TWAS hub - RPA1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1340	0.0410	2.1e-04	0.081	0.031	0.051	0.070	0.082	4.7e-10	9.8e-05	7.9e-07	6.5e-09	3.3e-10
2	GTEx	Adipose Subcutaneous	0.1070	0.0440	5.1e-03	0.025	NA	0.054	NA	0.032	3.5e-03	NA	2.9e-05	NA	1.2e-03
3	GTEx	Artery Aorta	0.1930	0.0690	1.8e-03	0.042	NA	0.112	NA	0.063	2.3e-03	NA	9.3e-07	NA	2.4e-04
4	GTEx	Artery Tibial	0.2094	0.0564	8.5e-05	0.054	NA	0.080	NA	0.089	4.6e-05	NA	7.5e-07	NA	1.9e-07
5	GTEx	Cells Transformed fibroblasts	0.1850	0.0620	9.7e-04	0.123	NA	0.122	NA	0.107	1.9e-09	NA	1.9e-09	NA	2.2e-08
6	GTEx	Esophagus Muscularis	0.2680	0.0740	3.6e-04	0.101	NA	0.119	NA	0.101	1.1e-06	NA	1.1e-07	NA	1.1e-06
7	GTEx	Nerve Tibial	0.2405	0.0595	5.2e-05	0.042	NA	0.087	NA	0.076	6.2e-04	NA	9.9e-07	NA	5.0e-06
8	METSIM	Adipose	0.0820	0.0259	4.5e-05	0.021	0.031	0.050	0.042	0.034	3.8e-04	1.4e-05	5.8e-08	5.1e-07	6.3e-06
9	ROSMAP	Brain Pre-frontal Cortex	0.0945	0.0310	4.6e-04	0.031	0.036	0.030	0.039	0.021	6.9e-05	1.9e-05	7.6e-05	7.4e-06	9.3e-04
10	YFS	Blood	0.0459	0.0153	1.9e-04	0.017	0.018	0.033	0.035	0.032	1.6e-06	1.4e-06	5.0e-11	9.4e-12	8.1e-11
11	TCGA	Brain Lower Grade Glioma	0.0313	0.0154	6.2e-03	0.032	0.015	0.017	NA	0.017	1.4e-04	7.2e-03	4.4e-03	NA	4.4e-03
12	TCGA	Prostate Adenocarcinoma	0.0684	0.0323	2.3e-03	0.005	0.015	0.003	NA	0.004	9.9e-02	9.0e-03	1.4e-01	NA	1.1e-01
13	TCGA	Thyroid Carcinoma	0.1350	0.0440	2.2e-05	0.091	0.062	0.072	NA	0.088	3.3e-09	1.2e-06	1.4e-07	NA	6.7e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Supplements: Vitamin C	6.2	7.4	14.6	-1.3	-3.0	-3.3	-2.4	-2.9	-3.0	-2.9	-2.6	-3.8	-3.0	-0.3	-3.1	-1.6
Breastfed as a baby	4.0	5.0	10.0	2.2	2.0	2.8	1.8	3.1	1.0	2.6	2.5	1.5	3.2	1.1	2.2	1.8
Pulse wave reflection index	3.5	4.3	15.6	-1.3	-2.2	-2.1	-1.6	-2.0	-1.8	-1.5	-1.8	-1.6	-2.7	-3.9	-1.4	-1.4
Breast Cancer	2.7	6.6	16.5	0.0	2.6	3.0	1.6	2.6	2.5	2.3	2.7	0.4	3.6	-0.1	4.1	3.4
Neck or shoulder pain in last month	2.6	3.6	6.8	2.4	1.6	2.4	1.4	2.3	1.4	2.1	2.4	0.4	2.6	2.4	0.1	1.1
Mouth/teeth dental problems: Loose teeth	2.5	3.0	6.1	0.4	1.9	1.0	1.8	1.4	2.0	2.0	2.3	0.7	2.1	2.2	0.7	2.5
Fasting Glucose	2.4	2.9	6.9	-0.1	-2.3	-2.4	-2.6	-1.3	-2.5	-1.4	-1.6	-0.9	-1.8	-1.1	-1.1	-1.2
Family relationship satisfaction	2.4	2.9	7.5	-2.1	-1.5	-2.0	-1.7	-1.6	-1.2	-1.7	-2.4	-1.4	-0.4	-2.7	-0.1	1.5
Ever used hormone-replacement therapy (HRT)	2.3	2.9	10.5	0.2	-2.7	-1.3	-2.7	0.3	-3.2	-0.8	-2.5	0.1	0.4	-0.4	-0.9	1.6
Mineral and other dietary supplements	2.1	2.8	6.4	0.8	2.4	1.1	2.5	1.2	2.4	1.4	2.0	1.1	1.1	2.4	1.1	-0.6
Supplements: Calcium	2.0	2.2	6.9	-0.4	-2.5	-2.6	-1.6	-0.8	-2.1	-0.8	-1.0	-0.3	-1.8	1.3	-1.0	-0.6
Stomach or abdominal pain in last month	1.9	2.3	6.9	1.8	1.2	1.9	2.0	0.9	0.4	2.2	0.8	1.1	-0.1	2.6	0.1	-1.9
Number of live births	1.9	2.6	10.8	1.2	1.3	1.9	1.1	1.5	1.1	2.7	3.3	1.1	1.5	0.5	0.1	1.1
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.1	5.0	0.5	1.5	1.5	1.3	1.4	2.0	1.6	2.2	1.1	1.6	1.8	0.8	0.6
Number of self-reported non-cancer illnesses	1.8	3.0	8.5	2.9	0.5	2.3	-0.5	2.5	-1.0	2.6	1.0	1.0	2.6	1.1	-0.2	1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.7	3.8	11.1	3.3	1.9	3.0	0.5	2.8	0.5	2.4	1.2	2.1	2.3	-0.3	0.5	-0.3
Supplements: Fish oil (including cod liver oil)	1.7	2.3	6.5	-0.8	-2.1	-0.9	-2.3	-1.2	-2.5	-1.2	-1.5	-1.6	-0.6	-1.2	-0.9	1.3
Vitamin and mineral supplements	1.6	2.2	5.5	0.8	2.3	2.3	1.4	1.1	2.0	1.2	1.3	1.7	1.9	-0.2	0.4	0.1
Medication: Co-codamol	1.6	1.9	10.2	0.2	0.3	0.5	1.4	0.9	1.0	0.5	1.5	1.9	-0.6	3.2	1.4	-1.1
Mouth/teeth dental problems	1.6	2.5	7.0	-0.7	-1.3	0.1	-0.8	-1.5	-0.1	-2.0	-1.6	-0.4	-2.4	-2.5	-1.2	-2.6
Fluid intelligence score	1.6	3.4	10.3	1.3	2.4	1.3	3.2	1.5	1.9	1.3	0.4	2.3	-0.4	-0.2	2.1	-2.5
Pulse rate	1.6	2.7	7.0	-0.8	0.9	0.1	2.6	0.8	2.3	0.8	1.1	2.3	0.1	2.6	2.6	-0.0
Ever had bowel cancer screening	1.6	1.9	6.6	1.7	0.7	1.1	0.0	1.8	-0.1	2.6	-0.9	1.4	2.2	-0.4	-0.0	1.5
Illnesses of father: High blood pressure	1.6	1.9	6.5	0.2	1.3	1.4	0.5	1.3	0.7	1.2	0.9	2.5	1.9	-0.5	1.9	1.6
Alcohol drinker status: Previous	1.6	1.8	4.5	2.1	-1.7	0.8	-1.6	1.4	-1.8	0.6	-0.5	1.1	1.6	1.6	-0.4	0.9
Heel T-Score	1.5	12.1	49.0	5.2	3.9	7.0	1.8	4.6	1.7	3.1	1.3	2.8	4.3	0.3	0.9	0.3
Diabetes (mother)	1.5	1.9	6.2	-0.1	-1.1	-1.5	-1.1	-1.5	-1.7	-1.4	-0.7	-1.6	-1.1	1.2	-2.5	-0.7
Hip circumference	1.5	6.3	12.1	2.6	3.4	3.2	2.0	2.9	2.5	2.5	3.1	1.7	3.5	2.0	-0.3	0.3
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	4.1	1.6	1.8	0.1	1.3	1.4	0.8	1.6	1.4	-0.5	2.0	2.0	0.6	1.7
