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chr17:3,587-2,918,626

Best TWAS P=2.55e-25 · Best GWAS P=1.36e-24 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SERPINF1	0.34	0.30	enet	24	0.34	2.2e-43	9.64	-9.4	6.2e-21	0.01	0.14	0.86	TRUE
2	CommonMind	Brain Pre-frontal Cortex	TLCD2	0.15	0.10	lasso	3	0.09	1.6e-10	8.48	9.2	3.4e-20	-0.48	1.00	0.00	TRUE
3	GTEx	Adipose Subcutaneous	SERPINF1	0.19	0.05	lasso	6	0.02	6.3e-03	9.92	-8.6	6.1e-18	0.01	0.04	0.79	FALSE
4	GTEx	Adipose Subcutaneous	SMYD4	0.20	0.14	lasso	2	0.16	2.6e-13	9.64	-9.9	2.7e-23	0.04	0.12	0.88	FALSE
5	GTEx	Artery Aorta	CRK	0.28	0.05	enet	41	0.05	9.0e-04	6.26	5.2	2.5e-07	0.06	0.85	0.01	FALSE
6	GTEx	Artery Tibial	CRK	0.19	0.14	lasso	6	0.18	3.5e-14	6.26	6.9	5.4e-12	0.03	1.00	0.00	FALSE
7	GTEx	Artery Tibial	SMYD4	0.20	0.18	enet	10	0.18	8.2e-14	9.65	-9.5	3.2e-21	0.05	0.26	0.74	FALSE
8	GTEx	Brain Cortex	SMYD4	0.34	0.17	lasso	4	0.23	5.3e-07	9.80	-8.5	2.2e-17	0.03	0.08	0.74	FALSE
9	GTEx	Cells Transformed fibroblasts	SERPINF1	0.20	0.11	lasso	3	0.16	5.6e-12	9.92	-9.6	5.5e-22	0.02	0.04	0.96	FALSE
10	GTEx	Cells Transformed fibroblasts	CRK	0.19	0.06	lasso	6	0.12	1.6e-09	6.26	8.2	3.4e-16	0.04	0.99	0.00	TRUE
11	GTEx	Cells Transformed fibroblasts	SMYD4	0.23	0.18	lasso	4	0.23	5.9e-17	9.65	-8.3	8.8e-17	0.09	0.23	0.77	FALSE
12	GTEx	Colon Sigmoid	SMYD4	0.33	0.24	lasso	7	0.24	5.0e-09	9.65	-9.9	2.8e-23	0.05	0.10	0.90	FALSE
13	GTEx	Colon Transverse	RP11-676J12.4	0.19	0.06	lasso	4	0.03	8.8e-03	5.40	-5.6	2.6e-08	0.05	0.01	0.96	TRUE
14	GTEx	Esophagus Gastroesophageal Junction	CRK	0.24	0.08	lasso	4	0.06	4.2e-03	6.39	6.7	2.8e-11	0.05	0.10	0.04	FALSE
15	GTEx	Esophagus Muscularis	CRK	0.20	0.20	enet	16	0.21	4.0e-13	6.26	6.6	4.5e-11	0.05	1.00	0.00	FALSE
16	GTEx	Esophagus Muscularis	SMYD4	0.24	0.16	lasso	3	0.18	3.1e-11	9.68	-10.0	1.6e-23	0.05	0.12	0.88	FALSE
17	GTEx	Lung	AC016292.3	0.11	0.01	enet	10	0.00	1.8e-01	-7.65	-7.2	7.9e-13	0.38	0.11	0.05	FALSE
18	GTEx	Lung	SERPINF2	0.19	0.06	enet	22	0.09	1.2e-07	-7.65	8.5	1.8e-17	-0.60	0.08	0.91	TRUE
19	GTEx	Lung	SMYD4	0.10	0.09	lasso	3	0.09	1.4e-07	9.65	-9.9	4.9e-23	0.04	0.12	0.88	FALSE
20	GTEx	Nerve Tibial	CRK	0.23	0.12	lasso	6	0.17	2.5e-12	6.39	7.0	3.8e-12	0.04	1.00	0.00	FALSE
21	GTEx	Nerve Tibial	SMYD4	0.23	0.14	lasso	4	0.17	3.2e-12	9.80	-10.2	2.9e-24	0.04	0.09	0.91	FALSE
22	GTEx	Pancreas	SERPINF1	0.31	0.08	enet	26	0.06	1.1e-03	-8.92	7.9	3.0e-15	-0.52	0.08	0.61	FALSE
