Hub : Genes

CDO1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1240	0.0430	3.4e-03	0.036	NA	0.037	NA	0.049	5.6e-04	NA	4.7e-04	NA	7.0e-05
2	GTEx	Adrenal Gland	0.5076	0.0846	8.0e-06	0.264	NA	0.313	NA	0.335	5.5e-10	NA	6.9e-12	NA	9.4e-13
3	GTEx	Artery Aorta	0.2670	0.0730	1.0e-03	0.150	NA	0.147	NA	0.143	1.3e-08	NA	1.7e-08	NA	2.8e-08
4	GTEx	Artery Tibial	0.2366	0.0560	2.4e-05	0.147	NA	0.122	NA	0.125	1.3e-11	NA	8.3e-10	NA	5.3e-10
5	GTEx	Cells Transformed fibroblasts	0.3390	0.0540	4.1e-12	0.266	NA	0.292	NA	0.291	4.6e-20	NA	3.4e-22	NA	4.1e-22
6	GTEx	Esophagus Gastroesophageal Junction	0.2640	0.0860	5.9e-03	-0.005	NA	0.004	NA	0.001	5.5e-01	NA	2.2e-01	NA	2.9e-01
7	GTEx	Testis	0.3490	0.0920	3.1e-04	0.049	NA	0.128	NA	0.152	3.3e-03	NA	2.6e-06	NA	2.9e-07
8	GTEx	Thyroid	0.1850	0.0480	1.0e-04	0.138	NA	0.163	NA	0.156	1.1e-10	NA	1.6e-12	NA	5.1e-12
9	METSIM	Adipose	0.0693	0.0269	2.3e-03	0.014	0.016	0.018	0.018	0.012	2.6e-03	1.3e-03	8.6e-04	7.9e-04	5.4e-03
10	ROSMAP	Brain Pre-frontal Cortex	0.1334	0.0403	9.4e-05	0.011	0.056	0.045	0.047	0.009	1.1e-02	9.0e-08	1.9e-06	9.0e-07	2.2e-02
11	YFS	Blood	0.4595	0.0384	0.0e+00	0.250	0.213	0.245	0.246	0.249	4.6e-81	7.5e-68	3.9e-79	9.7e-80	1.0e-80
12	TCGA	Breast Invasive Carcinoma	0.0446	0.0270	2.2e-03	0.020	0.015	0.017	NA	0.014	4.0e-05	3.2e-04	1.4e-04	NA	5.7e-04
13	TCGA	Cervical Squamous Cell Carcinoma	0.0820	0.0410	4.2e-03	0.039	0.026	0.030	NA	0.041	5.4e-03	2.0e-02	1.2e-02	NA	4.1e-03
14	TCGA	Lung Squamous Cell Carcinoma	0.0301	0.0170	6.7e-03	0.010	0.017	0.005	NA	0.014	2.0e-02	3.9e-03	7.6e-02	NA	9.8e-03
15	TCGA	Prostate Adenocarcinoma	0.2667	0.0644	0.0e+00	0.201	0.180	0.172	NA	0.202	1.2e-20	1.8e-18	1.3e-17	NA	8.9e-21
16	TCGA	Stomach Adenocarcinoma	0.0940	0.0360	3.5e-07	0.092	0.108	0.067	NA	0.094	3.6e-07	3.4e-08	1.3e-05	NA	2.7e-07
17	TCGA	Thyroid Carcinoma	0.2530	0.0620	0.0e+00	0.264	0.240	0.233	NA	0.258	1.1e-25	3.2e-23	2.1e-22	NA	4.9e-25

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17
Bipolar Disorder (2018)	0.9	1.4	4.8	0.4	-0.3	0.3	0.2	-0.8	-0.6	1.5	-1.2	-1.5	-2.1	-2.2	-1.4	-0.8	-1.6	-0.8	-0.9	-0.6
Bipolar Disorder or Schizophrenia	0.4	1.0	3.2	0.5	-0.6	-0.0	-0.3	-1.3	-0.9	0.6	-1.8	-1.3	-1.3	-0.6	-0.9	-1.5	-1.0	-0.7	-1.4	-0.8
Depressed Affect (Nagel 2018)	1.5	3.2	6.0	1.8	1.4	1.8	2.0	2.2	2.3	1.3	2.0	0.5	-0.1	-0.6	2.0	2.5	2.4	1.8	1.6	1.8
Depression (Nagel 2018)	0.9	1.3	3.3	0.7	0.7	1.2	1.8	1.5	0.7	1.1	1.5	0.3	-1.0	-0.3	1.8	1.3	1.4	0.9	0.4	1.0
Intelligence (Savage-Jansen 2018)	0.4	1.3	6.0	1.4	-0.2	1.2	1.4	-0.4	0.0	-1.2	-0.1	1.7	2.4	-1.8	-1.0	-0.3	-1.1	-0.4	-1.1	-0.2
Neuroticism (Nagel 2018)	0.2	0.6	2.3	1.4	0.4	1.3	1.5	0.5	0.2	0.5	0.5	0.3	-0.4	0.9	0.7	0.5	0.2	0.8	-0.6	0.5
Schizophrenia (2018)	0.2	0.5	1.7	0.3	-0.5	-0.3	-0.6	-1.1	-0.7	-0.4	-1.3	-0.5	0.1	0.9	-0.0	-1.2	-0.1	-0.2	-1.0	-0.5
Schizophrenia vs Biploar Disorder	1.2	1.5	11.0	-1.6	-0.9	-1.6	-1.7	-0.7	0.4	-1.1	-1.1	-0.9	1.0	3.3	0.8	-0.4	0.4	-0.3	-0.1	-0.7
Worry (Nagel 2018)	0.4	0.9	3.1	1.4	-0.4	1.6	1.6	-0.5	-0.8	0.2	-0.1	1.2	0.0	1.7	-0.2	-0.7	-0.9	-0.2	-1.3	-0.4
Alzheimer’s Disease (in mother)	2.9	3.4	8.0	-1.6	-1.7	-1.5	-1.9	-1.8	-1.7	-1.2	-2.2	-1.5	-2.8	-1.3	-1.8	-1.9	-2.6	-1.7	-1.9	-1.6
Alzheimer’s Disease (in father)	2.8	3.1	5.2	2.1	-2.3	1.2	1.8	-2.2	-0.1	-0.9	-1.8	1.8	0.8	1.2	-1.5	-1.9	-1.9	-2.2	-2.2	-2.2
Alzheimer’s Disease (including proxy)	1.8	2.7	7.3	-0.5	-1.8	-1.0	-0.9	-1.8	-2.3	-1.0	-1.9	-0.6	-1.2	-0.6	-1.5	-1.8	-2.7	-1.7	-2.4	-1.6
Crohns Disease (2017)	0.8	1.7	4.5	0.6	-1.6	1.0	1.0	-1.9	-0.3	-0.5	-1.8	0.7	-0.4	-0.3	-1.5	-1.8	-1.5	-2.1	-0.9	-2.0
Irritable Bowel Disease (IBD)	0.3	0.8	2.5	-0.4	-0.8	-0.4	-0.0	-1.4	-1.5	-0.2	-1.1	0.4	0.1	0.5	-0.6	-1.6	-1.3	-0.9	-1.0	-0.9
Ulcerative Colitis (UC)	0.6	1.1	4.7	-1.6	-0.2	-1.9	-1.6	-0.7	-2.2	-0.2	-0.8	-0.7	-0.5	0.8	0.2	-1.2	-0.7	-0.1	-1.0	-0.2
Major Depression (MDD)	0.5	0.6	3.9	-0.0	0.1	-0.3	-0.7	0.3	2.0	0.6	0.2	-1.7	-1.1	-0.7	-0.5	0.1	-0.2	0.0	0.1	0.2
Reaction Time	0.4	0.8	8.5	-0.9	0.7	-1.2	-0.6	0.1	-0.3	0.0	0.4	0.4	2.9	0.5	0.6	0.6	0.2	0.6	0.3	0.7
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.9	0.9	-0.6	0.9	1.1	-0.6	0.3	-1.5	-0.3	1.0	1.7	-1.1	-1.2	-0.3	-1.2	-0.8	-0.3	-0.5
Breast Cancer	0.3	0.6	2.9	-0.5	-1.1	-0.4	-0.5	-0.4	-0.3	-1.2	-0.4	0.2	-1.3	-1.7	-0.3	0.1	-0.7	-1.0	-0.7	-0.7
Ovarian Cancer	0.4	0.6	2.7	-0.9	-0.1	-0.1	-0.4	0.3	-1.4	-0.5	-0.5	-1.0	-1.6	-0.9	-1.2	-0.4	0.4	0.3	0.2	0.1
Prostate Cancer	0.7	0.9	3.2	-1.8	-0.4	-1.1	-1.3	-0.5	-0.9	-1.1	-0.5	-0.4	0.6	-1.2	-1.5	-0.5	-1.2	-0.4	-1.1	-0.3
Age at First Birth	0.1	0.2	1.0	0.4	0.1	0.3	0.4	0.1	1.0	-0.6	0.2	0.9	-0.7	0.1	0.1	-0.0	0.5	0.1	0.4	-0.1
Bipolar Disorder (2011)	1.5	1.4	7.5	1.4	-1.9	1.2	0.8	-2.5	-1.1	-0.2	-2.7	0.6	-1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.2	0.7	-0.4	0.5	-0.3	-0.5	0.3	0.4	0.3	0.1	-0.4	-0.2	0.8	-0.2	0.1	0.8	0.7	-0.1	0.3
Coronary Artery Disease (CAD)	2.9	3.5	6.9	1.6	-1.9	1.9	1.6	-2.1	0.0	-1.7	-2.0	1.4	-0.1	0.0	-2.6	-2.0	-2.3	-2.5	-2.3	-2.6
Crohns Disease (2012)	1.6	2.6	5.2	0.8	-1.9	1.5	1.4	-2.1	-0.5	-1.3	-2.0	1.4	-0.6	-0.2	-2.3	-1.8	-2.1	-2.3	-0.6	-2.2
Mean Putamen Volume	1.4	1.6	3.8	0.4	-1.4	0.3	0.5	-1.6	0.4	-1.3	-2.0	-0.6	-0.7	1.4	-0.9	-1.6	-1.8	-1.3	-1.7	-1.6
Fasting Glucose	0.3	0.4	2.9	-0.4	-0.0	-0.9	-0.7	-0.0	-0.9	-0.1	-0.1	-1.7	0.3	-0.6	-1.2	0.1	-0.2	-0.0	0.2	0.0
HbA1C	1.0	1.1	4.2	1.7	-0.4	2.1	1.9	-0.3	2.0	0.4	-0.1	-0.4	-0.7	-0.4	-0.5	-0.8	0.3	-0.6	1.3	-0.5
