Hub : Genes

SAMD4A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.122	0.0480	6.4e-03	0.003	NA	-0.003	NA	-0.001	2.0e-01	NA	6.4e-01	NA	3.7e-01
2	YFS	Blood	0.019	0.0076	1.4e-03	0.005	0.009	0.006	0.01	0.009	5.3e-03	5.2e-04	3.7e-03	0.00027	3.9e-04
3	TCGA	Thyroid Carcinoma	0.220	0.0560	4.8e-05	0.092	0.079	0.127	NA	0.126	3.0e-09	4.1e-08	2.4e-12	NA	2.8e-12

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.5	0.8	1.4	-1.0	0.0	-1.2
Bipolar Disorder or Schizophrenia	0.7	1.7	4.6	-2.1	0.7	-0.2
Depressed Affect (Nagel 2018)	2.1	4.5	12.1	-0.2	1.1	-3.5
Depression (Nagel 2018)	1.2	1.8	3.5	0.5	1.3	-1.9
Intelligence (Savage-Jansen 2018)	0.4	1.2	1.5	-1.2	0.8	1.2
Neuroticism (Nagel 2018)	1.3	3.0	7.9	-0.4	0.9	-2.8
Schizophrenia (2018)	0.8	1.6	3.7	-1.9	0.9	0.7
Schizophrenia vs Biploar Disorder	1.7	2.3	2.5	-1.5	1.6	1.5
Worry (Nagel 2018)	1.0	2.1	2.8	-1.3	1.3	-1.7
Alzheimer’s Disease (in mother)	0.3	0.4	0.9	0.3	-0.9	-0.2
Alzheimer’s Disease (in father)	0.8	0.9	1.9	0.7	-0.6	-1.4
Alzheimer’s Disease (including proxy)	0.4	0.6	1.5	0.1	-0.5	-1.2
Crohns Disease (2017)	0.7	1.6	2.6	0.9	-1.6	-1.1
Irritable Bowel Disease (IBD)	0.5	1.2	1.9	-0.1	-1.3	-1.4
Ulcerative Colitis (UC)	0.5	0.9	2.0	-1.4	-0.2	-0.8
Major Depression (MDD)	0.5	0.6	1.6	1.3	-0.4	0.3
Reaction Time	1.4	2.6	7.0	-0.1	0.9	2.6
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.7	-0.6	-0.5	0.8
Breast Cancer	0.1	0.2	0.2	0.3	-0.5	-0.4
Ovarian Cancer	0.2	0.2	0.7	0.1	-0.8	-0.1
Prostate Cancer	0.4	0.5	1.5	-0.1	-0.3	-1.2
Age at First Birth	0.2	0.2	0.7	0.8	0.0	0.2
Bipolar Disorder (2011)	0.3	0.3	0.8	-0.9	0.3	0.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.4	-0.3	-0.6	-0.3
Coronary Artery Disease (CAD)	0.1	0.2	0.2	0.5	-0.4	0.4
Crohns Disease (2012)	0.3	0.4	0.5	0.6	-0.7	-0.6
Mean Putamen Volume	0.3	0.3	0.9	1.0	-0.2	0.2
Fasting Glucose	1.0	1.2	2.5	1.6	0.4	-1.0
HbA1C	0.5	0.5	0.8	-0.7	-0.4	0.9
HDL Cholesterol	0.4	0.6	1.2	-0.3	-1.1	0.7
LDL Cholesterol	0.3	0.5	0.7	0.8	0.6	0.8
Lupus	0.3	0.5	1.1	-0.3	1.0	-0.5
Neuroticism (2016)	0.8	1.1	2.9	-0.5	-0.5	-1.7
Primary Biliary Cirrhosis	0.6	0.8	1.3	-0.8	1.2	0.7
Rheumatoid Arthritis	1.7	2.3	3.5	-1.9	1.8	0.4
Schizophrenia (2014)	0.9	2.0	4.8	-2.2	1.1	0.2
Triglycerides	2.0	3.3	8.1	-0.1	2.8	1.3
Type 2 Diabetes (T2D) (2012)	0.9	1.1	1.9	-1.4	1.1	0.4
Ulcerative Colitis	1.3	1.9	2.9	-1.7	1.3	-1.1
Blood Eosinophil Count	0.6	4.4	10.1	1.6	3.2	-0.8
Blood Platelet Count	0.8	9.5	26.4	-0.3	5.1	-1.4
Blood Red Count	0.2	2.4	6.3	0.9	2.5	0.1
Blood White Count	0.8	6.2	15.1	3.9	-1.5	-1.1
Heel T-Score	0.1	0.8	1.9	1.4	-0.5	0.6
BMI	0.7	4.3	8.8	1.5	-3.0	1.4
Height	2.3	44.5	96.8	-6.1	9.8	-0.3
Waist Hip Ratio (WHR)	0.4	1.8	3.5	-1.9	1.4	0.2
Systolic Blood Pressure	0.3	1.4	3.3	1.8	0.7	0.5
Smoking Status	0.8	1.8	5.3	-0.1	-0.3	-2.3
