Hub : Genes

SCUBE2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0530 0.0240 9.8e-04 0.005 0.020 0.034 0.022 0.014 6.7e-02 1.4e-03 4.5e-05 8.8e-04 6.3e-03
2 GTEx Adipose Subcutaneous 0.3130 0.0640 2.9e-14 0.273 NA 0.244 NA 0.257 2.2e-22 NA 6.8e-20 NA 5.5e-21
3 GTEx Adipose Visceral Omentum 0.0890 0.0470 6.9e-03 0.145 NA 0.118 NA 0.147 6.1e-08 NA 1.1e-06 NA 4.5e-08
4 GTEx Artery Tibial 0.0962 0.0422 3.7e-03 -0.003 NA 0.009 NA -0.001 7.2e-01 NA 5.8e-02 NA 4.0e-01
5 GTEx Brain Cerebellar Hemisphere 0.3730 0.1110 2.2e-04 0.187 NA 0.184 NA 0.140 1.5e-05 NA 1.9e-05 NA 2.0e-04
6 GTEx Brain Cerebellum 0.2270 0.0880 1.1e-03 -0.009 NA 0.031 NA 0.002 7.9e-01 NA 4.3e-02 NA 2.8e-01
7 GTEx Esophagus Mucosa 0.1270 0.0500 1.6e-03 0.004 NA -0.001 NA 0.003 1.6e-01 NA 4.0e-01 NA 1.8e-01
8 GTEx Esophagus Muscularis 0.1160 0.0430 1.4e-04 0.132 NA 0.115 NA 0.119 2.1e-08 NA 1.9e-07 NA 1.0e-07
9 GTEx Heart Atrial Appendage 0.3920 0.0920 8.7e-08 0.298 NA 0.267 NA 0.289 7.0e-14 NA 2.2e-12 NA 2.0e-13
10 GTEx Heart Left Ventricle 0.1673 0.0537 5.3e-05 0.063 NA 0.116 NA 0.122 2.9e-04 NA 9.9e-07 NA 5.2e-07
11 GTEx Lung 0.1751 0.0733 1.8e-03 0.020 NA 0.051 NA 0.028 1.1e-02 NA 9.2e-05 NA 3.2e-03
12 GTEx Nerve Tibial 0.2297 0.0622 2.0e-06 0.110 NA 0.140 NA 0.135 3.7e-08 NA 4.1e-10 NA 8.0e-10
13 GTEx Pancreas 0.2520 0.0730 1.2e-05 0.245 NA 0.246 NA 0.272 9.5e-11 NA 9.2e-11 NA 6.2e-12
14 GTEx Skin Sun Exposed Lower leg 0.1190 0.0450 1.1e-03 0.006 NA 0.005 NA 0.003 9.7e-02 NA 1.1e-01 NA 1.7e-01
15 GTEx Testis 0.2670 0.0750 4.8e-06 0.273 NA 0.252 NA 0.020 1.6e-12 NA 1.4e-11 NA 4.2e-02
16 GTEx Thyroid 0.1670 0.0600 7.6e-05 0.023 NA 0.034 NA 0.044 7.0e-03 NA 1.3e-03 NA 2.4e-04
17 METSIM Adipose 0.2126 0.0463 0.0e+00 0.231 0.179 0.221 0.229 0.226 5.4e-34 5.7e-26 2.2e-32 1.2e-33 3.5e-33
18 TCGA Esophageal Carcinoma 0.1750 0.0920 1.8e-03 0.036 0.087 0.076 NA 0.082 2.6e-02 1.0e-03 2.1e-03 NA 1.4e-03
19 TCGA Kidney Renal Clear Cell Carcinoma 0.0575 0.0246 9.4e-05 0.026 0.029 0.024 NA 0.021 5.5e-04 3.0e-04 9.3e-04 NA 1.9e-03
20 TCGA Brain Lower Grade Glioma 0.0881 0.0326 1.5e-05 0.027 0.043 0.022 NA 0.023 4.2e-04 1.1e-05 1.4e-03 NA 1.1e-03
21 TCGA Prostate Adenocarcinoma 0.1742 0.0893 9.7e-04 0.078 0.050 0.057 NA 0.074 1.6e-08 5.1e-06 1.2e-06 NA 3.6e-08
22 TCGA Rectum Adenocarcinoma 0.1590 0.0830 5.4e-03 0.049 0.064 0.044 NA 0.029 2.7e-02 1.3e-02 3.5e-02 NA 7.0e-02
23 TCGA Thyroid Carcinoma 0.1190 0.0450 7.3e-07 0.068 0.062 0.065 NA 0.068 3.4e-07 1.2e-06 5.8e-07 NA 3.5e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Bipolar Disorder (2018) 0.4 0.6 3.4 0.9 -0.3 -0.1 0.6 -0.0 0.0 -1.8 -0.0 -0.3 -0.5 0.6 0.0 -0.1 -1.1 0.7 0.1 -0.0 -1.2 -1.3 0.9 -0.3 -0.1 1.4
Bipolar Disorder or Schizophrenia 0.2 0.5 4.4 0.1 0.0 0.3 0.8 -0.5 0.0 -2.1 0.4 0.2 0.3 0.5 0.2 -0.2 -2.0 0.2 0.5 0.4 -0.6 -1.0 -0.1 -0.2 -0.7 0.6
Depressed Affect (Nagel 2018) 0.6 1.3 6.0 -1.1 -0.2 0.0 0.7 -2.5 0.0 1.1 0.1 -0.3 0.1 -0.5 -0.2 -2.1 1.2 -2.0 -0.0 -0.1 -0.1 0.2 -2.2 2.1 -0.1 -1.2
Depression (Nagel 2018) 0.4 0.5 2.7 0.4 -0.3 0.0 1.3 0.4 0.0 -1.4 -0.1 -0.4 0.5 -0.0 0.2 0.6 -0.8 1.4 0.1 -0.0 -0.5 0.0 0.4 -1.6 -0.2 1.6
Intelligence (Savage-Jansen 2018) 1.1 3.3 9.4 -0.4 -2.6 -2.3 -1.3 -1.3 0.0 -0.4 -2.3 -2.1 -1.7 -0.8 -1.0 1.3 -2.5 1.1 -2.5 -2.1 -2.5 -3.1 0.6 -0.8 -2.3 2.0
Neuroticism (Nagel 2018) 1.6 3.8 11.3 -2.5 -2.5 -2.1 -2.2 -3.1 0.0 1.2 -2.0 -2.0 -0.8 -1.8 -1.1 -0.9 -0.6 -1.6 -1.9 -2.2 -2.0 -1.2 -3.4 1.3 -3.3 -0.9
Schizophrenia (2018) 0.2 0.4 2.7 -0.7 0.2 0.4 0.4 -0.6 0.0 -1.2 0.5 0.5 0.7 0.2 0.3 -0.2 -1.6 -0.3 0.6 0.5 0.3 -0.3 -0.9 0.0 -0.9 -0.3
Schizophrenia vs Biploar Disorder 1.7 2.2 8.9 -2.1 -0.1 -0.3 -0.8 -0.4 0.0 1.6 -0.2 -0.3 -0.2 -0.6 -0.9 -2.2 1.7 -3.0 0.0 -0.2 1.2 0.4 -2.8 2.7 0.4 -2.8
Worry (Nagel 2018) 2.8 5.8 15.3 -2.3 -3.6 -3.4 -2.9 -2.3 0.0 0.5 -3.4 -3.0 -1.8 -1.9 -2.1 0.9 -1.6 -0.6 -3.1 -3.5 -2.5 -2.2 -2.4 0.7 -3.9 -0.2
Alzheimer’s Disease (in mother) 1.0 1.2 4.2 -0.3 -1.6 -1.5 -2.0 0.3 0.0 0.9 -1.5 -1.1 -1.5 0.3 -1.5 0.3 -0.7 0.4 -1.5 -1.6 -0.9 -1.2 0.1 -0.3 -1.1 0.6
Alzheimer’s Disease (in father) 0.2 0.3 0.8 0.1 0.3 0.6 0.2 -0.9 0.0 -0.3 0.6 0.5 0.7 -0.6 0.2 0.9 -0.4 0.6 0.4 0.6 0.0 -0.2 0.7 -0.6 -0.4 -0.1
Alzheimer’s Disease (including proxy) 0.1 0.2 1.3 -0.2 -0.5 -0.3 -1.0 -0.1 0.0 0.1 -0.2 -0.1 0.1 -0.0 -0.6 1.1 -0.6 0.6 -0.3 -0.3 0.0 -0.2 0.1 -0.7 -0.4 -0.0
Crohns Disease (2017) 0.4 0.9 4.9 -1.0 -0.1 0.0 -0.1 -1.1 0.0 2.2 0.1 0.1 0.4 -0.5 1.3 0.6 0.9 -0.6 0.2 0.1 -2.1 0.5 -1.0 1.0 -1.7 -0.1
Irritable Bowel Disease (IBD) 0.7 1.7 9.5 -1.3 -0.2 -0.2 -0.8 -1.3 0.0 3.1 -0.1 -0.0 0.3 -1.3 1.5 -0.6 1.8 -1.2 0.6 0.0 -2.1 0.9 -2.1 1.4 -2.1 -0.8
Ulcerative Colitis (UC) 0.7 1.4 8.4 -0.7 -0.3 -0.4 -1.0 -1.0 0.0 2.9 -0.3 -0.1 -0.2 -1.3 1.0 -1.4 1.9 -1.1 0.5 -0.2 -1.3 0.6 -1.8 1.3 -1.5 -0.9
Major Depression (MDD) 1.8 2.2 5.7 -1.6 -2.2 -2.1 -0.9 -1.4 0.0 0.3 -2.1 -2.4 -1.4 -1.6 -1.8 -0.3 -0.5 -0.7 -1.9 -2.2 -1.4 -1.7 -1.3 0.6 -1.2 1.0
Reaction Time 3.1 5.9 18.6 -2.3 -3.3 -3.2 -3.4 1.3 0.0 1.3 -3.3 -2.9 -2.9 -1.5 -4.3 -1.2 -2.5 -0.6 -3.4 -3.3 0.2 -3.1 -1.1 0.8 -2.0 -0.0
Verbal and Numeric Reasoning (VNR) 1.2 2.8 8.4 -0.8 -2.2 -1.8 -0.4 -2.0 0.0 1.3 -1.8 -1.7 -1.4 -1.4 -0.3 1.5 -1.6 0.9 -2.4 -1.7 -2.9 -2.1 -0.1 -0.7 -2.9 1.7
Breast Cancer 0.2 0.4 2.8 -1.0 0.1 0.3 -0.4 -0.3 0.0 -0.6 0.3 0.3 0.7 -1.4 -0.2 -0.3 -0.4 -0.5 -0.3 0.3 0.1 0.2 -1.7 0.2 -0.9 -1.0
Ovarian Cancer 1.4 1.9 4.0 0.4 2.0 1.9 1.9 -1.3 0.0 -0.8 1.9 1.8 1.0 1.3 1.7 -0.5 1.3 -0.5 1.6 1.9 1.2 1.4 0.2 1.2 1.6 -0.7
Prostate Cancer 1.7 2.4 9.1 -2.0 0.5 0.4 -1.1 -1.9 0.0 1.3 0.5 0.3 -0.2 -0.8 -0.5 -0.9 1.4 -3.0 0.4 0.3 1.9 0.6 -3.0 2.7 0.9 -3.0
Age at First Birth 0.2 0.3 1.7 -1.0 0.1 0.2 -0.5 0.5 0.0 -1.3 0.1 0.4 0.7 -0.5 -0.2 0.4 -1.3 -0.3 -0.1 0.2 -0.1 0.1 -1.1 -0.4 -0.1 -0.2
Bipolar Disorder (2011) 1.2 1.2 5.1 -0.6 -1.4 -1.0 0.4 -0.4 0.0 -1.4 -1.1 -1.4 -0.2 -1.1 -0.9 -0.9 -2.2 0.3 -1.0 -1.0 -1.5 -1.3 0.3 0.0 -1.3 1.8
Body Mass Index (BMI) (2010) 0.6 0.8 4.8 0.5 -0.2 -0.2 2.2 -0.1 0.0 -1.2 -0.3 -1.0 -0.1 -0.9 -0.2 1.7 -0.1 1.0 -0.2 -0.2 0.3 0.2 1.1 -1.8 0.2 1.1
Coronary Artery Disease (CAD) 1.0 1.2 4.0 -0.3 1.1 1.0 0.3 0.1 0.0 -0.3 1.0 1.1 1.1 1.5 0.7 -1.3 0.2 -0.7 1.9 1.0 2.0 1.6 0.6 1.6 1.4 -1.1
Crohns Disease (2012) 0.7 1.1 2.8 -1.4 0.3 0.6 1.3 -1.6 0.0 1.1 0.7 0.6 1.0 -1.4 1.3 -0.1 -0.5 -1.2 0.3 0.7 -1.7 0.1 -1.6 1.3 -1.6 -0.9
Mean Putamen Volume 1.4 1.6 4.5 0.9 1.6 1.3 1.1 0.9 0.0 0.3 1.4 1.5 1.5 -0.1 1.3 -2.1 0.9 -0.6 1.7 1.4 1.0 1.5 0.7 1.1 2.1 -0.5
Fasting Glucose 0.2 0.2 1.7 0.2 0.5 0.2 0.1 -0.4 0.0 -0.3 0.1 0.1 0.2 0.6 -0.3 0.0 0.5 -0.6 0.3 0.2 1.1 0.6 -0.1 0.4 1.3 -0.5
