Hub : Genes

MCMBP

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.106	0.031	6.5e-06	0.007	0.053	0.052	0.053	0.025	0.044	4.6e-07	5.7e-07	4.8e-07	0.00046
2	GTEx	Cells Transformed fibroblasts	0.137	0.053	3.4e-03	-0.002	NA	-0.001	NA	-0.001	0.450	NA	4.1e-01	NA	0.38000
3	GTEx	Heart Atrial Appendage	0.217	0.073	1.3e-03	-0.003	NA	0.005	NA	0.000	0.460	NA	1.9e-01	NA	0.30000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.2	0.3	0.5	0.6	0.7	-0.1
Bipolar Disorder or Schizophrenia	0.3	0.7	1.4	0.6	1.2	-0.6
Depressed Affect (Nagel 2018)	2.9	6.1	11.6	0.8	-2.4	-3.4
Depression (Nagel 2018)	0.6	0.9	2.4	0.3	-1.6	-0.5
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.0	-0.9	-1.0	-0.9
Neuroticism (Nagel 2018)	3.5	8.2	12.7	2.0	-2.8	-3.6
Schizophrenia (2018)	0.2	0.3	0.5	0.4	0.7	-0.6
Schizophrenia vs Biploar Disorder	0.8	1.0	2.2	-0.9	-0.0	1.5
Worry (Nagel 2018)	1.2	2.6	3.5	1.9	-1.4	-1.5
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	-0.2	-0.2	-0.1
Alzheimer’s Disease (in father)	1.2	1.3	3.5	-1.9	-0.3	0.5
Alzheimer’s Disease (including proxy)	0.3	0.4	0.8	-0.9	-0.5	0.4
Crohns Disease (2017)	0.5	1.2	3.3	1.8	-0.5	-0.1
Irritable Bowel Disease (IBD)	0.2	0.5	0.8	0.9	-0.1	0.9
Ulcerative Colitis (UC)	0.3	0.5	1.0	-0.7	0.3	1.0
Major Depression (MDD)	1.5	1.9	4.1	0.7	2.0	-1.0
Reaction Time	0.3	0.6	1.3	1.2	-0.3	0.7
Verbal and Numeric Reasoning (VNR)	0.6	1.5	2.5	-0.8	-1.1	-1.6
Breast Cancer	1.3	3.2	7.2	2.7	1.3	-0.8
Ovarian Cancer	0.6	0.8	2.1	-1.4	-0.3	0.4
Prostate Cancer	0.5	0.6	1.1	-1.1	0.9	0.1
Age at First Birth	1.7	2.5	3.0	1.6	-1.7	1.4
Bipolar Disorder (2011)	0.2	0.2	0.5	0.7	0.2	-0.2
Body Mass Index (BMI) (2010)	3.2	4.4	9.2	-3.0	1.9	0.4
Coronary Artery Disease (CAD)	0.6	0.8	1.8	0.5	-1.3	-0.6
Crohns Disease (2012)	0.5	0.9	1.3	1.2	-0.2	1.1
Mean Putamen Volume	2.4	2.8	3.6	-1.9	1.9	1.1
Fasting Glucose	1.5	1.8	3.6	-0.5	-1.3	-1.9
HbA1C	2.0	2.2	6.2	0.5	0.4	-2.5
HDL Cholesterol	0.2	0.3	0.5	0.7	-0.4	0.5
LDL Cholesterol	1.1	1.8	4.1	0.1	1.2	-2.0
Lupus	0.7	1.0	1.6	-1.3	0.9	0.7
Neuroticism (2016)	0.5	0.7	1.6	0.6	-1.3	-0.3
Primary Biliary Cirrhosis	0.2	0.3	0.4	0.6	-0.5	0.6
Rheumatoid Arthritis	2.4	3.4	5.0	-2.0	1.0	-2.2
Schizophrenia (2014)	0.2	0.5	1.0	0.4	0.6	-1.0
Triglycerides	0.7	1.2	2.2	-0.6	1.0	-1.5
Type 2 Diabetes (T2D) (2012)	0.6	0.6	1.1	-0.6	-0.7	-1.1
Ulcerative Colitis	0.8	1.2	2.3	-0.4	-1.0	1.5
Blood Eosinophil Count	0.1	0.7	1.7	-0.1	-1.3	-0.6
Blood Platelet Count	0.1	0.8	1.5	-0.8	-0.3	1.2
Blood Red Count	0.0	0.4	0.9	-0.3	-0.9	0.3
Blood White Count	0.3	2.5	5.2	2.3	-1.5	0.3
Heel T-Score	0.7	5.2	9.6	0.1	-2.4	-3.1
BMI	0.5	2.7	4.8	-1.4	2.2	1.1
Height	2.8	54.0	93.5	-8.0	2.1	9.7
Waist Hip Ratio (WHR)	0.4	1.7	4.8	2.2	0.5	-0.0
Systolic Blood Pressure	1.3	6.6	10.8	-3.3	-2.3	-1.9
Smoking Status	0.3	0.7	1.7	0.6	-0.1	-1.3
