Hub : Genes

CCDC112

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0380 0.0180 6.5e-03 0.002 0.008 0.002 0.007 0.005 1.8e-01 3.5e-02 1.9e-01 0.0380 8.1e-02
2 METSIM Adipose 0.0338 0.0186 2.3e-02 0.008 0.014 0.006 0.014 0.008 2.0e-02 2.6e-03 3.1e-02 0.0025 1.7e-02
3 YFS Blood 0.0189 0.0107 1.1e-02 0.002 0.002 -0.001 0.003 0.000 4.6e-02 4.3e-02 9.0e-01 0.0280 2.4e-01
4 TCGA Brain Lower Grade Glioma 0.1012 0.0464 3.4e-03 0.010 0.020 0.031 NA 0.007 2.4e-02 2.1e-03 1.7e-04 NA 4.2e-02
5 TCGA Thyroid Carcinoma 0.1330 0.0410 1.0e-13 0.094 0.136 0.110 NA 0.138 1.9e-09 3.7e-13 8.3e-11 NA 2.3e-13

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.6 2.5 4.9 1.6 1.9 1.0 -0.5 2.2
Bipolar Disorder or Schizophrenia 1.5 3.6 5.8 2.4 2.2 2.0 0.4 1.8
Depressed Affect (Nagel 2018) 1.2 2.4 5.0 -1.8 -2.2 1.0 -0.7 -1.5
Depression (Nagel 2018) 0.7 1.1 2.0 -1.2 -1.2 1.4 0.7 -0.5
Intelligence (Savage-Jansen 2018) 1.0 3.1 10.1 1.4 3.2 -1.1 0.6 1.4
Neuroticism (Nagel 2018) 1.1 2.7 7.5 -1.9 -2.7 0.2 -0.9 -1.2
Schizophrenia (2018) 0.8 1.8 3.3 1.8 1.3 1.7 0.9 0.5
Schizophrenia vs Biploar Disorder 0.2 0.3 0.8 0.2 -0.9 0.2 0.7 -0.5
Worry (Nagel 2018) 0.6 1.2 2.9 -0.7 -1.7 -0.9 1.2 -0.7
Alzheimer’s Disease (in mother) 0.8 1.0 1.3 -1.0 -1.1 1.1 -1.1 -0.2
Alzheimer’s Disease (in father) 1.8 2.0 6.9 1.2 0.6 -0.8 2.6 0.7
Alzheimer’s Disease (including proxy) 0.7 1.1 2.7 -1.3 -1.6 0.7 0.7 -0.2
Crohns Disease (2017) 0.7 1.6 3.2 -1.1 -1.8 -1.3 -0.9 -1.1
Irritable Bowel Disease (IBD) 1.3 3.1 8.8 -0.7 -3.0 -1.2 -0.4 -2.2
Ulcerative Colitis (UC) 0.9 1.8 4.7 0.8 -2.2 -0.3 -0.2 -1.9
Major Depression (MDD) 2.1 2.5 5.7 1.8 2.4 1.0 0.3 1.5
Reaction Time 0.4 0.8 2.5 -1.6 0.3 -1.0 -0.3 0.5
Verbal and Numeric Reasoning (VNR) 1.3 3.0 9.4 1.4 3.1 -1.4 0.9 1.0
Breast Cancer 0.3 0.8 2.7 -0.2 -0.9 1.6 -0.0 0.5
Ovarian Cancer 0.9 1.2 2.7 -0.9 -0.6 -0.8 -1.6 -1.3
Prostate Cancer 0.6 0.8 1.7 1.3 1.0 0.1 -0.2 1.1
Age at First Birth 0.3 0.4 1.0 -0.5 0.2 0.4 0.9 -1.0
Bipolar Disorder (2011) 2.4 2.4 5.2 1.9 2.3 0.4 -0.7 1.5
Body Mass Index (BMI) (2010) 0.3 0.4 1.0 -1.0 0.0 -0.2 -0.9 -0.1
Coronary Artery Disease (CAD) 0.2 0.3 1.1 0.3 0.2 -1.1 0.4 0.3
Crohns Disease (2012) 1.3 2.1 6.6 -1.4 -0.9 -0.9 -2.6 -0.7
Mean Putamen Volume 0.9 1.0 3.5 0.5 0.4 -1.9 -1.1 0.3
Fasting Glucose 2.2 2.7 8.3 -2.9 -1.3 0.1 0.6 -1.7
HbA1C 0.7 0.8 2.4 -0.4 0.7 -1.5 0.1 -1.0
HDL Cholesterol 0.1 0.2 0.8 -0.4 -0.1 0.0 0.9 -0.4
LDL Cholesterol 0.5 0.7 1.1 0.9 1.0 0.9 -1.0 -0.0
Lupus 0.2 0.4 0.8 0.6 -0.8 0.9 -0.3 0.1
Neuroticism (2016) 0.4 0.5 1.1 -1.0 -1.1 0.5 -0.5 -0.1
Primary Biliary Cirrhosis 0.7 1.1 1.9 -0.5 -1.3 -0.6 1.4 -1.1
Rheumatoid Arthritis 1.3 1.8 2.8 0.8 1.7 1.5 0.8 1.7
Schizophrenia (2014) 1.0 2.2 5.1 2.2 0.9 2.0 0.2 1.0
Triglycerides 0.3 0.5 1.4 -0.8 0.5 0.3 -1.2 0.6