Allergy or Eczema	0.2	0.5	1.4	-0.2	0.1	-1.2
Cardiovascular Disease	0.0	0.1	0.2	-0.3	0.0	-0.5
Hypothyroidism (self reported)	0.2	0.4	0.7	0.5	0.4	-0.8
Respiratory disease	0.7	1.5	2.2	-1.5	1.0	-1.2
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.5	-0.5	1.6	1.0
Lung FEV1/FVC ratio	0.9	4.4	13.0	-0.5	3.6	-0.0
Lung FVC	2.2	11.3	31.5	1.4	-5.6	0.6
Neuroticism	1.8	4.5	7.1	-1.2	2.2	-2.7
Chronotype (morning person)	0.1	0.3	0.7	0.6	0.8	-0.1
Hair Pigment	0.0	0.4	0.6	-0.8	-0.7	-0.2
Tanning	0.3	3.4	5.5	2.1	-2.3	-0.6
Hand grip strength (left)	0.6	1.6	2.5	1.6	-1.5	0.2
Number of treatments/medications taken	0.1	0.1	0.2	-0.5	0.2	-0.1
Average weekly spirits intake	1.4	1.7	4.6	-0.8	-2.1	0.1
Sensitivity / hurt feelings	0.8	1.4	2.4	-1.4	0.3	-1.6
Frequency of depressed mood in last 2 weeks	2.2	3.0	7.9	0.8	0.7	-2.8
Hearing difficulty/problems: Yes	0.2	0.3	0.7	-0.4	0.0	-0.9
Relative age of first facial hair	0.2	0.3	0.5	-0.1	0.7	0.7
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.6	0.7	-0.8	-1.3
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.4	0.6	-0.2	0.5
Ever had hysterectomy (womb removed)	0.9	1.0	2.8	-0.4	-0.1	-1.7
Systolic blood pressure, automated reading	0.2	0.5	0.9	0.6	-0.4	0.9
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.3	-0.3	-1.1	1.0
Angina	1.1	1.5	4.1	-0.5	2.0	-0.2
Medication for hormone replacement therapy	1.3	1.5	2.5	1.2	-1.6	0.7
Vitamin and mineral supplements	1.3	1.8	5.3	2.3	0.2	0.4
Supplements: Zinc	0.8	0.9	2.6	-0.3	-0.0	-1.6
Medication: Co-codamol	0.2	0.2	0.6	-0.8	0.1	-0.3
Medication: Metformin	0.1	0.2	0.3	0.5	0.1	0.5
Diabetes (father)	0.4	0.5	1.0	-0.1	1.0	-0.6
Diabetes (mother)	1.7	2.2	4.6	-2.2	1.1	0.9
Severe depression (siblings)	0.5	0.6	1.4	-0.6	-0.3	-1.2
Pack years adult smoking proportion	1.1	1.6	4.0	2.0	0.5	-0.8
Impedance of leg (right)	0.3	1.2	2.5	-1.1	1.6	-0.1
Leg fat-free mass (left)	0.1	0.7	1.8	-0.5	1.4	0.2
Trunk fat percentage	0.4	1.5	3.6	-0.9	0.0	1.9
Hand grip strength (right)	0.1	0.2	0.5	0.1	-0.1	0.7
Townsend deprivation index at recruitment	0.5	0.7	1.6	-0.6	-0.3	1.2
Current tobacco smoking	1.6	2.5	6.8	0.9	0.0	-2.6
Average weekly fortified wine intake	0.2	0.2	0.7	0.8	0.2	-0.1
Maternal smoking around birth	0.9	1.3	3.4	1.9	0.2	-0.6
Fed-up feelings	1.7	3.1	8.9	-0.4	0.5	-3.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	4.3	0.4	1.0	-2.1
Relative age voice broke	0.5	0.8	1.0	0.4	1.0	1.0
Taking other prescription medications	0.2	0.2	0.3	-0.4	-0.5	-0.6
Age when periods started (menarche)	0.4	1.0	1.3	-1.0	0.8	-1.2
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	1.8	1.2	1.1	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.6	5.8	2.4	-0.8	1.2
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	1.7	-1.3	-0.1	1.0