HbA1C 0.6 0.6 3.0 1.3 0.2 -0.0 0.2 -0.9 0.0 -0.9 -0.1 -0.1 -0.9 1.0 0.1 1.7 1.0 0.8 0.2 -0.0 0.2 0.0 1.6 -0.2 1.2 0.7
HDL Cholesterol 1.8 2.9 9.6 -1.8 -2.4 -2.3 -3.1 -0.5 0.0 0.3 -2.4 -2.1 -2.0 -0.5 -2.7 -0.8 -2.0 -0.7 -2.2 -2.4 0.8 -1.9 -1.1 0.6 -0.6 -0.6
LDL Cholesterol 1.7 2.6 9.6 2.1 2.0 1.9 2.2 1.5 0.0 -0.3 2.0 1.8 1.1 1.8 1.6 -0.4 0.1 1.0 2.3 2.1 1.2 0.9 3.1 -0.7 2.0 0.5
Lupus 1.6 2.4 5.1 0.3 -2.0 -1.9 -1.8 -1.0 0.0 -1.0 -2.0 -1.6 -1.7 1.5 -1.8 0.8 -1.9 0.8 -2.0 -2.0 -1.3 -2.1 1.3 -0.6 -2.3 0.9
Neuroticism (2016) 1.8 2.7 7.4 0.2 -2.6 -2.5 -1.4 -1.3 0.0 1.5 -2.4 -2.4 -2.0 0.1 -1.2 0.3 -0.3 0.9 -1.9 -2.7 -2.3 -1.1 0.0 -0.5 -2.1 1.4
Primary Biliary Cirrhosis 0.3 0.4 3.2 -0.4 0.5 0.5 0.2 0.8 0.0 -0.1 0.6 0.4 1.0 -1.8 0.4 0.1 -0.8 0.0 1.0 0.6 0.7 0.2 0.5 0.0 0.6 -0.0
Rheumatoid Arthritis 0.4 0.6 2.0 -0.1 -1.0 -1.1 -0.2 0.1 0.0 1.4 -1.0 -1.0 -0.8 -1.2 -0.6 0.6 0.7 -0.6 -0.7 -0.9 -0.4 -0.2 -0.6 0.6 -0.7 -0.5
Schizophrenia (2014) 0.2 0.3 0.9 -0.5 0.2 0.4 0.9 -0.8 0.0 -0.7 0.4 0.4 0.6 0.8 0.4 -0.8 -0.9 -0.5 0.7 0.5 -0.1 -0.2 -0.9 0.3 -0.6 -0.1
Triglycerides 0.5 0.8 2.2 0.8 1.4 1.4 0.8 0.9 0.0 -0.3 1.5 1.3 1.2 0.4 1.2 -0.4 0.7 -0.1 1.4 1.5 0.0 0.8 -0.0 -0.2 0.5 -0.4
Type 2 Diabetes (T2D) (2012) 0.3 0.4 1.3 0.1 0.6 0.7 0.7 0.7 0.0 0.3 0.7 0.6 0.8 -0.5 0.4 -1.0 -0.0 -0.1 0.7 0.7 0.7 0.4 -0.8 -0.6 0.1 -1.1
Ulcerative Colitis 0.4 0.6 2.0 -0.9 0.3 0.3 -0.5 -0.4 0.0 0.6 0.4 0.6 0.8 -0.7 1.3 -1.4 0.5 -0.5 0.8 0.5 -1.0 0.5 -1.1 0.6 -1.4 -0.5
Blood Eosinophil Count 0.2 1.2 4.9 -0.7 -0.3 -0.4 1.6 -0.1 0.0 -0.6 -0.5 -0.9 -0.9 -0.2 -1.9 -1.5 0.3 -1.7 -0.1 -0.3 2.0 0.1 -0.8 1.4 2.2 -0.9
Blood Platelet Count 1.9 21.9 132.2 6.3 4.7 3.3 2.4 6.8 0.0 -1.3 3.5 3.2 0.4 5.2 -0.4 0.9 4.5 3.0 3.5 3.2 9.4 4.7 5.6 -1.5 11.5 0.5
Blood Red Count 0.8 7.5 48.3 3.6 2.1 1.6 4.5 0.6 0.0 -1.6 1.7 1.1 -1.7 2.9 -2.0 0.2 1.3 0.2 0.3 1.8 6.9 0.4 3.0 0.1 7.0 0.3
Blood White Count 0.3 2.5 16.9 1.7 1.1 0.8 -0.2 2.5 0.0 -0.2 0.7 0.7 -0.7 0.1 -0.9 0.9 1.1 1.6 0.8 0.9 4.1 0.8 1.6 -2.0 3.6 -0.3
Heel T-Score 1.5 12.0 56.7 -2.2 2.3 3.7 2.5 1.9 0.0 -4.4 3.4 3.2 7.5 -1.6 3.8 2.6 -6.5 3.4 2.2 3.4 -2.4 2.0 -0.6 -5.0 -2.8 2.7
BMI 0.2 0.9 5.5 -1.5 -0.6 -0.1 2.4 -1.4 0.0 -1.1 -0.2 -1.1 -0.3 -0.5 -1.7 -0.3 -1.4 -0.3 -0.6 -0.3 0.6 -0.7 0.1 -1.1 -0.6 0.1
Height 0.4 7.3 28.4 -0.0 -3.6 -3.2 -0.5 -5.3 0.0 2.4 -3.3 -2.8 -2.8 -0.6 -0.9 -0.6 -0.7 -1.4 -2.9 -3.2 -5.1 -3.4 -0.6 1.8 -4.1 1.4
Waist Hip Ratio (WHR) 2.8 12.8 29.3 -3.5 -5.0 -4.3 -4.8 -1.3 0.0 0.6 -4.4 -4.6 -3.0 -3.7 -4.3 0.3 -4.3 0.8 -4.8 -4.7 -2.6 -4.3 -2.2 -2.6 -5.4 0.9
Systolic Blood Pressure 0.6 3.2 16.1 0.8 1.0 0.9 2.4 4.0 0.0 -1.3 1.0 0.7 2.4 -0.7 2.5 1.6 -0.9 2.8 1.6 1.2 -2.3 1.5 0.9 -2.4 -0.2 1.8
Smoking Status 0.7 1.8 5.7 -1.2 0.2 -0.2 -1.6 0.6 0.0 2.2 -0.1 -0.1 0.3 -0.6 -0.2 -2.0 2.4 -1.8 0.9 -0.2 1.6 2.1 -1.8 1.3 1.0 -2.3
Allergy or Eczema 3.1 8.2 19.5 -0.6 -4.4 -3.9 -1.6 -1.3 0.0 -1.0 -4.0 -3.9 -3.0 -1.2 -3.2 2.4 -2.9 0.6 -4.0 -4.0 -3.4 -3.5 -1.2 -1.3 -4.4 1.7
Cardiovascular Disease 0.2 0.6 2.9 0.7 0.0 -0.3 0.2 0.6 0.0 1.7 -0.2 -0.2 0.5 -0.3 0.7 1.5 1.2 0.1 0.4 -0.3 -1.2 1.4 -1.1 0.8 0.1 -0.6
Hypothyroidism (self reported) 0.1 0.3 1.6 0.3 0.2 0.0 0.1 1.3 0.0 -0.3 0.1 0.1 -0.3 -0.8 -0.1 -1.0 -0.2 -0.2 0.5 0.2 0.7 -0.7 0.4 0.3 0.8 -0.0
Respiratory disease 2.6 5.8 15.2 -2.2 -3.3 -3.1 -2.5 -1.2 0.0 0.5 -3.1 -2.7 -3.9 -0.7 -3.8 0.8 -2.1 -0.8 -3.9 -3.2 -0.2 -3.5 -1.9 0.2 -2.4 -0.7
Type 2 Diabetes (T2D) (2018) 2.7 5.1 14.5 -1.8 -3.4 -3.3 -2.4 -0.8 0.0 0.4 -3.4 -3.6 -3.3 -1.0 -3.8 -0.4 -0.6 -0.5 -3.0 -3.5 -0.2 -2.5 -0.6 -0.5 -2.1 -0.6
Lung FEV1/FVC ratio 3.1 15.8 42.1 2.3 4.9 4.8 6.2 1.4 0.0 -4.1 4.8 4.1 6.5 3.3 6.5 -2.4 0.2 1.6 6.5 5.1 -0.3 3.9 3.1 -0.2 3.4 2.8
Lung FVC 1.3 6.8 17.1 1.9 4.1 4.0 1.1 2.2 0.0 0.6 4.0 4.1 2.8 1.0 3.5 -1.2 3.1 0.0 3.2 4.0 1.6 3.0 -0.1 0.7 2.7 -1.3
Neuroticism 2.4 5.7 12.6 -2.8 -3.4 -3.1 -2.3 -2.9 0.0 1.6 -3.1 -3.0 -2.0 -2.0 -2.3 -0.6 -1.0 -1.2 -3.0 -3.4 -2.4 -1.9 -2.7 1.2 -3.5 -0.2
Chronotype (morning person) 0.2 0.4 1.8 -0.4 0.3 0.4 0.7 -0.9 0.0 1.3 0.3 0.4 0.5 -0.1 0.7 -0.6 0.6 -0.9 0.6 0.5 -0.0 0.6 -0.9 0.9 0.2 -0.0
Hair Pigment 0.1 2.2 7.1 1.7 -2.2 -2.7 -0.8 -0.4 0.0 1.0 -2.4 -2.4 -2.1 -1.3 -1.2 1.1 0.2 0.1 -1.6 -2.4 -1.6 -1.0 0.4 -0.1 -0.8 0.8
Tanning 0.3 3.5 14.1 0.7 2.2 1.8 1.5 2.1 0.0 0.9 1.8 1.8 1.2 0.1 0.8 0.8 3.0 0.3 1.8 2.0 3.5 2.7 0.7 -0.1 3.8 -1.9
Hand grip strength (left) 1.2 3.1 9.2 2.6 1.8 1.7 2.6 1.4 0.0 0.2 1.6 2.0 1.6 3.0 2.3 1.0 1.4 1.3 1.7 1.8 -0.1 1.8 2.7 -0.4 1.5 1.2
Number of treatments/medications taken 1.2 2.1 7.4 -2.0 -1.2 -1.3 -2.5 -0.9 0.0 1.5 -1.2 -1.1 -1.5 -0.4 -1.5 0.2 0.4 -2.3 -1.0 -1.3 1.0 -0.0 -2.1 1.8 -0.5 -2.7
Average weekly spirits intake 0.3 0.4 2.1 -0.1 0.1 0.1 0.9 1.4 0.0 -0.5 0.2 0.0 0.3 -1.2 0.3 -0.4 -0.9 1.0 0.3 0.2 0.2 -0.0 -0.5 -1.4 -0.3 0.5
Sensitivity / hurt feelings 1.3 2.2 4.3 -1.9 -1.9 -1.7 -1.9 -1.5 0.0 1.9 -1.6 -1.9 -0.5 -1.7 -1.2 -1.0 0.3 -1.5 -1.6 -1.9 -1.6 -0.3 -2.1 1.1 -1.9 -0.4
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.7 -0.1 -0.4 -0.2 0.8 0.0 0.0 -1.2 -0.2 -0.5 0.3 0.6 0.0 0.7 -0.8 0.6 -0.3 -0.2 -0.5 0.2 0.6 -1.1 -0.5 1.3
Hearing difficulty/problems: Yes 0.8 1.2 4.9 1.2 1.1 0.8 1.4 -0.1 0.0 -2.1 0.9 0.4 1.2 0.7 0.9 -0.6 -0.3 -0.0 1.6 0.9 0.3 0.4 1.8 0.8 2.2 0.8
Relative age of first facial hair 1.1 2.3 8.4 -2.1 1.2 1.1 -1.1 -0.5 0.0 1.1 1.1 1.6 1.5 -1.0 0.7 -1.6 0.5 -2.4 1.4 1.0 1.5 1.9 -1.7 2.4 1.0 -2.9
Other serious medical condition/disability diagnosed by doctor 1.4 1.8 6.0 -1.4 -1.7 -1.5 -1.3 -1.1 0.0 -1.1 -1.5 -1.6 -0.7 -0.5 -0.6 -0.3 -1.9 0.1 -1.4 -1.5 -1.6 -1.9 -1.4 -0.7 -2.5 0.5
Ever used hormone-replacement therapy (HRT) 1.5 2.0 7.8 -1.8 -1.2 -1.1 -2.8 0.1 0.0 1.2 -1.0 -1.0 -1.1 -1.2 -2.1 -1.9 -0.5 -1.2 -0.7 -1.1 1.9 -0.9 -2.0 1.2 0.2 -1.9
Ever had hysterectomy (womb removed) 1.2 1.4 7.9 -2.1 -0.2 -0.3 -1.0 -0.3 0.0 1.0 -0.3 -0.7 -0.7 -1.5 -1.7 -1.2 0.5 -1.7 -0.1 -0.4 2.8 0.1 -0.3 1.0 1.8 -1.4
Systolic blood pressure, automated reading 1.2 3.5 18.0 1.3 0.4 0.3 2.3 4.2 0.0 -2.1 0.3 -0.2 1.7 -0.5 1.3 2.9 -1.2 3.4 1.0 0.5 -1.3 1.2 1.6 -3.6 0.4 2.5
Eye problems/disorders: Diabetes related eye disease 1.3 1.4 4.4 -1.0 -1.4 -1.2 0.3 -0.3 0.0 -0.5 -1.3 -1.3 -1.4 1.0 -1.7 0.5 -1.8 0.5 -2.1 -1.3 -0.1 -1.8 -0.6 -0.8 -1.6 1.2
Angina 0.5 0.7 1.5 0.6 -1.2 -1.1 0.7 0.7 0.0 -0.0 -1.2 -1.2 -1.0 0.0 -1.2 0.7 -0.8 1.0 -1.0 -1.0 -0.1 -0.6 0.1 -0.8 -0.5 1.2
Medication for hormone replacement therapy 0.4 0.4 2.4 -1.5 0.0 0.1 -0.6 -0.2 0.0 0.1 0.1 0.4 -0.1 0.4 -0.1 0.4 -0.5 -0.9 -0.1 0.3 1.2 -0.0 -1.2 1.0 0.1 -1.1
Vitamin and mineral supplements 1.3 1.8 6.6 1.7 0.8 0.7 2.6 1.0 0.0 -2.3 0.8 0.4 1.5 0.0 1.4 0.2 -1.2 1.8 1.6 0.9 -1.0 0.7 1.6 -1.5 0.6 2.2
