TWAS hub - STOML3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Clear Cell Carcinoma	0.0321	0.0166	0.0023	0.006	0.015	0.015	NA	0.010	0.07	0.0066	0.0074	NA	0.0240
2	TCGA	Lung Squamous Cell Carcinoma	0.0490	0.0266	0.0089	-0.002	0.009	0.001	NA	-0.002	0.65	0.0270	0.2400	NA	0.8100
3	TCGA	Prostate Adenocarcinoma	0.0343	0.0203	0.0086	0.011	0.006	0.010	NA	0.017	0.02	0.0620	0.0270	NA	0.0066

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Severe depression (siblings)	6.0	6.7	9.0	-2.1	-2.6	-3.0
Angina (self-reported)	5.8	7.6	10.5	-3.2	-2.9	-2.0
Angina	5.7	7.5	9.3	-3.0	-3.0	-2.1
Number of live births	5.6	8.0	9.6	2.7	2.7	3.1
Heart attack/myocardial infarction (self-reported)	4.8	6.1	8.4	-2.9	-1.7	-2.7
Hayfever/allergic rhinitis (self-reported)	4.4	5.8	6.6	2.3	2.4	2.6
Heart attack	3.7	4.7	7.0	-2.6	-1.2	-2.4
Medication: Atenolol	3.6	4.5	11.0	-1.3	-3.3	-0.9
Qualifications: CSEs or equivalent	3.5	4.6	8.1	2.8	1.5	1.9
Forced expiratory volume in 1-second (FEV1), predicted	3.3	6.9	12.4	3.5	-0.5	2.8
Father’s age at death	3.1	4.2	8.2	1.1	2.9	1.8
Number of children fathered	3.1	3.4	5.8	2.1	-0.1	2.4
Medication: Ramipril	3.0	3.9	6.6	-2.6	-0.2	-2.3
Schizophrenia vs Biploar Disorder	2.9	3.8	5.6	1.7	1.7	2.4
Health satisfaction	2.9	3.8	5.4	-1.5	-2.3	-1.9
Heart disease (mother)	2.9	3.6	5.6	-1.7	-1.5	-2.4
Happiness	2.8	3.4	5.5	-1.9	-1.1	-2.4
Type 2 Diabetes (T2D) (2012)	2.7	3.2	4.1	2.0	1.4	1.8
Medication: Aspirin	2.7	3.6	6.9	-2.6	-0.3	-2.0
Comparative height size at age 10	2.6	14.3	22.2	4.4	1.2	4.7
Mother’s age at death	2.5	3.1	4.0	-1.9	-1.3	-2.0
Standing height	2.4	24.3	33.8	5.8	2.4	5.8
Exposure to tobacco smoke outside home	2.4	3.2	5.0	-1.3	-1.7	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.6	3.8	1.9	1.1	1.7
Ever used hormone-replacement therapy (HRT)	2.3	2.9	3.9	-1.6	-2.0	-1.6
Forced vital capacity (FVC), Best measure	2.3	8.3	12.7	3.6	1.5	3.2
Deep venous thrombosis (DVT) (self-reported)	2.3	2.9	4.2	2.1	1.3	1.7
Bipolar Disorder (2011)	2.2	2.1	4.7	-0.8	-2.2	-1.0
Rheumatoid Arthritis	2.2	3.0	4.8	-1.3	-2.2	-1.6
Hearing difficulty/problems with background noise	2.2	3.5	5.0	-2.1	-1.0	-2.2
Medication for cholesterol, blood pressure or diabetes	2.2	3.6	6.8	1.1	1.7	2.6
Neck or shoulder pain in last month	2.2	3.2	5.6	-1.6	-2.4	-1.2
Hearing difficulty/problems: Yes	2.1	3.2	4.3	-2.1	-1.5	-1.8
Forced vital capacity (FVC)	2.1	8.2	11.0	3.3	1.8	3.2
Number of full sisters	2.1	2.6	3.8	-0.9	-1.8	-2.0
Chest pain or discomfort	2.1	3.0	4.7	-0.9	-2.2	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.5	3.6	-1.7	-0.9	-1.9
Townsend deprivation index at recruitment	2.0	2.8	3.9	-2.0	1.6	-1.3
Illnesses of mother	2.0	2.5	3.4	1.3	1.5	1.9
Headache pain in last month	2.0	3.4	6.5	-2.6	-1.0	-1.6