Qualifications: CSEs or equivalent	0.1	0.2	0.3	-0.6	0.1	-0.4
Serious illness, injury or assault to yourself	1.2	1.4	3.0	0.7	-1.7	-0.9
High blood pressure	0.1	0.3	0.7	0.1	-0.9	0.1
Hayfever, allergic rhinitis or eczema	0.4	1.0	1.6	0.1	1.1	-1.3
Multivitamins +/- minerals	1.2	1.6	4.7	-2.2	0.1	0.2
Stomach or abdominal pain in last month	0.0	0.0	0.1	-0.1	0.2	-0.3
Supplements: Glucosamine	2.0	2.6	4.8	-2.2	-1.5	0.8
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.1	-0.2	0.6	1.0
Medication: Atenolol	0.2	0.2	0.5	0.7	-0.2	0.2
Medication: Levothyroxine sodium	0.4	0.6	1.1	0.2	0.9	1.0
Sitting height	1.8	12.8	28.0	-2.5	5.3	-2.0
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.2	0.3	-0.5
High blood pressure (mother)	0.3	0.5	1.0	0.5	-1.0	-0.3
Body mass index (BMI)	1.1	4.9	8.5	2.0	-2.9	1.5
Impedance of leg (left)	0.2	0.8	1.4	-1.0	1.2	0.2
Leg predicted mass (left)	0.1	0.7	1.9	-0.5	1.4	0.3
Trunk fat mass	0.3	1.1	2.2	-1.0	0.4	1.5
Waist circumference	0.5	1.8	5.4	0.1	-0.3	2.3
Number of incorrect matches in round	0.6	0.9	2.6	-0.4	-0.2	1.6
Past tobacco smoking	0.5	0.9	2.0	0.5	1.4	0.8
Alcohol usually taken with meals	0.1	0.2	0.6	0.2	0.8	0.0
Nervous feelings	1.5	2.7	4.2	-2.0	2.0	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.4	0.5	-0.6	-1.2
Hearing difficulty/problems with background noise	1.3	2.1	4.4	-1.4	-0.0	-2.1
Hair/balding pattern: Pattern 2	0.6	0.8	1.8	0.7	-1.3	-0.3
Had menopause	1.5	1.9	4.8	-2.2	0.8	0.5
Had other major operations	0.9	1.1	2.4	0.4	0.8	-1.5
Forced vital capacity (FVC)	0.1	0.3	0.8	-0.9	0.3	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	3.3	1.7	-0.9	1.8
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.2	1.1	-0.9	-1.0
Qualifications: None of the above	0.3	0.7	1.5	1.2	-0.7	-0.2
Financial difficulties in last 2 years	1.9	2.5	3.2	1.6	-1.8	-1.3
Mouth/teeth dental problems	0.2	0.2	0.6	0.7	-0.2	0.3
Heart attack	0.9	1.1	2.6	0.1	-0.8	1.6
Allergy	0.9	2.2	3.8	0.0	-2.0	1.6
Pain all over the body in last month	0.3	0.3	0.7	-0.1	-0.3	-0.9
Diabetes (self-reported)	0.6	0.9	2.2	0.0	0.7	1.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.4	0.6	0.3	-0.7
Medication: Ramipril	0.5	0.6	1.4	1.2	0.3	0.5
Medication: Simvastatin	0.6	0.9	1.5	-1.1	-0.3	1.2
Fluid intelligence score	0.6	1.2	2.5	-1.6	1.1	-0.3
Illnesses of siblings	0.2	0.3	0.4	0.5	-0.6	-0.4
Neuroticism score	1.2	2.5	6.0	-0.6	1.0	-2.5
Weight	0.1	0.4	1.0	-0.3	0.5	1.0
Impedance of arm (right)	1.8	8.3	15.1	-3.1	3.9	-0.1
Arm fat percentage (right)	0.5	2.0	3.4	0.6	-1.9	1.4
Trunk fat-free mass	0.1	0.7	1.7	0.2	1.3	-0.6
Hip circumference	0.2	0.8	2.2	0.5	0.1	1.5
Time employed in main current job	0.4	0.5	1.0	0.5	-0.3	-1.0
Alcohol intake versus 10 years previously	2.6	3.9	7.3	2.1	-2.7	-0.3
Father’s age at death	0.4	0.5	1.3	-1.2	0.1	0.4
