Best TWAS P=5.72e-17 · Best GWAS P=2.42e-23 conditioned to 8.88e-16
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | COG6 | 0.20 | 0.16 | lasso | 4 | 0.14 | 3.1e-11 | 7.1 | -7.0 | 2.1e-12 | 0.07 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | COG6 | 0.13 | 0.12 | enet | 13 | 0.13 | 2.9e-07 | 6.9 | -5.4 | 6.2e-08 | 0.06 | 0.38 | 0.60 | FALSE |
| 3 | GTEx | Artery Aorta | COG6 | 0.31 | 0.23 | enet | 15 | 0.28 | 9.4e-16 | 6.9 | -6.6 | 3.9e-11 | 0.07 | 0.99 | 0.01 | FALSE |
| 4 | GTEx | Artery Tibial | COG6 | 0.15 | 0.11 | lasso | 4 | 0.12 | 8.1e-10 | 7.0 | -6.5 | 7.3e-11 | 0.06 | 0.16 | 0.84 | FALSE |
| 5 | GTEx | Brain Cerebellar Hemisphere | DGKH | 0.26 | 0.01 | lasso | 4 | 0.10 | 1.9e-03 | -8.2 | -6.5 | 1.1e-10 | 0.00 | 0.01 | 0.92 | TRUE |
| 6 | GTEx | Brain Hippocampus | COG6 | 0.29 | 0.18 | lasso | 2 | 0.11 | 1.5e-03 | 6.9 | -7.2 | 6.8e-13 | 0.05 | 0.08 | 0.73 | FALSE |
| 7 | GTEx | Breast Mammary Tissue (Male) | CYCSP34 | 0.19 | 0.00 | lasso | 8 | -0.01 | 7.0e-01 | 3.3 | 5.5 | 5.1e-08 | -0.10 | 0.03 | 0.32 | FALSE |
| 8 | GTEx | Cells Transformed fibroblasts | COG6 | 0.44 | 0.41 | lasso | 3 | 0.40 | 1.2e-31 | 7.1 | -7.1 | 9.1e-13 | 0.06 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Esophagus Muscularis | COG6 | 0.21 | 0.19 | lasso | 3 | 0.19 | 1.6e-11 | 6.9 | -6.9 | 6.9e-12 | 0.06 | 0.97 | 0.03 | FALSE |
| 10 | GTEx | Heart Atrial Appendage | COG6 | 0.15 | 0.06 | lasso | 5 | 0.02 | 2.8e-02 | 6.9 | -6.2 | 5.5e-10 | 0.06 | 0.13 | 0.72 | TRUE |
| 11 | GTEx | Heart Left Ventricle | COG6 | 0.22 | 0.16 | lasso | 6 | 0.15 | 3.4e-08 | 7.2 | -6.8 | 9.0e-12 | 0.07 | 0.10 | 0.90 | FALSE |
| 12 | GTEx | Lung | WBP4 | 0.10 | 0.09 | lasso | 4 | 0.07 | 3.6e-06 | -6.5 | -6.2 | 5.7e-10 | 0.17 | 0.58 | 0.38 | TRUE |
| 13 | GTEx | Lung | COG6 | 0.10 | 0.04 | enet | 13 | 0.06 | 2.5e-05 | 7.1 | -7.1 | 1.5e-12 | 0.06 | 0.31 | 0.66 | FALSE |
| 14 | GTEx | Muscle Skeletal | WBP4 | 0.33 | 0.08 | lasso | 7 | 0.23 | 2.8e-22 | -4.2 | -5.4 | 5.8e-08 | 0.10 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Muscle Skeletal | COG6 | 0.41 | 0.40 | enet | 25 | 0.45 | 8.6e-49 | 7.1 | -6.9 | 6.5e-12 | 0.07 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Nerve Tibial | COG6 | 0.20 | 0.18 | lasso | 3 | 0.18 | 1.0e-12 | 7.1 | -7.1 | 1.2e-12 | 0.06 | 0.99 | 0.01 | FALSE |
| 17 | GTEx | Skin Sun Exposed Lower leg | WBP4 | 0.19 | 0.08 | lasso | 3 | 0.11 | 3.0e-09 | -6.5 | -5.4 | 6.9e-08 | 0.18 | 1.00 | 0.00 | FALSE |
| 18 | GTEx | Whole Blood | COG6 | 0.10 | 0.07 | lasso | 4 | 0.08 | 7.0e-08 | 7.1 | -8.4 | 5.7e-17 | 0.07 | 0.81 | 0.16 | TRUE |
| 19 | METSIM | Adipose | COG6 | 0.07 | 0.06 | enet | 8 | 0.06 | 8.1e-10 | 7.1 | -8.1 | 4.7e-16 | 0.07 | 0.87 | 0.13 | FALSE |
| 20 | YFS | Blood | COG6 | 0.07 | 0.08 | lasso | 5 | 0.08 | 1.6e-23 | -6.8 | -6.1 | 1.2e-09 | 0.02 | 1.00 | 0.00 | FALSE |
| 21 | YFS | Blood | KBTBD7 | 0.13 | 0.12 | lasso | 5 | 0.12 | 5.6e-36 | 5.7 | 5.6 | 1.8e-08 | -0.10 | 1.00 | 0.00 | TRUE |
| 22 | YFS | Blood | MRPS31 | 0.05 | 0.02 | blup | 387 | 0.03 | 6.5e-11 | -5.4 | 7.5 | 7.3e-14 | -0.04 | 0.16 | 0.84 | TRUE |
| 23 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SUGT1L1 | 0.10 | 0.00 | blup | 58 | 0.04 | 3.9e-04 | 3.8 | -6.6 | 3.9e-11 | 0.13 | 0.01 | 0.55 | FALSE |
| 24 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SUGT1L1 | 0.09 | 0.06 | lasso | 7 | 0.09 | 8.4e-18 | 3.3 | -6.9 | 3.8e-12 | 0.01 | 0.01 | 0.99 | FALSE |