Pain type(s) experienced in last month: Hip pain	2.0	2.6	4.4	0.8	2.1	1.6
Average weekly red wine intake	1.9	2.8	4.0	1.5	1.5	2.0
Medication: Aspirin	1.9	2.5	5.0	-2.2	0.1	-1.5
Illnesses of siblings	1.8	2.6	3.9	1.0	1.7	2.0
Lung cancer (father)	1.8	2.1	3.1	-1.8	-0.9	-1.6
Pulse wave reflection index	1.8	2.2	3.0	-1.1	-1.7	-1.5
Back pain experienced in last month	1.8	2.6	5.9	-0.8	-2.4	-1.1
Supplements: Fish oil (including cod liver oil)	1.8	2.3	3.3	1.8	0.8	1.8
Ever had prostate specific antigen (PSA) test	1.8	2.1	3.0	-1.7	-1.5	-1.1
Bipolar Disorder (2018)	1.7	2.7	3.3	-1.6	-1.8	-1.5
Lung FEV1/FVC ratio	1.7	8.7	18.0	-1.3	-4.2	-2.5
Loud music exposure frequency	1.7	1.8	2.3	-1.2	-1.5	-1.4
Smoking status: Previous	1.7	2.5	4.6	-2.1	0.4	-1.6
Wears glasses or contact lenses	1.7	1.9	4.3	0.1	1.2	2.1
Pain experienced in last month	1.7	2.9	5.3	1.6	2.3	0.9
Alcohol drinker status: Previous	1.7	1.9	2.5	1.6	0.8	1.6
Major Depression (MDD)	1.6	1.9	2.3	-1.5	-1.5	-1.1
Diabetes (father)	1.6	2.0	2.5	1.3	1.6	1.3
Past tobacco smoking	1.6	2.9	5.6	2.4	0.0	1.8
Ever smoked	1.6	2.8	5.3	-2.3	-0.8	-1.6
Systolic blood pressure, automated reading	1.5	4.3	6.6	2.6	1.7	1.9
Stomach or abdominal pain in last month	1.5	1.8	2.4	-1.6	-1.3	-1.1
Supplements: Glucosamine	1.5	1.9	3.9	2.0	0.5	1.3
Blood clot in the leg (DVT)	1.5	1.9	2.8	1.7	1.2	1.2
Height	1.4	26.8	34.9	5.8	3.4	5.9
Medication: Co-codamol	1.4	1.7	3.7	-1.9	-0.3	-1.1
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	3.4	-1.2	-1.8	-1.4
Depression (self-reported)	1.4	1.7	4.5	0.7	0.4	2.1
Birth weight of first child	1.4	2.5	4.2	1.2	2.1	1.4
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	1.8	-1.4	-1.3	-1.2
Fractured/broken bones in last 5 years	1.4	1.7	2.8	1.4	-0.6	1.7
Primary Biliary Cirrhosis	1.3	1.9	4.2	-1.2	2.1	-0.3
Sitting height	1.3	9.5	15.0	3.9	1.8	3.2
Age at first live birth	1.3	2.3	3.9	2.0	0.8	1.5
Overall health rating	1.3	2.8	4.3	-1.4	-2.1	-1.5
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	3.1	-1.8	-1.6	-0.5
Heart disease (siblings)	1.3	1.6	3.0	-0.3	-1.3	-1.7
Chronic bronchitis/emphysema (father)	1.2	1.4	4.2	0.3	-2.0	-0.1
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	1.9	-1.4	-1.1	-1.2
Worrier / anxious feelings	1.2	2.3	4.4	-1.2	-1.1	-2.1
Prospective memory result	1.2	1.5	4.3	-2.1	0.3	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.8	8.2	2.9	-0.3	1.8
Shortness of breath walking on level ground	1.2	1.4	4.1	0.2	2.0	-0.1
Medication: Omeprazole	1.2	1.5	2.5	-0.6	-1.6	-1.2
Average weekly fortified wine intake	1.1	1.3	2.0	1.4	0.3	1.4
Hip circumference	1.1	4.9	9.2	3.0	0.4	2.3
Medication: Amlodipine	1.1	1.5	3.6	-0.9	0.2	-1.9
Medication: Blood pressure	1.1	1.9	4.4	-0.8	-0.8	-2.1
Mineral and other dietary supplements	1.1	1.4	3.2	-1.8	-0.3	-1.0
Hearing aid user	1.1	1.2	1.8	-0.4	-1.3	-1.3
