Hub : Genes

KLF11

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.303	0.0990	6.9e-03	0.003	NA	-0.002	NA	0.019	2.6e-01	NA	3.8e-01	NA	8.7e-02
2	GTEx	Brain Cortex	0.422	0.1140	5.4e-03	0.018	NA	0.011	NA	0.001	1.0e-01	NA	1.6e-01	NA	3.0e-01
3	GTEx	Liver	0.596	0.1230	1.2e-03	-0.003	NA	0.135	NA	0.069	4.1e-01	NA	1.4e-04	NA	5.6e-03
4	YFS	Blood	0.206	0.0272	0.0e+00	0.070	0.122	0.142	0.161	0.115	6.3e-22	8.5e-38	4.6e-44	2.1e-50	1.8e-35
5	TCGA	Thyroid Carcinoma	0.172	0.0500	7.0e-09	0.102	0.094	0.084	NA	0.087	3.7e-10	2.1e-09	1.4e-08	NA	8.7e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.6	2.4	0.2	1.6	-0.6	-0.2	-0.6
Bipolar Disorder or Schizophrenia	0.5	1.2	2.9	1.7	0.7	0.9	0.9	-1.1
Depressed Affect (Nagel 2018)	2.1	4.4	11.3	2.6	3.4	-1.1	1.5	-0.4
Depression (Nagel 2018)	0.5	0.8	2.4	0.9	1.5	-0.1	0.6	0.6
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.8	-1.3	1.0	0.5	0.2	-0.5
Neuroticism (Nagel 2018)	1.8	4.3	13.0	2.1	3.6	-1.8	0.9	-0.4
Schizophrenia (2018)	0.9	1.9	3.9	2.0	-0.3	1.6	1.3	-0.9
Schizophrenia vs Biploar Disorder	0.4	0.5	1.6	0.3	-1.3	-0.0	0.1	-0.8
Worry (Nagel 2018)	0.9	2.0	5.5	-0.1	2.3	-2.0	-0.0	-0.5
Alzheimer’s Disease (in mother)	1.6	1.9	5.3	1.4	0.2	-0.6	1.4	-2.3
Alzheimer’s Disease (in father)	0.5	0.5	1.4	-0.6	-1.2	-0.2	-0.1	0.9
Alzheimer’s Disease (including proxy)	0.7	1.0	1.8	0.5	-1.3	-0.9	0.7	-1.2
Crohns Disease (2017)	0.2	0.5	1.1	1.0	-0.4	-0.9	0.4	0.4
Irritable Bowel Disease (IBD)	0.6	1.3	5.9	2.4	0.8	0.3	0.0	0.1
Ulcerative Colitis (UC)	1.2	2.2	6.8	2.6	1.4	1.4	0.1	-0.2
Major Depression (MDD)	1.4	1.7	3.2	1.2	1.8	-0.3	1.3	-1.5
Reaction Time	0.1	0.1	0.5	0.1	-0.2	-0.2	-0.7	0.0
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.7	-0.5	0.9	-0.0	0.0	-0.5
Breast Cancer	0.7	1.7	3.8	-2.0	-1.1	-0.9	0.9	-1.4
Ovarian Cancer	0.5	0.7	2.0	-1.4	-0.6	-1.0	0.0	-0.4
Prostate Cancer	0.7	0.9	3.3	0.9	0.4	-0.7	-1.8	-0.1
Age at First Birth	1.3	1.9	3.2	1.4	1.8	-1.1	0.5	-1.6
Bipolar Disorder (2011)	0.1	0.1	0.4	0.0	0.0	0.0	0.0	-0.6
Body Mass Index (BMI) (2010)	1.0	1.4	3.1	1.3	-1.8	1.2	0.7	-0.2
Coronary Artery Disease (CAD)	0.1	0.1	0.2	-0.1	0.2	0.5	0.2	0.1
Crohns Disease (2012)	1.9	3.1	6.0	-1.8	-2.5	-2.4	0.2	-0.6
Mean Putamen Volume	1.2	1.3	2.4	-0.6	1.3	-1.2	0.8	-1.5
Fasting Glucose	0.8	1.0	2.2	-0.5	-0.8	-1.2	-0.3	-1.5
HbA1C	1.1	1.3	2.2	-0.8	-1.2	1.0	1.0	-1.5
HDL Cholesterol	0.5	0.8	1.3	-0.7	-1.0	-0.3	-1.1	1.1
LDL Cholesterol	0.1	0.1	0.3	0.6	-0.0	0.5	-0.2	0.3
Lupus	0.5	0.7	3.1	0.1	-0.5	0.2	0.6	-1.8
Neuroticism (2016)	0.5	0.7	0.9	0.9	0.8	-0.8	0.7	-0.9
Primary Biliary Cirrhosis	0.4	0.6	1.8	0.3	0.2	0.5	-0.8	1.3
Rheumatoid Arthritis	0.7	1.0	2.4	0.5	-1.5	1.2	0.8	0.1
Schizophrenia (2014)	0.4	0.9	1.7	1.0	-0.2	1.3	1.3	0.1
Triglycerides	0.9	1.4	3.3	1.8	0.5	1.6	0.2	0.9
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.6	0.2	0.4	0.2	0.1	-0.8
Ulcerative Colitis	0.5	0.8	2.1	1.1	0.5	1.4	-0.1	0.6
Blood Eosinophil Count	0.4	2.9	8.7	-0.2	-3.0	-1.9	-0.9	1.1
Blood Platelet Count	0.3	2.9	7.8	-0.9	-2.8	0.7	-2.3	0.4
Blood Red Count	0.2	2.1	6.0	2.4	1.3	0.3	0.5	-1.5
Blood White Count	0.9	6.3	9.4	-2.5	-2.7	-0.7	-3.1	2.8
