Hub : Genes

TICAM2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0410	0.0220	0.0380	-0.001	-0.002	0.000	-0.002	0.000	0.56000	0.6100	0.3600	0.65	0.3200
2	GTEx	Skin Sun Exposed Lower leg	0.0750	0.0320	0.0079	-0.001	NA	0.005	NA	0.006	0.36000	NA	0.1200	NA	0.0970
3	TCGA	Breast Invasive Carcinoma	0.0223	0.0120	0.0017	0.015	0.010	0.008	NA	0.009	0.00042	0.0028	0.0062	NA	0.0045
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0414	0.0247	0.0016	-0.001	0.012	0.010	NA	0.004	0.45000	0.0140	0.0220	NA	0.1100
5	TCGA	Stomach Adenocarcinoma	0.0450	0.0320	0.0085	0.009	0.017	0.028	NA	0.015	0.06700	0.0210	0.0037	NA	0.0260

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.6	0.9	1.2	-0.9	1.1	1.1	1.0	0.6
Bipolar Disorder or Schizophrenia	1.0	2.3	3.4	-1.8	1.7	1.3	1.8	-0.9
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	-0.6	0.2	0.2	0.6	-0.4
Depression (Nagel 2018)	0.6	0.9	2.5	1.6	-1.2	0.1	-0.4	0.6
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.3	-1.0	-0.8	1.2	0.8	1.1
Neuroticism (Nagel 2018)	0.1	0.1	0.4	0.4	-0.6	-0.1	0.0	-0.2
Schizophrenia (2018)	0.9	2.0	2.7	-1.5	1.3	0.8	1.6	-1.6
Schizophrenia vs Biploar Disorder	0.3	0.4	0.9	0.9	0.9	-0.4	-0.5	0.3
Worry (Nagel 2018)	0.7	1.5	3.1	1.8	-0.5	-1.3	-1.5	0.4
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	0.3	0.1	0.1	-0.2	0.1
Alzheimer’s Disease (in father)	0.5	0.5	1.7	-1.3	-0.8	0.3	0.6	-0.1
Alzheimer’s Disease (including proxy)	0.5	0.7	1.2	-0.6	-0.6	1.1	0.6	1.1
Crohns Disease (2017)	0.2	0.4	1.5	0.5	0.1	0.4	-0.2	1.2
Irritable Bowel Disease (IBD)	0.2	0.5	1.2	-0.2	0.3	0.9	0.4	1.1
Ulcerative Colitis (UC)	0.1	0.3	0.5	-0.3	0.7	0.7	0.5	0.2
Major Depression (MDD)	0.3	0.4	1.7	0.3	1.3	0.2	0.5	-0.2
Reaction Time	0.2	0.3	0.8	-0.3	-0.9	-0.1	-0.5	0.7
Verbal and Numeric Reasoning (VNR)	0.3	0.6	2.4	-0.8	-0.0	0.4	-0.1	1.5
Breast Cancer	0.4	0.9	2.2	1.1	-0.1	-1.1	-0.3	-1.5
Ovarian Cancer	0.7	0.9	2.6	1.0	0.8	0.4	-0.3	1.6
Prostate Cancer	1.1	1.5	2.6	1.3	-0.5	-1.6	-1.0	-1.4
Age at First Birth	0.4	0.5	1.4	1.2	-0.6	-0.7	-0.4	-0.3
Bipolar Disorder (2011)	1.5	1.5	3.7	0.0	0.5	1.9	1.7	0.5
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	0.4	-0.6	-0.7	-0.7	0.4
Coronary Artery Disease (CAD)	1.0	1.2	2.0	0.0	-1.4	1.2	0.8	1.3
Crohns Disease (2012)	0.4	0.6	1.1	1.0	0.6	-0.2	-0.6	1.0
Mean Putamen Volume	0.6	0.7	3.4	0.2	-1.8	-0.1	-0.1	0.3
Fasting Glucose	0.8	1.0	3.6	0.5	-0.6	1.0	0.1	1.9
HbA1C	3.9	4.3	7.8	2.8	1.7	-2.2	-2.2	-1.0
HDL Cholesterol	0.3	0.5	1.5	0.0	-1.2	-0.8	-0.5	-0.5
LDL Cholesterol	0.8	1.3	3.7	-1.5	-0.4	-0.5	0.5	-1.9
Lupus	2.0	3.0	5.5	2.0	0.7	-2.4	-1.7	-1.4
Neuroticism (2016)	0.3	0.4	0.9	-0.9	-1.0	0.4	0.4	0.1
Primary Biliary Cirrhosis	0.8	1.1	5.0	-0.5	2.2	0.2	0.5	0.1
Rheumatoid Arthritis	0.1	0.2	0.6	0.8	0.3	-0.2	-0.3	-0.4
Schizophrenia (2014)	1.1	2.4	4.0	-1.5	2.0	0.6	1.5	-1.8
Triglycerides	0.3	0.5	1.0	0.6	-1.0	0.4	0.1	1.0
