TWAS hub - AKIP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0820	0.0290	3.5e-06	0.076	NA	0.077	NA	0.090	8.8e-07	NA	6.7e-07	NA	8.1e-08
2	GTEx	Artery Tibial	0.1152	0.0453	2.6e-05	0.075	NA	0.093	NA	0.077	1.7e-06	NA	1.0e-07	NA	1.3e-06
3	GTEx	Brain Cerebellum	0.1480	0.0690	5.3e-03	0.032	NA	0.003	NA	0.026	4.1e-02	NA	2.5e-01	NA	5.9e-02
4	GTEx	Breast Mammary Tissue	0.1350	0.0600	1.7e-03	0.029	NA	0.047	NA	0.019	1.2e-02	NA	1.8e-03	NA	3.7e-02
5	GTEx	Breast Mammary Tissue (Male)	0.1852	0.1108	5.9e-02	-0.013	NA	-0.011	NA	-0.011	8.8e-01	NA	7.2e-01	NA	7.0e-01
6	GTEx	Cells EBV-transformed lymphocytes	0.1660	0.0610	3.1e-04	0.200	NA	0.157	NA	0.182	4.1e-07	NA	8.5e-06	NA	1.5e-06
7	GTEx	Cells Transformed fibroblasts	0.1160	0.0400	3.6e-07	0.089	NA	0.102	NA	0.099	3.3e-07	NA	4.4e-08	NA	7.1e-08
8	GTEx	Colon Transverse	0.1480	0.0620	1.1e-03	-0.005	NA	0.006	NA	-0.003	6.6e-01	NA	1.6e-01	NA	4.7e-01
9	GTEx	Esophagus Muscularis	0.2130	0.0750	1.9e-04	0.013	NA	0.075	NA	0.029	4.9e-02	NA	2.6e-05	NA	7.0e-03
10	GTEx	Lung	0.1144	0.0409	1.2e-05	0.060	NA	0.072	NA	0.090	2.1e-05	NA	3.3e-06	NA	2.0e-07
11	GTEx	Nerve Tibial	0.1567	0.0602	3.1e-06	0.068	NA	0.066	NA	0.080	1.5e-05	NA	1.9e-05	NA	2.7e-06
12	GTEx	Ovary	0.2460	0.1020	7.1e-03	0.022	NA	0.063	NA	0.042	9.2e-02	NA	1.2e-02	NA	3.5e-02
13	GTEx	Pancreas	0.0980	0.0480	6.5e-03	-0.007	NA	-0.003	NA	-0.007	9.0e-01	NA	4.5e-01	NA	1.0e+00
14	GTEx	Pituitary	0.1660	0.0820	9.9e-03	0.066	NA	0.017	NA	0.023	9.8e-03	NA	1.2e-01	NA	8.6e-02
15	GTEx	Skin Sun Exposed Lower leg	0.0500	0.0260	4.6e-03	0.047	NA	0.043	NA	0.035	8.4e-05	NA	1.7e-04	NA	6.1e-04
16	GTEx	Small Intestine Terminal Ileum	0.2320	0.0930	7.4e-04	0.201	NA	0.118	NA	0.011	2.9e-05	NA	1.4e-03	NA	1.8e-01
17	GTEx	Testis	0.1860	0.0600	3.2e-05	0.048	NA	0.108	NA	0.071	3.5e-03	NA	1.7e-05	NA	4.7e-04
18	GTEx	Thyroid	0.1560	0.0420	5.0e-13	0.227	NA	0.208	NA	0.214	2.7e-17	NA	6.8e-16	NA	2.6e-16
19	ROSMAP	Brain Pre-frontal Cortex	0.0342	0.0180	2.5e-03	0.024	0.012	-0.001	0.011	0.007	4.1e-04	0.009	4.9e-01	0.013	3.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Blood Platelet Count	14.7	170.1	256.0	-16.0	-11.5	-12.6	-11.4	-13.4	10.3	-12.6	-12.7	-11.4	-14.6	-14.6	-13.0	-12.4	-15.5	-14.4	-13.9	6.5	-13.8	-14.0
Blood Red Count	8.5	81.7	130.0	-10.4	-6.9	-9.3	-10.7	-9.9	6.9	-8.9	-7.9	-7.9	-11.4	-9.8	-9.2	-7.9	-10.3	-9.6	-10.5	3.5	-10.2	-7.1
Heel T-Score	5.7	45.0	106.1	7.4	7.5	6.5	4.3	6.8	3.0	10.3	4.9	8.7	7.7	6.9	4.5	2.0	7.9	9.7	6.2	5.1	7.0	4.3
Guilty feelings	5.7	8.6	14.6	3.2	1.6	3.6	3.5	3.4	-3.1	2.6	1.2	-0.1	3.4	3.8	3.5	2.4	3.1	2.3	3.4	-2.4	3.5	2.7
Breast cancer (self-reported)	5.6	6.7	10.8	-3.3	-2.3	-2.5	-3.2	-2.6	2.6	-2.8	-2.2	-1.4	-2.7	-2.8	-2.0	-2.5	-3.2	-2.9	-2.5	1.6	-2.9	-2.3
Stomach or abdominal pain in last month	5.5	6.8	13.4	2.5	0.6	3.5	2.7	3.6	-3.7	2.2	1.3	-0.1	2.1	3.3	2.6	2.3	2.2	0.9	3.3	-3.1	3.3	2.5
Worry too long after embarrassment	5.4	9.1	18.7	3.1	0.9	4.3	3.0	3.9	-2.0	3.6	1.5	0.1	3.4	3.9	3.6	2.6	3.0	3.0	3.7	-1.8	3.9	1.7
Irritability	5.3	9.0	16.2	3.6	3.7	3.0	2.9	2.7	-2.9	2.9	1.8	2.2	3.2	3.1	3.1	2.4	4.0	2.9	2.9	-1.9	3.0	3.8
Other serious medical condition/disability diagnosed by doctor	5.0	6.5	13.8	3.7	1.7	2.7	2.4	2.6	-2.5	2.3	2.3	1.6	2.5	3.2	1.3	2.7	3.5	2.5	2.6	-1.7	2.7	2.6
Worry (Nagel 2018)	4.8	10.1	21.9	3.5	2.1	3.9	3.7	3.6	-2.8	3.2	0.8	0.6	3.6	4.3	4.7	2.4	3.1	2.6	3.6	-2.4	3.8	2.2
Nervous feelings	4.6	8.6	14.6	3.6	1.9	3.3	3.7	3.4	-2.4	3.3	0.7	0.6	3.6	3.6	3.8	1.9	3.4	2.7	3.2	-1.9	3.3	2.4
Illnesses of mother	4.2	5.2	8.0	-2.5	-0.7	-2.4	-1.4	-2.6	2.6	-2.1	-1.2	-2.6	-2.3	-2.7	-2.1	-2.3	-2.4	-1.7	-2.8	2.0	-2.8	-2.7
Seen a psychiatrist for nerves, anxiety, tension or depression	4.2	5.5	9.6	2.2	2.1	2.8	2.6	3.0	-2.3	2.6	0.9	1.0	2.5	3.1	2.3	1.8	2.3	1.7	2.9	-1.4	3.0	2.3
Diabetes (mother)	4.1	5.3	8.6	2.3	2.5	2.3	1.4	2.5	-1.6	2.9	2.8	2.4	2.2	2.5	1.4	2.8	2.3	1.9	2.8	-0.4	2.7	2.3
Neuroticism (Nagel 2018)	3.9	9.2	15.8	3.2	2.9	3.7	3.1	3.5	-2.6	3.5	1.3	0.6	3.3	3.9	4.0	2.0	3.1	2.5	3.4	-2.1	3.6	2.9
Allergy or Eczema	3.9	10.1	18.1	3.6	2.4	4.3	0.2	3.2	-2.7	3.5	2.2	0.6	2.0	3.6	2.8	3.7	3.6	3.9	3.8	-2.8	3.7	4.2
Heel bone mineral density (BMD) T-score, automated (left)	3.9	9.0	18.4	3.5	2.4	3.3	2.3	3.9	-0.5	4.3	0.9	2.8	3.7	3.3	3.8	1.1	3.5	3.6	3.3	0.5	3.3	2.6
Neuroticism score	3.8	8.0	15.0	2.7	1.7	3.9	3.2	3.3	-2.7	3.4	0.4	-0.2	3.0	3.7	3.5	1.9	2.9	2.1	3.3	-2.2	3.6	2.7
Tense / ‘highly strung’	3.8	6.3	12.5	2.8	0.9	3.1	2.9	3.0	-2.4	2.9	0.8	0.3	2.7	3.4	3.5	1.8	2.6	1.7	3.0	-1.8	3.1	1.7
Shortness of breath walking on level ground	3.7	4.4	9.3	2.2	1.6	2.3	1.4	2.2	-3.0	1.9	0.8	-0.0	1.9	2.2	2.5	2.4	2.1	1.7	2.4	-2.7	2.3	2.1
Waist Hip Ratio (WHR)	3.5	15.6	30.8	3.9	0.9	5.5	2.2	4.6	-3.7	5.2	2.6	1.0	3.3	4.8	4.0	4.5	3.6	3.4	5.2	-3.2	4.8	4.4
Glaucoma (self-reported)	3.5	4.1	9.4	1.4	2.1	2.7	1.3	2.2	-0.7	3.1	1.4	0.6	2.1	2.5	1.5	2.2	1.8	2.0	2.7	-0.4	2.6	2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.5	4.2	8.9	-1.6	-0.9	-2.5	-2.3	-3.0	1.4	-2.1	-2.0	-0.4	-1.9	-2.5	-2.7	-1.8	-2.0	-2.1	-2.6	0.5	-2.2	-2.1
Number of incorrect matches in round	3.4	5.6	15.2	2.0	3.2	2.3	0.7	2.0	-2.0	2.6	2.2	1.4	1.8	2.6	2.2	2.8	1.9	2.9	2.4	-1.9	2.6	3.9
Heel bone mineral density (BMD) T-score, automated (right)	3.1	7.1	12.7	3.0	2.3	3.0	2.3	3.5	-0.4	3.6	0.6	2.6	3.5	3.0	3.5	0.6	2.8	3.2	3.0	0.5	3.0	2.1
Ulcerative Colitis	3.0	4.4	9.3	1.6	1.1	1.7	2.6	2.7	-2.6	1.5	2.2	1.8	2.8	2.2	3.1	1.2	2.0	1.6	2.2	-1.3	2.2	2.0
Neuroticism	3.0	7.2	13.9	2.5	2.0	3.7	2.6	3.1	-2.5	3.2	0.3	-0.1	2.6	3.4	3.3	1.7	2.8	2.1	3.2	-2.3	3.4	2.8
Hayfever, allergic rhinitis or eczema	3.0	6.4	12.8	2.6	1.9	3.3	0.1	2.4	-2.5	2.8	2.0	0.5	1.5	2.7	1.9	3.3	2.6	2.9	3.0	-2.5	3.1	3.6
Health satisfaction	3.0	3.9	7.8	2.0	2.2	2.4	1.7	2.2	-2.8	1.8	1.6	0.2	1.0	2.4	0.5	2.0	1.9	1.2	1.8	-2.5	2.4	2.7