Worrier / anxious feelings	0.7	1.3	3.8	-0.4	-0.1	-2.0
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.5	5.7	0.2	1.3	-2.4
Falls in the last year	0.6	0.8	2.0	-0.2	-1.4	0.6
Hair/balding pattern: Pattern 3	0.3	0.4	1.1	-1.1	0.3	0.1
Number of live births	1.0	1.4	4.1	0.2	-0.3	-2.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.6	-1.2	1.2	0.1
Pulse rate	0.7	1.1	1.4	-0.8	-1.2	1.2
Happiness	0.9	1.1	2.5	-0.5	0.7	-1.6
Noisy workplace	1.4	1.7	2.7	1.5	-1.6	0.5
Qualifications: A levels/AS levels or equivalent	0.7	1.6	4.3	-0.7	2.1	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.9	-0.9	-0.4	0.3
Mouth/teeth dental problems: Dentures	0.5	0.9	2.5	0.1	-0.3	1.6
Asthma	0.9	1.7	3.6	-0.7	1.0	-1.9
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.7	-0.1	0.7	0.8
Medication: Cholesterol lowering	0.3	0.4	1.0	-0.4	-0.3	1.0
Depression (self-reported)	1.4	1.7	4.2	-0.8	0.6	-2.0
Medication: Lansoprazole	0.7	0.8	1.3	0.6	-1.1	0.9
Prospective memory result	1.7	2.1	4.1	2.0	-0.4	1.4
Lung cancer (father)	0.1	0.1	0.2	-0.5	-0.2	-0.4
Illnesses of mother	0.3	0.4	1.1	-0.3	1.1	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	3.6	-1.9	0.7	-0.2
Pulse wave Arterial Stiffness index	0.8	1.0	2.6	0.5	0.1	1.6
Impedance of arm (left)	2.4	11.1	20.1	-3.6	4.5	0.2
Arm fat mass (right)	0.2	1.0	1.8	0.3	-1.3	1.0
Trunk predicted mass	0.1	0.7	1.7	0.3	1.3	-0.5
Standing height	2.4	23.9	50.9	-4.5	7.1	-1.0
Length of working week for main job	0.0	0.0	0.0	0.2	-0.1	-0.1
Exposure to tobacco smoke at home	0.3	0.3	0.4	0.7	0.3	0.7
Breastfed as a baby	1.0	1.3	3.6	-1.9	-0.3	-0.3
Tense / ‘highly strung’	0.5	0.8	2.0	-0.5	-0.3	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.4	-0.1	-0.5	-1.5
Hair/balding pattern: Pattern 4	0.3	0.7	1.6	0.7	1.3	0.4
Birth weight of first child	2.6	4.7	7.1	-2.3	1.4	2.7
Peak expiratory flow (PEF)	0.9	2.2	3.3	-1.8	1.4	-1.1
Pulse wave reflection index	0.3	0.4	0.6	0.4	0.8	0.6
Ever highly irritable/argumentative for 2 days	0.5	0.5	1.0	0.2	-1.0	-0.8
Loud music exposure frequency	2.0	2.2	3.4	-1.4	1.8	-1.0
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.1	0.0	1.8	0.5
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	3.1	-1.8	0.0	0.0
Blood clot in the leg (DVT)	0.3	0.4	1.1	-1.0	0.0	0.4
Medication: Paracetamol	2.0	3.4	7.8	1.0	-1.1	-2.8
Headache pain in last month	0.3	0.5	0.7	-0.9	-0.8	-0.4
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.1	0.4	0.2	-0.4
Glaucoma (self-reported)	0.5	0.6	1.1	0.6	0.6	1.0
Gout (self-reported)	0.5	0.6	1.0	0.9	0.3	1.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.0	1.0	0.5	0.3
Medication: Amlodipine	1.4	1.9	5.8	-0.0	0.0	2.4
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.3	0.6	-0.6	0.5
Birth weight	0.4	0.9	1.2	-1.0	-0.8	-1.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.5	1.2	-0.8	-0.0