HDL Cholesterol	1.4	2.3	4.7	2.1	-1.9	1.9	1.8	-1.5	0.5	-2.0	-1.1	2.2	-0.2	0.1	-1.2	-1.1	-1.6	-1.8	-1.2	-1.6
LDL Cholesterol	0.7	1.2	3.2	-0.4	1.6	-0.5	-0.5	1.2	1.3	1.4	1.5	-0.3	0.7	-0.2	0.9	0.9	0.8	1.8	0.5	1.7
Lupus	1.0	1.5	5.6	-0.7	-1.2	-1.2	-1.0	-1.3	0.0	-0.4	-1.0	-0.1	-2.4	-0.9	-1.0	-1.4	-2.0	-1.5	-0.8	-1.2
Neuroticism (2016)	0.2	0.3	2.4	0.8	0.0	0.5	0.6	0.6	-0.1	0.2	0.6	0.3	-0.8	-1.6	0.1	0.2	-0.1	-0.0	-0.3	0.1
Primary Biliary Cirrhosis	0.6	0.8	2.6	1.5	-0.1	1.6	1.5	-0.4	0.5	0.6	0.1	1.6	0.3	1.4	0.1	-0.0	0.6	0.0	1.1	-0.0
Rheumatoid Arthritis	2.4	3.3	7.5	-2.7	-1.5	-1.3	-1.9	-2.2	0.4	-1.2	-2.0	-2.1	-2.3	-0.8	-0.8	-1.7	-2.5	-1.9	-1.9	-1.7
Schizophrenia (2014)	0.3	0.8	2.0	-0.4	-0.3	-1.0	-1.4	-1.0	-0.5	0.4	-1.1	-1.1	-0.9	1.3	0.6	-1.3	-0.0	-0.1	-1.0	-0.5
Triglycerides	0.2	0.3	1.0	-0.8	0.6	-0.8	-0.7	0.4	0.8	1.0	0.4	-0.2	0.1	0.5	0.4	0.5	0.4	0.6	-0.1	0.4
Type 2 Diabetes (T2D) (2012)	1.1	1.2	5.5	0.8	1.1	0.7	0.5	1.2	2.3	0.5	1.0	-0.4	0.2	0.4	1.5	1.3	1.4	1.3	0.7	1.2
Ulcerative Colitis	0.6	0.8	3.3	-1.4	-0.4	-1.8	-1.4	-0.8	-1.1	0.4	-0.8	0.1	0.3	1.2	0.2	-1.0	-0.6	-0.2	-1.0	-0.3
Blood Eosinophil Count	0.1	1.1	5.5	-1.6	0.6	-2.3	-1.9	0.2	-0.7	0.1	-0.3	-1.6	0.5	-1.5	-0.1	0.7	0.6	0.4	-0.1	0.3
Blood Platelet Count	0.0	0.3	0.9	0.7	0.6	-0.3	0.9	0.7	-0.0	0.7	0.3	-0.7	-0.6	-0.3	0.8	0.9	0.4	0.2	0.5	0.4
Blood Red Count	0.1	1.0	2.8	-0.9	-1.2	-0.9	-0.7	-0.5	1.1	-1.3	-1.1	-1.7	-1.7	-0.5	0.0	-0.2	-0.2	-1.1	-0.2	-1.0
Blood White Count	0.2	1.4	8.4	-0.7	0.9	-1.4	-0.8	1.0	2.9	0.8	1.1	-1.5	-1.1	-0.1	0.8	1.2	1.0	0.6	0.7	0.6
Heel T-Score	0.1	0.9	4.6	0.3	1.1	-0.4	0.1	1.0	0.8	2.1	1.1	0.4	0.8	0.6	0.6	0.6	0.7	1.2	1.1	1.3
BMI	0.5	2.6	5.7	0.4	1.5	1.0	0.5	2.4	1.6	1.1	2.3	-1.5	-0.7	-1.9	1.8	2.0	1.7	1.9	1.6	2.1
Height	3.1	59.1	217.2	-13.7	-3.3	-13.9	-14.7	-4.1	-3.5	0.3	-6.2	-13.0	-7.3	-2.5	-3.3	-4.4	-4.3	-4.0	-4.6	-3.8
Waist Hip Ratio (WHR)	0.4	1.7	6.8	-2.0	-0.7	-0.6	-1.4	0.1	-2.5	-0.2	-0.7	-1.4	-2.6	-1.1	-1.8	-0.3	-0.3	-1.1	-0.4	-0.9
Systolic Blood Pressure	0.3	1.7	7.8	-2.3	-0.7	-2.4	-2.8	-0.7	-0.3	-0.5	-0.6	-1.9	-0.2	0.6	0.0	-0.8	-0.9	-0.8	-1.3	-0.8
Smoking Status	1.2	2.9	7.0	0.6	2.5	0.1	0.2	2.5	0.6	0.7	2.2	-0.4	-0.3	-0.8	1.6	2.6	1.8	2.5	2.2	2.5
Allergy or Eczema	0.6	1.7	4.8	-2.0	1.1	-2.2	-2.2	0.5	-1.6	1.5	-0.4	-1.9	0.0	-1.4	-0.3	0.4	0.9	1.1	-0.1	0.8
Cardiovascular Disease	0.5	1.7	4.9	-1.4	1.3	-1.5	-1.7	1.3	-0.3	2.2	0.6	-1.9	-0.7	-1.3	1.1	1.2	1.1	1.4	0.4	1.4
Hypothyroidism (self reported)	1.0	2.2	4.4	1.2	-2.0	2.1	1.9	-1.7	-0.2	-1.1	-0.9	0.7	1.7	0.6	-1.6	-1.7	-1.7	-1.9	-0.9	-1.7
Respiratory disease	0.8	1.7	5.6	-1.5	1.6	-1.1	-1.5	1.5	-0.1	2.4	1.2	-1.0	0.4	-0.9	0.1	1.1	1.8	1.3	1.2	1.3
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.2	1.1	-0.0	1.0	1.0	0.5	-1.1	0.7	0.4	0.8	-0.5	1.5	0.7	0.3	-0.5	-0.4	-1.1	-0.3
Lung FEV1/FVC ratio	0.7	3.3	12.2	-0.3	1.4	0.8	0.4	2.0	3.5	0.4	2.4	0.3	1.9	-1.4	2.2	2.9	1.2	1.5	2.2	2.0
Lung FVC	0.6	2.9	11.6	-3.4	-1.2	-2.5	-2.9	-1.3	-1.8	-1.7	-1.4	-1.6	-0.7	0.3	-1.1	-0.8	-1.5	-1.3	-1.3	-1.3
Neuroticism	0.4	1.0	4.3	2.0	0.2	2.1	2.1	0.1	1.1	0.7	0.4	0.7	-0.3	0.4	0.5	0.2	-0.4	0.1	-0.8	-0.0
Chronotype (morning person)	0.3	0.7	1.7	0.9	0.3	1.2	1.1	0.9	0.3	1.3	0.9	0.0	-0.6	0.9	1.2	-0.2	0.5	0.8	0.2	0.8
Hair Pigment	0.1	2.3	5.1	-0.3	-1.9	0.1	-0.2	-1.9	-1.3	-2.3	-1.6	-1.4	-1.8	-0.4	-1.6	-1.9	-1.4	-1.9	-1.8	-1.8
Tanning	0.1	1.1	4.8	1.3	0.5	1.1	1.5	1.1	0.1	0.3	1.3	2.2	-0.3	0.5	1.3	1.2	1.0	0.3	1.0	0.5
Hand grip strength (left)	0.5	1.2	4.5	-1.7	-0.1	-2.0	-1.8	0.7	0.9	-1.6	0.1	-2.1	0.2	-0.1	-0.4	0.4	0.6	0.1	1.2	0.1
Number of treatments/medications taken	0.7	1.2	5.9	-1.4	1.5	-1.3	-1.2	1.0	-0.8	2.4	0.6	-0.7	0.5	-0.7	0.4	0.5	0.5	1.2	0.0	1.2
Average weekly spirits intake	0.3	0.4	1.9	-0.6	0.0	0.1	0.1	-1.1	0.0	-0.7	-0.6	-1.0	0.0	-0.3	-0.4	-0.4	-1.4	-0.0	-1.0	-0.2
Sensitivity / hurt feelings	0.5	0.8	3.4	0.9	0.5	0.8	0.6	0.6	1.8	1.2	0.4	-0.9	-0.9	1.2	0.9	0.5	0.5	0.8	0.7	0.6
Frequency of depressed mood in last 2 weeks	1.2	1.7	5.6	1.9	0.7	2.2	2.4	0.8	1.8	1.4	1.4	1.1	-0.2	-0.5	1.4	1.0	0.9	0.7	0.2	0.6
Hearing difficulty/problems: Yes	0.2	0.3	0.9	0.4	0.5	0.6	0.2	0.6	0.9	0.4	0.8	-0.0	0.9	-0.5	0.8	0.2	0.3	0.2	-0.2	0.2
Relative age of first facial hair	0.2	0.4	3.3	-0.1	0.3	-0.1	0.2	0.6	0.6	-0.5	0.7	0.0	1.8	0.5	0.2	0.5	1.1	0.2	0.9	0.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	3.7	0.3	1.1	1.3	0.9	1.2	0.8	0.6	1.0	-1.0	0.1	-0.4	-0.5	1.0	1.2	0.6	1.9	0.7
Ever used hormone-replacement therapy (HRT)	0.6	0.8	5.3	-0.1	0.5	0.0	-0.2	0.2	-1.9	0.6	0.2	-0.7	-1.4	-2.3	0.4	0.0	-0.0	0.6	-0.0	0.7
Ever had hysterectomy (womb removed)	0.3	0.3	1.0	-0.4	0.0	-0.7	-0.6	-0.3	-1.0	0.9	-0.3	-0.5	-0.9	-0.7	-0.5	-0.6	-0.0	-0.2	-0.8	-0.2
Systolic blood pressure, automated reading	0.3	0.8	3.6	-1.1	0.4	-1.8	-1.9	0.2	-1.2	0.5	0.1	-1.1	0.1	0.6	0.9	0.2	0.1	0.4	-0.5	0.3
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	2.0	0.5	0.4	0.7	0.9	0.8	1.1	-0.0	1.1	1.4	0.1	1.1	0.3	0.6	-0.0	0.1	0.6	0.2
Angina	0.2	0.3	1.2	-0.2	0.5	0.2	-0.1	0.8	1.1	0.9	0.5	-0.0	-0.9	0.1	-0.0	0.1	-0.0	0.4	-0.3	0.4
Medication for hormone replacement therapy	0.7	0.7	2.3	1.2	0.0	1.4	1.5	-0.8	-0.6	1.0	-0.3	1.4	0.9	0.4	-0.3	-0.8	-0.3	0.3	-0.8	0.0
Vitamin and mineral supplements	1.4	1.9	4.1	0.1	-1.9	0.6	0.4	-2.0	-0.7	-1.6	-1.9	0.3	-0.7	1.0	-1.8	-2.0	-1.5	-1.6	-0.9	-1.8
Supplements: Zinc	0.2	0.2	0.8	-0.0	0.6	-0.1	-0.6	0.2	-0.6	-0.6	-0.2	-0.3	0.2	0.9	0.6	0.5	-0.1	0.5	0.4	0.4