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.7 -0.3 0.6 -0.9 0.3 -0.2
Ulcerative Colitis 0.6 0.9 3.0 0.7 -1.7 0.1 0.7 -0.6
Blood Eosinophil Count 0.3 2.6 6.9 0.1 0.4 1.7 -1.7 2.6
Blood Platelet Count 0.2 2.3 5.1 -1.6 -1.8 2.2 -0.3 -0.8
Blood Red Count 0.1 1.1 3.0 -1.7 -0.0 1.1 -0.3 1.0
Blood White Count 0.6 4.2 12.1 -0.4 -0.1 3.5 -2.9 0.5
Heel T-Score 0.1 1.1 2.9 -0.6 -1.7 0.2 1.3 0.9
BMI 0.1 0.9 1.2 1.1 0.4 -0.9 -0.9 1.1
Height 1.0 20.2 61.5 6.0 0.6 7.8 -0.4 1.9
Waist Hip Ratio (WHR) 0.1 0.5 1.2 -1.1 -0.0 0.2 -0.7 -0.7
Systolic Blood Pressure 0.8 3.9 17.5 4.2 -0.6 0.8 0.1 1.1
Smoking Status 0.4 0.9 3.4 -0.9 -0.2 0.1 -1.9 0.4
Allergy or Eczema 0.4 1.0 2.0 1.4 1.1 0.4 1.0 0.7
Cardiovascular Disease 1.7 5.5 12.1 3.5 1.3 -0.0 -1.7 3.2
Hypothyroidism (self reported) 0.4 1.0 1.7 0.5 1.3 -1.2 1.1 0.6
Respiratory disease 0.8 1.8 4.1 0.3 0.9 0.5 -1.9 2.0
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.8 0.1 -0.9 -0.9 -0.6 -0.5
Lung FEV1/FVC ratio 0.3 1.7 4.5 0.3 2.1 -0.4 0.9 1.6
Lung FVC 0.1 0.5 1.6 0.9 -0.3 1.3 0.2 -0.4
Neuroticism 0.4 1.0 2.5 -1.6 -1.4 -0.7 -0.1 -0.3
Chronotype (morning person) 1.5 3.5 9.8 -1.8 -1.4 -3.1 0.3 -1.5
Hair Pigment 0.0 0.0 0.1 0.1 0.2 0.0 -0.0 -0.3
Tanning 0.3 3.6 10.2 -0.9 -2.6 0.3 0.7 -3.2
Hand grip strength (left) 0.5 1.4 5.5 2.4 0.8 0.6 0.3 0.4
Number of treatments/medications taken 3.3 5.9 13.5 2.7 1.5 1.0 -2.4 3.7
Average weekly spirits intake 0.1 0.1 0.3 -0.5 0.4 -0.2 -0.4 0.2
Sensitivity / hurt feelings 0.4 0.6 1.2 -0.2 -1.1 1.0 -0.9 -0.5
Frequency of depressed mood in last 2 weeks 0.4 0.6 1.2 -1.1 -0.9 0.7 -0.6 -0.3
Hearing difficulty/problems: Yes 0.8 1.3 3.1 0.1 1.8 0.4 -0.9 1.5
Relative age of first facial hair 0.2 0.3 0.8 -0.5 -0.3 0.3 -0.5 0.9
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 2.3 -0.2 1.5 -0.8 0.5 1.0
Ever used hormone-replacement therapy (HRT) 1.0 1.3 2.6 -1.6 -1.2 -0.5 -0.0 -1.4
Ever had hysterectomy (womb removed) 1.6 1.8 6.5 0.4 -0.7 2.6 0.8 1.1
Systolic blood pressure, automated reading 0.6 1.8 6.7 2.6 -1.2 0.6 0.5 0.4
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 2.3 -0.3 -0.4 0.1 1.5 0.1
Angina 0.9 1.2 2.5 0.4 1.0 1.0 -1.6 1.3
Medication for hormone replacement therapy 0.4 0.5 1.5 -0.7 -0.4 -0.6 1.2 -0.3
Vitamin and mineral supplements 0.1 0.2 0.3 -0.6 -0.2 -0.3 -0.4 0.5
Supplements: Zinc 0.3 0.4 1.1 1.1 0.8 -0.1 -0.1 -0.3
Medication: Co-codamol 0.3 0.4 1.7 1.3 0.3 0.1 -0.2 -0.0
Medication: Metformin 0.4 0.6 1.5 1.2 0.6 -1.0 0.3 0.2
Diabetes (father) 0.4 0.5 1.3 -0.2 0.2 -1.1 0.2 1.1
Diabetes (mother) 0.3 0.4 1.4 0.4 -0.3 0.3 0.6 -1.2
Severe depression (siblings) 0.6 0.7 1.5 -0.3 -1.2 -0.2 0.7 -1.1
Pack years adult smoking proportion 0.6 0.9 2.3 0.8 1.5 -0.5 -1.2 -0.3
Impedance of leg (right) 0.6 3.0 13.6 -1.0 -0.1 3.7 0.2 -0.8
Leg fat-free mass (left) 0.4 2.2 7.8 2.8 0.4 -0.1 -0.0 1.8
