Hub : Genes

CCDC112

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0380	0.0180	6.5e-03	0.002	0.008	0.002	0.007	0.005	1.8e-01	3.5e-02	1.9e-01	0.0380	8.1e-02
2	METSIM	Adipose	0.0338	0.0186	2.3e-02	0.008	0.014	0.006	0.014	0.008	2.0e-02	2.6e-03	3.1e-02	0.0025	1.7e-02
3	YFS	Blood	0.0189	0.0107	1.1e-02	0.002	0.002	-0.001	0.003	0.000	4.6e-02	4.3e-02	9.0e-01	0.0280	2.4e-01
4	TCGA	Brain Lower Grade Glioma	0.1012	0.0464	3.4e-03	0.010	0.020	0.031	NA	0.007	2.4e-02	2.1e-03	1.7e-04	NA	4.2e-02
5	TCGA	Thyroid Carcinoma	0.1330	0.0410	1.0e-13	0.094	0.136	0.110	NA	0.138	1.9e-09	3.7e-13	8.3e-11	NA	2.3e-13

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.6	2.5	4.9	1.6	1.9	1.0	-0.5	2.2
Bipolar Disorder or Schizophrenia	1.5	3.6	5.8	2.4	2.2	2.0	0.4	1.8
Depressed Affect (Nagel 2018)	1.2	2.4	5.0	-1.8	-2.2	1.0	-0.7	-1.5
Depression (Nagel 2018)	0.7	1.1	2.0	-1.2	-1.2	1.4	0.7	-0.5
Intelligence (Savage-Jansen 2018)	1.0	3.1	10.1	1.4	3.2	-1.1	0.6	1.4
Neuroticism (Nagel 2018)	1.1	2.7	7.5	-1.9	-2.7	0.2	-0.9	-1.2
Schizophrenia (2018)	0.8	1.8	3.3	1.8	1.3	1.7	0.9	0.5
Schizophrenia vs Biploar Disorder	0.2	0.3	0.8	0.2	-0.9	0.2	0.7	-0.5
Worry (Nagel 2018)	0.6	1.2	2.9	-0.7	-1.7	-0.9	1.2	-0.7
Alzheimer’s Disease (in mother)	0.8	1.0	1.3	-1.0	-1.1	1.1	-1.1	-0.2
Alzheimer’s Disease (in father)	1.8	2.0	6.9	1.2	0.6	-0.8	2.6	0.7
Alzheimer’s Disease (including proxy)	0.7	1.1	2.7	-1.3	-1.6	0.7	0.7	-0.2
Crohns Disease (2017)	0.7	1.6	3.2	-1.1	-1.8	-1.3	-0.9	-1.1
Irritable Bowel Disease (IBD)	1.3	3.1	8.8	-0.7	-3.0	-1.2	-0.4	-2.2
Ulcerative Colitis (UC)	0.9	1.8	4.7	0.8	-2.2	-0.3	-0.2	-1.9
Major Depression (MDD)	2.1	2.5	5.7	1.8	2.4	1.0	0.3	1.5
Reaction Time	0.4	0.8	2.5	-1.6	0.3	-1.0	-0.3	0.5
Verbal and Numeric Reasoning (VNR)	1.3	3.0	9.4	1.4	3.1	-1.4	0.9	1.0
Breast Cancer	0.3	0.8	2.7	-0.2	-0.9	1.6	-0.0	0.5
Ovarian Cancer	0.9	1.2	2.7	-0.9	-0.6	-0.8	-1.6	-1.3
Prostate Cancer	0.6	0.8	1.7	1.3	1.0	0.1	-0.2	1.1
Age at First Birth	0.3	0.4	1.0	-0.5	0.2	0.4	0.9	-1.0
Bipolar Disorder (2011)	2.4	2.4	5.2	1.9	2.3	0.4	-0.7	1.5
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	-1.0	0.0	-0.2	-0.9	-0.1
Coronary Artery Disease (CAD)	0.2	0.3	1.1	0.3	0.2	-1.1	0.4	0.3
Crohns Disease (2012)	1.3	2.1	6.6	-1.4	-0.9	-0.9	-2.6	-0.7
Mean Putamen Volume	0.9	1.0	3.5	0.5	0.4	-1.9	-1.1	0.3
Fasting Glucose	2.2	2.7	8.3	-2.9	-1.3	0.1	0.6	-1.7
HbA1C	0.7	0.8	2.4	-0.4	0.7	-1.5	0.1	-1.0
HDL Cholesterol	0.1	0.2	0.8	-0.4	-0.1	0.0	0.9	-0.4
LDL Cholesterol	0.5	0.7	1.1	0.9	1.0	0.9	-1.0	-0.0
Lupus	0.2	0.4	0.8	0.6	-0.8	0.9	-0.3	0.1
Neuroticism (2016)	0.4	0.5	1.1	-1.0	-1.1	0.5	-0.5	-0.1
Primary Biliary Cirrhosis	0.7	1.1	1.9	-0.5	-1.3	-0.6	1.4	-1.1
Rheumatoid Arthritis	1.3	1.8	2.8	0.8	1.7	1.5	0.8	1.7
Schizophrenia (2014)	1.0	2.2	5.1	2.2	0.9	2.0	0.2	1.0
Triglycerides	0.3	0.5	1.4	-0.8	0.5	0.3	-1.2	0.6