Diabetes (mother)	1.0	1.3	3.2	-0.4	-1.8	-0.7
High blood pressure (mother)	1.0	1.4	2.2	-0.7	-1.2	-1.5
Number of incorrect matches in round	1.0	1.7	2.1	-1.3	-1.1	-1.4
Medication: Simvastatin	1.0	1.4	2.1	-1.3	0.6	-1.4
Weight	1.0	5.0	9.9	3.2	0.3	2.2
Forced expiratory volume in 1-second (FEV1)	1.0	3.5	6.8	2.6	-0.4	1.9
Breastfed as a baby	1.0	1.3	2.9	0.5	1.7	0.8
Family relationship satisfaction	1.0	1.3	3.6	0.5	1.9	0.1
Mood swings	1.0	1.8	2.5	1.6	1.6	0.8
Medication: Lisinopril	1.0	1.3	3.4	1.9	0.6	-0.1
Basal metabolic rate	1.0	5.5	10.8	3.3	0.1	2.4
Basal cell carcinoma (self-reported)	1.0	1.2	2.3	-1.5	-0.8	-0.7
Cardiovascular Disease	0.9	2.8	4.4	-0.3	-2.1	-2.0
Maternal smoking around birth	0.9	1.4	3.5	0.8	-1.9	0.3
Serious illness, injury or assault to yourself	0.9	1.0	2.7	-0.6	-1.6	0.2
Leg predicted mass (left)	0.9	4.7	9.1	3.0	-0.4	2.2
Trunk fat mass	0.9	3.8	6.9	2.6	0.7	2.0
Trunk fat-free mass	0.9	5.4	10.2	3.2	0.3	2.4
Hair/balding pattern: Pattern 3	0.9	1.3	3.9	-0.1	2.0	0.3
Pulse rate	0.9	1.6	4.5	-0.1	2.1	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.4	-0.5	-0.8	-1.5
Medication: Cholesterol lowering	0.9	1.3	2.2	-1.1	-0.7	-1.5
Trunk predicted mass	0.9	5.2	9.9	3.1	0.2	2.4
Peak expiratory flow (PEF)	0.9	2.0	3.7	1.9	-0.5	1.5
Birth weight	0.9	1.9	4.1	-1.2	-2.0	-0.5
Medication for pain relief, constipation, heartburn	0.9	1.6	2.8	0.9	1.1	1.7
Illnesses of father: Heart disease	0.9	1.3	1.5	-1.0	-1.2	-1.2
Whole body fat-free mass	0.9	4.9	9.4	3.1	-0.1	2.3
Leg fat-free mass (right)	0.9	4.6	8.8	3.0	-0.3	2.2
Breast cancer (self-reported)	0.9	1.0	1.6	1.1	0.5	1.3
Whole body water mass	0.9	5.2	9.9	3.1	-0.0	2.4
Unable to work because of sickness or disability	0.9	1.2	2.2	-1.5	-0.6	-1.0
HbA1C	0.8	0.9	1.5	0.0	1.1	1.2
Lupus	0.8	1.2	3.2	0.3	1.8	0.5
Number of treatments/medications taken	0.8	1.5	3.7	-0.9	-0.2	-1.9
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.3	-1.0	0.1	-1.5
Leg fat-free mass (left)	0.8	4.4	8.6	2.9	-0.5	2.1
Had other major operations	0.8	1.0	1.8	1.3	0.2	1.1
Pain all over the body in last month	0.8	0.9	1.4	0.7	0.9	1.2
Time employed in main current job	0.8	0.9	1.5	-1.1	1.2	-0.4
Impedance of arm (left)	0.8	3.7	4.8	1.6	2.0	2.2
Medication: Seretide 50 evohaler	0.8	0.9	1.6	1.2	0.6	0.9
Leg predicted mass (right)	0.8	4.3	8.3	2.9	-0.4	2.1
Ever taken oral contraceptive pill	0.8	0.9	1.6	-0.3	-1.0	-1.3
Ever depressed for a whole week	0.8	1.0	2.0	-0.3	-0.9	-1.4
Commuting to job workplace: Cycle	0.8	0.9	2.5	0.4	-1.6	0.3
Arm predicted mass (left)	0.8	4.0	8.6	2.9	0.3	1.8
Bipolar Disorder or Schizophrenia	0.7	1.6	1.9	-1.0	-1.3	-1.4
Intelligence (Savage-Jansen 2018)	0.7	2.0	4.1	1.2	0.7	2.0
Ulcerative Colitis (UC)	0.7	1.3	2.7	1.0	1.7	0.5