Supplements: Zinc 0.7 0.8 3.3 -1.1 0.2 0.3 -1.3 -0.2 0.0 -0.4 0.2 0.2 -0.9 -0.6 -1.4 -0.9 -0.3 -1.0 -0.5 0.1 1.7 -0.9 -1.7 0.4 0.3 -1.8
Medication: Co-codamol 0.4 0.5 1.5 0.1 -0.8 -0.9 0.8 -0.4 0.0 -0.5 -0.9 -0.9 -1.1 0.8 -0.8 0.9 -0.9 0.2 -1.2 -0.8 0.0 -0.6 0.3 -0.0 -0.3 0.5
Medication: Metformin 0.7 0.9 3.0 0.1 -1.4 -1.3 -0.3 0.4 0.0 0.1 -1.4 -1.7 -1.3 -0.9 -1.4 0.8 -0.1 0.6 -1.2 -1.4 -0.6 -1.1 0.7 -0.9 -1.0 0.4
Diabetes (father) 0.8 1.0 3.2 0.6 -1.4 -1.5 0.0 -0.3 0.0 -0.0 -1.5 -1.8 -1.8 -1.0 -1.1 0.5 0.3 0.8 -0.9 -1.6 -0.2 -1.3 1.0 -0.8 -0.5 0.4
Diabetes (mother) 0.7 0.9 4.4 -0.1 0.1 0.5 0.2 -1.5 0.0 -0.7 0.4 0.2 1.0 0.7 1.2 0.6 -1.2 0.9 0.3 0.4 -2.1 0.2 -0.1 -1.3 -2.0 1.1
Severe depression (siblings) 0.5 0.6 1.4 -0.2 -1.0 -1.0 -0.4 -0.1 0.0 0.4 -1.0 -1.0 -0.8 -1.0 -1.2 -1.1 -0.6 -0.2 -1.2 -1.0 0.3 -1.0 -0.0 0.7 -0.2 -0.3
Pack years adult smoking proportion 0.4 0.6 2.0 0.2 -1.2 -1.4 -0.7 0.4 0.0 0.6 -1.4 -1.3 -0.4 -0.2 -0.6 -0.6 0.5 0.5 -0.6 -1.4 -0.4 0.6 0.1 -0.4 -0.6 0.7
Impedance of leg (right) 1.3 6.2 14.6 -0.7 -3.5 -3.4 -3.7 -1.2 0.0 1.0 -3.5 -3.1 -3.5 -2.0 -2.3 0.4 -1.5 0.5 -3.3 -3.4 -2.0 -3.8 -1.5 -0.6 -3.3 0.8
Leg fat-free mass (left) 0.2 0.9 8.7 0.2 0.6 0.8 2.9 -1.5 0.0 -0.4 0.7 0.5 0.7 1.5 0.9 -0.4 0.3 -0.5 0.7 0.8 -1.0 0.5 1.1 0.5 0.1 0.9
Trunk fat percentage 1.0 4.0 11.6 -3.4 -2.5 -2.0 -1.1 -1.7 0.0 -0.8 -2.2 -2.7 -2.0 -2.1 -3.2 -0.2 -3.0 -1.3 -2.2 -2.2 0.6 -2.5 -1.6 -0.1 -2.2 -0.9
Hand grip strength (right) 1.2 3.3 16.0 2.6 1.7 1.5 2.8 1.5 0.0 0.4 1.5 1.9 1.1 4.0 1.9 0.4 2.0 1.3 1.5 1.7 0.8 1.9 2.7 -0.5 2.0 1.1
Townsend deprivation index at recruitment 0.8 1.1 5.8 0.6 0.7 0.3 0.1 -0.7 0.0 -0.5 0.3 0.2 0.7 0.6 0.4 -1.9 0.2 -0.7 1.8 0.4 1.7 1.1 1.8 1.1 2.4 -0.2
Current tobacco smoking 0.6 0.9 3.4 1.6 0.5 0.2 -0.2 1.8 0.0 0.9 0.3 0.2 0.7 0.0 1.1 -1.7 1.4 0.9 1.6 0.2 -0.1 1.4 1.0 -0.1 1.0 0.3
Average weekly fortified wine intake 0.5 0.6 2.9 0.8 0.3 0.3 -0.1 0.1 0.0 -0.0 0.3 0.3 0.2 -0.0 0.3 1.6 -0.1 1.7 -0.0 0.3 -0.4 0.5 1.7 -1.6 0.2 1.1
Maternal smoking around birth 2.3 3.3 6.0 -0.8 2.3 2.2 0.8 -0.9 0.0 2.0 2.2 2.1 1.5 -1.4 1.9 -2.0 2.5 -1.9 2.3 2.1 1.6 2.3 -1.6 1.7 1.4 -2.2
Fed-up feelings 1.4 2.5 8.5 0.2 1.8 1.6 1.2 -1.7 0.0 2.1 1.7 1.6 1.5 0.4 1.9 -1.5 2.9 -1.5 1.9 1.5 0.3 2.3 -0.5 2.1 1.7 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.9 0.0 0.3 0.4 1.0 0.3 0.0 -0.9 0.4 0.2 0.5 0.3 0.5 -0.4 -0.4 0.3 0.6 0.4 0.5 0.6 0.3 -0.6 0.4 0.5
Relative age voice broke 1.3 2.0 7.8 -1.7 0.9 0.8 -1.0 -0.3 0.0 1.8 0.9 1.1 0.3 0.2 0.2 -2.2 1.1 -2.1 0.8 0.8 2.4 1.2 -1.8 2.0 1.2 -2.8
Taking other prescription medications 3.4 5.3 10.2 -2.2 -2.9 -3.0 -3.1 -1.4 0.0 1.2 -2.9 -2.8 -3.1 -0.8 -3.2 -1.5 0.1 -2.6 -2.5 -3.0 0.3 -1.9 -2.8 2.4 -1.3 -2.2
Age when periods started (menarche) 0.9 2.2 7.2 0.9 1.7 1.2 -1.0 1.8 0.0 0.5 1.3 2.2 0.4 1.8 0.9 -1.2 0.9 -0.5 1.9 1.5 2.6 1.4 0.1 1.5 2.7 -2.0
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 2.4 -0.6 -0.2 -0.2 0.1 0.0 0.0 0.3 -0.3 -0.5 -0.7 -0.2 -0.7 -1.5 0.1 -0.8 0.1 -0.4 1.3 -0.4 -0.2 0.4 0.5 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 1.3 3.0 13.0 -0.8 1.2 1.9 1.2 1.0 0.0 -2.6 1.8 1.9 3.1 -0.4 2.1 0.1 -3.6 1.5 1.5 1.9 -1.5 0.1 -0.4 -2.2 -1.7 0.7
Tinnitus: Yes, but not now, but have in the past 2.0 2.1 4.9 -1.2 -2.2 -2.0 -1.5 0.1 0.0 -1.1 -2.0 -2.2 -1.3 -1.2 -2.1 -0.7 -1.7 0.2 -1.9 -2.0 -0.6 -1.9 -1.1 -1.0 -1.5 0.5
Qualifications: CSEs or equivalent 0.9 1.2 4.8 0.6 1.4 1.0 0.3 -0.1 0.0 -0.8 1.1 0.9 1.3 0.7 0.7 1.2 1.6 -0.2 1.4 0.9 1.1 2.0 0.8 0.4 2.2 -0.7
Serious illness, injury or assault to yourself 0.6 0.7 5.8 -1.1 -0.4 -0.3 -0.2 0.4 0.0 1.2 -0.4 -0.2 -0.4 0.1 -1.1 -2.4 0.5 -0.8 -0.2 -0.4 1.6 -0.1 -0.9 0.6 0.6 -0.7
High blood pressure 0.3 0.8 5.3 0.7 0.0 -0.3 0.1 0.3 0.0 0.5 -0.1 -0.1 1.0 -0.9 1.1 2.3 -0.3 0.6 0.5 -0.2 -2.1 1.2 -1.0 -0.2 -0.8 -0.2
Hayfever, allergic rhinitis or eczema 2.2 4.7 11.8 0.2 -3.3 -3.0 -0.9 -1.4 0.0 -0.9 -3.0 -3.1 -2.3 -1.0 -2.2 1.8 -1.5 0.6 -2.9 -3.0 -3.0 -2.7 -1.0 -1.0 -3.4 1.4
Multivitamins +/- minerals 1.3 1.7 5.0 -1.3 -1.7 -1.5 -1.9 -1.1 0.0 1.1 -1.6 -1.4 -1.7 -1.0 -1.6 0.7 0.1 -0.5 -2.2 -1.6 -0.3 -1.3 -1.2 0.3 -1.6 -0.8
Stomach or abdominal pain in last month 2.2 2.7 15.6 -1.0 -2.1 -1.8 -0.6 -0.9 0.0 1.3 -1.8 -1.8 -1.9 -0.6 -0.8 0.4 -0.5 0.4 -2.2 -2.0 -2.4 -2.2 -0.9 -1.1 -4.0 1.1
Supplements: Glucosamine 0.3 0.4 1.5 -1.1 0.2 0.6 0.8 -0.8 0.0 1.2 0.6 0.4 0.3 -0.1 0.4 -1.1 0.1 -0.9 -0.1 0.6 0.1 -0.1 -1.0 0.6 -0.1 -0.7
Diverticular disease/diverticulitis (self-reported) 1.5 1.7 5.7 -2.2 -1.3 -1.2 -2.2 -1.0 0.0 1.0 -1.3 -1.1 -0.8 -1.8 -1.4 -0.8 -0.4 -0.8 -1.4 -1.4 -0.3 -1.0 -2.4 0.4 -1.6 -1.3
Medication: Atenolol 0.7 0.9 4.0 1.5 0.6 0.2 1.1 2.0 0.0 -0.2 0.4 0.4 0.5 0.0 0.6 0.6 0.2 1.3 0.9 0.3 1.0 1.9 0.1 -0.9 1.5 0.5
Medication: Levothyroxine sodium 0.5 0.8 4.9 -0.3 0.7 0.3 -0.3 0.3 0.0 -0.5 0.5 0.6 0.0 -0.2 -0.4 -2.2 -0.4 -1.4 0.4 0.5 1.2 -0.5 -0.8 1.9 1.6 -1.0
Sitting height 0.2 1.7 5.9 2.0 -1.5 -1.5 0.0 -1.4 0.0 0.5 -1.6 -1.4 -1.2 -0.1 -0.2 -0.1 0.0 1.2 -0.9 -1.5 -2.4 -1.4 2.2 -0.3 -0.9 2.1
Chronic bronchitis/emphysema (father) 0.7 0.9 4.8 -2.2 -0.8 -0.7 -2.1 -0.6 0.0 0.6 -0.6 -0.6 -0.0 -1.2 -0.5 0.8 -0.5 -0.5 -0.2 -0.6 0.4 0.0 -1.5 0.0 -0.9 -1.0
High blood pressure (mother) 0.6 0.9 4.6 0.3 -0.5 -0.4 0.3 0.6 0.0 -1.0 -0.4 -0.3 -0.2 1.4 0.6 2.1 -1.0 1.2 -0.4 -0.4 -1.9 -0.3 -0.4 -0.9 -1.8 1.1
Body mass index (BMI) 0.2 0.7 3.0 -1.4 -0.3 0.1 1.7 -1.2 0.0 -1.7 0.0 -0.7 -0.1 -0.1 -1.2 0.3 -1.6 -0.2 -0.1 -0.1 0.9 -0.5 0.3 -0.8 -0.3 0.2
Impedance of leg (left) 1.1 5.4 12.9 -1.0 -3.2 -3.2 -3.6 -0.9 0.0 1.5 -3.2 -2.8 -3.5 -2.4 -2.5 0.1 -1.3 0.1 -3.1 -3.1 -1.0 -3.5 -1.5 -0.1 -2.8 -0.0
Leg predicted mass (left) 0.2 0.9 8.7 0.3 0.5 0.7 2.9 -1.5 0.0 -0.3 0.7 0.4 0.6 1.5 0.9 -0.4 0.4 -0.5 0.7 0.7 -1.2 0.4 1.1 0.5 0.0 0.9
Trunk fat mass 0.7 3.1 7.7 -2.6 -2.4 -1.8 0.1 -2.3 0.0 -1.1 -2.0 -2.5 -1.9 -1.2 -2.7 0.0 -2.8 -0.9 -2.0 -2.0 -0.1 -2.4 -0.9 -0.2 -2.1 -0.1
Waist circumference 0.9 3.2 8.8 -2.1 -2.4 -2.0 -0.3 -2.2 0.0 -1.6 -2.0 -2.7 -2.1 -0.9 -3.0 0.7 -2.6 -0.5 -2.2 -2.2 -0.3 -2.4 -0.2 -0.7 -1.9 0.3
Number of incorrect matches in round 1.6 2.7 6.7 -0.6 -2.5 -2.4 -1.2 -1.6 0.0 -0.1 -2.4 -2.6 -1.8 -0.5 -2.1 -0.1 -1.0 -0.7 -1.6 -2.5 -2.0 -2.1 -0.8 1.1 -1.9 0.0
Past tobacco smoking 0.8 1.4 7.3 0.8 0.5 0.7 2.7 -1.3 0.0 -1.7 0.7 0.5 0.8 -0.7 1.0 1.2 -1.7 1.3 0.4 0.8 -1.0 -1.0 1.9 -0.7 -0.6 1.7
Alcohol usually taken with meals 0.5 0.8 4.8 -0.4 -1.0 -0.6 0.1 -2.2 0.0 0.7 -0.7 -0.8 -1.3 -0.1 -0.6 0.8 0.4 -0.8 -1.4 -0.7 -1.1 -1.1 -0.4 0.5 -1.2 0.2
Nervous feelings 1.8 3.4 9.7 -1.1 -2.9 -2.7 -2.0 -1.2 0.0 0.6 -2.6 -2.5 -1.0 -1.9 -1.2 0.9 -1.3 0.3 -2.0 -2.7 -2.6 -1.6 -1.3 0.0 -3.1 0.6