Medication: Co-codamol	0.5	0.5	1.2	-0.8	0.8	-0.7	-0.7	0.7	0.1	0.5	0.9	0.3	0.8	-1.1	0.9	0.9	-0.2	1.0	0.3	1.0
Medication: Metformin	1.4	1.9	4.2	1.5	-1.5	1.5	1.5	-1.2	-0.1	-1.4	-0.8	0.8	-0.1	2.0	-0.8	-1.2	-2.0	-1.6	-2.1	-1.6
Diabetes (father)	1.0	1.3	3.5	0.3	1.2	0.9	0.8	1.4	1.2	0.5	1.7	1.9	0.8	1.1	0.9	1.3	1.3	0.8	0.9	0.8
Diabetes (mother)	0.9	1.2	3.7	-0.5	1.2	-0.4	-0.2	1.9	1.1	0.9	1.1	-0.4	-0.9	-0.8	1.5	1.1	1.3	1.4	0.9	1.4
Severe depression (siblings)	0.3	0.3	2.2	1.5	0.4	0.7	1.1	0.2	0.5	-0.1	0.3	0.5	-0.0	-0.5	0.3	0.1	-0.9	0.1	-0.5	0.3
Pack years adult smoking proportion	0.3	0.5	1.6	0.6	0.1	0.6	0.8	0.4	0.1	-1.2	0.7	0.7	-0.6	-1.0	-1.3	0.3	-0.2	-0.1	0.9	0.2
Impedance of leg (right)	1.9	9.0	21.4	-4.5	-2.6	-4.6	-4.5	-2.9	-2.7	0.6	-3.0	-3.3	-2.6	1.8	-2.7	-3.0	-2.2	-2.4	-2.1	-2.5
Leg fat-free mass (left)	0.3	1.8	10.0	-1.0	0.7	-0.6	-1.3	1.3	1.4	0.2	0.6	-2.6	-1.5	-3.2	0.5	1.0	0.6	0.5	0.6	0.8
Trunk fat percentage	0.8	3.2	12.5	-2.1	-1.1	-2.1	-2.8	-0.7	-1.1	1.4	-1.1	-3.2	-3.5	-1.2	-0.7	-1.2	-1.3	-1.2	-1.3	-0.9
Hand grip strength (right)	0.5	1.4	5.2	-2.0	0.4	-2.3	-2.0	1.0	1.3	-0.1	0.3	-1.8	0.6	-0.9	0.1	0.9	1.1	0.4	1.2	0.5
Townsend deprivation index at recruitment	1.0	1.4	3.2	-1.2	-0.8	-1.0	-1.4	-1.5	-1.2	0.2	-1.6	-1.0	-1.0	0.8	-1.8	-1.3	-1.4	-1.2	-0.9	-1.2
Current tobacco smoking	1.5	2.5	5.5	0.6	1.8	0.7	0.8	2.0	0.7	0.6	2.2	1.0	1.0	-1.6	1.6	2.2	1.9	1.8	2.3	2.0
Average weekly fortified wine intake	3.1	3.7	20.6	-2.9	1.3	-2.6	-2.7	1.5	-0.1	2.0	0.7	-4.5	-2.2	-0.1	1.5	1.1	0.6	1.1	-0.1	1.0
Maternal smoking around birth	1.2	1.8	4.3	-1.2	-1.0	-1.3	-1.6	-1.3	-1.7	0.2	-1.1	-1.0	-1.9	-0.4	-1.5	-1.5	-2.1	-1.2	-1.4	-1.0
Fed-up feelings	1.2	2.2	7.7	1.3	1.6	1.4	1.5	1.6	2.8	1.5	1.3	-0.1	-0.6	-0.3	2.2	1.5	1.4	1.6	0.4	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.5	0.4	1.0	1.0	1.3	1.6	0.9	1.5	1.3	0.0	-0.7	-1.4	1.7	1.6	1.9	1.1	0.7	1.1
Relative age voice broke	0.3	0.5	1.8	-0.2	-0.6	-0.3	-0.2	-0.6	0.2	-0.1	-0.9	-1.0	-0.2	1.0	-1.4	-0.7	-0.5	-0.8	-0.5	-0.9
Taking other prescription medications	0.4	0.6	2.9	0.2	1.3	0.7	0.5	0.5	-1.0	1.7	0.5	0.5	0.3	0.2	-0.7	0.6	0.9	1.0	0.7	0.7
Age when periods started (menarche)	0.7	1.6	3.6	0.2	-1.9	0.0	-0.0	-1.8	-1.0	-1.7	-1.6	-0.1	-0.3	-0.3	-1.1	-1.3	-1.8	-1.9	-0.9	-1.7
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	4.9	-0.7	1.3	-1.1	-0.7	1.4	-0.3	2.2	0.9	-0.4	-0.2	-1.4	1.2	0.8	1.5	1.3	0.9	1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.8	9.5	0.4	3.1	0.6	0.8	2.6	1.9	2.1	2.6	-0.1	0.8	-0.1	2.3	2.2	2.2	2.8	1.7	2.7
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.8	1.6	-1.1	1.2	1.3	-0.8	-0.7	-1.7	-0.9	-0.2	-0.7	0.5	-0.7	-0.9	-0.7	-0.4	-0.4	-0.5
Qualifications: CSEs or equivalent	0.2	0.3	1.7	0.3	-0.1	0.2	0.7	0.0	0.0	0.4	-0.2	0.5	-0.2	1.3	0.6	-0.0	1.3	0.2	-0.0	-0.1
Serious illness, injury or assault to yourself	0.3	0.4	1.2	0.0	1.1	0.5	0.2	0.8	-0.0	0.5	0.7	0.9	-0.7	-0.5	0.3	0.7	0.4	0.7	0.8	0.8
High blood pressure	0.6	1.8	6.7	-1.9	-0.7	-2.6	-2.5	-0.7	-1.2	1.0	-1.4	-1.8	-1.4	0.6	-0.1	-0.6	-0.7	-0.4	-1.3	-0.6
Hayfever, allergic rhinitis or eczema	0.6	1.3	4.4	-2.1	0.8	-1.9	-2.0	0.6	-0.5	1.4	-0.4	-1.6	-0.6	-1.1	-0.6	0.3	1.0	0.8	0.5	0.6
Multivitamins +/- minerals	1.8	2.3	5.8	0.0	2.0	-0.1	-0.1	1.9	0.4	1.3	1.7	-0.5	0.3	-2.1	2.2	2.4	1.9	1.8	1.1	1.9
Stomach or abdominal pain in last month	0.8	1.0	4.4	0.1	-1.4	0.2	0.1	-1.3	0.6	0.0	-1.4	0.4	-2.1	-0.4	-0.9	-1.0	-0.6	-1.4	-0.1	-1.4
Supplements: Glucosamine	1.0	1.3	3.2	-0.3	1.6	-0.2	-0.5	1.5	-1.1	0.9	1.2	-1.4	-0.2	-1.7	1.3	0.8	0.9	1.6	0.2	1.8
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	2.4	0.9	-0.6	1.1	1.3	-0.7	-0.7	-0.1	-1.3	0.4	-1.6	-0.9	-1.4	-1.5	-0.9	-0.8	-1.1	-0.9
Medication: Atenolol	0.3	0.3	1.6	0.3	0.4	0.1	0.4	-0.1	-0.6	0.8	0.1	1.3	-0.1	0.3	0.6	-0.2	-0.4	0.5	-1.2	0.3
Medication: Levothyroxine sodium	1.0	1.7	4.2	0.8	-1.7	0.8	0.6	-1.8	-0.8	-0.3	-1.5	0.7	1.5	0.4	-1.4	-2.0	-1.9	-1.7	-0.8	-1.5
Sitting height	1.2	8.5	27.0	-4.7	-1.8	-5.2	-5.0	-1.7	-1.9	0.2	-2.6	-4.4	-2.9	0.0	-2.4	-2.0	-2.1	-2.1	-1.7	-2.0
Chronic bronchitis/emphysema (father)	0.4	0.5	1.8	-1.1	0.3	-1.3	-1.3	-0.4	-0.4	1.1	0.3	0.6	0.3	0.7	0.4	0.3	0.6	0.3	0.2	0.2
High blood pressure (mother)	0.4	0.5	1.5	0.8	1.2	0.5	0.7	1.1	0.0	-0.3	0.5	-0.6	-0.2	-0.5	0.2	0.8	0.8	1.1	0.4	0.9
Body mass index (BMI)	0.6	2.4	4.8	1.6	1.5	2.0	1.5	2.0	1.1	1.2	2.0	-0.4	-0.8	-2.2	1.6	1.7	1.2	1.4	1.3	1.7
Impedance of leg (left)	1.8	8.8	24.8	-4.6	-2.2	-5.0	-4.8	-2.5	-2.9	0.6	-2.8	-3.4	-2.7	1.9	-2.6	-2.7	-1.9	-2.0	-1.8	-2.2
Leg predicted mass (left)	0.4	1.9	10.8	-1.1	0.7	-0.7	-1.4	1.3	1.3	0.3	0.7	-2.7	-1.6	-3.3	0.5	1.0	0.5	0.5	0.6	0.9
Trunk fat mass	0.9	3.7	15.1	-2.5	-0.9	-2.3	-3.1	-0.3	-0.5	1.2	-0.9	-3.9	-3.8	-1.8	-0.5	-0.9	-1.2	-1.0	-1.1	-0.7
Waist circumference	0.5	2.0	10.7	-1.1	0.4	-0.5	-1.3	1.3	-0.2	1.4	0.6	-2.6	-3.3	-2.8	0.2	0.8	0.3	0.3	0.5	0.7
Number of incorrect matches in round	1.2	2.0	7.3	-0.9	-0.6	-1.8	-1.6	-0.6	-2.2	-0.5	-1.5	-2.4	-2.7	0.3	-0.2	-1.2	-1.0	-0.5	-1.7	-0.7
Past tobacco smoking	0.3	0.5	2.1	-0.6	-0.4	-0.5	0.0	-0.7	-0.4	0.9	-0.3	1.4	1.3	0.4	0.2	-1.0	-0.2	-0.5	-0.6	-0.5
Alcohol usually taken with meals	2.3	3.7	12.7	-3.2	-0.5	-3.6	-3.6	-0.2	-1.3	0.1	-1.4	-2.7	-2.9	0.2	1.1	-1.3	-0.6	-0.3	-1.8	-0.5
Nervous feelings	0.7	1.4	2.8	0.7	-1.1	1.2	0.9	-1.3	-1.1	-0.1	-1.3	1.3	-0.9	0.4	-1.7	-1.0	-1.4	-1.3	-1.6	-1.4
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	6.2	0.6	1.4	1.3	1.2	0.7	2.3	2.5	1.5	0.2	1.6	-0.0	2.5	1.0	0.7	1.5	-0.3	1.4
