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chr15:49,952,940-52,806,425

Best TWAS P=2.68e-45 · Best GWAS P=7.41e-44 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TNFAIP8L3	0.12	0.07	blup	462	0.09	1.2e-10	-12.864	-14.1	2.7e-45	0.29	1.00	0.00	TRUE
2	CommonMind	Brain Pre-frontal Cortex	TRPM7	0.06	0.03	bslmm	416	0.06	2.8e-08	6.074	8.1	6.3e-16	-0.06	0.94	0.01	FALSE
3	CommonMind	Brain Pre-frontal Cortex	USP8	0.07	0.00	bslmm	425	0.02	5.0e-04	5.565	-6.0	1.5e-09	0.09	0.08	0.18	TRUE
4	GTEx	Artery Aorta	SPPL2A	0.22	0.03	enet	39	0.11	1.2e-06	9.150	10.2	1.8e-24	-0.12	0.78	0.03	FALSE
5	GTEx	Artery Coronary	GLDN	0.14	0.00	lasso	6	0.00	2.7e-01	7.416	5.2	2.5e-07	-0.12	0.10	0.05	FALSE
6	GTEx	Artery Tibial	SPPL2A	0.12	0.05	enet	14	0.12	1.1e-09	9.129	6.2	4.8e-10	-0.01	0.98	0.00	FALSE
7	GTEx	Artery Tibial	GLDN	0.10	0.02	lasso	6	0.05	1.2e-04	-10.246	6.9	6.3e-12	0.14	0.51	0.04	TRUE
8	GTEx	Brain Cerebellar Hemisphere	TRPM7	0.28	0.06	enet	17	0.03	7.0e-02	-7.041	-8.0	1.3e-15	0.15	0.26	0.06	FALSE
9	GTEx	Brain Cerebellum	TRPM7	0.17	0.14	lasso	3	0.13	1.3e-04	-7.002	-7.0	1.8e-12	0.13	0.38	0.05	TRUE
10	GTEx	Brain Putamen basal ganglia	LYSMD2	0.18	0.04	lasso	4	0.01	1.4e-01	-8.572	-8.1	8.4e-16	0.66	0.07	0.24	FALSE
11	GTEx	Breast Mammary Tissue	RP11-707P17.2	0.10	0.02	lasso	4	0.00	1.9e-01	0.490	-5.6	2.3e-08	0.44	0.10	0.61	FALSE
12	GTEx	Breast Mammary Tissue (Male)	SPPL2A	0.36	-0.01	enet	13	0.09	4.3e-03	-3.992	6.2	6.4e-10	-0.05	0.07	0.05	FALSE
13	GTEx	Cells Transformed fibroblasts	AP4E1	0.11	0.00	enet	33	0.00	1.4e-01	9.136	8.1	6.7e-16	-0.05	0.18	0.03	TRUE
14	GTEx	Cells Transformed fibroblasts	SPPL2A	0.28	0.11	enet	23	0.31	9.9e-24	0.925	5.1	3.0e-07	-0.01	1.00	0.00	FALSE
15	GTEx	Colon Transverse	SPPL2A	0.11	0.00	enet	8	0.02	5.2e-02	-1.515	7.9	3.2e-15	0.02	0.09	0.05	FALSE
16	GTEx	Esophagus Mucosa	RP11-562A8.5	0.08	0.02	enet	7	0.05	2.4e-04	5.941	-5.9	3.2e-09	0.09	0.30	0.07	FALSE
17	GTEx	Esophagus Muscularis	SPPL2A	0.19	0.13	lasso	5	0.11	2.8e-07	6.232	6.0	1.6e-09	-0.07	1.00	0.00	FALSE
18	GTEx	Heart Atrial Appendage	SPPL2A	0.07	0.10	lasso	3	0.09	6.5e-05	6.232	5.5	4.3e-08	-0.05	0.40	0.03	FALSE
19	GTEx	Heart Left Ventricle	TNFAIP8L3	0.11	0.02	enet	12	0.01	1.4e-01	-8.572	-6.9	4.7e-12	0.80	0.04	0.71	TRUE
20	GTEx	Lung	SPPL2A	0.08	0.08	lasso	4	0.07	6.0e-06	9.465	10.0	1.8e-23	-0.11	0.77	0.01	FALSE
21	GTEx	Muscle Skeletal	AP4E1	0.17	0.08	lasso	9	0.11	9.1e-11	-9.868	-6.1	9.3e-10	0.20	1.00	0.00	FALSE
22	GTEx	Muscle Skeletal	TRPM7	0.08	0.05	lasso	7	0.07	4.4e-07	-7.002	-7.7	1.5e-14	0.19	0.79	0.17	FALSE
23	GTEx	Muscle Skeletal	SPPL2A	0.09	0.04	lasso	5	0.06	1.4e-06	6.193	5.6	1.8e-08	-0.05	0.98	0.00	FALSE
24	GTEx	Nerve Tibial	SPPL2A	0.12	0.10	lasso	4	0.09	4.8e-07	6.193	7.9	3.9e-15	-0.07	1.00	0.00	TRUE
25	GTEx	Nerve Tibial	GLDN	0.10	0.06	lasso	4	0.04	4.7e-04	-11.764	11.0	4.5e-28	-0.44	0.57	0.08	FALSE
26	GTEx	Pancreas	TMOD2	0.23	0.02	enet	36	0.03	1.3e-02	-0.095	5.4	8.2e-08	-0.14	0.11	0.08	FALSE
27	GTEx	Testis	USP8	0.16	0.12	lasso	2	0.10	3.4e-05	5.884	6.3	2.2e-10	-0.11	0.53	0.04	TRUE
28	GTEx	Vagina	CTD-3110H11.1	0.61	0.34	enet	59	0.43	3.7e-11	0.277	5.8	5.1e-09	-0.09	0.90	0.02	TRUE