Frequency of tenseness / restlessness in last 2 weeks 2.5 3.9 9.9 -0.0 -3.1 -3.0 -1.3 0.2 0.0 -0.0 -3.0 -3.0 -1.6 -0.6 -1.9 0.9 -1.7 1.6 -2.5 -3.1 -2.2 -1.4 0.3 -1.9 -2.5 2.4
Hearing difficulty/problems with background noise 0.7 1.2 3.6 1.1 1.2 1.0 1.6 -0.7 0.0 -1.9 1.1 0.7 1.3 1.4 1.3 0.7 0.3 0.4 1.3 1.0 -0.2 1.3 1.3 -0.4 1.5 0.5
Hair/balding pattern: Pattern 2 1.9 2.4 7.3 -0.6 -1.9 -1.9 -1.6 -1.5 0.0 -1.4 -1.8 -2.1 -2.1 -0.5 -2.0 1.4 -0.6 0.1 -2.7 -2.0 -0.5 -2.1 -0.4 -0.3 -2.2 0.4
Had menopause 1.1 1.3 4.8 -1.7 -1.2 -0.9 -1.2 -0.8 0.0 0.6 -0.9 -1.0 -0.3 -1.9 -1.4 -0.2 -2.2 -1.0 -0.8 -1.0 0.7 -1.0 -1.9 0.8 -0.9 -1.3
Had other major operations 0.2 0.3 1.7 -0.8 -0.3 -0.2 -0.6 -0.0 0.0 0.8 -0.1 -0.4 -0.5 -0.4 -0.9 -0.2 -0.0 -0.6 -0.5 -0.2 1.3 -0.2 -0.9 0.3 0.5 -0.6
Forced vital capacity (FVC) 1.0 3.8 10.6 1.3 3.0 3.0 1.6 -0.0 0.0 0.8 3.0 3.3 2.1 1.1 3.2 -2.0 2.0 -0.6 2.4 3.1 0.2 1.4 0.4 1.4 1.4 -0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 8.1 -0.6 0.7 1.2 0.5 1.8 0.0 -1.4 1.1 1.3 2.2 -0.7 1.5 -0.0 -2.9 1.4 0.8 1.2 -1.6 -0.2 0.0 -2.0 -1.7 0.9
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 2.6 -0.6 -0.2 -0.0 0.9 -0.9 0.0 1.4 -0.0 -0.1 0.1 -0.9 0.4 -1.6 0.7 0.1 0.1 -0.0 -0.6 0.3 -0.1 0.0 -0.1 0.3
Qualifications: None of the above 0.7 1.4 7.0 -0.1 1.0 1.0 0.2 -0.3 0.0 1.0 1.0 0.8 0.8 1.2 0.1 -2.6 1.0 -1.1 1.7 0.9 2.1 1.8 -0.6 1.0 1.8 -1.1
Financial difficulties in last 2 years 0.7 1.0 2.1 -0.7 1.4 1.5 0.4 -0.4 0.0 -0.2 1.5 1.3 1.1 0.8 0.8 -0.8 0.4 -0.8 1.4 1.2 1.4 1.4 0.2 0.9 0.8 -1.2
Mouth/teeth dental problems 0.2 0.3 3.6 0.5 0.4 0.4 1.9 0.4 0.0 -0.6 0.4 0.4 0.5 0.1 0.1 0.8 -0.0 -0.2 -0.0 0.3 -0.6 0.3 0.2 0.6 0.4 -0.1
Heart attack 1.0 1.3 5.8 2.4 0.2 -0.0 1.7 1.3 0.0 1.6 -0.0 0.2 0.1 1.2 0.7 -0.1 1.1 1.5 0.8 0.1 0.1 1.1 2.1 -0.4 1.3 1.5
Allergy 2.6 6.1 13.9 1.1 3.7 3.3 2.0 2.3 0.0 0.2 3.4 3.3 3.0 1.7 3.1 -0.8 2.0 0.7 3.4 3.4 2.0 3.3 2.1 -0.0 3.5 0.1
Pain all over the body in last month 0.4 0.4 3.7 0.7 -0.2 -0.2 1.3 -1.2 0.0 -1.9 -0.1 -0.7 0.1 0.5 0.0 0.2 -0.4 0.1 -0.2 -0.1 -0.3 0.1 0.3 -0.3 -0.4 0.9
Diabetes (self-reported) 2.6 4.1 12.8 -1.3 -3.0 -3.0 -1.9 0.2 0.0 -0.0 -3.0 -3.4 -2.8 -0.5 -3.6 0.5 -1.0 0.3 -2.9 -3.2 0.0 -2.1 -0.4 -0.9 -1.6 0.5
Hayfever/allergic rhinitis (self-reported) 1.7 2.2 6.1 1.4 -1.6 -1.4 0.3 1.0 0.0 -1.8 -1.5 -1.7 -1.5 0.6 -0.8 2.0 -1.0 2.2 -1.3 -1.5 -1.6 -1.4 1.1 -2.5 -1.7 2.0
Medication: Ramipril 2.8 3.6 11.1 1.9 2.3 2.0 1.1 1.1 0.0 1.8 2.0 2.0 1.9 1.9 2.3 -1.0 3.3 -0.4 2.8 1.9 0.5 3.3 0.4 1.0 2.6 -1.0
Medication: Simvastatin 0.5 0.8 3.3 1.4 -1.0 -1.1 -0.6 -0.1 0.0 1.4 -1.1 -1.4 -0.7 -0.0 -0.4 0.5 0.3 0.6 -0.8 -1.1 -0.7 -0.1 0.8 -0.3 -0.5 1.8
Fluid intelligence score 1.5 3.2 9.3 -1.9 -2.0 -1.6 -1.0 -3.0 0.0 0.2 -1.6 -1.4 -1.7 -2.0 -0.9 1.2 -2.1 -1.1 -2.5 -1.4 -2.4 -2.8 -1.7 1.4 -2.7 0.1
Illnesses of siblings 0.3 0.4 2.3 -0.1 0.1 -0.1 -0.4 0.4 0.0 -0.4 -0.2 -0.3 -1.0 0.1 -1.0 0.0 1.0 0.0 -0.9 -0.2 1.4 -0.0 0.8 -0.9 1.5 0.2
Neuroticism score 2.6 5.4 12.7 -2.4 -3.5 -3.2 -2.3 -2.6 0.0 1.9 -3.1 -3.1 -1.8 -1.8 -2.0 -0.9 -0.8 -0.8 -3.0 -3.4 -2.9 -1.8 -2.1 0.9 -3.6 0.7
Weight 0.2 1.1 6.6 -1.0 -0.9 -0.5 2.0 -2.6 0.0 -1.3 -0.6 -1.1 -0.8 0.3 -1.0 -0.0 -1.4 -0.6 -0.6 -0.6 -0.7 -1.2 0.5 0.0 -1.0 0.8
Impedance of arm (right) 1.1 5.1 22.9 -2.4 -2.7 -2.7 -4.8 0.4 0.0 0.2 -2.7 -2.4 -2.1 -2.8 -2.4 0.2 -2.0 -1.0 -2.5 -2.7 -0.6 -2.8 -2.8 0.6 -2.8 -1.3
Arm fat percentage (right) 0.7 2.9 10.5 -3.0 -2.0 -1.5 -0.4 -1.4 0.0 -2.0 -1.6 -2.3 -1.2 -1.4 -2.9 0.5 -3.2 -0.8 -1.6 -1.6 0.8 -2.0 -0.7 -0.6 -1.7 -0.4
Trunk fat-free mass 0.3 1.8 13.0 1.8 0.3 0.4 3.6 -2.0 0.0 -0.7 0.3 0.1 0.1 2.2 0.8 -0.1 0.9 0.4 0.4 0.4 -1.7 0.1 2.4 -0.1 0.5 2.0
Hip circumference 0.2 0.8 4.5 -0.4 -0.2 -0.1 2.1 -1.8 0.0 -1.8 -0.1 -0.6 -0.9 0.8 -0.9 0.6 -0.5 -1.0 0.0 -0.1 0.7 -0.6 0.8 0.8 0.6 0.1
Time employed in main current job 0.7 0.8 2.1 0.2 -1.3 -1.0 -1.1 -0.4 0.0 1.4 -1.0 -0.7 -0.5 -0.0 -1.1 0.4 -0.8 0.1 -1.3 -1.1 -0.8 -0.9 -0.9 -0.2 -1.4 -0.6
Alcohol intake versus 10 years previously 0.9 1.3 8.5 -0.5 1.1 0.9 2.9 -0.2 0.0 0.2 1.0 0.7 0.8 0.4 0.6 -1.3 0.7 -1.2 1.3 1.1 1.4 1.2 1.0 1.1 2.2 -0.2
Father’s age at death 1.7 2.3 8.2 -1.1 -1.9 -1.4 -0.8 -0.1 0.0 -1.1 -1.4 -1.8 -1.6 -1.6 -2.1 -0.6 -2.6 0.2 -2.1 -1.6 -0.2 -2.9 -1.3 -0.8 -2.0 0.4
Worrier / anxious feelings 2.2 4.1 11.2 -1.1 -3.1 -3.1 -2.1 -0.7 0.0 1.5 -3.0 -2.7 -1.8 -1.0 -1.7 0.7 -0.6 -0.1 -2.6 -3.1 -2.9 -1.6 -1.9 0.4 -3.3 -0.2
Frequency of tiredness / lethargy in last 2 weeks 1.9 3.1 7.4 -0.4 -2.6 -2.6 -2.0 -1.7 0.0 1.4 -2.6 -2.4 -2.1 -1.3 -1.9 0.5 0.0 0.2 -2.6 -2.7 -1.8 -1.6 -0.2 -0.4 -2.5 0.5
Falls in the last year 1.4 1.9 5.1 -0.7 -2.1 -2.1 -1.3 -1.0 0.0 0.9 -1.9 -2.2 -1.5 0.1 -1.3 -0.6 -0.9 -0.1 -1.5 -2.2 -1.4 -1.4 -0.0 -0.7 -1.9 0.9
Hair/balding pattern: Pattern 3 1.3 1.9 7.3 2.4 0.9 0.5 2.7 1.8 0.0 -0.2 0.5 0.5 0.8 1.3 0.9 0.3 0.8 1.9 1.3 0.6 0.3 1.3 2.3 -1.0 2.4 1.7
Number of live births 0.4 0.5 4.0 -0.9 -0.0 0.2 -1.3 -2.0 0.0 -0.3 0.1 -0.2 -0.3 -0.7 -0.7 1.0 -0.2 -0.5 -0.3 0.0 1.1 0.0 -0.2 -0.7 -0.4 -0.7
Forced expiratory volume in 1-second (FEV1) 1.9 6.6 21.2 1.4 3.8 3.8 2.7 0.6 0.0 0.1 3.8 3.9 3.6 1.4 4.6 -2.1 1.7 0.1 3.7 4.0 -0.3 2.1 1.1 0.9 1.7 0.5
Pulse rate 0.9 1.6 4.5 -0.7 -1.6 -2.0 -1.6 0.7 0.0 1.3 -1.9 -2.1 -1.6 -1.2 -1.2 0.9 1.2 0.7 -1.2 -2.0 -0.5 -0.1 -0.3 -1.0 -1.1 0.0
Happiness 1.3 1.6 4.5 -0.7 -2.0 -2.0 -0.9 -0.1 0.0 -0.4 -1.9 -2.1 -1.4 0.0 -1.8 0.2 -1.3 0.7 -1.5 -1.9 -0.2 -1.4 0.2 -0.5 -0.9 1.3
Noisy workplace 0.8 1.0 6.8 1.9 -0.3 -0.6 -0.1 1.3 0.0 -0.9 -0.6 -0.5 -0.3 1.1 -0.1 0.5 0.3 1.6 0.3 -0.6 -0.5 -0.0 2.6 -2.0 0.8 0.8
Qualifications: A levels/AS levels or equivalent 0.5 1.0 5.1 -0.3 0.6 0.9 1.5 -2.0 0.0 -1.0 0.9 0.9 0.4 -0.5 1.2 2.3 -1.2 0.2 -0.0 0.9 -1.1 -0.9 0.9 0.1 -0.9 0.8
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 2.2 1.1 -1.4 -1.5 -0.5 -0.7 0.0 0.2 -1.4 -1.5 -0.8 0.8 -0.3 0.9 0.3 0.6 -0.8 -1.3 -1.4 -0.9 0.3 -0.8 -1.1 0.3
Mouth/teeth dental problems: Dentures 0.1 0.2 1.8 0.2 -0.2 -0.3 -0.2 -0.7 0.0 1.4 -0.3 -0.3 -0.8 0.6 -0.1 -0.6 0.9 -0.3 -0.2 -0.2 0.2 -0.0 -0.3 0.5 -0.0 0.3
Asthma 1.5 2.9 8.8 -1.6 -2.3 -2.2 -1.7 -1.3 0.0 0.8 -2.2 -2.0 -3.0 -0.1 -2.8 0.6 -0.7 -1.1 -2.4 -2.4 0.1 -2.1 -1.5 1.0 -1.3 -0.8
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 5.6 -1.2 1.0 1.0 0.3 -2.4 0.0 -0.6 1.0 0.8 1.7 -0.7 0.9 -0.5 0.7 -1.7 1.4 1.0 0.8 1.9 -0.9 1.3 1.0 -1.3
Medication: Cholesterol lowering 0.5 0.8 3.9 1.7 -0.6 -0.6 -0.1 0.2 0.0 1.3 -0.6 -0.6 0.3 0.0 0.5 0.8 0.1 1.2 -0.3 -0.6 -1.8 0.4 0.6 -0.9 -0.8 2.0
Depression (self-reported) 0.9 1.1 4.8 -0.1 -0.5 -0.2 -0.7 -1.1 0.0 -1.0 -0.2 -0.2 0.3 -0.5 0.4 2.2 -2.0 1.6 -0.3 -0.4 -1.6 -0.8 0.8 -1.4 -1.5 1.4