Trunk fat percentage 0.3 1.4 3.5 0.4 -0.1 1.9 -1.2 1.3
Hand grip strength (right) 0.8 2.2 6.7 2.6 1.6 0.5 0.9 0.8
Townsend deprivation index at recruitment 0.2 0.3 0.6 0.0 -0.2 0.6 -0.8 0.6
Current tobacco smoking 0.9 1.5 2.9 -0.8 -1.0 -1.6 -1.7 -0.7
Average weekly fortified wine intake 1.2 1.4 3.2 1.4 0.7 1.1 -1.8 -0.5
Maternal smoking around birth 2.0 2.8 6.2 -1.3 -2.5 0.4 -0.4 -2.4
Fed-up feelings 0.4 0.8 1.7 -0.9 -1.0 1.3 -0.5 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.5 4.2 -1.6 -0.4 2.0 0.7 -0.2
Relative age voice broke 0.5 0.7 3.3 0.0 -0.1 -0.1 -1.8 -0.5
Taking other prescription medications 1.0 1.6 3.8 0.1 1.0 0.3 -1.9 1.7
Age when periods started (menarche) 0.3 0.6 2.0 -0.1 -0.0 -1.1 -0.1 -1.4
Bilateral oophorectomy (both ovaries removed) 2.0 2.3 6.3 -0.1 -2.5 1.9 -0.5 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 1.9 -1.4 0.3 0.3 -0.3 1.4
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 3.0 -0.7 0.8 0.1 1.7 0.1
Qualifications: CSEs or equivalent 0.7 1.0 1.8 1.1 -1.4 0.4 0.0 -1.2
Serious illness, injury or assault to yourself 2.0 2.4 5.2 1.1 1.5 -0.8 -2.3 1.6
High blood pressure 1.7 4.8 11.9 3.2 0.6 0.7 -1.1 3.5
Hayfever, allergic rhinitis or eczema 0.8 1.8 3.0 1.7 1.4 1.1 0.3 1.6
Multivitamins +/- minerals 0.6 0.7 2.0 0.3 -0.2 -0.1 1.4 -1.2
Stomach or abdominal pain in last month 0.6 0.8 1.8 0.9 -0.2 1.3 0.2 -1.1
Supplements: Glucosamine 1.0 1.2 2.2 0.6 -1.3 -1.5 -0.6 -1.2
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 2.4 -0.4 -0.8 0.4 -1.5 -0.6
Medication: Atenolol 0.2 0.3 1.0 -0.1 -0.5 -0.1 0.5 1.0
Medication: Levothyroxine sodium 0.7 1.1 2.7 1.1 1.6 0.3 1.1 0.7
Sitting height 0.2 1.8 4.8 1.3 -1.4 2.2 0.2 0.3
Chronic bronchitis/emphysema (father) 1.8 2.1 4.7 -1.0 -0.6 2.0 -2.2 0.6
High blood pressure (mother) 0.4 0.5 2.2 0.3 -0.2 -1.5 0.4 0.4
Body mass index (BMI) 0.2 0.8 1.5 0.3 -0.4 -1.2 -1.0 1.0
Impedance of leg (left) 0.8 3.7 16.4 -1.0 -0.1 4.0 -0.3 -0.9
Leg predicted mass (left) 0.5 2.4 8.6 2.9 0.4 -0.1 0.0 1.8
Trunk fat mass 0.4 1.7 3.3 1.4 0.1 1.8 -0.9 1.6
Waist circumference 0.4 1.6 4.5 2.1 0.3 0.6 -0.5 1.6
Number of incorrect matches in round 0.7 1.2 3.5 0.1 -1.9 1.6 -0.5 0.1
Past tobacco smoking 0.6 1.2 3.3 1.8 -0.6 -0.7 1.2 -0.5
Alcohol usually taken with meals 2.3 3.7 6.5 2.2 2.1 2.5 0.7 1.5
Nervous feelings 1.0 1.9 6.1 0.1 -1.7 -2.5 0.2 -0.8
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.9 0.5 0.1 0.4 -0.5 1.0
Hearing difficulty/problems with background noise 2.9 4.6 9.0 -1.9 0.2 2.4 -3.0 2.2
Hair/balding pattern: Pattern 2 0.4 0.5 1.0 -1.0 -0.2 1.0 -0.5 -0.4
Had menopause 0.3 0.4 1.1 1.0 0.4 -0.9 -0.1 -0.1
Had other major operations 1.1 1.3 4.1 0.5 2.0 0.8 0.1 1.2
Forced vital capacity (FVC) 0.7 2.7 7.2 2.1 -0.1 2.7 1.4 0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 1.0 -1.0 -0.2 0.4 0.6 0.5