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.7	-0.3	0.6	-0.9	0.3	-0.2
Ulcerative Colitis	0.6	0.9	3.0	0.7	-1.7	0.1	0.7	-0.6
Blood Eosinophil Count	0.3	2.6	6.9	0.1	0.4	1.7	-1.7	2.6
Blood Platelet Count	0.2	2.3	5.1	-1.6	-1.8	2.2	-0.3	-0.8
Blood Red Count	0.1	1.1	3.0	-1.7	-0.0	1.1	-0.3	1.0
Blood White Count	0.6	4.2	12.1	-0.4	-0.1	3.5	-2.9	0.5
Heel T-Score	0.1	1.1	2.9	-0.6	-1.7	0.2	1.3	0.9
BMI	0.1	0.9	1.2	1.1	0.4	-0.9	-0.9	1.1
Height	1.0	20.2	61.5	6.0	0.6	7.8	-0.4	1.9
Waist Hip Ratio (WHR)	0.1	0.5	1.2	-1.1	-0.0	0.2	-0.7	-0.7
Systolic Blood Pressure	0.8	3.9	17.5	4.2	-0.6	0.8	0.1	1.1
Smoking Status	0.4	0.9	3.4	-0.9	-0.2	0.1	-1.9	0.4
Allergy or Eczema	0.4	1.0	2.0	1.4	1.1	0.4	1.0	0.7
Cardiovascular Disease	1.7	5.5	12.1	3.5	1.3	-0.0	-1.7	3.2
Hypothyroidism (self reported)	0.4	1.0	1.7	0.5	1.3	-1.2	1.1	0.6
Respiratory disease	0.8	1.8	4.1	0.3	0.9	0.5	-1.9	2.0
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.8	0.1	-0.9	-0.9	-0.6	-0.5
Lung FEV1/FVC ratio	0.3	1.7	4.5	0.3	2.1	-0.4	0.9	1.6
Lung FVC	0.1	0.5	1.6	0.9	-0.3	1.3	0.2	-0.4
Neuroticism	0.4	1.0	2.5	-1.6	-1.4	-0.7	-0.1	-0.3
Chronotype (morning person)	1.5	3.5	9.8	-1.8	-1.4	-3.1	0.3	-1.5
Hair Pigment	0.0	0.0	0.1	0.1	0.2	0.0	-0.0	-0.3
Tanning	0.3	3.6	10.2	-0.9	-2.6	0.3	0.7	-3.2
Hand grip strength (left)	0.5	1.4	5.5	2.4	0.8	0.6	0.3	0.4
Number of treatments/medications taken	3.3	5.9	13.5	2.7	1.5	1.0	-2.4	3.7
Average weekly spirits intake	0.1	0.1	0.3	-0.5	0.4	-0.2	-0.4	0.2
Sensitivity / hurt feelings	0.4	0.6	1.2	-0.2	-1.1	1.0	-0.9	-0.5
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.2	-1.1	-0.9	0.7	-0.6	-0.3
Hearing difficulty/problems: Yes	0.8	1.3	3.1	0.1	1.8	0.4	-0.9	1.5
Relative age of first facial hair	0.2	0.3	0.8	-0.5	-0.3	0.3	-0.5	0.9
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.3	-0.2	1.5	-0.8	0.5	1.0
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.6	-1.6	-1.2	-0.5	-0.0	-1.4
Ever had hysterectomy (womb removed)	1.6	1.8	6.5	0.4	-0.7	2.6	0.8	1.1
Systolic blood pressure, automated reading	0.6	1.8	6.7	2.6	-1.2	0.6	0.5	0.4
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	2.3	-0.3	-0.4	0.1	1.5	0.1
Angina	0.9	1.2	2.5	0.4	1.0	1.0	-1.6	1.3
Medication for hormone replacement therapy	0.4	0.5	1.5	-0.7	-0.4	-0.6	1.2	-0.3
Vitamin and mineral supplements	0.1	0.2	0.3	-0.6	-0.2	-0.3	-0.4	0.5
Supplements: Zinc	0.3	0.4	1.1	1.1	0.8	-0.1	-0.1	-0.3
Medication: Co-codamol	0.3	0.4	1.7	1.3	0.3	0.1	-0.2	-0.0
Medication: Metformin	0.4	0.6	1.5	1.2	0.6	-1.0	0.3	0.2
Diabetes (father)	0.4	0.5	1.3	-0.2	0.2	-1.1	0.2	1.1
Diabetes (mother)	0.3	0.4	1.4	0.4	-0.3	0.3	0.6	-1.2
Severe depression (siblings)	0.6	0.7	1.5	-0.3	-1.2	-0.2	0.7	-1.1
Pack years adult smoking proportion	0.6	0.9	2.3	0.8	1.5	-0.5	-1.2	-0.3
Impedance of leg (right)	0.6	3.0	13.6	-1.0	-0.1	3.7	0.2	-0.8
Leg fat-free mass (left)	0.4	2.2	7.8	2.8	0.4	-0.1	-0.0	1.8