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.9	0.7	-0.4	-0.7	-0.9	0.6
Ulcerative Colitis	0.1	0.2	0.8	-0.1	0.9	0.1	0.3	-0.1
Blood Eosinophil Count	0.2	1.6	4.0	-0.5	-0.9	2.0	1.7	0.6
Blood Platelet Count	0.0	0.3	0.9	-0.2	0.9	-0.3	-0.3	-0.6
Blood Red Count	0.1	1.4	4.0	0.9	2.0	-0.1	-0.7	1.3
Blood White Count	0.6	4.6	9.7	0.4	0.9	-3.0	-1.9	-3.1
Heel T-Score	0.1	0.8	2.0	-0.8	0.8	-1.4	-0.8	-0.4
BMI	0.1	0.5	2.4	0.2	0.0	-0.0	-0.5	1.6
Height	1.5	28.9	73.4	-2.0	1.3	7.3	8.6	-3.5
Waist Hip Ratio (WHR)	0.2	0.7	1.8	1.3	0.5	0.6	0.8	-0.7
Systolic Blood Pressure	0.6	3.1	6.7	-0.4	1.0	2.1	2.6	-1.7
Smoking Status	0.0	0.0	0.1	0.0	-0.3	0.2	-0.1	0.1
Allergy or Eczema	1.8	4.8	12.4	-1.0	-0.8	3.5	3.2	0.3
Cardiovascular Disease	0.7	2.3	5.8	-0.6	0.2	2.4	2.2	0.8
Hypothyroidism (self reported)	1.2	2.9	5.7	-2.4	-0.8	1.6	1.0	2.1
Respiratory disease	0.6	1.3	2.8	-0.5	0.7	1.7	1.6	0.3
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.9	0.1	-1.0	-0.6	-1.2	1.4
Lung FEV1/FVC ratio	0.5	2.8	6.9	0.1	0.2	-2.6	-2.6	0.2
Lung FVC	0.1	0.5	1.9	0.1	-0.6	0.0	0.7	-1.4
Neuroticism	0.3	0.7	1.1	0.6	-1.1	-0.8	-1.0	0.4
Chronotype (morning person)	1.6	3.7	7.7	1.9	-1.3	-2.0	-2.8	1.1
Hair Pigment	0.0	0.2	0.4	-0.3	0.5	0.5	0.7	-0.3
Tanning	0.1	1.7	2.2	1.4	1.3	-1.5	-1.4	-0.9
Hand grip strength (left)	0.4	1.0	3.3	0.3	-0.3	0.4	1.2	-1.8
Number of treatments/medications taken	3.3	5.8	11.9	-2.3	0.0	3.5	3.3	0.8
Average weekly spirits intake	0.4	0.5	1.9	-1.4	0.4	0.6	0.4	0.1
Sensitivity / hurt feelings	0.2	0.3	0.9	0.1	0.9	0.4	0.6	-0.2
Frequency of depressed mood in last 2 weeks	1.0	1.4	4.1	2.0	-1.3	-0.8	-0.7	-0.6
Hearing difficulty/problems: Yes	0.6	0.9	2.4	-0.7	-0.1	1.5	1.3	0.0
Relative age of first facial hair	0.2	0.3	0.7	0.7	0.7	-0.3	-0.2	-0.8
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.2	-0.5	1.1	0.3	-0.2	0.9
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.8	-0.5	1.5	0.9	0.3	1.7
Ever had hysterectomy (womb removed)	2.1	2.4	5.2	-0.5	1.7	1.8	2.3	-0.6
Systolic blood pressure, automated reading	0.6	1.8	3.7	-1.1	0.9	1.8	1.9	-0.3
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	3.4	1.2	-0.7	-1.7	-1.8	0.1
Angina	1.0	1.3	2.3	-0.2	-1.5	1.4	1.5	0.2
Medication for hormone replacement therapy	1.5	1.6	2.1	-1.4	1.4	1.4	1.3	0.7
Vitamin and mineral supplements	0.2	0.2	0.4	-0.3	0.6	-0.6	-0.5	-0.2
Supplements: Zinc	0.2	0.3	0.5	-0.5	0.3	0.6	0.7	0.3
Medication: Co-codamol	0.7	0.8	1.3	-0.8	-1.1	0.9	1.1	-0.1
Medication: Metformin	0.5	0.7	2.8	-0.1	-1.7	-0.4	-0.5	0.4
Diabetes (father)	2.8	3.4	6.7	2.6	-0.8	-2.1	-2.3	0.2
Diabetes (mother)	0.1	0.1	0.3	0.0	-0.3	-0.2	0.1	-0.5
Severe depression (siblings)	0.2	0.2	0.2	-0.4	-0.4	-0.5	-0.4	-0.5
Pack years adult smoking proportion	0.5	0.7	1.5	0.3	-0.6	-1.2	-1.2	-0.6
Impedance of leg (right)	0.8	3.8	7.5	-1.2	1.6	2.0	2.7	-1.8
