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chr11:7,949,791-11,027,552

Best TWAS P=2.16e-18 · Best GWAS P=1.88e-18 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TRIM66	0.09	0.05	bslmm	523	0.05	3.7e-07	5.4	6.5	1.1e-10	0.02	0.99	0.01	TRUE
2	GTEx	Adipose Subcutaneous	TRIM66	0.52	0.35	enet	42	0.40	3.5e-35	5.4	6.3	2.8e-10	0.04	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	AKIP1	0.08	0.08	lasso	5	0.09	8.1e-08	4.1	5.5	4.9e-08	-0.03	0.04	0.96	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-152H18.3	0.11	0.04	lasso	3	0.05	1.3e-03	5.2	-5.7	1.3e-08	-0.05	0.36	0.04	FALSE
5	GTEx	Adrenal Gland	TRIM66	0.23	0.20	lasso	8	0.18	3.3e-07	6.0	6.1	1.3e-09	0.01	0.51	0.14	FALSE
6	GTEx	Artery Aorta	TRIM66	0.33	0.29	lasso	10	0.30	6.5e-17	5.4	5.1	3.0e-07	0.01	0.99	0.01	FALSE
7	GTEx	Artery Coronary	TRIM66	0.54	0.34	enet	46	0.43	4.2e-16	5.4	8.8	2.2e-18	0.06	0.99	0.01	TRUE
8	GTEx	Artery Tibial	TRIM66	0.37	0.22	lasso	7	0.22	2.0e-17	5.2	5.6	2.6e-08	0.05	1.00	0.00	FALSE
9	GTEx	Artery Tibial	RP11-152H18.3	0.11	0.08	lasso	5	0.05	4.1e-05	6.0	-5.6	1.9e-08	0.00	0.70	0.10	FALSE
10	GTEx	Brain Cerebellar Hemisphere	SCUBE2	0.37	0.19	enet	32	0.18	1.9e-05	1.8	-5.3	9.9e-08	0.05	0.09	0.14	TRUE
11	GTEx	Brain Cortex	RP11-152H18.3	0.41	0.04	enet	25	0.11	7.6e-04	5.4	-7.2	6.9e-13	-0.07	0.09	0.34	FALSE
12	GTEx	Breast Mammary Tissue	RP11-152H18.3	0.16	0.02	enet	10	0.05	1.5e-03	5.2	-5.3	1.1e-07	0.00	0.24	0.05	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	TRIM66	0.50	0.49	lasso	6	0.48	1.0e-17	5.2	5.3	1.0e-07	0.02	1.00	0.00	FALSE
14	GTEx	Cells Transformed fibroblasts	TRIM66	0.48	0.32	enet	35	0.34	1.7e-26	5.2	5.8	5.9e-09	0.02	1.00	0.00	FALSE
15	GTEx	Colon Sigmoid	RP11-152H18.3	0.26	0.06	enet	16	0.11	9.3e-05	5.2	-5.7	1.1e-08	-0.04	0.30	0.05	FALSE
16	GTEx	Colon Transverse	TRIM66	0.28	0.28	lasso	5	0.30	1.3e-14	5.2	5.9	4.4e-09	0.04	1.00	0.00	TRUE
17	GTEx	Esophagus Gastroesophageal Junction	TRIM66	0.27	0.15	enet	16	0.30	1.7e-11	-5.8	6.1	1.3e-09	0.03	0.94	0.05	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	RP11-152H18.3	0.19	0.09	enet	9	0.12	2.8e-05	5.2	-6.0	1.7e-09	0.00	0.68	0.05	FALSE
19	GTEx	Esophagus Mucosa	TRIM66	0.40	0.44	lasso	9	0.47	5.7e-35	5.4	5.4	6.2e-08	0.02	1.00	0.00	FALSE
20	GTEx	Esophagus Muscularis	TRIM66	0.40	0.24	lasso	7	0.27	2.1e-16	5.2	6.0	2.6e-09	0.05	1.00	0.00	FALSE