Ulcerative Colitis	0.7	1.0	1.5	1.2	0.0	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.5	-0.2	-1.6	-0.5
Arm fat-free mass (right)	0.7	3.8	8.8	3.0	0.0	1.6
Medication: Allopurinol	0.7	1.0	1.8	-1.0	0.4	-1.4
Arm predicted mass (right)	0.7	3.3	7.4	2.7	-0.1	1.6
Knee pain experienced in last month	0.7	1.0	2.1	-0.4	-1.5	-0.9
Medication: Gliclazide	0.7	0.8	2.0	-0.1	1.4	-0.5
Illnesses of father: High blood pressure	0.7	0.9	2.0	1.4	-0.3	0.7
Arm fat-free mass (left)	0.7	3.6	8.1	2.9	0.0	1.7
Vascular/heart problems diagnosed by doctor	0.7	2.0	4.5	1.0	0.7	2.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.0	-0.5	-1.4	-0.7
Irritable Bowel Disease (IBD)	0.6	1.3	2.9	1.7	0.9	0.5
HDL Cholesterol	0.6	0.9	1.8	1.4	0.6	0.8
Neuroticism	0.6	1.4	2.2	-1.3	-0.4	-1.5
Ever had hysterectomy (womb removed)	0.6	0.6	1.3	-0.7	-1.1	-0.2
Impedance of leg (right)	0.6	2.8	4.8	1.1	2.2	1.6
Trunk fat percentage	0.6	2.3	3.9	2.0	0.7	1.5
Relative age voice broke	0.6	0.9	1.2	0.6	1.1	1.1
Age when periods started (menarche)	0.6	1.5	2.2	-1.1	-1.5	-1.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	2.1	0.4	1.4	0.1
Impedance of leg (left)	0.6	3.0	5.0	1.2	2.2	1.6
Nervous feelings	0.6	1.1	2.2	1.0	1.5	0.3
Exposure to tobacco smoke at home	0.6	0.7	1.4	1.2	0.4	0.8
Worry too long after embarrassment	0.6	1.1	2.6	-0.1	-1.6	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.3	0.3	0.9	1.1
Whole body fat mass	0.6	2.7	5.0	2.2	0.5	1.7
Pulse rate, automated reading	0.6	2.0	4.9	-0.8	2.2	-0.6
Long-standing illness, disability or infirmity	0.6	1.0	2.4	-0.3	-1.6	-0.6
Ever had bowel cancer screening	0.6	0.7	1.3	-0.7	0.6	1.1
Commuting to job workplace: Public transport	0.6	0.7	1.0	1.0	0.9	0.4
Medication: Bendroflumethiazide	0.6	0.9	2.0	0.5	1.4	0.5
Medication: Paracetamol	0.6	0.9	2.0	-0.7	-0.4	-1.4
Irritability	0.6	1.0	2.3	-0.1	1.5	0.9
Risk taking	0.6	1.0	1.2	-0.8	-1.1	-1.0
Myopia	0.6	0.9	2.5	0.6	0.1	1.6
Depression (Nagel 2018)	0.5	0.8	1.7	-0.7	-1.3	-0.3
Relative age of first facial hair	0.5	1.0	2.3	0.3	1.5	0.8
Medication for hormone replacement therapy	0.5	0.6	1.1	1.1	-0.4	0.7
Waist circumference	0.5	2.0	4.4	2.1	0.1	1.2
Qualifications: None of the above	0.5	1.0	1.4	-0.9	-0.8	-1.2
Impedance of arm (right)	0.5	2.5	4.3	1.0	1.5	2.1
Arm fat mass (right)	0.5	1.9	3.6	1.9	-0.0	1.4
Comparative body size at age 10	0.5	1.4	2.0	0.6	1.3	1.4
Eye problems/disorders: None of the above	0.5	0.6	1.3	0.2	-1.1	-0.6
Emphysema/chronic bronchitis	0.5	0.6	0.9	0.4	-1.0	0.9
Age at last live birth	0.5	0.8	1.3	1.1	0.9	0.4
Leg pain on walking	0.5	0.6	1.4	-0.4	1.2	0.5
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.2	0.8	0.2	1.1
Supplements: Vitamin C	0.5	0.6	1.7	0.3	1.3	0.2
Illnesses of father: None of the above (group 1)	0.5	0.6	1.4	-0.6	1.2	0.4
Arm fat mass (left)	0.5	2.2	4.4	2.1	0.3	1.4