| 25 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | COG6 | 0.17 | 0.09 | enet | 7 | 0.09 | 2.7e-05 | -6.8 | -5.9 | 4.0e-09 | 0.00 | 0.39 | 0.02 | FALSE |
| 26 | The Cancer Genome Atlas | Glioblastoma Multiforme | COG6 | 0.24 | 0.20 | lasso | 5 | 0.16 | 1.2e-05 | 6.9 | -7.2 | 8.3e-13 | 0.04 | 0.16 | 0.72 | FALSE |
| 27 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | COG6 | 0.04 | 0.03 | blup | 99 | 0.02 | 1.1e-03 | -7.0 | -8.1 | 5.1e-16 | 0.04 | 0.11 | 0.39 | FALSE |
| 28 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SUGT1L1 | 0.06 | 0.01 | blup | 58 | 0.03 | 1.9e-04 | -9.4 | -7.0 | 2.0e-12 | 0.11 | 0.00 | 0.98 | FALSE |
| 29 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | COG6 | 0.04 | 0.03 | blup | 99 | 0.03 | 1.9e-04 | -7.1 | -7.3 | 3.1e-13 | 0.07 | 0.54 | 0.22 | FALSE |
| 30 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | STOML3 | 0.03 | 0.01 | blup | 75 | 0.02 | 6.6e-03 | -6.2 | 5.8 | 5.4e-09 | 0.00 | 0.06 | 0.42 | FALSE |
| 31 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SUGT1L1 | 0.29 | 0.23 | lasso | 8 | 0.25 | 1.7e-28 | 3.3 | -6.4 | 1.2e-10 | -0.03 | 0.98 | 0.02 | FALSE |
| 32 | The Cancer Genome Atlas | Brain Lower Grade Glioma | COG6 | 0.13 | 0.15 | lasso | 14 | 0.19 | 1.1e-20 | 7.2 | -6.0 | 2.4e-09 | 0.07 | 0.82 | 0.18 | FALSE |
| 33 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SUGT1L1 | 0.32 | 0.22 | blup | 59 | 0.27 | 1.3e-30 | 3.3 | -5.9 | 3.8e-09 | 0.00 | 1.00 | 0.00 | FALSE |
| 34 | The Cancer Genome Atlas | Brain Lower Grade Glioma | WBP4 | 0.04 | 0.02 | blup | 23 | 0.04 | 1.2e-05 | 2.9 | -6.3 | 2.7e-10 | 0.02 | 0.04 | 0.60 | FALSE |
| 35 | The Cancer Genome Atlas | Lung Adenocarcinoma | SUGT1L1 | 0.12 | 0.02 | blup | 58 | 0.05 | 1.4e-06 | -5.4 | -5.2 | 2.0e-07 | -0.06 | 0.00 | 0.99 | FALSE |
| 36 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | COG6 | 0.03 | 0.02 | lasso | 4 | 0.01 | 4.0e-02 | -6.8 | -7.0 | 2.4e-12 | 0.04 | 0.12 | 0.13 | FALSE |
| 37 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SUGT1L1 | 0.09 | 0.03 | blup | 58 | 0.07 | 2.4e-05 | 2.3 | -5.6 | 2.2e-08 | -0.05 | 0.02 | 0.85 | FALSE |
| 38 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | SUGT1L1 | 0.34 | 0.15 | enet | 17 | 0.17 | 9.3e-08 | 3.3 | -5.2 | 1.5e-07 | -0.04 | 0.26 | 0.66 | FALSE |
| 39 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | SUGT1L1 | 0.22 | 0.07 | lasso | 11 | 0.13 | 9.4e-06 | -9.4 | -7.4 | 1.1e-13 | -0.01 | 0.01 | 0.96 | FALSE |
| 40 | The Cancer Genome Atlas | Prostate Adenocarcinoma | STOML3 | 0.03 | 0.01 | lasso | 3 | 0.02 | 6.6e-03 | -5.9 | 5.9 | 3.4e-09 | 0.01 | 0.04 | 0.53 | TRUE |
| 41 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SUGT1L1 | 0.21 | 0.11 | lasso | 9 | 0.16 | 5.7e-16 | 3.3 | -7.2 | 4.1e-13 | 0.02 | 0.02 | 0.98 | FALSE |
| 42 | The Cancer Genome Atlas | Stomach Adenocarcinoma | COG6 | 0.05 | 0.00 | blup | 99 | 0.02 | 8.2e-03 | -6.8 | -8.1 | 8.5e-16 | 0.07 | 0.04 | 0.12 | FALSE |
| 43 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SUGT1L1 | 0.09 | 0.06 | blup | 59 | 0.06 | 5.4e-05 | -9.4 | -7.1 | 1.7e-12 | -0.01 | 0.00 | 1.00 | FALSE |
| 44 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | SUGT1L1 | 0.17 | 0.02 | blup | 58 | 0.05 | 1.0e-02 | -3.6 | -5.5 | 3.3e-08 | 0.07 | 0.02 | 0.15 | FALSE |