.7
Medication: Co-codamol	0.5	0.6	1.6	0.4	-0.2	-1.2
Medication: Metformin	0.1	0.2	0.3	-0.5	0.3	0.5
Diabetes (father)	0.6	0.8	1.7	0.8	0.0	1.3
Diabetes (mother)	0.3	0.4	1.0	0.2	0.6	-1.0
Severe depression (siblings)	0.6	0.7	0.9	-0.8	-0.7	-1.0
Pack years adult smoking proportion	0.2	0.3	0.5	-0.6	0.0	0.7
Impedance of leg (right)	0.2	0.7	1.2	-1.1	0.7	-0.7
Leg fat-free mass (left)	0.6	3.3	6.0	0.6	-2.4	1.9
Trunk fat percentage	0.4	1.7	2.9	-0.3	-1.7	1.4
Hand grip strength (right)	0.8	2.1	4.1	1.2	-2.0	0.8
Townsend deprivation index at recruitment	0.1	0.1	0.2	0.4	0.3	-0.1
Current tobacco smoking	1.0	1.6	2.5	-0.0	1.5	-1.6
Average weekly fortified wine intake	0.8	1.0	2.1	-0.7	-1.4	-0.5
Maternal smoking around birth	0.9	1.3	2.5	-0.8	0.9	-1.6
Fed-up feelings	0.2	0.4	0.7	0.6	0.9	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	-0.9	0.6	0.3
Relative age voice broke	0.1	0.1	0.3	0.3	-0.0	-0.6
Taking other prescription medications	0.6	1.0	1.6	1.3	-0.9	0.7
Age when periods started (menarche)	1.2	2.9	4.2	0.6	2.0	-2.0
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	2.4	-0.1	0.5	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.0	0.7	-0.1	1.0
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	3.3	-1.8	-0.0	1.0
Qualifications: CSEs or equivalent	1.2	1.6	2.7	-1.6	-1.1	-0.9
Serious illness, injury or assault to yourself	0.4	0.5	0.9	0.3	-1.0	0.7
High blood pressure	4.2	11.6	26.0	-0.4	-5.1	3.0
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.5	0.5	-1.2	1.0
Multivitamins +/- minerals	1.0	1.3	3.0	-0.2	1.7	-0.9
Stomach or abdominal pain in last month	0.6	0.7	1.2	0.9	-0.3	-1.1
Supplements: Glucosamine	2.2	2.9	4.2	1.1	1.8	-2.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.3	0.4	0.4	-0.5
Medication: Atenolol	0.9	1.2	1.6	-1.2	-0.7	1.3
Medication: Levothyroxine sodium	1.2	2.0	3.7	1.9	-1.5	-0.3
Sitting height	0.4	2.6	2.8	-1.7	-1.6	1.6
Chronic bronchitis/emphysema (father)	1.1	1.3	3.3	1.8	0.7	-0.5
High blood pressure (mother)	0.3	0.5	1.3	-0.1	-1.1	0.4
Body mass index (BMI)	0.3	1.2	2.4	0.1	-1.6	1.1
Impedance of leg (left)	0.2	0.7	1.0	-0.7	1.0	-0.8
Leg predicted mass (left)	0.7	3.6	6.7	0.6	-2.6	1.9
Trunk fat mass	0.6	2.6	5.0	-0.1	-2.2	1.7
Waist circumference	0.7	2.6	5.5	0.4	-2.3	1.5
Number of incorrect matches in round	0.9	1.5	3.6	1.0	-1.9	0.1
Past tobacco smoking	0.0	0.1	0.1	-0.4	-0.0	-0.3
Alcohol usually taken with meals	3.2	5.2	7.2	-1.5	-2.5	2.7
Nervous feelings	1.5	2.7	6.0	2.4	0.8	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	0.9	0.8	-1.0	0.5
Hearing difficulty/problems with background noise	1.5	2.4	5.1	-1.0	-1.0	2.3
Hair/balding pattern: Pattern 2	1.4	1.8	3.1	-1.8	-1.0	1.1
Had menopause	0.2	0.2	0.3	-0.5	-0.4	0.5
Had other major operations	3.2	3.9	5.8	-2.0	-1.3	2.4
Forced vital capacity (FVC)	0.1	0.4	0.8	0.9	-0.7	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.2	0.1	0.1	0.4
Ever unenthusiastic/disinterested for a whole week	3.7	4.6	9.5	-0.6	-3.1	2.0
Qualifications: None of the above	0.8	1.6	4.6	-0.5	-2.2	-0.1