Osteoporosis (self-reported)	1.5	1.8	5.7	-0.3	-2.0	-1.4	-2.0	-0.5	-2.3	-0.5	-2.4	-1.2	-0.0	-0.6	-0.6	0.8
Medication: Amlodipine	1.4	1.9	5.6	0.5	-1.7	-0.2	-1.6	0.6	-2.4	-0.1	-1.1	1.8	1.0	1.9	0.5	1.9
Comparative body size at age 10	1.4	3.9	8.4	0.3	2.9	2.4	2.3	0.8	1.6	1.2	2.1	2.4	2.6	2.4	1.5	1.1
Worry too long after embarrassment	1.4	2.4	13.3	0.5	-0.4	2.3	-0.5	1.2	-1.3	1.0	-0.5	3.6	1.2	0.8	1.6	1.8
Age at first live birth	1.4	2.5	6.7	-1.7	-1.9	-2.5	-1.5	-1.1	-1.0	-2.1	-2.6	0.3	-0.9	-1.4	1.0	0.7
Illnesses of siblings: Diabetes	1.4	1.7	9.6	0.0	1.0	0.7	1.3	0.4	1.5	1.0	3.1	0.3	1.1	1.2	1.3	1.0
Smoking status: Previous	1.4	2.1	8.9	3.0	0.3	0.6	-0.2	2.1	-1.0	2.0	0.8	0.8	1.7	1.9	-0.6	0.4
Medication: Gliclazide	1.4	1.6	6.2	-1.3	1.2	0.3	1.3	-0.3	1.2	-0.2	2.5	0.3	1.0	2.1	0.8	1.2
Diastolic blood pressure, automated reading	1.4	4.5	12.1	-0.2	2.1	3.0	0.7	1.2	0.9	1.2	2.3	2.6	3.5	2.1	1.4	3.2
Triglycerides	1.3	2.1	5.8	-0.5	-1.1	-1.3	-1.4	-1.8	-1.1	-2.0	-0.4	-2.4	-1.0	-0.6	-2.4	-0.4
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	4.9	1.9	0.7	0.7	1.0	2.2	1.0	1.8	1.2	1.1	1.2	1.4	1.2	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	11.9	3.4	1.1	2.6	-0.2	2.4	-0.2	1.8	0.5	1.8	2.3	-0.0	-0.1	-0.0
Qualifications: A levels/AS levels or equivalent	1.3	2.9	9.4	-1.3	-1.4	-2.4	0.0	-1.4	-0.6	-1.6	-1.3	-0.2	-3.1	-2.4	0.4	-2.5
Length of working week for main job	1.3	1.4	5.7	1.0	0.2	2.4	0.7	1.6	0.6	0.8	0.4	0.6	1.3	2.2	0.7	-0.3
Medication: Ventolin 100micrograms inhaler	1.3	1.6	5.5	-0.7	-1.4	-1.3	-2.3	-1.3	-1.9	-0.7	-1.1	-1.3	-0.6	-0.6	-1.4	0.1
Age at last live birth	1.3	1.9	7.1	-0.3	-1.7	-2.7	-1.6	-0.2	-0.9	-1.4	-2.3	-1.2	-0.7	-1.5	-0.3	-0.2
Friendships satisfaction	1.3	1.6	4.2	-1.0	-1.2	-2.0	-1.6	-0.8	-1.5	-0.9	-1.6	-0.8	-0.5	-1.7	0.9	0.7
Eye problems/disorders: Cataract	1.3	1.5	4.8	-0.1	-1.0	-0.5	-1.6	-1.3	-1.0	-1.3	-1.2	-2.0	-0.6	-0.4	-2.2	-0.3
Vascular/heart problems diagnosed by doctor	1.3	3.5	12.5	-1.6	-1.1	-3.5	1.2	-1.4	1.3	-1.5	-1.8	-1.1	-3.4	-0.8	0.4	-2.4
BMI	1.2	6.8	16.4	0.3	4.0	3.3	2.9	1.8	3.2	1.0	3.0	2.1	3.2	3.4	1.1	1.0
Chronotype (morning person)	1.2	2.9	7.6	2.5	1.0	0.9	1.5	2.8	1.0	2.1	1.2	2.2	0.3	1.8	1.8	-0.9
Average weekly fortified wine intake	1.2	1.4	5.3	-1.4	-1.8	-2.3	-0.3	-1.5	-1.1	-0.5	1.0	-0.1	-1.4	0.3	0.5	-0.0
Number of incorrect matches in round	1.2	1.9	5.1	-0.5	-2.1	-1.6	-2.2	-0.7	-2.3	-0.7	-1.8	-0.4	-0.0	-0.8	-0.6	1.6
Past tobacco smoking	1.2	2.1	9.1	-3.0	-1.0	-0.4	-0.4	-2.3	0.5	-1.8	-1.0	-0.3	-1.5	-2.3	0.3	-0.1
Alcohol usually taken with meals	1.2	1.9	9.6	0.4	1.5	0.2	3.1	-0.1	1.7	0.8	1.8	0.4	-0.8	1.9	0.6	-1.1
Pain all over the body in last month	1.2	1.3	3.1	0.4	0.8	0.9	1.6	0.4	1.0	1.4	0.6	1.8	0.1	1.7	1.3	-1.2
Impedance of arm (right)	1.2	5.6	16.8	-2.2	-4.1	-2.8	-2.8	-2.0	-2.7	-2.3	-3.2	0.3	-2.3	-1.8	0.2	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	4.8	2.2	0.1	1.4	-0.5	1.9	-1.0	1.8	-0.1	1.1	2.1	0.6	-0.1	1.6
Pulse wave peak to peak time	1.2	1.4	3.9	2.0	1.2	1.1	1.0	1.3	1.1	1.3	0.8	0.6	1.2	1.9	-0.2	-0.3
Arm predicted mass (right)	1.2	5.9	15.4	3.9	3.2	2.4	1.3	2.9	1.7	2.4	2.4	-0.9	3.8	1.6	-1.7	0.4
Hypertension (Self-reported)	1.2	3.2	9.8	1.1	0.9	3.0	-0.8	1.2	-1.2	1.3	1.4	2.1	3.1	1.4	0.3	2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.9	-0.3	-1.1	-1.5	-1.4	-0.5	-0.8	-1.4	-1.7	-2.0	-0.7	-1.2	-0.8	-0.3
Neuroticism (Nagel 2018)	1.1	2.5	15.9	0.7	-1.0	1.1	-0.9	0.8	-2.0	0.6	-2.4	4.0	0.2	-0.2	1.4	0.7
Worry (Nagel 2018)	1.1	2.3	8.8	1.6	-1.1	0.5	-1.5	0.9	-2.6	1.5	-1.5	3.0	0.9	-0.2	0.2	1.4
Verbal and Numeric Reasoning (VNR)	1.1	2.5	8.7	1.8	2.3	1.1	2.3	1.4	1.2	1.4	0.6	1.4	-0.5	-0.9	0.4	-3.0
Neuroticism (2016)	1.1	1.6	7.0	0.9	-1.3	1.1	-0.9	0.7	-1.8	0.2	-2.0	2.6	-0.2	0.9	1.0	-0.2
Supplements: Zinc	1.1	1.1	9.0	-0.1	-1.8	-3.0	-0.7	-0.1	-0.7	0.1	-0.1	-0.1	-1.1	0.4	0.4	0.2
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	3.1	-0.8	-0.6	-0.8	-1.4	-1.1	-1.2	-1.2	-0.9	-1.4	0.1	-1.2	-1.8	1.2
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	5.9	-1.7	0.4	0.1	-0.1	-0.3	1.1	-0.0	0.9	-0.3	1.4	0.7	1.4	2.4
High blood pressure	1.1	3.2	12.1	1.3	0.8	3.5	-1.0	1.3	-1.1	1.4	1.8	1.6	3.0	1.0	0.1	2.2
Body mass index (BMI)	1.1	4.6	10.2	1.0	3.2	3.0	2.0	1.5	2.2	1.4	2.5	1.9	2.8	2.7	-0.1	0.5
Waist circumference	1.1	3.9	12.0	1.4	2.7	3.1	0.9	1.5	1.7	1.6	1.9	1.6	3.5	1.9	-0.5	0.9
Nervous feelings	1.1	2.0	6.6	1.5	-1.1	0.1	-1.3	1.0	-2.6	1.2	-1.2	2.4	1.1	0.6	-0.5	1.5
Illnesses of siblings	1.1	1.5	6.2	-0.1	-0.8	-2.1	0.3	-0.3	-0.0	-0.8	-1.5	-0.5	-2.5	-0.8	-0.4	-2.1