Bipolar Disorder (2011)	2.9	2.8	7.0	1.3	2.5	1.9	0.3	1.8	-0.6	2.1	2.6	1.2	1.1	1.9	0.2	1.3	1.7	2.0	1.7	0.0	1.9	2.4
Eye problems/disorders: None of the above	2.9	3.4	7.3	-1.2	-0.9	-2.6	-0.1	-2.2	1.8	-2.4	-0.2	-0.1	-1.1	-2.3	-2.7	-2.1	-1.4	-1.9	-2.2	1.9	-2.5	-1.8
Ever had hysterectomy (womb removed)	2.8	3.2	7.2	-1.8	-1.4	-1.4	-2.4	-1.9	1.3	-1.4	-1.9	-1.4	-2.7	-1.6	-2.5	-2.5	-1.6	-1.4	-1.9	0.2	-1.6	-1.2
Worrier / anxious feelings	2.8	5.4	12.0	1.9	1.0	2.9	3.2	2.9	-2.6	2.2	0.6	-0.3	2.4	3.1	3.5	1.6	1.4	0.7	3.0	-2.4	3.0	1.4
Medication: Lisinopril	2.8	3.7	7.1	2.4	1.2	1.6	1.9	2.0	0.1	2.5	2.7	2.3	2.5	2.2	1.5	0.9	2.4	2.4	1.6	0.7	2.0	0.9
Heart disease (mother)	2.7	3.3	6.7	1.3	1.6	2.2	-0.6	2.6	-1.7	2.1	1.1	1.2	1.3	2.1	2.0	2.3	1.4	1.3	2.3	-1.4	2.2	2.5
Irritable Bowel Disease (IBD)	2.6	6.2	15.3	2.1	0.8	1.7	3.6	3.3	-2.9	1.6	3.9	2.2	3.0	2.4	2.9	2.7	2.2	1.3	2.8	-1.1	2.5	1.8
Blood White Count	2.6	19.2	38.8	-4.4	-5.1	-4.1	-4.7	-4.5	2.4	-3.9	-4.7	-5.0	-6.2	-4.6	-3.7	-3.1	-5.0	-5.2	-4.7	0.4	-4.9	-3.3
Medication: Atenolol	2.6	3.2	9.1	-2.2	-1.1	-2.0	-0.5	-1.1	1.9	-1.8	-1.1	-1.4	-1.2	-1.9	-1.3	-3.0	-2.3	-2.1	-1.4	1.8	-1.9	-2.4
Lupus	2.5	3.8	8.0	1.9	0.9	2.1	0.7	2.1	-2.0	2.2	0.8	0.3	2.0	2.1	2.8	2.6	2.0	1.6	2.3	-2.0	2.2	2.4
Hair/balding pattern: Pattern 3	2.4	3.6	7.1	-1.7	-0.8	-2.6	-1.0	-1.9	2.7	-1.9	-0.9	-1.2	-1.2	-2.2	-1.8	-2.3	-1.7	-0.9	-2.3	2.5	-2.5	-1.8
Risk taking	2.4	3.5	7.0	2.1	2.6	1.4	1.7	2.1	-2.2	1.2	1.1	2.5	2.0	2.2	2.3	1.4	2.1	1.1	1.8	-1.5	1.8	1.6
Medication: Levothyroxine sodium	2.3	3.9	8.1	-2.5	-1.0	-2.1	-2.1	-1.8	1.1	-2.9	-1.8	-0.7	-1.7	-2.0	-1.6	-2.5	-2.2	-2.8	-1.8	1.0	-2.1	-2.4
Allergy	2.3	5.2	11.5	-2.1	-2.2	-3.0	0.8	-1.8	2.7	-2.2	-1.1	-0.5	-1.1	-2.4	-1.9	-3.0	-2.2	-2.0	-2.6	3.1	-2.7	-3.4
Alcohol intake versus 10 years previously	2.3	3.5	5.8	-2.4	-0.1	-1.9	-1.7	-1.5	1.7	-1.7	-1.5	-0.4	-2.2	-2.2	-2.1	-2.4	-2.4	-2.4	-2.0	1.5	-2.1	-1.3
Medication: Amlodipine	2.3	3.2	7.7	1.5	0.6	1.9	2.3	2.5	-1.2	1.5	0.8	2.8	2.4	1.8	2.6	-0.3	1.6	1.4	2.3	-0.1	2.2	0.7
Illnesses of siblings: Diabetes	2.3	2.8	5.5	1.5	1.8	1.8	1.5	1.8	-1.6	1.8	1.9	2.0	1.8	1.6	0.6	2.3	1.4	1.0	2.1	-0.4	2.0	1.6
Ulcerative Colitis (UC)	2.2	4.1	11.1	1.4	0.5	1.0	2.9	2.5	-3.3	0.6	3.3	1.3	2.4	1.7	2.8	2.0	1.6	0.8	2.1	-1.7	1.7	1.7
HbA1C	2.2	2.4	5.2	-1.5	-0.9	-1.3	-0.9	-1.3	1.3	-2.2	-1.8	-2.3	-1.3	-1.7	-1.3	-1.0	-1.5	-2.0	-1.8	0.2	-1.9	-1.8
Sensitivity / hurt feelings	2.2	3.7	8.1	1.7	0.8	2.7	2.8	2.4	-1.0	2.7	1.1	0.4	2.1	2.1	1.9	1.4	2.2	1.8	2.1	-0.9	2.3	1.7
Age when periods started (menarche)	2.2	5.2	14.5	-2.1	-1.4	-3.6	-2.0	-2.5	0.6	-3.8	-2.5	-0.8	-1.7	-2.5	0.1	-2.6	-2.4	-2.1	-2.6	-0.3	-3.0	-2.5
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	7.2	1.8	1.3	2.7	1.5	2.2	-1.2	2.4	0.2	0.8	1.9	2.5	1.4	1.1	1.8	1.7	2.5	-1.5	2.5	1.9
Time employed in main current job	2.2	2.5	8.1	1.6	1.4	1.6	1.8	2.2	-0.9	2.0	-0.1	0.0	1.1	1.9	2.9	1.9	1.6	1.4	1.6	-0.9	1.7	0.9
Medication: Bendroflumethiazide	2.2	3.4	6.7	1.5	1.3	1.3	2.5	2.5	-0.3	2.3	2.5	2.3	2.6	2.1	2.1	-0.0	1.2	1.6	2.0	1.0	2.0	1.1
Ovarian Cancer	2.1	2.8	6.5	-1.6	0.3	-1.8	-1.3	-2.0	0.6	-1.9	-2.5	-0.3	-1.6	-1.9	-2.0	-2.5	-1.4	-2.2	-1.8	0.2	-1.7	-1.5
Fasting Glucose	2.1	2.6	5.2	-2.3	-0.7	-1.1	-1.5	-2.0	1.3	-1.2	-1.4	-1.4	-2.0	-2.0	-1.4	-1.5	-2.3	-1.6	-1.4	0.9	-1.7	-1.6
Hair/balding pattern: Pattern 4	2.1	5.0	12.9	2.6	1.7	1.9	1.4	2.4	-1.9	2.3	0.7	1.7	1.8	2.7	2.5	2.1	2.6	2.9	2.1	-2.1	1.8	3.6
Mean Putamen Volume	2.0	2.3	5.3	-1.8	-1.4	-2.2	-0.1	-1.4	2.0	-1.4	-0.8	-0.2	-0.6	-1.6	-1.2	-2.3	-1.6	-1.0	-1.6	1.9	-1.6	-1.9
Qualifications: CSEs or equivalent	2.0	2.7	7.9	-1.8	-1.7	-1.9	-0.8	-1.6	2.2	-0.9	-0.3	-0.3	-0.9	-1.8	-1.2	-1.3	-1.8	-1.4	-1.7	2.5	-1.6	-2.8
Diverticular disease/diverticulitis (self-reported)	2.0	2.3	4.8	1.3	0.2	2.2	1.4	2.2	-1.9	1.6	0.7	0.8	1.3	1.8	1.4	1.2	1.6	1.1	2.2	-1.1	2.2	1.0
Illnesses of siblings	2.0	2.8	7.0	-1.1	-2.6	-1.5	-1.6	-2.4	0.9	-1.9	-1.2	-1.7	-1.7	-1.9	-1.6	-1.3	-1.2	-1.1	-2.3	0.0	-1.9	-1.6
Depression (self-reported)	2.0	2.4	5.0	1.9	0.8	2.0	1.0	1.8	-1.1	2.2	1.0	0.4	1.3	1.9	1.0	1.8	2.0	1.8	1.7	-0.5	1.8	1.5
Tinnitus: Yes, but not now, but have in the past	1.9	2.1	5.2	1.8	0.9	1.7	-0.0	1.2	-1.2	1.7	1.1	1.1	1.1	1.9	1.1	0.7	1.9	2.3	1.4	-1.4	1.5	1.9
Medication: Ramipril	1.9	2.4	4.9	-1.6	-1.4	-2.1	0.6	-1.8	2.2	-1.4	-1.4	0.1	-1.1	-2.0	-1.6	-2.1	-1.0	-0.9	-1.7	1.8	-1.8	-1.3
Mouth/teeth dental problems: Bleeding gums	1.9	2.5	4.5	1.9	1.5	1.5	2.1	1.9	-0.7	2.1	1.6	1.2	1.9	1.5	1.7	2.1	1.3	1.2	1.7	-0.4	1.6	0.8
Medication: Allopurinol	1.9	2.6	11.6	-1.7	-1.0	-1.7	-1.1	-1.5	1.9	-1.7	-1.2	1.1	-0.8	-1.3	-0.6	-3.4	-1.6	-1.2	-1.4	2.0	-1.4	-1.9
Suffer from ‘nerves’	1.9	3.0	6.1	1.9	1.3	2.2	2.1	2.0	-1.8	1.7	0.1	-0.3	1.4	2.5	2.2	1.4	1.8	1.4	1.8	-1.4	2.1	1.8
Chest pain or discomfort	1.9	2.8	6.6	1.4	0.9	1.6	2.2	1.8	-2.6	1.4	1.0	0.7	1.6	1.8	1.1	1.6	1.1	0.7	1.8	-2.4	1.7	2.4
Medication: Gliclazide	1.9	2.2	6.4	1.2	0.8	1.7	0.3	1.3	-1.5	1.4	2.0	0.5	1.0	1.3	0.3	2.5	1.3	1.9	1.5	-1.7	1.5	2.1
Crohns Disease (2012)	1.8	2.9	8.4	1.3	0.7	1.6	2.2	2.9	-0.8	1.6	2.5	1.8	1.9	1.9	1.3	1.7	1.4	0.8	2.1	0.8	2.2	0.8
Neuroticism (2016)	1.8	2.5	8.0	1.5	0.4	1.7	2.1	1.6	-2.8	1.1	-0.8	-0.6	1.5	2.0	2.2	0.5	1.3	0.3	1.7	-2.2	1.9	1.3
Supplements: Calcium	1.8	1.9	4.3	1.8	-0.6	1.7	0.6	1.6	-1.8	0.9	-0.7	0.4	0.9	1.8	1.8	1.1	1.8	0.9	1.4	-2.1	1.7	1.1
Lung FEV1/FVC ratio	1.7	8.4	29.0	2.3	5.3	-0.8	2.4	-0.4	3.1	1.6	4.7	5.4	2.9	0.7	-2.4	-0.8	2.2	3.4	-0.4	4.6	0.3	1.4
Medication: Lansoprazole	1.7	1.9	3.8	1.4	0.1	1.9	0.5	1.3	-1.9	0.9	0.9	1.4	1.8	1.7	1.1	0.2	1.7	1.3	1.9	-1.7	2.0	0.7
Pulse wave reflection index	1.7	2.1	4.4	-1.6	-1.5	-1.3	-2.1	-0.9	0.7	-2.1	-1.5	-1.5	-1.6	-1.4	-0.6	-1.4	-1.5	-1.8	-1.3	0.0	-1.6	-1.6