Diastolic blood pressure, automated reading	0.5	1.4	3.3	1.8	1.0	-0.1
Impedance of whole body	0.5	2.5	3.9	1.2	2.0	1.5
Leg fat mass (left)	0.5	1.9	4.6	2.2	-0.1	1.1
Alzheimer’s Disease (in father)	0.4	0.5	0.8	0.2	0.9	0.8
Crohns Disease (2017)	0.4	0.8	2.1	1.4	0.6	0.1
Neuroticism (2016)	0.4	0.5	1.0	0.1	1.0	0.8
Systolic Blood Pressure	0.4	2.0	2.6	1.5	1.1	1.6
Hypothyroidism (self reported)	0.4	0.8	1.7	0.8	-0.1	1.3
Average weekly spirits intake	0.4	0.4	0.8	0.9	0.4	0.6
Current tobacco smoking	0.4	0.7	1.4	0.9	0.1	1.2
Alcohol intake versus 10 years previously	0.4	0.5	0.6	-0.7	-0.7	-0.8
Noisy workplace	0.4	0.5	1.2	-0.7	1.1	-0.1
Medication: Lansoprazole	0.4	0.5	0.6	-0.6	-0.7	-0.8
Pulse wave Arterial Stiffness index	0.4	0.5	1.0	0.3	1.0	0.7
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.1	0.5	-0.0	1.5
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.1	-1.1	0.4	-0.4
Number of full brothers	0.4	0.5	1.2	-0.1	-0.6	-1.1
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.0	0.3	0.6	1.0
Migraine (self-reported)	0.4	0.5	0.9	-0.9	0.2	-0.8
Leg fat mass (right)	0.4	1.6	3.8	2.0	-0.1	1.0
Suffer from ‘nerves’	0.4	0.6	0.7	0.6	0.8	0.8
Had major operations	0.4	0.5	0.9	-1.0	0.7	-0.4
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.2	1.1	0.5	0.3
Eye problems/disorders: Cataract	0.4	0.4	0.7	0.1	0.8	0.8
Average weekly beer plus cider intake	0.4	0.6	1.8	1.3	0.2	0.2
Breast Cancer	0.3	0.6	1.2	0.4	0.8	1.1
Ovarian Cancer	0.3	0.4	0.7	0.6	0.9	0.3
Prostate Cancer	0.3	0.4	0.7	-0.6	0.5	-0.8
Age at First Birth	0.3	0.5	0.8	0.9	-0.5	0.7
Fasting Glucose	0.3	0.4	0.6	-0.2	-0.7	-0.8
Heel T-Score	0.3	2.3	3.9	-1.7	-0.3	-2.0
Chronotype (morning person)	0.3	0.6	1.1	-0.9	1.0	-0.2
Supplements: Zinc	0.3	0.3	0.7	0.8	0.4	0.2
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.6	0.3	1.3	0.3
Medication: Levothyroxine sodium	0.3	0.6	1.6	-0.1	0.3	1.3
Mouth/teeth dental problems	0.3	0.4	1.1	-0.1	-1.0	-0.3
Falls in the last year	0.3	0.4	0.6	-0.5	-0.5	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.7	0.4	0.8	0.5
Length of working week for main job	0.3	0.3	1.0	-1.0	-0.3	-0.1
Tense / ‘highly strung’	0.3	0.6	1.2	0.7	-0.0	1.1
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.6	-0.8	0.4	-0.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.9	0.3	1.0	0.6
Gout (self-reported)	0.3	0.4	0.9	-0.1	0.4	-1.0
Body fat percentage	0.3	1.3	2.6	1.6	0.4	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.6	-0.8	-0.0	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.1	0.0	-0.2	-1.0
Loneliness, isolation	0.3	0.4	0.9	0.0	-0.6	-0.9
Diabetes diagnosed by doctor	0.3	0.5	0.8	-0.9	0.2	-0.8
Friendships satisfaction	0.3	0.4	0.7	-0.0	0.8	-0.6
Smoking status: Current	0.3	0.4	0.9	0.6	-0.2	1.0
Average weekly champagne plus white wine intake	0.3	0.4	0.9	-1.0	-0.5	0.0
