Hub : Genes

MCMBP

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.106 0.031 6.5e-06 0.007 0.053 0.052 0.053 0.025 0.044 4.6e-07 5.7e-07 4.8e-07 0.00046
2 GTEx Cells Transformed fibroblasts 0.137 0.053 3.4e-03 -0.002 NA -0.001 NA -0.001 0.450 NA 4.1e-01 NA 0.38000
3 GTEx Heart Atrial Appendage 0.217 0.073 1.3e-03 -0.003 NA 0.005 NA 0.000 0.460 NA 1.9e-01 NA 0.30000

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.2 0.3 0.5 0.6 0.7 -0.1
Bipolar Disorder or Schizophrenia 0.3 0.7 1.4 0.6 1.2 -0.6
Depressed Affect (Nagel 2018) 2.9 6.1 11.6 0.8 -2.4 -3.4
Depression (Nagel 2018) 0.6 0.9 2.4 0.3 -1.6 -0.5
Intelligence (Savage-Jansen 2018) 0.3 0.8 1.0 -0.9 -1.0 -0.9
Neuroticism (Nagel 2018) 3.5 8.2 12.7 2.0 -2.8 -3.6
Schizophrenia (2018) 0.2 0.3 0.5 0.4 0.7 -0.6
Schizophrenia vs Biploar Disorder 0.8 1.0 2.2 -0.9 -0.0 1.5
Worry (Nagel 2018) 1.2 2.6 3.5 1.9 -1.4 -1.5
Alzheimer’s Disease (in mother) 0.0 0.0 0.0 -0.2 -0.2 -0.1
Alzheimer’s Disease (in father) 1.2 1.3 3.5 -1.9 -0.3 0.5
Alzheimer’s Disease (including proxy) 0.3 0.4 0.8 -0.9 -0.5 0.4
Crohns Disease (2017) 0.5 1.2 3.3 1.8 -0.5 -0.1
Irritable Bowel Disease (IBD) 0.2 0.5 0.8 0.9 -0.1 0.9
Ulcerative Colitis (UC) 0.3 0.5 1.0 -0.7 0.3 1.0
Major Depression (MDD) 1.5 1.9 4.1 0.7 2.0 -1.0
Reaction Time 0.3 0.6 1.3 1.2 -0.3 0.7
Verbal and Numeric Reasoning (VNR) 0.6 1.5 2.5 -0.8 -1.1 -1.6
Breast Cancer 1.3 3.2 7.2 2.7 1.3 -0.8
Ovarian Cancer 0.6 0.8 2.1 -1.4 -0.3 0.4
Prostate Cancer 0.5 0.6 1.1 -1.1 0.9 0.1
Age at First Birth 1.7 2.5 3.0 1.6 -1.7 1.4
Bipolar Disorder (2011) 0.2 0.2 0.5 0.7 0.2 -0.2
Body Mass Index (BMI) (2010) 3.2 4.4 9.2 -3.0 1.9 0.4
Coronary Artery Disease (CAD) 0.6 0.8 1.8 0.5 -1.3 -0.6
Crohns Disease (2012) 0.5 0.9 1.3 1.2 -0.2 1.1
Mean Putamen Volume 2.4 2.8 3.6 -1.9 1.9 1.1
Fasting Glucose 1.5 1.8 3.6 -0.5 -1.3 -1.9
HbA1C 2.0 2.2 6.2 0.5 0.4 -2.5
HDL Cholesterol 0.2 0.3 0.5 0.7 -0.4 0.5
LDL Cholesterol 1.1 1.8 4.1 0.1 1.2 -2.0
Lupus 0.7 1.0 1.6 -1.3 0.9 0.7
Neuroticism (2016) 0.5 0.7 1.6 0.6 -1.3 -0.3
Primary Biliary Cirrhosis 0.2 0.3 0.4 0.6 -0.5 0.6
Rheumatoid Arthritis 2.4 3.4 5.0 -2.0 1.0 -2.2
Schizophrenia (2014) 0.2 0.5 1.0 0.4 0.6 -1.0
Triglycerides 0.7 1.2 2.2 -0.6 1.0 -1.5
Type 2 Diabetes (T2D) (2012) 0.6 0.6 1.1 -0.6 -0.7 -1.1
Ulcerative Colitis 0.8 1.2 2.3 -0.4 -1.0 1.5
Blood Eosinophil Count 0.1 0.7 1.7 -0.1 -1.3 -0.6
Blood Platelet Count 0.1 0.8 1.5 -0.8 -0.3 1.2
