Hub : Genes

DGKH

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellar Hemisphere 0.261 0.085 0.0015 0.014 NA 0.071 NA 0.096 0.140 NA 0.0071 NA 0.0019
2 GTEx Liver 0.333 0.107 0.0035 0.037 NA 0.038 NA 0.009 0.033 NA 0.0320 NA 0.1700
3 TCGA Pancreatic Adenocarcinoma 0.157 0.063 0.0039 0.026 0.043 0.015 NA 0.033 0.028 0.0066 0.0740 NA 0.0160

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.2 1.8 4.8 0.3 2.2 0.8
Bipolar Disorder or Schizophrenia 1.9 4.6 7.8 -2.8 1.3 2.0
Depressed Affect (Nagel 2018) 0.4 0.7 2.0 -1.4 -0.3 0.4
Depression (Nagel 2018) 0.5 0.7 1.9 0.1 -1.4 0.4
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.0 -0.4 1.0 -0.2
Neuroticism (Nagel 2018) 0.1 0.2 0.5 -0.7 -0.1 0.4
Schizophrenia (2018) 2.9 6.0 14.3 -3.8 -0.1 1.9
Schizophrenia vs Biploar Disorder 0.3 0.4 1.0 -1.0 -0.4 -0.2
Worry (Nagel 2018) 0.2 0.5 1.0 0.3 -1.0 -0.6
Alzheimer’s Disease (in mother) 0.1 0.1 0.3 0.4 0.5 -0.1
Alzheimer’s Disease (in father) 2.0 2.2 6.1 -2.5 -0.5 -0.5
Alzheimer’s Disease (including proxy) 0.4 0.6 1.6 -1.3 -0.2 -0.3
Crohns Disease (2017) 0.4 0.8 2.1 -0.2 -0.6 1.5
Irritable Bowel Disease (IBD) 0.5 1.1 3.3 0.2 -1.8 -0.1
Ulcerative Colitis (UC) 0.9 1.7 2.7 0.5 -1.4 -1.6
Major Depression (MDD) 0.7 0.9 2.3 0.4 -0.5 1.5
Reaction Time 1.6 3.1 7.5 -2.7 1.3 -0.2
Verbal and Numeric Reasoning (VNR) 0.2 0.4 0.7 -0.8 -0.4 -0.6
Breast Cancer 1.0 2.4 4.0 2.0 1.7 -0.4
Ovarian Cancer 0.6 0.8 2.2 -0.1 1.5 0.5
Prostate Cancer 1.2 1.7 2.8 -0.8 1.2 -1.7
Age at First Birth 1.1 1.6 4.4 2.1 0.1 0.5
Bipolar Disorder (2011) 0.4 0.4 0.9 -0.4 0.9 0.4
Body Mass Index (BMI) (2010) 0.5 0.7 1.9 -1.4 0.3 -0.3
Coronary Artery Disease (CAD) 0.2 0.3 0.4 -0.4 0.7 -0.4
Crohns Disease (2012) 0.9 1.5 4.1 -0.6 -0.2 2.0
Mean Putamen Volume 1.5 1.7 2.7 -1.1 -1.6 -1.2
Fasting Glucose 0.9 1.1 2.2 -0.9 -1.5 0.6
HbA1C 1.0 1.1 2.2 -1.5 0.8 -0.5
HDL Cholesterol 0.2 0.3 0.8 -0.9 -0.1 0.4
LDL Cholesterol 0.9 1.5 3.0 1.7 -0.5 1.0
Lupus 1.3 2.0 3.0 -1.6 1.7 0.4
Neuroticism (2016) 0.4 0.5 1.2 0.5 -1.1 -0.4
Primary Biliary Cirrhosis 1.2 1.7 3.3 -1.3 1.8 -0.5
Rheumatoid Arthritis 0.1 0.1 0.2 -0.1 0.4 0.3
Schizophrenia (2014) 2.3 5.2 13.8 -3.7 0.0 1.3
Triglycerides 0.6 1.0 2.3 0.9 -1.5 -0.0
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.8 -0.4 -0.1 -1.4
Ulcerative Colitis 0.3 0.5 1.1 0.1 -0.6 -1.1
Blood Eosinophil Count 0.3 2.3 6.8 -2.6 0.1 -0.2
Blood Platelet Count 0.1 0.9 1.9 -1.4 -0.9 -0.0
