TWAS hub - PELI2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.141	0.0290	1.9e-10	0.110	0.104	0.097	0.110	0.104	2.8e-13	1.4e-12	8.3e-12	2.4e-13	1.2e-12
2	GTEx	Brain Putamen basal ganglia	0.295	0.0930	4.0e-03	0.012	NA	-0.011	NA	0.005	1.6e-01	NA	7.3e-01	NA	2.4e-01
3	GTEx	Cells EBV-transformed lymphocytes	0.251	0.0870	3.6e-03	-0.009	NA	-0.004	NA	-0.006	9.5e-01	NA	4.4e-01	NA	5.5e-01
4	GTEx	Cells Transformed fibroblasts	0.143	0.0530	4.6e-03	0.069	NA	0.117	NA	0.096	6.8e-06	NA	4.2e-09	NA	1.2e-07
5	GTEx	Esophagus Muscularis	0.157	0.0620	5.3e-03	-0.004	NA	0.011	NA	0.002	6.3e-01	NA	6.6e-02	NA	2.3e-01
6	GTEx	Nerve Tibial	0.140	0.0465	8.5e-04	0.090	NA	0.058	NA	0.089	6.6e-07	NA	5.9e-05	NA	7.0e-07
7	YFS	Blood	0.055	0.0133	6.3e-08	0.032	0.025	0.033	0.031	0.034	1.0e-10	9.8e-09	6.3e-11	1.3e-10	2.5e-11
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.107	0.0403	1.7e-06	-0.002	0.065	0.047	NA	0.034	7.2e-01	8.7e-08	4.7e-06	NA	9.5e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	6	7	8
Frequency of unenthusiasm / disinterest in last 2 weeks	3.2	4.2	17.5	2.6	-4.2	-1.2	-2.4	0.6	-0.9	-1.1
Wheeze or whistling in the chest in last year	3.2	5.7	14.4	3.0	-3.1	-3.1	-3.8	-0.4	-1.1	-1.0
Tinnitus: Yes, but not now, but have in the past	3.1	3.3	12.2	1.1	-2.9	-1.8	-3.5	0.3	-0.2	-0.9
Qualifications: CSEs or equivalent	3.0	4.0	10.6	2.1	-3.2	-2.4	-2.7	1.4	-1.4	0.6
Neuroticism (2016)	2.5	3.7	9.7	2.7	-3.0	-1.3	-3.1	-1.1	0.1	-0.7
Depression (Nagel 2018)	2.4	3.7	13.7	2.4	-3.7	-2.1	-2.0	0.3	-0.3	-1.3
Heart disease (siblings)	2.1	2.6	9.6	0.6	0.3	-0.9	3.1	3.1	-0.8	0.0
Mean Putamen Volume	2.0	2.3	7.9	-2.8	2.0	0.5	2.3	0.2	0.9	0.6
Mouth/teeth dental problems: Loose teeth	2.0	2.4	9.3	3.0	-1.2	-0.3	-1.3	-1.6	-2.0	-0.5
Rheumatoid Arthritis	1.9	2.7	7.1	2.1	0.6	0.1	2.7	0.5	-1.6	2.5
Stomach or abdominal pain in last month	1.9	2.4	6.9	2.2	-1.3	-0.6	-2.0	0.1	-1.2	-2.6
Trunk fat mass	1.9	8.0	31.8	-2.7	3.0	2.5	-0.0	-5.6	2.2	-2.3
Average weekly champagne plus white wine intake	1.9	2.6	12.8	-1.4	1.2	3.6	0.4	-1.6	1.2	-0.6
Alcohol drinker status: Never	1.9	2.3	8.7	-0.2	-0.4	0.4	-2.3	1.9	0.3	-3.0
Commuting to job workplace: Cycle	1.9	2.3	9.3	1.3	-0.4	-1.3	1.4	1.3	-1.5	3.0
Ever used hormone-replacement therapy (HRT)	1.8	2.3	6.2	2.0	-2.5	-2.0	-1.1	0.8	-1.6	-0.0
Chronic bronchitis/emphysema (mother)	1.8	2.1	7.0	1.2	-1.8	-0.5	0.3	0.2	-2.1	2.6
Number of full brothers	1.8	2.3	7.9	-0.5	-2.2	-2.8	-1.4	-1.1	0.3	1.4
Illnesses of father: None of the above (group 1)	1.8	2.2	5.6	-2.0	-0.1	0.6	-2.4	-0.9	1.8	-1.9
Unable to work because of sickness or disability	1.8	2.4	11.5	0.1	-3.4	-1.3	-1.5	-0.1	1.7	-0.8
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.7	8.5	2.9	-2.7	-1.2	-1.3	1.3	-0.2	-1.1
Number of live births	1.7	2.4	4.8	1.4	-1.0	-1.5	1.4	2.1	-2.2	1.7
Medication: Blood pressure	1.7	3.0	7.2	0.0	2.4	2.7	2.0	-0.5	-1.4	2.2
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	6.7	1.6	-2.6	-2.3	-1.2	-0.0	-0.8	-0.1
Illnesses of father: Heart disease	1.7	2.4	9.1	3.0	-0.8	-1.1	1.2	-0.0	-2.2	1.4
Schizophrenia (2018)	1.6	3.3	12.0	1.4	-1.3	-3.5	0.7	1.6	-0.7	2.7
Schizophrenia (2014)	1.6	3.6	12.1	1.5	-0.9	-3.5	1.5	1.2	-0.4	3.1
Trunk fat percentage	1.6	6.3	26.1	-2.4	2.8	1.8	-0.2	-5.1	2.0	-1.8
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	4.8	2.2	-1.4	-0.2	0.8	0.3	-2.0	2.0