Trunk fat percentage	0.3	1.4	3.5	0.4	-0.1	1.9	-1.2	1.3
Hand grip strength (right)	0.8	2.2	6.7	2.6	1.6	0.5	0.9	0.8
Townsend deprivation index at recruitment	0.2	0.3	0.6	0.0	-0.2	0.6	-0.8	0.6
Current tobacco smoking	0.9	1.5	2.9	-0.8	-1.0	-1.6	-1.7	-0.7
Average weekly fortified wine intake	1.2	1.4	3.2	1.4	0.7	1.1	-1.8	-0.5
Maternal smoking around birth	2.0	2.8	6.2	-1.3	-2.5	0.4	-0.4	-2.4
Fed-up feelings	0.4	0.8	1.7	-0.9	-1.0	1.3	-0.5	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	4.2	-1.6	-0.4	2.0	0.7	-0.2
Relative age voice broke	0.5	0.7	3.3	0.0	-0.1	-0.1	-1.8	-0.5
Taking other prescription medications	1.0	1.6	3.8	0.1	1.0	0.3	-1.9	1.7
Age when periods started (menarche)	0.3	0.6	2.0	-0.1	-0.0	-1.1	-0.1	-1.4
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	6.3	-0.1	-2.5	1.9	-0.5	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.9	-1.4	0.3	0.3	-0.3	1.4
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	3.0	-0.7	0.8	0.1	1.7	0.1
Qualifications: CSEs or equivalent	0.7	1.0	1.8	1.1	-1.4	0.4	0.0	-1.2
Serious illness, injury or assault to yourself	2.0	2.4	5.2	1.1	1.5	-0.8	-2.3	1.6
High blood pressure	1.7	4.8	11.9	3.2	0.6	0.7	-1.1	3.5
Hayfever, allergic rhinitis or eczema	0.8	1.8	3.0	1.7	1.4	1.1	0.3	1.6
Multivitamins +/- minerals	0.6	0.7	2.0	0.3	-0.2	-0.1	1.4	-1.2
Stomach or abdominal pain in last month	0.6	0.8	1.8	0.9	-0.2	1.3	0.2	-1.1
Supplements: Glucosamine	1.0	1.2	2.2	0.6	-1.3	-1.5	-0.6	-1.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.4	-0.4	-0.8	0.4	-1.5	-0.6
Medication: Atenolol	0.2	0.3	1.0	-0.1	-0.5	-0.1	0.5	1.0
Medication: Levothyroxine sodium	0.7	1.1	2.7	1.1	1.6	0.3	1.1	0.7
Sitting height	0.2	1.8	4.8	1.3	-1.4	2.2	0.2	0.3
Chronic bronchitis/emphysema (father)	1.8	2.1	4.7	-1.0	-0.6	2.0	-2.2	0.6
High blood pressure (mother)	0.4	0.5	2.2	0.3	-0.2	-1.5	0.4	0.4
Body mass index (BMI)	0.2	0.8	1.5	0.3	-0.4	-1.2	-1.0	1.0
Impedance of leg (left)	0.8	3.7	16.4	-1.0	-0.1	4.0	-0.3	-0.9
Leg predicted mass (left)	0.5	2.4	8.6	2.9	0.4	-0.1	0.0	1.8
Trunk fat mass	0.4	1.7	3.3	1.4	0.1	1.8	-0.9	1.6
Waist circumference	0.4	1.6	4.5	2.1	0.3	0.6	-0.5	1.6
Number of incorrect matches in round	0.7	1.2	3.5	0.1	-1.9	1.6	-0.5	0.1
Past tobacco smoking	0.6	1.2	3.3	1.8	-0.6	-0.7	1.2	-0.5
Alcohol usually taken with meals	2.3	3.7	6.5	2.2	2.1	2.5	0.7	1.5
Nervous feelings	1.0	1.9	6.1	0.1	-1.7	-2.5	0.2	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.9	0.5	0.1	0.4	-0.5	1.0
Hearing difficulty/problems with background noise	2.9	4.6	9.0	-1.9	0.2	2.4	-3.0	2.2
Hair/balding pattern: Pattern 2	0.4	0.5	1.0	-1.0	-0.2	1.0	-0.5	-0.4
Had menopause	0.3	0.4	1.1	1.0	0.4	-0.9	-0.1	-0.1
Had other major operations	1.1	1.3	4.1	0.5	2.0	0.8	0.1	1.2
Forced vital capacity (FVC)	0.7	2.7	7.2	2.1	-0.1	2.7	1.4	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.0	-1.0	-0.2	0.4	0.6	0.5