Leg fat-free mass (left)	0.2	0.9	2.2	1.5	-0.9	0.8	0.6	0.6
Trunk fat percentage	0.7	2.7	6.2	-0.6	0.8	2.5	2.5	0.2
Hand grip strength (right)	0.3	0.7	2.2	0.2	-0.4	0.3	1.0	-1.5
Townsend deprivation index at recruitment	0.2	0.3	0.8	0.5	0.9	0.4	0.5	0.3
Current tobacco smoking	1.0	1.6	3.6	1.2	-0.7	-0.8	-1.9	1.4
Average weekly fortified wine intake	2.6	3.1	5.8	-2.4	-0.5	2.1	2.2	-0.3
Maternal smoking around birth	1.2	1.8	3.8	-1.6	0.1	1.5	1.9	-0.6
Fed-up feelings	0.1	0.2	0.4	-0.5	-0.3	-0.6	-0.2	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.6	1.4	-1.6	-0.0	-0.7	1.2
Relative age voice broke	0.3	0.5	1.3	0.3	0.0	1.1	1.1	0.0
Taking other prescription medications	1.0	1.6	3.3	-1.1	0.5	1.8	1.8	0.3
Age when periods started (menarche)	0.4	1.1	2.2	1.5	0.4	-0.5	-1.2	1.2
Bilateral oophorectomy (both ovaries removed)	2.7	3.2	5.7	-1.5	1.8	2.0	2.4	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.4	-0.6	1.8	-1.7	-0.9	-1.3
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.7	-1.3	0.3	0.5	-0.1	1.3
Qualifications: CSEs or equivalent	0.8	1.0	2.5	0.4	-0.6	1.3	0.7	1.6
Serious illness, injury or assault to yourself	0.2	0.3	0.9	0.3	-0.9	0.3	-0.1	0.6
High blood pressure	1.2	3.3	8.5	-0.4	0.5	2.9	2.7	0.7
Hayfever, allergic rhinitis or eczema	1.4	3.0	6.7	-1.1	0.8	2.5	2.6	0.0
Multivitamins +/- minerals	0.1	0.1	0.3	0.6	0.1	0.0	-0.1	0.5
Stomach or abdominal pain in last month	1.3	1.6	5.2	0.0	2.3	-0.9	0.0	-1.5
Supplements: Glucosamine	0.9	1.2	2.8	-0.2	0.8	1.3	0.8	1.7
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.9	-0.7	-0.8	1.3	1.4	-0.2
Medication: Atenolol	1.1	1.4	2.9	0.2	-1.1	1.7	1.0	1.3
Medication: Levothyroxine sodium	2.1	3.6	6.6	-2.1	0.2	2.6	2.2	1.4
Sitting height	0.3	2.4	6.4	0.1	-0.9	2.0	2.5	-0.8
Chronic bronchitis/emphysema (father)	2.0	2.3	6.8	0.8	2.6	0.3	1.2	-1.7
High blood pressure (mother)	0.4	0.6	1.0	1.0	-0.3	-0.5	-0.9	0.9
Body mass index (BMI)	0.2	0.7	2.5	0.6	-0.3	0.0	-0.6	1.6
Impedance of leg (left)	1.0	5.1	9.5	-1.4	1.9	2.1	3.1	-2.4
Leg predicted mass (left)	0.2	0.9	2.2	1.5	-0.9	0.8	0.6	0.6
Trunk fat mass	0.6	2.5	6.4	-0.1	0.4	2.5	2.5	0.1
Waist circumference	0.2	0.9	1.8	0.8	-0.1	1.3	1.3	0.3
Number of incorrect matches in round	0.5	0.9	1.7	-0.8	0.2	1.3	1.3	-0.6
Past tobacco smoking	0.6	1.0	2.5	0.2	0.5	-1.5	-1.6	-0.3
Alcohol usually taken with meals	0.6	1.0	2.4	-1.5	0.4	0.9	1.2	-0.5
Nervous feelings	1.6	3.1	5.6	2.2	-0.4	-2.1	-2.4	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	3.9	0.2	-2.0	-0.1	0.1	-0.3
Hearing difficulty/problems with background noise	0.9	1.5	3.7	-0.7	0.1	1.7	1.9	-0.3
Hair/balding pattern: Pattern 2	0.6	0.8	1.4	-0.4	1.1	1.2	0.9	0.4
Had menopause	0.4	0.5	0.9	0.0	-0.1	1.0	0.8	0.9
Had other major operations	1.0	1.2	2.6	-1.2	0.3	1.3	1.6	0.3
Forced vital capacity (FVC)	0.5	1.8	4.8	-0.0	0.2	1.6	2.2	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	4.3	-0.9	1.6	-1.4	-0.1	-2.1