Medication: Lansoprazole 2.3 2.6 6.6 -2.0 -1.8 -1.7 -2.4 -2.5 0.0 0.0 -1.6 -1.8 -1.3 -1.6 -1.3 0.3 -1.3 -1.6 -1.7 -1.9 -1.1 -1.2 -2.6 0.8 -2.1 -0.6
Prospective memory result 0.6 0.8 3.1 0.6 0.8 0.7 1.4 -0.1 0.0 1.3 0.7 0.7 0.5 0.8 1.0 -0.1 1.7 -0.5 1.1 0.7 0.4 1.6 -0.3 1.1 0.5 -0.8
Lung cancer (father) 0.2 0.2 1.3 -0.8 0.4 0.3 -0.2 0.9 0.0 -0.6 0.3 0.2 -0.5 0.8 0.1 0.3 -0.0 -0.4 0.2 0.3 1.1 -0.1 -0.4 -0.2 0.0 -0.6
Illnesses of mother 1.9 2.3 9.9 -0.5 1.9 1.6 0.8 0.4 0.0 0.5 1.7 1.5 1.1 -0.9 0.2 -1.1 2.3 -1.2 1.4 1.6 3.1 1.6 -0.3 0.9 2.9 -2.0
Forced expiratory volume in 1-second (FEV1), Best measure 3.1 10.0 32.6 0.9 4.7 4.9 3.8 0.2 0.0 -0.9 4.8 4.9 4.8 0.7 5.7 -2.0 1.3 -0.1 4.5 5.0 -0.0 3.0 0.5 0.6 1.5 0.2
Pulse wave Arterial Stiffness index 1.3 1.5 3.4 1.0 -1.2 -1.3 -0.5 1.8 0.0 1.5 -1.2 -1.0 -1.3 -0.6 -1.0 1.7 -0.9 1.6 -1.1 -1.3 -0.8 -0.8 0.9 -1.8 -0.8 1.7
Impedance of arm (left) 0.7 3.0 16.0 -2.0 -1.8 -1.8 -4.0 0.6 0.0 0.6 -1.9 -1.5 -1.1 -2.9 -1.4 -0.1 -1.3 -0.9 -1.7 -1.7 -0.3 -1.8 -2.5 0.8 -2.0 -1.3
Arm fat mass (right) 0.5 2.2 6.6 -2.0 -1.9 -1.5 0.6 -2.0 0.0 -1.4 -1.6 -2.3 -1.5 -0.4 -2.6 0.1 -2.3 -0.9 -1.5 -1.7 0.0 -1.9 -0.1 -0.1 -1.3 0.3
Trunk predicted mass 0.3 1.6 12.3 1.7 0.2 0.3 3.5 -2.0 0.0 -0.7 0.2 -0.0 0.0 2.1 0.7 -0.1 0.8 0.3 0.3 0.3 -1.7 0.0 2.3 -0.1 0.4 1.9
Standing height 0.2 2.2 12.3 1.1 -1.5 -1.4 1.1 -3.2 0.0 1.1 -1.5 -1.0 -1.5 0.7 0.4 -0.6 0.6 -0.7 -1.3 -1.3 -3.5 -1.6 0.3 1.7 -1.8 1.4
Length of working week for main job 0.8 0.9 2.2 0.0 1.0 1.0 -0.6 -0.0 0.0 0.0 0.9 1.2 0.8 1.2 0.5 -1.5 1.1 -1.0 1.2 0.9 1.1 0.9 -0.5 1.4 1.3 -0.7
Exposure to tobacco smoke at home 0.3 0.4 2.4 0.5 -0.3 -0.4 -0.3 0.4 0.0 -0.2 -0.4 -0.1 -0.6 1.2 0.0 -0.2 -0.3 0.9 0.5 -0.1 1.1 -0.2 1.6 -1.1 0.1 0.2
Breastfed as a baby 1.3 1.7 5.6 0.6 1.9 2.2 1.2 0.3 0.0 -0.7 2.2 2.4 1.7 1.4 1.7 -1.1 -0.6 -0.2 1.2 2.3 -0.3 0.1 0.1 0.6 0.3 -0.1
Tense / ‘highly strung’ 1.8 2.9 8.6 -1.7 -2.6 -2.5 -2.2 -2.0 0.0 0.4 -2.4 -2.1 -1.1 -0.4 -1.5 0.3 -1.4 -0.2 -2.1 -2.6 -1.4 -0.9 -1.8 0.2 -2.9 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.8 4.6 0.0 -1.9 -1.9 -1.2 -0.6 0.0 0.9 -1.8 -1.7 -1.5 -1.6 -1.2 0.4 -0.3 0.8 -1.7 -2.1 -1.9 -1.1 -0.2 -0.7 -2.0 0.7
Hair/balding pattern: Pattern 4 0.7 1.7 9.9 0.5 -1.9 -1.4 0.1 -0.9 0.0 1.6 -1.6 -1.3 -0.9 0.3 -0.2 0.8 -0.7 0.7 -1.1 -1.4 -3.1 -1.6 0.1 -0.7 -2.3 0.9
Birth weight of first child 0.3 0.5 2.6 0.7 -0.5 -0.4 -0.6 0.5 0.0 -1.3 -0.4 -0.5 0.2 0.0 -0.3 0.3 -1.6 1.0 -0.4 -0.5 -0.9 -0.7 0.1 -0.9 -1.1 0.4
Peak expiratory flow (PEF) 2.0 4.7 10.8 1.1 3.1 3.2 2.0 0.5 0.0 -1.9 3.3 3.1 3.3 1.6 2.9 -1.0 -0.0 0.4 3.1 3.3 1.2 1.9 1.9 0.3 2.4 0.7
Pulse wave reflection index 0.4 0.5 2.3 0.6 -0.4 -0.5 -0.7 0.7 0.0 -1.0 -0.4 -0.1 -0.8 1.2 -1.0 0.4 -1.5 0.1 -0.4 -0.5 0.4 -1.0 0.1 0.1 0.6 0.7
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.2 0.3 -0.8 -0.8 0.4 0.1 0.0 0.6 -0.7 -1.1 -1.0 0.0 -1.1 -1.1 -0.2 0.1 -0.6 -0.9 0.3 -0.5 0.4 -0.2 0.7 0.4
Loud music exposure frequency 0.5 0.5 2.9 -0.5 0.5 0.6 1.7 -0.3 0.0 -0.1 0.6 0.5 1.4 -1.2 0.9 -0.4 -0.1 -0.5 0.9 0.8 0.2 1.0 -0.6 0.4 0.3 -0.2
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 2.9 0.4 0.0 0.1 1.3 -0.7 0.0 -0.5 0.1 0.2 -0.4 0.3 0.7 1.3 -0.0 -0.4 -0.6 0.2 -1.7 -0.9 0.5 0.7 -1.1 0.3
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 2.1 -0.3 0.3 0.3 -1.4 -0.9 0.0 -0.7 0.2 0.4 1.2 0.4 1.0 1.1 -0.5 0.7 0.4 0.4 -1.0 0.6 0.1 -1.0 -1.1 0.4
Blood clot in the leg (DVT) 0.5 0.6 4.1 -1.5 -0.6 -0.3 -0.8 -1.0 0.0 0.0 -0.4 -0.3 0.0 -0.7 -0.8 -0.4 -0.8 -1.1 -0.4 -0.4 0.2 -0.1 -0.7 1.0 -0.7 -2.0
Medication: Paracetamol 0.5 0.8 2.8 -1.4 1.0 1.0 -1.1 0.1 0.0 0.1 1.1 1.0 0.8 0.2 0.7 -0.7 0.6 -0.6 1.7 1.0 1.3 1.0 -0.1 0.3 0.5 -1.5
Headache pain in last month 1.5 2.6 11.5 -1.9 1.6 1.4 -1.1 -1.5 0.0 1.1 1.6 1.6 0.8 -0.3 0.9 -1.8 1.6 -2.1 1.7 1.4 1.7 1.3 -2.0 2.1 0.7 -3.4
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 2.9 -1.4 -0.8 -0.7 -1.1 0.2 0.0 -1.3 -0.7 -0.7 -1.0 -0.8 -1.6 -1.5 -1.1 -0.8 -0.6 -0.7 1.4 -1.7 0.0 0.7 0.4 -1.1
Glaucoma (self-reported) 2.0 2.3 5.9 -1.1 -2.4 -2.2 0.4 -2.4 0.0 -0.7 -2.2 -2.4 -0.8 -0.7 -1.3 1.3 -1.2 -0.0 -1.6 -2.2 -1.8 -0.7 -1.6 0.2 -2.3 0.4
Gout (self-reported) 0.6 0.8 9.5 0.8 0.5 0.2 0.5 3.1 0.0 -0.1 0.3 0.4 0.5 0.4 -0.1 -1.4 0.7 0.2 0.2 0.3 0.4 1.2 -0.3 0.5 1.6 0.4
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 4.3 -1.2 0.3 0.1 -0.5 -0.1 0.0 -0.3 0.2 0.4 -0.2 -0.5 -0.6 -2.1 -0.4 -1.7 0.4 0.2 1.6 -0.5 -1.3 1.8 0.9 -1.6
Medication: Amlodipine 0.9 1.3 10.0 -1.8 -0.4 -0.4 -1.4 -0.6 0.0 0.9 -0.4 -0.4 0.1 -1.3 -0.3 -0.1 0.0 -1.5 -0.5 -0.6 -0.5 0.7 -3.2 1.1 -1.7 -2.0
Medication: Ventolin 100micrograms inhaler 3.4 4.3 10.0 -0.9 -3.1 -3.0 -2.3 -1.1 0.0 -0.1 -3.0 -3.1 -3.1 -1.4 -2.9 1.6 -1.4 0.4 -2.8 -3.2 -1.0 -2.8 -0.1 -0.7 -1.9 0.3
Birth weight 0.4 0.8 3.1 1.8 -0.8 -0.9 0.2 -0.6 0.0 -0.1 -0.8 -0.8 -0.8 0.9 0.0 0.7 0.3 1.5 -0.9 -1.0 -1.8 -0.8 0.7 -0.7 -0.7 1.3
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.3 -1.1 0.5 0.5 -1.1 0.8 0.0 0.7 0.6 0.4 0.1 -0.8 0.3 -0.7 0.4 -0.3 0.4 0.5 0.7 0.6 -0.4 -0.6 -0.3 -0.8
High blood pressure (siblings) 1.6 2.3 7.4 -0.6 1.4 1.8 1.2 -1.1 0.0 -0.5 1.9 2.0 2.4 0.4 2.0 -0.6 -1.1 -1.6 2.0 1.8 -0.8 0.8 -1.7 2.7 -0.5 -1.7
Forced vital capacity (FVC), Best measure 1.6 5.9 19.5 0.7 3.6 3.8 2.6 -0.6 0.0 0.3 3.8 4.0 3.4 0.6 4.4 -1.8 1.8 -0.6 3.2 3.9 -0.4 2.2 -0.1 1.0 0.8 -0.5
Body fat percentage 1.1 4.3 11.8 -3.2 -2.7 -2.1 -0.8 -1.9 0.0 -1.3 -2.3 -2.9 -2.0 -1.9 -3.3 0.1 -3.4 -0.9 -2.2 -2.3 0.5 -2.7 -1.3 -0.5 -2.3 -0.4
Leg fat percentage (right) 1.2 4.2 10.5 -1.9 -2.8 -2.2 -0.3 -2.0 0.0 -2.1 -2.4 -3.2 -2.1 -1.5 -3.0 1.0 -3.2 0.3 -2.2 -2.4 -0.3 -2.8 -0.3 -1.9 -2.4 1.0
Arm fat-free mass (right) 0.2 1.2 12.0 0.9 0.2 0.4 3.5 -2.4 0.0 0.2 0.4 0.1 0.0 1.4 0.4 -0.7 0.5 -0.2 0.2 0.4 -1.2 0.0 1.6 0.4 0.3 1.3
Exposure to tobacco smoke outside home 0.5 0.6 4.1 -0.8 -1.0 -0.7 -0.9 -0.4 0.0 -0.8 -0.7 -0.5 -0.5 0.4 -0.9 0.2 -2.0 -0.0 -1.0 -0.7 0.2 -1.4 0.2 -0.4 -0.7 0.5
Comparative body size at age 10 1.0 2.8 11.8 1.4 -0.2 0.3 3.3 0.9 0.0 -2.0 0.3 -0.3 0.4 0.8 0.4 0.9 -2.6 2.5 -0.2 0.2 -1.6 -1.2 2.0 -3.0 -1.1 3.4
Number of full brothers 0.4 0.5 1.8 -1.2 0.5 0.6 0.4 -1.3 0.0 -1.2 0.6 0.3 1.2 -0.2 0.2 0.3 -0.5 -0.1 0.7 0.7 1.3 1.2 0.6 -0.1 0.6 -0.3
Worry too long after embarrassment 4.0 6.8 17.2 -2.4 -3.7 -3.4 -3.5 -1.3 0.0 1.6 -3.4 -3.2 -1.9 -2.3 -2.7 2.0 -0.9 0.1 -4.0 -3.8 -2.7 -1.9 -2.5 -0.6 -4.1 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 5.2 -1.5 -1.2 -0.9 -1.4 -2.3 0.0 1.3 -0.8 -0.8 -0.1 -1.9 -0.4 -1.0 -0.9 -1.4 -0.7 -1.1 -1.0 -0.6 -1.9 1.2 -2.2 -1.1
Wheeze or whistling in the chest in last year 1.5 2.6 7.1 -0.3 -2.6 -2.6 -1.5 -1.1 0.0 0.3 -2.6 -2.6 -2.5 0.4 -2.0 0.6 -0.5 -0.2 -1.7 -2.7 -1.4 -1.5 -0.5 0.2 -1.8 -0.1