Guilty feelings	0.3	0.4	0.7	0.3	-0.8	-0.6
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.9	0.9	-0.2	0.0
Medication: Atorvastatin	0.3	0.4	0.5	0.7	-0.7	0.3
Number of operations (self-reported)	0.3	0.4	0.6	-0.5	0.8	0.4
Age started oral contraceptive pill	0.3	0.4	0.6	-0.8	0.5	-0.5
Cholesterol lowering medication	0.3	0.4	0.5	-0.7	-0.7	-0.5
Worry (Nagel 2018)	0.2	0.4	0.7	-0.4	-0.8	-0.5
Alzheimer’s Disease (in mother)	0.2	0.2	0.3	-0.6	-0.4	-0.4
Reaction Time	0.2	0.4	0.9	-0.5	-0.3	-0.9
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	0.7	-0.5	-0.4
Crohns Disease (2012)	0.2	0.3	1.0	1.0	0.1	0.2
Mean Putamen Volume	0.2	0.2	0.4	-0.6	0.3	0.4
Triglycerides	0.2	0.3	0.6	0.0	0.6	0.8
Blood White Count	0.2	1.6	2.5	-0.9	-1.6	-1.2
Smoking Status	0.2	0.4	0.6	-0.5	-0.7	-0.7
Hand grip strength (left)	0.2	0.6	1.2	0.3	1.1	0.7
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.5	-0.3	-0.7	-0.3
Vitamin and mineral supplements	0.2	0.2	0.5	-0.5	0.1	-0.7
High blood pressure	0.2	0.7	1.4	0.3	-0.7	-1.2
Multivitamins +/- minerals	0.2	0.2	0.4	0.2	-0.5	0.6
Alcohol usually taken with meals	0.2	0.3	0.6	0.8	0.0	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	-0.3	-0.1	-0.8
Hair/balding pattern: Pattern 2	0.2	0.3	0.6	0.0	-0.8	0.6
Had menopause	0.2	0.2	0.5	-0.7	0.1	0.3
Financial difficulties in last 2 years	0.2	0.3	0.9	1.0	0.2	0.1
Allergy	0.2	0.6	0.8	-0.5	-0.9	-0.8
Arm fat percentage (right)	0.2	0.6	1.2	1.1	-0.1	0.8
Medication: Paracetamol	0.2	0.3	0.4	-0.2	-0.5	-0.7
Wheeze or whistling in the chest in last year	0.2	0.4	0.9	-0.6	0.9	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.5	-0.5	0.0	-0.7
Pulse wave peak to peak time	0.2	0.3	0.7	0.2	-0.8	-0.2
Medication: Ibuprofen	0.2	0.2	0.6	0.1	-0.2	-0.7
Alcohol intake frequency.	0.2	0.4	1.0	0.1	1.0	0.3
Hypertension (Self-reported)	0.2	0.7	1.2	0.5	-0.7	-1.1
Arm fat percentage (left)	0.2	0.7	1.7	1.3	-0.1	0.7
Qualifications: nursing, teaching	0.2	0.4	1.0	-0.0	-1.0	0.4
Medication for cholesterol	0.2	0.3	0.4	-0.6	-0.5	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.4	-0.4	-0.6	-0.6
Asthma (self-reported)	0.2	0.4	0.6	-0.7	0.6	-0.4
Osteoporosis (self-reported)	0.2	0.2	0.5	-0.7	-0.3	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.1	0.5	-1.0	-0.3
Miserableness	0.2	0.3	1.0	0.0	-0.1	-1.0
Supplements: Calcium	0.2	0.2	0.5	0.0	0.7	-0.4
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	-0.2	0.4	-0.6
Schizophrenia (2018)	0.1	0.1	0.3	-0.1	-0.3	-0.5
Coronary Artery Disease (CAD)	0.1	0.2	0.4	-0.0	-0.3	0.6
LDL Cholesterol	0.1	0.1	0.1	-0.4	-0.4	-0.2
Schizophrenia (2014)	0.1	0.1	0.3	0.0	-0.5	-0.3
Blood Eosinophil Count	0.1	1.1	1.5	1.2	0.5	1.2
BMI	0.1	0.4	0.8	0.3	-0.9	-0.5
Waist Hip Ratio (WHR)	0.1	0.6	1.0	1.0	0.8	0.3
Allergy or Eczema	0.1	0.3	0.8	0.1	0.9	0.1