Blood Red Count 0.0 0.2 0.4 0.2 0.6 -0.4
Blood White Count 0.1 0.7 1.7 0.1 0.6 1.3
Heel T-Score 0.3 2.1 3.1 0.7 -1.8 -1.7
BMI 1.3 7.4 20.0 -4.5 -0.8 1.3
Height 1.0 19.7 41.6 -6.5 1.6 3.9
Waist Hip Ratio (WHR) 0.2 0.7 1.2 -0.1 -1.1 0.9
Systolic Blood Pressure 0.5 2.5 3.8 1.6 2.0 -1.0
Smoking Status 0.1 0.3 0.5 -0.6 -0.2 0.7
Allergy or Eczema 0.5 1.3 3.5 -0.5 -1.9 0.2
Cardiovascular Disease 0.0 0.1 0.1 0.2 0.3 0.1
Hypothyroidism (self reported) 1.2 2.8 8.2 -0.3 2.9 -0.4
Respiratory disease 0.1 0.1 0.2 -0.2 0.4 -0.5
Type 2 Diabetes (T2D) (2018) 0.5 0.8 1.9 1.4 0.1 0.8
Lung FEV1/FVC ratio 0.6 3.1 4.8 -0.9 -1.9 2.2
Lung FVC 0.2 1.1 3.1 -0.4 -0.1 -1.8
Neuroticism 0.3 0.7 2.0 -0.0 -1.4 -0.2
Chronotype (morning person) 0.7 1.6 2.0 1.2 -1.2 1.4
Hair Pigment 0.0 1.1 2.3 1.5 -0.1 -1.0
Tanning 0.0 0.3 0.7 0.2 -0.9 0.4
Hand grip strength (left) 2.0 5.2 15.0 -3.9 0.4 0.7
Number of treatments/medications taken 1.7 3.0 5.3 2.3 1.9 0.4
Average weekly spirits intake 0.3 0.4 0.7 -0.8 0.1 0.7
Sensitivity / hurt feelings 0.2 0.4 1.0 -0.1 0.5 1.0
Frequency of depressed mood in last 2 weeks 1.5 2.1 4.6 0.8 -2.1 1.0
Hearing difficulty/problems: Yes 0.2 0.2 0.3 0.3 0.5 -0.6
Relative age of first facial hair 1.1 2.2 5.5 2.3 -0.4 -0.9
Other serious medical condition/disability diagnosed by doctor 3.1 4.1 7.4 2.7 0.4 -2.1
Ever used hormone-replacement therapy (HRT) 1.0 1.3 2.0 1.4 0.6 -1.3
Ever had hysterectomy (womb removed) 3.4 3.9 6.9 2.6 0.4 2.1
Systolic blood pressure, automated reading 0.4 1.1 2.1 0.4 1.5 -0.9
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.3 -0.8 0.2 1.1
Angina 0.2 0.3 0.7 0.8 0.2 -0.5
Medication for hormone replacement therapy 0.7 0.8 2.4 0.0 -0.1 -1.6
Vitamin and mineral supplements 0.9 1.2 3.0 0.5 0.7 1.7
Supplements: Zinc 0.9 1.0 2.3 0.8 -0.3 -1.5
Medication: Co-codamol 1.7 1.9 3.8 -0.5 -1.9 1.3
Medication: Metformin 1.8 2.5 6.2 2.5 -0.4 1.0
Diabetes (father) 2.2 2.7 4.1 0.4 -2.0 -2.0
Diabetes (mother) 0.6 0.7 1.1 1.0 -1.0 0.3
Severe depression (siblings) 0.9 1.1 2.6 -1.6 -0.4 -0.7
Pack years adult smoking proportion 1.3 2.0 3.4 -1.2 1.8 1.1
Impedance of leg (right) 0.5 2.4 5.1 1.4 0.5 -2.3
Leg fat-free mass (left) 1.6 8.4 17.5 -4.2 1.1 2.5
Trunk fat percentage 1.3 5.1 14.4 -3.8 0.7 -0.7
Hand grip strength (right) 1.9 5.0 13.0 -3.6 0.6 1.3
Townsend deprivation index at recruitment 0.8 1.1 1.9 1.2 1.4 -0.2