High blood pressure (siblings)	0.0	0.0	0.1	0.2	0.2	-0.2
Forced vital capacity (FVC), Best measure	0.5	1.8	5.0	-2.2	0.1	-0.7
Body fat percentage	0.4	1.7	3.8	-0.1	-1.1	1.9
Leg fat percentage (right)	1.1	3.9	6.9	1.7	-2.6	1.4
Arm fat-free mass (right)	0.0	0.1	0.2	0.3	0.5	0.1
Exposure to tobacco smoke outside home	0.2	0.3	0.6	-0.6	0.2	-0.8
Comparative body size at age 10	0.8	2.2	4.0	0.1	-2.0	1.6
Number of full brothers	1.1	1.3	3.4	0.7	-1.8	-0.2
Worry too long after embarrassment	0.2	0.3	0.5	-0.7	-0.3	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.3	1.1	-0.8	-0.7
Wheeze or whistling in the chest in last year	0.6	1.1	2.2	0.9	0.4	-1.5
Number of children fathered	1.7	1.9	4.3	0.5	-2.1	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.8	1.2	-1.1	-0.1	1.0
Age at first live birth	1.7	3.0	5.4	-2.3	1.3	-1.4
Pulse wave peak to peak time	1.2	1.4	3.3	-0.8	0.4	-1.8
Health satisfaction	0.9	1.2	1.8	-0.1	-1.3	-1.3
Shortness of breath walking on level ground	0.1	0.1	0.2	0.4	0.3	-0.1
Qualifications: College or University degree	0.4	1.1	3.0	-0.5	1.7	0.5
Eye problems/disorders: None of the above	1.2	1.4	3.0	0.7	-0.8	-1.7
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.1	0.3	-0.2	-0.1
Emphysema/chronic bronchitis	0.5	0.6	0.9	0.7	0.9	-0.6
Medication for pain relief, constipation, heartburn	0.2	0.3	0.4	-0.4	0.5	0.6
Neck or shoulder pain in last month	0.7	0.9	2.8	-0.3	-0.1	-1.7
Medication: Blood pressure	0.0	0.1	0.1	0.3	0.0	0.3
Angina (self-reported)	1.1	1.4	3.7	-0.7	1.9	-0.1
Migraine (self-reported)	0.5	0.7	1.5	-1.2	0.2	-0.6
Medication: Ibuprofen	0.9	1.0	1.5	-0.4	1.2	1.2
Medication: Allopurinol	0.0	0.1	0.1	0.1	0.4	0.2
Medication: Omeprazole	0.2	0.2	0.5	-0.7	-0.2	0.1
Medication: Seretide 50 evohaler	0.1	0.1	0.2	-0.5	-0.3	0.3
Mean time to correctly identify matches	1.6	3.1	9.1	0.2	-0.3	3.0
Heart disease (mother)	0.3	0.4	1.0	0.0	-1.0	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.4	0.2	-0.2	1.2
Whole body fat mass	0.2	0.8	2.1	-0.3	-0.5	1.5
Leg fat mass (right)	0.4	1.5	2.4	0.8	-1.5	1.2
Arm predicted mass (right)	0.0	0.2	0.5	0.2	0.7	0.0
Pulse rate, automated reading	0.5	1.7	4.5	-0.8	-2.1	0.0
Alcohol intake frequency.	0.4	0.9	2.0	1.4	-0.4	-0.7
Comparative height size at age 10	1.4	7.5	14.9	-2.6	3.9	-1.0
Number of full sisters	1.2	1.4	2.6	1.6	-1.3	0.3
Suffer from ‘nerves’	1.1	1.7	2.9	-1.7	1.5	0.1
Overall health rating	0.9	2.0	5.1	0.5	-0.8	-2.3
Chest pain or discomfort	0.5	0.8	0.9	0.7	0.9	-1.0
Had major operations	0.1	0.1	0.2	0.4	-0.2	-0.2
Age at last live birth	1.5	2.2	3.0	-1.6	1.0	-1.7
Family relationship satisfaction	0.2	0.3	0.4	-0.5	-0.4	0.6
Leg pain on walking	0.1	0.1	0.3	0.1	-0.5	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	2.0	-0.6	-1.4	-0.0