Worrier / anxious feelings	1.1	2.1	13.5	1.3	-0.6	0.5	-0.7	1.2	-1.6	1.1	-0.9	3.7	0.9	0.2	1.4	1.5
Medication: Lansoprazole	1.1	1.2	5.4	1.2	-0.0	0.1	-0.6	-0.3	-2.0	-0.6	0.1	-1.3	0.5	2.3	-1.4	-0.7
Medication: Paracetamol	1.1	1.7	8.5	-0.9	-1.6	-0.9	0.2	-1.1	0.1	-0.7	-1.1	0.6	-2.9	-0.1	-0.5	-2.5
Chronic bronchitis/emphysema (mother)	1.1	1.3	4.5	0.2	1.0	1.1	1.0	0.7	1.0	1.0	0.4	1.5	1.6	2.1	0.3	1.2
Eye problems/disorders: None of the above	1.1	1.3	2.9	0.9	1.3	1.1	1.2	1.3	0.3	0.8	0.5	1.7	1.6	0.6	1.3	1.3
Mother’s age at death	1.1	1.4	5.3	-0.7	-1.3	-2.1	-1.0	-0.2	-1.4	-0.9	-1.0	-1.2	0.4	0.4	-0.1	2.3
Commuting to job workplace: Public transport	1.1	1.3	5.4	0.8	-1.7	-2.3	-0.2	-0.3	-1.2	-0.2	-1.1	0.6	-1.5	1.0	-0.0	-1.3
Pain type(s) experienced in last month: Hip pain	1.1	1.4	4.0	1.7	0.6	0.1	0.8	1.3	0.8	2.0	1.2	1.3	1.1	1.9	-0.1	-0.1
Arm fat-free mass (left)	1.1	5.4	12.5	3.2	3.4	2.8	1.4	2.5	2.3	1.9	2.5	-0.8	3.5	1.3	-1.8	0.4
Risk taking	1.1	1.7	7.4	1.1	-0.1	-1.6	0.2	0.2	-0.1	-0.4	-0.8	-2.7	-1.1	1.1	-1.5	-2.2
Alzheimer’s Disease (including proxy)	1.0	1.5	6.6	-0.5	-1.1	-2.6	-0.9	-0.8	-1.0	-0.8	-1.5	-0.8	-1.1	1.6	-1.2	-0.5
Irritable Bowel Disease (IBD)	1.0	2.3	6.0	-0.3	-2.1	-1.0	-0.9	-1.1	-1.4	-1.4	-2.5	-1.2	-2.3	-1.0	-1.4	-1.7
Ulcerative Colitis (UC)	1.0	2.0	6.4	-0.4	-1.1	-1.0	0.1	-1.2	-0.4	-1.1	-2.1	-0.6	-2.5	-0.7	-1.5	-2.5
Systolic blood pressure, automated reading	1.0	2.9	9.2	-0.6	1.1	2.4	0.4	0.8	0.2	0.9	1.7	2.3	2.6	1.8	1.2	3.0
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	5.7	1.0	-1.1	0.4	-0.9	0.5	-2.2	0.3	-2.2	2.4	-0.2	1.0	0.2	-0.2
Hair/balding pattern: Pattern 2	1.0	1.3	5.2	-1.4	0.5	-1.1	0.1	-1.6	0.2	-1.4	-0.8	-2.3	-1.7	-0.3	-0.8	-0.6
Had menopause	1.0	1.3	4.3	1.0	-0.3	0.8	-0.8	1.6	-1.0	1.4	-0.5	0.5	1.8	0.8	-0.2	2.1
Lung cancer (father)	1.0	1.2	3.5	-0.3	-0.9	-1.9	-1.2	-1.2	-0.3	-0.9	-0.7	-1.1	-1.1	-0.2	-1.5	-1.2
Pulse wave Arterial Stiffness index	1.0	1.2	3.6	-1.7	-1.1	-1.0	-0.9	-1.0	-1.1	-1.1	-0.6	-0.8	-0.7	-1.9	0.3	0.7
Trunk predicted mass	1.0	5.5	13.7	3.3	3.4	2.6	1.6	2.5	2.4	2.1	2.4	-0.6	3.7	1.1	-1.5	0.5
High blood pressure (siblings)	1.0	1.5	8.5	-0.7	-0.0	1.5	-0.7	-0.1	-0.2	-0.4	0.0	1.0	2.2	-0.7	1.0	2.9
Arm fat-free mass (right)	1.0	5.4	13.0	3.5	3.1	2.7	1.4	2.7	1.9	2.2	2.2	-0.8	3.6	1.2	-1.4	0.5
Illnesses of father: Heart disease	1.0	1.4	4.2	1.4	0.8	2.0	0.6	1.7	-0.1	1.3	0.2	2.0	1.1	-0.9	1.0	0.2
Mood swings	1.0	1.7	4.2	-0.6	-1.0	0.1	-1.0	-0.8	-1.7	-1.1	-2.0	1.9	-2.0	-0.5	1.0	-1.7
Medication: Blood pressure	1.0	1.8	11.1	0.2	0.5	3.3	-0.4	0.7	0.0	0.4	1.2	1.2	2.0	-0.3	0.5	2.0
Ever had prostate specific antigen (PSA) test	1.0	1.2	3.3	-0.8	-0.6	0.3	-1.5	-0.7	-0.9	-1.5	-1.8	0.8	0.6	-1.2	-0.9	1.2
Commuting to job workplace: Cycle	1.0	1.3	5.7	0.1	-0.5	-0.3	0.6	-0.5	0.1	-0.5	-1.6	-1.4	-1.6	-1.5	-0.3	-2.4
Leg fat mass (left)	1.0	3.8	12.0	1.2	2.6	2.8	0.9	1.9	1.7	1.5	2.1	1.1	3.5	2.0	-0.0	1.5
Arm predicted mass (left)	1.0	5.0	12.8	3.0	3.3	2.5	1.1	2.4	2.0	1.8	2.5	-1.1	3.6	1.2	-1.6	0.6
Schizophrenia (2018)	0.9	1.9	5.2	-1.4	-1.8	-1.4	-1.3	-1.8	-1.1	-0.5	-0.8	-2.3	-1.1	-1.8	0.3	0.7
Lupus	0.9	1.3	7.2	0.7	0.4	-0.2	0.5	0.9	0.4	1.3	1.2	0.1	2.3	-0.1	-0.1	2.7
Neuroticism	0.9	2.2	10.4	0.2	-1.8	0.0	-1.3	-0.1	-2.3	-0.6	-2.5	3.2	-0.3	-0.5	0.8	0.6
Severe depression (siblings)	0.9	1.0	2.7	-0.5	-0.8	-1.6	-1.0	-1.4	-0.6	-0.1	-0.9	-1.6	0.0	0.2	-1.5	0.9
Weight	0.9	4.3	14.8	2.1	2.8	2.9	0.7	2.0	1.5	1.6	2.0	0.5	3.9	1.7	-1.3	1.2
Trunk fat-free mass	0.9	5.4	13.4	3.3	3.4	2.6	1.5	2.5	2.3	2.1	2.4	-0.6	3.7	1.0	-1.5	0.4
Happiness	0.9	1.1	3.3	-1.2	-0.8	-0.9	-0.6	-0.3	-0.7	-0.7	-1.6	0.1	-0.6	-1.7	1.8	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	13.2	3.6	1.4	1.1	-0.2	2.5	0.1	1.2	0.6	-2.0	2.5	-1.0	-1.5	-0.5
Birth weight of first child	0.9	1.6	4.9	2.0	-0.7	0.1	-1.7	1.1	-2.2	0.6	-1.6	-1.4	0.9	-1.0	-1.0	-0.3
Leg fat mass (right)	0.9	3.3	10.4	1.1	2.5	2.6	0.8	1.8	1.7	1.3	1.9	1.0	3.2	1.8	-0.1	1.3
Whole body fat-free mass	0.9	4.9	13.8	3.2	3.1	2.3	1.3	2.4	1.9	1.9	2.2	-0.2	3.7	1.5	-1.6	0.7
Qualifications: nursing, teaching	0.9	1.5	6.9	-0.0	0.2	-1.6	1.4	-0.3	0.2	-0.3	-0.5	-0.6	-2.6	-0.3	0.5	-2.6
Medication for cholesterol	0.9	1.3	5.8	0.1	-0.2	-2.4	0.7	-0.6	0.3	-0.2	-1.4	-1.1	-1.8	0.1	-0.4	-1.9
Illnesses of father: None of the above (group 1)	0.9	1.1	4.1	-0.9	0.5	-1.5	0.8	-1.4	0.9	-0.8	0.3	-1.0	-1.6	0.3	-0.1	-2.0
Wears glasses or contact lenses	0.9	1.0	2.6	0.9	0.6	1.0	-0.3	1.0	-0.8	1.6	0.9	1.1	1.3	1.4	0.2	1.0
Pain experienced in last month	0.9	1.5	7.4	-1.6	-0.9	-0.7	-1.1	-0.7	-0.8	-1.7	-0.9	-0.7	-0.5	-2.7	0.8	1.1