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.5	0.2	1.3	0.3	-0.7	1.6
Qualifications: None of the above	0.2	0.5	1.7	0.1	-1.3	0.9	0.1	0.2
Financial difficulties in last 2 years	1.3	1.7	4.1	-1.0	-2.0	-0.7	0.1	-1.7
Mouth/teeth dental problems	1.0	1.6	4.2	-0.7	0.2	-0.6	2.1	-1.7
Heart attack	0.3	0.3	0.9	0.4	-0.6	-0.3	1.0	-0.1
Allergy	0.9	2.1	3.6	-1.8	-1.3	-1.2	0.8	-1.9
Pain all over the body in last month	1.5	1.6	6.7	1.0	-0.6	-0.4	-2.6	0.3
Diabetes (self-reported)	0.4	0.5	1.4	1.2	0.1	-0.5	0.9	0.6
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.4	1.2	0.4	1.1	-0.8	1.0
Medication: Ramipril	0.5	0.7	2.0	1.1	-1.4	-0.0	-0.0	0.4
Medication: Simvastatin	0.5	0.7	1.2	1.0	-0.5	-1.1	0.8	0.5
Fluid intelligence score	1.0	2.0	3.3	0.9	1.7	-1.7	1.8	0.3
Illnesses of siblings	0.3	0.5	1.1	-0.5	0.9	-0.1	1.0	0.3
Neuroticism score	0.6	1.2	4.1	-1.1	-2.0	-0.2	-0.3	-0.7
Weight	0.4	2.0	6.1	2.5	0.1	0.8	-0.7	1.6
Impedance of arm (right)	0.3	1.6	6.2	-0.2	1.0	2.5	-0.8	0.4
Arm fat percentage (right)	0.2	0.6	1.6	0.4	-0.0	0.1	-1.2	1.3
Trunk fat-free mass	0.5	2.9	13.2	3.6	-0.0	-0.1	0.0	1.1
Hip circumference	1.0	4.2	11.6	3.4	0.8	1.5	-0.8	2.4
Time employed in main current job	0.8	0.9	2.0	0.7	1.1	0.2	-1.4	0.8
Alcohol intake versus 10 years previously	0.3	0.5	1.3	-0.3	0.7	1.1	0.6	0.3
Father’s age at death	1.5	2.0	6.2	-1.7	-0.8	-0.0	-0.1	-2.5
Worrier / anxious feelings	0.6	1.2	3.0	-1.7	-1.0	-1.3	0.2	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.3	0.1	0.6	0.5	0.5
Falls in the last year	0.2	0.2	0.5	0.3	-0.6	0.2	0.7	-0.2
Hair/balding pattern: Pattern 3	0.4	0.6	1.4	0.8	-0.1	-1.0	1.2	0.1
Number of live births	1.3	1.8	3.9	-2.0	-1.5	-0.4	1.5	-0.5
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	4.1	1.5	0.3	2.0	1.9	0.4
Pulse rate	0.2	0.3	0.6	-0.6	0.7	-0.1	-0.5	0.8
Happiness	0.5	0.6	2.6	-0.7	1.6	-0.2	0.1	0.0
Noisy workplace	0.3	0.3	0.8	0.9	0.1	0.5	0.7	0.4
Qualifications: A levels/AS levels or equivalent	0.4	0.8	3.8	0.1	1.9	0.4	0.2	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.0	1.4	-0.1	0.7	-0.0	0.9
Mouth/teeth dental problems: Dentures	1.1	1.9	7.9	0.2	-1.2	0.3	-2.8	0.5
Asthma	0.6	1.2	2.0	1.2	0.9	0.8	-1.1	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	3.8	-0.7	0.5	0.6	-0.4	2.0
Medication: Cholesterol lowering	1.0	1.6	4.3	1.0	0.5	0.2	-1.5	2.1
Depression (self-reported)	0.1	0.1	0.6	-0.2	0.3	-0.2	0.0	0.8
Medication: Lansoprazole	0.9	1.1	4.0	-0.9	-2.0	-0.2	0.4	0.5
Prospective memory result	0.5	0.6	1.2	1.0	-1.1	0.0	-0.9	0.3
Lung cancer (father)	0.7	0.8	2.5	0.7	-0.9	1.6	-0.3	-0.3
Illnesses of mother	0.7	0.9	1.4	-0.8	1.2	0.9	0.4	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	7.3	1.8	0.5	2.7	0.9	0.9
Pulse wave Arterial Stiffness index	2.4	2.8	8.2	2.0	2.9	0.1	-0.4	1.2
Impedance of arm (left)	0.5	2.3	7.7	-0.1	1.8	2.8	-0.4	0.7