Commuting to job workplace: Car/motor vehicle	1.7	2.0	4.4	1.2	2.1	1.5	1.4	1.7	0.4	1.6	1.8	1.5	1.7	1.3	0.7	0.7	1.3	1.8	1.6	0.9	1.6	-0.1
Average weekly red wine intake	1.7	2.6	7.9	2.0	0.9	1.7	0.3	1.5	-1.0	1.8	2.2	0.7	0.9	2.2	0.8	2.8	1.6	1.6	1.5	-0.9	1.8	1.9
Average weekly champagne plus white wine intake	1.7	2.3	4.9	-1.2	-1.2	-1.8	-1.7	-1.4	1.5	-1.9	-0.6	-1.2	-2.1	-1.7	-1.6	-1.2	-1.3	-0.8	-2.2	0.9	-1.9	-1.7
Reaction Time	1.6	3.1	8.1	1.2	2.0	2.1	-1.0	2.0	-1.9	1.8	0.1	-2.0	-0.3	2.0	2.8	1.8	0.9	1.1	1.7	-2.3	1.6	2.4
Verbal and Numeric Reasoning (VNR)	1.6	3.8	7.1	2.3	-0.1	2.4	1.7	2.5	-2.3	1.6	0.8	-0.6	1.8	2.4	1.7	1.8	2.4	1.6	1.9	-2.4	2.1	2.7
Supplements: Zinc	1.6	1.7	6.3	-1.4	-1.6	-0.3	-2.5	-1.4	-0.3	-0.7	-2.1	-2.2	-2.0	-0.9	-0.3	-0.7	-1.1	-1.0	-1.0	-0.9	-0.9	0.3
Gout (self-reported)	1.6	2.2	8.8	-1.6	-1.3	-1.7	-1.3	-1.4	1.7	-1.7	-1.3	0.4	-0.9	-1.3	-0.6	-3.0	-1.6	-1.1	-1.3	1.4	-1.5	-1.4
Long-standing illness, disability or infirmity	1.6	2.4	5.9	1.0	0.9	2.4	0.1	1.7	-2.2	1.7	0.2	0.5	0.5	1.9	1.2	1.4	1.2	0.2	2.3	-2.0	2.3	2.1
Ever had bowel cancer screening	1.6	1.9	3.6	1.7	-0.5	1.8	1.4	1.1	-1.3	1.5	1.3	1.4	0.8	1.7	1.2	1.1	1.8	1.2	1.8	-0.8	1.9	1.0
Back pain experienced in last month	1.6	2.3	5.0	1.4	2.2	1.9	1.0	1.8	-1.9	1.8	0.6	0.4	0.8	1.8	1.0	1.7	1.3	0.9	1.8	-1.8	1.9	1.5
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	8.0	1.9	0.6	1.1	0.8	1.2	-2.8	0.2	-0.1	1.0	1.2	1.1	0.5	1.2	1.8	0.5	1.4	-2.5	1.5	1.4
Crohns Disease (2017)	1.5	3.2	7.4	1.5	0.4	1.4	2.7	2.7	-1.1	1.6	2.7	1.9	2.0	1.6	1.8	2.6	1.5	0.8	2.1	0.1	1.9	0.7
Prostate Cancer	1.5	2.2	4.0	-2.0	-1.4	-1.1	-0.2	-1.7	1.1	-2.0	-1.2	-1.5	-1.1	-1.3	-1.3	-1.4	-1.5	-2.0	-1.6	0.8	-1.5	-1.9
Medication: Ventolin 100micrograms inhaler	1.5	1.9	9.5	1.4	0.3	1.5	-0.3	1.2	-2.8	0.6	-0.1	-0.4	0.4	1.4	0.8	1.3	1.1	0.6	1.2	-3.1	1.3	1.7
Qualifications: nursing, teaching	1.5	2.3	4.3	1.6	1.5	1.6	2.0	1.5	-1.1	1.4	1.2	1.9	2.1	1.7	1.2	1.0	1.7	1.4	1.5	-0.5	1.7	1.4
Tinnitus: Yes, now most or all of the time	1.5	1.7	6.2	-1.0	-1.1	-1.5	-0.8	-1.5	-0.2	-1.4	-0.8	-0.8	-1.4	-1.3	-2.5	-2.1	-1.1	-1.4	-1.8	-0.1	-1.0	-0.9
Eye problems/disorders: Glaucoma	1.5	1.8	6.0	0.2	1.5	1.9	0.4	1.7	0.7	2.4	0.8	0.4	1.0	1.8	0.8	1.1	0.6	1.3	1.7	0.9	1.9	1.7
Alcohol drinker status: Previous	1.5	1.7	4.9	2.2	1.3	1.1	0.6	0.6	-0.9	1.4	-0.1	-0.3	0.5	1.4	2.0	1.7	2.2	1.4	0.7	-1.3	0.8	1.5
LDL Cholesterol	1.4	2.1	5.0	-1.3	-1.3	-1.7	-2.2	-1.8	0.9	-1.3	-1.6	-1.0	-1.8	-1.9	-1.1	-1.1	-1.4	-1.6	-1.5	0.5	-1.8	-0.5
Falls in the last year	1.4	1.9	4.6	1.2	1.8	1.7	1.0	1.4	-2.1	1.0	1.2	0.6	0.7	1.5	-0.1	1.2	1.1	0.4	1.6	-2.1	1.6	1.7
Mean time to correctly identify matches	1.4	2.6	6.5	0.9	2.2	1.9	-1.6	1.7	-1.4	1.7	-0.0	-1.3	-0.5	1.8	2.6	1.3	0.8	1.1	1.7	-2.0	1.5	2.3
Had major operations	1.4	1.6	5.2	0.9	-0.4	2.3	-0.7	1.1	-1.5	1.2	-0.6	-1.1	-0.5	2.2	1.6	1.1	0.2	0.1	1.4	-1.8	1.7	0.9
Had other major operations	1.3	1.6	5.1	-1.1	-1.4	-0.8	-1.8	-1.5	0.6	-0.8	-2.3	-0.8	-1.5	-1.2	-1.3	-1.8	-1.2	-1.2	-1.3	-0.4	-1.2	-0.6
Heart attack	1.3	1.6	4.7	-1.8	0.5	-1.4	-0.5	-0.8	1.1	-1.2	-0.4	-2.2	-1.5	-1.4	-1.3	-0.2	-1.8	-1.8	-1.2	0.5	-1.6	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	4.3	0.8	0.0	2.1	1.6	1.5	-1.9	1.5	-0.0	-0.5	1.3	1.4	1.4	1.4	1.1	0.9	1.9	-1.6	1.9	1.2
Diabetes diagnosed by doctor	1.3	2.1	6.1	1.3	0.3	2.1	-0.4	1.5	-2.1	1.5	0.6	-0.3	0.4	1.4	0.7	2.1	1.1	0.8	1.4	-2.5	1.7	2.1
Osteoporosis (self-reported)	1.3	1.6	5.1	-1.2	-0.9	-1.4	-1.3	-0.6	-0.5	-1.9	0.1	-2.3	-1.7	-1.4	-0.5	0.1	-1.1	-1.5	-1.3	-1.2	-1.5	-0.6
Medication: Co-codamol	1.2	1.4	4.6	-1.2	-1.2	-0.8	-1.9	-0.6	-0.1	-1.1	-1.7	-0.5	-1.1	-0.6	-1.0	-2.1	-1.4	-1.8	-0.6	-0.8	-0.7	-0.9
Average weekly fortified wine intake	1.2	1.5	5.6	-1.6	-2.4	-0.6	-0.3	-1.4	0.9	-0.8	-0.5	-1.7	-0.7	-0.8	-1.1	-0.8	-1.9	-1.5	-0.6	0.5	-0.7	-1.5
High blood pressure	1.2	3.3	11.0	1.5	1.6	0.7	3.3	2.8	-0.6	1.1	1.4	2.2	2.7	1.9	2.8	-1.5	1.3	1.6	1.8	0.5	1.4	0.6
Hair/balding pattern: Pattern 2	1.2	1.5	5.7	1.0	0.4	1.6	0.1	1.0	-2.3	0.9	1.0	0.7	0.4	1.1	0.4	2.4	0.8	0.1	1.2	-2.0	1.7	0.6
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	4.2	1.4	-0.1	1.6	-0.3	0.7	-2.0	1.3	0.3	-0.4	0.5	1.2	0.2	1.7	1.2	1.5	1.0	-2.0	1.6	1.9
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	4.1	0.9	1.3	1.9	0.6	1.7	-1.8	1.3	-0.4	-0.7	0.7	1.7	1.9	0.7	0.5	-0.0	2.0	-2.0	1.6	1.5
Qualifications: College or University degree	1.2	3.9	8.3	2.7	0.5	2.1	2.2	1.7	-1.8	1.6	1.3	1.4	2.5	2.4	1.7	2.9	2.2	2.0	1.9	-1.7	2.0	1.5
Hearing aid user	1.2	1.3	5.1	-1.1	-0.5	-1.3	-1.4	-1.2	1.1	-0.9	-0.4	-1.4	-2.3	-1.2	-1.4	-0.7	-0.7	-0.6	-1.3	0.6	-1.4	-0.5
Cholesterol lowering medication	1.2	1.7	3.3	-1.8	-1.3	-1.0	-1.1	-0.6	0.4	-1.2	-1.8	-1.4	-1.8	-0.9	-1.7	-1.6	-1.6	-1.8	-1.3	-0.3	-1.1	-0.7
Impedance of leg (right)	1.1	5.2	21.0	3.2	-0.7	2.0	1.4	2.1	-4.0	0.5	-0.2	0.8	1.8	2.5	2.7	1.9	2.2	1.2	2.0	-4.6	2.4	1.4
Father’s age at death	1.1	1.5	4.8	1.1	0.4	1.9	-1.1	0.7	-1.1	1.4	-0.7	-0.1	0.5	1.2	0.5	1.2	1.2	1.4	1.1	-1.7	1.3	2.2
High blood pressure (siblings)	1.1	1.6	4.8	0.4	2.2	1.0	1.1	1.9	-0.2	1.9	-0.1	1.2	1.3	1.4	1.7	-0.2	0.9	0.5	1.6	0.9	1.5	1.2
Wheeze or whistling in the chest in last year	1.1	1.9	8.0	0.7	0.6	1.4	-0.1	1.2	-2.8	0.8	0.6	0.3	0.3	1.4	1.4	1.5	0.4	-0.1	1.7	-2.7	1.5	2.1
Overall health rating	1.1	2.3	7.5	1.0	0.9	2.0	1.8	1.8	-2.7	1.2	-0.0	0.2	0.8	1.5	0.6	1.1	1.0	-0.3	1.8	-2.3	1.9	2.1
Hypertension (Self-reported)	1.1	3.1	10.6	1.4	1.6	0.7	3.3	2.8	-0.5	1.1	1.2	1.9	2.6	1.8	2.8	-1.4	1.1	1.5	1.8	0.5	1.3	0.6
Osteoarthritis (self-reported)	1.1	1.4	7.8	-1.0	0.1	-0.7	-0.6	-0.6	1.6	-0.5	-2.2	0.8	-0.4	-1.1	-0.8	-2.8	-0.2	-0.4	-0.6	1.8	-0.7	-1.1
Illnesses of father: None of the above (group 1)	1.1	1.3	3.0	1.2	1.2	0.9	0.5	0.5	0.7	1.2	1.6	1.7	1.7	1.1	1.1	0.3	1.4	1.3	1.3	1.3	1.0	-0.2
Ever taken oral contraceptive pill	1.1	1.2	5.1	-1.6	-2.2	-0.5	0.5	-0.7	0.4	-0.9	-0.2	-1.5	-0.7	-1.0	-0.8	-0.6	-1.7	-1.7	-0.5	0.9	-0.7	-1.2