Qualifications: College or University degree	1.6	4.9	14.5	-2.0	2.8	1.2	2.6	2.1	3.8	-0.8
Whole body fat mass	1.6	6.6	28.8	-2.3	2.4	2.3	-0.1	-5.4	1.8	-2.0
Breast cancer (self-reported)	1.6	1.9	4.5	-1.5	2.1	1.1	0.1	-0.0	2.1	-1.7
Pain experienced in last month	1.6	2.6	9.1	1.1	1.3	-1.1	2.2	1.2	-1.2	3.0
Leg fat mass (left)	1.6	6.2	33.7	-2.3	1.5	2.1	-0.3	-5.8	1.3	-1.5
Triglycerides	1.5	2.5	4.2	-2.0	1.8	0.6	-0.7	-1.8	2.1	-2.0
Waist circumference	1.5	5.5	23.3	-2.2	2.1	2.4	-0.0	-4.8	1.7	-1.6
Hair/balding pattern: Pattern 2	1.5	1.9	10.2	-3.2	-0.4	-0.4	-0.6	0.6	1.7	-1.2
Financial difficulties in last 2 years	1.5	2.0	4.9	1.7	-2.2	-2.1	-1.9	0.2	-0.2	0.5
Weight	1.5	7.4	26.8	-2.5	2.7	3.4	0.5	-5.2	1.7	-2.2
Lung cancer (father)	1.5	1.8	4.5	2.1	-2.1	-1.6	-0.6	1.0	-1.1	0.6
Ever highly irritable/argumentative for 2 days	1.5	1.8	4.8	2.2	-1.9	-0.8	-0.9	0.6	-2.0	0.8
Eye problems/disorders: None of the above	1.5	1.8	3.9	-1.9	-0.4	-2.0	-1.5	-1.8	0.5	-0.8
Neck or shoulder pain in last month	1.5	2.1	10.1	-0.0	-1.9	-0.2	-1.7	-0.3	0.5	-3.2
Leg fat mass (right)	1.5	5.7	31.1	-2.3	1.2	2.0	-0.4	-5.6	1.3	-1.4
Medication: Atorvastatin	1.5	1.9	4.2	0.6	1.9	1.0	2.0	0.4	-1.8	1.7
Leg fat percentage (left)	1.5	5.5	34.4	-2.0	0.6	1.2	-1.1	-5.9	1.0	-1.1
Bipolar Disorder or Schizophrenia	1.4	3.5	14.7	1.9	-1.4	-3.8	0.5	1.0	-0.9	2.4
Type 2 Diabetes (T2D) (2012)	1.4	1.6	4.4	-1.1	0.5	1.5	-0.3	-1.0	2.1	-2.0
Supplements: Glucosamine	1.4	1.8	4.4	-2.1	1.5	0.7	1.3	-2.0	1.1	-0.8
Mouth/teeth dental problems	1.4	2.2	7.7	-2.8	0.9	1.0	-1.5	-1.8	0.4	-1.4
Pain all over the body in last month	1.4	1.5	5.0	0.4	-2.2	-1.2	-1.8	-1.2	0.7	-0.3
Body fat percentage	1.4	5.7	27.6	-2.3	2.1	1.5	-0.5	-5.3	1.7	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	5.3	0.9	-2.1	-0.8	-2.3	0.4	-0.6	-1.1
Back pain experienced in last month	1.4	2.0	11.0	-0.7	0.3	1.5	-0.9	-3.3	0.8	-0.9
Guilty feelings	1.4	2.1	8.2	-0.2	-1.8	-1.0	-2.9	0.9	0.6	-1.7
Ever had prostate specific antigen (PSA) test	1.4	1.6	5.6	2.1	0.4	0.5	2.4	1.1	-1.2	0.1
Depressed Affect (Nagel 2018)	1.3	2.8	8.5	1.8	-2.9	-0.8	-1.9	-1.5	0.2	-2.0
Intelligence (Savage-Jansen 2018)	1.3	4.0	10.0	-0.9	2.2	3.2	2.8	1.3	2.6	-0.3
Type 2 Diabetes (T2D) (2018)	1.3	2.5	7.8	-1.1	0.4	1.9	-2.0	-0.2	1.7	-2.8
Ever unenthusiastic/disinterested for a whole week	1.3	1.5	5.0	2.2	-0.5	0.4	1.0	2.0	-1.0	0.8
Falls in the last year	1.3	1.7	4.8	-0.2	-1.4	-2.2	-2.0	0.7	0.6	-1.4
Arm fat mass (right)	1.3	5.2	21.3	-2.3	2.2	2.4	0.7	-4.6	1.5	-1.4
Medication: Amlodipine	1.3	1.9	8.9	0.6	0.5	1.2	1.2	-0.2	-1.7	3.0
Leg fat percentage (right)	1.3	4.7	29.1	-2.0	0.1	1.1	-1.1	-5.4	1.1	-1.1
Pulse rate, automated reading	1.3	4.1	16.2	-1.2	4.0	1.4	3.4	-0.2	0.4	1.4
Chest pain or discomfort	1.3	1.9	6.5	1.6	-2.5	-0.1	-0.7	1.8	0.9	-1.4
Mood swings	1.3	2.3	6.1	2.4	-2.5	-0.5	-1.9	-1.3	-1.1	-0.3
Eye problems/disorders: Cataract	1.3	1.5	4.3	1.7	0.7	1.0	2.1	0.9	-0.5	1.4
Osteoarthritis (self-reported)	1.3	1.7	8.1	-0.7	0.1	0.9	1.1	-2.8	1.6	0.6
Neuroticism (Nagel 2018)	1.2	2.7	7.4	1.3	-2.7	-0.3	-2.3	-0.9	0.9	-2.4
Neuroticism	1.2	3.0	6.9	0.6	-2.6	-1.0	-2.3	-0.3	2.1	-2.4
Hearing difficulty/problems: Yes	1.2	1.8	4.6	2.1	2.1	1.2	-0.1	0.4	-1.4	-1.4
Chronic bronchitis/emphysema (father)	1.2	1.4	6.1	0.8	-0.6	-1.0	2.5	1.2	-0.5	1.2