Allergy or Eczema	1.8	4.7	9.8	-3.1	-0.1	2.0
Cardiovascular Disease	0.0	0.1	0.2	-0.0	-0.5	-0.2
Hypothyroidism (self reported)	0.7	1.7	2.0	1.1	-1.4	1.4
Respiratory disease	0.9	2.1	3.9	1.5	-2.0	-0.3
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.2	1.1	-0.3	-0.9
Lung FEV1/FVC ratio	1.2	6.1	12.4	-3.5	1.9	-1.5
Lung FVC	0.8	3.9	9.0	-3.0	-0.6	-1.5
Neuroticism	1.5	3.6	6.2	1.3	-1.6	-2.5
Chronotype (morning person)	0.8	1.9	3.6	-0.9	-1.1	1.9
Hair Pigment	0.1	1.4	2.6	0.0	-1.3	-1.6
Tanning	0.2	1.9	2.2	1.1	-1.5	-1.5
Hand grip strength (left)	0.8	2.1	4.7	-2.2	-0.3	1.2
Number of treatments/medications taken	0.4	0.7	1.5	1.2	0.0	-0.9
Average weekly spirits intake	1.7	2.1	3.7	1.6	0.5	-1.9
Sensitivity / hurt feelings	0.8	1.4	2.7	1.1	-1.6	-0.6
Frequency of depressed mood in last 2 weeks	1.0	1.4	2.1	0.3	-1.5	-1.4
Hearing difficulty/problems: Yes	0.5	0.7	0.9	1.0	0.7	-0.8
Relative age of first facial hair	0.2	0.4	1.0	0.5	-1.0	0.1
Other serious medical condition/disability diagnosed by doctor	1.6	2.0	3.3	1.8	0.5	1.6
Ever used hormone-replacement therapy (HRT)	2.4	3.1	7.7	0.5	1.1	-2.8
Ever had hysterectomy (womb removed)	0.3	0.4	1.0	0.3	-1.0	-0.4
Systolic blood pressure, automated reading	0.1	0.3	0.9	-0.9	0.2	-0.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.8	-0.6	1.4	-0.7
Angina	0.9	1.1	2.0	1.4	-1.0	0.6
Medication for hormone replacement therapy	0.8	0.9	2.1	-0.2	0.7	-1.4
Vitamin and mineral supplements	4.1	5.6	14.3	1.5	-3.8	0.4
Supplements: Zinc	0.3	0.3	0.7	-0.1	0.5	0.8
Medication: Co-codamol	1.9	2.2	4.3	0.5	-1.5	-2.1
Medication: Metformin	1.1	1.5	4.5	2.1	-0.0	0.1
Diabetes (father)	1.1	1.4	3.8	-1.9	0.1	0.7
Diabetes (mother)	1.2	1.5	4.4	0.1	-2.1	-0.4
Severe depression (siblings)	2.0	2.2	3.9	0.7	1.5	-2.0
Pack years adult smoking proportion	0.3	0.5	0.8	0.8	0.9	-0.2
Impedance of leg (right)	1.6	7.7	14.7	2.9	-0.0	-3.8
Leg fat-free mass (left)	1.8	9.6	13.7	-3.7	1.3	3.7
Trunk fat percentage	0.4	1.7	3.6	-1.1	1.9	-0.5
Hand grip strength (right)	0.5	1.3	2.0	-1.3	-0.4	1.4
Townsend deprivation index at recruitment	0.7	1.0	2.2	-0.2	-0.9	-1.5
Current tobacco smoking	0.1	0.2	0.3	0.6	0.1	-0.4
Average weekly fortified wine intake	0.2	0.2	0.4	-0.4	0.6	0.3
Maternal smoking around birth	0.4	0.5	1.2	0.1	-0.7	-1.1
Fed-up feelings	3.0	5.4	7.9	1.0	-2.8	-2.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.1	-0.6	-0.4	-1.1
Relative age voice broke	0.5	0.7	1.3	-0.2	-1.2	0.9
Taking other prescription medications	0.9	1.4	3.9	2.0	0.1	-0.5
Age when periods started (menarche)	0.9	2.1	4.5	2.1	-0.9	-1.1
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.7	0.0	-1.3	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.2	-0.4	-0.5	-0.4
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	4.5	-0.1	1.3	-2.1