Number of children fathered 0.3 0.3 2.6 -0.9 0.2 0.5 1.6 0.4 0.0 0.5 0.5 -0.1 -0.2 -0.5 0.2 0.9 0.3 -0.4 -0.3 0.5 0.4 -0.1 -0.6 -0.5 -0.7 0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 4.9 -1.3 0.7 0.9 -0.1 -0.7 0.0 -0.2 0.9 1.2 1.0 0.4 -0.3 -1.0 -0.3 -1.6 0.1 0.7 1.0 0.5 -1.8 2.2 0.5 -2.2
Age at first live birth 1.2 2.1 8.4 0.0 -1.7 -1.6 -0.6 -0.2 0.0 0.7 -1.7 -1.2 -1.6 0.0 -0.7 2.1 -0.4 0.9 -2.5 -1.4 -2.9 -2.0 0.2 -1.0 -2.4 1.6
Pulse wave peak to peak time 1.4 1.7 5.2 -1.1 1.3 1.4 0.6 -2.3 0.0 -1.1 1.3 1.1 1.2 0.5 1.1 -1.9 1.1 -1.9 1.1 1.4 0.7 0.8 -1.1 2.1 0.7 -1.9
Health satisfaction 1.6 2.1 6.5 -1.2 -2.1 -1.8 0.1 -1.8 0.0 1.0 -1.9 -2.3 -1.8 -1.0 -1.0 0.5 -0.3 0.2 -1.7 -1.9 -1.4 -1.6 -1.0 -0.9 -2.5 1.0
Shortness of breath walking on level ground 2.5 2.9 7.1 -1.3 -2.6 -2.5 -1.5 -0.3 0.0 0.8 -2.5 -2.3 -2.2 -1.1 -2.0 -0.2 -1.3 -0.1 -1.9 -2.5 -1.2 -2.2 -1.7 0.0 -2.7 -0.5
Qualifications: College or University degree 0.9 2.7 9.8 -0.8 -1.3 -0.9 -1.4 -1.0 0.0 -0.8 -1.0 -0.8 -0.6 -1.1 0.1 3.1 -2.9 2.0 -1.6 -1.0 -2.5 -2.2 0.7 -1.8 -2.9 1.8
Eye problems/disorders: None of the above 4.2 4.8 11.4 1.2 3.0 2.6 1.0 1.6 0.0 1.7 2.6 2.8 2.3 1.1 3.1 -1.3 3.4 0.1 3.1 2.8 0.8 3.3 1.7 0.3 3.2 -0.4
Mouth/teeth dental problems: Loose teeth 0.5 0.6 2.4 -0.9 0.7 0.9 -1.3 -0.8 0.0 -0.0 0.8 1.1 0.7 0.7 0.2 -0.9 -0.5 -0.6 0.4 0.9 1.5 0.1 -0.4 -0.1 -0.0 -1.5
Emphysema/chronic bronchitis 2.8 3.1 7.9 -1.7 -1.7 -1.6 -2.8 -2.4 0.0 1.4 -1.6 -1.0 -1.9 -1.9 -2.2 -1.8 -1.6 -2.2 -1.5 -1.6 0.7 -1.7 -1.9 2.3 -1.1 -1.8
Medication for pain relief, constipation, heartburn 0.4 0.6 2.4 0.5 -0.9 -0.9 0.2 0.8 0.0 0.0 -0.9 -0.8 -0.8 -0.2 -1.0 0.1 -0.7 0.8 -1.6 -0.9 -0.9 -1.3 0.5 -0.4 -0.4 1.4
Neck or shoulder pain in last month 0.1 0.1 1.1 0.1 -0.3 -0.4 -0.4 0.1 0.0 0.0 -0.4 -0.2 -0.3 0.3 -0.2 -1.1 -0.2 -0.2 0.3 -0.3 0.5 -0.3 -0.4 0.4 0.2 0.2
Medication: Blood pressure 0.9 1.7 6.4 1.8 1.1 1.0 1.6 -0.4 0.0 0.8 1.0 0.9 1.5 0.0 2.1 2.5 1.7 1.0 1.0 1.0 -1.6 2.4 -0.2 -0.7 -0.2 0.5
Angina (self-reported) 0.5 0.7 1.7 0.7 -1.1 -1.0 0.9 0.7 0.0 0.2 -1.1 -1.1 -1.0 0.2 -1.1 0.8 -0.5 1.1 -1.0 -0.9 -0.1 -0.3 0.1 -0.9 -0.5 1.3
Migraine (self-reported) 0.6 0.7 9.1 -1.0 -0.3 -0.3 -3.0 -0.9 0.0 0.9 -0.2 -0.2 -0.5 -0.9 0.1 -0.1 0.5 -0.8 -0.1 -0.4 -0.1 -0.0 -1.0 -0.2 -0.6 -0.6
Medication: Ibuprofen 0.9 1.1 7.5 -1.8 0.5 0.5 -0.1 -2.7 0.0 -0.3 0.4 0.2 1.3 -1.1 0.6 0.2 0.7 -1.6 0.8 0.5 0.5 1.7 -0.5 1.0 0.3 -1.1
Medication: Allopurinol 1.2 1.5 8.0 -0.2 1.1 0.7 -0.2 2.8 0.0 0.8 0.9 0.9 1.3 -0.1 0.3 -2.0 1.5 -0.6 0.8 1.0 1.5 1.9 -1.2 1.0 2.1 -0.9
Medication: Omeprazole 0.4 0.5 3.1 0.5 -0.6 -0.5 1.0 -0.4 0.0 0.3 -0.6 -0.5 -1.2 1.8 0.0 -0.7 0.3 0.3 -0.4 -0.6 -0.9 -0.7 -0.3 -0.2 -1.0 0.3
Medication: Seretide 50 evohaler 0.4 0.4 2.3 0.1 -0.5 -0.6 -0.4 -0.0 0.0 -0.5 -0.6 -0.6 -0.2 1.4 0.2 1.1 1.0 0.5 0.1 -0.6 -1.5 0.5 0.2 -0.5 -0.4 0.9
Mean time to correctly identify matches 3.1 5.9 19.3 -2.7 -3.3 -3.2 -3.4 1.1 0.0 0.7 -3.2 -2.9 -2.6 -1.1 -4.4 -1.4 -3.0 -1.1 -3.2 -3.2 0.5 -2.8 -1.7 1.1 -1.8 -0.4
Heart disease (mother) 1.3 1.6 7.3 -1.4 -1.4 -1.0 -1.7 -0.9 0.0 -1.3 -1.0 -1.1 -0.5 0.2 -1.2 -0.2 -2.7 -0.3 -1.2 -1.1 -1.0 -2.0 -1.8 0.5 -2.0 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.6 3.1 6.8 1.8 2.0 2.0 1.6 2.2 0.0 -1.7 1.9 1.9 1.0 2.6 1.8 1.8 0.7 1.7 2.0 2.1 1.3 1.3 2.3 -1.9 2.1 0.9
Whole body fat mass 0.7 2.8 7.3 -2.2 -2.2 -1.7 0.5 -2.2 0.0 -1.4 -1.9 -2.5 -1.8 -0.8 -2.6 0.2 -2.7 -0.6 -1.9 -1.9 -0.1 -2.3 -0.6 -0.5 -2.0 0.4
Leg fat mass (right) 0.7 2.6 6.5 -1.4 -2.2 -1.8 0.7 -2.4 0.0 -1.2 -1.9 -2.5 -2.0 -0.6 -2.3 0.5 -2.1 -0.0 -1.8 -1.9 -0.6 -2.3 0.0 -1.0 -2.0 1.0
Arm predicted mass (right) 0.2 1.3 11.5 1.1 0.1 0.3 3.4 -2.3 0.0 0.0 0.3 0.0 -0.2 1.6 0.5 -0.6 0.2 0.1 0.1 0.3 -1.4 -0.3 1.8 0.0 -0.0 1.6
Pulse rate, automated reading 1.3 4.2 11.6 -0.9 -3.0 -3.0 -2.3 -0.9 0.0 0.5 -3.0 -3.4 -2.6 -1.3 -2.4 0.9 -0.2 0.7 -2.8 -3.2 -2.0 -2.0 -0.5 -0.9 -2.7 0.6
Alcohol intake frequency. 0.7 1.6 6.9 -0.0 -1.6 -1.8 0.9 -2.6 0.0 0.6 -1.7 -1.8 -1.5 0.7 -1.1 -0.9 0.6 -1.5 -0.8 -1.6 -1.0 -1.0 -0.5 1.9 -0.4 -0.4
Comparative height size at age 10 0.6 3.2 10.6 2.5 -1.4 -1.3 3.1 -1.4 0.0 -0.5 -1.4 -1.4 -2.1 1.4 -0.3 0.2 -0.3 1.1 -1.9 -1.1 -3.3 -2.9 2.2 -0.3 -1.0 3.2
Number of full sisters 0.3 0.4 2.0 0.8 0.4 0.4 -1.4 -1.0 0.0 -0.5 0.4 0.5 0.5 0.4 0.1 -0.1 -0.5 -0.0 0.8 0.4 0.6 -0.2 1.0 0.4 1.2 0.1
Suffer from ‘nerves’ 1.3 2.0 5.6 -0.6 -2.4 -2.2 -0.8 -0.5 0.0 0.9 -2.1 -2.0 -1.3 -0.9 -0.9 0.7 -0.9 1.0 -1.7 -2.1 -1.8 -1.1 -0.7 -0.8 -2.2 1.4
Overall health rating 0.8 1.6 4.3 -0.6 -2.0 -1.8 -0.2 -0.9 0.0 1.8 -1.9 -2.0 -1.9 0.2 -1.0 -0.8 0.0 0.0 -1.0 -2.0 -1.6 -1.0 -0.5 -0.3 -2.1 0.5
Chest pain or discomfort 1.9 2.7 7.6 1.2 -2.2 -2.2 -0.4 -1.1 0.0 0.2 -2.2 -2.3 -1.8 -0.3 -0.5 1.6 -0.4 1.8 -1.6 -2.1 -2.8 -1.3 -0.1 -1.6 -2.6 2.1
Had major operations 3.6 4.3 10.8 -2.1 -2.8 -2.4 -2.4 -0.7 0.0 -0.5 -2.5 -2.2 -2.3 -1.4 -3.1 0.3 -3.3 -0.2 -3.2 -2.5 -0.0 -3.1 -1.3 -0.7 -2.4 0.2
Age at last live birth 1.8 2.6 7.5 1.1 -1.6 -1.6 -0.1 1.2 0.0 -0.4 -1.7 -1.4 -1.1 -0.4 -0.9 2.2 -0.6 2.3 -2.2 -1.4 -2.4 -1.7 1.2 -2.6 -1.7 2.7
Family relationship satisfaction 0.2 0.3 1.2 -0.3 -0.2 -0.2 -0.0 0.9 0.0 -1.1 -0.3 -0.3 0.4 0.4 -0.5 -0.5 -0.4 0.7 0.4 -0.3 0.9 -0.1 -0.2 -0.7 0.5 0.6
Leg pain on walking 0.5 0.6 2.9 -0.9 -0.8 -0.6 0.2 -1.0 0.0 -1.1 -0.7 -0.7 -0.4 -0.0 -0.6 -0.6 -1.7 -0.5 -0.7 -0.6 -0.8 -1.4 0.2 -0.3 -0.9 0.1
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.6 4.6 -0.3 -1.7 -1.8 -1.0 0.3 0.0 1.5 -1.8 -1.8 -2.1 -0.6 -2.0 1.3 0.3 -0.1 -1.7 -1.9 0.1 -1.2 0.2 -0.4 -1.0 -0.4
Commuting to job workplace: Car/motor vehicle 1.3 1.5 8.2 -1.9 0.4 0.6 -0.9 -1.2 0.0 0.2 0.6 0.5 1.6 -1.5 0.6 0.2 0.3 -1.9 0.5 0.6 -0.0 1.4 -2.9 0.7 -0.8 -2.5
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.9 0.3 -0.2 -0.3 0.4 -0.3 0.0 -0.9 -0.2 -0.2 -0.5 -0.2 -0.2 1.0 -0.8 -0.0 -0.4 -0.3 -0.6 -0.6 0.8 0.3 -0.1 0.3
Medication: Aspirin 0.8 1.0 3.6 1.5 -1.0 -0.9 -0.5 0.5 0.0 -0.0 -1.0 -1.2 -0.9 -0.4 -0.6 1.4 -0.8 1.9 -0.7 -1.1 -0.7 -0.4 1.0 -1.7 -1.0 1.5
Supplements: Vitamin C 1.2 1.5 6.0 -1.5 1.2 1.3 -0.3 -1.7 0.0 0.2 1.2 1.2 0.5 0.2 0.2 1.8 1.2 -1.3 0.5 1.1 2.1 1.5 -0.7 0.4 1.0 -2.5
Knee pain experienced in last month 0.4 0.6 3.0 -1.7 -0.4 -0.5 -0.4 -0.8 0.0 -0.4 -0.5 -0.5 -0.1 0.6 -0.8 -1.2 0.3 -1.2 -0.3 -0.5 1.0 0.4 -1.0 1.2 0.4 -1.3
Hypertension (Self-reported) 0.3 0.7 4.5 0.6 -0.2 -0.5 0.2 0.4 0.0 0.8 -0.3 -0.3 0.9 -0.6 1.0 2.1 -0.0 0.6 0.5 -0.4 -2.1 1.3 -1.2 -0.1 -0.8 -0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.5 1.8 5.1 0.5 -2.0 -2.0 0.4 -0.8 0.0 0.1 -2.0 -2.0 -2.3 0.2 -1.8 1.2 -0.3 0.8 -1.6 -2.2 -0.9 -1.4 0.2 -0.4 -0.8 1.4