Blood Red Count 0.0 0.4 0.9 -0.3 -0.9 0.3
Blood White Count 0.3 2.5 5.2 2.3 -1.5 0.3
Heel T-Score 0.7 5.2 9.6 0.1 -2.4 -3.1
BMI 0.5 2.7 4.8 -1.4 2.2 1.1
Height 2.8 54.0 93.5 -8.0 2.1 9.7
Waist Hip Ratio (WHR) 0.4 1.7 4.8 2.2 0.5 -0.0
Systolic Blood Pressure 1.3 6.6 10.8 -3.3 -2.3 -1.9
Smoking Status 0.3 0.7 1.7 0.6 -0.1 -1.3
Allergy or Eczema 1.8 4.7 9.8 -3.1 -0.1 2.0
Cardiovascular Disease 0.0 0.1 0.2 -0.0 -0.5 -0.2
Hypothyroidism (self reported) 0.7 1.7 2.0 1.1 -1.4 1.4
Respiratory disease 0.9 2.1 3.9 1.5 -2.0 -0.3
Type 2 Diabetes (T2D) (2018) 0.4 0.7 1.2 1.1 -0.3 -0.9
Lung FEV1/FVC ratio 1.2 6.1 12.4 -3.5 1.9 -1.5
Lung FVC 0.8 3.9 9.0 -3.0 -0.6 -1.5
Neuroticism 1.5 3.6 6.2 1.3 -1.6 -2.5
Chronotype (morning person) 0.8 1.9 3.6 -0.9 -1.1 1.9
Hair Pigment 0.1 1.4 2.6 0.0 -1.3 -1.6
Tanning 0.2 1.9 2.2 1.1 -1.5 -1.5
Hand grip strength (left) 0.8 2.1 4.7 -2.2 -0.3 1.2
Number of treatments/medications taken 0.4 0.7 1.5 1.2 0.0 -0.9
Average weekly spirits intake 1.7 2.1 3.7 1.6 0.5 -1.9
Sensitivity / hurt feelings 0.8 1.4 2.7 1.1 -1.6 -0.6
Frequency of depressed mood in last 2 weeks 1.0 1.4 2.1 0.3 -1.5 -1.4
Hearing difficulty/problems: Yes 0.5 0.7 0.9 1.0 0.7 -0.8
Relative age of first facial hair 0.2 0.4 1.0 0.5 -1.0 0.1
Other serious medical condition/disability diagnosed by doctor 1.6 2.0 3.3 1.8 0.5 1.6
Ever used hormone-replacement therapy (HRT) 2.4 3.1 7.7 0.5 1.1 -2.8
Ever had hysterectomy (womb removed) 0.3 0.4 1.0 0.3 -1.0 -0.4
Systolic blood pressure, automated reading 0.1 0.3 0.9 -0.9 0.2 -0.1
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 1.8 -0.6 1.4 -0.7
Angina 0.9 1.1 2.0 1.4 -1.0 0.6
Medication for hormone replacement therapy 0.8 0.9 2.1 -0.2 0.7 -1.4
Vitamin and mineral supplements 4.1 5.6 14.3 1.5 -3.8 0.4
Supplements: Zinc 0.3 0.3 0.7 -0.1 0.5 0.8
Medication: Co-codamol 1.9 2.2 4.3 0.5 -1.5 -2.1
Medication: Metformin 1.1 1.5 4.5 2.1 -0.0 0.1
Diabetes (father) 1.1 1.4 3.8 -1.9 0.1 0.7
Diabetes (mother) 1.2 1.5 4.4 0.1 -2.1 -0.4
Severe depression (siblings) 2.0 2.2 3.9 0.7 1.5 -2.0
Pack years adult smoking proportion 0.3 0.5 0.8 0.8 0.9 -0.2
Impedance of leg (right) 1.6 7.7 14.7 2.9 -0.0 -3.8
Leg fat-free mass (left) 1.8 9.6 13.7 -3.7 1.3 3.7
Trunk fat percentage 0.4 1.7 3.6 -1.1 1.9 -0.5
Hand grip strength (right) 0.5 1.3 2.0 -1.3 -0.4 1.4
Townsend deprivation index at recruitment 0.7 1.0 2.2 -0.2 -0.9 -1.5
Current tobacco smoking 0.1 0.2 0.3 0.6 0.1 -0.4