Current tobacco smoking 0.7 1.1 1.6 -0.7 1.2 1.1
Average weekly fortified wine intake 0.7 0.9 2.4 0.4 -1.5 0.3
Maternal smoking around birth 0.2 0.3 0.7 -0.4 -0.8 -0.2
Fed-up feelings 0.0 0.0 0.1 -0.0 -0.3 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.7 0.9 -0.0 0.7
Relative age voice broke 1.1 1.7 3.2 1.2 -1.8 0.7
Taking other prescription medications 1.4 2.1 3.8 1.9 1.6 0.3
Age when periods started (menarche) 0.8 1.9 3.0 -1.7 1.1 1.2
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 1.4 0.6 1.2 0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 2.7 -0.0 1.6 0.7
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.3 -0.8 -1.1 -0.1
Qualifications: CSEs or equivalent 1.3 1.8 2.7 1.6 -1.1 1.2
Serious illness, injury or assault to yourself 1.0 1.2 3.1 0.3 -0.7 -1.8
High blood pressure 0.1 0.1 0.2 0.5 0.1 0.5
Hayfever, allergic rhinitis or eczema 0.5 1.0 2.6 -0.7 -1.6 0.1
Multivitamins +/- minerals 1.8 2.2 3.6 -1.9 -0.9 -1.5
Stomach or abdominal pain in last month 1.4 1.8 4.8 -0.2 -0.7 2.2
Supplements: Glucosamine 0.1 0.2 0.3 0.5 0.2 -0.4
Diverticular disease/diverticulitis (self-reported) 1.4 1.6 2.3 0.7 -1.5 1.4
Medication: Atenolol 0.9 1.1 3.2 1.8 -0.0 -0.3
Medication: Levothyroxine sodium 2.6 4.3 8.9 1.0 3.0 -1.7
Sitting height 0.4 2.7 4.9 -0.8 1.6 2.2
Chronic bronchitis/emphysema (father) 0.2 0.2 0.6 0.2 -0.7 -0.4
High blood pressure (mother) 0.4 0.5 1.1 -1.0 0.7 0.3
Body mass index (BMI) 1.2 5.1 14.2 -3.8 -0.4 0.9
Impedance of leg (left) 0.4 2.0 4.2 1.4 -0.2 -2.1
Leg predicted mass (left) 1.6 8.7 18.0 -4.2 1.1 2.6
Trunk fat mass 1.6 7.1 20.7 -4.5 0.7 0.3
Waist circumference 1.0 3.7 8.8 -3.0 0.0 1.5
Number of incorrect matches in round 0.1 0.1 0.2 0.5 0.2 -0.3
Past tobacco smoking 0.1 0.2 0.6 -0.3 0.2 0.8
Alcohol usually taken with meals 1.7 2.8 3.3 1.8 1.8 -1.3
Nervous feelings 0.9 1.7 2.6 1.6 0.1 -1.5
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 0.5 0.7 -0.5 0.7
Hearing difficulty/problems with background noise 1.6 2.5 5.0 0.6 2.2 -1.5
Hair/balding pattern: Pattern 2 1.2 1.6 2.9 1.7 0.5 -1.2
Had menopause 0.7 0.9 1.7 -1.3 0.1 -1.0
Had other major operations 1.2 1.4 3.5 0.1 -0.9 -1.9
Forced vital capacity (FVC) 0.4 1.5 4.1 -2.0 -0.4 -0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 2.1 -1.5 1.3 -0.5
Ever unenthusiastic/disinterested for a whole week 1.8 2.2 6.2 -2.5 -0.4 0.6
Qualifications: None of the above 0.3 0.6 1.3 0.6 0.1 -1.1
