Best TWAS P=1.73e-66 · Best GWAS P=4.72e-125 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | METTL13 | 0.23 | 0.23 | bslmm | 479 | 0.27 | 2.0e-33 | 3.45 | 7.1 | 1.6e-12 | 0.04 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | PIGC | 0.11 | 0.01 | enet | 11 | 0.00 | 2.8e-01 | 9.47 | 8.8 | 1.4e-18 | 0.08 | 0.06 | 0.03 | TRUE |
| 3 | GTEx | Adrenal Gland | METTL18 | 0.36 | 0.33 | enet | 12 | 0.38 | 1.4e-14 | 4.91 | -5.2 | 2.0e-07 | 0.05 | 0.17 | 0.83 | FALSE |
| 4 | GTEx | Artery Coronary | METTL18 | 0.31 | 0.26 | lasso | 8 | 0.20 | 2.3e-07 | 5.51 | -5.3 | 1.2e-07 | 0.04 | 0.05 | 0.95 | FALSE |
| 5 | GTEx | Artery Tibial | PIGC | 0.11 | 0.00 | enet | 21 | 0.01 | 8.4e-02 | -2.28 | 17.2 | 1.7e-66 | 0.27 | 0.06 | 0.07 | TRUE |
| 6 | GTEx | Brain Caudate basal ganglia | DARS2 | 0.19 | 0.02 | lasso | 5 | 0.13 | 1.2e-04 | 5.11 | -5.5 | 4.0e-08 | 0.04 | 0.09 | 0.57 | TRUE |
| 7 | GTEx | Brain Cerebellum | METTL13 | 0.22 | 0.00 | enet | 25 | 0.05 | 1.5e-02 | 3.50 | -9.8 | 8.5e-23 | -0.30 | 0.09 | 0.43 | TRUE |
| 8 | GTEx | Brain Cerebellum | METTL18 | 0.31 | 0.36 | lasso | 7 | 0.34 | 8.4e-11 | 4.80 | -5.2 | 1.5e-07 | 0.05 | 0.04 | 0.96 | FALSE |
| 9 | GTEx | Breast Mammary Tissue (Male) | METTL18 | 0.30 | 0.14 | lasso | 6 | 0.18 | 6.6e-05 | 5.14 | -5.3 | 9.8e-08 | 0.04 | 0.07 | 0.90 | FALSE |
| 10 | GTEx | Breast Mammary Tissue (Female) | SUCO | 0.33 | 0.00 | lasso | 9 | 0.01 | 1.8e-01 | 5.16 | -7.5 | 8.0e-14 | -0.01 | 0.08 | 0.05 | TRUE |
| 11 | GTEx | Cells Transformed fibroblasts | PIGC | 0.12 | 0.00 | enet | 29 | 0.04 | 2.7e-04 | 20.94 | -11.3 | 1.4e-29 | -0.40 | 0.07 | 0.19 | TRUE |
| 12 | GTEx | Esophagus Gastroesophageal Junction | PIGC | 0.18 | 0.08 | enet | 12 | 0.13 | 1.7e-05 | 0.79 | 5.5 | 4.8e-08 | 0.01 | 0.21 | 0.04 | TRUE |
| 13 | GTEx | Esophagus Gastroesophageal Junction | METTL18 | 0.30 | 0.39 | lasso | 15 | 0.39 | 3.2e-15 | 4.80 | -5.3 | 1.4e-07 | 0.05 | 0.17 | 0.82 | FALSE |
| 14 | GTEx | Esophagus Muscularis | GORAB | 0.14 | 0.08 | lasso | 2 | 0.06 | 1.7e-04 | 5.34 | -5.4 | 6.8e-08 | -0.12 | 0.43 | 0.02 | FALSE |
| 15 | GTEx | Heart Left Ventricle | GORAB | 0.16 | 0.08 | enet | 22 | 0.03 | 6.9e-03 | 5.34 | -5.7 | 1.2e-08 | -0.11 | 0.24 | 0.05 | FALSE |
| 16 | GTEx | Lung | GORAB | 0.15 | 0.08 | enet | 23 | 0.10 | 6.2e-08 | 5.34 | -6.8 | 8.4e-12 | -0.07 | 0.80 | 0.01 | TRUE |