Hip circumference	1.2	5.3	23.4	-1.8	2.1	2.6	0.5	-4.8	1.4	-1.4
Noisy workplace	1.2	1.4	5.7	1.1	-1.2	-2.4	0.7	0.1	-0.2	1.6
Illnesses of mother	1.2	1.4	3.8	-0.2	-1.2	-0.1	-1.9	1.6	1.5	-1.2
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	6.1	1.7	-1.8	-1.3	1.4	1.7	-0.7	2.5
Number of full sisters	1.2	1.5	4.1	-1.7	-0.7	-1.1	-1.6	0.6	2.0	-0.5
Ever had bowel cancer screening	1.2	1.4	4.2	1.5	1.1	-0.9	0.9	0.1	-2.1	-1.4
Arm fat mass (left)	1.2	5.0	22.0	-2.2	2.2	2.1	0.5	-4.7	1.4	-1.4
Hearing aid user	1.2	1.3	6.0	2.5	-0.1	-0.2	0.6	1.6	-1.1	0.6
Smoking Status	1.1	2.6	7.0	2.4	-2.7	-1.7	-1.7	0.8	-1.2	0.4
Hypothyroidism (self reported)	1.1	2.5	5.9	1.5	-2.3	-1.0	0.7	2.2	-0.2	2.4
Vitamin and mineral supplements	1.1	1.5	5.2	0.3	-2.3	-0.1	0.1	0.7	-1.3	2.1
Emphysema/chronic bronchitis	1.1	1.2	3.7	1.5	-1.9	-0.9	-1.4	0.4	0.0	0.8
Migraine (self-reported)	1.1	1.4	7.0	-2.6	0.5	-1.2	-0.3	-0.7	1.4	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.2	1.5	-1.8	-1.5	-1.2	-0.2	-0.0	-1.1
Supplements: Vitamin C	1.1	1.3	3.6	0.3	1.5	1.4	-0.1	1.9	0.6	-1.5
Average weekly red wine intake	1.1	1.6	3.6	-0.1	1.7	0.7	1.9	1.9	0.9	-1.2
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	8.0	-0.6	0.1	-0.8	0.3	1.8	2.8	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.1	-1.2	1.5	0.9	1.4	-0.6	1.8	-0.2
Financial situation satisfaction	1.1	1.3	2.9	1.1	-1.6	-0.4	-1.6	-0.6	-1.7	0.9
Ever smoked	1.1	2.0	6.2	2.5	-2.3	-0.7	-1.9	-0.3	0.3	-0.5
Primary Biliary Cirrhosis	1.0	1.4	4.2	1.2	0.3	2.0	1.6	0.0	-1.6	0.9
Average weekly fortified wine intake	1.0	1.2	4.2	0.7	0.6	1.8	-0.1	2.0	0.8	-0.9
Taking other prescription medications	1.0	1.5	3.5	1.7	-1.1	-1.9	-0.6	1.9	-0.9	0.2
Diabetes (self-reported)	1.0	1.5	4.9	-0.1	0.7	1.2	-0.2	1.4	1.7	-2.2
Arm fat percentage (right)	1.0	3.8	14.7	-2.2	1.7	1.7	0.4	-3.8	1.8	-1.1
Medication: Lansoprazole	1.0	1.1	3.6	-1.0	-0.9	-1.2	-1.9	-1.4	-0.1	-0.5
Prospective memory result	1.0	1.3	3.9	0.8	-0.4	-0.3	1.0	1.2	-1.6	2.0
Exposure to tobacco smoke at home	1.0	1.1	3.4	-0.5	-0.2	-1.2	-1.1	-0.3	1.9	-1.5
Birth weight	1.0	2.1	7.5	-2.2	-0.0	-0.0	-0.6	0.3	2.7	-2.0
Had major operations	1.0	1.1	3.7	-1.1	-0.1	-1.5	-0.4	-0.2	1.3	-1.9
Diabetes diagnosed by doctor	1.0	1.7	4.6	-1.0	1.1	1.9	-0.3	0.2	1.7	-2.1
Asthma (self-reported)	1.0	1.9	5.7	2.4	-1.1	-1.8	-0.0	0.4	-1.7	1.4
Miserableness	1.0	1.7	4.9	0.9	-1.6	0.9	-2.1	-0.3	0.1	-2.2
Commuting to job workplace: Public transport	1.0	1.2	3.5	-0.3	1.4	0.6	0.6	1.9	1.5	-1.0
Risk taking	1.0	1.4	3.4	1.6	-1.7	-1.2	0.2	1.8	0.3	-1.0
Cholesterol lowering medication	1.0	1.5	7.7	1.3	0.2	0.8	0.4	-1.2	-2.8	0.6
Pack years of smoking	1.0	1.5	3.9	-0.3	-0.7	1.6	-1.8	-0.6	1.3	-2.0
Schizophrenia vs Biploar Disorder	0.9	1.2	3.7	-1.1	-1.1	-1.4	-0.8	-0.6	1.9	-0.7
Age at First Birth	0.9	1.4	5.2	-1.4	2.3	1.2	0.6	-0.6	1.0	0.7
HDL Cholesterol	0.9	1.6	7.1	0.9	-0.1	-0.2	1.6	1.2	-0.8	2.7
Chronotype (morning person)	0.9	2.1	6.3	2.5	-1.0	0.7	-1.7	-1.7	-1.4	-0.8
Angina	0.9	1.2	6.7	0.7	0.1	-0.3	-1.0	0.4	1.1	-2.6
Mouth/teeth dental problems: Dentures	0.9	1.5	4.3	1.4	-0.2	-0.3	2.0	-0.2	-1.2	2.1
Asthma	0.9	1.7	4.8	2.2	-1.3	-1.9	-0.1	0.3	-1.3	1.4
Tense / ‘highly strung’	0.9	1.5	4.2	0.1	-0.9	-0.4	-1.6	-2.1	1.4	-1.5
Peak expiratory flow (PEF)	0.9	2.0	5.5	-2.3	2.1	0.9	1.4	-1.3	1.1	0.8