Depressed Affect (Nagel 2018)	0.8	1.6	6.8	0.1	-1.2	-0.0	-1.3	-0.3	-1.8	-0.5	-2.6	2.0	-1.2	-0.8	0.3	-1.0
Schizophrenia vs Biploar Disorder	0.8	1.1	4.1	0.0	-2.0	-1.1	-1.5	-1.7	-0.1	0.0	0.0	-0.4	-1.2	-1.5	0.0	0.0
Schizophrenia (2014)	0.8	1.8	4.4	-0.9	-1.8	-1.7	-1.4	-1.3	-1.5	-0.2	-0.9	-2.1	-0.9	-2.1	-0.3	0.5
Ulcerative Colitis	0.8	1.1	4.6	0.3	-0.8	-0.1	-0.0	-0.6	-0.8	0.2	-1.9	-0.8	-1.7	-0.1	-1.0	-2.2
Blood White Count	0.8	5.7	22.0	-2.7	-0.4	-3.8	2.8	-1.6	2.9	-1.3	0.5	-0.1	-4.7	1.3	1.5	-2.5
Current tobacco smoking	0.8	1.3	3.1	-0.9	0.4	-1.6	1.6	-0.5	1.6	-0.2	0.1	-0.4	-1.7	1.2	0.4	-1.8
Maternal smoking around birth	0.8	1.2	4.1	1.9	-0.1	-0.5	0.9	1.4	0.1	1.2	-0.2	0.9	-0.7	2.0	0.5	-1.3
Fed-up feelings	0.8	1.4	4.0	1.0	-1.7	-0.7	-1.0	-0.1	-2.0	-0.4	-1.8	1.6	-1.3	0.4	-0.0	-1.1
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	3.8	-1.3	-1.2	-0.4	-0.8	-1.3	-0.3	-1.0	-0.7	-0.9	-1.9	-0.7	0.0	-1.1
Neuroticism score	0.8	1.7	8.5	1.1	-1.2	0.8	-1.2	0.5	-2.2	-0.3	-1.8	2.9	-0.2	0.2	0.8	-0.2
Falls in the last year	0.8	1.1	8.5	1.6	0.4	0.1	0.4	0.5	-0.6	0.5	-0.9	0.3	-0.8	0.1	-0.6	-2.9
Impedance of arm (left)	0.8	3.8	14.3	-1.4	-3.8	-2.4	-2.2	-1.1	-2.5	-1.3	-2.7	0.6	-1.9	-1.2	0.6	0.4
Arm fat mass (right)	0.8	3.1	8.5	0.6	2.3	2.5	1.2	1.2	1.9	0.9	1.9	1.8	2.9	2.1	-0.0	1.2
Headache pain in last month	0.8	1.4	4.5	1.5	0.9	-0.1	1.3	1.0	0.8	1.8	2.1	0.6	0.9	1.4	0.6	0.1
Forced vital capacity (FVC), Best measure	0.8	3.0	13.9	3.7	0.7	0.9	-1.2	2.6	-0.5	1.1	-0.1	-1.4	2.9	-1.2	-1.7	0.4
Shortness of breath walking on level ground	0.8	1.0	2.6	0.0	-1.0	-1.2	-1.0	-0.3	-0.6	-0.9	-1.1	1.3	-0.9	-0.3	-1.2	-1.6
Medication: Ibuprofen	0.8	0.9	4.8	0.4	-0.5	-1.0	1.1	-0.6	0.3	-0.1	-1.0	-0.3	-1.7	-0.2	-0.2	-2.2
Average weekly red wine intake	0.8	1.2	2.5	1.6	1.3	0.0	1.5	1.0	0.6	1.5	1.3	0.4	-0.2	1.1	-0.2	-1.5
Smoking status: Current	0.8	1.2	3.2	-1.0	0.1	-1.7	1.4	-0.7	1.4	-0.6	-0.2	-0.6	-1.8	0.8	0.4	-1.7
Whole body water mass	0.8	4.5	12.5	3.1	3.0	2.1	1.2	2.3	1.9	1.8	2.2	-0.4	3.5	1.4	-1.7	0.5
Basal metabolic rate	0.8	4.7	13.8	3.0	3.0	2.4	1.1	2.3	1.8	1.8	2.2	-0.2	3.7	1.6	-1.6	0.7
Cholesterol lowering medication	0.8	1.2	5.8	0.9	0.7	2.4	0.4	1.4	0.9	1.3	1.3	0.3	1.1	0.5	0.2	0.4
Impedance of whole body	0.8	4.1	13.3	-1.6	-3.6	-2.1	-2.5	-1.1	-2.3	-1.5	-2.6	-0.9	-2.0	-2.4	0.7	0.6
Alzheimer’s Disease (in father)	0.7	0.7	2.0	-0.7	-1.4	-1.4	-0.6	-0.4	-0.7	-0.8	-0.9	-1.1	-1.0	0.4	-0.3	-0.3
Major Depression (MDD)	0.7	0.8	3.3	-1.8	0.2	-0.6	1.4	-0.7	1.2	-0.2	0.0	0.5	-1.3	-0.5	1.0	-0.1
Primary Biliary Cirrhosis	0.7	1.1	5.2	0.7	0.2	-0.5	-0.9	-0.8	-0.5	-0.8	-0.8	-1.7	-0.2	-0.1	-2.3	-1.2
Rheumatoid Arthritis	0.7	1.0	2.8	0.7	1.7	1.4	0.9	0.0	1.2	1.0	1.2	0.6	1.2	0.9	-0.5	0.0
Blood Platelet Count	0.7	8.0	28.9	-3.3	-1.8	-5.4	0.7	-2.9	-0.1	-2.6	-1.6	-2.5	-5.0	0.0	1.6	-2.8
Cardiovascular Disease	0.7	2.4	8.8	1.5	0.8	2.7	-0.7	1.5	-0.8	0.8	1.1	1.2	3.0	0.7	-0.7	2.1
Frequency of depressed mood in last 2 weeks	0.7	1.0	4.3	0.3	0.5	1.0	1.0	0.8	0.0	0.8	-0.2	2.1	0.4	1.6	1.3	0.6
Relative age of first facial hair	0.7	1.5	5.1	-2.2	-1.6	-1.1	-1.1	-1.8	-0.3	-1.9	-0.6	-0.7	-0.7	-0.7	0.1	0.8
Leg fat-free mass (left)	0.7	3.5	11.6	2.7	2.5	1.7	1.0	2.0	1.2	1.4	1.5	0.5	3.4	2.0	-1.6	0.6
Age when periods started (menarche)	0.7	1.8	7.3	-0.5	-0.8	-1.4	-0.2	-1.3	-0.7	-0.9	-1.6	-0.4	-2.7	-0.6	-0.8	-2.6
Qualifications: None of the above	0.7	1.6	7.4	-1.4	-0.6	0.3	-1.9	-1.1	-1.0	-0.9	0.2	-0.5	1.4	0.1	-1.4	2.7
Father’s age at death	0.7	1.0	3.3	-0.3	-1.8	-1.8	-1.2	-0.7	-0.9	-0.5	-1.0	-0.1	-1.1	-0.4	-0.8	-0.2
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	11.3	3.4	1.1	0.5	-0.1	2.4	0.2	0.6	0.5	-1.5	2.3	-0.4	-1.2	-0.1
Depression (self-reported)	0.7	0.9	4.2	2.1	-0.2	-0.7	-0.1	0.7	-1.1	0.5	-1.0	-0.3	0.7	1.4	-1.2	0.1
Tense / ‘highly strung’	0.7	1.2	3.0	1.7	-0.1	0.9	-0.2	1.6	-1.5	1.4	-0.8	1.7	0.4	0.5	1.2	0.6
Leg fat percentage (right)	0.7	2.7	7.8	-0.1	2.3	2.8	0.9	1.3	1.9	1.0	1.9	0.9	2.3	1.5	0.8	1.2
Wheeze or whistling in the chest in last year	0.7	1.2	2.6	1.4	1.6	0.5	0.7	1.2	0.9	1.4	1.3	0.7	1.0	1.4	0.3	-0.7
Health satisfaction	0.7	0.9	4.1	-0.7	0.6	0.9	-0.0	0.5	0.8	0.6	0.7	2.0	1.1	0.4	1.5	0.8
Medication: Omeprazole	0.7	0.8	2.7	1.4	0.5	0.8	0.5	1.6	0.4	1.6	0.2	0.2	0.8	0.7	1.0	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	4.2	0.1	0.0	-0.3	1.9	0.8	0.6	0.5	0.3	2.0	-0.4	0.4	1.3	-0.6
Had major operations	0.7	0.8	2.8	0.5	1.0	1.1	1.4	0.7	0.3	0.4	0.8	1.7	0.5	-0.1	0.7	-0.7
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.7	0.1	0.9	1.1	-1.0	0.7	-0.3	0.5	0.7	0.2	1.6	1.1	-0.1	1.2