Arm fat mass (right)	0.2	0.9	1.9	1.2	-0.1	-0.0	-1.0	1.4
Trunk predicted mass	0.5	2.8	13.0	3.6	0.0	-0.1	0.0	1.1
Standing height	1.0	10.1	25.3	5.0	1.2	4.6	0.4	1.6
Length of working week for main job	0.4	0.5	1.6	1.3	0.7	0.1	-0.1	-0.5
Exposure to tobacco smoke at home	2.3	2.5	4.9	-2.2	-1.0	-1.4	0.8	-2.1
Breastfed as a baby	0.4	0.4	0.8	0.9	0.9	-0.8	0.0	0.2
Tense / ‘highly strung’	0.9	1.5	6.6	0.4	-2.6	0.8	-0.1	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.2	-0.2	0.5	1.5	-1.8	0.3
Hair/balding pattern: Pattern 4	0.2	0.4	0.7	-0.8	0.6	0.2	-0.6	-0.7
Birth weight of first child	0.1	0.1	0.3	0.2	0.3	0.5	-0.5	0.2
Peak expiratory flow (PEF)	0.6	1.4	4.9	1.0	1.0	2.2	0.5	0.2
Pulse wave reflection index	2.3	2.8	6.2	2.5	2.2	1.4	-0.5	0.8
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.1	-0.1	-0.1	-0.4	-1.4	-0.4
Loud music exposure frequency	0.7	0.8	1.6	1.3	0.7	1.0	-0.7	0.4
Qualifications: O levels/GCSEs or equivalent	2.5	4.0	10.3	2.1	3.2	-2.0	0.1	1.0
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.7	0.5	1.3	0.6	-0.5	1.1
Blood clot in the leg (DVT)	0.6	0.8	2.0	-0.4	1.4	-1.1	-0.5	0.6
Medication: Paracetamol	1.6	2.7	8.7	-1.5	-1.5	3.0	-0.6	-0.2
Headache pain in last month	0.9	1.5	4.8	0.1	0.6	2.2	-1.1	1.0
Medication for cholesterol, blood pressure or diabetes	2.0	3.4	8.3	-2.2	-1.5	-0.6	1.0	-2.9
Glaucoma (self-reported)	1.0	1.2	3.6	-1.0	-0.3	-0.4	-1.9	1.0
Gout (self-reported)	0.0	0.0	0.1	-0.3	0.1	-0.0	-0.3	-0.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.7	0.6	0.9	-0.4	1.3	0.8
Medication: Amlodipine	1.1	1.5	5.7	0.2	-0.3	-0.3	-1.2	2.4
Medication: Ventolin 100micrograms inhaler	0.8	1.1	5.1	0.0	-0.2	0.5	-2.2	0.0
Birth weight	0.2	0.4	1.2	-0.1	-1.1	-0.1	0.1	-0.7
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.9	-0.3	0.0	1.7	0.1	-1.3
High blood pressure (siblings)	0.4	0.5	1.1	1.0	-0.7	0.3	-0.7	0.7
Forced vital capacity (FVC), Best measure	0.9	3.3	10.0	2.4	0.1	3.2	0.6	0.3
Body fat percentage	0.2	0.9	1.8	0.4	-0.2	1.3	-1.0	1.2
Leg fat percentage (right)	0.2	0.6	1.2	-0.2	-1.1	1.0	-0.5	0.6
Arm fat-free mass (right)	0.4	1.8	8.0	2.8	-0.6	0.4	-0.1	0.9
Exposure to tobacco smoke outside home	1.7	2.3	7.9	-1.5	-2.8	-0.1	-0.2	-1.1
Comparative body size at age 10	0.4	1.0	2.5	-1.3	-0.1	-1.6	0.7	0.3
Number of full brothers	1.1	1.3	3.4	-1.2	-1.3	0.3	-1.8	-0.1
Worry too long after embarrassment	1.3	2.1	4.7	-1.3	-2.2	-0.5	-1.9	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.5	0.7	-0.7	0.6	0.1	0.1
Wheeze or whistling in the chest in last year	0.8	1.4	4.8	0.1	-1.4	0.4	-2.2	0.3
Number of children fathered	0.4	0.5	1.2	0.3	-0.6	0.5	-1.1	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.2	-0.3	0.9	-0.3	-1.1	0.9
Age at first live birth	0.4	0.7	1.4	1.1	1.2	-0.2	0.6	-0.7
Pulse wave peak to peak time	2.2	2.6	8.1	-1.8	-2.8	-0.1	0.7	-1.1