Ever unenthusiastic/disinterested for a whole week	2.4	2.9	7.9	-2.8	-0.0	1.4	2.1	-0.4
Qualifications: None of the above	1.7	3.6	6.5	-2.2	1.0	2.4	2.6	-0.2
Financial difficulties in last 2 years	1.0	1.4	3.7	1.1	-1.9	-0.7	-1.0	0.6
Mouth/teeth dental problems	1.3	1.9	6.1	0.8	-2.5	-0.2	-0.9	1.5
Heart attack	1.4	1.7	7.2	0.6	-2.7	-0.4	-0.1	-1.0
Allergy	1.3	3.1	6.9	0.7	-1.4	-2.4	-2.6	-0.1
Pain all over the body in last month	0.5	0.5	1.8	-0.8	1.4	-0.2	-0.4	-0.1
Diabetes (self-reported)	0.4	0.6	1.6	-0.8	-0.8	0.3	-0.1	1.3
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	3.3	-0.3	0.9	1.4	1.8	-1.0
Medication: Ramipril	0.7	0.9	2.2	-0.4	-0.8	1.1	1.5	-0.7
Medication: Simvastatin	1.3	1.9	4.1	-1.5	-0.6	1.5	0.7	2.0
Fluid intelligence score	0.4	0.9	3.2	-0.4	1.0	0.3	-0.2	1.8
Illnesses of siblings	0.9	1.3	2.4	-1.3	0.4	1.3	0.7	1.5
Neuroticism score	0.3	0.6	1.6	0.4	0.0	-1.2	-1.1	0.1
Weight	0.2	1.1	2.5	0.7	-0.0	1.6	1.5	0.3
Impedance of arm (right)	0.8	3.7	6.8	-1.3	2.1	2.0	2.6	-1.3
Arm fat percentage (right)	0.3	1.1	2.3	0.0	0.7	1.5	1.1	1.2
Trunk fat-free mass	0.2	1.0	3.0	1.7	-1.0	0.7	0.8	-0.3
Hip circumference	0.2	0.8	1.6	1.1	0.4	0.9	1.3	-0.7
Time employed in main current job	0.1	0.1	0.3	0.0	-0.6	-0.5	-0.3	-0.2
Alcohol intake versus 10 years previously	0.6	0.9	1.8	-0.2	1.4	-1.0	-0.7	-1.1
Father’s age at death	0.5	0.7	2.2	1.1	1.5	-0.1	-0.1	0.0
Worrier / anxious feelings	0.8	1.5	3.1	1.8	-0.7	-0.8	-1.3	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	0.8	-0.5	0.3	0.4	0.1
Falls in the last year	0.4	0.5	2.5	-0.2	1.6	-0.4	-0.3	0.2
Hair/balding pattern: Pattern 3	1.4	2.1	5.7	0.8	-2.4	-1.3	-1.4	0.8
Number of live births	0.3	0.5	1.1	-0.6	1.1	-0.5	-0.7	0.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.2	0.0	-0.2	0.7	1.1	-0.8
Pulse rate	0.1	0.2	0.7	0.0	0.2	0.6	0.3	0.8
Happiness	0.6	0.7	1.4	0.7	0.7	-1.2	-1.1	0.0
Noisy workplace	0.8	1.0	1.8	-1.1	-0.5	0.7	1.3	-1.0
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.8	0.1	1.3	-0.5	-0.3	0.3
Serious illness, injury or assault of a close relative in last 2 years	1.7	2.0	5.8	1.3	2.4	-1.1	-1.0	0.4
Mouth/teeth dental problems: Dentures	0.5	0.9	2.3	-1.1	0.0	0.4	0.9	-1.5
Asthma	1.3	2.6	4.8	-1.3	1.5	2.0	2.2	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	3.2	-1.8	-0.2	0.6	1.0	-0.5
Medication: Cholesterol lowering	1.3	1.9	2.9	-1.5	-1.1	1.7	1.6	0.9
Depression (self-reported)	1.3	1.5	2.4	0.9	-1.5	-1.1	-1.5	1.1
Medication: Lansoprazole	0.3	0.3	1.0	1.0	-0.0	0.0	0.3	-0.7
Prospective memory result	0.2	0.3	0.8	0.3	0.2	-0.5	-0.9	0.5
Lung cancer (father)	2.0	2.3	4.4	-1.6	1.0	1.8	2.1	-0.6
Illnesses of mother	0.2	0.2	0.8	-0.9	0.3	-0.3	-0.1	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	3.9	0.4	-0.2	0.1	1.0	-2.0
Pulse wave Arterial Stiffness index	1.2	1.4	2.9	-1.7	0.8	1.2	1.4	0.1