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.8	-1.0	-0.9	-0.8	-1.3	-1.4	-1.0	-1.0	-1.0	-0.3	-0.4	-0.7	-0.1	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	3.6	-0.3	-1.1	-0.6	-0.1	0.6	-0.0	-0.3	-1.3	0.5	0.5	-1.0	0.5	1.9
Breast cancer (self-reported)	0.7	0.8	2.4	-1.4	-1.0	-0.8	-0.5	-1.0	-0.0	-1.6	-1.1	0.8	-1.1	0.1	-0.3	0.3
Osteoarthritis (self-reported)	0.7	0.9	4.6	2.1	0.3	1.0	0.5	1.4	0.5	1.3	0.7	-0.3	0.4	0.4	-0.3	-0.8
Arm fat mass (left)	0.7	2.8	7.6	0.8	2.2	2.4	1.2	1.2	1.7	0.9	1.9	1.5	2.8	2.1	-0.2	0.9
Guilty feelings	0.7	1.0	5.8	-0.1	-0.5	1.1	0.1	-0.0	-0.7	0.1	-2.0	2.4	-0.0	1.0	0.8	0.2
Ever smoked	0.7	1.2	4.7	2.2	1.0	-0.6	0.1	1.6	-0.5	1.1	0.9	-0.8	0.8	1.7	-0.5	-0.2
Leg fat percentage (left)	0.7	2.6	7.8	-0.1	2.2	2.8	0.6	1.2	1.7	1.0	2.0	0.8	2.5	1.4	0.7	1.6
Bipolar Disorder or Schizophrenia	0.6	1.4	7.5	-0.2	-1.0	-1.0	-1.3	-1.2	-1.5	0.1	-0.5	-2.7	-0.3	-1.5	-0.4	0.3
Depression (Nagel 2018)	0.6	0.9	3.8	0.4	-0.7	0.9	-0.4	0.9	-0.7	1.0	-1.5	2.0	0.2	0.0	1.1	0.2
Crohns Disease (2017)	0.6	1.4	3.9	-0.3	-1.8	-0.5	-1.1	-0.7	-1.0	-1.1	-2.0	-1.4	-1.3	-1.5	-0.4	-0.6
Crohns Disease (2012)	0.6	0.9	5.0	-0.3	-0.4	1.1	-1.4	-0.6	-0.9	-0.4	0.1	-2.2	0.6	-1.2	-0.3	0.0
HbA1C	0.6	0.6	1.9	0.9	0.1	-0.8	-0.8	1.3	-0.7	0.3	-1.4	-0.2	0.1	-0.6	-0.7	-1.1
Respiratory disease	0.6	1.3	4.6	0.1	-1.7	-0.4	-2.1	-0.6	-2.0	-0.0	-1.0	-0.3	-0.4	-0.4	-1.7	-0.5
Sensitivity / hurt feelings	0.6	1.0	6.0	0.3	-1.0	-0.0	-0.5	0.2	-1.3	-0.9	-1.7	2.5	-0.4	0.6	0.2	0.0
Diabetes (father)	0.6	0.7	1.7	-0.5	-1.3	-0.9	-1.0	-0.9	-1.0	-0.6	-0.3	-0.8	-1.0	-0.5	-1.1	-0.2
Hand grip strength (right)	0.6	1.5	8.6	-0.3	-0.1	0.6	-0.6	0.8	-0.4	-0.3	0.0	0.2	2.8	-1.2	0.1	2.9
Relative age voice broke	0.6	0.9	2.4	0.1	-1.5	-0.2	-1.2	-0.9	-1.2	-0.7	-0.6	-0.7	-1.2	-0.4	-1.2	-1.3
Leg predicted mass (left)	0.6	3.4	11.3	2.6	2.5	1.7	1.0	1.9	1.3	1.4	1.4	0.4	3.4	2.0	-1.6	0.7
Hearing difficulty/problems with background noise	0.6	0.9	2.1	-1.4	-0.8	-1.1	-0.9	-1.3	-0.4	-0.6	-0.7	1.1	-1.5	-0.7	0.5	-0.6
Forced vital capacity (FVC)	0.6	2.4	10.7	3.3	0.2	0.8	-1.2	2.4	-0.3	0.3	-0.2	-1.0	2.7	-1.0	-1.6	0.6
Diabetes (self-reported)	0.6	0.9	7.7	-0.1	0.1	0.3	0.9	0.0	-0.2	0.4	1.3	0.7	0.3	2.8	0.5	-0.0
Medication: Ramipril	0.6	0.7	2.1	0.1	-0.4	0.7	-1.5	0.5	-1.4	-0.1	-0.6	0.3	1.2	-0.1	-0.2	1.4
Arm fat percentage (right)	0.6	2.4	6.5	-0.7	1.7	2.2	1.1	0.4	1.7	0.2	1.6	2.5	2.0	2.0	0.8	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.9	1.6	0.4	1.0	0.5	0.9	-0.1	1.0	-0.8	1.7	-0.2	1.0	-0.2	-1.5
Hair/balding pattern: Pattern 3	0.6	0.9	2.6	0.6	-0.6	0.9	-0.3	0.4	-0.5	0.2	-1.1	1.4	-0.7	-1.5	1.0	-1.6
Noisy workplace	0.6	0.8	3.8	0.0	0.5	0.8	-0.7	0.8	0.5	0.3	0.5	-0.5	1.9	0.1	0.1	1.9
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	3.7	1.2	0.2	-0.1	1.5	0.2	0.5	0.9	-0.2	-0.7	-0.9	-0.0	-0.3	-1.9
Medication: Cholesterol lowering	0.6	0.9	4.2	-0.5	-0.6	0.4	-2.1	-0.5	-1.4	-0.4	-1.1	-1.0	0.6	-0.5	-0.8	0.7
Illnesses of mother	0.6	0.7	3.4	-0.2	0.0	0.3	0.4	-0.4	0.4	0.1	-1.4	-0.3	-1.1	-1.9	0.2	-1.5
Loud music exposure frequency	0.6	0.7	2.2	1.5	0.5	0.5	0.4	1.3	-0.1	1.4	0.5	1.0	0.7	0.0	0.6	-0.2
Gout (self-reported)	0.6	0.8	2.3	-0.5	1.4	0.6	-0.2	-0.7	0.9	-1.0	1.2	-1.4	0.6	-0.4	-1.5	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.2	-1.5	-0.2	-0.5	0.6	-0.4	0.2	-0.9	-0.9	1.0	0.1	0.4	1.5	1.3
Qualifications: College or University degree	0.6	1.7	6.4	0.3	-0.6	-2.5	-0.3	-0.6	-1.6	-0.5	-1.4	-1.4	-2.0	-1.1	0.2	-1.9
Emphysema/chronic bronchitis	0.6	0.6	2.3	0.1	-1.5	0.2	-0.4	-0.3	-1.3	0.1	-0.6	1.0	-0.6	1.2	-0.8	-0.1
Medication: Allopurinol	0.6	0.8	2.8	-0.3	0.7	0.1	-0.8	-1.0	0.0	-1.2	0.8	-1.5	0.3	-0.7	-1.7	0.2
Whole body fat mass	0.6	2.5	9.5	0.8	1.9	2.1	0.5	1.5	1.2	0.9	1.5	1.2	3.1	2.0	-0.2	1.5
Arm fat percentage (left)	0.6	2.6	7.3	-0.1	1.6	2.1	1.3	0.8	1.7	0.7	1.5	2.7	2.1	2.2	0.8	0.9
Long-standing illness, disability or infirmity	0.6	0.9	2.5	1.6	1.1	1.1	-0.4	0.7	0.3	1.4	0.8	0.9	0.6	0.3	-0.8	-1.3
Diabetes diagnosed by doctor	0.6	1.0	9.4	-0.5	0.1	0.2	0.7	-0.4	-0.1	0.1	1.7	-0.3	0.0	3.1	0.1	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.9	1.2	0.1	0.1	-0.1	1.0	-1.7	1.2	0.6	-1.4	0.9	1.0	-0.4	1.1
Asthma (self-reported)	0.6	1.3	3.6	0.4	-1.6	-1.3	-1.8	-0.4	-1.9	0.2	-0.8	-0.2	-0.5	-0.3	-1.8	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.7	0.8	0.2	1.0	-1.2	0.3	-0.8	-1.4	-0.9	-1.1	0.8	-1.5	-1.9	-0.6
Miserableness	0.6	1.0	3.8	1.6	-0.1	-0.3	0.2	0.5	-1.0	0.1	-0.9	1.9	-0.8	1.4	0.2	-1.6
Hearing aid user	0.6	0.6	2.2	-0.8	0.2	0.6	-0.7	0.1	-0.4	0.4	1.2	0.2	0.8	-1.0	1.0	1.5