Height	1.0	20.0	41.5	5.5	4.0	3.6	3.2	3.5	-4.4	2.7	4.8	1.6	4.7	4.1	3.8	6.4	6.2	5.9	3.8	-3.6	3.3	6.3
Systolic Blood Pressure	1.0	5.1	22.3	2.5	1.1	0.6	3.7	2.7	0.6	1.7	2.1	4.7	3.5	1.8	2.0	-1.5	2.0	2.2	1.5	1.7	1.5	0.6
Type 2 Diabetes (T2D) (2018)	1.0	1.9	5.9	1.0	0.2	2.2	0.2	1.4	-2.2	1.5	0.2	0.2	0.8	0.9	1.0	1.7	0.9	0.7	1.6	-2.4	1.8	1.6
Hearing difficulty/problems: Yes	1.0	1.6	8.5	-1.5	0.7	-1.6	-0.1	-0.9	1.1	-1.1	1.0	-0.0	-0.9	-1.3	-2.9	-1.4	-0.6	-0.2	-1.5	1.6	-1.1	-0.8
Townsend deprivation index at recruitment	1.0	1.4	3.9	-0.8	-1.1	-1.5	0.1	-1.6	1.2	-1.0	-0.1	0.3	-0.8	-1.3	-2.0	-1.4	-0.7	-0.9	-1.5	1.2	-1.5	-0.7
Mouth/teeth dental problems: Dentures	1.0	1.7	4.2	-1.1	-2.0	-1.1	-1.2	-1.5	0.2	-1.5	-1.9	-0.4	-1.5	-1.0	-1.4	-1.6	-1.3	-1.8	-0.9	-0.0	-1.1	-1.0
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	5.0	-1.5	-0.4	-1.1	-2.2	-1.4	0.1	-2.1	-1.8	-0.2	-1.2	-1.4	-0.4	-1.8	-1.5	-2.1	-0.9	-0.1	-1.3	-1.2
Emphysema/chronic bronchitis	1.0	1.2	5.9	0.7	-0.5	0.4	-0.0	0.5	-2.0	-0.3	-1.3	-1.3	0.2	0.7	2.4	0.9	0.9	-0.2	0.6	-2.0	0.4	1.0
Pulse rate, automated reading	1.0	3.1	6.3	1.7	0.3	2.2	2.5	1.6	-2.3	2.0	0.7	0.5	1.8	2.1	1.0	2.4	1.2	0.8	2.2	-2.0	2.3	1.5
High cholesterol (Self-reported)	1.0	1.8	4.5	-1.5	-1.5	-1.5	-0.7	-0.8	0.5	-1.6	-1.4	-0.5	-1.6	-1.3	-2.1	-1.9	-1.4	-1.7	-1.4	0.3	-1.2	-1.4
Heart attack/myocardial infarction (self-reported)	1.0	1.3	4.2	-1.6	0.5	-1.2	-0.4	-0.7	1.0	-1.0	-0.5	-2.0	-1.3	-1.3	-1.0	-0.0	-1.7	-1.7	-1.0	0.4	-1.5	-0.5
Lung FVC	0.9	4.4	11.2	-1.5	-2.1	-2.6	-0.6	-2.3	1.8	-2.7	-2.6	0.4	-0.6	-2.1	-1.7	-3.4	-1.4	-2.1	-2.2	1.9	-1.9	-3.0
Tanning	0.9	10.4	16.8	-2.9	-2.7	-3.6	-2.7	-3.9	3.0	-3.0	-2.5	-1.7	-3.3	-3.6	-3.4	-3.7	-3.1	-3.2	-3.9	2.5	-3.5	-4.1
Multivitamins +/- minerals	0.9	1.2	4.6	1.0	0.0	1.4	-0.3	0.3	-1.2	0.8	-1.8	-1.6	-0.2	1.0	1.5	0.4	0.6	0.6	0.8	-2.1	0.7	1.5
Fluid intelligence score	0.9	1.9	5.5	1.1	-0.4	1.8	0.3	1.8	-2.2	0.6	0.4	0.1	0.9	1.7	1.4	1.0	1.2	0.5	1.3	-2.3	1.6	1.9
Impedance of arm (right)	0.9	4.3	11.1	3.0	-0.2	2.2	1.7	1.5	-2.6	1.2	-0.2	1.8	2.6	2.2	2.9	1.3	2.0	1.7	2.2	-3.3	2.3	0.8
Exposure to tobacco smoke outside home	0.9	1.1	2.9	1.3	1.4	0.8	-1.1	0.4	-0.4	1.0	1.2	0.9	0.5	1.1	1.0	1.7	1.4	1.5	0.6	-0.7	0.7	1.2
Leg pain on walking	0.9	1.2	3.5	1.8	1.2	1.3	0.3	0.7	-0.6	1.0	0.8	0.8	0.9	1.1	0.5	0.6	1.9	1.4	1.1	-0.7	1.1	1.4
Number of operations (self-reported)	0.9	1.3	5.2	0.9	0.6	2.3	0.0	1.1	-0.6	2.1	-0.2	1.1	0.2	1.7	0.4	-0.0	0.9	0.9	1.2	-0.9	1.6	1.2
Average weekly beer plus cider intake	0.9	1.4	6.1	-0.4	-1.0	-0.8	-1.4	-0.6	-0.7	-1.2	-2.5	-2.0	-0.8	-0.9	0.8	-0.9	-0.6	-1.7	-0.7	-1.1	-1.1	-0.5
Vascular/heart problems diagnosed by doctor	0.9	2.5	9.4	-1.2	-1.6	-0.4	-3.1	-2.7	0.9	-0.8	-1.3	-1.5	-2.0	-1.7	-2.2	1.4	-1.0	-1.1	-1.6	-0.2	-1.2	-0.9
Impedance of whole body	0.9	4.4	12.3	3.1	-0.5	1.9	1.9	1.7	-3.2	0.8	-0.5	1.5	2.3	2.2	3.0	1.2	2.2	1.4	2.0	-3.5	2.3	0.6
Intelligence (Savage-Jansen 2018)	0.8	2.3	5.8	2.1	0.4	1.9	0.6	1.7	-1.8	1.0	0.6	-0.1	1.0	2.2	1.2	1.3	1.8	1.4	1.2	-2.4	1.4	2.4
Body Mass Index (BMI) (2010)	0.8	1.1	7.8	-1.4	-0.1	-0.1	-0.7	-1.2	1.1	0.1	0.9	-0.1	-1.1	-0.9	-2.8	-1.2	-1.1	-0.5	-0.6	1.2	-0.2	-0.1
Blood Eosinophil Count	0.8	5.9	16.2	-2.8	-0.2	-2.1	-4.0	-3.2	2.1	-1.8	-1.2	-0.8	-3.5	-2.6	-3.4	-2.1	-3.0	-2.4	-2.6	1.1	-2.4	-0.8
Respiratory disease	0.8	1.8	8.9	0.3	-0.2	1.5	-1.5	1.2	-2.1	-0.3	-0.6	-1.9	-0.8	1.1	1.6	1.7	0.2	-0.6	0.9	-3.0	0.8	1.3
Vitamin and mineral supplements	0.8	1.1	5.9	-0.3	0.7	-0.7	0.6	-0.1	1.2	0.1	2.1	2.4	0.9	-0.2	-1.4	0.0	-0.1	0.5	-0.0	2.2	0.0	-0.5
Taking other prescription medications	0.8	1.2	7.7	-0.3	-0.6	0.7	-1.1	-0.0	-2.1	-0.9	-2.1	-0.4	-0.5	0.3	0.3	-0.4	-0.4	-1.3	0.5	-2.8	0.5	0.2
High blood pressure (mother)	0.8	1.1	2.7	1.1	-0.2	1.1	0.6	1.2	-1.4	0.8	0.6	1.3	1.3	1.4	1.3	0.4	0.7	0.3	1.7	-0.8	1.5	0.6
Impedance of leg (left)	0.8	3.7	19.6	2.4	-1.0	1.5	1.0	1.4	-4.1	-0.0	-1.0	0.4	1.1	1.8	2.5	1.3	1.6	0.4	1.5	-4.4	2.0	0.8
Trunk fat mass	0.8	3.3	12.2	1.8	2.3	2.4	-0.8	1.2	-1.1	2.6	1.9	0.6	0.3	1.3	-0.5	2.2	2.2	2.2	1.4	-0.9	1.6	3.5
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.8	1.5	0.1	0.9	0.8	0.2	-1.5	0.4	0.5	0.7	1.1	0.9	0.2	1.1	1.1	0.6	1.0	-1.7	1.0	0.7
Birth weight of first child	0.8	1.4	3.5	0.6	0.7	1.3	0.7	1.7	-0.4	1.9	1.1	0.6	1.4	1.5	1.4	1.3	0.5	1.5	1.5	-0.1	1.4	1.3
Leg fat percentage (right)	0.8	2.8	9.2	1.4	2.0	2.5	-1.3	1.4	-1.0	2.7	1.4	0.2	-0.1	1.5	-0.9	1.7	1.5	1.6	1.6	-1.2	1.9	3.0
Number of children fathered	0.8	0.9	4.1	-1.0	0.3	-0.1	-1.5	-1.3	0.2	-0.5	0.0	0.9	-1.1	-0.6	-2.0	-1.3	-1.4	-1.2	-0.5	0.3	-0.2	-0.7
Supplements: Vitamin C	0.8	1.0	5.0	-0.6	-2.0	-0.4	-0.5	-0.2	0.0	-0.1	-0.6	-2.2	-1.6	-0.9	-0.4	-0.3	-0.3	-1.0	-1.1	-0.4	-0.7	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	4.2	-0.9	-0.1	0.3	-2.0	-0.4	-0.5	-0.6	-1.8	-2.1	-1.0	-0.5	-0.6	-0.4	-0.7	-0.5	-0.3	-1.5	-0.4	0.5
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	5.0	1.5	0.2	1.3	-0.0	0.9	-1.8	1.1	-1.0	-0.6	0.3	1.0	0.5	0.2	1.3	1.1	0.8	-2.2	1.1	1.6
Diastolic blood pressure, automated reading	0.8	2.4	11.8	-1.0	-0.5	-1.8	1.1	-0.6	2.4	-0.8	0.5	1.9	0.3	-1.2	-1.4	-3.4	-1.0	-0.1	-1.3	2.7	-1.4	-1.6
Myopia	0.8	1.1	3.0	1.7	-0.5	1.5	0.6	0.8	-1.4	0.8	0.6	0.8	1.0	1.7	0.8	0.7	0.9	0.7	1.2	-1.2	1.4	0.9
Alzheimer’s Disease (in mother)	0.7	0.9	2.8	0.3	-0.8	0.9	0.3	1.1	-1.4	0.3	-1.4	-0.8	-0.0	0.7	1.6	1.3	0.4	-0.4	0.9	-1.7	0.7	0.1
Systolic blood pressure, automated reading	0.7	2.0	13.9	0.9	0.3	-0.1	1.5	1.0	1.7	1.1	1.0	3.7	1.4	0.4	-0.5	-2.4	0.7	1.5	0.3	2.0	0.3	-0.1
Trunk fat percentage	0.7	2.8	8.3	1.8	1.8	2.5	-0.6	1.3	-1.2	2.6	1.4	0.6	0.3	1.4	-0.2	1.7	2.0	1.9	1.5	-1.1	1.7	2.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	7.4	1.7	1.9	-0.3	2.4	0.5	1.1	0.3	2.1	2.7	2.6	0.5	0.1	0.3	1.7	1.4	0.0	2.6	0.2	0.0