Qualifications: CSEs or equivalent	0.0	0.0	0.0	0.2	0.2	0.1
Serious illness, injury or assault to yourself	0.5	0.6	1.0	0.7	0.6	-1.0
High blood pressure	0.2	0.6	0.6	-0.7	0.8	0.8
Hayfever, allergic rhinitis or eczema	1.4	3.0	6.1	-2.5	1.0	1.4
Multivitamins +/- minerals	3.0	3.8	9.4	-1.4	3.1	0.0
Stomach or abdominal pain in last month	0.5	0.7	2.0	0.2	0.0	-1.4
Supplements: Glucosamine	4.2	5.5	12.2	-1.9	3.5	0.7
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	0.9	0.9	0.6	-0.2
Medication: Atenolol	1.2	1.5	2.9	-0.4	1.7	1.2
Medication: Levothyroxine sodium	0.9	1.5	3.1	1.1	-0.5	1.8
Sitting height	1.1	8.0	13.9	-3.2	-0.2	3.7
Chronic bronchitis/emphysema (father)	0.7	0.8	2.0	-0.6	-0.1	-1.4
High blood pressure (mother)	0.4	0.5	0.8	0.6	-0.9	-0.6
Body mass index (BMI)	0.2	0.8	1.8	-0.7	1.4	-0.4
Impedance of leg (left)	1.7	8.2	17.0	2.7	-0.4	-4.1
Leg predicted mass (left)	1.9	9.9	14.6	-3.7	1.3	3.8
Trunk fat mass	0.5	2.2	3.3	-1.7	1.8	0.7
Waist circumference	0.5	1.7	3.2	-0.0	1.8	1.4
Number of incorrect matches in round	0.6	1.0	1.7	0.5	1.3	1.0
Past tobacco smoking	0.0	0.1	0.2	-0.5	-0.0	0.1
Alcohol usually taken with meals	3.3	5.4	14.1	-3.8	1.4	-0.4
Nervous feelings	0.6	1.1	1.6	1.2	0.6	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.8	0.2	-1.1	-1.3
Hearing difficulty/problems with background noise	0.4	0.6	1.4	-0.1	-0.6	-1.2
Hair/balding pattern: Pattern 2	1.1	1.4	3.8	0.5	-2.0	-0.3
Had menopause	0.8	1.0	1.1	1.0	0.8	1.1
Had other major operations	1.4	1.7	3.1	-1.4	-1.8	-0.3
Forced vital capacity (FVC)	1.1	4.3	11.2	-3.4	-1.2	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.5	-0.7	-0.5	-0.2
Ever unenthusiastic/disinterested for a whole week	1.8	2.3	5.5	0.1	1.1	-2.4
Qualifications: None of the above	0.8	1.7	4.3	2.1	-0.4	-0.7
Financial difficulties in last 2 years	1.4	1.8	2.8	1.7	-0.3	-1.6
Mouth/teeth dental problems	0.7	1.1	1.7	0.9	0.9	-1.3
Heart attack	0.2	0.3	0.5	0.0	0.7	0.7
Allergy	0.5	1.1	1.6	1.2	-0.6	-1.3
Pain all over the body in last month	0.6	0.6	0.9	0.8	-1.0	-0.5
Diabetes (self-reported)	1.0	1.6	3.6	1.9	-0.8	-0.7
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.0	0.1	1.0	0.8
Medication: Ramipril	0.3	0.4	1.1	1.1	0.1	0.3
Medication: Simvastatin	1.1	1.6	4.3	2.1	0.4	0.7
Fluid intelligence score	0.3	0.5	1.6	0.1	0.2	-1.3
Illnesses of siblings	0.3	0.5	0.7	0.3	0.9	0.7
Neuroticism score	2.0	4.1	6.9	0.8	-2.2	-2.6
Weight	0.9	4.2	5.8	-2.4	2.0	1.7
Impedance of arm (right)	0.0	0.2	0.6	-0.8	-0.0	-0.1
Arm fat percentage (right)	0.4	1.4	1.9	-1.3	1.4	-0.9
Trunk fat-free mass	1.6	9.3	15.4	-3.2	1.6	3.9
Hip circumference	0.7	3.0	4.3	-2.1	1.6	1.5
Time employed in main current job	4.5	5.2	8.4	2.9	-1.7	2.0
Alcohol intake versus 10 years previously	0.1	0.2	0.4	0.3	0.6	0.1
Father’s age at death	0.5	0.7	2.0	-0.1	0.2	-1.4