Illnesses of father: Heart disease 1.9 2.7 7.3 0.9 -2.2 -2.2 -1.2 0.4 0.0 0.3 -2.2 -2.2 -2.7 0.3 -1.7 0.2 -0.9 1.5 -2.1 -2.3 -1.4 -2.5 1.0 -1.0 -1.6 1.9
Illnesses of siblings: Diabetes 1.2 1.5 5.3 -0.3 -1.7 -1.4 0.8 -0.8 0.0 -0.1 -1.5 -1.8 -1.0 -1.1 -0.8 0.5 -1.5 0.7 -1.4 -1.4 -1.7 -1.3 0.7 -1.0 -2.3 1.3
Smoking status: Previous 0.7 1.0 3.0 -1.0 -0.3 -0.4 -1.7 0.3 0.0 0.7 -0.4 -0.3 -0.8 1.2 -1.3 -0.3 1.1 -1.6 -0.6 -0.5 1.4 0.7 -1.7 0.8 0.8 -1.6
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.1 8.1 0.3 1.6 1.5 2.4 -0.9 0.0 1.1 1.6 1.4 1.8 -0.1 2.9 -0.1 2.4 -0.5 1.5 1.7 -1.7 1.9 0.8 0.3 0.1 0.9
Whole body fat-free mass 0.2 1.4 12.3 1.2 0.5 0.6 3.5 -1.9 0.0 -0.5 0.6 0.3 0.3 1.9 0.9 -0.3 0.7 -0.0 0.6 0.6 -1.4 0.2 1.9 0.3 0.4 1.5
Leg fat-free mass (right) 0.2 1.2 10.1 0.3 1.0 1.1 3.2 -1.2 0.0 -0.1 1.1 0.9 1.0 1.5 1.1 -0.6 0.7 -0.7 1.1 1.1 -0.6 1.0 1.2 0.8 0.6 0.4
Arm fat percentage (left) 0.5 2.1 9.7 -3.1 -1.5 -0.9 0.0 -1.2 0.0 -1.7 -1.1 -1.8 -0.6 -1.6 -2.4 0.1 -2.9 -1.0 -1.2 -1.1 1.0 -1.4 -1.0 -0.4 -1.4 -0.6
Average weekly red wine intake 0.8 1.2 3.0 -0.8 -1.5 -1.3 -1.6 -1.3 0.0 -0.3 -1.4 -1.3 -0.9 -0.1 -1.1 0.7 -1.1 -0.4 -1.7 -1.2 -1.1 -1.5 -0.5 0.3 -1.7 0.6
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.8 -0.1 0.6 0.5 -1.2 -0.5 0.0 -0.5 0.5 0.5 0.8 0.2 1.0 -0.2 0.1 -1.1 1.3 0.5 -0.8 1.0 -0.2 0.8 0.3 -1.0
Mood swings 0.4 0.8 4.0 -1.6 -0.3 -0.1 -0.2 -1.2 0.0 2.0 -0.0 -0.1 -0.1 -0.2 -0.1 -1.9 0.9 -1.4 0.0 -0.3 -0.2 0.2 -1.2 1.2 -0.6 -0.5
Loneliness, isolation 0.8 1.1 2.6 -0.4 -1.4 -1.3 0.4 -0.8 0.0 -0.1 -1.3 -1.5 -0.7 -1.3 -1.5 -1.6 -0.1 -0.7 -1.4 -1.2 -0.2 -1.4 -1.4 1.1 -0.3 0.4
Long-standing illness, disability or infirmity 2.0 3.0 5.9 -1.8 -2.2 -2.0 -2.4 -1.1 0.0 1.4 -2.1 -2.2 -2.0 -0.1 -2.4 -1.7 -0.3 -1.5 -2.1 -2.2 -0.8 -1.8 -1.9 0.9 -2.4 -0.8
Ever had bowel cancer screening 1.6 1.8 6.2 -2.5 -0.7 -0.4 -2.3 -1.7 0.0 0.7 -0.5 -0.4 -0.1 -1.5 -0.9 -1.0 -0.5 -2.5 -1.0 -0.5 0.1 -0.4 -2.2 1.7 -1.2 -2.3
Diabetes diagnosed by doctor 3.3 5.4 14.2 -1.3 -3.6 -3.4 -2.1 -0.3 0.0 0.5 -3.5 -3.7 -3.4 -0.5 -3.8 -0.1 -1.4 0.2 -3.4 -3.5 -0.6 -3.0 -0.7 -0.7 -2.4 0.8
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 5.1 1.1 1.2 0.8 0.9 1.4 0.0 1.3 0.9 0.8 0.5 0.9 1.6 0.2 2.3 0.1 1.2 1.0 -0.1 1.5 1.0 -0.1 0.9 -0.1
Friendships satisfaction 0.8 1.0 2.4 -0.5 -1.3 -1.1 -0.4 -1.3 0.0 -1.5 -1.1 -1.5 -1.2 0.3 -1.1 -1.0 -0.9 0.2 -1.1 -1.1 -0.1 -1.6 -0.5 -0.5 -0.7 0.7
Qualifications: nursing, teaching 0.5 0.7 3.1 -0.9 0.2 0.6 0.0 -1.2 0.0 -0.2 0.6 0.5 0.8 -1.8 0.9 1.3 -1.5 0.0 -0.2 0.6 -0.8 -0.5 -0.3 -0.8 -1.6 -0.5
Commuting to job workplace: Walk 1.0 1.0 2.6 0.7 -1.2 -1.2 0.2 -0.0 0.0 0.6 -1.3 -1.1 -1.4 0.9 -0.8 1.1 -0.0 0.7 -1.3 -1.2 -1.6 -1.4 1.4 -0.3 -0.9 1.3
Eye problems/disorders: Cataract 2.2 2.5 6.6 -0.3 -2.5 -2.5 -1.3 -0.1 0.0 -0.3 -2.4 -2.4 -2.6 -0.3 -2.2 -0.7 -1.0 -0.1 -2.2 -2.5 -0.4 -2.2 -1.2 -0.1 -1.5 0.0
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 2.4 -1.2 -0.9 -0.6 -1.4 -0.5 0.0 -0.2 -0.7 -0.8 -0.5 -1.6 -0.6 0.1 -1.1 0.1 -0.5 -0.7 0.1 -1.0 -1.0 -0.2 -1.1 0.0
Medication for cholesterol 0.3 0.4 2.8 0.4 0.1 0.3 0.7 -0.8 0.0 0.0 0.1 0.3 -0.1 -0.1 0.4 0.1 0.5 1.1 -0.3 0.2 -0.9 -0.4 0.6 -1.7 -0.8 1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 1.6 -0.6 -0.1 0.0 -0.3 -0.1 0.0 -0.9 0.0 -0.1 0.1 0.2 -0.5 0.4 -1.3 -0.3 0.2 0.0 1.0 -0.1 -0.2 -0.0 -0.4 -0.8
Back pain experienced in last month 0.5 0.7 3.6 -0.9 -1.2 -0.9 -0.7 -0.6 0.0 0.7 -1.0 -1.0 -0.7 0.3 -0.5 -0.3 -0.5 -0.9 -0.6 -1.0 -1.1 -1.0 -0.7 0.9 -1.9 -0.4
Mineral and other dietary supplements 0.8 1.0 4.2 1.7 -0.8 -1.0 0.2 0.8 0.0 -0.9 -0.9 -1.0 -0.3 -0.4 -0.4 0.6 -0.6 2.0 -0.4 -1.0 -0.5 -0.7 1.7 -1.6 -0.2 1.9
Breast cancer (self-reported) 1.2 1.4 5.7 -0.2 1.5 1.3 0.1 1.9 0.0 0.3 1.4 1.4 0.5 0.7 -0.0 -2.3 0.7 -0.9 1.1 1.4 1.9 0.6 -0.1 1.0 2.4 -0.5
Asthma (self-reported) 1.5 3.0 9.6 -1.1 -2.5 -2.4 -1.7 -0.9 0.0 1.0 -2.4 -2.1 -3.1 0.0 -2.7 0.6 -0.7 -0.7 -2.5 -2.5 -0.3 -2.3 -1.2 0.8 -1.4 -0.5
Osteoporosis (self-reported) 0.7 0.8 3.2 0.1 -0.6 -0.9 -1.8 0.1 0.0 0.6 -0.8 -0.7 -1.3 1.2 -1.0 -0.6 1.4 -1.1 -0.1 -0.8 1.2 -0.3 -0.6 1.1 1.0 -0.8
Osteoarthritis (self-reported) 1.3 1.7 5.4 -1.1 0.9 0.8 0.6 -1.1 0.0 0.9 0.9 0.7 1.2 -0.5 0.2 -2.3 1.0 -2.2 0.8 0.8 0.4 1.4 -2.3 2.3 1.2 -2.2
Medication: Aspirin 1.0 1.3 4.3 1.5 -1.1 -1.0 -0.5 0.8 0.0 -0.2 -1.1 -1.2 -1.1 0.1 -0.7 2.0 -0.9 2.1 -0.9 -1.1 -0.5 -0.6 1.3 -1.9 -1.0 1.6
Medication: Gliclazide 3.9 4.4 10.4 -0.2 -3.0 -3.0 -2.0 0.7 0.0 -0.5 -3.1 -3.2 -2.9 0.0 -2.8 1.1 -1.5 1.2 -2.8 -3.1 -1.0 -2.7 1.0 -1.8 -2.3 1.6
Illnesses of father: None of the above (group 1) 1.5 1.8 8.0 -2.6 0.5 0.8 -1.3 -1.6 0.0 -0.4 0.7 0.9 1.7 -0.4 0.6 -1.0 -0.8 -2.8 0.4 0.8 0.4 1.1 -2.2 1.9 -0.2 -2.2
Smoking status: Current 0.7 1.0 3.6 1.2 0.6 0.2 -0.3 1.9 0.0 1.3 0.4 0.3 0.9 0.0 1.3 -1.9 1.6 0.6 1.8 0.3 -0.3 1.7 0.5 0.1 0.8 0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.2 4.6 10.8 0.1 3.0 2.9 1.7 2.8 0.0 0.6 3.0 3.1 3.1 0.0 3.1 -2.2 1.3 0.4 2.9 3.3 1.8 2.4 0.1 -0.4 2.0 -0.0
Whole body water mass 0.2 1.4 11.9 1.1 0.3 0.5 3.5 -2.0 0.0 -0.5 0.4 0.2 0.3 1.9 0.7 -0.2 0.6 -0.1 0.4 0.5 -1.5 0.2 1.9 0.2 0.3 1.6
Leg predicted mass (right) 0.2 1.2 9.9 0.2 1.0 1.1 3.1 -1.3 0.0 -0.1 1.1 0.9 1.0 1.4 1.0 -0.6 0.7 -0.7 1.1 1.1 -0.6 0.9 1.2 0.9 0.6 0.4
Arm fat mass (left) 0.4 1.6 4.8 -2.2 -1.5 -1.0 0.9 -1.9 0.0 -1.3 -1.1 -1.8 -1.0 -0.4 -2.1 -0.1 -2.2 -0.8 -1.3 -1.2 0.2 -1.5 -0.2 -0.2 -1.2 0.2
Number of self-reported non-cancer illnesses 1.3 2.3 8.0 -1.2 -1.9 -1.9 -2.3 -0.8 0.0 0.9 -1.8 -1.7 -1.5 -0.5 -1.5 0.0 -0.9 -1.4 -1.5 -1.9 -0.6 -1.0 -2.8 1.6 -1.6 -1.5
Average weekly champagne plus white wine intake 0.3 0.4 3.2 -0.3 0.6 0.5 -0.0 0.1 0.0 0.1 0.4 0.5 -0.1 -0.8 -0.2 0.2 0.6 -0.6 -0.2 0.4 1.4 0.1 -0.0 1.1 1.8 -0.3
Miserableness 0.3 0.5 2.9 -0.8 -0.6 -0.5 0.4 -1.7 0.0 0.5 -0.5 -0.6 -0.6 -0.4 -0.9 -1.4 0.1 -0.7 -0.7 -0.7 -0.1 -0.2 -0.3 0.7 -0.2 -0.1
Guilty feelings 2.1 3.2 12.6 -1.3 -2.4 -2.0 -1.6 -2.4 0.0 1.9 -2.0 -1.8 -1.3 -1.4 -0.7 0.1 -0.7 0.0 -2.1 -2.3 -2.9 -1.2 -2.1 -0.1 -3.6 0.9
Wears glasses or contact lenses 0.5 0.6 2.1 -0.6 -1.2 -1.2 -1.3 0.2 0.0 0.2 -1.2 -1.4 -0.2 -1.1 -1.0 0.6 -0.6 -0.4 -0.9 -1.1 -0.6 -0.3 -0.5 -0.0 -0.3 0.2
Ever taken oral contraceptive pill 1.6 1.8 4.6 -0.6 1.9 1.8 0.3 0.0 0.0 0.8 1.9 1.6 1.3 -1.2 1.7 -1.8 2.1 -0.9 1.9 1.8 0.5 1.6 -0.9 0.2 0.9 -1.4
Hearing aid user 0.9 1.0 6.2 -0.7 -0.4 -0.5 -1.2 0.1 0.0 0.9 -0.6 -0.6 -0.6 -1.0 -1.6 -1.7 0.4 -1.1 -0.2 -0.5 2.5 0.0 -0.5 0.9 1.4 -1.3
Mother’s age at death 0.7 0.9 4.5 0.3 -1.0 -0.8 0.2 -0.9 0.0 -1.0 -0.9 -0.8 -0.5 -1.2 -0.4 1.7 -2.1 0.7 -0.7 -0.8 -0.7 -1.0 0.3 -0.7 -1.0 1.1