Impedance of arm (left)	0.7	3.2	8.5	2.9	-0.2	1.6	1.9	1.3	-1.9	1.0	-0.2	2.3	2.6	1.8	2.5	0.7	2.1	1.7	1.7	-2.2	1.9	0.5
Body fat percentage	0.7	2.9	9.7	1.7	2.1	2.5	-1.2	1.3	-1.2	2.8	1.1	0.5	0.0	1.4	-0.3	1.6	1.8	1.8	1.6	-1.2	1.8	3.1
Whole body fat mass	0.7	3.1	12.7	1.6	2.4	2.2	-1.3	1.1	-0.9	2.6	1.8	0.3	0.0	1.2	-0.6	2.3	2.0	2.1	1.3	-0.8	1.4	3.6
Leg fat mass (right)	0.7	2.6	12.0	1.2	2.2	2.0	-1.3	1.0	-1.1	2.2	1.8	0.1	-0.1	1.1	-0.9	2.2	1.5	1.6	1.2	-1.0	1.3	3.5
Medication: Aspirin	0.7	0.9	3.7	0.4	1.2	1.2	-0.2	1.0	-1.4	1.1	0.8	0.3	0.3	0.8	-0.8	0.7	0.5	0.6	1.0	-1.1	1.3	1.9
Eye problems/disorders: Cataract	0.7	0.8	4.5	0.7	-0.3	0.6	0.7	0.7	-1.9	0.0	-0.3	0.0	0.3	0.4	1.1	0.6	1.1	1.0	0.5	-2.1	0.6	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	5.2	-0.5	-0.2	-1.4	1.3	-0.9	1.8	-1.3	0.2	0.9	0.1	-0.6	-0.8	-1.7	-0.7	-1.1	-1.3	2.3	-1.1	-2.1
Commuting to job workplace: Public transport	0.7	0.8	3.6	-0.6	-0.7	-1.3	-1.9	-1.1	0.7	-0.6	-0.6	0.1	-1.5	-0.8	-0.8	-0.2	-0.6	-0.3	-1.3	0.2	-1.1	-0.4
Commuting to job workplace: Cycle	0.7	0.8	2.3	-0.2	-1.5	-1.3	0.3	-0.9	1.1	-0.8	0.8	-0.0	-0.3	-0.4	-0.8	-1.2	-0.6	-0.6	-1.1	1.5	-0.8	-1.3
Pack years of smoking	0.7	1.0	3.1	0.7	-0.4	1.4	1.8	1.1	-0.8	1.4	0.9	-0.4	1.0	1.3	0.7	0.7	0.8	0.5	1.2	-0.4	1.4	0.9
Schizophrenia (2018)	0.6	1.2	3.3	0.8	1.3	1.0	0.5	1.8	-1.1	1.3	1.3	0.8	1.2	1.0	1.2	1.5	0.8	0.6	1.3	-0.6	1.4	0.9
Alzheimer’s Disease (in father)	0.6	0.7	2.1	0.6	0.1	1.0	0.5	0.8	0.1	1.4	-0.1	-1.1	0.4	0.8	0.9	1.4	0.6	0.3	0.9	-0.1	0.7	1.2
Rheumatoid Arthritis	0.6	0.9	3.7	0.8	0.4	0.7	0.7	1.1	-0.9	0.6	1.9	0.0	0.6	1.2	0.5	1.2	0.8	1.1	0.7	-0.6	0.8	1.5
Schizophrenia (2014)	0.6	1.4	3.3	0.9	1.2	1.1	0.8	1.7	-1.3	1.2	1.3	0.4	1.0	1.1	1.0	1.8	1.0	0.6	1.1	-1.0	1.3	1.7
Average weekly spirits intake	0.6	0.7	5.8	-0.6	1.2	0.4	0.8	0.7	-0.0	0.1	2.4	-0.1	-0.0	0.4	-0.7	1.5	-0.7	-0.4	0.6	0.8	0.8	-0.1
Medication: Metformin	0.6	0.8	1.8	0.5	0.4	1.3	0.7	0.7	-0.6	1.3	1.1	0.5	0.8	0.6	-0.4	1.2	0.8	1.2	0.8	-0.5	1.1	1.3
Fed-up feelings	0.6	1.1	3.1	-1.2	-0.2	-1.3	0.7	-1.0	1.0	-0.9	-1.2	-0.8	-0.6	-1.1	-1.1	-1.8	-0.7	-1.0	-1.2	1.2	-1.2	-1.1
Relative age voice broke	0.6	0.9	3.3	-0.3	-1.3	-0.9	0.3	-0.6	-0.1	-1.5	-0.9	-1.0	-1.0	-0.7	-0.3	-1.2	-0.3	-1.1	-1.1	-0.2	-0.9	-1.8
Pain all over the body in last month	0.6	0.6	3.2	0.2	0.6	0.1	-1.2	0.1	-0.1	0.5	1.8	1.4	0.4	0.1	-1.7	0.4	0.5	0.4	0.4	0.3	0.7	0.7
Arm fat percentage (right)	0.6	2.3	9.3	1.3	1.9	2.3	-1.1	0.8	-0.0	3.0	1.1	0.5	-0.1	1.1	-0.7	1.6	1.4	1.8	1.3	-0.3	1.4	2.7
Pulse rate	0.6	0.9	5.2	0.9	-0.2	0.7	2.3	0.2	-1.3	0.4	0.6	0.5	1.8	0.9	0.7	0.4	0.5	0.7	0.9	-1.3	0.9	0.4
Arm fat mass (right)	0.6	2.3	10.2	0.8	2.4	1.8	-1.4	0.7	-0.2	2.5	1.8	-0.0	-0.4	0.8	-1.1	2.1	1.4	1.8	0.8	-0.2	0.9	3.2
Standing height	0.6	6.0	17.0	3.0	1.7	1.2	1.9	1.2	-2.3	0.6	3.8	1.3	3.0	1.5	1.4	4.1	3.7	3.4	1.5	-1.3	1.1	3.6
Ever highly irritable/argumentative for 2 days	0.6	0.8	3.6	-0.7	-1.3	-0.7	-0.3	-1.0	0.2	-0.7	-0.8	0.1	-1.1	-1.0	-1.9	-0.8	-0.5	-1.2	-1.0	-0.3	-0.6	-0.4
Medication: Omeprazole	0.6	0.8	4.1	1.2	0.4	0.6	0.1	0.4	-1.9	-0.2	-0.8	0.3	0.6	0.5	-0.0	0.9	1.0	-0.0	0.6	-2.0	0.6	0.8
Age at last live birth	0.6	0.8	2.0	1.3	1.0	0.7	0.1	0.9	-0.2	0.5	1.2	1.1	1.4	0.7	1.0	0.9	0.7	1.4	1.1	-0.6	0.5	0.6
Illnesses of father: Heart disease	0.6	0.9	6.7	0.3	-0.3	0.6	-0.1	0.3	-2.2	-0.3	-1.1	-0.6	-0.6	0.5	-0.2	0.8	-0.3	-0.3	0.3	-2.6	0.4	0.7
Smoking status: Previous	0.6	0.9	4.6	-0.1	-0.5	-0.6	-2.1	-1.6	0.3	-1.2	0.1	1.0	-1.1	-0.9	-1.8	-0.6	0.0	-0.2	-0.7	-0.1	-0.5	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	5.2	0.7	0.7	0.2	2.2	-0.5	0.5	0.6	2.3	1.4	2.0	-0.0	-0.1	0.6	1.1	1.3	0.3	2.0	0.2	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.0	-0.4	-0.1	-1.2	1.0	-0.6	0.2	-1.4	0.1	0.5	0.0	-1.2	-1.0	-0.8	-0.7	-1.0	-0.8	0.4	-0.8	-1.1
Medication: Aspirin	0.6	0.8	2.9	0.5	0.8	1.1	-0.5	0.9	-1.5	1.0	0.4	0.1	0.0	0.6	-0.7	0.6	0.5	0.5	0.8	-1.4	1.1	1.7
Financial situation satisfaction	0.6	0.7	2.2	-0.2	0.1	1.1	0.6	0.4	-0.3	1.5	1.4	-0.4	0.5	0.8	1.0	1.4	0.2	0.4	1.0	-0.1	1.1	1.0
Illnesses of father: High blood pressure	0.6	0.7	4.5	0.2	-1.4	-0.3	0.1	0.5	-1.7	-0.2	-0.8	-0.9	-0.7	-0.4	0.2	0.6	0.1	-0.1	-0.5	-2.1	0.0	1.2
Leg fat percentage (left)	0.6	2.2	7.5	1.0	2.0	2.3	-1.4	1.1	-1.1	2.5	1.1	0.1	-0.4	1.1	-0.9	1.4	1.1	1.1	1.4	-1.1	1.7	2.7
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.7	0.8	-1.3	0.6	1.3	1.1	-0.3	0.5	1.2	-0.9	0.2	1.2	0.9	0.4	0.4	1.0	0.7	-0.8	0.7	-0.3
Fractured/broken bones in last 5 years	0.6	0.8	2.7	-1.1	-0.6	-0.6	1.0	-0.2	1.0	-0.5	-0.3	0.6	-0.2	-0.7	-1.4	-1.6	-0.8	-0.7	-0.6	1.1	-0.3	-1.4
Ever depressed for a whole week	0.6	0.7	3.3	-1.1	-1.7	0.1	0.9	0.3	-0.7	-0.2	-1.0	-1.8	-0.8	-0.5	-0.1	-0.1	-0.6	-1.1	-0.4	-0.9	-0.3	-0.1
Leg fat mass (left)	0.6	2.4	11.4	1.0	2.3	1.9	-1.4	0.9	-1.2	2.2	1.6	0.1	-0.3	0.9	-0.9	2.1	1.4	1.5	1.1	-0.9	1.2	3.4
Major Depression (MDD)	0.5	0.6	1.5	0.4	0.7	1.2	0.6	0.6	-1.2	0.5	0.8	-0.1	0.4	1.2	-0.1	-0.0	0.4	0.6	0.8	-1.0	1.0	0.7
Breast Cancer	0.5	1.3	3.6	1.1	0.9	1.6	-0.4	1.4	0.1	1.9	0.3	0.6	0.7	1.0	1.4	0.7	1.3	1.4	1.4	0.1	1.4	1.3
Hypothyroidism (self reported)	0.5	1.1	2.8	-1.2	-0.7	-0.9	-1.6	-1.0	-0.0	-1.7	-1.1	0.2	-1.2	-1.3	-1.0	-1.3	-1.1	-1.4	-0.9	-0.3	-1.0	-0.6
Medication for hormone replacement therapy	0.5	0.5	2.3	0.5	-1.5	0.2	-0.5	-0.2	-0.6	-0.1	-1.2	-1.2	-0.6	0.1	1.2	0.2	0.5	-0.3	-0.4	-1.0	-0.2	0.2
Diabetes (father)	0.5	0.6	3.2	0.4	0.6	0.5	0.7	0.6	-1.6	0.3	-1.0	-0.2	0.1	0.2	0.3	0.3	0.2	0.6	0.1	-1.8	0.5	1.2
Pack years adult smoking proportion	0.5	0.8	4.1	0.7	-0.5	1.2	2.0	0.9	-0.6	1.3	0.9	-0.4	0.9	1.1	0.6	0.5	0.7	0.3	1.0	-0.2	1.1	0.6
Hand grip strength (right)	0.5	1.4	4.3	-0.7	0.1	-1.9	-0.5	-1.5	1.5	-1.2	-0.6	0.1	-1.0	-1.6	-0.9	0.3	-0.6	-0.3	-1.9	1.2	-2.1	-1.0