Worrier / anxious feelings	0.6	1.1	2.0	-0.5	-1.4	-1.0
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.2	6.5	2.5	-1.0	-1.4
Falls in the last year	0.9	1.2	3.3	0.5	0.2	-1.8
Hair/balding pattern: Pattern 3	0.8	1.2	3.2	-0.5	0.3	-1.8
Number of live births	1.9	2.8	3.9	-1.6	-1.3	2.0
Forced expiratory volume in 1-second (FEV1)	1.8	6.2	18.5	-4.3	-0.2	-0.2
Pulse rate	0.8	1.4	1.8	-1.2	0.8	1.4
Happiness	0.4	0.4	0.9	-0.4	0.5	-0.9
Noisy workplace	0.1	0.2	0.4	-0.0	0.7	-0.2
Qualifications: A levels/AS levels or equivalent	1.5	3.4	4.4	-1.8	-1.6	-2.1
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.1	3.8	0.3	-1.5	-1.9
Mouth/teeth dental problems: Dentures	0.3	0.5	1.1	-1.1	-0.4	0.5
Asthma	0.0	0.1	0.2	0.4	-0.3	-0.1
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	3.6	0.2	-1.8	-1.9
Medication: Cholesterol lowering	1.0	1.6	3.1	1.8	-1.2	0.3
Depression (self-reported)	0.6	0.8	1.9	0.6	1.4	0.1
Medication: Lansoprazole	0.5	0.6	1.5	1.2	0.4	-0.2
Prospective memory result	1.2	1.5	4.1	-0.6	-0.1	-2.0
Lung cancer (father)	2.1	2.4	5.0	1.1	-2.2	-1.0
Illnesses of mother	1.0	1.2	3.1	-0.4	0.6	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	7.1	20.3	-4.5	-0.4	-0.9
Pulse wave Arterial Stiffness index	1.1	1.3	2.5	0.8	0.9	-1.6
Impedance of arm (left)	0.1	0.5	0.7	-0.8	-0.9	-0.4
Arm fat mass (right)	0.4	1.8	2.9	-1.6	1.7	0.0
Trunk predicted mass	1.6	9.0	14.7	-3.1	1.7	3.8
Standing height	1.4	14.3	24.4	-4.0	1.6	4.9
Length of working week for main job	0.2	0.3	0.4	0.7	-0.4	-0.4
Exposure to tobacco smoke at home	0.8	0.8	1.2	1.1	-0.4	-1.1
Breastfed as a baby	0.7	0.8	1.8	1.3	-0.7	0.4
Tense / ‘highly strung’	0.7	1.2	2.2	1.2	-1.5	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	3.1	1.7	0.8	-1.8
Hair/balding pattern: Pattern 4	1.1	2.8	4.3	0.7	2.1	1.9
Birth weight of first child	0.2	0.3	0.6	-0.2	-0.5	0.8
Peak expiratory flow (PEF)	1.4	3.4	9.9	-3.1	0.1	-0.5
Pulse wave reflection index	2.4	3.0	5.6	1.0	-1.5	-2.4
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.7	0.6	-0.7	-1.3
Loud music exposure frequency	1.4	1.6	4.6	-0.0	0.2	-2.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	0.3	-0.5	-0.6
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	2.4	0.5	-0.5	1.5
Blood clot in the leg (DVT)	0.5	0.6	1.0	-0.8	1.0	0.3
Medication: Paracetamol	1.1	1.8	5.2	2.3	-0.2	0.2
Headache pain in last month	0.9	1.5	2.5	-1.1	-0.9	-1.6
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	4.0	-2.0	0.4	-0.4
Glaucoma (self-reported)	0.1	0.2	0.3	0.5	0.1	0.4
Gout (self-reported)	0.9	1.2	3.5	1.9	0.4	0.0
Hypothyroidism/myxoedema (self-reported)	0.8	1.7	2.8	1.7	-0.9	1.2
Medication: Amlodipine	0.0	0.1	0.1	0.3	0.1	0.3
Medication: Ventolin 100micrograms inhaler	1.1	1.5	2.0	1.4	-1.0	1.2
Birth weight	0.2	0.4	0.5	-0.7	0.7	-0.2