Average weekly fortified wine intake 0.2 0.2 0.4 -0.4 0.6 0.3
Maternal smoking around birth 0.4 0.5 1.2 0.1 -0.7 -1.1
Fed-up feelings 3.0 5.4 7.9 1.0 -2.8 -2.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.1 -0.6 -0.4 -1.1
Relative age voice broke 0.5 0.7 1.3 -0.2 -1.2 0.9
Taking other prescription medications 0.9 1.4 3.9 2.0 0.1 -0.5
Age when periods started (menarche) 0.9 2.1 4.5 2.1 -0.9 -1.1
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 1.7 0.0 -1.3 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.2 -0.4 -0.5 -0.4
Tinnitus: Yes, but not now, but have in the past 2.0 2.1 4.5 -0.1 1.3 -2.1
Qualifications: CSEs or equivalent 0.0 0.0 0.0 0.2 0.2 0.1
Serious illness, injury or assault to yourself 0.5 0.6 1.0 0.7 0.6 -1.0
High blood pressure 0.2 0.6 0.6 -0.7 0.8 0.8
Hayfever, allergic rhinitis or eczema 1.4 3.0 6.1 -2.5 1.0 1.4
Multivitamins +/- minerals 3.0 3.8 9.4 -1.4 3.1 0.0
Stomach or abdominal pain in last month 0.5 0.7 2.0 0.2 0.0 -1.4
Supplements: Glucosamine 4.2 5.5 12.2 -1.9 3.5 0.7
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 0.9 0.9 0.6 -0.2
Medication: Atenolol 1.2 1.5 2.9 -0.4 1.7 1.2
Medication: Levothyroxine sodium 0.9 1.5 3.1 1.1 -0.5 1.8
Sitting height 1.1 8.0 13.9 -3.2 -0.2 3.7
Chronic bronchitis/emphysema (father) 0.7 0.8 2.0 -0.6 -0.1 -1.4
High blood pressure (mother) 0.4 0.5 0.8 0.6 -0.9 -0.6
Body mass index (BMI) 0.2 0.8 1.8 -0.7 1.4 -0.4
Impedance of leg (left) 1.7 8.2 17.0 2.7 -0.4 -4.1
Leg predicted mass (left) 1.9 9.9 14.6 -3.7 1.3 3.8
Trunk fat mass 0.5 2.2 3.3 -1.7 1.8 0.7
Waist circumference 0.5 1.7 3.2 -0.0 1.8 1.4
Number of incorrect matches in round 0.6 1.0 1.7 0.5 1.3 1.0
Past tobacco smoking 0.0 0.1 0.2 -0.5 -0.0 0.1
Alcohol usually taken with meals 3.3 5.4 14.1 -3.8 1.4 -0.4
Nervous feelings 0.6 1.1 1.6 1.2 0.6 1.3
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 1.8 0.2 -1.1 -1.3
Hearing difficulty/problems with background noise 0.4 0.6 1.4 -0.1 -0.6 -1.2
Hair/balding pattern: Pattern 2 1.1 1.4 3.8 0.5 -2.0 -0.3
Had menopause 0.8 1.0 1.1 1.0 0.8 1.1
Had other major operations 1.4 1.7 3.1 -1.4 -1.8 -0.3
Forced vital capacity (FVC) 1.1 4.3 11.2 -3.4 -1.2 0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.5 -0.7 -0.5 -0.2
Ever unenthusiastic/disinterested for a whole week 1.8 2.3 5.5 0.1 1.1 -2.4
Qualifications: None of the above 0.8 1.7 4.3 2.1 -0.4 -0.7