Maternal smoking around birth	0.5	0.7	1.8	-0.8	-0.8	-0.8	1.2	-0.7	0.2	-0.6	0.4	-0.1	-0.2	-0.6	-1.2	-0.5	-1.0	-1.3	-0.9	1.3	-0.6	-1.1
Waist circumference	0.5	1.7	7.1	0.3	1.1	1.8	-1.8	0.8	-0.7	2.0	1.3	-0.9	-0.8	0.6	-0.9	1.8	0.6	0.8	1.1	-0.8	0.9	2.7
Hearing difficulty/problems with background noise	0.5	0.9	4.4	-0.5	-0.4	-0.9	0.1	-0.9	0.8	-0.8	0.2	0.7	-0.3	-0.8	-2.1	-1.9	0.1	-0.1	-1.0	1.1	-0.6	-1.1
Had menopause	0.5	0.6	1.4	0.4	1.0	1.1	-0.2	0.9	0.1	1.2	-0.3	0.1	-0.1	1.0	0.6	0.2	0.9	1.0	0.9	-0.1	1.0	1.1
Diabetes (self-reported)	0.5	0.8	2.7	0.3	-0.5	1.7	-0.5	0.7	-1.1	1.2	0.2	-0.5	-0.2	0.6	-0.2	1.5	0.4	0.3	0.8	-1.6	1.2	1.0
Weight	0.5	2.4	10.8	0.8	2.4	1.3	-1.0	0.6	-0.2	1.9	2.7	-0.1	0.0	0.5	-1.1	2.5	1.6	1.9	0.7	0.4	0.6	3.3
Hip circumference	0.5	2.0	7.9	-1.4	1.0	-0.9	-2.5	-1.2	1.0	-0.6	0.6	-1.3	-2.3	-1.6	-2.8	0.3	-1.1	-0.7	-1.4	0.9	-1.6	0.8
Asthma	0.5	0.9	3.8	-0.8	-0.1	0.6	-1.7	0.1	-1.3	-0.7	-0.9	-1.6	-1.1	0.1	0.6	0.6	-0.6	-1.2	0.2	-1.9	-0.0	0.7
Peak expiratory flow (PEF)	0.5	1.2	5.5	-0.8	0.7	-1.1	-1.6	-1.1	1.9	-0.1	-0.3	1.0	-0.1	-0.8	-1.3	-1.0	-0.6	0.1	-1.1	2.3	-1.0	-0.1
Headache pain in last month	0.5	0.9	3.1	-1.2	-0.9	-0.7	1.5	-0.7	-0.9	-0.9	-0.8	-0.4	-0.0	-1.1	0.6	-0.2	-0.9	-1.8	-0.6	-0.3	-0.5	-1.4
Forced vital capacity (FVC), Best measure	0.5	1.6	5.6	1.6	1.2	-0.1	2.2	0.8	0.0	0.1	1.7	2.1	2.4	0.6	1.0	0.9	1.7	1.0	0.4	1.6	0.4	0.3
Age at first live birth	0.5	0.9	2.5	1.3	0.3	1.0	0.7	1.0	-0.8	0.1	0.6	0.2	1.6	1.0	1.5	1.3	0.9	1.1	1.2	-1.0	0.7	0.4
Mouth/teeth dental problems: Loose teeth	0.5	0.5	2.4	1.2	-0.8	0.4	-0.6	0.6	-0.3	0.8	0.1	-0.2	-0.0	0.6	1.5	1.5	0.8	0.1	0.5	-0.7	0.3	0.4
Medication: Blood pressure	0.5	0.8	4.6	0.4	0.1	-0.0	2.1	1.1	0.7	0.7	0.6	1.2	1.2	0.3	0.5	-1.4	0.5	0.7	0.5	1.2	0.5	-0.2
Number of full sisters	0.5	0.7	2.4	-1.2	0.4	-1.2	-1.6	-0.1	0.0	-0.6	0.0	0.2	-1.4	-0.5	-0.6	-0.3	-1.2	-1.0	-0.6	0.5	-0.5	-0.9
Arm fat percentage (left)	0.5	2.1	8.6	1.2	2.0	2.1	-1.1	0.7	0.3	2.9	1.1	0.7	-0.1	1.0	-0.8	1.2	1.4	1.7	1.1	0.3	1.2	2.5
Commuting to job workplace: Walk	0.5	0.5	2.1	0.6	-1.1	0.4	-0.7	0.1	-0.8	0.0	-0.9	-0.5	-0.1	0.6	1.4	-0.0	0.0	-0.0	0.5	-1.5	0.1	1.1
Asthma (self-reported)	0.5	1.0	5.0	-0.6	-0.2	0.6	-1.5	0.3	-1.6	-0.7	-0.9	-1.8	-1.0	0.2	0.8	0.8	-0.5	-1.1	0.3	-2.2	0.0	0.9
Arm fat mass (left)	0.5	2.2	9.5	1.0	2.3	1.7	-1.3	0.7	0.1	2.5	1.7	0.0	-0.4	0.7	-1.1	2.0	1.5	1.8	0.8	0.2	0.8	3.1
Number of self-reported non-cancer illnesses	0.5	0.8	2.2	0.6	0.2	1.1	0.7	1.5	-1.5	0.4	-0.7	0.5	0.5	1.1	1.2	0.1	0.8	0.2	1.1	-1.4	1.0	0.8
Medication: Atorvastatin	0.5	0.6	2.8	-0.5	0.1	-0.9	-1.0	-0.6	1.0	0.1	-0.2	0.2	-1.3	-0.7	-1.7	-0.1	-0.5	-0.3	-0.9	0.6	-0.8	0.3
Unable to work because of sickness or disability	0.5	0.6	2.8	-1.1	-0.2	0.0	0.1	-0.9	1.1	0.1	0.0	0.3	-0.1	-0.5	-1.7	-1.6	-0.8	-0.6	-0.0	1.2	-0.1	-0.6
Depression (Nagel 2018)	0.4	0.7	2.0	1.0	1.3	0.9	0.3	0.6	0.7	1.4	0.5	-0.7	-0.1	0.9	-0.0	0.9	0.7	0.8	0.3	0.0	0.5	1.4
Chronotype (morning person)	0.4	0.8	3.0	1.4	0.9	0.0	0.6	0.0	-0.0	0.9	1.2	0.3	0.1	0.5	0.4	1.3	1.7	1.7	-0.2	0.3	0.1	1.6
Number of treatments/medications taken	0.4	0.7	3.4	-0.5	-0.6	0.4	-0.2	0.3	-1.7	-0.7	-1.3	-0.7	-0.9	0.2	0.4	-0.7	-0.5	-1.5	0.1	-1.8	0.3	-0.3
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.9	0.8	0.4	1.1	0.1	0.7	0.4	1.4	0.8	0.2	0.4	0.8	-0.1	1.0	0.9	0.5	0.6	0.1	0.9	0.9
Ever used hormone-replacement therapy (HRT)	0.4	0.5	2.3	0.4	-0.0	0.2	-0.7	0.3	-0.6	0.5	-1.5	-1.1	-1.4	0.2	0.5	0.5	0.7	0.3	-0.3	-1.4	-0.0	0.7
Serious illness, injury or assault to yourself	0.4	0.4	3.9	-0.2	0.1	0.3	-0.2	-0.2	0.4	-0.2	-2.0	-1.2	-0.7	-0.3	-0.2	-1.0	0.0	-0.5	-0.4	-0.4	-0.3	0.2
Alcohol usually taken with meals	0.4	0.7	2.5	0.9	1.1	0.5	-0.4	0.2	-1.0	0.1	1.0	-0.2	-0.0	0.7	-0.4	1.6	0.8	0.8	-0.1	-1.2	0.2	1.3
Happiness	0.4	0.5	1.6	0.1	0.2	1.0	-0.1	0.7	-0.6	1.2	-0.4	-0.4	0.3	1.3	0.7	0.4	0.3	0.4	0.4	-1.1	1.0	1.2
Exposure to tobacco smoke at home	0.4	0.5	2.6	0.5	0.4	-0.1	-0.1	-0.5	-1.1	-0.0	0.1	-1.2	-0.5	0.0	1.0	1.3	-0.0	-0.1	-0.1	-1.6	-0.3	0.8
Loud music exposure frequency	0.4	0.5	2.0	0.4	0.3	0.2	0.7	0.3	0.8	0.8	1.4	1.3	0.5	0.2	0.1	-0.4	0.8	0.7	0.1	1.3	0.1	0.5
Blood clot in the leg (DVT)	0.4	0.6	2.4	0.6	0.8	0.9	-0.1	0.7	-0.1	1.6	-1.1	0.0	0.6	0.5	1.0	-0.1	1.0	0.6	0.8	-0.6	0.7	0.6
Birth weight	0.4	0.9	1.7	0.9	0.4	0.5	1.2	0.7	-1.3	0.4	0.9	0.1	1.2	0.9	1.1	1.0	1.1	1.2	0.6	-0.9	0.7	1.1
Comparative body size at age 10	0.4	1.0	4.7	-0.3	1.8	1.3	-0.7	0.5	1.0	1.8	0.2	-0.4	-0.3	0.9	-0.6	0.3	-0.3	0.9	0.7	1.1	0.8	2.2
Number of full brothers	0.4	0.6	2.8	-0.6	-0.4	-0.1	-0.5	-0.3	1.7	0.8	-0.7	-0.5	-0.3	-0.6	-0.7	-1.1	-0.4	-0.2	-0.3	1.5	-0.5	-0.8
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.4	-1.1	-0.5	-0.7	-0.0	0.1	-0.2	-1.0	0.4	-1.1	-0.2	-0.6	0.5	0.5	-1.2	-0.9	-0.4	-0.2	-0.6	-1.2
Friendships satisfaction	0.4	0.5	3.0	0.1	-0.1	0.4	-0.9	-0.9	-1.0	0.0	-1.3	-0.3	-0.2	0.5	-0.3	-0.6	-0.2	-0.6	-0.2	-1.7	0.3	0.6
Wears glasses or contact lenses	0.4	0.5	2.5	0.0	-1.6	0.7	-0.1	0.1	0.1	0.5	1.1	1.0	0.1	0.6	-1.4	-0.4	0.2	0.4	0.4	0.2	0.8	-0.2
Medication: Blood pressure	0.4	0.7	2.8	0.0	0.9	-0.3	1.5	1.0	0.3	0.1	1.1	1.3	1.1	0.6	0.8	-1.7	-0.1	0.2	0.6	0.9	0.3	-0.0
Age started oral contraceptive pill	0.4	0.5	1.7	0.2	0.1	0.5	-1.2	0.3	-1.0	0.2	-1.3	-0.9	-0.4	0.2	1.0	0.5	0.6	0.4	0.3	-1.3	0.2	0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.9	0.8	0.8	0.7	0.1	0.6	-0.4	1.4	-1.0	0.2	0.8	0.6	0.9	-0.2	1.0	0.5	0.7	-0.7	0.7	0.6
Heart disease (siblings)	0.4	0.5	1.8	-0.9	0.6	-0.3	-0.9	0.1	-0.4	-0.6	-0.4	-1.3	-1.0	-0.5	0.1	0.8	-1.2	-1.1	-0.2	-0.9	-0.7	0.3
Bipolar Disorder or Schizophrenia	0.3	0.8	2.7	0.3	1.3	0.7	0.1	1.2	-1.2	0.8	0.9	0.4	0.5	0.5	0.4	1.6	0.5	0.4	0.8	-1.0	0.9	1.3
Alzheimer’s Disease (including proxy)	0.3	0.5	1.6	0.2	-0.8	0.6	0.8	0.9	-0.0	0.9	-0.8	-0.8	-0.0	0.3	1.3	1.2	0.4	-0.4	0.6	-0.3	0.5	-0.3