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.6	-0.1	0.2	-0.8
Hair Pigment	0.1	1.7	3.9	0.1	1.2	2.0
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.1	0.4	-0.1
Medication: Metformin	0.1	0.2	0.5	-0.2	0.1	-0.7
Pack years adult smoking proportion	0.1	0.1	0.2	0.1	0.4	-0.4
Fed-up feelings	0.1	0.2	0.4	0.6	0.5	0.2
Taking other prescription medications	0.1	0.2	0.4	-0.1	-0.4	-0.7
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.5	0.2	-0.1	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	0.5	0.0	0.7
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.5	0.1	-0.1	-0.7
Body mass index (BMI)	0.1	0.4	0.9	0.5	-0.9	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.5	-0.7	-0.2	-0.4
Diabetes (self-reported)	0.1	0.1	0.1	-0.4	0.4	-0.2
Neuroticism score	0.1	0.2	0.7	-0.1	-0.2	-0.8
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.4	0.7	-0.1	-0.0
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	0.4	0.2	-0.5
Asthma	0.1	0.2	0.4	-0.6	0.3	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	0.6	-0.2	0.5
Hair/balding pattern: Pattern 4	0.1	0.1	0.4	-0.0	-0.2	-0.6
Glaucoma (self-reported)	0.1	0.1	0.2	-0.1	0.5	0.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.3	-0.4	-0.0
High blood pressure (siblings)	0.1	0.2	0.6	-0.0	-0.2	-0.8
Leg fat percentage (right)	0.1	0.2	0.4	0.7	-0.3	0.0
Qualifications: College or University degree	0.1	0.4	0.7	0.4	-0.7	0.8
Mean time to correctly identify matches	0.1	0.2	0.4	-0.6	-0.2	-0.6
Illnesses of siblings: Diabetes	0.1	0.2	0.3	0.4	-0.3	0.5
Commuting to job workplace: Walk	0.1	0.2	0.4	-0.2	0.6	-0.2
Osteoarthritis (self-reported)	0.1	0.1	0.2	-0.1	0.4	0.2
Number of self-reported non-cancer illnesses	0.1	0.1	0.3	0.4	-0.1	-0.5
Financial situation satisfaction	0.1	0.1	0.2	0.1	-0.3	0.5
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	-0.5	0.3	-0.3
Medication: Blood pressure	0.1	0.3	0.6	0.4	0.8	0.2
Alcohol drinker status: Never	0.1	0.1	0.2	-0.0	0.2	-0.4
Leg fat percentage (left)	0.1	0.3	0.8	0.9	-0.2	0.0
Pack years of smoking	0.1	0.1	0.2	-0.2	0.4	-0.4
Neuroticism (Nagel 2018)	0.0	0.1	0.2	-0.3	0.1	-0.5
Alzheimer’s Disease (including proxy)	0.0	0.0	0.0	-0.2	-0.1	-0.1
Verbal and Numeric Reasoning (VNR)	0.0	0.0	0.1	-0.3	0.2	-0.1
Blood Platelet Count	0.0	0.3	0.6	0.8	0.3	0.3
Blood Red Count	0.0	0.3	0.5	-0.3	0.7	-0.4
Respiratory disease	0.0	0.1	0.2	-0.1	0.4	0.2
Lung FVC	0.0	0.1	0.2	-0.2	-0.4	-0.4
Tanning	0.0	0.3	0.5	0.7	0.6	-0.2
Sensitivity / hurt feelings	0.0	0.1	0.1	-0.4	0.0	-0.3
Hand grip strength (right)	0.0	0.0	0.1	0.2	0.1	0.3
Fluid intelligence score	0.0	0.0	0.0	-0.0	0.1	0.1
Qualifications: O levels/GCSEs or equivalent	0.0	0.1	0.1	0.3	0.3	0.0
High cholesterol (Self-reported)	0.0	0.1	0.2	0.2	-0.4	0.0

Hub : Genes

STOML3

Models

Trait associations