Comparative body size at age 10	0.9	2.5	4.5	-1.7	1.5	2.1	1.1	-1.3	2.0	-2.0
Arm fat percentage (left)	0.9	3.7	15.8	-2.0	1.8	1.5	0.3	-4.0	1.7	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	5.1	-2.1	1.3	1.0	1.1	0.3	1.5	-2.3
Medication: Lisinopril	0.9	1.2	3.3	0.2	1.8	1.8	-0.1	-1.4	0.1	-0.9
Basal metabolic rate	0.9	5.0	13.7	-2.0	2.4	3.3	1.0	-3.7	1.1	-1.9
Arm fat-free mass (left)	0.9	4.6	17.8	-1.9	1.7	2.9	0.8	-4.2	0.5	-1.8
Heart attack/myocardial infarction (self-reported)	0.9	1.1	4.0	0.1	-0.7	-2.0	-1.6	-0.3	-0.1	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	3.5	0.5	-0.9	-1.9	-0.8	0.0	-1.1	-1.6
Arm predicted mass (left)	0.9	4.4	16.6	-1.7	1.7	3.0	0.9	-4.1	0.4	-1.7
Worry (Nagel 2018)	0.8	1.7	5.9	-0.0	-0.6	0.1	-1.9	-1.3	1.3	-2.4
Alzheimer’s Disease (in father)	0.8	0.9	4.9	0.9	-2.2	-0.1	-1.1	-0.2	-0.2	-0.0
Crohns Disease (2017)	0.8	1.8	9.2	1.1	0.4	0.0	1.9	3.0	0.2	0.8
Irritable Bowel Disease (IBD)	0.8	1.9	7.1	1.5	0.8	-0.7	1.6	2.7	-0.8	1.4
Breast Cancer	0.8	1.9	7.6	-0.4	0.7	-0.0	-2.8	-1.5	-0.0	-2.2
Frequency of depressed mood in last 2 weeks	0.8	1.1	4.3	0.9	-2.1	-1.5	-0.8	0.5	-0.3	-0.9
Diabetes (father)	0.8	1.0	4.1	-0.3	-0.7	-1.1	-0.2	-1.1	2.0	-0.7
Pack years adult smoking proportion	0.8	1.2	3.0	-0.3	-0.8	1.7	-1.4	-0.5	1.2	-1.6
Townsend deprivation index at recruitment	0.8	1.1	3.8	-0.2	-1.9	-0.7	-1.9	0.2	0.9	-0.6
Fed-up feelings	0.8	1.5	4.4	1.8	-2.1	-0.0	-1.7	-0.7	-0.0	-0.7
Hayfever, allergic rhinitis or eczema	0.8	1.8	7.1	-1.3	0.1	0.3	-1.0	0.4	2.1	-2.7
Medication: Levothyroxine sodium	0.8	1.3	3.1	1.8	-0.9	-0.5	1.0	0.9	-1.4	1.5
Body mass index (BMI)	0.8	3.4	18.1	-1.7	1.0	1.9	0.7	-4.3	0.6	-0.6
Past tobacco smoking	0.8	1.5	5.6	-2.2	2.4	1.1	0.9	-0.0	0.0	-0.3
Trunk fat-free mass	0.8	4.3	11.5	-1.9	2.0	3.4	1.2	-3.1	0.8	-1.9
Time employed in main current job	0.8	0.9	3.5	1.9	0.2	-0.5	0.3	0.2	-1.8	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.7	5.3	-2.3	1.8	1.9	1.6	-0.5	1.9	-1.7
Blood clot in the leg (DVT)	0.8	1.0	3.8	0.4	-0.8	-2.0	-0.7	-0.2	-1.1	-1.2
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.3	-0.2	-1.7	-1.8	-1.2	0.2	1.1	-1.2
Medication: Ventolin 100micrograms inhaler	0.8	1.0	3.2	1.3	-0.8	0.0	-0.4	-0.6	-1.8	1.5
Arm predicted mass (right)	0.8	3.9	13.9	-1.6	1.8	2.7	0.9	-3.7	0.2	-1.7
Medication: Aspirin	0.8	1.0	4.9	-0.2	2.2	1.6	0.8	0.2	-0.1	-0.3
Loneliness, isolation	0.8	1.0	3.3	-0.4	-1.0	-1.2	-0.3	-1.2	1.8	-1.0
Medication: Aspirin	0.8	1.0	4.5	-0.3	2.1	1.3	0.5	0.8	-0.2	-0.8
Fractured/broken bones in last 5 years	0.8	1.0	2.1	-1.3	1.1	-1.5	1.3	0.5	1.2	-0.1
Age started oral contraceptive pill	0.8	1.0	3.4	-0.9	0.2	1.3	-0.2	-0.7	1.8	-1.1
Major Depression (MDD)	0.7	0.8	3.2	1.8	-0.2	0.8	-1.4	-0.2	0.6	-0.4
Prostate Cancer	0.7	1.0	4.0	-1.2	0.0	0.1	0.6	-0.3	2.0	-1.5
Coronary Artery Disease (CAD)	0.7	0.8	2.9	1.4	-1.7	-0.6	-0.3	0.2	-1.0	0.6
HbA1C	0.7	0.8	2.8	0.3	0.9	0.3	1.4	1.7	-0.6	0.2
Average weekly spirits intake	0.7	0.8	3.5	0.4	1.0	1.9	-0.5	0.2	-0.7	-1.1
Supplements: Zinc	0.7	0.7	2.5	0.2	1.6	-0.3	0.3	0.7	0.5	-1.6
Diabetes (mother)	0.7	0.9	3.3	-0.5	0.9	1.8	0.1	-1.4	-0.5	0.7
Leg fat-free mass (left)	0.7	3.6	8.4	-1.5	2.3	2.9	1.1	-2.9	1.1	-1.5
Serious illness, injury or assault to yourself	0.7	0.9	3.4	-0.2	0.2	1.0	1.8	1.1	0.2	1.3
Multivitamins +/- minerals	0.7	0.9	2.6	-0.6	0.9	-0.7	-1.0	-0.3	1.3	-1.6