| 17 | GTEx | Muscle Skeletal | SUCO | 0.09 | 0.07 | lasso | 7 | 0.07 | 1.0e-07 | -7.07 | -7.0 | 3.7e-12 | -0.06 | 0.99 | 0.00 | TRUE |
| 18 | GTEx | Nerve Tibial | PIGC | 0.10 | 0.02 | enet | 10 | 0.02 | 1.3e-02 | -6.88 | 12.3 | 1.5e-34 | 0.21 | 0.16 | 0.04 | FALSE |
| 19 | GTEx | Nerve Tibial | METTL18 | 0.22 | 0.36 | lasso | 18 | 0.36 | 2.8e-26 | 4.91 | -5.1 | 3.0e-07 | 0.05 | 0.22 | 0.78 | FALSE |
| 20 | GTEx | Ovary | METTL18 | 0.34 | 0.25 | lasso | 18 | 0.24 | 1.3e-06 | 4.86 | -5.3 | 1.2e-07 | 0.06 | 0.08 | 0.90 | FALSE |
| 21 | GTEx | Pancreas | SUCO | 0.17 | 0.00 | enet | 15 | 0.07 | 5.6e-04 | 11.03 | -6.9 | 6.9e-12 | 0.04 | 0.12 | 0.06 | FALSE |
| 22 | GTEx | Pituitary | METTL18 | 0.19 | 0.05 | lasso | 6 | 0.10 | 2.2e-03 | 5.54 | -5.7 | 1.3e-08 | 0.07 | 0.04 | 0.93 | FALSE |
| 23 | GTEx | Prostate | METTL18 | 0.28 | 0.24 | lasso | 8 | 0.24 | 1.1e-06 | 5.51 | -5.5 | 3.3e-08 | 0.04 | 0.04 | 0.95 | FALSE |
| 24 | GTEx | Skin Sun Exposed Lower leg | GORAB | 0.07 | 0.01 | lasso | 5 | 0.00 | 4.2e-01 | -3.70 | -5.8 | 7.6e-09 | 0.09 | 0.09 | 0.10 | FALSE |
| 25 | GTEx | Skin Sun Exposed Lower leg | PIGC | 0.08 | 0.02 | lasso | 5 | 0.02 | 8.8e-03 | 11.14 | 11.3 | 1.6e-29 | -0.04 | 0.52 | 0.02 | FALSE |
| 26 | GTEx | Spleen | PIGC | 0.29 | 0.04 | lasso | 6 | 0.07 | 6.6e-03 | 7.02 | 13.3 | 3.4e-40 | 0.23 | 0.06 | 0.14 | FALSE |
| 27 | GTEx | Stomach | METTL18 | 0.25 | 0.30 | lasso | 6 | 0.33 | 2.4e-16 | 4.94 | -5.3 | 1.1e-07 | 0.05 | 0.22 | 0.78 | FALSE |
| 28 | GTEx | Testis | C1orf112 | 0.15 | 0.04 | lasso | 9 | 0.06 | 8.9e-04 | 4.94 | -5.4 | 5.9e-08 | 0.00 | 0.14 | 0.78 | FALSE |
| 29 | GTEx | Testis | METTL13 | 0.29 | 0.05 | lasso | 10 | 0.09 | 9.9e-05 | -8.49 | 15.5 | 5.4e-54 | 0.18 | 0.26 | 0.04 | FALSE |
| 30 | GTEx | Testis | SUCO | 0.17 | -0.01 | enet | 39 | 0.05 | 2.9e-03 | 8.42 | -5.5 | 3.2e-08 | -0.29 | 0.06 | 0.11 | FALSE |
| 31 | GTEx | Thyroid | SUCO | 0.09 | 0.08 | lasso | 1 | 0.07 | 8.9e-06 | 5.16 | -5.2 | 2.5e-07 | -0.01 | 0.93 | 0.00 | TRUE |
| 32 | GTEx | Thyroid | METTL18 | 0.19 | 0.31 | lasso | 16 | 0.32 | 3.3e-25 | 4.91 | -5.1 | 3.0e-07 | 0.04 | 0.20 | 0.79 | FALSE |
| 33 | GTEx | Vagina | METTL18 | 0.26 | 0.03 | enet | 46 | 0.12 | 8.9e-04 | 4.81 | -6.1 | 8.5e-10 | 0.04 | 0.07 | 0.78 | TRUE |
| 34 | GTEx | Whole Blood | PIGC | 0.19 | 0.10 | enet | 23 | 0.12 | 3.2e-11 | 11.38 | 10.9 | 8.7e-28 | 0.19 | 1.00 | 0.00 | TRUE |