Financial difficulties in last 2 years 0.9 1.2 1.8 -1.1 -0.7 1.4
Mouth/teeth dental problems 1.4 2.1 3.4 1.6 -0.4 1.8
Heart attack 0.0 0.0 0.1 0.1 -0.2 0.3
Allergy 0.5 1.2 2.7 0.9 1.6 0.5
Pain all over the body in last month 0.7 0.8 1.4 0.9 1.2 0.3
Diabetes (self-reported) 1.7 2.6 7.5 2.7 -0.1 0.5
Hayfever/allergic rhinitis (self-reported) 3.2 4.2 7.7 -2.8 -0.9 2.0
Medication: Ramipril 1.3 1.6 3.4 0.8 -1.8 -0.9
Medication: Simvastatin 0.8 1.2 2.2 1.5 0.6 -1.0
Fluid intelligence score 1.1 2.2 4.2 -1.6 -0.3 -2.1
Illnesses of siblings 1.4 2.0 5.3 -0.8 2.3 -0.1
Neuroticism score 0.1 0.3 0.6 0.4 -0.8 0.4
Weight 2.0 9.8 25.4 -5.0 0.6 1.9
Impedance of arm (right) 0.5 2.5 4.6 2.1 0.8 -1.5
Arm fat percentage (right) 0.9 3.4 10.3 -3.2 -0.1 0.2
Trunk fat-free mass 1.3 7.5 14.4 -3.8 0.3 2.8
Hip circumference 1.1 4.9 12.2 -3.5 1.3 0.8
Time employed in main current job 0.2 0.2 0.7 0.8 -0.1 -0.1
Alcohol intake versus 10 years previously 0.5 0.8 1.2 -0.5 -1.1 0.9
Father’s age at death 1.4 1.9 4.0 1.2 0.7 -2.0
Worrier / anxious feelings 0.9 1.7 3.5 1.1 -1.9 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.2 0.4 -0.2 0.4
Falls in the last year 2.0 2.8 6.1 2.5 -1.1 -1.0
Hair/balding pattern: Pattern 3 1.0 1.5 2.2 -0.7 -1.5 1.3
Number of live births 0.7 1.0 1.8 -0.1 1.2 1.3
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 2.5 -1.6 -1.2 0.0
Pulse rate 1.5 2.5 5.3 0.8 1.2 2.3
Happiness 1.3 1.5 3.9 -0.7 0.3 2.0
Noisy workplace 0.8 1.0 1.9 0.7 -0.9 1.4
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.4 -0.5 1.2 0.1
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 1.2 -0.6 -1.1 0.1
Mouth/teeth dental problems: Dentures 2.0 3.4 6.4 -2.5 0.8 -1.8
Asthma 0.3 0.7 1.5 -0.3 -0.6 -1.2
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.3 0.6 -0.8 0.7 0.0
Medication: Cholesterol lowering 0.2 0.3 0.4 0.5 -0.4 -0.6
Depression (self-reported) 0.4 0.4 0.8 0.3 0.9 -0.7
Medication: Lansoprazole 1.3 1.5 3.7 0.8 1.9 0.1
Prospective memory result 3.3 4.1 8.6 1.8 -2.9 0.5
Lung cancer (father) 0.8 0.9 2.7 0.2 -1.6 -0.1
Illnesses of mother 0.7 0.9 1.5 1.2 -1.0 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.9 5.0 -2.2 -0.1 0.8
Pulse wave Arterial Stiffness index 0.3 0.3 0.6 -0.8 0.7 -0.0
Impedance of arm (left) 0.7 3.0 4.1 2.0 1.0 -2.0
Arm fat mass (right) 1.6 6.7 19.0 -4.4 0.1 1.0
Trunk predicted mass 1.3 7.6 14.5 -3.8 0.1 2.9
Standing height 0.8 7.9 14.0 -3.7 1.9 2.5