Hearing difficulty/problems with background noise	0.4	0.6	2.5	-0.0	0.6	0.3	0.3	0.7	0.8	1.6	1.0	-0.1	-0.9	0.5	1.4	0.5	1.0	0.3	0.2	0.3
Hair/balding pattern: Pattern 2	0.4	0.4	2.2	-0.2	0.0	-0.6	-0.5	0.2	-0.7	-0.0	0.4	-0.5	-0.6	-1.4	-0.8	0.8	-0.0	0.2	1.5	0.4
Had menopause	0.6	0.8	6.5	0.6	0.4	0.5	0.3	0.3	-1.8	0.3	0.3	1.4	0.1	-2.5	-0.5	0.4	-0.7	0.1	0.0	0.4
Had other major operations	0.5	0.6	4.5	0.6	-0.5	0.8	0.5	0.1	0.1	0.3	0.1	2.1	0.1	1.2	0.3	0.7	0.5	-0.6	1.2	-0.5
Forced vital capacity (FVC)	1.9	7.5	32.5	-5.6	-0.9	-5.1	-5.7	-0.7	-0.2	0.6	-1.7	-4.7	-2.1	0.9	-1.2	-0.6	-0.6	-1.1	-0.5	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	5.7	-0.8	2.4	-0.4	-0.3	2.2	1.4	2.0	2.1	-0.6	1.2	0.4	1.9	1.9	2.2	2.3	1.2	2.1
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	4.1	1.4	0.1	0.7	1.3	0.1	1.9	1.8	0.1	1.1	2.0	0.4	0.7	0.8	1.1	0.5	1.2	0.5
Qualifications: None of the above	0.4	0.8	5.1	0.6	0.8	-0.1	0.2	0.7	-1.0	2.3	0.9	0.2	-0.5	-0.7	0.2	1.0	1.1	0.8	1.1	0.8
Financial difficulties in last 2 years	0.3	0.3	1.7	1.3	-0.2	0.8	1.0	-0.5	0.3	0.2	-0.2	0.7	-0.9	-0.1	0.1	-0.5	-0.3	-0.2	-0.5	-0.3
Mouth/teeth dental problems	1.0	1.6	6.6	2.6	-0.5	1.6	2.1	-0.4	0.3	-0.4	-0.3	2.6	0.5	-0.1	-0.8	-1.0	-1.2	-0.6	-1.3	-0.5
Heart attack	1.1	1.5	3.2	0.2	-1.3	0.4	-0.1	-1.4	-0.5	-0.9	-1.4	0.1	-1.6	1.4	-1.0	-1.6	-1.7	-1.3	-1.8	-1.5
Allergy	1.1	2.4	7.2	2.7	-1.2	2.5	2.7	-0.9	1.0	-2.3	0.0	1.7	0.5	1.9	0.7	-0.8	-1.4	-0.9	-1.0	-0.9
Pain all over the body in last month	0.7	0.8	3.7	0.1	0.8	0.4	0.3	1.0	0.0	1.0	0.9	0.3	0.6	-0.1	0.0	1.6	1.5	0.2	1.9	0.3
Diabetes (self-reported)	0.7	1.0	4.4	2.0	-0.2	2.1	2.0	0.5	0.3	0.6	0.3	1.1	-0.3	0.3	0.5	-0.2	-1.1	-0.7	-1.0	-0.5
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	5.3	-1.9	0.6	-2.3	-1.9	0.5	-0.8	0.9	0.2	-0.8	-0.1	-0.8	-1.0	0.5	1.2	0.3	0.7	0.2
Medication: Ramipril	0.4	0.5	2.3	0.7	-0.1	0.4	0.4	-0.2	-0.4	0.8	-0.3	-0.1	-1.5	-1.3	0.6	-0.4	-0.7	-0.3	-1.5	-0.3
Medication: Simvastatin	0.9	1.4	4.7	-2.2	-0.3	-1.4	-1.7	-0.4	-1.9	-0.3	-1.3	-1.8	-0.6	0.1	-1.0	-0.9	-0.9	-0.4	-1.2	-0.3
Fluid intelligence score	0.5	1.1	3.9	1.3	-0.3	1.3	1.5	-0.4	-0.7	-1.3	-0.4	1.1	1.4	-2.0	-1.3	-0.1	-0.7	-0.6	0.1	-0.3
Illnesses of siblings	0.4	0.6	5.7	-0.7	0.2	-0.2	-0.6	0.2	0.6	-0.3	-0.6	-2.4	0.6	-0.9	0.6	-0.1	0.3	0.6	-0.4	0.4
Neuroticism score	0.4	0.8	3.1	1.5	0.4	1.5	1.5	0.5	1.7	0.8	0.4	-0.2	-0.8	0.6	0.9	0.4	-0.1	0.5	-0.6	0.4
Weight	0.6	3.1	15.8	-2.3	0.6	-1.9	-2.7	1.1	0.3	1.1	0.4	-4.0	-2.9	-2.9	0.4	0.6	0.2	0.4	0.4	0.7
Impedance of arm (right)	1.7	7.7	15.6	-3.5	-2.8	-3.9	-3.9	-3.4	-2.2	0.3	-3.5	-2.4	-1.5	1.6	-2.6	-3.0	-2.0	-2.7	-2.5	-2.9
Arm fat percentage (right)	0.2	0.7	4.0	-0.0	-0.1	0.2	-0.3	0.2	0.1	1.3	0.2	-1.6	-2.0	-1.6	0.4	-0.1	-0.2	-0.1	-0.2	0.1
Trunk fat-free mass	0.5	2.6	11.9	-2.3	0.9	-1.7	-2.4	1.3	0.7	-0.2	0.5	-3.5	-2.1	-3.0	0.3	0.9	0.2	0.5	0.5	0.8
Hip circumference	0.8	3.4	12.6	-2.3	1.0	-2.1	-2.9	1.3	0.5	1.6	0.7	-3.5	-2.7	-2.8	1.0	1.0	0.5	1.0	0.9	1.3
Time employed in main current job	0.3	0.3	1.0	0.4	0.9	-0.2	0.4	0.4	0.3	0.7	0.6	-0.0	0.3	0.2	0.6	0.3	0.2	1.0	-0.6	0.9
Alcohol intake versus 10 years previously	0.2	0.3	1.1	0.7	-0.2	0.9	1.0	-0.1	1.1	-0.1	-0.0	-0.4	-0.5	0.0	-0.6	-0.3	0.3	-0.3	0.5	-0.3
Father’s age at death	2.5	3.3	7.5	0.8	2.5	0.6	0.7	2.5	0.5	0.9	2.4	0.5	1.1	-0.1	1.9	2.1	2.7	2.6	2.6	2.4
Worrier / anxious feelings	0.4	0.8	5.7	0.7	0.6	0.8	0.9	0.3	0.3	0.5	0.3	1.4	1.1	2.4	0.6	0.2	-0.3	0.8	-0.6	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.9	1.4	0.5	1.6	1.7	0.3	1.6	1.6	0.6	0.7	0.5	-1.0	0.8	0.2	1.2	0.5	0.1	0.5
Falls in the last year	1.5	2.0	4.1	-1.8	1.8	-1.3	-1.9	1.9	0.0	1.7	1.1	-1.2	-1.3	-0.6	1.3	2.0	0.6	1.2	1.3	1.4
Hair/balding pattern: Pattern 3	0.4	0.7	3.0	0.1	-0.2	0.4	0.6	-0.4	-0.4	-0.4	-0.0	1.7	0.9	1.7	0.1	-0.6	-1.0	-0.1	-1.4	-0.1
Number of live births	0.2	0.2	0.9	-0.2	0.0	-0.2	-0.2	0.2	-0.9	-0.8	0.7	-0.1	0.9	0.3	0.3	0.3	0.4	0.1	0.9	0.1
Forced expiratory volume in 1-second (FEV1)	1.3	4.3	21.2	-4.6	-0.8	-3.6	-4.3	-0.4	0.7	0.6	-1.1	-3.6	-1.0	0.7	-0.5	-0.1	-0.3	-0.9	-0.2	-0.8
Pulse rate	0.3	0.5	1.4	0.2	-1.1	0.2	0.5	-0.7	-1.1	-0.4	-1.1	1.2	-0.0	-0.1	-0.9	-0.2	-0.1	-0.9	-0.4	-1.0
Happiness	0.9	1.1	4.3	2.0	-0.8	1.7	1.7	-0.6	0.8	-1.4	-0.4	2.1	0.1	-0.3	-0.4	-0.2	-0.2	-0.4	-0.0	-0.4
Noisy workplace	0.1	0.1	0.6	-0.1	0.2	-0.8	-0.4	0.0	0.4	-0.1	-0.3	0.7	0.4	0.7	-0.2	0.0	-0.2	0.4	0.4	0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.3	1.1	-0.4	1.1	0.9	-0.6	0.3	0.0	-1.0	-0.0	0.4	0.4	-1.1	-0.5	-0.7	-0.4	-0.4	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	2.4	0.0	0.5	-0.2	0.2	0.1	-0.1	0.2	0.1	-0.5	-0.5	-1.5	-0.4	0.6	-0.8	-0.2	1.0	0.3
Mouth/teeth dental problems: Dentures	0.6	1.0	4.1	-2.0	0.6	-1.9	-1.8	0.7	-0.7	0.0	0.2	-1.3	-0.4	0.4	0.7	0.7	0.6	0.7	0.7	0.7
Asthma	1.7	3.4	11.4	-1.8	2.3	-1.9	-2.0	2.0	-1.2	3.4	1.2	-1.0	0.5	-1.7	0.9	1.9	2.6	1.7	1.9	1.7
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	5.1	0.5	1.8	0.7	0.8	1.6	1.0	1.6	1.9	1.0	2.2	-1.5	1.4	1.8	1.8	1.7	1.6	1.8
Medication: Cholesterol lowering	0.7	1.1	2.4	0.6	-1.1	0.8	0.5	-1.1	-0.5	-1.0	-1.2	-0.6	0.3	-0.1	-1.4	-1.5	-1.6	-1.2	-1.5	-1.1
Depression (self-reported)	1.7	2.1	4.8	2.0	1.6	1.9	2.2	1.3	1.4	1.0	1.4	0.2	0.1	-1.0	1.8	1.1	0.7	1.9	0.9	1.9
Medication: Lansoprazole	0.4	0.4	1.8	-0.5	-0.2	-0.6	-0.6	-0.6	-1.0	0.6	-0.4	-0.0	0.7	1.3	-0.8	-0.7	-0.7	-0.3	-0.5	-0.4