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.1	1.4	0.5	0.2	-0.0	-0.1	0.4	-0.2	0.7	-1.1	-0.2	-0.4	-1.4	-1.4
Medication: Paracetamol	0.6	0.9	3.5	-0.5	-1.1	-0.7	0.2	-1.0	0.1	-0.5	-0.8	0.6	-1.9	0.7	-0.5	-1.8
Average weekly beer plus cider intake	0.6	0.9	2.7	1.6	1.0	1.4	0.2	1.3	1.1	0.5	0.8	0.1	1.2	0.2	-0.4	-0.7
Ever depressed for a whole week	0.6	0.8	2.6	-0.0	-1.1	-1.2	-0.9	-0.6	-1.4	-0.7	-1.6	0.1	-0.6	-0.7	-0.3	-0.1
Heart disease (siblings)	0.6	0.8	4.0	1.1	0.8	2.0	0.2	0.9	0.5	1.0	1.1	0.4	0.7	-0.6	-0.3	-0.5
Bipolar Disorder (2018)	0.5	0.8	3.4	1.8	0.6	0.2	-0.5	0.4	-1.1	0.9	0.2	-1.5	0.6	-0.2	-1.4	0.0
Intelligence (Savage-Jansen 2018)	0.5	1.5	5.5	1.4	1.6	-0.0	2.2	1.1	1.0	1.0	0.5	0.7	-0.9	0.2	0.7	-2.4
Alzheimer’s Disease (in mother)	0.5	0.6	2.1	0.5	-0.5	-1.5	-1.0	-0.0	-0.9	-0.1	-1.2	-0.1	0.1	0.7	-1.2	0.1
Ovarian Cancer	0.5	0.6	3.3	0.3	-0.8	-1.8	-0.8	-0.2	-0.6	-0.3	-1.0	-0.8	-0.3	-0.1	-1.0	0.4
Coronary Artery Disease (CAD)	0.5	0.5	3.3	0.0	-1.0	1.4	-0.4	-0.2	-0.2	-0.4	0.0	1.8	-0.4	-0.6	-0.1	0.0
Mean Putamen Volume	0.5	0.5	2.1	-1.2	-1.2	-0.5	-0.1	-0.8	-0.6	-0.3	-0.6	-0.3	-1.4	-0.0	0.4	-0.1
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.6	0.0	-0.5	-1.0	-1.2	-0.7	-0.6	-0.7	-0.7	-1.6	0.7	-0.5	-0.4	0.0
Type 2 Diabetes (T2D) (2018)	0.5	0.9	6.7	-0.7	0.4	-0.0	1.3	-0.2	0.7	0.1	1.0	-0.3	0.4	2.6	0.5	0.9
Hearing difficulty/problems: Yes	0.5	0.7	2.6	-0.8	0.9	1.6	0.4	0.0	1.2	0.3	1.1	1.4	0.1	-0.3	0.6	-0.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	4.8	-0.1	-0.1	-0.5	0.9	0.1	0.9	-0.4	0.3	0.6	-0.0	2.2	-0.0	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	3.0	0.5	-0.5	0.1	0.7	0.5	0.4	0.6	-0.4	1.7	-0.3	1.7	0.2	-0.5
Medication: Atenolol	0.5	0.7	2.0	-1.0	0.8	1.0	1.1	-0.2	0.9	-0.2	-0.5	1.4	0.1	1.0	0.7	0.4
High blood pressure (mother)	0.5	0.7	1.9	0.7	-1.0	-0.6	-1.2	0.4	-1.4	-0.3	0.1	-0.4	0.8	1.0	0.1	1.2
Impedance of leg (left)	0.5	2.4	7.3	-1.0	-2.2	-0.9	-2.1	-0.4	-1.3	-0.7	-1.3	-2.4	-1.4	-2.7	0.8	0.7
Heart attack	0.5	0.6	2.7	0.4	0.6	0.8	-0.8	0.2	-0.2	0.3	-0.5	1.2	1.6	-0.4	-0.6	1.1
Medication: Simvastatin	0.5	0.8	3.8	-0.3	0.1	1.9	-0.7	0.0	-0.5	0.4	-0.1	-0.9	1.2	0.8	-0.4	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.9	0.6	-0.6	-0.3	-0.6	0.4	-0.6	-0.3	-0.1	-0.9	-0.7	-1.3	-0.7	-1.4
Asthma	0.5	1.1	2.8	0.4	-1.3	-1.2	-1.6	-0.5	-1.6	0.2	-0.8	0.0	-0.6	-0.4	-1.7	-1.1
Exposure to tobacco smoke at home	0.5	0.5	4.4	0.3	-0.4	0.9	-0.1	0.5	-0.0	0.6	0.1	2.1	0.6	0.3	0.4	0.5
Blood clot in the leg (DVT)	0.5	0.6	2.2	0.4	0.5	0.4	1.5	1.0	1.2	0.6	0.3	0.8	-0.2	0.4	1.2	-0.1
Number of full brothers	0.5	0.7	1.6	0.6	0.4	-0.1	1.3	1.1	1.0	0.3	0.9	0.8	0.0	0.6	1.1	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.9	-0.8	0.6	0.7	0.1	0.2	1.3	-0.5	0.2	-0.2	0.1	-1.7	1.0	0.3
Medication for pain relief, constipation, heartburn	0.5	0.9	3.5	-0.1	1.9	0.9	0.2	0.3	0.5	-0.2	1.0	-0.6	1.6	-0.5	0.3	1.4
Heart disease (mother)	0.5	0.7	1.9	1.4	0.9	1.1	0.1	1.0	0.4	1.2	0.8	0.1	0.6	0.4	-0.9	-0.5
Pulse rate, automated reading	0.5	1.8	9.0	-0.4	-0.0	0.6	1.8	0.4	1.1	0.5	0.3	3.0	-0.2	2.2	2.0	-0.2
Alcohol intake frequency.	0.5	1.2	3.6	1.3	-1.4	0.3	-0.8	1.1	-0.8	0.5	0.4	1.1	1.5	1.4	-0.5	1.9
Comparative height size at age 10	0.5	2.8	10.9	1.6	-0.6	0.8	-1.8	1.9	-0.9	0.8	-0.3	-1.2	3.3	-1.1	-1.2	3.2
Number of full sisters	0.5	0.6	3.1	-0.1	0.7	-0.4	0.2	0.5	1.0	0.6	1.8	1.4	0.6	0.1	0.6	-0.2
Suffer from ‘nerves’	0.5	0.8	2.9	1.2	-0.1	1.4	-0.4	0.9	-1.1	0.6	-0.1	1.7	1.0	0.4	-0.1	0.6
Overall health rating	0.5	1.1	3.1	-0.1	0.7	1.5	-0.0	0.4	0.4	1.0	0.7	1.5	1.8	1.4	0.5	1.5
Chest pain or discomfort	0.5	0.8	2.0	-0.7	0.6	0.4	1.0	0.1	1.4	1.2	0.7	1.4	0.4	0.6	1.3	-0.1
Leg fat-free mass (right)	0.5	2.8	10.9	2.4	2.1	1.2	0.6	1.6	0.9	1.1	1.3	0.2	3.3	1.7	-1.8	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.5	0.9	0.3	1.6	-0.0	1.0	-0.6	0.5	0.2	0.8	1.2	0.9	-0.2	0.5
Back pain experienced in last month	0.5	0.8	3.3	1.8	-0.0	1.2	0.1	1.5	0.3	0.7	0.5	-0.4	1.1	0.6	-0.3	0.2
Leg predicted mass (right)	0.5	2.9	10.8	2.5	2.2	1.3	0.7	1.6	1.0	1.1	1.3	0.2	3.3	1.7	-1.8	0.8
Average weekly champagne plus white wine intake	0.5	0.7	2.5	-0.8	-0.7	-0.7	-0.5	-0.6	-0.9	-0.7	-1.6	1.0	-0.7	-0.9	0.6	0.0
Ever taken oral contraceptive pill	0.5	0.5	2.1	1.5	-0.4	-0.6	-0.5	0.3	-1.3	0.2	0.4	-0.1	-0.4	-0.1	-0.9	-1.0
Financial situation satisfaction	0.5	0.7	2.4	-0.7	0.2	-0.4	0.8	0.4	1.0	0.2	-0.0	1.4	0.4	-1.3	1.6	0.4
Eye problems/disorders: Glaucoma	0.5	0.6	1.7	0.4	0.8	0.6	1.3	0.9	1.2	0.7	1.0	-0.4	-0.0	0.1	0.9	-0.8