Alcohol usually taken with meals	0.7	1.1	4.9	1.1	0.6	0.6	2.2	1.3	0.6	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	8.2	0.3	-0.7	0.2	-0.3	0.1	0.5	-2.9
Depression (self-reported)	0.7	0.9	1.7	0.5	0.6	1.3	0.8	-1.1	1.3	-1.1
Trunk predicted mass	0.7	4.0	10.6	-1.9	1.9	3.2	1.1	-3.0	0.8	-1.9
Standing height	0.7	6.9	14.2	-1.8	3.8	3.6	-0.3	-2.5	2.3	-3.6
Breastfed as a baby	0.7	0.8	3.6	-1.4	-1.9	-0.6	0.1	0.3	0.5	-0.5
Arm fat-free mass (right)	0.7	3.8	14.0	-1.5	2.0	2.5	0.8	-3.7	0.1	-1.8
Shortness of breath walking on level ground	0.7	0.8	3.4	1.9	-0.5	0.2	0.4	0.2	-1.5	0.5
Angina (self-reported)	0.7	1.0	5.5	0.5	0.1	-0.4	-0.8	0.3	1.0	-2.3
Comparative height size at age 10	0.7	4.0	6.5	-2.4	2.5	1.9	-0.3	-2.2	2.6	-2.2
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.9	1.6	-0.2	0.7	0.5	-0.0	-1.7	0.5
Smoking status: Previous	0.7	1.1	3.0	1.7	-1.7	-1.3	0.2	-0.2	-0.4	1.0
Whole body fat-free mass	0.7	4.1	9.9	-1.8	2.2	3.1	1.2	-3.1	0.8	-1.7
Leg fat-free mass (right)	0.7	3.6	8.6	-1.3	2.6	2.9	1.2	-2.7	0.8	-1.5
Handedness (chirality/laterality): Left-handed	0.7	0.9	2.4	1.1	-1.5	-0.3	-1.0	1.2	0.5	-0.8
Qualifications: nursing, teaching	0.7	1.0	3.6	-0.6	1.3	0.8	1.9	0.7	0.2	-1.1
Medication for cholesterol	0.7	1.1	4.1	-0.6	-0.7	-1.3	-0.2	1.5	2.0	-0.4
Osteoporosis (self-reported)	0.7	0.9	2.5	1.1	-0.7	-0.9	-0.8	1.6	0.7	-0.9
Whole body water mass	0.7	4.2	10.4	-1.8	2.1	3.2	1.2	-3.2	0.8	-1.9
Leg predicted mass (right)	0.7	3.7	9.0	-1.4	2.6	3.0	1.2	-2.8	0.9	-1.4
Number of self-reported non-cancer illnesses	0.7	1.2	2.6	1.4	-1.4	-1.6	0.3	-0.3	-1.3	1.1
Ever taken oral contraceptive pill	0.7	0.8	1.5	1.2	-1.1	0.9	-1.0	-0.6	-0.6	-0.8
Pain type(s) experienced in last month: Hip pain	0.7	0.9	3.1	0.4	-0.5	1.4	0.4	-1.8	0.9	-0.5
Alcohol drinker status: Previous	0.7	0.8	2.7	-1.0	0.5	1.0	1.6	-0.8	1.0	0.3
Alzheimer’s Disease (including proxy)	0.6	0.9	3.4	1.0	-1.8	0.0	0.0	-0.3	-1.3	1.0
Bipolar Disorder (2011)	0.6	0.5	1.8	1.0	1.3	-0.3	1.0	0.0	0.5	0.1
Body Mass Index (BMI) (2010)	0.6	0.8	2.2	-1.1	0.7	-0.4	-0.7	-1.2	0.4	-1.5
LDL Cholesterol	0.6	1.0	2.4	1.0	-1.3	-1.6	-0.5	0.7	0.8	-1.2
Ulcerative Colitis	0.6	0.9	2.0	1.4	0.4	-0.9	0.7	1.0	-0.7	1.4
BMI	0.6	3.6	22.5	-1.6	0.7	1.4	-0.7	-4.7	0.2	-0.9
Systolic Blood Pressure	0.6	3.2	10.3	0.2	1.8	1.6	2.2	-0.4	-2.1	3.2
Allergy or Eczema	0.6	1.7	6.1	-0.6	-0.5	-0.4	-1.5	-0.2	2.1	-2.5
Hand grip strength (left)	0.6	1.5	6.2	-2.5	1.1	-0.5	0.2	-1.3	0.3	1.6
Systolic blood pressure, automated reading	0.6	1.7	3.5	-1.2	1.3	1.4	1.5	-1.4	-1.1	1.9
Relative age voice broke	0.6	0.9	2.3	-0.2	1.4	1.1	1.0	-0.4	-0.5	1.5
High blood pressure (mother)	0.6	0.9	3.3	-0.5	0.9	-0.8	1.0	-1.8	-0.7	0.6
Leg predicted mass (left)	0.6	3.4	8.5	-1.5	2.2	2.8	1.0	-2.9	0.9	-1.4
Hearing difficulty/problems with background noise	0.6	0.9	2.4	1.5	1.2	1.1	0.3	-0.6	0.4	-1.4
Had other major operations	0.6	0.7	2.3	-0.1	1.5	0.5	0.7	0.5	-1.4	-0.3
Heart attack	0.6	0.8	3.0	0.2	-0.6	-1.7	-1.3	-0.4	-0.2	-1.1
Neuroticism score	0.6	1.2	2.6	0.2	-1.4	0.1	-1.6	-0.6	1.4	-1.6
Forced expiratory volume in 1-second (FEV1)	0.6	2.2	4.4	-2.0	2.1	1.7	1.0	-0.2	1.9	-1.1
Pulse rate	0.6	1.0	3.2	-0.4	1.8	1.3	0.7	-0.3	1.1	-1.1
Hair/balding pattern: Pattern 4	0.6	1.3	4.2	2.1	0.7	-0.5	-0.7	-0.7	-2.0	-0.9