Financial difficulties in last 2 years 1.4 1.8 2.8 1.7 -0.3 -1.6
Mouth/teeth dental problems 0.7 1.1 1.7 0.9 0.9 -1.3
Heart attack 0.2 0.3 0.5 0.0 0.7 0.7
Allergy 0.5 1.1 1.6 1.2 -0.6 -1.3
Pain all over the body in last month 0.6 0.6 0.9 0.8 -1.0 -0.5
Diabetes (self-reported) 1.0 1.6 3.6 1.9 -0.8 -0.7
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 1.0 0.1 1.0 0.8
Medication: Ramipril 0.3 0.4 1.1 1.1 0.1 0.3
Medication: Simvastatin 1.1 1.6 4.3 2.1 0.4 0.7
Fluid intelligence score 0.3 0.5 1.6 0.1 0.2 -1.3
Illnesses of siblings 0.3 0.5 0.7 0.3 0.9 0.7
Neuroticism score 2.0 4.1 6.9 0.8 -2.2 -2.6
Weight 0.9 4.2 5.8 -2.4 2.0 1.7
Impedance of arm (right) 0.0 0.2 0.6 -0.8 -0.0 -0.1
Arm fat percentage (right) 0.4 1.4 1.9 -1.3 1.4 -0.9
Trunk fat-free mass 1.6 9.3 15.4 -3.2 1.6 3.9
Hip circumference 0.7 3.0 4.3 -2.1 1.6 1.5
Time employed in main current job 4.5 5.2 8.4 2.9 -1.7 2.0
Alcohol intake versus 10 years previously 0.1 0.2 0.4 0.3 0.6 0.1
Father’s age at death 0.5 0.7 2.0 -0.1 0.2 -1.4
Worrier / anxious feelings 0.6 1.1 2.0 -0.5 -1.4 -1.0
Frequency of tiredness / lethargy in last 2 weeks 1.9 3.2 6.5 2.5 -1.0 -1.4
Falls in the last year 0.9 1.2 3.3 0.5 0.2 -1.8
Hair/balding pattern: Pattern 3 0.8 1.2 3.2 -0.5 0.3 -1.8
Number of live births 1.9 2.8 3.9 -1.6 -1.3 2.0
Forced expiratory volume in 1-second (FEV1) 1.8 6.2 18.5 -4.3 -0.2 -0.2
Pulse rate 0.8 1.4 1.8 -1.2 0.8 1.4
Happiness 0.4 0.4 0.9 -0.4 0.5 -0.9
Noisy workplace 0.1 0.2 0.4 -0.0 0.7 -0.2
Qualifications: A levels/AS levels or equivalent 1.5 3.4 4.4 -1.8 -1.6 -2.1
Serious illness, injury or assault of a close relative in last 2 years 1.8 2.1 3.8 0.3 -1.5 -1.9
Mouth/teeth dental problems: Dentures 0.3 0.5 1.1 -1.1 -0.4 0.5
Asthma 0.0 0.1 0.2 0.4 -0.3 -0.1
Medication: Ibuprofen (e.g. Nurofen) 1.8 2.3 3.6 0.2 -1.8 -1.9
Medication: Cholesterol lowering 1.0 1.6 3.1 1.8 -1.2 0.3
Depression (self-reported) 0.6 0.8 1.9 0.6 1.4 0.1
Medication: Lansoprazole 0.5 0.6 1.5 1.2 0.4 -0.2
Prospective memory result 1.2 1.5 4.1 -0.6 -0.1 -2.0
Lung cancer (father) 2.1 2.4 5.0 1.1 -2.2 -1.0
Illnesses of mother 1.0 1.2 3.1 -0.4 0.6 1.8
Forced expiratory volume in 1-second (FEV1), Best measure 2.2 7.1 20.3 -4.5 -0.4 -0.9
Pulse wave Arterial Stiffness index 1.1 1.3 2.5 0.8 0.9 -1.6
Impedance of arm (left) 0.1 0.5 0.7 -0.8 -0.9 -0.4
Arm fat mass (right) 0.4 1.8 2.9 -1.6 1.7 0.0
Trunk predicted mass 1.6 9.0 14.7 -3.1 1.7 3.8