Medication: Lisinopril	0.5	0.7	1.7	-1.1	-1.2	-0.6	-0.9	-0.9	-0.8	-1.3	-0.7	0.7	0.0	-0.0	0.4	1.1
Irritability	0.5	0.9	4.2	1.5	0.1	0.8	0.4	1.0	-0.4	0.1	-1.1	0.3	-0.9	-0.4	0.9	-2.0
Age started oral contraceptive pill	0.5	0.7	2.4	-0.8	-0.2	-0.2	0.7	0.2	-0.0	0.4	-0.1	0.9	0.2	1.6	1.5	1.2
Prostate Cancer	0.4	0.6	2.4	0.2	-0.5	-0.4	-0.0	1.0	-0.2	0.4	-0.5	1.6	0.6	-0.6	1.4	0.7
Age at First Birth	0.4	0.5	2.0	0.9	-0.7	-1.0	-0.6	0.5	-1.1	-0.1	-1.4	-0.6	-0.4	0.0	-0.4	-0.3
Blood Red Count	0.4	3.5	9.4	1.2	1.3	2.0	1.6	2.9	1.1	1.9	-0.7	3.1	2.2	-0.3	2.4	1.2
Height	0.4	8.4	31.9	3.5	-0.4	1.3	-3.1	2.9	-1.7	2.4	0.6	-1.4	5.7	-1.2	-2.7	5.1
Waist Hip Ratio (WHR)	0.4	1.7	5.6	-1.1	-0.4	0.4	-2.1	-1.8	-1.5	-0.8	-2.4	-0.8	0.9	-0.3	-0.8	1.4
Systolic Blood Pressure	0.4	2.2	6.2	0.0	0.9	2.4	0.3	0.9	-0.1	0.9	1.8	1.9	2.4	1.3	0.8	2.5
Smoking Status	0.4	1.0	4.9	1.4	0.3	-0.9	1.2	0.7	0.7	1.1	-0.4	0.2	-1.1	0.9	-0.4	-2.2
Hand grip strength (left)	0.4	1.2	6.2	-0.5	0.3	1.0	-0.4	0.3	0.2	-1.0	0.1	0.2	2.5	-1.0	-0.4	2.2
Medication for hormone replacement therapy	0.4	0.5	2.1	-1.0	-0.7	-0.3	-0.9	-0.6	-0.8	-1.5	-0.5	0.1	0.0	-0.6	0.1	0.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.9	-1.3	-0.0	-0.5	0.6	-0.7	1.4	0.1	0.9	-0.7	-0.2	0.4	-0.1	0.2
Trunk fat mass	0.4	1.6	7.8	0.7	1.2	1.7	-0.3	1.2	0.4	0.4	0.7	1.0	2.8	1.5	-0.6	1.5
Had other major operations	0.4	0.4	1.8	0.0	0.2	1.3	0.1	0.8	-0.0	0.3	0.6	-0.3	1.0	-0.5	0.5	1.0
Financial difficulties in last 2 years	0.4	0.5	1.7	0.8	0.4	1.3	0.9	0.5	0.5	0.8	0.3	0.7	0.3	-0.3	-0.4	-1.3
Time employed in main current job	0.4	0.5	1.3	0.7	-1.0	0.7	-0.6	0.6	-0.3	0.5	0.4	0.2	1.0	0.4	-0.5	1.1
Mouth/teeth dental problems: Dentures	0.4	0.7	3.1	-1.5	0.3	-0.1	-0.4	-0.3	0.2	0.1	1.0	0.3	1.3	0.5	0.5	1.8
Standing height	0.4	4.1	8.1	2.8	-0.8	0.1	-2.8	1.5	-1.6	0.5	-1.1	-2.8	2.8	-1.9	-2.7	1.9
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.6	-0.4	-0.7	-0.7	-0.5	-0.3	-0.4	-0.5	-1.3	1.0	-0.5	-0.6	0.7	-0.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.1	-0.5	-0.1	-1.1	0.8	-0.5	1.3	-0.4	0.6	0.2	-1.1	-0.5	0.1	-1.4
Body fat percentage	0.4	1.6	4.9	-0.0	1.3	2.0	0.3	1.0	1.0	0.5	1.1	1.6	2.2	1.8	0.3	1.3
Exposure to tobacco smoke outside home	0.4	0.5	3.1	-0.6	0.4	-0.7	0.2	-0.5	0.2	-0.2	-0.0	0.2	1.1	0.7	0.0	1.8
Number of children fathered	0.4	0.5	2.1	-0.3	0.7	-0.3	0.9	-0.2	1.0	-0.2	0.1	0.9	-0.3	1.4	-0.5	-0.8
Mean time to correctly identify matches	0.4	0.7	3.9	-0.7	-0.9	-0.7	-1.0	0.2	-0.8	0.4	-0.7	-0.6	0.6	0.8	0.1	2.0
Knee pain experienced in last month	0.4	0.6	2.4	-0.2	1.0	1.5	0.4	0.2	0.9	0.4	0.9	0.8	0.7	1.1	0.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	3.6	1.9	0.0	-0.0	-0.2	1.1	-0.4	0.3	-0.3	-1.7	1.2	0.6	-0.9	0.4
Commuting to job workplace: Walk	0.4	0.5	1.4	0.6	-0.7	-1.1	0.1	0.2	-0.7	1.2	0.3	0.8	-0.8	0.2	0.5	-0.7
High cholesterol (Self-reported)	0.4	0.7	2.4	-0.8	-1.4	-0.3	-1.5	-0.5	-0.8	-0.5	-1.0	-0.9	-0.5	-0.6	-1.0	0.5
Fractured/broken bones in last 5 years	0.4	0.6	1.2	0.9	-0.9	0.1	0.6	0.8	-0.2	0.7	-0.6	0.0	-0.9	1.0	1.0	-1.1
Myopia	0.4	0.5	2.3	0.5	-0.8	-0.2	-0.7	0.4	-1.2	0.7	-0.1	0.3	0.7	0.2	0.7	1.5
Basal cell carcinoma (self-reported)	0.4	0.5	3.2	0.1	-0.8	-0.8	-1.0	-0.3	-0.4	-0.5	0.2	-1.8	-0.1	0.3	-0.8	-0.2
Heart attack/myocardial infarction (self-reported)	0.4	0.6	2.7	0.4	0.4	0.6	-0.8	0.1	-0.2	0.3	-0.5	1.2	1.6	-0.2	-0.6	1.0
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	2.0	0.5	0.4	0.5	1.4	0.9	1.1	0.7	0.2	0.5	-0.4	0.5	1.1	-0.4
LDL Cholesterol	0.3	0.4	1.2	-0.2	0.4	1.1	0.9	0.1	1.0	0.3	0.6	0.2	-0.7	0.5	1.1	-0.4
Allergy or Eczema	0.3	0.7	1.6	-0.7	0.2	-1.1	0.8	-0.3	1.0	1.3	0.7	-1.2	-1.1	-0.2	0.6	-0.4
Lung FEV1/FVC ratio	0.3	1.7	12.3	0.1	0.5	-2.5	-0.6	-0.4	-0.7	-0.7	0.1	-3.5	-0.5	-0.9	-0.6	-1.0
Number of treatments/medications taken	0.3	0.5	2.0	1.0	-0.2	0.3	-0.9	0.4	-1.1	1.0	0.2	1.4	0.3	0.5	-0.5	-0.5
Average weekly spirits intake	0.3	0.3	2.4	-0.1	-0.1	-0.3	0.1	0.3	-0.0	-0.0	0.3	0.9	0.5	1.5	-0.3	0.7
Ever had hysterectomy (womb removed)	0.3	0.4	2.3	-0.4	-0.1	-0.6	-0.2	-0.3	-0.6	-0.1	-0.5	-0.5	0.3	0.9	-0.4	1.5
Angina	0.3	0.4	1.0	-0.7	0.6	0.4	-0.7	-0.3	-0.1	-0.2	0.6	-1.0	0.6	-0.0	-0.5	1.0
Impedance of leg (right)	0.3	1.4	4.4	-0.7	-1.8	-0.5	-1.3	0.1	-0.9	-0.3	-1.2	-1.8	-1.3	-2.1	1.1	0.3
Townsend deprivation index at recruitment	0.3	0.4	1.3	0.7	0.3	0.1	0.3	0.7	0.2	1.1	1.1	-0.2	0.1	0.8	0.3	-0.5
Taking other prescription medications	0.3	0.4	1.9	0.5	0.5	0.9	-0.1	0.5	0.4	1.1	0.5	1.4	0.5	0.3	-0.1	-0.5
Qualifications: CSEs or equivalent	0.3	0.5	1.5	0.7	0.4	0.4	1.2	0.4	0.6	0.1	0.4	0.3	-0.4	1.2	0.3	-1.1