Length of working week for main job 0.3 0.3 0.6 -0.2 -0.5 0.8
Exposure to tobacco smoke at home 2.4 2.7 8.0 -2.8 -0.1 -0.4
Breastfed as a baby 0.4 0.5 1.0 -0.5 -0.5 -1.0
Tense / ‘highly strung’ 0.1 0.2 0.4 0.6 0.4 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.8 3.7 -0.0 -1.9 1.4
Hair/balding pattern: Pattern 4 0.2 0.4 0.6 -0.8 -0.4 -0.6
Birth weight of first child 1.7 3.1 6.1 -1.2 -2.5 1.3
Peak expiratory flow (PEF) 0.3 0.7 1.0 -0.7 -0.7 -1.0
Pulse wave reflection index 0.5 0.7 1.2 -0.7 -0.6 -1.1
Ever highly irritable/argumentative for 2 days 0.7 0.8 2.1 -0.1 -0.5 1.5
Loud music exposure frequency 0.8 0.9 1.8 -0.0 -0.9 1.4
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 0.7 0.6 0.9 0.4
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.5 -1.2 -0.3 0.9
Blood clot in the leg (DVT) 0.5 0.7 0.9 -1.0 -0.9 -0.5
Medication: Paracetamol 0.3 0.5 0.9 0.7 -1.0 0.3
Headache pain in last month 2.7 4.6 7.1 2.3 -1.2 2.7
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 1.6 -1.3 1.1 -0.1
Glaucoma (self-reported) 0.3 0.3 1.0 1.0 0.1 0.1
Gout (self-reported) 0.1 0.2 0.2 -0.4 0.5 0.4
Hypothyroidism/myxoedema (self-reported) 1.1 2.2 5.6 0.9 2.4 -0.5
Medication: Amlodipine 0.8 1.1 1.8 1.3 0.7 -1.0
Medication: Ventolin 100micrograms inhaler 0.8 1.0 2.9 0.3 1.7 0.4
Birth weight 1.8 3.9 6.1 -2.2 0.8 2.5
Chronic bronchitis/emphysema (mother) 0.8 1.0 2.7 -0.4 -1.7 0.1
High blood pressure (siblings) 0.9 1.3 3.2 0.4 -1.8 0.7
Forced vital capacity (FVC), Best measure 0.7 2.6 7.5 -2.7 0.5 0.3
Body fat percentage 1.3 5.1 14.7 -3.8 0.6 -0.6
Leg fat percentage (right) 1.4 5.1 14.9 -3.9 0.1 -0.6
Arm fat-free mass (right) 1.5 7.9 19.2 -4.4 0.4 2.1
Exposure to tobacco smoke outside home 1.3 1.7 3.2 -1.8 0.1 1.4
Comparative body size at age 10 2.0 5.5 10.0 -3.2 -1.3 2.2
Number of full brothers 1.0 1.3 3.9 0.0 0.2 -2.0
Worry too long after embarrassment 1.1 1.9 3.8 1.2 1.9 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.8 -0.1 0.1 0.9
Wheeze or whistling in the chest in last year 0.2 0.4 1.1 -0.4 -0.1 -1.0
Number of children fathered 0.4 0.5 0.6 0.7 -0.6 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 3.2 -1.0 0.2 -1.8
Age at first live birth 0.7 1.2 3.5 1.9 -0.2 -0.5
Pulse wave peak to peak time 0.1 0.2 0.2 0.5 -0.4 0.2
Health satisfaction 0.4 0.5 1.0 1.0 -0.5 0.5
Shortness of breath walking on level ground 0.3 0.4 0.5 0.7 -0.3 0.7