Standing height 1.4 14.3 24.4 -4.0 1.6 4.9
Length of working week for main job 0.2 0.3 0.4 0.7 -0.4 -0.4
Exposure to tobacco smoke at home 0.8 0.8 1.2 1.1 -0.4 -1.1
Breastfed as a baby 0.7 0.8 1.8 1.3 -0.7 0.4
Tense / ‘highly strung’ 0.7 1.2 2.2 1.2 -1.5 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.4 2.2 3.1 1.7 0.8 -1.8
Hair/balding pattern: Pattern 4 1.1 2.8 4.3 0.7 2.1 1.9
Birth weight of first child 0.2 0.3 0.6 -0.2 -0.5 0.8
Peak expiratory flow (PEF) 1.4 3.4 9.9 -3.1 0.1 -0.5
Pulse wave reflection index 2.4 3.0 5.6 1.0 -1.5 -2.4
Ever highly irritable/argumentative for 2 days 0.7 0.8 1.7 0.6 -0.7 -1.3
Loud music exposure frequency 1.4 1.6 4.6 -0.0 0.2 -2.1
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.3 0.3 -0.5 -0.6
Mouth/teeth dental problems: Bleeding gums 0.7 1.0 2.4 0.5 -0.5 1.5
Blood clot in the leg (DVT) 0.5 0.6 1.0 -0.8 1.0 0.3
Medication: Paracetamol 1.1 1.8 5.2 2.3 -0.2 0.2
Headache pain in last month 0.9 1.5 2.5 -1.1 -0.9 -1.6
Medication for cholesterol, blood pressure or diabetes 0.9 1.4 4.0 -2.0 0.4 -0.4
Glaucoma (self-reported) 0.1 0.2 0.3 0.5 0.1 0.4
Gout (self-reported) 0.9 1.2 3.5 1.9 0.4 0.0
Hypothyroidism/myxoedema (self-reported) 0.8 1.7 2.8 1.7 -0.9 1.2
Medication: Amlodipine 0.0 0.1 0.1 0.3 0.1 0.3
Medication: Ventolin 100micrograms inhaler 1.1 1.5 2.0 1.4 -1.0 1.2
Birth weight 0.2 0.4 0.5 -0.7 0.7 -0.2
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.1 -1.1 -1.1 0.4
High blood pressure (siblings) 0.2 0.3 0.7 -0.4 -0.3 0.8
Forced vital capacity (FVC), Best measure 1.2 4.4 12.0 -3.5 -1.1 0.3
Body fat percentage 0.4 1.7 3.0 -0.8 1.7 -1.2
Leg fat percentage (right) 0.8 3.0 6.5 1.0 1.3 -2.6
Arm fat-free mass (right) 0.8 4.1 6.9 -2.0 1.2 2.6
Exposure to tobacco smoke outside home 1.1 1.5 2.4 -1.3 -0.6 -1.5
Comparative body size at age 10 2.2 6.1 14.8 -3.9 1.4 -1.2
Number of full brothers 1.5 1.9 5.0 2.2 -0.7 -0.4
Worry too long after embarrassment 0.8 1.3 2.6 -1.0 -1.6 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.5 1.3 1.1 -0.2 0.1
Wheeze or whistling in the chest in last year 3.1 5.6 9.0 3.0 -2.6 -1.0
Number of children fathered 0.9 1.0 2.6 0.3 1.6 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 1.8 2.2 2.7 -1.6 1.3 -1.4
Age at first live birth 3.2 5.7 17.2 0.1 0.0 4.1
Pulse wave peak to peak time 1.7 2.0 4.5 -1.0 -0.6 2.1
Health satisfaction 0.1 0.1 0.1 0.1 0.3 0.4
Shortness of breath walking on level ground 0.7 0.9 2.5 0.1 -1.6 0.3