Financial difficulties in last 2 years	0.9	1.2	2.2	-1.5	1.1	-0.3
Mouth/teeth dental problems	1.4	2.2	5.5	-0.3	2.3	-1.0
Heart attack	0.1	0.1	0.1	0.3	0.3	0.4
Allergy	0.5	1.2	1.5	-1.2	1.2	-0.8
Pain all over the body in last month	2.2	2.4	5.3	2.3	-0.9	-1.0
Diabetes (self-reported)	0.7	1.1	1.6	-0.5	-1.3	1.2
Hayfever/allergic rhinitis (self-reported)	1.7	2.3	5.2	1.1	-2.3	0.8
Medication: Ramipril	0.9	1.2	2.3	-0.5	-1.5	1.0
Medication: Simvastatin	0.4	0.6	1.5	0.3	-1.2	0.5
Fluid intelligence score	0.2	0.5	0.6	-0.7	0.6	0.8
Illnesses of siblings	0.4	0.6	1.6	-0.5	1.3	-0.2
Neuroticism score	1.8	3.7	6.1	2.5	1.8	-1.4
Weight	0.7	3.5	7.4	0.4	-2.7	1.7
Impedance of arm (right)	0.0	0.2	0.4	-0.6	0.6	-0.1
Arm fat percentage (right)	0.4	1.5	2.8	-0.5	-1.7	1.2
Trunk fat-free mass	0.7	3.9	9.2	0.8	-3.0	1.4
Hip circumference	1.5	6.4	14.3	0.2	-3.8	2.2
Time employed in main current job	0.6	0.7	1.4	-0.5	-1.2	0.5
Alcohol intake versus 10 years previously	0.1	0.1	0.2	-0.4	-0.0	0.4
Father’s age at death	1.1	1.5	2.3	-0.5	1.4	-1.5
Worrier / anxious feelings	1.6	3.0	4.6	1.6	2.1	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	-0.3	0.0	0.6
Falls in the last year	1.3	1.7	4.1	1.0	-2.0	0.3
Hair/balding pattern: Pattern 3	0.4	0.6	1.1	1.0	0.7	-0.6
Number of live births	0.7	0.9	2.1	0.7	1.4	-0.4
Forced expiratory volume in 1-second (FEV1)	0.0	0.2	0.4	0.7	-0.2	0.0
Pulse rate	0.2	0.3	0.5	-0.7	-0.6	0.3
Happiness	1.1	1.3	3.2	-0.5	1.8	-0.6
Noisy workplace	0.4	0.5	1.2	0.7	-1.1	0.0
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.8	0.4	1.7	-0.8
Serious illness, injury or assault of a close relative in last 2 years	1.7	2.0	3.6	0.6	-1.9	1.4
Mouth/teeth dental problems: Dentures	1.4	2.4	4.1	2.0	-1.6	-0.6
Asthma	0.5	1.0	2.1	1.0	-1.4	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	1.5	-1.0	-0.9	1.2
Medication: Cholesterol lowering	2.8	4.4	7.6	1.0	-2.8	2.1
Depression (self-reported)	0.5	0.6	1.6	0.0	-0.6	1.2
Medication: Lansoprazole	0.4	0.4	1.1	1.1	-0.4	0.3
Prospective memory result	0.7	0.9	2.3	0.7	-1.5	0.1
Lung cancer (father)	0.7	0.8	1.2	1.1	-0.5	-1.0
Illnesses of mother	0.6	0.8	1.4	-0.2	-0.9	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.2	0.6	-1.1	0.6
Pulse wave Arterial Stiffness index	1.8	2.2	4.7	0.2	-2.2	1.3
Impedance of arm (left)	0.1	0.4	0.6	-0.8	0.3	0.7
Arm fat mass (right)	0.6	2.4	5.0	-0.1	-2.2	1.5
Trunk predicted mass	0.7	3.9	9.2	0.8	-3.0	1.4
Standing height	0.4	4.0	8.5	0.8	-2.9	1.7
Length of working week for main job	0.3	0.3	0.9	-0.1	1.0	-0.2
Exposure to tobacco smoke at home	1.3	1.5	2.8	-0.1	1.3	-1.7
Breastfed as a baby	0.1	0.1	0.4	-0.1	-0.1	0.6
Tense / ‘highly strung’	0.7	1.1	1.9	1.4	-1.2	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.8	0.9	-0.3	-0.2
Hair/balding pattern: Pattern 4	0.5	1.3	1.9	0.6	1.2	-1.4
Birth weight of first child	0.0	0.0	0.1	-0.0	0.3	-0.2
Peak expiratory flow (PEF)	0.1	0.3	0.8	-0.9	-0.2	0.0
Pulse wave reflection index	1.7	2.1	3.8	0.9	-2.0	1.3
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	-0.3	-0.3	0.1