Impedance of arm (left)	0.7	3.3	7.0	-1.4	1.4	1.9	2.6	-1.4
Arm fat mass (right)	0.2	0.7	1.6	0.2	-0.0	1.3	0.9	1.0
Trunk predicted mass	0.2	1.0	3.0	1.7	-1.1	0.6	0.7	-0.3
Standing height	0.8	7.9	19.7	0.5	0.6	3.2	4.4	-3.1
Length of working week for main job	1.0	1.1	3.0	1.7	-1.3	-0.8	-0.5	-0.2
Exposure to tobacco smoke at home	1.3	1.5	2.7	0.9	-1.3	-1.0	-1.7	1.1
Breastfed as a baby	1.4	1.8	5.9	-0.6	-2.4	1.2	1.1	0.3
Tense / ‘highly strung’	0.5	0.8	3.4	-0.3	-0.3	0.1	0.8	-1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.2	-0.8	-0.7	1.8	1.6	0.5
Hair/balding pattern: Pattern 4	0.1	0.1	0.3	0.3	0.5	0.4	0.1	0.3
Birth weight of first child	0.3	0.6	2.3	-0.2	0.4	0.7	0.0	1.5
Peak expiratory flow (PEF)	0.2	0.6	1.6	-0.4	-0.1	0.9	1.3	-0.3
Pulse wave reflection index	1.1	1.4	3.2	-1.5	0.8	0.1	1.0	-1.8
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.4	-1.2	-1.0	0.2	0.0	0.3
Loud music exposure frequency	0.5	0.6	1.3	-0.2	-0.1	0.5	1.1	-1.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.9	-0.0	0.6	-0.8	-0.9	0.7
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.3	-0.1	1.5	0.4	0.1	0.9
Blood clot in the leg (DVT)	1.6	2.0	3.0	1.0	1.6	-1.7	-1.7	0.9
Medication: Paracetamol	2.3	3.8	8.2	-2.9	-0.1	2.1	2.5	-0.6
Headache pain in last month	0.5	0.9	2.9	-0.2	1.1	-0.0	0.7	-1.7
Medication for cholesterol, blood pressure or diabetes	2.0	3.2	6.0	1.7	1.0	-2.4	-2.3	-1.1
Glaucoma (self-reported)	0.3	0.4	1.1	0.7	0.4	0.3	-0.4	1.1
Gout (self-reported)	0.1	0.1	0.3	0.5	-0.3	0.1	-0.1	0.1
Hypothyroidism/myxoedema (self-reported)	2.7	5.3	9.1	-3.0	0.0	2.8	2.3	2.0
Medication: Amlodipine	1.4	2.0	4.7	-0.4	-0.3	2.2	1.5	1.6
Medication: Ventolin 100micrograms inhaler	0.8	1.1	4.1	0.8	2.0	0.2	0.5	-0.5
Birth weight	0.2	0.3	0.9	-0.3	0.0	0.8	0.3	0.9
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.7	-0.3	0.3	1.3	1.1	0.0
High blood pressure (siblings)	0.2	0.3	0.4	0.6	0.4	-0.5	-0.3	-0.6
Forced vital capacity (FVC), Best measure	0.6	2.3	5.0	0.2	-0.2	1.4	2.2	-2.1
Body fat percentage	0.5	2.0	4.9	-0.3	0.6	2.2	2.1	0.4
Leg fat percentage (right)	0.3	1.2	3.1	0.2	0.2	1.8	1.4	0.8
Arm fat-free mass (right)	0.2	1.0	3.1	1.8	-0.9	0.5	0.7	-0.5
Exposure to tobacco smoke outside home	0.4	0.6	1.4	-0.5	-0.5	0.8	1.2	-0.5
Comparative body size at age 10	1.1	3.0	7.9	0.7	-0.3	-2.1	-2.8	1.4
Number of full brothers	0.9	1.1	2.9	0.6	0.6	1.7	1.2	0.5
Worry too long after embarrassment	0.1	0.1	0.6	-0.0	-0.8	0.1	-0.1	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.8	0.1	-0.4	0.4	0.9	-0.7
Wheeze or whistling in the chest in last year	0.5	1.0	2.6	0.2	1.1	1.0	1.6	0.1
Number of children fathered	0.6	0.7	2.2	0.1	-1.5	-0.0	0.5	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.1	-0.6	-1.5	0.8	0.9	-0.4
Age at first live birth	0.5	0.9	1.4	1.2	-1.1	-0.9	-1.0	-0.5
Pulse wave peak to peak time	1.2	1.4	3.4	1.9	-0.9	-1.0	-1.3	-0.0