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.1	-1.1	-1.1	0.4
High blood pressure (siblings)	0.2	0.3	0.7	-0.4	-0.3	0.8
Forced vital capacity (FVC), Best measure	1.2	4.4	12.0	-3.5	-1.1	0.3
Body fat percentage	0.4	1.7	3.0	-0.8	1.7	-1.2
Leg fat percentage (right)	0.8	3.0	6.5	1.0	1.3	-2.6
Arm fat-free mass (right)	0.8	4.1	6.9	-2.0	1.2	2.6
Exposure to tobacco smoke outside home	1.1	1.5	2.4	-1.3	-0.6	-1.5
Comparative body size at age 10	2.2	6.1	14.8	-3.9	1.4	-1.2
Number of full brothers	1.5	1.9	5.0	2.2	-0.7	-0.4
Worry too long after embarrassment	0.8	1.3	2.6	-1.0	-1.6	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.5	1.3	1.1	-0.2	0.1
Wheeze or whistling in the chest in last year	3.1	5.6	9.0	3.0	-2.6	-1.0
Number of children fathered	0.9	1.0	2.6	0.3	1.6	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.2	2.7	-1.6	1.3	-1.4
Age at first live birth	3.2	5.7	17.2	0.1	0.0	4.1
Pulse wave peak to peak time	1.7	2.0	4.5	-1.0	-0.6	2.1
Health satisfaction	0.1	0.1	0.1	0.1	0.3	0.4
Shortness of breath walking on level ground	0.7	0.9	2.5	0.1	-1.6	0.3
Qualifications: College or University degree	1.0	3.2	7.5	-2.7	-0.3	1.4
Eye problems/disorders: None of the above	1.1	1.3	2.8	1.1	-1.7	-0.2
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.2	1.5	1.0	1.1
Emphysema/chronic bronchitis	1.2	1.4	3.6	-0.7	-1.9	-0.3
Medication for pain relief, constipation, heartburn	1.0	1.7	4.8	-2.2	0.5	0.3
Neck or shoulder pain in last month	1.1	1.6	3.6	0.5	-0.9	-1.9
Medication: Blood pressure	0.4	0.6	1.5	1.2	0.3	0.5
Angina (self-reported)	1.2	1.5	2.0	1.4	-1.0	1.2
Migraine (self-reported)	0.2	0.3	0.5	-0.7	0.2	-0.6
Medication: Ibuprofen	2.8	3.4	6.9	-0.9	-1.6	-2.6
Medication: Allopurinol	0.7	1.0	1.5	0.8	0.9	-1.2
Medication: Omeprazole	0.4	0.4	1.2	-0.3	1.1	-0.2
Medication: Seretide 50 evohaler	2.0	2.3	6.5	2.5	0.4	0.4
Mean time to correctly identify matches	0.6	1.2	2.2	1.1	0.3	1.5
Heart disease (mother)	1.6	1.9	4.5	2.1	-0.9	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.3	0.1	-0.5	-0.5
Whole body fat mass	0.5	2.0	3.3	-1.6	1.8	0.3
Leg fat mass (right)	0.2	0.9	1.4	-0.5	1.2	-1.0
Arm predicted mass (right)	0.8	3.9	6.9	-1.7	1.4	2.6
Pulse rate, automated reading	0.1	0.2	0.4	-0.4	-0.2	0.6
Alcohol intake frequency.	0.2	0.4	0.5	0.6	0.4	0.7
Comparative height size at age 10	1.5	8.5	12.7	-2.2	2.8	3.6
Number of full sisters	0.8	0.9	2.1	1.4	0.9	-0.1
Suffer from ‘nerves’	0.7	1.2	2.6	1.6	0.1	-0.9
Overall health rating	3.3	7.1	14.8	3.8	-2.5	-0.3
Chest pain or discomfort	2.0	2.9	5.7	0.4	-2.4	-1.7
Had major operations	0.3	0.4	1.0	1.0	0.4	0.1
Age at last live birth	1.9	2.7	7.7	-0.4	0.5	2.8
Family relationship satisfaction	1.0	1.3	2.9	-0.3	0.9	-1.7
Leg pain on walking	0.1	0.2	0.3	0.1	-0.5	0.4
Qualifications: NVQ or HND or HNC or equivalent	2.9	3.5	7.6	-1.0	1.4	-2.7