Qualifications: College or University degree 1.0 3.2 7.5 -2.7 -0.3 1.4
Eye problems/disorders: None of the above 1.1 1.3 2.8 1.1 -1.7 -0.2
Mouth/teeth dental problems: Loose teeth 1.2 1.4 2.2 1.5 1.0 1.1
Emphysema/chronic bronchitis 1.2 1.4 3.6 -0.7 -1.9 -0.3
Medication for pain relief, constipation, heartburn 1.0 1.7 4.8 -2.2 0.5 0.3
Neck or shoulder pain in last month 1.1 1.6 3.6 0.5 -0.9 -1.9
Medication: Blood pressure 0.4 0.6 1.5 1.2 0.3 0.5
Angina (self-reported) 1.2 1.5 2.0 1.4 -1.0 1.2
Migraine (self-reported) 0.2 0.3 0.5 -0.7 0.2 -0.6
Medication: Ibuprofen 2.8 3.4 6.9 -0.9 -1.6 -2.6
Medication: Allopurinol 0.7 1.0 1.5 0.8 0.9 -1.2
Medication: Omeprazole 0.4 0.4 1.2 -0.3 1.1 -0.2
Medication: Seretide 50 evohaler 2.0 2.3 6.5 2.5 0.4 0.4
Mean time to correctly identify matches 0.6 1.2 2.2 1.1 0.3 1.5
Heart disease (mother) 1.6 1.9 4.5 2.1 -0.9 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.3 0.1 -0.5 -0.5
Whole body fat mass 0.5 2.0 3.3 -1.6 1.8 0.3
Leg fat mass (right) 0.2 0.9 1.4 -0.5 1.2 -1.0
Arm predicted mass (right) 0.8 3.9 6.9 -1.7 1.4 2.6
Pulse rate, automated reading 0.1 0.2 0.4 -0.4 -0.2 0.6
Alcohol intake frequency. 0.2 0.4 0.5 0.6 0.4 0.7
Comparative height size at age 10 1.5 8.5 12.7 -2.2 2.8 3.6
Number of full sisters 0.8 0.9 2.1 1.4 0.9 -0.1
Suffer from ‘nerves’ 0.7 1.2 2.6 1.6 0.1 -0.9
Overall health rating 3.3 7.1 14.8 3.8 -2.5 -0.3
Chest pain or discomfort 2.0 2.9 5.7 0.4 -2.4 -1.7
Had major operations 0.3 0.4 1.0 1.0 0.4 0.1
Age at last live birth 1.9 2.7 7.7 -0.4 0.5 2.8
Family relationship satisfaction 1.0 1.3 2.9 -0.3 0.9 -1.7
Leg pain on walking 0.1 0.2 0.3 0.1 -0.5 0.4
Qualifications: NVQ or HND or HNC or equivalent 2.9 3.5 7.6 -1.0 1.4 -2.7
Commuting to job workplace: Car/motor vehicle 1.7 2.0 3.6 -1.5 1.9 -0.0
Illness, injury, bereavement, stress in last 2 years 3.8 4.7 12.5 -1.2 0.2 3.5
Medication: Aspirin 0.3 0.3 0.6 0.6 0.7 0.3
Supplements: Vitamin C 0.3 0.4 1.0 -0.3 1.0 -0.3
Knee pain experienced in last month 0.7 1.0 2.4 -0.8 -0.2 -1.6
Hypertension (Self-reported) 0.3 0.9 1.6 -0.8 0.5 1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.5 0.5 0.2 1.6
Illnesses of father: Heart disease 1.4 1.9 4.6 -1.0 2.1 0.3
Illnesses of siblings: Diabetes 1.6 1.9 4.5 1.0 -2.1 0.5
Smoking status: Previous 0.1 0.2 0.5 0.7 0.2 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.2 5.9 -2.4 -0.6 0.5