29	METSIM	Adipose	SPPL2A	0.11	0.03	blup	426	0.08	1.5e-12	1.475	6.0	2.3e-09	0.09	1.00	0.00	FALSE
30	METSIM	Adipose	TRPM7	0.05	0.00	blup	414	0.03	7.1e-05	7.717	5.8	5.8e-09	-0.19	0.10	0.25	FALSE
31	YFS	Blood	AP4E1	0.08	0.05	lasso	7	0.07	1.1e-22	2.740	6.7	2.9e-11	-0.22	1.00	0.00	FALSE
32	YFS	Blood	LYSMD2	0.07	0.00	blup	461	0.02	1.6e-06	-2.114	7.7	1.3e-14	-0.41	0.44	0.05	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	AP4E1	0.02	0.02	lasso	3	0.01	9.5e-04	9.465	9.9	4.0e-23	-0.11	0.59	0.01	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC100132724	0.02	0.01	lasso	3	0.01	1.6e-03	9.434	7.5	4.3e-14	-0.07	0.16	0.02	FALSE
35	The Cancer Genome Atlas	Colon Adenocarcinoma	SPPL2A	0.12	0.05	blup	39	0.04	2.6e-03	6.193	6.6	3.4e-11	-0.10	0.04	0.10	FALSE
36	The Cancer Genome Atlas	Esophageal Carcinoma	TRPM7	0.19	0.02	enet	14	0.06	7.3e-03	9.124	6.7	2.7e-11	-0.08	0.08	0.38	FALSE
37	The Cancer Genome Atlas	Glioblastoma Multiforme	SPPL2A	0.22	0.13	lasso	1	0.09	9.4e-04	6.229	6.2	4.7e-10	-0.08	0.03	0.05	FALSE
38	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GLDN	0.04	0.02	blup	108	0.01	2.1e-02	-4.753	-6.5	8.1e-11	0.36	0.16	0.09	FALSE
39	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	USP8	0.05	0.01	blup	59	0.02	1.8e-03	3.056	-6.2	5.1e-10	0.12	0.02	0.76	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AP4E1	0.04	0.01	enet	20	0.02	2.2e-03	10.694	11.9	1.2e-32	-0.22	0.01	0.85	TRUE
41	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TNFAIP8L3	0.03	0.00	blup	41	0.01	8.3e-03	7.717	10.6	4.3e-26	-0.28	0.01	0.28	FALSE
42	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	USP8	0.07	0.05	lasso	3	0.06	4.2e-04	5.917	-6.3	3.0e-10	0.11	0.14	0.44	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC100132724	0.03	0.01	blup	31	0.01	1.9e-02	10.634	11.1	2.1e-28	-0.14	0.07	0.07	FALSE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRPM7	0.03	0.04	lasso	1	0.03	9.2e-05	9.124	9.1	7.2e-20	-0.13	0.09	0.88	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	USP8	0.03	0.01	lasso	4	0.01	3.2e-02	5.080	-5.9	4.0e-09	0.09	0.06	0.13	FALSE
46	The Cancer Genome Atlas	Lung Adenocarcinoma	SPPL2A	0.07	0.06	lasso	2	0.05	9.3e-07	6.232	6.2	4.3e-10	-0.08	0.96	0.00	FALSE
47	The Cancer Genome Atlas	Lung Adenocarcinoma	USP8	0.02	0.02	enet	4	0.02	9.9e-04	6.116	-6.5	6.1e-11	0.10	0.06	0.77	FALSE
48	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	USP8	0.07	0.03	lasso	5	0.01	1.5e-01	-7.002	-6.7	1.7e-11	0.11	0.02	0.40	FALSE
49	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SPPL2A	0.43	0.35	enet	9	0.34	2.1e-14	6.193	6.6	3.2e-11	-0.07	1.00	0.00	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	AP4E1	0.09	0.01	enet	8	0.03	6.5e-04	-12.857	13.0	1.2e-38	-0.32	0.00	0.98	TRUE
51	The Cancer Genome Atlas	Prostate Adenocarcinoma	TRPM7	0.03	0.03	lasso	2	0.03	3.4e-04	-6.939	7.0	2.1e-12	-0.13	0.06	0.89	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	SPPL2A	0.25	0.17	blup	39	0.24	7.3e-23	6.229	5.7	1.2e-08	-0.03	1.00	0.00	FALSE
53	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	USP8	0.16	0.13	lasso	7	0.10	9.2e-04	5.693	-5.7	1.1e-08	0.13	0.09	0.17	FALSE