Loud music exposure frequency	0.4	0.5	0.8	0.5	0.9	-0.6
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	5.0	2.2	-0.5	-0.1
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	1.7	-0.6	-1.1	1.3
Blood clot in the leg (DVT)	0.3	0.4	0.7	-0.2	-0.5	0.8
Medication: Paracetamol	2.0	3.3	5.0	-2.0	-2.2	1.1
Headache pain in last month	0.9	1.6	3.2	-0.0	-1.8	1.2
Medication for cholesterol, blood pressure or diabetes	4.6	7.5	13.9	-0.3	3.7	-2.9
Glaucoma (self-reported)	0.4	0.5	1.2	1.1	0.5	0.1
Gout (self-reported)	0.4	0.5	1.2	1.1	0.2	-0.6
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	2.6	1.3	-1.6	0.8
Medication: Amlodipine	2.2	3.1	4.8	-0.5	-2.1	2.2
Medication: Ventolin 100micrograms inhaler	0.4	0.4	1.1	1.1	-0.3	-0.3
Birth weight	0.1	0.2	0.4	0.0	-0.3	-0.6
Chronic bronchitis/emphysema (mother)	0.5	0.6	0.9	-0.9	0.8	-0.5
High blood pressure (siblings)	1.8	2.6	6.4	0.4	-2.5	1.1
Forced vital capacity (FVC), Best measure	0.1	0.5	1.5	0.3	-1.2	0.2
Body fat percentage	0.3	1.2	2.1	-0.2	-1.5	1.2
Leg fat percentage (right)	0.2	0.9	1.5	-0.7	-1.2	0.8
Arm fat-free mass (right)	0.6	3.2	6.7	0.9	-2.6	1.5
Exposure to tobacco smoke outside home	0.5	0.7	1.3	-1.1	-0.6	-0.6
Comparative body size at age 10	0.2	0.6	1.3	0.7	1.1	0.3
Number of full brothers	1.8	2.3	3.9	2.0	0.1	-1.7
Worry too long after embarrassment	2.4	4.0	5.7	2.4	2.1	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.4	3.8	1.9	-1.8	-0.1
Wheeze or whistling in the chest in last year	0.7	1.2	2.6	1.0	-1.6	0.0
Number of children fathered	0.2	0.2	0.4	-0.2	-0.6	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.4	0.7	0.1	-0.2
Age at first live birth	0.1	0.1	0.4	0.1	0.0	-0.6
Pulse wave peak to peak time	1.5	1.7	4.0	-0.3	2.0	-1.0
Health satisfaction	4.0	5.2	8.9	-0.5	-3.0	2.5
Shortness of breath walking on level ground	2.1	2.5	6.6	0.3	-2.6	0.9
Qualifications: College or University degree	0.4	1.3	3.8	-0.3	2.0	0.0
Eye problems/disorders: None of the above	1.6	1.8	2.6	-1.6	0.9	-1.4
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.7	-0.8	-0.1	-0.7
Emphysema/chronic bronchitis	0.5	0.6	0.7	0.7	-0.7	0.9
Medication for pain relief, constipation, heartburn	0.6	1.1	2.4	-0.4	1.5	-0.9
Neck or shoulder pain in last month	0.3	0.4	1.1	-1.1	0.0	0.2
Medication: Blood pressure	4.0	7.1	12.6	0.8	-3.5	2.9
Angina (self-reported)	1.1	1.5	2.1	0.9	-1.2	1.5
Migraine (self-reported)	0.8	1.0	1.4	-0.4	-1.2	1.2
Medication: Ibuprofen	1.5	1.8	3.1	-1.0	-1.2	1.8
Medication: Allopurinol	0.7	0.9	2.4	1.6	0.0	-0.5
Medication: Omeprazole	0.5	0.6	1.4	-0.3	0.5	-1.2
Medication: Seretide 50 evohaler	0.3	0.4	0.8	0.9	0.2	0.6
Mean time to correctly identify matches	0.5	0.9	1.2	0.9	-1.1	0.8
Heart disease (mother)	0.3	0.4	0.9	-0.9	0.0	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.3	-0.3	-1.1	-0.3
Whole body fat mass	0.6	2.7	5.4	-0.0	-2.3	1.6
Leg fat mass (right)	0.5	2.1	4.3	-0.0	-2.1	1.4
Arm predicted mass (right)	0.5	2.6	5.9	0.7	-2.4	1.2
Pulse rate, automated reading	0.4	1.3	1.7	-0.9	1.3	-1.2
Alcohol intake frequency.	1.8	4.1	9.0	-0.1	-3.0	1.8