Commuting to job workplace: Car/motor vehicle	1.7	2.0	3.6	-1.5	1.9	-0.0
Illness, injury, bereavement, stress in last 2 years	3.8	4.7	12.5	-1.2	0.2	3.5
Medication: Aspirin	0.3	0.3	0.6	0.6	0.7	0.3
Supplements: Vitamin C	0.3	0.4	1.0	-0.3	1.0	-0.3
Knee pain experienced in last month	0.7	1.0	2.4	-0.8	-0.2	-1.6
Hypertension (Self-reported)	0.3	0.9	1.6	-0.8	0.5	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.5	0.5	0.2	1.6
Illnesses of father: Heart disease	1.4	1.9	4.6	-1.0	2.1	0.3
Illnesses of siblings: Diabetes	1.6	1.9	4.5	1.0	-2.1	0.5
Smoking status: Previous	0.1	0.2	0.5	0.7	0.2	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.2	5.9	-2.4	-0.6	0.5
Whole body fat-free mass	1.8	10.1	16.4	-3.4	1.6	4.0
Leg fat-free mass (right)	2.0	10.9	16.0	-4.0	1.1	3.9
Arm fat percentage (left)	0.3	1.2	1.8	-1.3	0.8	-1.1
Average weekly red wine intake	3.1	4.6	7.1	-2.7	2.4	-0.9
Handedness (chirality/laterality): Left-handed	1.8	2.2	5.0	-2.2	-0.6	1.1
Mood swings	2.8	5.1	8.8	1.1	-2.3	-3.0
Loneliness, isolation	1.0	1.4	3.3	1.8	-0.1	-0.9
Long-standing illness, disability or infirmity	1.6	2.4	7.2	2.7	-0.1	-0.1
Ever had bowel cancer screening	0.8	0.9	2.0	0.5	0.7	1.4
Diabetes diagnosed by doctor	0.8	1.3	3.3	1.8	-0.2	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.6	3.4	-1.8	-1.1	-1.8
Friendships satisfaction	0.7	0.8	1.5	-0.6	-1.2	0.8
Qualifications: nursing, teaching	0.3	0.5	1.4	-1.2	0.0	0.2
Commuting to job workplace: Walk	2.5	2.7	3.2	1.7	-1.8	1.4
Eye problems/disorders: Cataract	0.5	0.6	1.5	-1.2	0.2	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	3.8	-1.9	0.3	0.7
Medication for cholesterol	0.9	1.4	2.7	0.9	-0.8	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.3	5.9	0.5	-0.9	2.4
Back pain experienced in last month	1.1	1.6	3.1	1.8	-0.9	-0.9
Mineral and other dietary supplements	5.6	7.5	19.2	1.5	-4.4	-1.0
Breast cancer (self-reported)	0.6	0.7	1.9	-0.5	-1.4	-0.2
Asthma (self-reported)	0.1	0.1	0.1	0.4	-0.3	-0.3
Osteoporosis (self-reported)	0.9	1.1	2.5	0.4	0.7	1.6
Osteoarthritis (self-reported)	0.2	0.3	0.6	0.1	-0.4	-0.8
Medication: Aspirin	0.4	0.5	0.6	0.8	0.7	0.6
Medication: Gliclazide	0.2	0.3	0.3	0.4	0.6	0.6
Illnesses of father: None of the above (group 1)	0.7	0.9	2.0	1.4	-0.4	-0.7
Smoking status: Current	0.0	0.1	0.1	0.3	-0.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	3.9	7.7	-2.8	0.1	-2.0
Whole body water mass	1.8	10.1	16.6	-3.4	1.5	4.1
Leg predicted mass (right)	2.1	11.2	16.3	-4.0	1.1	4.0
Arm fat mass (left)	0.3	1.3	2.2	-1.5	1.3	-0.0
Number of self-reported non-cancer illnesses	1.1	1.9	4.1	1.2	2.0	0.4
Average weekly champagne plus white wine intake	0.7	0.9	2.5	-0.0	-0.5	1.6
Miserableness	2.5	4.4	7.1	-1.1	-2.2	-2.7
Guilty feelings	1.7	2.5	5.3	0.8	-1.3	-2.3