Health satisfaction	2.6	3.3	6.9	1.7	2.6	-0.1	-1.3	2.2
Shortness of breath walking on level ground	0.9	1.1	2.6	0.3	-0.7	0.4	-1.6	1.4
Qualifications: College or University degree	1.0	3.0	13.2	1.2	3.6	0.0	0.6	0.3
Eye problems/disorders: None of the above	0.7	0.8	1.9	-1.0	-0.5	-0.0	-0.9	-1.4
Mouth/teeth dental problems: Loose teeth	1.2	1.5	5.0	-0.5	0.4	-1.4	-2.2	-0.2
Emphysema/chronic bronchitis	0.4	0.5	1.5	-0.4	-0.6	-0.1	-0.6	1.2
Medication for pain relief, constipation, heartburn	1.2	2.0	3.6	0.7	0.2	-1.7	1.9	-1.7
Neck or shoulder pain in last month	0.6	0.8	2.7	-0.7	-0.7	0.0	1.6	-0.6
Medication: Blood pressure	2.0	3.6	8.0	2.6	1.5	0.4	-0.9	2.8
Angina (self-reported)	1.2	1.6	2.9	0.4	1.1	1.2	-1.7	1.6
Migraine (self-reported)	0.2	0.3	0.7	-0.8	0.4	0.1	0.0	0.8
Medication: Ibuprofen	1.0	1.2	5.0	-0.1	0.7	0.5	0.3	2.2
Medication: Allopurinol	0.3	0.3	0.9	-0.2	0.9	-0.2	-0.7	0.5
Medication: Omeprazole	0.8	1.0	2.7	-0.5	1.0	0.1	-1.6	0.8
Medication: Seretide 50 evohaler	1.0	1.2	2.9	-0.9	-1.7	0.4	-1.4	0.3
Mean time to correctly identify matches	0.5	1.0	1.7	-1.3	0.9	-0.7	-0.7	1.2
Heart disease (mother)	0.4	0.5	0.7	0.6	-0.8	0.5	-0.8	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.7	0.6	0.4	1.6	-0.1	0.2
Whole body fat mass	0.3	1.4	2.4	1.3	-0.1	1.5	-0.9	1.5
Leg fat mass (right)	0.2	0.8	1.6	1.1	-0.4	1.0	-0.4	1.2
Arm predicted mass (right)	0.3	1.7	7.3	2.7	-0.6	0.0	-0.4	0.7
Pulse rate, automated reading	0.9	3.0	4.4	-2.0	-1.5	-2.1	0.4	-2.0
Alcohol intake frequency.	0.6	1.3	3.1	1.8	-0.6	-0.3	-0.7	1.6
Comparative height size at age 10	1.2	6.7	22.9	4.8	-0.3	3.0	0.1	1.2
Number of full sisters	1.3	1.6	4.2	-2.1	-1.7	-0.2	-0.7	-0.5
Suffer from ‘nerves’	0.4	0.6	0.9	-0.9	-0.5	-0.8	0.9	-0.4
Overall health rating	0.6	1.3	5.4	-0.3	-0.3	-0.4	-2.3	0.9
Chest pain or discomfort	1.1	1.6	4.8	-0.5	-1.5	0.5	-2.2	-0.5
Had major operations	2.2	2.6	4.6	0.2	1.4	2.1	-1.4	2.1
Age at last live birth	0.5	0.8	2.4	0.1	0.8	-0.3	1.6	-0.9
Family relationship satisfaction	0.5	0.6	1.2	-0.8	1.1	-0.1	0.8	0.8
Leg pain on walking	0.6	0.7	1.9	1.1	-1.4	-0.2	-0.6	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.8	0.1	-0.7	-0.2	1.4	-1.7
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.5	-0.6	-1.2	0.4	-0.1	-0.4
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	3.9	0.1	2.0	1.5	1.0	0.6
Medication: Aspirin	1.4	1.8	4.2	1.7	0.2	0.7	-1.3	2.0
Supplements: Vitamin C	0.3	0.3	1.0	0.3	-0.2	-0.0	-1.0	0.8
Knee pain experienced in last month	0.7	1.1	2.6	0.8	0.2	1.2	-1.6	0.9
Hypertension (Self-reported)	1.9	5.4	12.4	3.5	0.6	0.5	-1.2	3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.5	-0.9	-1.6	1.3	-1.1	0.3
Illnesses of father: Heart disease	0.9	1.2	3.8	0.3	0.9	0.5	-1.9	1.1
Illnesses of siblings: Diabetes	0.6	0.8	2.9	-1.7	0.0	-0.7	-0.6	0.5