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 2.5 0.2 1.3 0.3 -0.7 1.6
Qualifications: None of the above 0.2 0.5 1.7 0.1 -1.3 0.9 0.1 0.2
Financial difficulties in last 2 years 1.3 1.7 4.1 -1.0 -2.0 -0.7 0.1 -1.7
Mouth/teeth dental problems 1.0 1.6 4.2 -0.7 0.2 -0.6 2.1 -1.7
Heart attack 0.3 0.3 0.9 0.4 -0.6 -0.3 1.0 -0.1
Allergy 0.9 2.1 3.6 -1.8 -1.3 -1.2 0.8 -1.9
Pain all over the body in last month 1.5 1.6 6.7 1.0 -0.6 -0.4 -2.6 0.3
Diabetes (self-reported) 0.4 0.5 1.4 1.2 0.1 -0.5 0.9 0.6
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 1.4 1.2 0.4 1.1 -0.8 1.0
Medication: Ramipril 0.5 0.7 2.0 1.1 -1.4 -0.0 -0.0 0.4
Medication: Simvastatin 0.5 0.7 1.2 1.0 -0.5 -1.1 0.8 0.5
Fluid intelligence score 1.0 2.0 3.3 0.9 1.7 -1.7 1.8 0.3
Illnesses of siblings 0.3 0.5 1.1 -0.5 0.9 -0.1 1.0 0.3
Neuroticism score 0.6 1.2 4.1 -1.1 -2.0 -0.2 -0.3 -0.7
Weight 0.4 2.0 6.1 2.5 0.1 0.8 -0.7 1.6
Impedance of arm (right) 0.3 1.6 6.2 -0.2 1.0 2.5 -0.8 0.4
Arm fat percentage (right) 0.2 0.6 1.6 0.4 -0.0 0.1 -1.2 1.3
Trunk fat-free mass 0.5 2.9 13.2 3.6 -0.0 -0.1 0.0 1.1
Hip circumference 1.0 4.2 11.6 3.4 0.8 1.5 -0.8 2.4
Time employed in main current job 0.8 0.9 2.0 0.7 1.1 0.2 -1.4 0.8
Alcohol intake versus 10 years previously 0.3 0.5 1.3 -0.3 0.7 1.1 0.6 0.3
Father’s age at death 1.5 2.0 6.2 -1.7 -0.8 -0.0 -0.1 -2.5
Worrier / anxious feelings 0.6 1.2 3.0 -1.7 -1.0 -1.3 0.2 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.4 -0.3 0.1 0.6 0.5 0.5
Falls in the last year 0.2 0.2 0.5 0.3 -0.6 0.2 0.7 -0.2
Hair/balding pattern: Pattern 3 0.4 0.6 1.4 0.8 -0.1 -1.0 1.2 0.1
Number of live births 1.3 1.8 3.9 -2.0 -1.5 -0.4 1.5 -0.5
Forced expiratory volume in 1-second (FEV1) 0.6 2.0 4.1 1.5 0.3 2.0 1.9 0.4
Pulse rate 0.2 0.3 0.6 -0.6 0.7 -0.1 -0.5 0.8
Happiness 0.5 0.6 2.6 -0.7 1.6 -0.2 0.1 0.0
Noisy workplace 0.3 0.3 0.8 0.9 0.1 0.5 0.7 0.4
Qualifications: A levels/AS levels or equivalent 0.4 0.8 3.8 0.1 1.9 0.4 0.2 -0.4
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.0 1.4 -0.1 0.7 -0.0 0.9
Mouth/teeth dental problems: Dentures 1.1 1.9 7.9 0.2 -1.2 0.3 -2.8 0.5
Asthma 0.6 1.2 2.0 1.2 0.9 0.8 -1.1 1.4
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 3.8 -0.7 0.5 0.6 -0.4 2.0
Medication: Cholesterol lowering 1.0 1.6 4.3 1.0 0.5 0.2 -1.5 2.1
Depression (self-reported) 0.1 0.1 0.6 -0.2 0.3 -0.2 0.0 0.8
Medication: Lansoprazole 0.9 1.1 4.0 -0.9 -2.0 -0.2 0.4 0.5
Prospective memory result 0.5 0.6 1.2 1.0 -1.1 0.0 -0.9 0.3
Lung cancer (father) 0.7 0.8 2.5 0.7 -0.9 1.6 -0.3 -0.3
Illnesses of mother 0.7 0.9 1.4 -0.8 1.2 0.9 0.4 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.5 7.3 1.8 0.5 2.7 0.9 0.9
Pulse wave Arterial Stiffness index 2.4 2.8 8.2 2.0 2.9 0.1 -0.4 1.2
Impedance of arm (left) 0.5 2.3 7.7 -0.1 1.8 2.8 -0.4 0.7