Comparative height size at age 10	0.8	4.6	9.8	1.6	-3.1	1.1
Number of full sisters	0.4	0.5	1.3	-1.1	0.6	0.1
Suffer from ‘nerves’	2.5	4.0	6.9	2.6	1.9	-1.1
Overall health rating	0.3	0.6	0.9	-0.3	-0.9	1.0
Chest pain or discomfort	0.1	0.1	0.2	-0.1	-0.5	0.1
Had major operations	1.3	1.5	2.9	0.6	-1.2	1.7
Age at last live birth	0.7	1.0	2.0	-0.2	1.0	-1.4
Family relationship satisfaction	0.8	0.9	1.4	-1.2	-0.1	1.2
Leg pain on walking	2.7	3.4	8.1	-0.8	-2.9	1.2
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	3.9	0.3	2.0	-1.4
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.0	-0.5	-1.0	-0.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.6	0.1	-0.4	0.8
Medication: Aspirin	5.3	6.9	12.5	1.0	-3.5	2.7
Supplements: Vitamin C	0.7	0.8	1.2	-1.1	0.0	1.1
Knee pain experienced in last month	0.9	1.4	3.2	-0.1	-1.8	1.0
Hypertension (Self-reported)	3.8	10.7	24.9	0.1	-5.0	2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.5	-0.7	-0.7	-0.0
Illnesses of father: Heart disease	0.2	0.3	0.4	0.6	-0.3	0.7
Illnesses of siblings: Diabetes	0.2	0.2	0.5	0.7	0.2	0.4
Smoking status: Previous	0.4	0.6	1.1	-0.1	-0.8	1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	3.3	0.2	-1.8	1.8
Whole body fat-free mass	0.7	3.8	8.2	0.8	-2.9	1.6
Leg fat-free mass (right)	0.6	3.0	5.2	0.9	-2.3	1.8
Arm fat percentage (left)	0.4	1.5	2.5	-0.3	-1.6	1.4
Average weekly red wine intake	1.3	1.9	2.5	-1.1	-1.6	1.4
Handedness (chirality/laterality): Left-handed	1.0	1.2	1.4	-0.8	1.2	-1.2
Mood swings	2.1	3.9	8.2	0.7	1.7	-2.9
Loneliness, isolation	0.6	0.8	1.8	-0.4	1.4	0.6
Long-standing illness, disability or infirmity	0.4	0.5	0.9	0.0	-0.9	0.9
Ever had bowel cancer screening	0.4	0.5	1.3	0.3	-1.1	0.3
Diabetes diagnosed by doctor	0.7	1.1	1.6	-0.2	-1.3	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.0	-0.4	-1.4	0.7
Friendships satisfaction	0.4	0.5	1.2	-0.5	-0.4	1.1
Qualifications: nursing, teaching	0.4	0.6	1.4	0.2	0.6	-1.2
Commuting to job workplace: Walk	0.4	0.4	1.0	-1.0	0.3	0.4
Eye problems/disorders: Cataract	1.5	1.7	2.4	0.8	-1.4	1.5
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.8	-0.1	0.9	-0.9
Medication for cholesterol	0.3	0.4	0.6	0.7	0.4	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.7	-0.1	0.8	-0.2
Back pain experienced in last month	0.1	0.2	0.3	-0.4	0.6	-0.3
Mineral and other dietary supplements	0.1	0.1	0.2	-0.1	-0.5	0.1
Breast cancer (self-reported)	1.6	1.9	2.8	-1.7	-0.9	1.5
Asthma (self-reported)	0.5	1.1	2.1	1.0	-1.4	0.3
Osteoporosis (self-reported)	0.2	0.2	0.6	-0.2	-0.8	-0.2
Osteoarthritis (self-reported)	0.4	0.6	1.4	1.2	-0.4	0.3
Medication: Aspirin	4.1	5.3	9.3	0.7	-3.0	2.5
Medication: Gliclazide	2.3	2.6	5.2	-1.6	2.3	-0.3
Illnesses of father: None of the above (group 1)	0.7	0.9	2.2	-1.5	0.6	-0.5
Smoking status: Current	1.6	2.5	3.8	0.6	1.8	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.2	0.4	-0.5	-0.1
Whole body water mass	0.7	3.7	8.2	0.8	-2.9	1.5
Leg predicted mass (right)	0.6	3.1	5.3	0.9	-2.3	1.8
Arm fat mass (left)	0.5	1.9	4.2	-0.1	-2.1	1.2