Health satisfaction	0.7	0.9	2.1	0.4	-0.1	1.4	1.3	0.7
Shortness of breath walking on level ground	0.8	0.9	2.2	-0.6	-0.8	1.2	1.5	-0.3
Qualifications: College or University degree	0.2	0.6	1.3	-0.9	0.1	0.8	0.6	1.1
Eye problems/disorders: None of the above	1.0	1.1	2.7	-1.6	1.2	0.9	0.7	0.5
Mouth/teeth dental problems: Loose teeth	1.7	2.0	3.8	-1.4	0.1	1.7	1.1	2.0
Emphysema/chronic bronchitis	0.2	0.2	0.5	0.7	0.5	0.3	0.1	0.1
Medication for pain relief, constipation, heartburn	2.0	3.4	9.0	3.0	-0.1	-1.9	-2.1	0.4
Neck or shoulder pain in last month	0.0	0.0	0.1	-0.2	0.0	-0.1	0.2	-0.2
Medication: Blood pressure	0.5	1.0	1.9	-0.2	-0.9	1.4	1.3	0.6
Angina (self-reported)	1.1	1.4	2.7	-0.2	-1.5	1.4	1.6	-0.2
Migraine (self-reported)	0.1	0.1	0.4	0.0	0.2	-0.4	-0.6	-0.1
Medication: Ibuprofen	0.6	0.7	1.0	-1.0	-0.7	0.6	1.0	-0.6
Medication: Allopurinol	0.2	0.2	0.8	0.6	-0.0	0.0	0.2	-0.9
Medication: Omeprazole	1.3	1.5	2.8	-1.7	0.9	1.5	1.2	0.2
Medication: Seretide 50 evohaler	0.7	0.8	3.0	1.7	0.0	-0.4	-0.6	0.6
Mean time to correctly identify matches	0.0	0.1	0.3	-0.3	-0.5	-0.0	-0.2	-0.0
Heart disease (mother)	1.3	1.6	2.8	-0.9	-1.3	1.4	1.7	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.6	-0.8	-0.4	1.5	1.6	-0.4
Whole body fat mass	0.4	1.6	4.1	0.1	0.1	2.0	2.0	0.1
Leg fat mass (right)	0.2	0.9	2.3	0.6	-0.0	1.5	1.3	0.6
Arm predicted mass (right)	0.2	0.9	2.3	1.5	-1.3	0.3	0.5	-0.5
Pulse rate, automated reading	0.3	1.0	2.4	0.5	-0.5	-1.1	-1.5	0.9
Alcohol intake frequency.	0.5	1.3	3.8	1.2	-1.9	-0.7	-0.8	-0.3
Comparative height size at age 10	1.1	5.8	13.8	0.2	0.2	2.4	3.7	-3.1
Number of full sisters	0.3	0.3	0.7	-0.1	0.6	-0.8	-0.7	0.2
Suffer from ‘nerves’	3.4	5.4	10.5	2.6	0.5	-3.0	-3.2	0.6
Overall health rating	0.4	0.9	2.2	1.5	1.0	0.4	-0.0	1.0
Chest pain or discomfort	0.1	0.1	0.4	0.7	0.1	0.3	0.4	0.1
Had major operations	1.2	1.4	3.1	-1.8	0.4	0.8	1.3	-1.2
Age at last live birth	0.6	0.8	1.4	0.3	-1.2	-0.7	-1.2	0.8
Family relationship satisfaction	0.9	1.1	3.6	0.2	-1.9	-1.0	-0.9	0.1
Leg pain on walking	0.2	0.3	0.7	-0.7	-0.2	-0.5	-0.1	-0.8
Qualifications: NVQ or HND or HNC or equivalent	2.2	2.7	5.8	1.4	0.8	-2.4	-1.8	-1.4
Commuting to job workplace: Car/motor vehicle	0.5	0.5	0.9	0.2	0.9	0.9	0.7	0.6
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.0	-1.0	1.0	0.2	0.7	-0.6
Medication: Aspirin	1.3	1.7	3.2	-0.9	-1.8	1.4	1.6	-0.4
Supplements: Vitamin C	0.6	0.7	3.6	0.2	-1.9	0.2	0.1	-0.0
Knee pain experienced in last month	1.4	2.2	6.1	-1.0	2.5	1.1	1.5	-0.9
Hypertension (Self-reported)	1.2	3.3	8.4	-0.4	0.3	2.9	2.6	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	5.2	6.1	14.8	-2.0	0.1	3.8	3.2	1.1
Illnesses of father: Heart disease	0.7	0.9	3.2	1.0	0.6	0.4	-0.1	1.8
Illnesses of siblings: Diabetes	1.3	1.6	2.9	1.4	-0.6	-1.7	-1.7	0.2