Prospective memory result	1.3	1.6	6.5	-1.7	-0.7	-1.4	-1.5	-0.9	-2.5	-0.6	-1.0	-1.2	-2.0	0.6	0.2	-1.1	-0.7	-0.7	-1.3	-0.8
Lung cancer (father)	0.7	0.8	2.9	-1.1	-0.4	-1.7	-1.5	-0.9	-1.1	-0.4	-0.5	-1.1	0.0	1.5	0.2	-0.5	-0.4	-0.2	-1.2	-0.2
Illnesses of mother	0.2	0.3	1.6	0.6	-0.3	0.5	0.9	0.0	0.2	0.5	0.6	0.5	1.3	-0.0	0.6	0.4	0.3	-0.3	0.7	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.3	27.6	-5.2	0.0	-4.3	-4.7	0.2	1.1	0.7	-0.2	-4.3	-0.8	-0.6	-0.0	0.4	0.1	-0.1	0.1	-0.1
Pulse wave Arterial Stiffness index	0.5	0.5	2.2	-0.2	0.6	-0.6	-1.0	0.2	1.2	0.8	-0.0	-0.5	-0.1	-1.5	0.1	0.2	-0.5	0.8	0.9	1.0
Impedance of arm (left)	2.0	9.4	15.6	-3.3	-3.4	-3.5	-3.8	-3.9	-2.4	-0.2	-4.0	-2.2	-1.6	2.0	-3.2	-3.6	-2.6	-3.2	-3.2	-3.5
Arm fat mass (right)	0.3	1.2	6.2	-0.4	0.3	-0.0	-0.6	0.7	0.5	1.2	0.4	-2.3	-2.4	-2.5	0.5	0.3	-0.1	0.2	-0.0	0.5
Trunk predicted mass	0.4	2.5	11.0	-2.2	1.0	-1.6	-2.3	1.4	0.8	-0.1	0.6	-3.3	-2.1	-3.0	0.4	0.9	0.2	0.6	0.6	0.9
Standing height	2.3	22.6	83.5	-8.5	-2.2	-8.3	-9.1	-2.1	-1.5	-0.3	-3.6	-8.1	-5.1	-1.8	-2.9	-2.5	-2.5	-2.6	-2.3	-2.4
Length of working week for main job	0.3	0.3	1.2	-0.4	0.5	0.5	-0.1	0.4	1.1	0.4	0.7	-0.2	-1.0	-0.7	0.1	0.7	-0.7	0.4	0.1	0.6
Exposure to tobacco smoke at home	1.0	1.1	7.6	0.9	-1.2	0.5	0.8	-1.3	-0.7	-0.4	-1.4	1.0	0.1	-0.4	-2.8	-0.9	-0.9	-0.9	0.4	-1.0
Breastfed as a baby	2.2	2.8	7.0	0.2	2.3	-0.2	-0.2	2.4	1.2	0.8	2.2	-0.4	1.6	-0.7	2.0	2.7	1.4	2.5	1.0	2.4
Tense / ‘highly strung’	1.1	1.8	4.1	1.6	-1.3	1.1	1.3	-1.5	0.5	-0.3	-0.8	-0.2	-1.7	1.4	-1.1	-1.6	-1.7	-1.3	-2.0	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.3	-0.9	0.4	-0.4	-0.7	-0.2	1.0	1.1	0.0	-0.8	-0.1	-0.4	0.5	0.2	-0.1	0.7	-0.1	0.5
Hair/balding pattern: Pattern 4	0.1	0.3	1.4	0.3	0.2	0.5	0.5	0.5	0.5	0.2	0.1	-0.9	-0.7	0.9	1.2	-0.1	0.5	0.4	-0.2	0.2
Birth weight of first child	0.6	1.0	3.1	-0.6	-1.7	-0.4	-0.4	-0.9	-0.7	-0.8	-1.4	0.2	-1.0	0.9	-1.0	-0.8	-0.8	-1.8	-0.2	-1.6
Peak expiratory flow (PEF)	0.7	1.6	6.2	-2.5	-1.0	-1.8	-2.2	-1.0	-0.2	0.4	-1.7	-1.0	-0.7	-1.2	-0.7	-0.6	-0.8	-1.2	-0.5	-1.1
Pulse wave reflection index	1.6	2.0	5.0	-0.5	2.0	-0.9	-1.1	1.4	2.2	1.5	1.3	-1.2	0.8	-1.5	1.0	1.2	0.4	1.7	1.8	2.0
Ever highly irritable/argumentative for 2 days	1.4	1.7	4.6	0.2	-1.1	0.6	0.2	-2.0	-1.4	-0.7	-2.1	-1.0	-0.9	0.7	-0.7	-1.9	-1.9	-1.1	-1.8	-1.3
Loud music exposure frequency	0.3	0.3	1.6	-0.5	-0.2	-0.4	-0.8	-0.1	0.5	0.2	-0.3	-0.1	-1.3	0.4	0.3	-0.3	-1.1	-0.3	-0.8	-0.2
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	6.9	2.1	0.1	2.6	2.2	0.2	1.9	-0.8	0.1	1.2	1.9	0.9	-0.4	0.3	0.9	0.0	1.1	-0.1
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	3.3	-0.2	1.1	1.0	0.6	0.9	0.9	1.2	1.2	0.0	1.4	-0.4	0.6	1.6	1.7	1.0	1.8	1.0
Blood clot in the leg (DVT)	0.8	1.1	2.7	-0.2	1.5	-0.1	-0.2	1.1	-0.0	0.8	1.3	0.5	1.1	-0.5	0.3	1.1	1.5	1.3	1.6	1.4
Medication: Paracetamol	1.1	1.8	4.7	-0.8	1.9	-1.2	-0.9	1.7	-0.7	1.6	1.4	-0.3	-0.0	-0.4	1.2	1.8	2.2	1.6	1.3	1.6
Headache pain in last month	0.1	0.1	0.7	0.1	0.2	0.1	0.4	0.1	-0.2	-0.6	0.2	0.1	-0.4	-0.9	-0.5	-0.3	0.4	0.1	-0.0	-0.1
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	5.1	0.0	1.2	-0.1	0.2	1.2	0.6	0.7	1.6	0.9	0.1	0.5	1.0	1.8	2.2	1.1	2.3	1.1
Glaucoma (self-reported)	1.5	1.8	5.0	1.3	-0.8	1.6	1.3	-1.2	-1.9	-2.0	-1.0	1.2	-0.5	-0.7	-2.2	-1.0	-1.6	-1.2	-0.7	-1.0
Gout (self-reported)	0.4	0.5	2.5	0.6	-0.1	1.0	0.9	0.1	-0.6	-0.7	0.3	1.3	0.6	1.6	0.2	-0.2	0.3	0.4	-0.6	0.0
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	5.0	1.8	-1.3	2.2	1.9	-1.3	-0.1	0.0	-0.8	1.2	1.9	0.9	-1.0	-1.2	-1.3	-1.3	-0.3	-1.1
Medication: Amlodipine	0.3	0.4	2.8	-0.3	-0.2	-0.1	-0.1	-0.1	-0.0	0.3	-0.6	-1.7	-0.4	0.4	0.8	-0.7	-0.6	-0.1	-1.0	-0.2
Medication: Ventolin 100micrograms inhaler	0.5	0.6	3.9	0.3	0.6	0.4	0.3	0.1	-2.0	1.3	0.1	1.7	0.1	0.2	-0.6	0.1	0.7	0.3	0.5	0.2
Birth weight	0.6	1.4	3.9	-0.1	1.6	-0.7	-0.2	1.7	0.4	1.8	0.9	-0.4	-0.4	0.2	1.4	1.3	1.0	2.0	1.1	1.8
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.9	-1.3	0.3	-1.2	-1.2	-0.3	0.5	1.4	-0.1	-0.6	0.9	1.3	-0.0	-0.6	0.2	0.2	-0.1	0.1
High blood pressure (siblings)	0.9	1.2	3.4	0.6	1.4	0.1	0.5	1.3	-0.9	1.4	1.6	1.8	-0.2	1.0	1.2	1.4	1.0	0.8	1.2	0.8
Forced vital capacity (FVC), Best measure	2.0	7.2	35.9	-6.0	0.1	-5.3	-5.6	0.1	0.3	0.9	-0.7	-4.9	-1.0	-0.4	-0.4	0.1	0.1	-0.1	0.1	-0.1
Body fat percentage	0.6	2.3	10.5	-1.8	-0.7	-1.6	-2.3	-0.2	-0.8	1.5	-0.5	-3.0	-3.2	-1.4	-0.3	-0.7	-0.9	-0.7	-0.9	-0.4
Leg fat percentage (right)	0.5	1.7	9.1	-1.6	-0.3	-1.3	-1.7	0.3	-0.8	1.4	0.1	-2.8	-3.0	-1.3	0.5	-0.2	-0.5	-0.2	-0.4	0.1
Arm fat-free mass (right)	0.4	2.1	9.1	-1.5	0.7	-1.2	-1.8	1.2	0.6	-0.2	0.6	-2.8	-2.5	-3.0	-0.0	0.8	0.0	0.3	0.6	0.7
Exposure to tobacco smoke outside home	0.2	0.3	1.7	0.4	-0.7	0.3	0.2	-0.7	-1.3	-0.0	-0.6	1.1	0.1	-0.1	-0.5	-0.5	-0.5	-0.1	-0.4	-0.3
Comparative body size at age 10	1.5	4.3	11.3	2.3	2.1	2.8	2.8	1.9	2.9	0.9	2.5	1.6	0.3	-0.8	3.4	1.2	1.0	2.2	0.6	2.3
Number of full brothers	1.0	1.2	3.1	-1.2	-0.9	-1.1	-1.5	-1.0	-0.2	-1.3	-0.9	-1.8	-1.0	-1.1	-1.0	-1.1	-1.3	-0.8	-1.0	-0.7
Worry too long after embarrassment	0.9	1.5	9.3	-1.3	-0.5	-1.1	-0.9	-1.0	-0.6	-0.2	-1.0	-0.7	0.1	1.9	0.2	-1.5	-1.7	-0.2	-3.0	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.9	3.5	-0.9	1.6	-1.4	-1.4	1.6	-0.2	1.9	1.0	-1.4	-0.5	-0.7	1.0	1.7	1.4	1.8	1.8	1.7
Wheeze or whistling in the chest in last year	1.0	1.8	10.6	-0.2	1.7	0.1	0.1	1.3	-0.2	3.2	0.8	-0.1	-0.4	-1.2	0.2	1.3	1.9	1.8	1.6	1.6