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.3	-0.3	0.4	-0.5
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	2.4	-1.0	1.6	0.7
Medication: Aspirin	0.3	0.3	0.8	0.2	-0.4	0.9
Supplements: Vitamin C	1.4	1.6	1.9	-1.4	1.1	-1.3
Knee pain experienced in last month	1.8	2.7	4.4	0.1	-2.1	1.9
Hypertension (Self-reported)	0.1	0.2	0.3	0.6	-0.5	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	5.0	2.2	-0.1	-0.2
Illnesses of father: Heart disease	3.3	4.6	9.8	-1.1	1.6	3.1
Illnesses of siblings: Diabetes	1.0	1.3	3.4	1.9	0.1	0.6
Smoking status: Previous	0.3	0.4	0.8	-0.5	-0.9	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.1	7.6	-2.1	2.8	-0.4
Whole body fat-free mass	0.1	0.5	1.3	0.1	1.1	-0.3
Leg fat-free mass (right)	0.2	0.9	2.3	-0.6	1.5	0.4
Arm fat percentage (left)	0.4	1.6	2.5	0.5	-1.6	1.4
Average weekly red wine intake	0.1	0.2	0.2	-0.5	-0.5	0.4
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.7	0.9	-0.4	-0.1
Mood swings	1.6	2.9	6.1	-1.4	0.8	-2.5
Loneliness, isolation	2.4	3.4	6.3	-1.3	1.4	-2.5
Long-standing illness, disability or infirmity	0.1	0.2	0.6	0.8	-0.1	-0.2
Ever had bowel cancer screening	0.5	0.6	1.0	-1.0	-0.2	0.8
Diabetes diagnosed by doctor	0.3	0.5	0.9	0.2	0.7	1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	2.4	1.2	-0.9	-1.5
Friendships satisfaction	0.5	0.6	1.0	-1.0	0.4	0.8
Qualifications: nursing, teaching	0.3	0.4	1.0	1.0	0.2	0.5
Commuting to job workplace: Walk	0.1	0.1	0.1	0.3	-0.4	0.1
Eye problems/disorders: Cataract	2.2	2.6	7.2	0.1	0.7	2.7
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.7	-0.8	0.3	-1.3
Medication for cholesterol	0.4	0.6	1.4	-0.5	1.2	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	5.8	-0.1	2.4	-0.5
Back pain experienced in last month	2.1	3.0	6.1	0.1	-1.7	-2.5
Mineral and other dietary supplements	0.9	1.2	3.3	1.8	0.5	0.4
Breast cancer (self-reported)	0.5	0.6	1.1	0.8	1.1	-0.3
Asthma (self-reported)	0.7	1.4	3.0	-0.5	1.0	-1.7
Osteoporosis (self-reported)	1.7	2.1	4.5	-2.1	1.2	-0.7
Osteoarthritis (self-reported)	0.1	0.2	0.4	-0.7	0.0	-0.2
Medication: Aspirin	0.3	0.4	1.2	-0.1	0.1	1.1
Medication: Gliclazide	2.1	2.4	5.3	-0.3	1.3	2.3
Illnesses of father: None of the above (group 1)	2.4	3.0	6.3	2.5	-1.4	-0.9
Smoking status: Current	1.8	2.9	7.8	0.9	-0.2	-2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.2	-0.5	-0.4	0.4
Whole body water mass	0.1	0.3	1.0	0.1	1.0	-0.2
Leg predicted mass (right)	0.2	0.9	2.0	-0.6	1.4	0.5
Arm fat mass (left)	0.2	0.9	1.3	0.4	-1.1	1.1
Number of self-reported non-cancer illnesses	0.5	0.9	1.6	-1.3	0.6	-0.9
Average weekly champagne plus white wine intake	0.0	0.1	0.1	0.2	0.3	-0.2
Miserableness	0.9	1.6	3.0	1.7	-0.1	-1.4
Guilty feelings	0.7	1.0	1.5	0.5	-1.2	-1.2