Smoking status: Previous	1.3	2.0	5.5	-0.7	-0.1	2.0	2.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.6	9.2	1.3	-2.0	0.2	1.7	-3.0
Whole body fat-free mass	0.2	0.9	2.7	1.6	-1.0	0.7	0.7	0.0
Leg fat-free mass (right)	0.1	0.8	2.2	1.5	-0.9	0.6	0.5	0.3
Arm fat percentage (left)	0.2	0.8	1.6	0.2	0.4	1.3	0.9	1.2
Average weekly red wine intake	0.5	0.7	2.2	-1.5	0.3	-0.3	0.1	-1.0
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.5	-1.5	1.6	0.7	0.2	0.1
Mood swings	0.1	0.1	0.5	-0.2	-0.0	0.4	0.7	-0.1
Loneliness, isolation	0.3	0.4	2.0	1.4	0.1	-0.1	-0.2	0.2
Long-standing illness, disability or infirmity	0.3	0.5	0.8	-0.9	0.6	0.8	0.6	0.3
Ever had bowel cancer screening	0.3	0.4	1.1	-1.1	0.7	0.0	0.3	-0.3
Diabetes diagnosed by doctor	0.3	0.5	1.5	-0.4	-0.9	0.3	-0.2	1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.3	-1.4	0.4	0.5	1.5	-1.5
Friendships satisfaction	0.4	0.5	1.6	0.0	0.0	-1.3	-0.9	-0.5
Qualifications: nursing, teaching	0.5	0.8	1.9	0.5	-0.7	-1.4	-1.0	-0.4
Commuting to job workplace: Walk	0.3	0.4	0.9	-1.0	0.6	0.5	0.5	-0.3
Eye problems/disorders: Cataract	1.4	1.6	5.2	1.5	-2.3	-0.6	-0.4	0.2
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	4.8	0.9	2.2	0.3	-0.3	1.4
Medication for cholesterol	0.7	1.1	3.4	-0.6	-1.0	-0.8	0.2	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	0.7	0.1	0.0	-0.4	0.5
Back pain experienced in last month	0.6	0.9	2.3	0.2	-1.5	-0.6	-1.1	0.9
Mineral and other dietary supplements	0.3	0.4	0.7	0.1	-0.5	-0.8	-0.9	-0.5
Breast cancer (self-reported)	1.8	2.1	6.6	-2.6	-0.6	1.3	1.4	0.3
Asthma (self-reported)	1.4	2.8	5.2	-1.4	1.4	2.2	2.3	0.4
Osteoporosis (self-reported)	1.5	1.9	7.8	0.3	-2.8	0.5	0.8	-0.9
Osteoarthritis (self-reported)	0.7	1.0	2.0	-0.7	1.3	0.3	0.8	-1.4
Medication: Aspirin	1.0	1.3	3.6	-0.6	-1.9	1.1	1.0	0.2
Medication: Gliclazide	0.4	0.5	1.2	-0.4	-0.9	0.3	-0.2	1.1
Illnesses of father: None of the above (group 1)	0.4	0.4	0.9	-0.9	-0.4	-0.1	-0.7	0.8
Smoking status: Current	1.5	2.4	6.1	1.5	-0.8	-1.5	-2.5	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.1	-0.9	0.5	-0.1	0.4	-1.1
Whole body water mass	0.2	1.0	2.7	1.6	-1.1	0.7	0.7	0.0
Leg predicted mass (right)	0.1	0.8	2.2	1.5	-1.0	0.6	0.5	0.4
Arm fat mass (left)	0.2	0.7	1.4	0.4	-0.0	1.2	0.9	1.0
Number of self-reported non-cancer illnesses	3.1	5.4	11.3	-2.1	0.4	3.4	3.2	0.7
Average weekly champagne plus white wine intake	0.6	0.9	3.2	0.7	-1.8	-0.4	-0.6	0.4
Miserableness	0.3	0.5	1.2	-1.1	-0.4	0.1	0.7	-0.7
Guilty feelings	0.4	0.6	2.2	-0.5	0.3	-0.1	-0.7	1.5
Wears glasses or contact lenses	0.8	1.0	2.2	-0.3	-0.3	1.5	1.0	1.2
Ever taken oral contraceptive pill	0.5	0.5	1.7	0.3	0.9	0.3	-0.1	1.3
Hearing aid user	2.4	2.7	6.2	1.5	0.3	-1.4	-2.5	1.7
Mother’s age at death	0.3	0.3	0.6	0.7	0.1	-0.7	-0.8	0.2
Financial situation satisfaction	0.9	1.1	4.2	2.1	-0.5	-0.2	-0.7	0.9
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.1	1.0	0.2	-1.0	-0.7	-0.7