Whole body fat-free mass 1.8 10.1 16.4 -3.4 1.6 4.0
Leg fat-free mass (right) 2.0 10.9 16.0 -4.0 1.1 3.9
Arm fat percentage (left) 0.3 1.2 1.8 -1.3 0.8 -1.1
Average weekly red wine intake 3.1 4.6 7.1 -2.7 2.4 -0.9
Handedness (chirality/laterality): Left-handed 1.8 2.2 5.0 -2.2 -0.6 1.1
Mood swings 2.8 5.1 8.8 1.1 -2.3 -3.0
Loneliness, isolation 1.0 1.4 3.3 1.8 -0.1 -0.9
Long-standing illness, disability or infirmity 1.6 2.4 7.2 2.7 -0.1 -0.1
Ever had bowel cancer screening 0.8 0.9 2.0 0.5 0.7 1.4
Diabetes diagnosed by doctor 0.8 1.3 3.3 1.8 -0.2 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 2.4 2.6 3.4 -1.8 -1.1 -1.8
Friendships satisfaction 0.7 0.8 1.5 -0.6 -1.2 0.8
Qualifications: nursing, teaching 0.3 0.5 1.4 -1.2 0.0 0.2
Commuting to job workplace: Walk 2.5 2.7 3.2 1.7 -1.8 1.4
Eye problems/disorders: Cataract 0.5 0.6 1.5 -1.2 0.2 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.9 1.5 3.8 -1.9 0.3 0.7
Medication for cholesterol 0.9 1.4 2.7 0.9 -0.8 1.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.0 2.3 5.9 0.5 -0.9 2.4
Back pain experienced in last month 1.1 1.6 3.1 1.8 -0.9 -0.9
Mineral and other dietary supplements 5.6 7.5 19.2 1.5 -4.4 -1.0
Breast cancer (self-reported) 0.6 0.7 1.9 -0.5 -1.4 -0.2
Asthma (self-reported) 0.1 0.1 0.1 0.4 -0.3 -0.3
Osteoporosis (self-reported) 0.9 1.1 2.5 0.4 0.7 1.6
Osteoarthritis (self-reported) 0.2 0.3 0.6 0.1 -0.4 -0.8
Medication: Aspirin 0.4 0.5 0.6 0.8 0.7 0.6
Medication: Gliclazide 0.2 0.3 0.3 0.4 0.6 0.6
Illnesses of father: None of the above (group 1) 0.7 0.9 2.0 1.4 -0.4 -0.7
Smoking status: Current 0.0 0.1 0.1 0.3 -0.1 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.9 3.9 7.7 -2.8 0.1 -2.0
Whole body water mass 1.8 10.1 16.6 -3.4 1.5 4.1
Leg predicted mass (right) 2.1 11.2 16.3 -4.0 1.1 4.0
Arm fat mass (left) 0.3 1.3 2.2 -1.5 1.3 -0.0
Number of self-reported non-cancer illnesses 1.1 1.9 4.1 1.2 2.0 0.4
Average weekly champagne plus white wine intake 0.7 0.9 2.5 -0.0 -0.5 1.6
Miserableness 2.5 4.4 7.1 -1.1 -2.2 -2.7
Guilty feelings 1.7 2.5 5.3 0.8 -1.3 -2.3
Wears glasses or contact lenses 0.1 0.2 0.3 0.6 -0.3 0.2
Ever taken oral contraceptive pill 0.3 0.3 0.6 -0.2 -0.5 -0.8
Hearing aid user 1.4 1.6 1.9 -1.2 -1.2 -1.4
Mother’s age at death 0.9 1.1 1.4 -1.1 0.9 -1.2
Financial situation satisfaction 0.2 0.2 0.4 -0.6 0.5 -0.1
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.9 -0.1 -0.6 -1.4