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.9	1.0	0.8	-0.3	1.2	1.3	-1.4	-1.1
Headache pain in last month	0.6	1.1	3.1	1.4	-1.1	0.1	-1.8	0.0	-1.0	-1.2
Forced vital capacity (FVC), Best measure	0.6	2.2	4.6	-2.1	1.6	1.5	1.2	-0.8	1.9	-1.4
Exposure to tobacco smoke outside home	0.6	0.8	2.1	0.6	0.1	-1.2	-1.5	-0.6	-0.8	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.9	-0.4	-0.1	-1.3	0.1	1.7	0.2	-0.8
Medication: Allopurinol	0.6	0.8	2.5	-1.3	-1.1	0.2	-0.3	0.3	1.6	-0.8
Medication: Seretide 50 evohaler	0.6	0.7	1.9	1.0	-0.1	-0.8	-0.9	0.1	1.2	-1.4
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.1	0.5	1.0	1.4	1.4	0.1	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	4.4	0.4	0.7	0.4	-1.0	-2.1	-1.6	0.6
Long-standing illness, disability or infirmity	0.6	0.9	4.2	2.1	-1.6	0.1	0.1	0.1	0.4	-0.3
Mineral and other dietary supplements	0.6	0.8	4.1	0.3	-2.0	-0.9	-0.9	0.6	0.1	0.5
Medication: Gliclazide	0.6	0.7	2.2	-1.1	1.5	-0.7	0.0	1.0	0.8	-0.3
Mother’s age at death	0.6	0.7	1.9	0.6	-0.2	-1.3	-0.3	1.3	0.2	-1.4
Irritability	0.6	1.1	4.0	0.3	-2.0	-0.4	-1.7	-0.6	1.0	0.2
Diastolic blood pressure, automated reading	0.6	1.7	3.3	-1.7	1.6	1.8	0.8	-1.7	-0.3	1.1
Ever depressed for a whole week	0.6	0.8	2.2	1.5	-0.9	0.2	0.0	1.1	-1.3	0.4
Supplements: Calcium	0.6	0.7	2.0	-0.3	0.9	-1.2	1.4	0.7	0.2	-0.7
Basal cell carcinoma (self-reported)	0.6	0.7	2.3	1.5	1.4	0.0	-0.1	0.0	-1.1	-0.3
Ulcerative Colitis (UC)	0.5	1.0	3.0	1.1	0.7	-0.7	1.2	1.7	-0.9	0.8
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.7	-0.0	1.9	1.1	1.6	0.4	1.6	0.1
Respiratory disease	0.5	1.1	3.0	1.7	-0.3	-1.5	0.4	0.7	-1.2	1.0
Sensitivity / hurt feelings	0.5	0.9	3.3	0.3	-1.8	0.9	-1.1	0.1	0.4	-1.2
Medication: Metformin	0.5	0.8	2.6	0.2	1.6	0.6	1.3	0.2	1.0	-0.5
Severe depression (siblings)	0.5	0.5	1.5	-0.3	0.5	1.2	0.5	-0.1	1.2	-0.6
High blood pressure	0.5	1.5	3.7	0.6	1.3	1.3	0.6	-1.9	-1.1	1.7
Medication: Atenolol	0.5	0.7	2.7	-0.0	0.2	1.6	-0.6	-0.4	-1.4	0.3
Number of incorrect matches in round	0.5	0.7	3.4	0.6	-0.2	-1.0	-0.3	-1.0	0.5	-1.8
Nervous feelings	0.5	1.0	2.2	-0.7	-0.1	0.4	-1.2	-1.1	1.5	-1.5
Forced vital capacity (FVC)	0.5	2.0	4.5	-1.8	2.1	2.1	1.2	-0.2	1.4	-0.8
Qualifications: None of the above	0.5	1.1	5.4	-0.1	-1.3	-0.2	-1.0	-2.3	0.2	0.9
Fluid intelligence score	0.5	1.0	3.8	-1.2	1.2	0.6	0.9	0.1	1.9	-0.5
Illnesses of siblings	0.5	0.7	4.0	-0.0	-0.1	0.9	-2.0	-0.7	-0.4	-0.4
Pulse wave Arterial Stiffness index	0.5	0.5	2.7	-0.6	0.5	0.1	0.6	-1.6	0.7	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	3.2	0.3	-0.7	0.6	-0.1	1.1	0.7	-1.8
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.1	1.4	-1.1	-0.4	-0.5	0.9	0.9	-0.5
Heart disease (mother)	0.5	0.7	2.6	1.6	0.6	0.2	0.3	-0.1	-0.3	-1.5
Alcohol intake frequency.	0.5	1.3	3.8	-0.8	-1.3	1.3	-1.3	-0.0	0.7	-2.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	2.6	-0.1	0.3	-0.4	-0.3	1.6	-0.0	-1.3
High cholesterol (Self-reported)	0.5	0.9	2.9	-1.1	1.3	0.5	1.7	-0.4	-1.2	0.1
Medication: Paracetamol	0.5	0.8	2.5	1.6	-0.8	0.8	0.3	-0.1	-1.4	0.8
Myopia	0.5	0.7	4.3	-0.3	-0.3	-2.1	0.1	-0.2	0.9	0.7
Bipolar Disorder (2018)	0.4	0.6	2.5	1.2	-0.5	-1.6	-0.2	-0.3	-0.5	0.5
Alzheimer’s Disease (in mother)	0.4	0.4	3.2	0.1	0.0	0.4	1.8	0.2	-0.3	0.2
Crohns Disease (2012)	0.4	0.6	3.0	0.7	-0.3	0.4	1.0	1.7	-0.1	0.3
Height	0.4	8.6	26.9	-1.9	5.2	3.8	0.7	-2.8	2.5	-2.9