21	GTEx	Esophagus Muscularis	RP11-152H18.3	0.12	0.05	lasso	6	0.10	8.2e-07	6.0	-5.9	3.6e-09	-0.06	0.60	0.06	TRUE
22	GTEx	Heart Atrial Appendage	TRIM66	0.39	0.31	lasso	9	0.35	2.8e-16	5.4	5.5	4.3e-08	0.02	0.98	0.02	FALSE
23	GTEx	Heart Atrial Appendage	RP11-152H18.3	0.27	0.11	lasso	5	0.11	8.9e-06	-5.8	-6.2	4.9e-10	-0.06	0.49	0.09	FALSE
24	GTEx	Heart Left Ventricle	TRIM66	0.44	0.35	lasso	7	0.35	3.2e-19	5.4	6.0	2.1e-09	0.01	0.98	0.02	FALSE
25	GTEx	Lung	TRIM66	0.53	0.38	enet	20	0.44	1.2e-36	5.4	5.7	1.1e-08	0.01	0.99	0.01	FALSE
26	GTEx	Muscle Skeletal	TRIM66	0.38	0.20	lasso	12	0.22	2.7e-21	5.2	5.7	1.5e-08	0.05	1.00	0.00	FALSE
27	GTEx	Ovary	TRIM66	0.29	0.19	lasso	7	0.22	5.4e-06	5.4	6.0	1.5e-09	0.01	0.18	0.18	FALSE
28	GTEx	Pancreas	TRIM66	0.33	0.27	lasso	2	0.25	6.8e-11	5.2	5.5	3.0e-08	0.03	0.99	0.00	FALSE
29	GTEx	Pancreas	AKIP1	0.10	-0.01	enet	14	0.00	4.5e-01	-3.3	6.4	1.2e-10	0.01	0.05	0.51	FALSE
30	GTEx	Pituitary	AKIP1	0.17	0.07	lasso	5	0.02	8.6e-02	6.3	6.2	4.5e-10	-0.02	0.03	0.68	FALSE
31	GTEx	Prostate	SBF2	0.21	0.05	lasso	7	0.03	6.7e-02	8.3	7.5	7.9e-14	0.94	0.05	0.70	FALSE
32	GTEx	Prostate	TRIM66	0.35	0.24	lasso	5	0.30	4.0e-08	6.0	5.6	2.0e-08	0.00	0.47	0.06	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	TRIM66	0.21	0.26	enet	11	0.26	8.9e-15	5.4	5.6	1.8e-08	0.02	0.99	0.01	FALSE
34	GTEx	Skin Sun Exposed Lower leg	TRIM66	0.44	0.39	lasso	8	0.39	1.9e-34	5.4	5.2	2.2e-07	0.01	1.00	0.00	FALSE
35	GTEx	Skin Sun Exposed Lower leg	AKIP1	0.05	0.05	enet	8	0.04	1.7e-04	6.2	5.9	2.8e-09	0.01	0.02	0.97	TRUE
36	GTEx	Small Intestine Terminal Ileum	TRIM66	0.19	0.15	lasso	3	0.21	1.8e-05	5.2	5.1	3.0e-07	0.03	0.22	0.07	FALSE
37	GTEx	Stomach	TRIM66	0.22	0.20	lasso	5	0.20	8.0e-10	5.2	5.4	5.7e-08	0.01	0.98	0.02	FALSE
38	GTEx	Testis	SBF2	0.10	0.01	lasso	5	0.02	5.0e-02	8.2	-8.1	4.5e-16	-0.98	0.04	0.89	TRUE
39	GTEx	Testis	TRIM66	0.33	0.41	lasso	3	0.41	9.1e-20	5.4	5.6	2.4e-08	0.01	0.99	0.01	FALSE
40	GTEx	Thyroid	TRIM66	0.49	0.36	enet	23	0.42	1.1e-34	5.4	5.5	3.0e-08	0.03	1.00	0.00	FALSE
41	GTEx	Whole Blood	TRIM66	0.19	0.16	lasso	8	0.15	1.1e-13	5.4	5.8	5.0e-09	0.01	0.99	0.01	FALSE
42	GTEx	Whole Blood	ST5	0.07	0.08	enet	18	0.05	3.3e-05	5.5	6.9	4.8e-12	-0.04	0.95	0.03	FALSE
43	GTEx	Whole Blood	RP11-152H18.3	0.04	0.02	lasso	4	0.01	2.0e-02	5.5	5.7	1.5e-08	-0.05	0.68	0.03	FALSE