| 35 | GTEx | Whole Blood | METTL18 | 0.08 | 0.06 | lasso | 7 | 0.05 | 1.1e-05 | 5.14 | -5.1 | 3.0e-07 | 0.03 | 0.13 | 0.87 | FALSE |
| 36 | NTR | Blood | VAMP4 | 0.01 | 0.01 | lasso | 4 | 0.01 | 3.8e-03 | -4.54 | -6.7 | 1.6e-11 | 0.00 | 0.36 | 0.05 | TRUE |
| 37 | YFS | Blood | METTL13 | 0.11 | 0.10 | bslmm | 482 | 0.10 | 1.5e-32 | 3.45 | -6.4 | 1.9e-10 | -0.05 | 1.00 | 0.00 | FALSE |
| 38 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PIGC | 0.05 | 0.00 | enet | 12 | 0.02 | 2.3e-04 | -6.74 | 5.8 | 4.8e-09 | -0.04 | 0.02 | 0.02 | FALSE |
| 39 | The Cancer Genome Atlas | Colon Adenocarcinoma | C1orf105 | 0.10 | 0.01 | blup | 100 | 0.04 | 1.8e-03 | 11.33 | 11.9 | 8.3e-33 | 0.23 | 0.01 | 0.88 | FALSE |
| 40 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PIGC | 0.10 | 0.01 | blup | 94 | 0.05 | 1.0e-06 | -6.88 | 9.7 | 2.7e-22 | -0.03 | 0.13 | 0.03 | TRUE |
| 41 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | METTL13 | 0.14 | 0.00 | blup | 89 | 0.03 | 8.0e-03 | 3.50 | -6.8 | 7.3e-12 | -0.07 | 0.02 | 0.06 | FALSE |
| 42 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ANKRD45 | 0.14 | 0.01 | lasso | 4 | 0.07 | 6.9e-08 | 4.73 | 5.5 | 5.1e-08 | -0.08 | 0.00 | 0.48 | FALSE |
| 43 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PIGC | 0.09 | 0.00 | blup | 94 | 0.04 | 2.9e-05 | -1.19 | 9.8 | 1.8e-22 | 0.05 | 0.04 | 0.53 | TRUE |
| 44 | The Cancer Genome Atlas | Lung Adenocarcinoma | PIGC | 0.04 | 0.00 | blup | 94 | 0.01 | 3.2e-02 | 2.29 | -5.3 | 1.4e-07 | -0.37 | 0.23 | 0.08 | TRUE |
| 45 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | GORAB | 0.15 | 0.07 | blup | 32 | 0.09 | 2.3e-04 | 5.20 | -5.2 | 1.9e-07 | -0.06 | 0.12 | 0.04 | FALSE |
| 46 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | PIGC | 0.16 | 0.06 | blup | 94 | 0.07 | 6.9e-04 | 5.34 | -7.3 | 3.2e-13 | 0.12 | 0.19 | 0.05 | FALSE |
| 47 | The Cancer Genome Atlas | Thyroid Carcinoma | DNM3 | 0.13 | 0.08 | enet | 29 | 0.10 | 4.9e-10 | -5.43 | -6.3 | 3.3e-10 | -0.18 | 1.00 | 0.00 | TRUE |
| 48 | The Cancer Genome Atlas | Thyroid Carcinoma | PIGC | 0.09 | 0.02 | blup | 94 | 0.05 | 5.2e-06 | -2.20 | 10.4 | 3.6e-25 | 0.07 | 0.18 | 0.13 | TRUE |
| 49 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | VAMP4 | 0.18 | 0.02 | blup | 85 | 0.05 | 1.9e-02 | -4.74 | -5.9 | 3.3e-09 | -0.02 | 0.08 | 0.12 | TRUE |