Multivitamins +/- minerals	0.3	0.4	1.8	0.0	-1.0	-1.3	-0.1	0.2	-0.7	0.0	0.1	0.2	-0.8	0.4	1.1	0.1
Sitting height	0.3	2.5	6.5	2.5	1.8	0.7	-0.7	1.8	0.3	0.6	1.4	-1.9	2.5	-0.0	-2.1	1.3
Chronic bronchitis/emphysema (father)	0.3	0.3	1.0	0.4	-0.1	0.6	-1.0	0.3	-0.3	-0.4	0.1	-0.8	1.0	0.4	-0.4	0.7
Prospective memory result	0.3	0.4	1.6	-1.3	-0.0	-0.6	-0.1	-0.7	0.6	-0.8	-0.8	-0.5	-0.7	0.0	-0.2	0.4
Hair/balding pattern: Pattern 4	0.3	0.8	2.2	0.1	0.0	0.3	-0.6	0.3	-0.7	0.4	1.3	1.3	1.5	1.1	-0.1	1.4
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	1.8	0.5	0.5	-0.6	1.3	0.7	1.3	0.4	0.9	-0.8	-0.5	0.3	0.4	-0.6
Glaucoma (self-reported)	0.3	0.3	1.9	-0.5	0.1	-0.5	0.6	0.6	0.8	0.4	0.5	-0.1	0.0	0.0	1.4	0.1
Birth weight	0.3	0.7	2.0	0.5	-0.3	1.3	-1.2	0.2	-1.4	-0.3	0.2	-0.0	1.2	-0.5	-1.0	0.0
Migraine (self-reported)	0.3	0.3	1.0	0.3	-0.6	-0.8	-0.5	-0.5	-1.0	-0.2	0.2	-0.6	-0.5	-0.2	-1.0	-0.6
Medication: Seretide 50 evohaler	0.3	0.4	1.4	0.7	0.7	0.3	0.2	0.5	0.3	0.4	1.2	-0.7	0.8	0.1	-0.9	-0.1
Medication: Aspirin	0.3	0.4	1.6	0.3	-0.9	0.0	-1.1	-0.2	-1.2	-0.1	-0.3	0.0	0.4	1.0	-0.8	-0.0
Medication: Aspirin	0.3	0.4	1.5	0.1	-0.8	0.2	-0.9	-0.5	-1.2	-0.1	-0.5	0.1	0.3	0.9	-0.6	0.3
Medication: Bendroflumethiazide	0.3	0.5	4.8	-0.3	-0.4	2.2	-0.7	-0.5	-0.1	-0.1	0.7	0.4	0.0	-0.1	-0.4	0.3
Medication: Atorvastatin	0.3	0.4	1.4	0.5	-0.1	-0.4	-0.8	-0.1	-0.9	-0.1	0.3	-1.1	0.2	-0.4	-1.2	-0.0
Number of operations (self-reported)	0.3	0.5	1.5	0.9	0.7	1.0	-0.1	1.2	-0.3	0.5	0.6	0.4	1.2	-0.1	-0.4	0.3
Unable to work because of sickness or disability	0.3	0.4	1.5	0.9	0.2	0.8	-0.1	0.8	-0.6	0.5	0.1	1.2	0.3	0.3	0.4	-0.5
Reaction Time	0.2	0.4	1.2	-0.6	-1.0	-1.1	-0.7	-0.1	-0.4	0.1	-1.1	-0.7	-0.4	0.2	0.1	0.8
Body Mass Index (BMI) (2010)	0.2	0.2	1.4	-0.2	0.1	-0.2	0.1	-0.2	-0.2	-0.3	-0.2	1.2	0.5	0.7	-0.1	0.4
HDL Cholesterol	0.2	0.3	0.9	0.7	-0.2	0.5	-0.2	1.0	-0.7	1.0	0.2	0.2	0.2	-0.1	0.8	0.1
Hypothyroidism (self reported)	0.2	0.5	1.8	1.3	0.4	0.3	0.3	0.9	0.7	0.2	-0.3	1.2	0.1	0.4	-0.7	-1.1
Lung FVC	0.2	1.2	3.8	1.0	-0.7	0.1	-1.9	0.6	-1.6	-1.0	-1.0	-0.5	0.8	-0.8	-1.9	0.1
Tanning	0.2	2.3	7.6	-0.6	0.2	-1.0	-2.0	-0.9	-0.9	-2.2	-1.2	-2.8	0.2	-2.4	-1.6	1.0
Medication: Metformin	0.2	0.3	1.4	-0.9	0.3	0.1	0.3	-0.5	0.1	0.1	1.2	-0.5	-0.2	0.8	0.7	0.1
Pack years adult smoking proportion	0.2	0.4	1.8	0.1	0.6	-0.2	-0.4	-0.1	0.0	-0.3	1.2	-1.3	0.3	0.1	-0.7	0.0
Trunk fat percentage	0.2	0.9	3.6	-0.2	0.4	1.3	-0.5	0.6	0.0	-0.1	0.2	1.4	1.9	1.4	-0.2	1.4
Serious illness, injury or assault to yourself	0.2	0.2	0.5	0.6	0.0	0.3	-0.3	0.7	-0.4	0.6	-0.2	0.5	0.7	0.7	-0.2	0.1
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.6	0.0	0.5	-0.3	0.9	0.2	0.7	1.3	0.9	-0.7	-0.5	-0.1	1.0	-0.4
Medication: Levothyroxine sodium	0.2	0.3	1.2	0.6	-0.4	0.2	-0.4	0.2	-0.3	-0.7	-0.1	-0.1	-0.6	-0.3	-1.1	-0.8
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.9	0.6	-0.3	-0.7	0.1	0.6	-0.1	-0.2	-0.7	1.0	-0.0	0.9	0.5	-0.1
Alcohol intake versus 10 years previously	0.2	0.4	1.0	0.9	0.4	0.4	0.5	1.0	0.7	0.1	0.5	-0.6	0.8	0.3	0.5	0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.4	1.2	0.3	0.1	0.2	0.6	0.4	-0.4	0.2	0.8	0.2	0.7	-0.9	-0.8
Medication: Blood pressure	0.2	0.4	2.5	-0.1	-0.0	0.6	-0.3	-0.3	-1.1	0.1	-0.4	1.6	0.6	0.6	0.1	0.3
Angina (self-reported)	0.2	0.3	0.6	-0.4	0.8	0.5	-0.4	-0.1	0.1	0.0	0.7	-0.8	0.6	0.1	-0.5	0.7
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.6	0.2	-0.3	-0.0	0.1	-0.2	-0.2	-0.7	-0.6	-0.7	-0.4	-0.6	-0.2	-0.6
Loneliness, isolation	0.2	0.2	1.0	0.0	-0.6	0.4	-0.1	0.5	-0.6	-0.1	0.3	0.6	-0.1	1.0	0.6	0.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.9	0.6	-0.1	-0.0	0.3	0.6	0.1	0.7	-0.3	0.2	0.2	1.0	0.8	0.6
Pack years of smoking	0.2	0.3	1.3	-0.4	0.3	-0.1	-0.7	-0.2	-0.1	-0.5	1.1	-0.9	0.3	0.0	-0.4	0.6
Blood Eosinophil Count	0.1	0.6	2.8	-0.6	0.8	-0.1	0.5	-0.2	1.5	0.5	1.7	-0.3	0.3	0.2	-0.0	0.8
Supplements: Glucosamine	0.1	0.1	0.3	-0.4	-0.4	0.3	0.1	-0.3	0.1	-0.5	-0.1	-0.1	-0.6	-0.3	0.2	-0.3
Allergy	0.1	0.3	1.2	-0.1	0.1	0.6	0.0	0.2	-0.0	-0.8	-0.3	0.5	1.1	0.2	0.2	1.1
Peak expiratory flow (PEF)	0.1	0.3	1.0	0.0	0.4	-0.5	-0.0	0.3	0.7	-0.8	0.5	-1.0	0.2	-0.6	-0.6	-0.2
Leg pain on walking	0.1	0.1	0.8	0.5	0.1	-0.9	-0.1	0.5	0.1	0.0	0.0	0.1	0.4	0.3	-0.1	0.1
Alcohol drinker status: Never	0.1	0.2	1.1	-0.2	-0.2	-0.1	0.6	-0.2	0.1	-0.1	0.5	-0.3	-0.3	1.1	-0.2	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.6	1.8	0.6	0.5	0.6	0.7	1.0	0.3	0.5	0.4	1.3	0.9	0.4	1.3	0.7

Hub : Genes

RPA1

Models

Trait associations