Number of self-reported non-cancer illnesses	1.6	2.8	5.9	0.8	-2.4	1.3
Average weekly champagne plus white wine intake	0.4	0.5	1.6	-1.2	-0.2	0.2
Miserableness	0.1	0.2	0.4	-0.3	0.7	0.3
Guilty feelings	0.6	0.9	2.1	0.6	1.5	-0.5
Wears glasses or contact lenses	0.9	1.0	2.4	-1.6	-0.8	0.1
Ever taken oral contraceptive pill	0.2	0.2	0.5	-0.4	0.2	0.7
Hearing aid user	7.7	8.7	13.5	1.3	3.7	-3.3
Mother’s age at death	1.4	1.7	3.3	0.6	1.3	-1.8
Financial situation satisfaction	0.5	0.6	0.8	-0.7	0.6	-0.9
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.4	-1.8	0.8	-0.3
Commuting to job workplace: Public transport	0.4	0.5	1.5	0.1	-0.3	-1.2
Eye problems/disorders: Glaucoma	1.0	1.2	3.3	1.8	0.5	-0.4
Medication: Blood pressure	0.6	1.2	3.3	-0.5	-1.8	-0.4
Pain type(s) experienced in last month: Hip pain	1.5	1.8	3.1	-0.8	-1.4	1.8
Supplements: Fish oil (including cod liver oil)	2.1	2.7	4.3	0.6	-1.9	2.1
High cholesterol (Self-reported)	0.7	1.2	2.5	0.0	-1.6	1.0
Medication: Bendroflumethiazide	6.9	10.5	19.8	-1.7	-4.4	3.0
Medication: Paracetamol	2.3	3.6	6.4	-1.1	-2.5	1.8
Medication: Lisinopril	0.4	0.5	0.8	0.7	-0.9	-0.6
Medication: Atorvastatin	0.7	0.9	1.3	0.7	-1.0	1.2
Illnesses of father: High blood pressure	0.3	0.4	0.7	0.4	-0.5	-0.9
Alcohol drinker status: Never	1.2	1.4	3.9	-0.6	-2.0	0.2
Ever smoked	0.3	0.5	1.3	0.2	1.1	-0.5
Basal metabolic rate	0.7	3.8	8.2	0.7	-2.9	1.6
Leg fat percentage (left)	0.1	0.4	0.8	-0.3	-0.9	0.6
Arm fat-free mass (left)	0.6	2.8	7.2	0.5	-2.7	0.9
Number of operations (self-reported)	1.2	1.8	3.3	-0.2	-1.8	1.5
Average weekly beer plus cider intake	5.7	8.2	15.1	-0.1	3.9	-3.1
Irritability	0.8	1.3	3.6	1.9	0.6	-0.1
Risk taking	0.3	0.4	1.2	0.1	1.1	-0.1
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	0.5	-0.3	0.1
Fractured/broken bones in last 5 years	3.3	4.3	7.3	0.3	-2.3	2.7
Age started oral contraceptive pill	0.6	0.8	1.7	1.3	-0.1	-0.7
Diastolic blood pressure, automated reading	0.8	2.5	6.5	-0.7	-2.5	0.7
Ever depressed for a whole week	4.7	5.8	11.6	-1.1	-3.4	2.2
Unable to work because of sickness or disability	1.7	2.2	3.6	-0.3	-1.9	1.7
Commuting to job workplace: Cycle	0.4	0.4	1.0	1.0	-0.5	0.3
Myopia	0.3	0.4	1.0	-0.4	0.1	-1.0
Vascular/heart problems diagnosed by doctor	4.2	11.5	24.8	0.2	5.0	-3.1
Cholesterol lowering medication	0.3	0.4	0.9	0.1	0.5	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	0.2	0.6	-0.9
Pain experienced in last month	0.2	0.4	1.2	-0.1	1.1	0.2
Supplements: Calcium	0.9	1.0	1.7	-0.6	1.3	-1.0
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	-0.3	0.7	-0.0
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.4	0.3	0.6	0.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.2	-0.5	-0.9	1.1
Heart disease (siblings)	0.9	1.2	1.3	0.9	1.1	-1.2
Alcohol drinker status: Previous	1.1	1.2	2.6	0.6	-1.6	0.8
Pack years of smoking	0.2	0.3	0.6	-0.4	0.1	0.8
Impedance of whole body	0.1	0.7	1.3	-1.2	0.8	-0.3
Leg fat mass (left)	0.4	1.6	3.5	0.2	-1.9	1.2
Arm predicted mass (left)	0.5	2.6	6.6	0.8	-2.6	0.6