Wears glasses or contact lenses	0.1	0.2	0.3	0.6	-0.3	0.2
Ever taken oral contraceptive pill	0.3	0.3	0.6	-0.2	-0.5	-0.8
Hearing aid user	1.4	1.6	1.9	-1.2	-1.2	-1.4
Mother’s age at death	0.9	1.1	1.4	-1.1	0.9	-1.2
Financial situation satisfaction	0.2	0.2	0.4	-0.6	0.5	-0.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.9	-0.1	-0.6	-1.4
Commuting to job workplace: Public transport	0.2	0.3	0.4	-0.1	0.6	-0.6
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	0.5	0.2	0.1
Medication: Blood pressure	0.1	0.3	0.8	-0.9	-0.2	-0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.9	1.0	0.5	-0.2
Supplements: Fish oil (including cod liver oil)	4.0	5.2	7.9	-2.3	2.8	1.5
High cholesterol (Self-reported)	0.4	0.6	1.7	1.3	0.5	-0.0
Medication: Bendroflumethiazide	1.7	2.5	4.7	-1.0	2.2	-1.3
Medication: Paracetamol	0.6	1.0	2.3	1.5	-0.8	0.3
Medication: Lisinopril	0.3	0.3	0.8	-0.1	-0.9	-0.5
Medication: Atorvastatin	0.8	1.0	2.8	0.3	-0.1	-1.7
Illnesses of father: High blood pressure	0.6	0.8	2.0	1.4	-0.2	0.6
Alcohol drinker status: Never	0.4	0.5	1.2	1.1	0.2	-0.5
Ever smoked	0.3	0.5	1.4	-0.1	1.2	0.1
Basal metabolic rate	1.5	8.4	11.2	-3.3	1.7	3.3
Leg fat percentage (left)	0.9	3.2	7.8	0.8	1.0	-2.8
Arm fat-free mass (left)	1.0	4.9	7.4	-1.9	1.9	2.7
Number of operations (self-reported)	0.1	0.1	0.3	-0.6	0.3	0.1
Average weekly beer plus cider intake	3.1	4.5	11.2	3.4	-1.1	-0.9
Irritability	2.9	4.9	8.1	0.9	-2.4	-2.9
Risk taking	0.4	0.6	1.6	-0.4	0.2	-1.3
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.6	-1.0	0.4	1.3
Fractured/broken bones in last 5 years	1.4	1.9	3.1	-1.6	0.3	-1.8
Age started oral contraceptive pill	2.0	2.5	3.7	1.2	1.5	1.9
Diastolic blood pressure, automated reading	1.0	3.1	9.1	-3.0	0.1	0.6
Ever depressed for a whole week	5.6	7.0	12.5	-2.0	2.1	-3.5
Unable to work because of sickness or disability	0.8	1.1	1.8	1.4	-0.1	1.2
Commuting to job workplace: Cycle	1.0	1.2	2.7	-1.6	0.4	-0.9
Myopia	0.4	0.6	0.9	0.6	0.7	1.0
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.4	0.4	-0.8	-1.2
Cholesterol lowering medication	0.9	1.3	2.0	0.8	1.4	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.1	0.6	1.0	-0.4
Pain experienced in last month	0.5	0.8	1.8	0.5	-0.7	1.3
Supplements: Calcium	2.0	2.2	6.1	-0.6	2.5	0.5
Basal cell carcinoma (self-reported)	0.3	0.4	1.0	-1.0	-0.2	-0.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.6	-0.2	0.7	0.7
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	0.9	-0.8	1.0	0.3
Heart disease (siblings)	0.9	1.1	3.3	0.3	0.0	-1.8
Alcohol drinker status: Previous	1.1	1.2	3.3	1.8	0.6	0.0
Pack years of smoking	0.2	0.2	0.4	0.7	0.5	0.1
Impedance of whole body	0.4	2.1	4.7	1.1	-0.7	-2.2
Leg fat mass (left)	0.2	0.9	1.3	-0.6	1.1	-1.0
Arm predicted mass (left)	1.0	5.1	6.5	-2.0	2.2	2.5