Number of children fathered	1.5	1.7	6.0	-1.9	0.2	-2.4	-2.4	0.0	-1.2	0.2	-0.5	-1.7	-1.7	-1.0	-0.2	-0.3	-1.4	-0.1	-1.6	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	3.0	-0.3	0.2	-0.5	-0.7	-0.6	-0.2	-0.3	-0.4	-1.2	0.0	-0.3	-0.7	-0.7	-1.5	-0.1	-1.7	-0.2
Age at first live birth	0.3	0.5	3.0	-0.1	-0.5	-0.4	-0.2	-0.5	0.1	-0.9	-0.8	-0.0	-0.2	1.7	0.0	-0.8	-1.2	-0.3	-1.1	-0.5
Pulse wave peak to peak time	0.5	0.6	2.0	-0.2	-0.7	0.2	0.6	-0.4	-1.4	-1.0	-0.2	0.0	-0.1	1.3	-0.4	-0.4	0.3	-0.9	-1.1	-1.2
Health satisfaction	0.4	0.5	2.1	1.5	-0.1	1.2	1.0	-0.1	-0.3	0.2	-0.5	0.6	-0.7	-1.3	-0.8	0.4	0.1	0.1	0.5	-0.1
Shortness of breath walking on level ground	0.7	0.8	3.5	-0.8	-0.6	-1.7	-1.3	-0.5	-0.4	1.9	-0.8	-1.2	-0.3	1.1	-0.3	-0.2	-0.6	-0.1	-0.2	-0.2
Qualifications: College or University degree	0.3	0.9	3.0	-1.4	0.4	-1.7	-1.7	0.1	-1.2	0.8	-0.4	-1.2	1.7	0.2	-0.9	0.2	-0.5	0.0	-0.4	0.2
Eye problems/disorders: None of the above	0.9	1.0	3.6	0.9	-1.9	0.0	0.5	-1.2	0.1	-0.6	-1.5	-0.8	-0.2	0.4	-0.0	-1.1	0.2	-1.5	-0.8	-1.7
Mouth/teeth dental problems: Loose teeth	1.2	1.4	4.3	0.3	-1.4	0.5	-0.0	-1.3	-2.1	-1.1	-1.4	-0.2	-0.6	-0.8	-1.9	-0.9	-1.9	-1.3	-0.8	-1.2
Emphysema/chronic bronchitis	0.3	0.4	1.1	0.5	-0.5	0.8	0.5	-0.9	-0.3	-0.7	-0.6	0.3	-0.2	0.2	-1.0	-0.7	-0.4	-0.7	-0.3	-0.7
Medication for pain relief, constipation, heartburn	1.4	2.4	6.5	-0.3	-2.5	-0.8	-0.5	-2.0	0.3	-1.6	-2.0	-0.1	-0.9	1.9	-1.3	-2.2	-1.8	-1.8	-1.4	-1.9
Neck or shoulder pain in last month	0.1	0.2	1.3	-0.5	0.5	0.3	-0.0	0.1	-0.4	0.0	-0.0	-0.2	-1.1	-0.9	0.1	-0.2	0.2	0.4	0.3	0.4
Medication: Blood pressure	0.2	0.4	2.2	0.2	-0.6	0.2	-0.0	-0.2	0.1	-1.0	-0.7	-0.5	-0.3	-0.1	0.3	-0.8	-1.5	-0.4	-1.4	-0.4
Angina (self-reported)	0.2	0.3	1.2	-0.1	0.5	0.3	-0.1	0.7	1.1	1.0	0.5	-0.0	-0.9	0.2	-0.1	0.1	0.0	0.4	-0.3	0.3
Migraine (self-reported)	0.8	1.0	2.7	-0.2	1.6	-0.6	-0.5	1.4	-0.5	0.6	0.9	-0.6	-0.4	-0.8	1.2	0.9	1.3	1.6	0.8	1.5
Medication: Ibuprofen	3.0	3.5	6.3	-0.1	2.3	0.3	0.2	2.4	1.3	1.7	2.5	1.0	2.4	-0.7	2.1	2.3	2.5	2.3	2.0	2.3
Medication: Allopurinol	0.6	0.8	2.0	1.3	0.7	1.4	1.3	0.8	0.6	-0.4	1.1	0.9	0.8	0.4	0.9	0.1	0.9	1.2	0.4	1.0
Medication: Omeprazole	0.5	0.6	2.5	0.4	0.5	0.2	0.1	0.3	0.7	-0.4	-0.0	-1.6	1.1	-1.2	-0.7	0.7	1.1	0.1	1.3	0.0
Medication: Seretide 50 evohaler	0.8	0.9	3.0	-0.5	1.4	-0.6	-0.3	1.1	-1.7	1.7	0.6	0.3	-0.8	-0.4	-0.1	0.7	0.9	1.1	0.5	1.0
Mean time to correctly identify matches	0.3	0.6	2.6	-1.3	0.5	-1.5	-1.2	0.1	-1.0	-0.1	0.3	-0.3	1.6	0.4	0.2	0.4	-0.2	0.5	-0.2	0.5
Heart disease (mother)	0.3	0.4	1.6	-1.3	0.2	-1.1	-1.2	-0.1	-0.4	0.2	-0.2	-0.5	-0.7	0.8	0.6	-0.3	0.3	0.3	-0.6	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	2.2	-0.4	0.4	-0.5	-0.4	0.1	-0.0	0.7	-0.4	-0.5	-1.0	-1.5	0.5	0.2	-0.4	0.2	-0.3	0.2
Whole body fat mass	0.7	2.9	14.4	-2.0	-0.2	-1.9	-2.5	0.3	-0.0	1.3	-0.2	-3.8	-3.6	-2.2	-0.1	-0.3	-0.7	-0.4	-0.7	-0.1
Leg fat mass (right)	0.5	2.0	9.1	-1.3	0.4	-1.0	-1.6	1.0	0.2	1.5	0.5	-3.0	-3.0	-2.6	0.7	0.3	-0.1	0.3	0.0	0.6
Arm predicted mass (right)	0.4	2.2	9.4	-1.4	1.1	-1.1	-1.7	1.6	0.8	0.0	0.9	-2.8	-2.3	-3.1	0.6	1.0	0.3	0.8	0.7	1.1
Pulse rate, automated reading	0.2	0.7	1.5	0.4	-1.2	0.6	0.9	-0.9	-0.5	-0.7	-0.9	1.1	-0.9	0.6	-0.5	-0.9	-0.5	-0.9	-1.2	-1.0
Alcohol intake frequency.	0.5	1.1	3.5	-0.8	-1.9	-0.6	-0.1	-1.0	-0.1	-1.4	-1.2	0.7	-0.2	0.8	-0.1	-1.2	-1.2	-1.5	-1.1	-1.5
Comparative height size at age 10	1.4	7.8	38.6	-5.7	-0.5	-5.5	-6.2	0.3	-1.1	1.1	-0.9	-3.9	-3.2	-0.8	-0.8	-0.3	-0.0	-0.7	-0.1	-0.6
Number of full sisters	1.2	1.5	7.0	2.2	-0.6	2.6	2.5	-0.6	1.2	-1.1	0.2	0.7	0.0	0.4	0.7	-0.8	-0.9	-0.5	-0.5	-0.4
Suffer from ‘nerves’	0.4	0.6	3.3	1.4	0.7	1.8	1.6	0.3	0.4	0.4	0.6	0.3	-0.3	0.1	0.8	0.6	0.2	0.6	0.1	0.6
Overall health rating	0.8	1.7	5.9	0.9	0.8	1.7	1.5	1.4	1.7	1.7	1.2	0.8	-0.9	-2.4	0.8	1.1	1.1	0.8	1.2	1.0
Chest pain or discomfort	0.4	0.6	5.4	-0.1	0.2	0.1	0.1	-0.7	0.2	2.3	-0.6	-0.2	-0.7	0.1	0.6	-1.2	-0.6	0.0	-1.1	-0.1
Had major operations	1.1	1.2	6.7	1.0	-0.9	1.1	0.9	-0.7	2.6	0.4	-1.1	-1.2	-1.8	-0.3	-0.8	-1.4	-0.3	-0.7	-0.5	-0.8
Age at last live birth	0.3	0.4	2.6	0.7	-0.2	0.8	0.7	-0.3	0.3	-0.4	-0.8	0.5	-0.3	1.6	0.5	-0.8	-0.8	0.1	-0.5	-0.1
Family relationship satisfaction	1.3	1.6	5.7	2.3	0.3	2.2	2.4	0.4	2.1	-0.5	0.5	1.9	0.6	-0.2	0.5	0.6	0.3	0.5	0.6	0.6
Leg pain on walking	0.6	0.7	7.5	-0.7	-0.2	-0.9	-0.8	-0.8	-2.7	0.3	-0.9	0.2	-0.5	-0.4	-0.5	-0.4	-0.8	-0.1	-0.2	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	4.1	-0.6	0.2	-0.0	-0.2	0.6	-0.3	-1.1	0.5	0.3	-1.0	-2.0	0.3	0.1	0.1	-0.2	-0.2	0.0
Commuting to job workplace: Car/motor vehicle	0.5	0.6	4.5	0.9	-0.3	0.2	0.7	-0.0	-0.4	0.4	0.1	2.1	0.9	0.6	1.1	-0.2	1.1	-0.3	-0.5	-0.4
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.7	-1.6	0.2	-1.5	-1.6	0.5	0.7	-0.3	0.2	-1.0	1.1	0.4	0.4	0.4	1.0	0.6	0.6	0.5
Medication: Aspirin	0.5	0.7	3.2	-1.1	0.8	-0.5	-1.2	0.5	-0.1	0.3	0.1	-0.8	-1.8	-1.7	0.4	0.3	-0.5	0.3	-0.4	0.4
Supplements: Vitamin C	0.2	0.3	0.9	-0.2	0.3	-0.1	-0.3	0.8	0.8	0.4	0.5	-0.9	-0.1	-0.9	0.6	0.4	0.2	0.1	-0.1	0.3
Knee pain experienced in last month	1.9	3.0	5.3	-1.7	2.3	-1.7	-2.0	1.5	1.5	1.5	1.2	-2.2	-0.9	-1.8	1.7	1.5	1.4	2.2	1.7	2.2
Hypertension (Self-reported)	0.6	1.7	5.7	-1.8	-0.8	-2.4	-2.4	-0.7	-1.0	1.0	-1.5	-1.6	-1.3	0.6	-0.2	-0.6	-0.8	-0.6	-1.4	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	4.5	-1.5	-0.4	-1.9	-1.9	-0.3	-1.8	1.0	-1.4	-2.1	0.2	0.2	-0.7	-0.5	-0.0	-0.3	-0.3	-0.5