Arm fat mass (right) 0.2 0.9 1.9 1.2 -0.1 -0.0 -1.0 1.4
Trunk predicted mass 0.5 2.8 13.0 3.6 0.0 -0.1 0.0 1.1
Standing height 1.0 10.1 25.3 5.0 1.2 4.6 0.4 1.6
Length of working week for main job 0.4 0.5 1.6 1.3 0.7 0.1 -0.1 -0.5
Exposure to tobacco smoke at home 2.3 2.5 4.9 -2.2 -1.0 -1.4 0.8 -2.1
Breastfed as a baby 0.4 0.4 0.8 0.9 0.9 -0.8 0.0 0.2
Tense / ‘highly strung’ 0.9 1.5 6.6 0.4 -2.6 0.8 -0.1 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 3.2 -0.2 0.5 1.5 -1.8 0.3
Hair/balding pattern: Pattern 4 0.2 0.4 0.7 -0.8 0.6 0.2 -0.6 -0.7
Birth weight of first child 0.1 0.1 0.3 0.2 0.3 0.5 -0.5 0.2
Peak expiratory flow (PEF) 0.6 1.4 4.9 1.0 1.0 2.2 0.5 0.2
Pulse wave reflection index 2.3 2.8 6.2 2.5 2.2 1.4 -0.5 0.8
Ever highly irritable/argumentative for 2 days 0.4 0.5 2.1 -0.1 -0.1 -0.4 -1.4 -0.4
Loud music exposure frequency 0.7 0.8 1.6 1.3 0.7 1.0 -0.7 0.4
Qualifications: O levels/GCSEs or equivalent 2.5 4.0 10.3 2.1 3.2 -2.0 0.1 1.0
Mouth/teeth dental problems: Bleeding gums 0.6 0.7 1.7 0.5 1.3 0.6 -0.5 1.1
Blood clot in the leg (DVT) 0.6 0.8 2.0 -0.4 1.4 -1.1 -0.5 0.6
Medication: Paracetamol 1.6 2.7 8.7 -1.5 -1.5 3.0 -0.6 -0.2
Headache pain in last month 0.9 1.5 4.8 0.1 0.6 2.2 -1.1 1.0
Medication for cholesterol, blood pressure or diabetes 2.0 3.4 8.3 -2.2 -1.5 -0.6 1.0 -2.9
Glaucoma (self-reported) 1.0 1.2 3.6 -1.0 -0.3 -0.4 -1.9 1.0
Gout (self-reported) 0.0 0.0 0.1 -0.3 0.1 -0.0 -0.3 -0.2
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 1.7 0.6 0.9 -0.4 1.3 0.8
Medication: Amlodipine 1.1 1.5 5.7 0.2 -0.3 -0.3 -1.2 2.4
Medication: Ventolin 100micrograms inhaler 0.8 1.1 5.1 0.0 -0.2 0.5 -2.2 0.0
Birth weight 0.2 0.4 1.2 -0.1 -1.1 -0.1 0.1 -0.7
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.9 -0.3 0.0 1.7 0.1 -1.3
High blood pressure (siblings) 0.4 0.5 1.1 1.0 -0.7 0.3 -0.7 0.7
Forced vital capacity (FVC), Best measure 0.9 3.3 10.0 2.4 0.1 3.2 0.6 0.3
Body fat percentage 0.2 0.9 1.8 0.4 -0.2 1.3 -1.0 1.2
Leg fat percentage (right) 0.2 0.6 1.2 -0.2 -1.1 1.0 -0.5 0.6
Arm fat-free mass (right) 0.4 1.8 8.0 2.8 -0.6 0.4 -0.1 0.9
Exposure to tobacco smoke outside home 1.7 2.3 7.9 -1.5 -2.8 -0.1 -0.2 -1.1
Comparative body size at age 10 0.4 1.0 2.5 -1.3 -0.1 -1.6 0.7 0.3
Number of full brothers 1.1 1.3 3.4 -1.2 -1.3 0.3 -1.8 -0.1
Worry too long after embarrassment 1.3 2.1 4.7 -1.3 -2.2 -0.5 -1.9 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.5 0.7 -0.7 0.6 0.1 0.1
Wheeze or whistling in the chest in last year 0.8 1.4 4.8 0.1 -1.4 0.4 -2.2 0.3
Number of children fathered 0.4 0.5 1.2 0.3 -0.6 0.5 -1.1 0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.2 -0.3 0.9 -0.3 -1.1 0.9
Age at first live birth 0.4 0.7 1.4 1.1 1.2 -0.2 0.6 -0.7
Pulse wave peak to peak time 2.2 2.6 8.1 -1.8 -2.8 -0.1 0.7 -1.1