23	GTEx	Pancreas	SERPINF2	0.39	0.29	lasso	1	0.28	1.8e-12	-8.92	8.9	4.5e-19	-0.83	0.27	0.73	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	SMYD4	0.28	0.06	enet	36	0.12	5.8e-07	9.85	-8.3	7.8e-17	-0.02	0.10	0.82	FALSE
25	GTEx	Skin Sun Exposed Lower leg	SMYD4	0.17	0.00	lasso	4	0.03	1.3e-03	-6.46	-6.5	1.1e-10	-0.03	0.09	0.85	FALSE
26	GTEx	Stomach	CRK	0.18	0.06	lasso	5	0.08	1.8e-04	-5.98	5.9	3.8e-09	0.02	0.58	0.03	FALSE
27	GTEx	Testis	SERPINF1	0.29	0.14	lasso	6	0.13	3.0e-06	-6.34	-5.8	4.8e-09	-0.05	0.45	0.15	FALSE
28	GTEx	Testis	VPS53	0.30	0.13	lasso	6	0.19	8.7e-09	-4.15	5.5	4.0e-08	0.01	0.42	0.49	FALSE
29	GTEx	Testis	SRR	0.13	0.12	lasso	2	0.09	6.6e-05	6.20	-5.9	2.8e-09	-0.01	0.01	0.98	FALSE
30	GTEx	Testis	SMYD4	0.24	0.09	enet	14	0.10	2.9e-05	9.89	-8.4	5.8e-17	0.01	0.06	0.86	FALSE
31	GTEx	Thyroid	YWHAE	0.10	0.01	lasso	5	0.01	4.9e-02	6.20	6.5	6.9e-11	0.01	0.23	0.04	FALSE
32	GTEx	Thyroid	CRK	0.12	0.05	enet	10	0.10	5.9e-08	5.46	6.0	2.7e-09	0.04	0.99	0.00	FALSE
33	GTEx	Thyroid	WDR81	0.15	0.03	lasso	7	0.03	1.7e-03	2.12	-6.3	2.1e-10	0.60	0.03	0.92	FALSE
34	GTEx	Thyroid	SMYD4	0.32	0.13	enet	11	0.23	1.5e-17	9.85	-10.3	9.5e-25	0.01	0.08	0.92	FALSE
35	METSIM	Adipose	SERPINF1	0.06	0.00	bslmm	450	0.02	2.5e-04	9.85	-8.7	3.1e-18	0.05	0.07	0.64	FALSE
36	NTR	Blood	SERPINF1	0.02	0.01	enet	12	0.02	5.2e-06	9.92	6.4	1.3e-10	0.13	0.07	0.90	FALSE
37	ROSMAP	Brain Pre-frontal Cortex	SMG6	0.10	0.03	blup	520	0.04	4.0e-06	-4.78	5.7	1.5e-08	-0.29	0.84	0.06	FALSE
38	ROSMAP	Brain Pre-frontal Cortex	CRK	0.08	0.08	lasso	7	0.07	1.3e-09	6.26	6.6	3.9e-11	0.02	1.00	0.00	FALSE
39	YFS	Blood	RPA1	0.05	0.02	bslmm	459	0.04	9.4e-12	5.08	5.7	1.6e-08	0.02	1.00	0.00	TRUE
40	YFS	Blood	SERPINF2	0.10	0.05	enet	16	0.07	3.1e-22	-7.65	7.9	3.0e-15	-0.69	0.91	0.09	FALSE
41	YFS	Blood	SMYD4	0.17	0.15	bslmm	436	0.18	1.2e-55	9.68	-9.1	9.7e-20	0.01	0.26	0.74	FALSE
42	YFS	Blood	WDR81	0.17	0.16	enet	22	0.18	1.3e-57	9.92	7.5	7.6e-14	0.16	0.03	0.97	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	C17orf91	0.05	0.03	blup	51	0.04	2.4e-08	7.25	-7.2	6.0e-13	0.32	1.00	0.00	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	SERPINF2	0.03	0.01	enet	6	0.02	2.9e-04	-7.65	6.5	1.1e-10	-0.62	0.08	0.82	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	SMYD4	0.04	0.04	lasso	6	0.04	3.7e-09	-3.19	-6.5	1.0e-10	0.11	0.70	0.30	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	WDR81	0.03	0.01	lasso	3	0.01	6.4e-03	-7.65	5.4	7.6e-08	-0.45	0.04	0.28	FALSE