Illnesses of father: Heart disease	2.1	2.9	7.7	0.2	-2.6	-0.1	-0.3	-2.2	0.4	-1.5	-2.8	-0.3	-1.4	-0.2	-1.5	-2.1	-1.9	-2.5	-1.5	-2.5
Illnesses of siblings: Diabetes	0.8	1.0	2.3	1.5	0.9	1.2	1.5	1.1	0.4	0.4	1.1	1.0	0.1	-1.0	-0.3	1.1	0.5	0.8	1.3	1.0
Smoking status: Previous	0.3	0.5	3.7	0.4	-0.1	0.3	-0.3	-0.1	-0.6	-0.8	-0.6	-1.4	-1.9	0.7	-0.5	0.2	-0.4	-0.0	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.4	14.7	-3.8	-0.4	-3.2	-3.6	0.1	0.5	0.1	-0.3	-3.3	-1.8	-1.7	-1.1	-0.1	-0.1	-0.4	-0.8	-0.4
Whole body fat-free mass	0.4	2.5	10.7	-1.8	1.0	-1.4	-2.0	1.6	1.0	0.2	0.8	-3.1	-1.9	-3.3	0.5	1.2	0.5	0.7	0.8	1.0
Leg fat-free mass (right)	0.4	1.9	9.4	-1.1	1.0	-0.8	-1.5	1.6	1.4	0.3	0.8	-2.4	-1.2	-3.1	0.7	1.3	0.8	0.8	0.8	1.1
Arm fat percentage (left)	0.2	0.6	4.2	0.2	-0.5	0.6	-0.1	-0.1	0.2	0.9	-0.1	-1.5	-2.0	-1.4	-0.0	-0.4	-0.5	-0.5	-0.6	-0.3
Average weekly red wine intake	1.9	2.8	10.6	-2.8	0.1	-2.9	-3.3	-0.3	-1.4	-0.1	-1.3	-2.5	-2.6	0.2	1.1	-0.9	-0.6	-0.1	-1.3	-0.2
Handedness (chirality/laterality): Left-handed	1.3	1.6	4.1	-0.3	-1.0	-0.6	-0.9	-1.8	-1.3	-0.3	-2.0	-1.9	-2.0	1.4	-0.3	-1.3	-0.9	-1.2	-0.5	-1.4
Mood swings	0.7	1.2	2.8	1.5	0.4	1.6	1.6	1.0	1.6	1.4	0.7	0.4	-0.8	0.3	1.7	1.1	1.2	0.8	-0.1	0.5
Loneliness, isolation	0.7	0.9	2.7	-0.3	1.1	-0.2	-0.1	1.1	0.6	1.6	1.0	-1.0	-0.2	-0.3	0.9	1.1	1.3	1.2	1.0	1.2
Long-standing illness, disability or infirmity	1.7	2.6	6.7	-0.8	2.6	0.0	-0.5	2.0	-0.7	2.4	1.7	-1.5	0.7	-1.9	0.5	1.8	1.1	2.3	1.3	2.3
Ever had bowel cancer screening	0.5	0.6	2.1	-0.3	1.1	-0.2	-0.1	0.9	-0.8	1.0	1.1	-0.5	-0.1	-0.7	1.4	0.8	0.5	0.8	-0.0	0.9
Diabetes diagnosed by doctor	0.5	0.8	2.3	1.5	-0.5	1.5	1.5	-0.2	-0.2	0.3	-0.2	1.0	-0.5	0.7	0.1	-0.5	-1.3	-1.0	-1.2	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	3.4	3.7	8.3	-0.2	2.3	-0.9	-0.8	2.5	2.9	1.0	2.1	-1.2	1.3	-1.0	1.7	2.5	2.3	2.4	2.4	2.4
Friendships satisfaction	0.6	0.7	1.6	0.4	0.9	0.8	0.5	0.6	1.3	0.7	0.4	0.5	0.4	-0.7	1.0	0.7	1.2	1.2	1.0	1.0
Qualifications: nursing, teaching	1.3	2.0	4.0	0.9	-1.4	0.9	0.9	-1.6	0.0	-1.7	-1.6	-0.8	-1.9	0.2	-2.0	-1.5	-1.9	-1.5	-1.5	-1.6
Commuting to job workplace: Walk	0.4	0.4	2.0	1.4	0.0	1.3	1.3	0.0	0.5	-0.8	0.0	-0.7	-0.3	-0.2	0.2	-0.3	-0.3	0.0	0.5	0.0
Eye problems/disorders: Cataract	0.5	0.6	3.2	0.8	0.8	1.3	0.8	0.1	0.7	-0.2	0.6	1.8	1.0	0.7	0.3	0.0	-0.6	0.8	-0.2	0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.8	0.2	-0.9	0.8	0.6	-0.6	0.3	-0.9	-0.4	-0.9	-0.1	0.5	0.3	-0.2	0.0	-0.7	-0.2	-0.7
Medication for cholesterol	0.5	0.8	5.9	1.1	-0.5	0.8	0.6	-0.2	2.4	-1.0	-0.0	-0.0	1.3	0.7	0.0	0.3	0.4	-0.3	0.9	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.2	-0.0	1.2	0.2	0.6	1.5	-0.4	0.9	1.4	-0.1	-0.8	-0.0	0.5	1.1	1.1	1.0	1.3	1.0
Back pain experienced in last month	0.9	1.4	5.6	1.1	-0.6	1.7	1.5	-1.2	-1.3	-0.5	-1.1	2.4	0.7	0.3	-1.4	-1.1	-1.0	-0.5	-0.9	-0.8
Mineral and other dietary supplements	1.2	1.6	3.5	-0.1	-1.9	0.4	0.5	-1.8	0.2	-1.2	-1.5	1.4	-0.3	0.6	-1.7	-1.3	-1.4	-1.8	-0.8	-1.9
Breast cancer (self-reported)	1.6	1.9	5.1	2.3	1.4	1.9	2.1	1.3	0.4	1.6	1.2	1.2	0.5	-1.6	0.9	1.4	1.4	0.8	0.9	0.9
Asthma (self-reported)	1.9	3.8	12.0	-1.7	2.5	-1.8	-1.8	2.2	-1.0	3.5	1.5	-1.2	0.4	-1.6	1.0	2.1	2.7	1.9	2.0	1.9
Osteoporosis (self-reported)	0.2	0.3	0.9	-0.3	0.5	-0.7	-0.4	0.3	-0.9	1.0	0.3	-0.5	-0.4	-0.2	-0.4	0.1	-0.6	0.2	-0.8	0.2
Osteoarthritis (self-reported)	2.7	3.5	7.1	-1.4	2.7	-1.3	-1.5	2.3	0.2	1.9	2.1	-2.0	-0.9	-2.2	2.3	2.1	1.2	2.1	1.2	2.4
Medication: Aspirin	0.5	0.6	2.9	-1.1	0.7	-0.4	-1.1	0.3	-0.5	0.1	-0.1	-0.4	-1.7	-1.6	0.4	0.2	-0.7	0.2	-0.6	0.3
Medication: Gliclazide	3.2	3.6	10.8	1.5	-1.9	1.3	1.1	-2.0	-2.1	-0.7	-2.3	0.3	-1.2	2.2	-0.9	-2.6	-2.6	-1.8	-3.3	-2.0
Illnesses of father: None of the above (group 1)	3.8	4.7	10.1	-0.4	2.5	0.2	0.4	3.1	0.5	1.2	3.0	-0.7	1.5	-1.5	2.3	3.0	3.0	2.6	3.2	2.8
Smoking status: Current	1.7	2.8	5.9	0.8	1.9	0.7	0.9	2.1	1.1	0.5	2.4	1.0	1.0	-1.9	1.4	2.2	1.9	1.9	2.4	2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	9.3	-3.0	-0.8	-2.4	-2.6	-0.5	-0.6	-1.3	-0.8	-2.7	-0.7	-0.0	-0.6	-0.4	-0.5	-1.0	-0.7	-1.0
Whole body water mass	0.4	2.4	10.3	-1.8	1.0	-1.4	-2.0	1.5	0.9	0.1	0.7	-3.2	-1.9	-3.2	0.4	1.0	0.4	0.7	0.7	1.0
Leg predicted mass (right)	0.3	1.9	9.5	-1.1	0.9	-0.7	-1.4	1.5	1.5	0.3	0.8	-2.4	-1.2	-3.1	0.7	1.3	0.7	0.8	0.7	1.1
Arm fat mass (left)	0.3	1.2	6.9	-0.3	0.3	0.1	-0.6	0.8	0.5	0.9	0.5	-2.2	-2.4	-2.6	0.5	0.3	-0.1	0.1	0.0	0.5
Number of self-reported non-cancer illnesses	1.1	1.9	7.8	-1.3	2.0	-1.2	-1.3	1.4	-1.1	2.8	0.7	-1.5	0.2	-1.6	-0.4	1.3	0.7	1.6	0.9	1.5
Average weekly champagne plus white wine intake	0.7	1.0	3.9	-0.3	0.8	-0.9	-0.2	1.0	-0.1	-0.3	1.4	-0.1	2.0	1.1	1.6	0.6	0.5	1.5	-0.5	1.3
Miserableness	2.2	3.8	12.1	0.7	1.9	0.6	0.9	2.5	3.5	2.2	2.1	-0.7	-0.1	-0.6	2.3	2.9	2.7	1.9	1.9	1.8
Guilty feelings	1.1	1.7	4.0	0.5	-1.3	0.2	0.2	-2.0	-1.3	-1.0	-1.9	-0.9	-0.4	0.4	-1.7	-1.9	-1.7	-1.3	-1.3	-1.4
Wears glasses or contact lenses	0.9	1.0	3.5	0.7	1.0	0.5	0.7	1.2	-0.4	1.1	0.9	1.9	0.4	-0.2	1.4	1.7	0.6	0.8	1.0	0.9
Ever taken oral contraceptive pill	0.7	0.8	6.2	-1.1	0.5	-0.4	-1.0	0.2	1.5	0.7	0.0	-2.5	0.4	-0.4	0.4	0.3	-0.4	0.3	0.6	0.6
Hearing aid user	3.7	4.1	14.1	1.6	-2.3	1.8	1.4	-2.3	-0.2	-1.5	-2.0	-0.3	-1.6	-0.4	-2.5	-2.2	-3.8	-2.7	-2.2	-2.5
Mother’s age at death	1.9	2.4	5.4	0.7	-2.1	0.9	0.8	-1.7	-0.2	-1.3	-2.1	0.9	-2.3	-0.4	-2.1	-1.5	-1.5	-2.1	-0.6	-2.2