Commuting to job workplace: Public transport	0.6	0.7	1.1	-0.9	0.4	1.1	1.0	0.1
Eye problems/disorders: Glaucoma	0.2	0.3	0.6	0.6	0.1	-0.6	-0.7	-0.2
Medication: Blood pressure	0.7	1.3	2.9	0.3	0.9	1.5	0.7	1.7
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.4	0.6	-0.0	-0.6	-0.4	-0.3
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.3	-0.6	0.2	1.1	1.5	-0.1
High cholesterol (Self-reported)	1.4	2.6	5.3	-2.3	0.4	1.9	1.6	1.0
Medication: Bendroflumethiazide	1.4	2.1	4.1	-1.3	-0.9	2.0	1.7	0.9
Medication: Paracetamol	1.9	3.0	6.5	-1.8	-0.6	2.0	2.5	-0.8
Medication: Lisinopril	1.4	1.9	3.5	-0.7	1.9	1.6	1.6	-0.1
Medication: Atorvastatin	0.4	0.5	1.3	0.7	-1.2	-0.5	-0.4	-0.2
Illnesses of father: High blood pressure	0.8	1.0	2.4	1.4	1.5	-0.4	-0.1	-0.7
Alcohol drinker status: Never	0.7	0.8	2.1	1.1	-1.4	-0.6	-0.5	-0.1
Ever smoked	0.1	0.2	0.4	0.4	-0.6	0.2	0.2	0.6
Basal metabolic rate	0.2	1.0	2.2	1.5	-0.9	1.0	1.0	0.1
Leg fat percentage (left)	0.3	0.9	2.3	0.4	0.4	1.5	1.4	0.4
Arm fat-free mass (left)	0.2	0.8	1.6	1.2	-0.8	0.9	1.0	-0.1
Number of operations (self-reported)	2.4	3.6	6.3	-1.9	1.8	1.5	2.5	-1.6
Average weekly beer plus cider intake	1.6	2.3	4.1	1.4	0.4	-1.4	-2.0	1.8
Irritability	0.8	1.4	3.7	-0.2	0.0	-1.9	-1.4	-1.2
Risk taking	0.1	0.1	0.6	0.1	-0.8	-0.1	-0.2	0.2
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.5	-1.9	0.5	0.6	1.3	-1.2
Fractured/broken bones in last 5 years	0.8	1.0	2.5	-1.0	1.1	-0.7	0.1	-1.6
Age started oral contraceptive pill	1.0	1.3	2.6	1.0	0.7	-1.6	-1.5	-0.5
Diastolic blood pressure, automated reading	0.5	1.5	3.8	0.3	0.6	1.8	2.0	0.1
Ever depressed for a whole week	1.8	2.3	4.7	-2.1	0.1	1.5	2.2	-0.4
Unable to work because of sickness or disability	0.5	0.7	1.8	1.1	1.4	-0.3	0.0	-0.2
Commuting to job workplace: Cycle	0.3	0.4	0.9	-0.2	1.0	-0.4	0.1	-0.8
Myopia	1.1	1.5	2.3	-1.4	1.5	1.4	1.1	0.5
Vascular/heart problems diagnosed by doctor	1.3	3.5	9.2	0.3	0.7	-3.0	-2.5	-1.2
Cholesterol lowering medication	0.2	0.3	0.9	0.3	-1.0	-0.2	-0.6	0.6
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	3.1	-1.7	1.2	1.0	1.1	-0.5
Pain experienced in last month	0.7	1.1	2.3	1.5	-1.1	-0.8	-1.2	0.5
Supplements: Calcium	1.4	1.6	3.2	-1.8	0.1	1.0	1.5	-1.1
Basal cell carcinoma (self-reported)	1.0	1.2	5.5	0.6	-2.4	-0.4	-0.2	0.0
Heart attack/myocardial infarction (self-reported)	1.5	1.9	7.9	0.6	-2.8	-0.5	-0.2	-1.0
Deep venous thrombosis (DVT) (self-reported)	1.4	1.7	3.1	0.8	1.8	-1.5	-1.5	0.7
Heart disease (siblings)	0.6	0.7	2.4	-0.7	-0.6	-0.1	0.6	-1.6
Alcohol drinker status: Previous	0.5	0.6	2.1	-0.1	-1.4	0.3	0.3	-0.9
Pack years of smoking	0.5	0.8	1.4	0.7	-0.4	-1.2	-1.0	-0.9
Impedance of whole body	1.0	4.9	9.7	-1.7	1.8	2.3	3.1	-1.9
Leg fat mass (left)	0.2	0.8	2.0	0.7	0.2	1.4	1.2	0.4
Arm predicted mass (left)	0.1	0.7	1.6	1.3	-0.8	0.7	0.8	-0.4