BMI	0.3	2.0	9.4	-0.2	3.1	1.3	-1.7	0.4	0.8	2.4	1.6	0.4	-0.9	0.1	-1.8	1.0	0.4	0.8	0.6	1.4	0.7	2.5
Cardiovascular Disease	0.3	0.9	3.9	-0.1	0.3	-0.4	1.9	1.8	-0.2	-0.0	-0.8	1.1	1.0	0.3	1.5	-2.0	-0.3	-0.1	0.4	0.4	0.2	-0.7
Hand grip strength (left)	0.3	0.7	1.9	-0.2	0.3	-1.3	0.4	-1.1	1.4	-0.3	-0.1	0.5	-0.3	-1.0	-0.7	0.5	-0.2	0.4	-1.3	1.4	-1.3	-0.6
Relative age of first facial hair	0.3	0.6	1.7	0.5	0.7	-0.2	1.3	0.2	0.9	-0.1	0.4	0.9	0.9	0.1	1.2	-0.7	0.8	0.9	0.1	1.2	-0.2	-1.3
Angina	0.3	0.3	1.9	-0.5	0.8	0.1	-1.4	0.4	-0.6	0.0	-0.0	0.0	-1.1	-0.1	-0.8	-0.3	-0.3	-0.8	0.1	-0.2	0.3	0.5
Leg fat-free mass (left)	0.3	1.7	8.4	0.4	1.9	0.4	-0.3	0.2	0.7	1.1	2.9	0.1	0.6	-0.0	-1.0	2.1	1.2	1.6	0.3	1.5	-0.1	2.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.3	0.5	0.4	-0.2	-0.7	-1.0	-0.4	-0.0	-0.2	0.5	-0.8	-0.3	-1.2	0.3	0.5	0.4	-0.6	-0.7	-0.3	0.5
Sitting height	0.3	1.8	5.9	1.2	0.7	0.9	1.8	0.8	-1.1	0.6	1.6	0.2	1.9	0.6	0.5	2.4	1.8	1.8	0.9	-0.6	0.7	2.2
Chronic bronchitis/emphysema (father)	0.3	0.3	0.9	0.4	0.4	0.9	0.2	0.1	-0.4	0.6	-0.7	0.6	0.9	0.6	0.9	-0.3	0.4	0.1	0.7	-0.7	0.7	-0.1
Body mass index (BMI)	0.3	1.3	3.5	-0.5	1.8	0.8	-1.8	0.1	0.9	1.8	1.2	-0.6	-1.3	-0.2	-1.8	0.9	0.0	0.5	0.0	1.1	0.1	1.9
Leg predicted mass (left)	0.3	1.8	8.8	0.4	2.0	0.5	-0.2	0.3	0.6	1.2	3.0	0.1	0.7	0.0	-0.9	2.2	1.2	1.7	0.4	1.4	-0.1	2.5
Qualifications: None of the above	0.3	0.5	1.8	-0.8	-0.2	-0.6	-1.3	-0.5	0.8	-0.1	-0.3	0.0	-1.3	-1.1	-0.8	-0.9	-0.1	-0.5	-0.9	0.7	-0.7	0.4
Trunk fat-free mass	0.3	1.6	8.1	-0.1	1.3	-0.2	-0.6	-0.4	0.7	0.3	2.8	-0.8	-0.0	-0.5	-1.5	2.3	0.9	1.4	-0.3	1.3	-0.7	2.3
Number of live births	0.3	0.4	2.9	-0.2	-0.9	0.1	-1.7	-0.5	-0.4	0.0	-0.5	-0.6	-0.8	-0.5	-0.7	0.1	-0.2	-0.8	-0.0	-1.0	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	5.1	0.8	0.8	-1.0	1.2	-0.4	0.7	-0.6	0.6	2.3	1.8	-0.2	-0.3	-0.4	0.8	0.5	-0.5	1.9	-0.4	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.8	-0.4	-0.4	-0.3	0.1	-0.9	1.1	0.6	0.7	0.2	0.3	-0.2	-1.0	-0.3	-0.4	-0.3	-0.3	1.4	-0.2	-0.9
Medication: Cholesterol lowering	0.3	0.5	1.1	0.4	0.3	0.8	1.0	1.0	-0.1	1.0	0.7	0.6	0.5	0.8	0.3	-0.4	0.3	0.5	1.0	0.3	0.8	0.8
Lung cancer (father)	0.3	0.4	1.1	-0.3	-1.0	-0.3	-0.2	-0.9	-0.1	-0.8	0.4	1.0	0.2	-0.6	-0.9	-0.3	-0.1	-0.3	-0.6	-0.2	0.0	-1.1
Trunk predicted mass	0.3	1.6	8.6	-0.0	1.4	-0.1	-0.6	-0.3	0.7	0.4	2.9	-0.7	0.0	-0.4	-1.4	2.4	1.0	1.4	-0.2	1.3	-0.6	2.3
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.6	0.3	-1.2	0.3	0.6	-0.4	-0.3	0.5	0.5	1.3	0.7	-0.2	-0.2	0.9	0.3	-0.1	0.2	0.0	0.4	0.0
Arm fat-free mass (right)	0.3	1.4	6.4	-0.1	1.7	0.0	-0.9	0.0	0.4	0.6	2.4	-1.0	-0.4	-0.3	-1.3	2.0	1.0	1.3	-0.2	1.1	-0.5	2.5
Angina (self-reported)	0.3	0.4	2.1	-0.6	0.5	-0.1	-1.5	0.1	-0.4	-0.3	-0.4	-0.3	-1.2	-0.4	-0.8	-0.6	-0.3	-1.0	-0.1	-0.2	0.0	0.3
Migraine (self-reported)	0.3	0.3	1.2	-0.3	-1.0	0.0	1.1	0.1	-0.9	-0.8	-0.2	0.1	0.3	-0.2	-0.0	0.2	-0.0	-0.6	0.3	-0.9	0.2	-1.1
Arm predicted mass (right)	0.3	1.6	7.5	0.1	1.8	0.2	-0.8	0.3	-0.1	0.6	2.6	-0.8	-0.3	-0.0	-1.1	2.3	1.1	1.3	0.1	0.8	-0.2	2.7
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.8	0.0	0.7	0.9	-0.2	0.2	-1.0	0.2	-0.2	-1.3	-0.5	0.4	0.4	0.8	-0.3	-0.4	0.5	-1.1	0.5	0.3
Whole body fat-free mass	0.3	1.6	8.6	-0.1	1.7	-0.0	-0.5	-0.1	0.7	0.6	2.9	-0.6	0.1	-0.4	-1.3	2.3	0.9	1.4	-0.1	1.5	-0.5	2.3
Mood swings	0.3	0.5	1.0	0.3	0.9	1.0	1.0	0.6	-0.8	0.9	-0.3	-0.7	0.7	0.8	0.9	-0.2	0.4	-0.6	0.8	-0.3	0.9	0.6
Loneliness, isolation	0.3	0.4	2.7	0.1	0.2	0.7	-1.0	0.3	0.2	0.8	-0.3	-1.1	-0.1	0.6	0.2	0.1	0.6	0.8	0.2	-0.3	0.3	1.7
Medication for cholesterol	0.3	0.5	4.2	0.6	1.0	0.8	-0.1	-0.1	-0.2	0.6	1.1	0.2	0.6	0.3	-0.2	2.0	0.5	0.8	0.6	0.0	0.6	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.9	0.0	-0.2	0.7	-0.9	0.8	-0.2	0.9	-1.0	-0.9	-0.2	0.1	0.8	-0.4	-0.1	0.1	0.7	-0.9	0.6	0.7
Mineral and other dietary supplements	0.3	0.4	1.4	0.8	1.0	-0.1	0.6	0.3	-0.4	0.6	0.9	1.2	1.1	0.7	0.5	0.6	0.2	0.6	0.3	-0.1	0.3	0.4
Whole body water mass	0.3	1.7	8.9	0.0	1.8	0.1	-0.5	0.0	0.7	0.7	3.0	-0.5	0.1	-0.3	-1.3	2.3	1.1	1.5	-0.0	1.4	-0.4	2.4
Mother’s age at death	0.3	0.3	1.0	0.5	0.5	0.4	0.3	1.0	-0.2	0.3	0.4	0.7	0.7	0.8	0.5	0.2	0.6	0.9	0.7	-0.2	0.5	0.4
Pain type(s) experienced in last month: Hip pain	0.3	0.3	2.5	-0.2	0.2	0.4	-1.6	0.4	1.0	0.7	0.3	0.4	-0.4	0.4	0.2	-0.1	-0.2	0.3	0.6	0.5	0.4	0.1
Medication: Paracetamol	0.3	0.5	1.5	-0.1	0.4	1.2	0.3	0.1	-1.0	0.9	-1.0	0.2	0.2	0.2	1.0	0.7	0.1	-0.6	0.9	-0.8	1.0	0.2
Alcohol drinker status: Never	0.3	0.4	1.2	0.3	0.3	0.0	1.1	0.8	-0.8	-0.1	0.4	-1.0	0.6	0.7	0.8	0.6	-0.0	-0.4	0.6	-0.9	0.3	0.3
Basal metabolic rate	0.3	1.7	7.9	0.2	1.9	0.3	-0.7	0.0	0.4	0.9	2.8	-0.6	-0.0	-0.2	-1.3	2.4	1.1	1.5	0.0	1.1	-0.3	2.6
Arm fat-free mass (left)	0.3	1.6	7.5	-0.0	1.7	0.2	-0.9	0.1	0.1	0.7	2.6	-1.0	-0.5	-0.1	-1.4	2.4	0.9	1.2	-0.0	0.6	-0.3	2.7
Arm predicted mass (left)	0.3	1.5	6.7	-0.0	1.4	0.1	-0.9	0.0	0.1	0.6	2.6	-1.0	-0.4	-0.3	-1.6	2.3	1.0	1.2	-0.1	0.8	-0.4	2.6
Bipolar Disorder (2018)	0.2	0.3	1.2	-0.5	0.2	-0.1	-0.6	-0.4	-0.5	-0.3	-0.1	-0.4	-0.7	-0.4	-0.9	0.8	-0.2	-0.0	-0.3	-0.8	-0.3	1.1
Depressed Affect (Nagel 2018)	0.2	0.3	1.4	0.1	1.2	0.6	-0.0	0.2	-0.3	0.8	-0.7	-0.9	0.1	0.5	0.3	-0.6	0.4	0.0	0.2	-0.3	0.4	1.1
Schizophrenia vs Biploar Disorder	0.2	0.3	1.3	0.2	-0.0	0.1	0.6	0.5	-0.5	0.0	1.2	1.1	0.5	0.4	0.8	0.0	0.2	-0.2	0.2	-0.2	0.4	0.5
Age at First Birth	0.2	0.2	1.5	0.4	0.2	0.3	-0.2	0.0	0.5	0.4	0.1	1.2	0.6	0.2	0.4	0.2	0.4	1.1	0.3	0.2	-0.0	0.0
HDL Cholesterol	0.2	0.3	1.7	0.3	0.2	0.4	-0.7	-0.5	-0.2	-0.1	-0.6	-0.5	-1.3	0.2	-0.3	0.9	0.1	0.3	-0.2	-1.0	-0.2	-0.0
Primary Biliary Cirrhosis	0.2	0.3	1.9	-1.4	0.1	-0.0	-0.1	-0.1	0.8	0.3	-0.3	-0.8	-0.2	-0.2	-0.4	-0.8	-1.0	-0.1	-0.2	1.1	-0.1	-0.0