Financial situation satisfaction	1.4	1.7	8.2	2.6	0.2	2.5	2.2	-0.6	-0.4	-0.1	-0.5	2.9	-0.0	1.2	0.2	-0.1	-0.4	0.0	-0.1	-0.2
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.8	-0.7	-1.2	0.0	0.1	-1.1	-1.1	-1.2	-1.1	0.3	-0.8	0.1	-0.9	-1.2	-1.1	-1.3	-0.5	-1.3
Commuting to job workplace: Public transport	0.6	0.7	2.3	-1.3	0.2	-1.4	-1.5	-0.2	-0.4	0.1	-0.8	-1.5	-0.3	-0.8	-0.4	0.6	0.0	0.5	1.1	0.3
Eye problems/disorders: Glaucoma	0.6	0.8	3.6	-0.0	-0.4	0.7	-0.1	-0.8	-1.5	-1.5	-0.7	0.6	-0.8	-0.9	-1.9	-0.7	-0.8	-0.4	-0.1	-0.4
Medication: Blood pressure	0.4	0.7	1.9	-0.7	-0.5	-0.9	-0.8	-0.7	-1.2	0.6	-0.8	-0.4	-1.4	-0.1	-0.6	-1.0	-1.0	-0.7	-1.3	-0.5
Pain type(s) experienced in last month: Hip pain	1.1	1.4	3.3	-0.7	1.7	-0.5	-1.0	1.3	-0.9	1.1	1.5	0.4	-0.1	-1.1	1.6	1.1	0.7	1.7	0.9	1.8
Supplements: Fish oil (including cod liver oil)	1.1	1.4	3.5	0.6	1.6	0.1	0.1	1.7	1.2	0.4	1.9	-0.7	1.1	-0.9	1.0	1.4	0.8	1.6	1.0	1.8
High cholesterol (Self-reported)	0.3	0.6	1.7	-0.5	0.9	-0.5	-0.6	0.7	-1.2	0.8	0.2	-1.3	0.2	-0.4	-0.2	0.2	1.2	1.0	0.7	0.9
Medication: Bendroflumethiazide	2.0	3.1	5.1	-1.7	-1.9	-2.0	-1.9	-1.3	-1.3	-1.2	-2.2	-1.5	-1.9	0.9	-1.4	-1.3	-2.3	-2.0	-2.2	-1.9
Medication: Paracetamol	1.4	2.2	5.6	-0.7	2.1	-0.9	-0.8	2.2	0.3	0.9	1.7	0.3	0.0	-0.5	1.9	2.1	2.4	1.8	1.6	1.8
Medication: Lisinopril	1.3	1.7	4.0	-1.6	1.5	-2.0	-1.7	1.5	-0.8	1.8	0.8	-1.4	0.4	-0.7	0.5	0.7	1.2	1.7	0.8	1.6
Medication: Atorvastatin	1.2	1.5	7.0	2.6	-0.2	2.6	2.0	-0.3	2.0	0.1	0.4	0.6	-0.9	-1.1	-0.6	-0.9	-0.5	-0.2	-0.6	-0.2
Illnesses of father: High blood pressure	0.5	0.6	1.6	-0.1	-0.9	-0.4	-0.2	-0.8	0.0	-1.0	-0.8	0.0	-0.8	0.9	-0.5	-1.3	-0.7	-1.0	-1.0	-1.0
Alcohol drinker status: Never	1.2	1.5	5.2	-1.2	-1.1	-1.3	-1.2	-1.4	-1.3	0.1	-1.1	-0.2	-0.6	-0.2	0.1	-1.4	-2.3	-1.1	-2.1	-0.9
Ever smoked	0.6	1.1	2.7	0.6	0.9	0.3	0.2	1.3	1.6	-0.6	1.0	-1.2	-0.4	-1.4	0.7	1.6	0.9	1.0	1.6	1.2
Basal metabolic rate	0.5	2.7	12.0	-1.9	0.9	-1.4	-2.2	1.5	1.0	0.4	0.7	-3.5	-2.2	-3.3	0.5	1.1	0.5	0.6	0.7	1.0
Leg fat percentage (left)	0.4	1.6	8.4	-1.5	0.1	-1.2	-1.7	0.8	-0.7	1.4	0.6	-2.5	-2.9	-1.2	0.7	0.2	-0.1	0.2	-0.0	0.4
Arm fat-free mass (left)	0.6	3.1	11.4	-1.7	1.6	-1.4	-1.9	2.0	0.8	0.6	1.2	-3.2	-2.2	-3.4	1.0	1.4	0.8	1.3	1.2	1.6
Number of operations (self-reported)	0.9	1.3	5.0	-0.2	0.8	-0.1	-0.3	1.2	2.2	2.1	0.6	-0.8	-1.8	-1.1	1.1	0.6	1.5	0.4	0.9	0.4
Average weekly beer plus cider intake	1.9	2.7	8.6	2.3	-1.3	2.9	2.9	-1.3	-0.7	-1.8	-0.7	2.0	0.5	2.3	-1.3	-0.9	-0.2	-1.2	-0.6	-1.4
Irritability	0.5	0.8	2.7	1.6	0.7	1.2	1.2	0.7	1.4	0.8	0.5	-0.2	-1.1	-0.8	0.3	0.4	0.8	0.8	0.5	0.6
Risk taking	0.4	0.6	3.2	0.0	0.6	-0.2	-0.0	-0.4	1.2	0.4	0.4	-1.5	-0.3	-1.8	-1.0	0.1	-1.2	-0.2	-0.4	0.2
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.8	-1.3	-0.3	-1.1	-0.9	-0.5	0.2	-0.6	-0.7	-1.0	0.8	1.3	0.3	-0.6	-0.7	-0.1	-0.6	-0.2
Fractured/broken bones in last 5 years	0.1	0.2	0.6	0.1	0.8	-0.0	-0.1	0.4	-0.0	-0.5	0.4	0.2	-0.8	-0.6	-0.3	0.4	0.4	0.4	0.6	0.3
Age started oral contraceptive pill	0.4	0.5	1.5	0.1	1.1	0.4	0.2	1.0	-0.2	0.6	0.8	-0.6	-0.9	-1.2	0.4	0.9	0.4	0.7	0.8	0.9
Diastolic blood pressure, automated reading	0.4	1.2	4.9	-1.5	1.0	-1.9	-2.2	0.9	-0.3	0.7	0.3	-1.0	0.3	0.5	1.1	0.7	1.3	1.3	0.5	1.0
Ever depressed for a whole week	0.3	0.4	2.9	-0.6	0.0	-0.9	-0.5	-0.2	0.8	1.7	-0.4	-1.0	-0.2	0.1	0.5	0.3	0.0	0.2	0.4	0.3
Unable to work because of sickness or disability	0.6	0.7	1.9	-0.7	-0.8	-1.3	-1.2	-0.5	1.4	0.7	-0.6	-1.2	-0.9	-0.1	-0.6	-0.5	-0.9	-0.8	-0.1	-0.7
Commuting to job workplace: Cycle	0.5	0.6	2.1	0.0	-0.8	-0.2	-0.1	-1.1	0.8	-0.3	-1.1	-0.3	-0.6	0.4	-1.4	-0.8	-0.9	-1.0	-0.4	-1.0
Myopia	0.2	0.2	2.0	0.3	-0.1	-0.2	0.3	0.1	0.3	0.4	-0.1	-0.7	0.2	1.4	0.6	0.2	0.5	0.1	0.4	0.0
Vascular/heart problems diagnosed by doctor	0.4	1.0	3.2	1.3	0.1	1.8	1.8	0.3	1.2	-1.1	0.9	1.1	1.1	-0.7	-0.2	0.2	0.5	-0.0	1.2	0.1
Cholesterol lowering medication	0.7	1.0	5.0	-1.4	1.1	-0.9	-1.0	0.8	-1.2	1.1	0.4	-0.6	-2.2	-1.1	-0.2	0.4	0.2	0.9	-0.2	0.9
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.7	0.9	0.1	0.9	0.8	-0.3	0.9	-0.1	-0.5	-1.3	0.8	-1.2	-1.0	0.1	0.5	-0.4	0.5	-0.4
Pain experienced in last month	0.8	1.3	2.5	-1.3	-1.6	-1.2	-1.0	-0.9	-0.2	-1.4	-0.7	-1.4	-0.8	0.3	-0.8	-1.1	-1.2	-1.4	-1.6	-1.2
Supplements: Calcium	0.3	0.4	1.3	0.1	0.7	-0.3	-0.3	0.4	-0.1	0.9	0.1	-1.1	-1.1	-0.8	0.6	0.1	-0.3	0.2	-0.7	0.3
Basal cell carcinoma (self-reported)	1.0	1.1	4.6	-0.0	-1.3	0.7	0.6	-0.9	-0.1	-1.7	-0.8	0.5	-0.3	0.5	-0.6	-0.9	-2.1	-1.0	-2.1	-0.9
Heart attack/myocardial infarction (self-reported)	1.4	1.8	4.2	0.1	-1.5	0.5	-0.1	-1.6	-0.3	-0.9	-1.4	0.2	-1.8	1.4	-1.1	-1.8	-1.9	-1.4	-2.0	-1.6
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.2	-0.5	1.4	-0.3	-0.5	0.8	-0.3	1.0	1.1	0.3	0.9	-0.3	0.1	0.9	1.3	1.1	1.5	1.2
Heart disease (siblings)	0.5	0.6	4.6	0.7	-0.7	0.2	0.4	-0.6	-0.2	0.4	0.0	2.1	0.2	0.3	-0.2	-0.7	-1.1	-0.8	-0.4	-0.6
Alcohol drinker status: Previous	1.3	1.5	6.6	-2.2	0.3	-2.6	-2.6	0.3	-1.8	-0.7	-0.3	-0.9	-0.8	-0.8	0.3	0.3	-0.9	0.1	-1.0	0.1
Pack years of smoking	0.4	0.6	3.1	0.1	-0.5	0.1	0.2	-0.2	-0.5	-1.8	0.1	0.6	-1.2	-0.4	-1.6	-0.2	-0.9	-0.7	0.1	-0.4
Impedance of whole body	2.1	10.7	21.4	-4.1	-3.2	-4.6	-4.6	-3.7	-3.0	0.1	-3.7	-2.9	-2.1	2.3	-3.3	-3.6	-2.5	-3.0	-2.8	-3.2
Leg fat mass (left)	0.5	2.0	8.9	-1.3	0.5	-1.1	-1.7	1.1	0.2	1.4	0.7	-2.9	-3.0	-2.5	0.6	0.5	0.1	0.3	0.3	0.7
Arm predicted mass (left)	0.6	3.1	12.0	-1.8	1.4	-1.6	-2.2	1.8	0.7	0.5	1.1	-3.4	-2.4	-3.5	0.6	1.3	0.5	1.0	1.1	1.4