Health satisfaction 2.6 3.3 6.9 1.7 2.6 -0.1 -1.3 2.2
Shortness of breath walking on level ground 0.9 1.1 2.6 0.3 -0.7 0.4 -1.6 1.4
Qualifications: College or University degree 1.0 3.0 13.2 1.2 3.6 0.0 0.6 0.3
Eye problems/disorders: None of the above 0.7 0.8 1.9 -1.0 -0.5 -0.0 -0.9 -1.4
Mouth/teeth dental problems: Loose teeth 1.2 1.5 5.0 -0.5 0.4 -1.4 -2.2 -0.2
Emphysema/chronic bronchitis 0.4 0.5 1.5 -0.4 -0.6 -0.1 -0.6 1.2
Medication for pain relief, constipation, heartburn 1.2 2.0 3.6 0.7 0.2 -1.7 1.9 -1.7
Neck or shoulder pain in last month 0.6 0.8 2.7 -0.7 -0.7 0.0 1.6 -0.6
Medication: Blood pressure 2.0 3.6 8.0 2.6 1.5 0.4 -0.9 2.8
Angina (self-reported) 1.2 1.6 2.9 0.4 1.1 1.2 -1.7 1.6
Migraine (self-reported) 0.2 0.3 0.7 -0.8 0.4 0.1 0.0 0.8
Medication: Ibuprofen 1.0 1.2 5.0 -0.1 0.7 0.5 0.3 2.2
Medication: Allopurinol 0.3 0.3 0.9 -0.2 0.9 -0.2 -0.7 0.5
Medication: Omeprazole 0.8 1.0 2.7 -0.5 1.0 0.1 -1.6 0.8
Medication: Seretide 50 evohaler 1.0 1.2 2.9 -0.9 -1.7 0.4 -1.4 0.3
Mean time to correctly identify matches 0.5 1.0 1.7 -1.3 0.9 -0.7 -0.7 1.2
Heart disease (mother) 0.4 0.5 0.7 0.6 -0.8 0.5 -0.8 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 2.7 0.6 0.4 1.6 -0.1 0.2
Whole body fat mass 0.3 1.4 2.4 1.3 -0.1 1.5 -0.9 1.5
Leg fat mass (right) 0.2 0.8 1.6 1.1 -0.4 1.0 -0.4 1.2
Arm predicted mass (right) 0.3 1.7 7.3 2.7 -0.6 0.0 -0.4 0.7
Pulse rate, automated reading 0.9 3.0 4.4 -2.0 -1.5 -2.1 0.4 -2.0
Alcohol intake frequency. 0.6 1.3 3.1 1.8 -0.6 -0.3 -0.7 1.6
Comparative height size at age 10 1.2 6.7 22.9 4.8 -0.3 3.0 0.1 1.2
Number of full sisters 1.3 1.6 4.2 -2.1 -1.7 -0.2 -0.7 -0.5
Suffer from ‘nerves’ 0.4 0.6 0.9 -0.9 -0.5 -0.8 0.9 -0.4
Overall health rating 0.6 1.3 5.4 -0.3 -0.3 -0.4 -2.3 0.9
Chest pain or discomfort 1.1 1.6 4.8 -0.5 -1.5 0.5 -2.2 -0.5
Had major operations 2.2 2.6 4.6 0.2 1.4 2.1 -1.4 2.1
Age at last live birth 0.5 0.8 2.4 0.1 0.8 -0.3 1.6 -0.9
Family relationship satisfaction 0.5 0.6 1.2 -0.8 1.1 -0.1 0.8 0.8
Leg pain on walking 0.6 0.7 1.9 1.1 -1.4 -0.2 -0.6 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 2.8 0.1 -0.7 -0.2 1.4 -1.7
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.5 -0.6 -1.2 0.4 -0.1 -0.4
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 3.9 0.1 2.0 1.5 1.0 0.6
Medication: Aspirin 1.4 1.8 4.2 1.7 0.2 0.7 -1.3 2.0
Supplements: Vitamin C 0.3 0.3 1.0 0.3 -0.2 -0.0 -1.0 0.8
Knee pain experienced in last month 0.7 1.1 2.6 0.8 0.2 1.2 -1.6 0.9
Hypertension (Self-reported) 1.9 5.4 12.4 3.5 0.6 0.5 -1.2 3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 2.5 -0.9 -1.6 1.3 -1.1 0.3
Illnesses of father: Heart disease 0.9 1.2 3.8 0.3 0.9 0.5 -1.9 1.1
Illnesses of siblings: Diabetes 0.6 0.8 2.9 -1.7 0.0 -0.7 -0.6 0.5
Smoking status: Previous 1.0 1.5 3.7 -1.9 0.4 1.3 -1.0 0.9