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.7	0.3	0.2	0.6	0.7	0.7	-0.1	0.6	0.7	-0.1	0.4	0.8	0.2	-0.2	0.4	0.5	0.5	0.4	0.7	0.7
Smoking Status	0.2	0.4	1.6	-0.2	-0.0	-0.4	1.1	-1.0	0.6	-0.4	0.6	0.9	-0.0	-0.7	-1.3	0.1	-0.1	-0.1	-0.2	0.8	-0.2	-1.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	1.0	0.6	0.1	1.0	-1.0	0.5	0.2	0.3	-0.3	-0.1	0.1	0.5	0.2	0.7	0.1	-0.0	0.3	-0.5	0.3	0.2
Severe depression (siblings)	0.2	0.2	0.8	-0.8	-0.9	0.1	0.0	-0.4	0.3	0.1	-0.1	-0.7	-0.8	0.1	-0.1	-0.3	-0.7	-0.9	-0.2	0.1	-0.2	0.2
Current tobacco smoking	0.2	0.4	2.2	-0.6	-0.4	-0.7	1.5	-0.7	0.6	-0.1	-0.4	0.1	0.3	-0.6	-0.5	-0.5	-0.5	-0.3	-0.2	0.9	-0.4	-0.2
Past tobacco smoking	0.2	0.4	1.8	-0.3	0.5	0.4	1.0	1.0	-0.0	1.0	-0.2	-1.3	0.3	0.6	0.9	0.4	-0.6	-0.4	0.1	0.1	0.2	0.8
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.9	-0.2	-0.1	0.7	1.4	0.5	-0.6	0.4	-0.1	-1.2	-0.3	0.2	0.1	0.2	0.2	-0.2	0.4	-0.2	0.4	0.7
Financial difficulties in last 2 years	0.2	0.3	0.9	-0.9	0.6	-0.0	-0.5	-0.8	0.7	0.4	-0.2	-0.3	-0.8	-0.3	-0.4	-0.8	-0.8	-0.4	-0.2	0.7	-0.2	0.3
Mouth/teeth dental problems	0.2	0.3	1.4	-0.3	0.6	0.1	0.4	0.2	0.7	0.2	1.1	0.5	1.0	0.1	0.4	0.3	0.4	0.9	0.0	1.2	0.2	0.2
Length of working week for main job	0.2	0.2	0.8	-0.1	0.5	-0.6	-0.3	-0.3	-0.3	0.1	0.1	-0.6	-0.7	-0.4	0.2	0.8	-0.1	-0.2	-0.9	-0.3	-0.5	0.2
Breastfed as a baby	0.2	0.3	1.7	0.1	1.2	-0.3	-0.8	-0.0	-0.1	-0.1	-0.7	1.3	0.1	0.1	0.6	0.2	0.4	-0.4	0.1	0.4	0.1	0.6
Medication: Paracetamol	0.2	0.3	1.3	-0.7	-0.8	0.4	-0.0	-0.9	-0.1	0.0	-1.2	0.2	-0.3	-0.6	0.0	-0.3	-0.5	-1.1	0.0	0.1	0.2	-0.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.4	-0.2	0.1	-0.2	-1.1	-0.9	-0.2	-0.5	-0.2	-0.9	-0.5	-0.4	-0.2	1.2	-0.2	-0.1	-0.5	-0.7	-0.5	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.8	0.4	0.8	-0.0	-0.8	-0.4	0.8	0.9	-0.4	0.5	-0.1	0.1	0.8	0.7	0.4	0.4	-0.1	0.8	-0.0	-0.2
Medication: Ibuprofen	0.2	0.3	1.3	0.0	0.2	0.5	0.5	-0.4	0.4	1.1	0.7	0.3	0.5	0.4	-0.7	0.0	-0.3	-0.3	0.3	0.8	0.5	-0.3
Medication: Seretide 50 evohaler	0.2	0.2	1.6	-0.2	-0.7	0.2	0.6	0.2	0.2	0.3	-0.1	-0.5	0.2	-0.1	-0.1	1.3	-0.3	0.0	0.2	-0.3	-0.1	-0.3
Alcohol intake frequency.	0.2	0.5	2.0	-0.4	1.4	-0.2	0.9	0.4	-1.4	-0.5	-0.4	-0.8	-0.4	0.4	0.5	0.1	-0.3	-1.2	0.3	-1.2	0.2	0.5
Comparative height size at age 10	0.2	1.1	5.0	0.7	0.7	-0.2	-0.4	-0.6	-0.8	-0.9	1.8	-1.2	0.1	0.2	-0.5	2.2	0.9	1.1	-0.4	-0.8	-0.6	2.2
Family relationship satisfaction	0.2	0.2	1.2	0.1	1.1	0.0	-0.2	-0.5	0.4	0.9	0.3	0.1	-0.0	0.3	0.3	0.0	0.1	0.5	-0.2	-0.2	-0.0	0.7
Leg fat-free mass (right)	0.2	1.3	6.7	-0.2	1.9	-0.0	-0.3	-0.2	0.9	0.7	2.6	-0.1	0.3	-0.5	-1.1	1.7	0.7	1.2	-0.1	1.9	-0.5	1.8
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.7	-0.4	0.1	0.1	1.3	0.4	-0.0	-0.1	0.6	0.8	0.9	-0.4	0.2	0.2	-0.1	-0.1	0.4	0.3	0.3	-0.8
Smoking status: Current	0.2	0.3	4.1	-0.1	-0.0	-0.4	2.0	-0.3	0.5	0.3	0.1	0.4	0.7	-0.2	-0.1	0.0	0.1	0.3	0.2	1.0	-0.1	0.2
Leg predicted mass (right)	0.2	1.3	6.4	-0.2	1.8	0.0	-0.3	-0.2	0.8	0.7	2.5	-0.2	0.3	-0.5	-1.1	1.7	0.7	1.2	-0.0	1.8	-0.5	1.9
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.7	-0.8	-0.6	-0.0	-0.0	-0.2	-0.3	-0.5	-0.0	-0.7	-0.8	-0.8	-0.4	0.1	-0.1	-0.6	0.0	-0.1	-0.1	-0.1
Ever smoked	0.2	0.3	2.5	0.6	-0.5	-0.0	-0.4	-0.2	-0.8	-0.5	0.6	1.6	0.2	0.1	-0.2	0.3	0.6	0.5	0.5	-0.5	0.4	-0.0
Pain experienced in last month	0.2	0.3	1.9	0.4	-1.1	-0.1	-1.4	-0.3	0.3	0.0	-0.2	-0.8	-0.0	0.2	0.6	0.4	0.1	0.8	-0.2	-0.4	-0.2	0.7
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	0.1	-0.6	0.3	0.2	-0.6	-0.5	0.1	-0.7	-0.8	-0.3	0.3	-0.5	-0.3	0.0	-0.3	0.1	-0.5	0.2	0.5
Coronary Artery Disease (CAD)	0.1	0.1	0.9	0.1	1.0	-0.6	-0.0	-0.0	0.2	0.0	-0.4	0.1	0.2	-0.4	-0.1	-0.7	0.1	0.2	-0.5	0.3	-0.3	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.6	-0.2	0.0	-0.0	0.2	-0.5	0.8	0.3	-0.8	-0.2	0.0	-0.4	-0.6	-0.5	0.1	-0.0	-0.3	0.2	-0.3	0.3
Supplements: Glucosamine	0.1	0.2	1.0	0.3	0.3	0.4	-0.1	-0.3	-0.2	0.2	-0.1	0.1	-0.4	-0.1	-1.0	0.6	0.7	0.1	-0.4	-0.4	-0.1	0.8
Forced vital capacity (FVC)	0.1	0.5	2.1	0.0	-0.8	-1.3	0.3	-0.7	0.2	-1.4	-0.3	0.6	0.7	-0.8	0.1	-0.3	0.2	-0.6	-0.8	1.0	-0.9	-0.6
Medication: Simvastatin	0.1	0.2	1.4	-0.5	-0.4	0.0	0.3	0.0	-0.0	-0.0	0.0	-0.0	-0.3	0.0	-1.2	-1.0	-0.7	-0.6	0.0	0.1	0.0	0.2
Noisy workplace	0.1	0.2	1.5	-0.5	1.2	-0.5	-0.4	-0.2	-0.4	-0.4	0.4	-0.5	0.1	-0.3	0.2	-0.2	-0.5	-0.1	-0.0	-0.3	-0.3	0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.6	0.6	0.4	0.1	0.5	0.1	-0.5	-0.1	-0.6	0.7	0.6	0.4	0.5	0.6	0.6	0.4	-0.1	-0.6	-0.1	0.7
Prospective memory result	0.1	0.1	0.7	0.2	0.8	-0.6	0.8	0.2	0.1	-0.3	0.2	-0.3	0.2	-0.2	-0.0	0.2	-0.1	-0.3	-0.1	0.5	-0.2	-0.5
Pulse wave Arterial Stiffness index	0.1	0.1	0.5	-0.3	-0.3	0.0	0.3	0.4	-0.0	-0.7	0.1	-0.5	-0.3	0.1	0.1	-0.6	-0.3	-0.2	0.2	-0.3	-0.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.9	0.3	0.1	-0.2	0.9	-0.2	-0.5	-0.9	-0.5	0.6	0.6	0.3	0.2	-0.8	-0.2	-0.3	0.1	-0.4	-0.1	-0.3
Pulse wave peak to peak time	0.1	0.1	0.9	0.4	0.3	0.0	-0.0	-0.2	-0.2	0.7	0.2	0.5	0.3	-0.1	0.1	1.0	0.5	0.3	-0.1	0.2	0.1	0.3
Medication for pain relief, constipation, heartburn	0.1	0.1	0.6	0.2	-0.2	-0.3	0.1	0.1	0.8	-0.2	-0.5	-0.3	0.2	0.3	0.8	-0.1	-0.1	0.4	-0.2	0.2	-0.5	-0.2
Neck or shoulder pain in last month	0.1	0.2	0.9	-0.5	1.0	-0.4	-0.6	-0.2	-0.3	-0.6	0.2	0.6	-0.7	-0.3	0.1	0.0	-0.4	-0.7	-0.1	0.0	-0.2	-0.3
Knee pain experienced in last month	0.1	0.2	1.9	-0.1	0.4	-0.1	0.5	0.0	0.5	-0.0	-0.0	1.4	0.5	-0.3	-0.2	-0.4	0.2	-0.0	-0.3	0.4	-0.3	-0.7
Miserableness	0.1	0.2	0.7	-0.1	0.6	0.5	0.2	0.4	-0.6	0.7	-0.2	-0.8	-0.1	0.3	0.2	0.5	0.2	-0.3	0.1	-0.5	0.3	0.7
Triglycerides	0.0	0.1	0.3	0.1	0.0	-0.3	-0.1	0.1	0.1	-0.1	0.2	0.6	0.3	-0.2	0.0	-0.5	0.0	-0.2	0.1	0.1	-0.0	0.1
Hair Pigment	0.0	0.7	4.3	-0.9	-1.0	-0.4	0.8	0.8	-0.7	-1.4	2.1	-0.4	0.8	-0.1	0.6	0.3	-0.8	-0.7	0.4	-0.4	0.1	-0.9

Hub : Genes

AKIP1

Models

Trait associations