Commuting to job workplace: Public transport 0.2 0.3 0.4 -0.1 0.6 -0.6
Eye problems/disorders: Glaucoma 0.1 0.1 0.3 0.5 0.2 0.1
Medication: Blood pressure 0.1 0.3 0.8 -0.9 -0.2 -0.1
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.9 1.0 0.5 -0.2
Supplements: Fish oil (including cod liver oil) 4.0 5.2 7.9 -2.3 2.8 1.5
High cholesterol (Self-reported) 0.4 0.6 1.7 1.3 0.5 -0.0
Medication: Bendroflumethiazide 1.7 2.5 4.7 -1.0 2.2 -1.3
Medication: Paracetamol 0.6 1.0 2.3 1.5 -0.8 0.3
Medication: Lisinopril 0.3 0.3 0.8 -0.1 -0.9 -0.5
Medication: Atorvastatin 0.8 1.0 2.8 0.3 -0.1 -1.7
Illnesses of father: High blood pressure 0.6 0.8 2.0 1.4 -0.2 0.6
Alcohol drinker status: Never 0.4 0.5 1.2 1.1 0.2 -0.5
Ever smoked 0.3 0.5 1.4 -0.1 1.2 0.1
Basal metabolic rate 1.5 8.4 11.2 -3.3 1.7 3.3
Leg fat percentage (left) 0.9 3.2 7.8 0.8 1.0 -2.8
Arm fat-free mass (left) 1.0 4.9 7.4 -1.9 1.9 2.7
Number of operations (self-reported) 0.1 0.1 0.3 -0.6 0.3 0.1
Average weekly beer plus cider intake 3.1 4.5 11.2 3.4 -1.1 -0.9
Irritability 2.9 4.9 8.1 0.9 -2.4 -2.9
Risk taking 0.4 0.6 1.6 -0.4 0.2 -1.3
Ever had prostate specific antigen (PSA) test 0.8 0.9 1.6 -1.0 0.4 1.3
Fractured/broken bones in last 5 years 1.4 1.9 3.1 -1.6 0.3 -1.8
Age started oral contraceptive pill 2.0 2.5 3.7 1.2 1.5 1.9
Diastolic blood pressure, automated reading 1.0 3.1 9.1 -3.0 0.1 0.6
Ever depressed for a whole week 5.6 7.0 12.5 -2.0 2.1 -3.5
Unable to work because of sickness or disability 0.8 1.1 1.8 1.4 -0.1 1.2
Commuting to job workplace: Cycle 1.0 1.2 2.7 -1.6 0.4 -0.9
Myopia 0.4 0.6 0.9 0.6 0.7 1.0
Vascular/heart problems diagnosed by doctor 0.3 0.7 1.4 0.4 -0.8 -1.2
Cholesterol lowering medication 0.9 1.3 2.0 0.8 1.4 -1.2
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.1 0.6 1.0 -0.4
Pain experienced in last month 0.5 0.8 1.8 0.5 -0.7 1.3
Supplements: Calcium 2.0 2.2 6.1 -0.6 2.5 0.5
Basal cell carcinoma (self-reported) 0.3 0.4 1.0 -1.0 -0.2 -0.2
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.6 -0.2 0.7 0.7
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 0.9 -0.8 1.0 0.3
Heart disease (siblings) 0.9 1.1 3.3 0.3 0.0 -1.8
Alcohol drinker status: Previous 1.1 1.2 3.3 1.8 0.6 0.0
Pack years of smoking 0.2 0.2 0.4 0.7 0.5 0.1
Impedance of whole body 0.4 2.1 4.7 1.1 -0.7 -2.2
Leg fat mass (left) 0.2 0.9 1.3 -0.6 1.1 -1.0
Arm predicted mass (left) 1.0 5.1 6.5 -2.0 2.2 2.5