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.0 5.5 1.7 -0.0 2.4 -0.4 1.2
Whole body fat-free mass 0.5 2.7 11.8 3.4 0.1 -0.1 -0.2 1.4
Leg fat-free mass (right) 0.5 2.4 8.8 3.0 0.5 -0.1 -0.4 1.7
Arm fat percentage (left) 0.1 0.6 1.7 0.4 0.3 0.0 -1.0 1.3
Average weekly red wine intake 0.4 0.6 1.5 1.2 -0.3 1.0 0.8 -0.0
Handedness (chirality/laterality): Left-handed 2.5 3.0 5.6 -2.3 -2.4 0.3 -0.7 -1.8
Mood swings 1.3 2.4 6.7 -0.7 -2.6 0.0 -0.0 -2.1
Loneliness, isolation 0.3 0.4 0.9 -0.9 0.1 0.7 0.8 0.4
Long-standing illness, disability or infirmity 0.5 0.7 1.5 1.1 0.4 -0.8 -0.5 1.2
Ever had bowel cancer screening 0.2 0.2 0.7 0.8 0.6 -0.1 0.4 0.1
Diabetes diagnosed by doctor 0.1 0.2 0.4 0.5 -0.0 0.0 0.6 0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 1.0 -0.3 0.9 0.5 0.2 1.0
Friendships satisfaction 1.1 1.3 4.9 0.8 2.2 -0.6 0.0 0.9
Qualifications: nursing, teaching 0.3 0.4 0.9 0.6 0.4 -0.8 -0.4 -0.9
Commuting to job workplace: Walk 0.4 0.4 1.0 -0.9 0.1 -0.3 1.0 -0.3
Eye problems/disorders: Cataract 0.9 1.0 1.9 1.4 0.7 -0.6 1.3 0.9
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.6 0.0 -0.3 -0.8 0.4 -0.5
Medication for cholesterol 0.6 1.0 2.9 -0.4 1.1 1.7 -0.6 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.2 0.5 -0.2 0.7 0.4 0.3 0.1
Back pain experienced in last month 1.1 1.6 3.4 -1.5 -1.1 -1.8 0.4 -1.1
Mineral and other dietary supplements 0.2 0.3 0.6 -0.3 0.7 -0.3 -0.6 0.7
Breast cancer (self-reported) 1.0 1.2 3.0 0.8 1.7 -0.8 1.0 0.7
Asthma (self-reported) 0.7 1.3 2.5 1.3 0.9 0.9 -0.9 1.6
Osteoporosis (self-reported) 0.2 0.2 0.9 0.9 -0.2 0.4 -0.4 -0.0
Osteoarthritis (self-reported) 1.4 1.8 3.8 2.0 -0.4 1.5 -1.4 0.9
Medication: Aspirin 1.2 1.6 3.7 1.8 0.2 -0.0 -0.9 1.9
Medication: Gliclazide 1.7 1.9 4.2 -0.9 -1.2 -0.5 1.8 -2.0
Illnesses of father: None of the above (group 1) 1.0 1.2 3.2 -0.6 0.2 -0.9 1.8 -1.2
Smoking status: Current 0.9 1.4 3.4 -0.5 -0.8 -1.8 -1.2 -1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 2.3 -0.7 -0.4 1.5 0.0 0.7
Whole body water mass 0.5 2.6 11.2 3.3 0.0 -0.1 -0.2 1.3
Leg predicted mass (right) 0.5 2.6 9.2 3.0 0.6 -0.1 -0.3 1.8
Arm fat mass (left) 0.2 0.7 1.3 1.0 -0.2 -0.1 -1.0 1.1
Number of self-reported non-cancer illnesses 1.8 3.2 7.2 1.2 0.9 1.4 -2.1 2.7
Average weekly champagne plus white wine intake 0.7 1.0 3.0 -0.5 0.7 -1.7 0.9 -0.6
Miserableness 1.5 2.7 6.4 -1.9 -1.6 2.5 0.4 -0.6
Guilty feelings 1.1 1.7 5.0 -2.2 -1.4 -1.0 -0.7 -0.5
Wears glasses or contact lenses 0.1 0.1 0.4 0.6 0.1 -0.1 -0.1 -0.2
Ever taken oral contraceptive pill 0.7 0.8 2.7 -1.6 0.5 -0.0 -0.2 0.9
Hearing aid user 3.7 4.2 8.1 -2.3 -1.8 -2.9 -0.4 -2.1
Mother’s age at death 0.5 0.6 1.1 -1.0 -0.4 -0.8 -0.7 -1.0
Financial situation satisfaction 0.8 0.9 2.3 -1.5 -0.8 -1.0 0.0 -0.9
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.6 -1.3 -0.3 0.0 -0.7 -0.5