Qualifications: College or University degree 0.1 0.4 0.9 1.0 0.2 0.5
Eye problems/disorders: None of the above 1.4 1.6 3.8 -1.9 -0.7 0.8
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.2 0.2 0.1 -0.4
Emphysema/chronic bronchitis 0.9 1.0 1.2 0.8 1.1 1.1
Medication for pain relief, constipation, heartburn 0.3 0.6 1.6 -1.2 0.2 0.3
Neck or shoulder pain in last month 0.6 0.9 1.8 0.8 -1.3 0.5
Medication: Blood pressure 0.7 1.2 2.8 1.7 -0.6 0.6
Angina (self-reported) 0.2 0.3 0.6 0.7 0.1 -0.6
Migraine (self-reported) 2.1 2.6 3.8 1.9 0.9 1.8
Medication: Ibuprofen 0.1 0.1 0.3 -0.6 0.2 -0.1
Medication: Allopurinol 0.2 0.3 0.4 0.1 -0.6 -0.6
Medication: Omeprazole 1.7 2.1 4.3 1.4 0.3 -2.1
Medication: Seretide 50 evohaler 0.8 0.9 1.9 1.4 0.8 -0.3
Mean time to correctly identify matches 1.3 2.6 5.1 -2.3 1.5 -0.5
Heart disease (mother) 1.5 1.8 3.6 -1.3 1.9 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 1.8 1.3 1.3 -0.9
Whole body fat mass 1.8 7.5 22.1 -4.7 0.6 0.4
Leg fat mass (right) 1.9 7.3 21.4 -4.6 0.3 0.6
Arm predicted mass (right) 1.6 7.9 19.3 -4.4 0.3 2.1
Pulse rate, automated reading 1.9 6.1 12.2 1.9 1.6 3.5
Alcohol intake frequency. 0.3 0.7 2.0 1.4 -0.1 0.0
Comparative height size at age 10 1.4 8.0 22.5 -4.7 0.9 0.7
Number of full sisters 0.1 0.1 0.2 0.2 -0.5 -0.1
Suffer from ‘nerves’ 0.4 0.7 1.6 0.3 -1.3 0.6
Overall health rating 1.0 2.1 3.7 1.9 -0.7 1.5
Chest pain or discomfort 0.9 1.3 2.9 1.7 -0.0 -1.1
Had major operations 0.6 0.7 1.2 0.8 1.1 -0.6
Age at last live birth 0.4 0.6 1.5 1.2 0.4 0.3
Family relationship satisfaction 0.4 0.5 1.0 -0.7 -1.0 0.4
Leg pain on walking 0.3 0.3 0.8 -0.3 -0.9 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 0.4 0.4 0.7 0.5
Commuting to job workplace: Car/motor vehicle 0.9 1.0 3.0 0.3 -0.1 -1.7
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.6 -0.2 -0.8 -0.5
Medication: Aspirin 0.1 0.2 0.3 0.3 -0.5 -0.5
Supplements: Vitamin C 0.8 0.9 1.7 -0.2 -1.3 -1.0
Knee pain experienced in last month 0.7 1.2 2.1 -0.7 -1.4 1.0
Hypertension (Self-reported) 0.2 0.4 1.0 0.6 -0.0 1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 0.9 -0.1 0.9 -0.0
Illnesses of father: Heart disease 2.3 3.2 6.8 0.7 1.5 -2.6
Illnesses of siblings: Diabetes 0.6 0.7 1.6 0.7 0.1 -1.3
Smoking status: Previous 0.3 0.4 0.5 0.7 -0.6 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 1.4 2.8 5.3 -1.5 0.9 2.3