Medication for hormone replacement therapy	0.4	0.4	1.6	-0.4	0.3	0.6	-0.9	-1.3	-0.6	0.1
Medication: Co-codamol	0.4	0.4	1.0	0.9	-0.8	-0.7	-0.6	-0.5	-0.0	1.0
Hand grip strength (right)	0.4	1.0	5.1	-2.3	0.8	-0.4	0.3	-0.1	0.4	1.3
Current tobacco smoking	0.4	0.7	2.1	0.9	-1.4	0.1	-0.9	0.7	-1.1	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.2	0.5	0.0	0.7	1.0	1.1	-1.5	1.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.3	0.8	0.7	-0.4	1.0	-0.7	-1.1	0.3
Impedance of leg (left)	0.4	1.8	8.6	-0.9	-0.7	-1.0	-2.9	-1.0	1.0	-1.2
Allergy	0.4	0.9	3.5	-0.3	1.0	0.6	1.4	-0.4	-0.5	1.9
Impedance of arm (right)	0.4	1.8	7.5	-0.0	0.3	-0.2	-1.7	1.6	2.7	-1.2
Hair/balding pattern: Pattern 3	0.4	0.6	1.3	0.7	-0.7	1.1	-0.2	0.7	-0.9	1.2
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.7	-0.1	1.6	0.2	1.2	1.2	-0.3	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.8	-0.1	-1.3	-0.5	0.6	-0.1	1.0	0.9
Gout (self-reported)	0.4	0.6	2.3	-0.2	-1.5	-1.0	0.6	0.7	0.7	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.8	-0.1	-1.4	0.2	-0.6	-0.1	0.9	-1.0
Health satisfaction	0.4	0.5	1.9	0.2	-0.1	1.0	0.3	-0.8	0.8	-1.4
Suffer from ‘nerves’	0.4	0.7	2.6	0.2	0.3	1.6	-0.2	-1.5	0.3	-0.6
Age at last live birth	0.4	0.5	2.1	0.5	0.1	-1.0	0.4	1.5	-0.4	0.7
Family relationship satisfaction	0.4	0.4	1.9	1.4	1.1	0.0	-0.3	-0.5	-0.2	-0.1
Friendships satisfaction	0.4	0.5	2.3	-0.6	1.5	0.7	0.1	-0.8	0.4	-0.7
Wears glasses or contact lenses	0.4	0.4	1.5	-1.0	1.2	0.1	0.5	-0.4	0.6	-0.2
Medication: Bendroflumethiazide	0.4	0.7	2.6	0.3	0.9	1.6	0.3	-0.3	-0.9	0.9
Illnesses of father: High blood pressure	0.4	0.5	1.8	-0.9	-0.3	-1.4	0.3	0.8	0.4	0.3
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.2	-0.8	-1.1	-0.7	-0.3	1.5	1.2	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.1	-0.7	-0.9	-0.7	-0.7	-0.6	0.0	-1.1
Ovarian Cancer	0.3	0.4	0.9	0.3	0.5	-0.6	0.5	0.8	-0.7	-0.9
Lupus	0.3	0.4	1.4	0.4	-0.3	-1.0	-1.2	-0.1	0.4	-0.4
Waist Hip Ratio (WHR)	0.3	1.3	4.3	-2.1	0.5	0.4	-1.1	-1.0	1.9	-0.2
Lung FVC	0.3	1.5	5.8	-0.4	1.2	0.8	2.4	1.9	0.5	-0.2
Relative age of first facial hair	0.3	0.6	2.6	-1.2	-0.1	-0.5	-0.9	-1.6	0.2	0.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.6	-0.2	0.0	0.3	0.6	0.4	0.8	-1.3
Impedance of leg (right)	0.3	1.6	7.5	-0.9	-1.2	-1.1	-2.7	-0.3	1.1	-0.9
Maternal smoking around birth	0.3	0.4	1.2	0.7	-1.1	-0.1	0.7	0.6	-0.7	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.7	-0.4	0.8	1.6	0.6	0.5	-0.6	0.7
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.1	-0.8	1.1	-0.4	0.9	0.3	-0.0	0.6
Father’s age at death	0.3	0.4	1.3	0.5	1.1	0.9	0.8	0.3	-0.3	-0.1
Happiness	0.3	0.3	0.7	0.2	0.9	-0.1	0.3	0.6	0.8	-0.7
Medication: Cholesterol lowering	0.3	0.4	1.3	-0.2	1.1	0.7	0.8	-0.2	-0.4	0.7
Impedance of arm (left)	0.3	1.3	4.1	0.3	0.7	-0.5	-1.6	1.5	2.0	-0.7
Birth weight of first child	0.3	0.5	1.5	-0.4	-1.1	-1.0	-1.2	-0.0	0.6	-0.1
Glaucoma (self-reported)	0.3	0.4	1.8	0.1	-0.5	0.4	-1.4	0.1	-0.1	-0.9
High blood pressure (siblings)	0.3	0.4	1.0	0.0	-0.2	-0.3	0.9	-0.7	1.0	0.6
Age at first live birth	0.3	0.5	3.2	-0.5	1.8	-0.2	0.1	0.3	0.2	0.1
Pulse wave peak to peak time	0.3	0.4	2.0	0.5	-0.3	0.1	-0.5	1.4	-0.6	0.2
Medication for pain relief, constipation, heartburn	0.3	0.5	1.9	0.3	-0.5	-0.5	0.8	0.9	-0.3	1.4