Commuting to job workplace: Public transport 0.5 0.6 2.1 1.5 0.1 -0.6 0.1 -0.9
Eye problems/disorders: Glaucoma 0.7 0.9 1.4 -0.7 -0.3 -1.1 -1.2 1.0
Medication: Blood pressure 0.8 1.5 2.9 1.7 -0.8 -1.6 -1.1 0.0
Pain type(s) experienced in last month: Hip pain 0.4 0.5 0.9 0.6 0.2 0.6 0.9 1.0
Supplements: Fish oil (including cod liver oil) 1.4 1.9 4.4 2.1 1.3 0.9 0.7 1.4
High cholesterol (Self-reported) 0.2 0.3 0.6 -0.7 -0.6 0.2 0.0 0.6
Medication: Bendroflumethiazide 3.2 4.8 11.5 3.4 1.4 1.1 -0.2 3.0
Medication: Paracetamol 1.1 1.7 7.0 0.6 -0.2 2.7 -0.8 0.6
Medication: Lisinopril 0.6 0.8 2.0 1.3 -0.3 1.4 -0.2 0.2
Medication: Atorvastatin 0.8 1.0 3.2 0.7 1.0 -0.5 -1.8 0.2
Illnesses of father: High blood pressure 0.3 0.4 0.9 0.9 -0.5 -0.2 -0.9 -0.4
Alcohol drinker status: Never 0.8 1.0 4.7 -0.1 -2.2 -0.1 -0.0 -0.4
Ever smoked 0.6 1.0 2.4 -1.3 1.6 0.1 -0.9 -0.2
Basal metabolic rate 0.5 2.5 10.4 3.2 0.1 0.1 -0.4 1.5
Leg fat percentage (left) 0.2 0.6 1.1 -0.3 -1.0 0.9 -0.9 0.5
Arm fat-free mass (left) 0.4 1.9 8.0 2.8 -0.8 0.0 -0.5 0.6
Number of operations (self-reported) 2.7 4.0 7.6 1.5 1.7 2.8 -1.9 1.9
Average weekly beer plus cider intake 5.5 7.9 20.1 -4.5 -2.2 -1.6 0.6 -3.4
Irritability 0.3 0.5 1.8 0.4 -0.2 0.2 -1.3 0.6
Risk taking 0.1 0.1 0.3 -0.5 0.4 -0.0 0.1 -0.5
Ever had prostate specific antigen (PSA) test 0.8 0.9 2.4 1.1 1.5 0.9 0.3 0.2
Fractured/broken bones in last 5 years 2.0 2.5 4.9 0.2 1.5 2.2 -1.2 2.0
Age started oral contraceptive pill 0.6 0.7 3.2 0.0 -0.4 -0.5 -1.8 0.2
Diastolic blood pressure, automated reading 0.7 2.2 9.1 3.0 -0.5 -0.4 1.0 0.5
Ever depressed for a whole week 2.3 2.8 3.4 1.4 1.8 1.8 -1.7 1.6
Unable to work because of sickness or disability 1.0 1.2 2.8 1.2 0.1 1.7 0.3 1.3
Commuting to job workplace: Cycle 2.4 2.9 7.7 1.3 2.8 0.3 -2.0 1.2
Myopia 0.9 1.4 2.6 1.6 1.0 1.5 0.5 -1.0
Vascular/heart problems diagnosed by doctor 1.8 5.0 12.2 -3.2 -0.7 -0.3 1.4 -3.5
Cholesterol lowering medication 1.2 1.7 3.0 0.2 -1.3 -1.3 1.4 -1.7
Medication: Omeprazole (e.g. Zanprol) 0.5 0.5 1.7 -0.4 0.5 0.2 -1.3 0.8
Pain experienced in last month 0.1 0.1 0.3 -0.2 0.4 -0.2 0.5 0.4
Supplements: Calcium 0.8 0.9 1.8 -0.9 -0.9 1.4 -0.7 -0.6
Basal cell carcinoma (self-reported) 0.6 0.7 1.6 -0.7 0.0 -1.2 0.9 -0.9
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.8 0.3 -0.7 -0.3 1.3 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 1.3 -0.5 1.1 -0.9 -0.4 0.6
Heart disease (siblings) 0.8 1.0 2.3 0.4 -1.3 0.2 -0.9 -1.5
Alcohol drinker status: Previous 1.3 1.5 2.9 0.6 -1.0 0.9 -1.7 1.6
Pack years of smoking 0.6 1.0 2.0 1.0 1.4 -0.3 -1.3 -0.2
Impedance of whole body 0.5 2.6 11.5 -0.9 0.6 3.4 -0.3 -0.4
Leg fat mass (left) 0.2 0.8 1.5 0.9 -0.3 1.0 -0.6 1.2
Arm predicted mass (left) 0.4 1.8 7.8 2.8 -1.0 -0.2 -0.4 0.3