Whole body fat-free mass 1.5 8.4 17.2 -4.2 0.5 2.8
Leg fat-free mass (right) 1.5 8.1 15.5 -3.9 0.8 2.8
Arm fat percentage (left) 0.9 3.7 11.0 -3.3 -0.1 -0.1
Average weekly red wine intake 0.2 0.3 0.5 -0.2 0.7 -0.6
Handedness (chirality/laterality): Left-handed 1.5 1.8 4.4 2.1 -0.3 1.0
Mood swings 0.1 0.1 0.3 0.2 -0.1 0.6
Loneliness, isolation 0.5 0.7 1.0 -0.9 1.0 0.4
Long-standing illness, disability or infirmity 2.2 3.3 7.7 2.8 1.1 -1.0
Ever had bowel cancer screening 1.8 2.1 3.1 1.7 -1.8 0.1
Diabetes diagnosed by doctor 0.9 1.5 4.3 2.1 -0.2 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 1.4 0.3 -1.2 -1.0
Friendships satisfaction 0.1 0.1 0.2 -0.2 -0.2 -0.5
Qualifications: nursing, teaching 0.3 0.5 1.2 -0.5 1.1 -0.3
Commuting to job workplace: Walk 0.3 0.3 0.6 0.4 -0.7 -0.3
Eye problems/disorders: Cataract 1.3 1.5 3.1 0.9 1.8 -0.7
Mouth/teeth dental problems: Mouth ulcers 1.2 1.9 2.6 1.4 1.6 -1.1
Medication for cholesterol 0.5 0.7 1.6 -0.6 -0.5 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.1 2.5 4.5 -1.2 -2.1 1.3
Back pain experienced in last month 0.2 0.2 0.4 0.4 -0.7 0.3
Mineral and other dietary supplements 0.6 0.8 1.4 -1.2 -0.6 0.7
Breast cancer (self-reported) 0.1 0.2 0.3 0.3 -0.1 -0.6
Asthma (self-reported) 0.4 0.8 1.8 -0.2 -0.8 -1.3
Osteoporosis (self-reported) 0.3 0.4 0.9 1.0 0.2 0.5
Osteoarthritis (self-reported) 1.2 1.6 3.3 1.8 -0.3 1.1
Medication: Aspirin 0.1 0.1 0.3 -0.2 -0.5 -0.3
Medication: Gliclazide 0.5 0.5 0.8 0.8 -0.4 0.9
Illnesses of father: None of the above (group 1) 1.5 1.8 3.2 -1.4 -0.7 1.8
Smoking status: Current 0.5 0.8 1.0 -0.7 1.0 1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.4 -0.6 -0.4 -0.1
Whole body water mass 1.4 8.2 16.9 -4.1 0.6 2.7
Leg predicted mass (right) 1.4 7.7 14.9 -3.9 0.8 2.7
Arm fat mass (left) 1.5 6.2 18.0 -4.2 0.2 0.7
Number of self-reported non-cancer illnesses 0.4 0.7 1.5 0.8 0.3 1.2
Average weekly champagne plus white wine intake 1.4 2.0 4.7 0.7 2.2 -0.8
Miserableness 1.0 1.8 5.2 -0.4 -0.1 2.3
Guilty feelings 0.3 0.4 1.2 1.1 -0.2 0.2
Wears glasses or contact lenses 2.3 2.6 4.4 0.0 -1.8 -2.1
Ever taken oral contraceptive pill 2.2 2.4 5.3 -0.6 1.3 -2.3
Hearing aid user 1.7 1.9 3.9 1.1 2.0 -0.8
Mother’s age at death 0.1 0.1 0.2 0.4 0.0 -0.5
Financial situation satisfaction 0.8 1.0 2.4 -0.8 -0.4 1.5
Tinnitus: Yes, now most or all of the time 0.9 1.0 2.8 0.5 0.3 -1.7