44	METSIM	Adipose	TRIM66	0.37	0.30	bslmm	520	0.31	8.6e-48	5.4	5.3	1.2e-07	0.01	1.00	0.00	TRUE
45	NTR	Blood	ADM	0.04	0.04	enet	13	0.04	1.6e-13	8.3	-7.4	1.7e-13	-0.93	0.02	0.98	FALSE
46	NTR	Blood	TRIM66	0.07	0.09	enet	3	0.10	2.9e-29	5.2	5.5	2.8e-08	0.01	1.00	0.00	FALSE
47	ROSMAP	Brain Pre-frontal Cortex	TRIM66	0.06	0.11	lasso	3	0.10	7.0e-13	5.4	5.6	2.3e-08	0.02	1.00	0.00	FALSE
48	ROSMAP	Brain Pre-frontal Cortex	AKIP1	0.03	0.02	blup	359	0.01	9.0e-03	5.4	6.3	2.6e-10	0.04	0.07	0.85	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	SBF2-AS1	0.03	0.00	bslmm	362	0.01	4.4e-03	-2.5	7.3	2.9e-13	0.61	0.04	0.62	FALSE
50	YFS	Blood	ADM	0.08	0.11	enet	25	0.12	9.4e-36	8.2	-7.3	2.9e-13	-0.92	0.02	0.98	FALSE
51	YFS	Blood	TRIM66	0.53	0.50	bslmm	502	0.51	3.2e-199	5.2	5.7	9.5e-09	0.04	1.00	0.00	FALSE
52	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRIM66	0.24	0.18	enet	9	0.21	1.5e-17	5.4	5.2	2.0e-07	-0.03	0.01	0.99	TRUE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRIM66	0.14	0.14	lasso	5	0.15	5.8e-29	5.4	5.2	2.1e-07	0.01	0.05	0.95	FALSE
54	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TRIM66	0.47	0.30	lasso	4	0.29	9.2e-15	5.4	5.3	1.0e-07	0.02	0.05	0.95	FALSE
55	The Cancer Genome Atlas	Colon Adenocarcinoma	TRIM66	0.17	0.15	lasso	1	0.12	2.0e-07	5.4	5.4	6.1e-08	0.01	0.03	0.97	FALSE
56	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TRIM66	0.41	0.31	lasso	6	0.32	3.9e-36	5.4	5.3	9.0e-08	0.02	0.03	0.96	FALSE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRIM66	0.29	0.17	lasso	3	0.16	3.0e-18	5.2	5.4	7.0e-08	0.01	0.04	0.96	FALSE
58	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TRIM66	0.27	0.16	lasso	3	0.14	4.0e-07	5.4	5.3	8.6e-08	0.01	0.04	0.96	FALSE
59	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TRIM66	0.28	0.22	lasso	5	0.22	1.1e-14	5.4	5.8	8.7e-09	0.01	0.03	0.97	FALSE
60	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ADM	0.08	0.02	blup	36	0.03	1.8e-02	-3.9	5.4	5.8e-08	0.78	0.01	0.62	FALSE
61	The Cancer Genome Atlas	Rectum Adenocarcinoma	TRIM66	0.50	0.21	lasso	5	0.18	5.6e-05	5.4	5.6	2.1e-08	0.00	0.02	0.84	FALSE
62	The Cancer Genome Atlas	Soft Tissue Sarcoma	TRIM66	0.28	0.21	lasso	5	0.23	5.4e-14	5.4	5.9	2.8e-09	-0.01	0.00	1.00	FALSE
63	The Cancer Genome Atlas	Thyroid Carcinoma	TRIM66	0.48	0.49	lasso	9	0.50	4.3e-55	5.2	5.4	6.1e-08	0.02	0.06	0.94	FALSE