Smoking status: Previous	1.0	1.5	3.7	-1.9	0.4	1.3	-1.0	0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	5.5	1.7	-0.0	2.4	-0.4	1.2
Whole body fat-free mass	0.5	2.7	11.8	3.4	0.1	-0.1	-0.2	1.4
Leg fat-free mass (right)	0.5	2.4	8.8	3.0	0.5	-0.1	-0.4	1.7
Arm fat percentage (left)	0.1	0.6	1.7	0.4	0.3	0.0	-1.0	1.3
Average weekly red wine intake	0.4	0.6	1.5	1.2	-0.3	1.0	0.8	-0.0
Handedness (chirality/laterality): Left-handed	2.5	3.0	5.6	-2.3	-2.4	0.3	-0.7	-1.8
Mood swings	1.3	2.4	6.7	-0.7	-2.6	0.0	-0.0	-2.1
Loneliness, isolation	0.3	0.4	0.9	-0.9	0.1	0.7	0.8	0.4
Long-standing illness, disability or infirmity	0.5	0.7	1.5	1.1	0.4	-0.8	-0.5	1.2
Ever had bowel cancer screening	0.2	0.2	0.7	0.8	0.6	-0.1	0.4	0.1
Diabetes diagnosed by doctor	0.1	0.2	0.4	0.5	-0.0	0.0	0.6	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.0	-0.3	0.9	0.5	0.2	1.0
Friendships satisfaction	1.1	1.3	4.9	0.8	2.2	-0.6	0.0	0.9
Qualifications: nursing, teaching	0.3	0.4	0.9	0.6	0.4	-0.8	-0.4	-0.9
Commuting to job workplace: Walk	0.4	0.4	1.0	-0.9	0.1	-0.3	1.0	-0.3
Eye problems/disorders: Cataract	0.9	1.0	1.9	1.4	0.7	-0.6	1.3	0.9
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.6	0.0	-0.3	-0.8	0.4	-0.5
Medication for cholesterol	0.6	1.0	2.9	-0.4	1.1	1.7	-0.6	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.5	-0.2	0.7	0.4	0.3	0.1
Back pain experienced in last month	1.1	1.6	3.4	-1.5	-1.1	-1.8	0.4	-1.1
Mineral and other dietary supplements	0.2	0.3	0.6	-0.3	0.7	-0.3	-0.6	0.7
Breast cancer (self-reported)	1.0	1.2	3.0	0.8	1.7	-0.8	1.0	0.7
Asthma (self-reported)	0.7	1.3	2.5	1.3	0.9	0.9	-0.9	1.6
Osteoporosis (self-reported)	0.2	0.2	0.9	0.9	-0.2	0.4	-0.4	-0.0
Osteoarthritis (self-reported)	1.4	1.8	3.8	2.0	-0.4	1.5	-1.4	0.9
Medication: Aspirin	1.2	1.6	3.7	1.8	0.2	-0.0	-0.9	1.9
Medication: Gliclazide	1.7	1.9	4.2	-0.9	-1.2	-0.5	1.8	-2.0
Illnesses of father: None of the above (group 1)	1.0	1.2	3.2	-0.6	0.2	-0.9	1.8	-1.2
Smoking status: Current	0.9	1.4	3.4	-0.5	-0.8	-1.8	-1.2	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.3	-0.7	-0.4	1.5	0.0	0.7
Whole body water mass	0.5	2.6	11.2	3.3	0.0	-0.1	-0.2	1.3
Leg predicted mass (right)	0.5	2.6	9.2	3.0	0.6	-0.1	-0.3	1.8
Arm fat mass (left)	0.2	0.7	1.3	1.0	-0.2	-0.1	-1.0	1.1
Number of self-reported non-cancer illnesses	1.8	3.2	7.2	1.2	0.9	1.4	-2.1	2.7
Average weekly champagne plus white wine intake	0.7	1.0	3.0	-0.5	0.7	-1.7	0.9	-0.6
Miserableness	1.5	2.7	6.4	-1.9	-1.6	2.5	0.4	-0.6
Guilty feelings	1.1	1.7	5.0	-2.2	-1.4	-1.0	-0.7	-0.5
Wears glasses or contact lenses	0.1	0.1	0.4	0.6	0.1	-0.1	-0.1	-0.2
Ever taken oral contraceptive pill	0.7	0.8	2.7	-1.6	0.5	-0.0	-0.2	0.9
Hearing aid user	3.7	4.2	8.1	-2.3	-1.8	-2.9	-0.4	-2.1
Mother’s age at death	0.5	0.6	1.1	-1.0	-0.4	-0.8	-0.7	-1.0
Financial situation satisfaction	0.8	0.9	2.3	-1.5	-0.8	-1.0	0.0	-0.9
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.6	-1.3	-0.3	0.0	-0.7	-0.5