Wears glasses or contact lenses	0.3	0.4	0.9	0.1	0.3	1.0
Ever taken oral contraceptive pill	0.2	0.2	0.4	0.4	0.2	-0.7
Hearing aid user	0.6	0.7	1.3	-0.7	-0.4	-1.2
Mother’s age at death	0.9	1.1	1.8	0.8	-1.0	1.4
Financial situation satisfaction	1.5	1.9	4.8	1.0	0.1	-2.2
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.0	0.7	0.3	1.4
Commuting to job workplace: Public transport	2.0	2.4	7.1	-0.2	0.4	2.7
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.4	0.3	0.1
Medication: Blood pressure	0.0	0.1	0.2	0.4	-0.1	-0.3
Pain type(s) experienced in last month: Hip pain	1.1	1.3	2.8	0.7	-1.7	0.9
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.2	-1.1	-0.5	-0.1
High cholesterol (Self-reported)	0.8	1.4	4.2	-2.1	-0.4	-0.0
Medication: Bendroflumethiazide	0.5	0.7	1.6	-0.1	-0.8	-1.3
Medication: Paracetamol	2.6	4.0	10.2	0.5	-1.2	-3.2
Medication: Lisinopril	0.1	0.1	0.3	-0.5	-0.1	0.3
Medication: Atorvastatin	0.2	0.2	0.5	0.3	0.7	-0.3
Illnesses of father: High blood pressure	1.3	1.6	4.2	-2.1	0.8	0.2
Alcohol drinker status: Never	3.5	4.2	9.1	3.0	-1.8	0.1
Ever smoked	0.8	1.4	2.8	-0.7	-1.7	-1.0
Basal metabolic rate	0.1	0.3	1.0	-0.0	1.0	0.1
Leg fat percentage (left)	1.4	5.0	9.2	1.7	-3.0	1.7
Arm fat-free mass (left)	0.0	0.2	0.3	0.4	0.2	0.5
Number of operations (self-reported)	1.3	2.0	5.8	0.5	0.1	-2.4
Average weekly beer plus cider intake	0.5	0.7	2.0	1.4	-0.4	0.1
Irritability	0.4	0.7	1.7	1.3	-0.1	-0.6
Risk taking	0.7	1.0	2.4	-0.5	-1.6	0.5
Ever had prostate specific antigen (PSA) test	0.8	1.0	1.4	-1.2	-1.0	-0.7
Fractured/broken bones in last 5 years	0.8	1.0	2.5	-1.6	-0.2	0.6
Age started oral contraceptive pill	0.6	0.7	1.6	-0.6	-0.4	1.3
Diastolic blood pressure, automated reading	0.2	0.6	1.3	0.0	-1.1	-0.7
Ever depressed for a whole week	0.2	0.2	0.6	0.1	-0.1	-0.8
Unable to work because of sickness or disability	0.6	0.8	1.0	0.8	-1.0	0.8
Commuting to job workplace: Cycle	0.3	0.3	0.5	0.7	-0.6	-0.4
Myopia	2.2	3.2	4.7	1.6	-1.5	2.2
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.7	0.2	0.8	-0.1
Cholesterol lowering medication	0.4	0.6	1.1	-1.0	0.4	0.7
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.5	0.0	-1.9	0.1
Pain experienced in last month	0.7	1.1	1.8	0.9	1.3	0.9
Supplements: Calcium	3.9	4.3	7.8	-2.2	-0.1	-2.8
Basal cell carcinoma (self-reported)	1.3	1.5	4.5	0.0	-0.2	2.1
Heart attack/myocardial infarction (self-reported)	0.8	1.1	2.4	0.0	-0.8	1.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.6	-0.8	-0.1	0.7
Heart disease (siblings)	0.3	0.4	0.8	-0.7	0.2	0.9
Alcohol drinker status: Previous	0.7	0.8	1.8	-0.0	0.7	-1.3
Pack years of smoking	0.8	1.2	3.6	1.9	0.1	-0.2
Impedance of whole body	1.5	7.5	13.3	-3.0	3.6	0.2
Leg fat mass (left)	0.5	1.9	3.0	0.8	-1.7	1.4
Arm predicted mass (left)	0.0	0.2	0.4	0.6	0.2	0.3