Medication: Ibuprofen	0.3	0.4	1.3	-0.4	-1.1	-0.5	0.7	0.3	0.6	0.9
Medication: Omeprazole	0.3	0.3	0.7	0.2	-0.7	-0.8	-0.8	0.5	-0.3	-0.6
Overall health rating	0.3	0.7	1.7	0.8	-1.3	-0.3	1.0	-1.1	-0.8	0.1
Hypertension (Self-reported)	0.3	0.9	2.1	0.6	0.8	1.0	0.5	-1.3	-1.1	1.4
Illnesses of siblings: Diabetes	0.3	0.3	0.9	-0.8	0.4	0.5	-0.5	-0.9	0.2	-0.5
Commuting to job workplace: Walk	0.3	0.3	0.9	-0.3	0.6	0.4	-0.5	-1.0	-0.1	-0.9
Smoking status: Current	0.3	0.5	1.9	0.5	-1.4	0.2	-1.3	0.3	-0.7	-0.2
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.5	0.4	1.1	0.6	0.5	-1.2	-0.1	0.0
Number of operations (self-reported)	0.3	0.4	1.9	-0.2	0.8	-0.3	0.8	-0.1	-0.2	-1.4
Average weekly beer plus cider intake	0.3	0.4	1.1	0.4	-0.7	-1.1	0.1	-1.0	-0.6	0.6
Reaction Time	0.2	0.4	1.9	-0.6	0.3	0.4	0.4	-0.7	0.5	-1.4
Blood Platelet Count	0.2	1.8	5.4	1.6	-2.2	-0.8	-2.3	0.1	-1.1	-0.5
Blood White Count	0.2	1.7	5.2	1.2	-0.6	0.9	-1.7	-2.3	-1.8	0.1
Heel T-Score	0.2	1.3	3.3	1.0	-0.8	1.6	-0.2	1.5	-1.8	-0.7
Lung FEV1/FVC ratio	0.2	1.1	4.5	0.6	0.3	1.0	-0.6	-2.1	-0.2	-1.5
Number of treatments/medications taken	0.2	0.4	1.5	0.7	1.2	0.3	0.4	-0.7	-0.9	0.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.5	0.6	-0.2	0.7	-0.1	0.5	-0.1	-0.5
Age when periods started (menarche)	0.2	0.4	1.7	0.4	0.1	0.3	-0.2	0.9	-1.3	0.4
Had menopause	0.2	0.2	0.7	-0.5	-0.6	-0.8	0.3	-0.2	0.6	-0.1
Medication: Ramipril	0.2	0.3	0.7	-0.8	-0.1	-0.7	-0.8	-0.3	0.5	-0.2
Medication: Simvastatin	0.2	0.2	0.7	0.2	0.2	0.4	0.7	-0.8	-0.7	-0.1
Alcohol intake versus 10 years previously	0.2	0.4	2.2	0.5	-0.4	-1.5	-0.1	0.4	0.1	-0.2
Worrier / anxious feelings	0.2	0.5	1.5	0.8	-0.1	0.2	-1.2	0.2	-0.5	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.5	-0.4	1.2	0.2	-0.4	0.0	-0.4	0.4
Length of working week for main job	0.2	0.2	1.4	0.1	-0.0	1.2	-0.0	-0.4	0.3	-0.2
Pulse wave reflection index	0.2	0.2	0.9	-0.8	-0.2	-0.2	0.4	-1.0	0.3	0.3
Worry too long after embarrassment	0.2	0.4	0.8	-0.7	-0.1	0.9	0.5	0.9	0.7	0.0
Number of children fathered	0.2	0.2	0.7	-0.6	-0.8	0.3	-0.1	-0.4	-0.2	-0.2
Mean time to correctly identify matches	0.2	0.3	1.1	0.3	-0.0	-0.7	0.3	-1.0	0.2	-0.7
Knee pain experienced in last month	0.2	0.4	1.1	-0.9	-0.4	-0.3	-0.6	-1.1	0.7	-0.1
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.6	0.8	-0.4	-0.7	0.1	0.7	-0.1	0.1
Eye problems/disorders: Glaucoma	0.2	0.3	1.4	0.0	-0.7	-0.4	-1.2	0.1	-0.1	-0.3
Impedance of whole body	0.2	1.2	5.2	-0.2	0.4	-0.8	-2.3	0.5	1.6	-1.0
Fasting Glucose	0.1	0.1	0.6	0.1	-0.2	-0.8	-0.2	-0.0	-0.3	-0.4
Blood Eosinophil Count	0.1	0.8	2.7	1.6	-0.3	0.6	-0.8	0.5	-1.5	-0.2
Cardiovascular Disease	0.1	0.5	1.6	0.5	-0.2	0.7	0.7	-0.5	-0.8	1.2
Tanning	0.1	1.0	5.9	0.3	-0.6	-2.4	0.4	0.7	-0.3	0.8
Ever had hysterectomy (womb removed)	0.1	0.1	0.4	-0.6	0.5	0.1	0.3	0.2	-0.1	-0.1
Sitting height	0.1	0.8	2.0	0.2	0.7	1.2	-0.3	-1.2	1.1	-1.4
Loud music exposure frequency	0.1	0.1	0.8	-0.3	-0.2	0.2	-0.9	-0.0	-0.2	-0.3
Medication: Paracetamol	0.1	0.2	0.7	0.8	-0.4	0.2	-0.2	-0.3	-0.1	-0.5
Leg pain on walking	0.1	0.2	0.6	0.8	-0.7	0.2	0.4	0.3	-0.4	0.1
Medication: Blood pressure	0.1	0.3	0.6	-0.1	0.8	0.4	0.6	-0.8	-0.6	0.1
Blood Red Count	0.0	0.4	1.1	0.2	-0.9	-0.1	-1.1	-0.1	-1.0	-0.6
Hair Pigment	0.0	0.5	1.1	-1.1	0.0	0.5	-0.7	-0.2	1.0	-1.1

Hub : Genes

PELI2

Models

Trait associations