Commuting to job workplace: Public transport 1.4 1.6 3.0 -1.7 1.0 0.9
Eye problems/disorders: Glaucoma 0.6 0.7 1.5 1.2 -0.6 0.3
Medication: Blood pressure 0.2 0.4 0.6 -0.8 0.8 -0.2
Pain type(s) experienced in last month: Hip pain 0.9 1.1 2.6 1.6 -0.6 0.5
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.1 0.3 -0.1 0.3
High cholesterol (Self-reported) 0.3 0.5 1.0 1.0 -0.7 -0.3
Medication: Bendroflumethiazide 0.9 1.4 3.5 -0.8 -0.2 -1.9
Medication: Paracetamol 0.5 0.8 1.1 1.1 -0.7 0.8
Medication: Lisinopril 0.4 0.5 0.8 -0.3 0.7 0.9
Medication: Atorvastatin 0.4 0.5 1.3 0.4 0.4 1.1
Illnesses of father: High blood pressure 0.7 0.8 2.1 -0.5 -0.4 1.4
Alcohol drinker status: Never 4.2 5.1 10.4 3.2 -1.5 -1.6
Ever smoked 0.2 0.3 0.5 -0.5 0.7 -0.3
Basal metabolic rate 1.7 9.2 20.2 -4.5 0.8 2.6
Leg fat percentage (left) 1.4 5.2 15.3 -3.9 -0.3 -0.4
Arm fat-free mass (left) 1.7 8.6 18.4 -4.3 0.3 2.7
Number of operations (self-reported) 0.1 0.1 0.2 0.2 -0.4 0.2
Average weekly beer plus cider intake 1.5 2.1 4.9 -2.2 0.7 1.1
Irritability 0.6 1.0 2.7 -0.1 -0.6 -1.6
Risk taking 0.6 0.9 2.6 0.3 -0.0 1.6
Ever had prostate specific antigen (PSA) test 0.5 0.6 0.6 -0.8 -0.7 -0.8
Fractured/broken bones in last 5 years 1.2 1.5 3.3 1.8 -0.5 -1.0
Age started oral contraceptive pill 0.4 0.5 0.8 0.7 0.9 -0.4
Diastolic blood pressure, automated reading 0.1 0.3 0.8 -0.1 0.9 -0.0
Ever depressed for a whole week 0.5 0.7 1.2 -0.3 -0.8 -1.1
Unable to work because of sickness or disability 0.7 0.9 1.6 1.2 -0.9 -0.4
Commuting to job workplace: Cycle 0.5 0.6 1.2 0.0 -0.8 1.1
Myopia 0.1 0.2 0.2 -0.4 -0.5 -0.3
Vascular/heart problems diagnosed by doctor 0.1 0.4 0.9 -0.9 -0.4 -0.4
Cholesterol lowering medication 0.6 0.9 1.5 1.2 0.3 -1.1
Medication: Omeprazole (e.g. Zanprol) 1.4 1.7 4.5 0.6 0.5 -2.1
Pain experienced in last month 1.6 2.7 5.5 -1.4 0.8 -2.3
Supplements: Calcium 0.1 0.1 0.2 0.3 -0.3 -0.4
Basal cell carcinoma (self-reported) 1.8 2.1 3.6 -1.0 -1.9 -1.3
Heart attack/myocardial infarction (self-reported) 0.0 0.0 0.1 0.3 -0.0 0.2
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 1.4 -1.2 -1.1 -0.1
Heart disease (siblings) 0.1 0.1 0.2 0.4 -0.0 -0.3
Alcohol drinker status: Previous 0.8 0.9 2.4 0.6 1.5 -0.2
Pack years of smoking 0.9 1.4 2.6 -0.9 1.6 0.9
Impedance of whole body 0.7 3.7 6.4 2.0 0.9 -2.5
Leg fat mass (left) 2.0 7.8 22.6 -4.8 0.2 0.8
Arm predicted mass (left) 1.7 8.7 19.4 -4.4 0.4 2.6