Commuting to job workplace: Public transport	0.5	0.6	2.1	1.5	0.1	-0.6	0.1	-0.9
Eye problems/disorders: Glaucoma	0.7	0.9	1.4	-0.7	-0.3	-1.1	-1.2	1.0
Medication: Blood pressure	0.8	1.5	2.9	1.7	-0.8	-1.6	-1.1	0.0
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.9	0.6	0.2	0.6	0.9	1.0
Supplements: Fish oil (including cod liver oil)	1.4	1.9	4.4	2.1	1.3	0.9	0.7	1.4
High cholesterol (Self-reported)	0.2	0.3	0.6	-0.7	-0.6	0.2	0.0	0.6
Medication: Bendroflumethiazide	3.2	4.8	11.5	3.4	1.4	1.1	-0.2	3.0
Medication: Paracetamol	1.1	1.7	7.0	0.6	-0.2	2.7	-0.8	0.6
Medication: Lisinopril	0.6	0.8	2.0	1.3	-0.3	1.4	-0.2	0.2
Medication: Atorvastatin	0.8	1.0	3.2	0.7	1.0	-0.5	-1.8	0.2
Illnesses of father: High blood pressure	0.3	0.4	0.9	0.9	-0.5	-0.2	-0.9	-0.4
Alcohol drinker status: Never	0.8	1.0	4.7	-0.1	-2.2	-0.1	-0.0	-0.4
Ever smoked	0.6	1.0	2.4	-1.3	1.6	0.1	-0.9	-0.2
Basal metabolic rate	0.5	2.5	10.4	3.2	0.1	0.1	-0.4	1.5
Leg fat percentage (left)	0.2	0.6	1.1	-0.3	-1.0	0.9	-0.9	0.5
Arm fat-free mass (left)	0.4	1.9	8.0	2.8	-0.8	0.0	-0.5	0.6
Number of operations (self-reported)	2.7	4.0	7.6	1.5	1.7	2.8	-1.9	1.9
Average weekly beer plus cider intake	5.5	7.9	20.1	-4.5	-2.2	-1.6	0.6	-3.4
Irritability	0.3	0.5	1.8	0.4	-0.2	0.2	-1.3	0.6
Risk taking	0.1	0.1	0.3	-0.5	0.4	-0.0	0.1	-0.5
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.4	1.1	1.5	0.9	0.3	0.2
Fractured/broken bones in last 5 years	2.0	2.5	4.9	0.2	1.5	2.2	-1.2	2.0
Age started oral contraceptive pill	0.6	0.7	3.2	0.0	-0.4	-0.5	-1.8	0.2
Diastolic blood pressure, automated reading	0.7	2.2	9.1	3.0	-0.5	-0.4	1.0	0.5
Ever depressed for a whole week	2.3	2.8	3.4	1.4	1.8	1.8	-1.7	1.6
Unable to work because of sickness or disability	1.0	1.2	2.8	1.2	0.1	1.7	0.3	1.3
Commuting to job workplace: Cycle	2.4	2.9	7.7	1.3	2.8	0.3	-2.0	1.2
Myopia	0.9	1.4	2.6	1.6	1.0	1.5	0.5	-1.0
Vascular/heart problems diagnosed by doctor	1.8	5.0	12.2	-3.2	-0.7	-0.3	1.4	-3.5
Cholesterol lowering medication	1.2	1.7	3.0	0.2	-1.3	-1.3	1.4	-1.7
Medication: Omeprazole (e.g. Zanprol)	0.5	0.5	1.7	-0.4	0.5	0.2	-1.3	0.8
Pain experienced in last month	0.1	0.1	0.3	-0.2	0.4	-0.2	0.5	0.4
Supplements: Calcium	0.8	0.9	1.8	-0.9	-0.9	1.4	-0.7	-0.6
Basal cell carcinoma (self-reported)	0.6	0.7	1.6	-0.7	0.0	-1.2	0.9	-0.9
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.8	0.3	-0.7	-0.3	1.3	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.3	-0.5	1.1	-0.9	-0.4	0.6
Heart disease (siblings)	0.8	1.0	2.3	0.4	-1.3	0.2	-0.9	-1.5
Alcohol drinker status: Previous	1.3	1.5	2.9	0.6	-1.0	0.9	-1.7	1.6
Pack years of smoking	0.6	1.0	2.0	1.0	1.4	-0.3	-1.3	-0.2
Impedance of whole body	0.5	2.6	11.5	-0.9	0.6	3.4	-0.3	-0.4
Leg fat mass (left)	0.2	0.8	1.5	0.9	-0.3	1.0	-0.6	1.2
Arm predicted mass (left)	0.4	1.8	7.8	2.8	-1.0	-0.2	-0.4	0.3