Financial situation satisfaction 0.6 0.7 1.9 -1.3 -1.1 -1.1 -0.9 -1.4 0.0 -0.1 -1.0 -1.2 -0.4 -1.2 -1.1 0.1 -0.1 -0.9 -0.7 -1.0 0.1 -0.2 -0.7 0.6 -0.9 -0.1
Tinnitus: Yes, now most or all of the time 1.0 1.2 3.3 0.7 1.5 1.4 1.8 -1.1 0.0 -1.6 1.4 0.9 0.5 -0.3 1.5 1.0 0.6 -0.2 1.4 1.4 1.2 0.5 0.6 0.3 1.4 -0.1
Commuting to job workplace: Public transport 0.9 1.1 4.7 1.5 0.2 0.3 1.2 0.7 0.0 -2.2 0.2 0.2 -0.2 0.7 -0.2 0.3 -1.5 1.8 -0.1 0.2 0.6 -1.2 1.7 -1.1 1.0 2.0
Eye problems/disorders: Glaucoma 0.9 1.1 3.0 -0.3 -1.6 -1.4 1.0 -0.9 0.0 -0.8 -1.5 -1.7 -0.1 -0.7 -1.2 1.0 -0.7 0.1 -1.2 -1.5 -1.0 -0.3 -1.5 0.4 -1.1 0.8
Medication: Blood pressure 0.2 0.4 1.8 0.0 -0.3 -0.6 -0.1 0.8 0.0 0.3 -0.4 -0.6 0.3 0.3 -0.2 -0.1 -0.2 -1.0 0.3 -0.6 -0.6 0.8 -0.6 1.3 0.3 -1.2
Pain type(s) experienced in last month: Hip pain 0.4 0.5 2.6 -0.6 -0.6 -0.5 -1.1 -0.4 0.0 -1.0 -0.6 -0.4 0.1 0.9 -0.7 0.0 -1.6 -1.1 -0.7 -0.4 -0.6 -0.8 -0.4 1.0 -0.5 -0.0
Supplements: Fish oil (including cod liver oil) 0.6 0.8 3.5 -0.9 0.9 1.1 0.2 -0.8 0.0 0.8 1.0 1.0 0.4 0.2 0.8 -0.1 0.9 -1.4 0.8 1.2 0.4 0.9 -1.2 1.0 0.0 -1.9
High cholesterol (Self-reported) 0.3 0.5 3.5 1.9 -0.8 -1.1 0.4 0.1 0.0 0.2 -1.0 -1.3 -1.0 0.1 -0.7 0.5 0.5 0.3 -0.7 -0.9 -0.2 -0.3 0.1 0.4 0.4 0.7
Medication: Bendroflumethiazide 0.6 1.0 4.3 0.4 1.0 1.1 0.8 0.0 0.0 -0.7 1.1 0.9 2.1 -1.1 1.5 1.2 -0.6 0.4 1.3 1.1 -1.4 1.1 -0.0 -0.7 -0.6 -0.3
Medication: Paracetamol 0.4 0.6 3.2 -1.8 0.3 0.6 -1.2 -0.4 0.0 -0.1 0.6 0.6 0.4 0.3 0.3 -0.3 -0.3 -0.8 1.2 0.6 0.7 0.2 -0.4 0.3 -0.5 -1.7
Medication: Lisinopril 0.5 0.7 4.3 -1.4 -0.1 0.1 -0.0 -2.1 0.0 -1.1 0.1 0.0 1.4 -0.6 0.5 1.1 -1.5 -0.1 0.1 0.1 -0.4 0.6 0.1 -0.2 -0.9 -0.1
Medication: Atorvastatin 1.1 1.3 4.3 2.1 0.4 0.5 1.9 1.1 0.0 -0.8 0.4 0.4 0.6 1.6 0.5 0.6 0.0 2.1 0.7 0.5 0.0 0.8 1.9 -1.7 1.2 1.8
Illnesses of father: High blood pressure 2.4 3.0 11.2 3.3 -1.2 -1.5 0.4 2.6 0.0 0.1 -1.4 -1.5 -1.9 1.4 -1.0 0.5 0.1 3.2 -0.8 -1.4 -0.8 -1.4 3.0 -2.7 -0.1 2.2
Alcohol drinker status: Never 0.5 0.6 2.9 0.7 0.3 0.3 0.6 -1.0 0.0 -1.5 0.3 0.4 0.3 0.5 1.4 1.7 -0.8 0.3 0.8 0.5 -0.8 -0.4 0.6 0.2 -0.6 0.5
Ever smoked 0.4 0.6 5.1 0.2 -0.7 -0.9 -2.2 0.7 0.0 1.0 -0.8 -0.7 -0.9 0.5 -0.5 -0.7 1.0 -0.2 -0.5 -0.9 -0.6 0.2 -0.7 0.1 -0.2 -0.5
Basal metabolic rate 0.2 1.1 10.3 0.6 0.1 0.3 3.2 -2.1 0.0 -0.6 0.2 -0.1 0.0 1.6 0.4 -0.4 0.3 -0.3 0.3 0.3 -1.2 -0.1 1.7 0.3 0.1 1.3
Leg fat percentage (left) 1.0 3.7 9.7 -2.4 -2.5 -2.0 -0.2 -1.9 0.0 -1.7 -2.1 -3.0 -2.0 -1.7 -3.0 0.7 -3.1 -0.1 -2.1 -2.1 0.4 -2.5 -0.5 -1.5 -2.1 0.3
Arm fat-free mass (left) 0.3 1.3 9.0 1.1 -0.4 -0.2 3.0 -2.5 0.0 -0.3 -0.3 -0.6 -0.6 1.9 -0.1 -0.4 0.3 -0.1 -0.2 -0.3 -1.5 -0.6 2.0 0.1 -0.0 1.7
Number of operations (self-reported) 1.7 2.5 8.8 -3.0 -2.1 -1.8 -1.8 -1.3 0.0 0.1 -1.8 -2.1 -0.9 -1.7 -2.2 0.2 -1.7 -0.8 -2.2 -2.0 0.1 -1.0 -1.8 -0.5 -1.7 -0.3
Average weekly beer plus cider intake 0.6 0.8 4.0 0.7 1.0 0.9 -0.4 1.8 0.0 -0.3 0.8 1.2 0.1 2.0 0.6 0.2 0.5 0.5 1.1 1.0 1.4 0.3 1.0 -0.1 0.7 -0.6
Irritability 1.0 1.8 7.5 -1.9 -1.4 -1.1 -0.6 -2.0 0.0 1.5 -1.2 -0.8 -0.4 0.8 0.2 -2.7 -0.8 -1.4 -0.7 -1.1 -1.9 -0.9 -0.8 1.2 -2.4 0.3
Risk taking 1.7 2.4 6.8 -2.6 -1.3 -1.2 -1.8 -1.6 0.0 0.9 -1.1 -1.0 -0.6 -1.5 -1.1 -2.5 -0.6 -2.5 -1.0 -1.1 -0.4 -1.3 -2.6 2.1 -1.3 -2.1
Ever had prostate specific antigen (PSA) test 1.4 1.7 4.5 -0.1 -1.9 -1.9 -1.7 -0.1 0.0 1.0 -1.9 -1.8 -1.2 -0.5 -1.4 2.1 0.2 -0.1 -2.0 -1.9 -1.4 -0.8 -0.7 -0.6 -1.2 0.5
Fractured/broken bones in last 5 years 0.8 1.0 7.7 0.6 1.1 0.7 -0.4 -0.2 0.0 0.6 0.9 0.5 1.0 0.2 1.2 -0.7 2.8 -0.1 1.2 0.6 0.5 1.9 0.7 0.0 1.3 -0.7
Age started oral contraceptive pill 0.8 1.0 4.4 -0.5 -1.1 -0.8 -0.3 -1.1 0.0 -0.3 -0.7 -0.7 -1.4 -0.5 -1.7 0.3 -2.0 0.4 -1.4 -0.9 0.4 -2.1 -0.6 -0.6 -1.2 -0.3
Diastolic blood pressure, automated reading 0.6 1.7 10.1 0.9 0.9 0.5 1.8 3.2 0.0 -1.3 0.6 0.2 1.4 -0.5 1.0 1.4 0.3 1.8 1.4 0.6 -0.4 1.6 1.4 -1.5 1.9 1.2
Ever depressed for a whole week 0.4 0.5 2.0 -1.1 -0.4 -0.5 -0.5 -0.7 0.0 1.0 -0.4 -0.5 -0.6 -0.9 -0.7 -1.4 0.6 -0.7 -0.5 -0.5 0.6 -0.0 -0.5 0.9 0.2 -0.7
Unable to work because of sickness or disability 0.3 0.4 1.7 -0.6 -0.8 -0.9 -0.5 0.3 0.0 0.9 -0.9 -1.3 -0.1 -0.6 -0.8 -0.7 0.5 -0.5 -0.1 -0.9 0.5 0.6 -0.1 -0.0 0.4 -0.2
Commuting to job workplace: Cycle 1.3 1.6 5.2 2.3 0.9 0.8 0.7 1.1 0.0 1.6 0.7 0.8 0.8 1.6 1.3 0.8 1.1 1.7 0.3 0.8 -0.4 1.1 2.2 -1.4 1.0 2.1
Myopia 0.5 0.7 4.3 -1.1 -0.9 -0.8 -2.1 -0.8 0.0 0.6 -0.8 -0.7 -0.6 -0.9 -0.5 -0.4 -1.0 -0.9 -0.8 -0.9 -0.0 -0.7 -0.2 0.3 -1.0 -0.3
Vascular/heart problems diagnosed by doctor 0.2 0.7 3.8 -1.3 0.2 0.5 -0.3 -0.6 0.0 -1.1 0.4 0.3 -0.6 0.8 -0.9 -1.7 0.1 -0.8 -0.4 0.4 2.0 -1.0 0.5 0.0 0.7 -0.1
Cholesterol lowering medication 0.3 0.4 1.1 0.7 -0.9 -0.8 -0.1 0.3 0.0 -0.6 -0.7 -1.0 -0.8 0.4 -1.1 0.1 -0.6 0.1 -0.6 -0.8 0.6 -0.8 0.3 0.5 0.6 0.5
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 2.4 0.0 -0.7 -0.6 0.8 -1.5 0.0 0.4 -0.7 -0.6 -1.2 1.2 0.2 -0.8 0.3 -0.6 -0.4 -0.7 -1.5 -1.0 -1.2 0.7 -1.5 -0.4
Pain experienced in last month 0.2 0.3 0.9 0.6 -0.2 -0.1 0.3 1.0 0.0 -0.6 -0.1 -0.1 -0.4 -0.6 -0.5 0.7 -0.7 0.8 -0.5 -0.1 0.2 -0.7 0.7 -0.6 0.1 0.5
Supplements: Calcium 1.8 1.9 4.8 -1.9 -1.6 -1.3 -1.8 -0.9 0.0 1.5 -1.4 -1.2 -1.6 -0.5 -1.3 0.1 -0.6 -1.1 -2.2 -1.3 -0.3 -1.6 -2.2 1.1 -2.1 -1.0
Basal cell carcinoma (self-reported) 0.2 0.3 1.3 -1.1 -0.2 -0.2 0.2 -1.1 0.0 0.6 -0.1 -0.4 -0.4 -0.2 0.3 0.0 0.2 -0.6 -0.2 -0.2 -0.3 -0.4 -0.9 1.0 -0.6 0.4
Heart attack/myocardial infarction (self-reported) 0.9 1.2 5.7 2.4 0.2 -0.1 1.5 1.3 0.0 1.3 -0.1 0.2 0.1 1.2 0.6 0.3 1.0 1.7 0.8 -0.0 -0.0 1.1 2.1 -0.6 1.1 1.4
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 3.0 -1.0 -0.6 -0.4 -0.6 -0.6 0.0 0.3 -0.4 -0.3 -0.1 -0.5 -0.7 -0.4 -0.5 -0.6 -0.5 -0.4 0.2 -0.1 -0.4 0.6 -0.6 -1.7
Heart disease (siblings) 0.6 0.7 1.8 1.1 -0.9 -1.1 -0.5 1.1 0.0 1.3 -1.0 -0.7 -1.0 1.2 -0.7 -0.3 -0.3 0.9 -0.4 -0.9 0.1 -0.7 1.3 -0.2 -0.1 0.8
Alcohol drinker status: Previous 0.9 1.0 2.5 -1.1 -1.4 -1.2 -1.6 -1.2 0.0 1.1 -1.4 -1.0 -0.8 0.8 -1.2 -1.1 -0.1 -0.8 -1.3 -1.2 -0.1 -0.9 -0.6 0.7 -0.8 -0.6
Pack years of smoking 0.8 1.1 3.7 0.3 -1.8 -1.9 -0.8 0.1 0.0 0.6 -1.9 -1.9 -0.9 -0.2 -1.1 -0.3 0.2 0.6 -1.1 -1.9 -0.8 0.1 0.1 -0.7 -1.1 1.1
Impedance of whole body 0.9 4.8 19.5 -2.0 -2.6 -2.6 -4.4 -0.4 0.0 1.2 -2.6 -2.2 -2.3 -3.0 -2.0 -0.1 -1.5 -0.7 -2.6 -2.6 -0.8 -2.8 -2.6 0.7 -2.7 -1.1
Leg fat mass (left) 0.6 2.2 5.2 -1.5 -2.0 -1.5 0.9 -2.3 0.0 -1.1 -1.7 -2.3 -1.9 -0.5 -2.3 0.3 -2.1 -0.2 -1.6 -1.7 -0.3 -2.1 -0.0 -0.8 -1.8 0.6
Arm predicted mass (left) 0.3 1.3 10.8 1.2 -0.1 0.1 3.3 -2.4 0.0 -0.4 0.0 -0.3 -0.4 1.8 0.2 -0.3 0.3 0.0 0.0 0.0 -1.5 -0.5 2.0 0.0 0.1 1.7