47	The Cancer Genome Atlas	Esophageal Carcinoma	SRR	0.32	0.13	lasso	2	0.16	9.2e-06	6.20	-6.2	5.2e-10	-0.01	0.00	1.00	TRUE
48	The Cancer Genome Atlas	Glioblastoma Multiforme	SMYD4	0.20	0.10	lasso	6	0.20	1.3e-06	9.80	-10.4	2.6e-25	0.22	0.01	0.95	TRUE
49	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C17orf91	0.06	0.05	lasso	2	0.04	4.6e-05	8.47	-8.4	3.9e-17	0.40	0.89	0.00	FALSE
50	The Cancer Genome Atlas	Brain Lower Grade Glioma	C17orf91	0.07	0.06	lasso	6	0.06	4.7e-07	7.25	-5.9	3.5e-09	0.20	1.00	0.00	TRUE
51	The Cancer Genome Atlas	Brain Lower Grade Glioma	SERPINF2	0.09	0.05	enet	11	0.08	4.9e-09	0.18	6.5	8.6e-11	-0.43	0.89	0.07	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	SMYD4	0.12	0.10	lasso	7	0.14	1.2e-15	9.80	-8.8	1.5e-18	0.12	0.01	0.99	FALSE
53	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	OVCA2	0.16	0.00	blup	47	0.00	6.7e-01	-2.33	-5.2	2.6e-07	0.03	0.01	0.09	FALSE
54	The Cancer Genome Atlas	Lung Adenocarcinoma	SERPINF1	0.08	0.00	enet	13	0.03	4.2e-04	-10.24	6.5	9.8e-11	-0.73	0.00	0.97	FALSE
55	The Cancer Genome Atlas	Lung Adenocarcinoma	SERPINF2	0.13	0.09	lasso	4	0.10	1.9e-11	-9.00	10.4	3.9e-25	-0.92	0.00	1.00	TRUE
56	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SERPINF2	0.06	0.06	lasso	1	0.06	3.9e-07	-8.96	9.0	3.1e-19	-0.83	0.01	0.98	FALSE
57	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CRK	0.13	0.00	blup	49	0.05	3.7e-03	2.17	6.7	1.7e-11	0.07	0.02	0.43	FALSE
58	The Cancer Genome Atlas	Prostate Adenocarcinoma	C17orf91	0.08	0.05	enet	13	0.04	2.8e-05	-7.96	-6.4	1.8e-10	0.22	0.49	0.03	FALSE
59	The Cancer Genome Atlas	Prostate Adenocarcinoma	SERPINF1	0.06	0.03	blup	68	0.05	8.8e-06	9.64	-5.7	1.4e-08	-0.19	0.14	0.72	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	SMG6	0.04	0.01	blup	144	0.02	5.5e-03	1.83	5.2	2.3e-07	-0.01	0.06	0.43	FALSE
61	The Cancer Genome Atlas	Prostate Adenocarcinoma	SMYD4	0.08	0.09	lasso	9	0.08	6.3e-09	9.56	-9.4	4.7e-21	0.05	0.01	0.99	FALSE
62	The Cancer Genome Atlas	Rectum Adenocarcinoma	SRR	0.52	0.32	lasso	3	0.40	1.7e-10	4.00	-5.6	2.2e-08	0.05	0.05	0.88	FALSE
63	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C17orf91	0.22	0.02	enet	17	0.12	4.9e-05	0.33	-7.5	9.2e-14	0.42	0.01	0.14	FALSE
64	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SRR	0.35	0.07	enet	11	0.14	1.1e-05	4.12	-5.4	7.1e-08	0.06	0.01	0.97	FALSE
65	The Cancer Genome Atlas	Thyroid Carcinoma	SMYD4	0.08	0.09	lasso	3	0.07	3.5e-07	9.80	-9.9	4.2e-23	0.05	0.01	0.99	FALSE