Heel T-Score	1.1	8.8	19.3	-4.4	-4.2	-0.0	-1.9	1.9
BMI	0.5	2.8	5.4	-0.2	-2.3	1.4	-1.9	1.8
Height	2.1	40.5	84.3	9.2	8.6	4.4	3.3	-3.8
Waist Hip Ratio (WHR)	0.4	1.7	4.3	1.3	2.1	1.0	-1.2	0.4
Systolic Blood Pressure	0.7	3.4	6.3	-2.5	-1.5	-0.7	-1.6	2.4
Smoking Status	0.7	1.7	3.7	0.2	-1.7	-0.1	-1.9	1.3
Allergy or Eczema	0.4	1.2	3.5	-0.5	0.8	-1.9	0.3	-1.1
Cardiovascular Disease	0.0	0.1	0.1	0.4	0.3	-0.3	0.4	0.2
Hypothyroidism (self reported)	0.7	1.6	3.6	0.2	1.7	0.5	1.9	-1.1
Respiratory disease	0.5	1.1	3.4	1.9	0.4	-0.7	-0.3	1.2
Type 2 Diabetes (T2D) (2018)	1.8	3.3	5.2	-1.9	0.6	-2.3	-1.9	1.9
Lung FEV1/FVC ratio	0.6	3.0	8.6	-1.9	-0.9	-0.5	-2.9	1.2
Lung FVC	0.9	4.5	8.0	1.6	1.6	1.9	2.5	-2.8
Neuroticism	1.9	4.5	12.1	2.7	3.5	-1.2	1.0	-0.7
Chronotype (morning person)	0.3	0.7	1.4	1.2	1.2	0.4	0.4	0.6
Hair Pigment	0.1	3.2	7.5	-1.2	-1.6	0.8	-2.7	1.9
Tanning	0.0	0.5	1.0	0.2	0.9	-0.6	0.5	-1.0
Hand grip strength (left)	0.4	0.9	3.1	-0.8	-0.5	0.8	-0.2	1.8
Number of treatments/medications taken	0.5	0.8	1.6	0.6	-0.8	-1.3	-0.6	-1.1
Average weekly spirits intake	0.4	0.5	1.1	-0.4	-0.9	1.1	0.3	0.3
Sensitivity / hurt feelings	0.3	0.6	1.6	1.3	0.7	-0.6	0.3	-0.5
Frequency of depressed mood in last 2 weeks	1.5	2.1	5.0	1.6	2.2	-1.4	0.8	-0.2
Hearing difficulty/problems: Yes	0.4	0.6	1.2	-0.0	0.4	0.8	-1.1	1.1
Relative age of first facial hair	1.3	2.7	7.8	1.9	2.8	-1.3	0.3	-0.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.9	-0.4	0.5	-1.4	-0.6	-0.7
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	-1.0	-0.7	0.0	-0.3	-0.4
Ever had hysterectomy (womb removed)	0.4	0.5	1.9	-0.5	-0.3	-1.4	0.0	-0.2
Systolic blood pressure, automated reading	1.1	3.3	6.3	-2.5	-1.9	-0.6	-1.9	1.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.4	1.2	-0.5	-0.4	0.1	-0.4
Angina	0.5	0.7	1.4	0.3	-0.9	-0.9	0.7	-1.2
Medication for hormone replacement therapy	0.6	0.7	1.7	-1.1	0.6	-1.3	-0.1	0.3
Vitamin and mineral supplements	0.6	0.8	2.0	0.4	-1.0	-0.1	-1.4	0.9
Supplements: Zinc	0.2	0.2	0.5	-0.4	-0.1	-0.6	-0.1	-0.7
Medication: Co-codamol	1.1	1.3	4.9	-0.5	0.1	-2.2	-1.1	0.4
Medication: Metformin	1.0	1.4	2.9	-0.8	1.7	-1.7	-0.4	0.5
Diabetes (father)	0.7	0.8	1.8	-1.2	0.1	-0.4	-0.9	1.3
Diabetes (mother)	0.9	1.2	2.1	0.7	1.5	-1.4	-0.5	-0.9
Severe depression (siblings)	0.6	0.6	1.1	0.4	0.2	0.9	-1.1	1.0
Pack years adult smoking proportion	0.2	0.3	1.0	0.0	-1.0	0.2	0.4	-0.4
Impedance of leg (right)	0.3	1.3	2.7	1.0	1.0	1.6	1.0	-0.7
Leg fat-free mass (left)	0.6	3.0	7.8	2.8	2.2	1.4	0.1	-0.5
Trunk fat percentage	0.2	0.8	2.3	0.4	-1.5	0.3	-1.0	-0.7
Hand grip strength (right)	0.1	0.3	0.6	0.2	-0.5	0.8	-0.2	0.8
Townsend deprivation index at recruitment	0.5	0.7	2.6	-0.1	-0.6	-0.4	-0.6	1.6
Current tobacco smoking	1.2	2.0	3.5	-1.2	-1.7	0.8	-1.2	1.9
Average weekly fortified wine intake	0.7	0.8	2.0	-0.4	-0.6	-0.6	-1.4	1.1
Maternal smoking around birth	0.3	0.4	1.5	1.2	0.2	-0.4	0.1	-0.4
Fed-up feelings	1.1	2.0	4.0	1.7	2.0	-1.0	1.2	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.4	0.6	1.2	0.1	0.5	0.9
Relative age voice broke	1.1	1.7	5.6	-0.2	2.4	-0.8	0.9	1.2
Taking other prescription medications	0.9	1.3	3.0	1.7	1.3	-1.4	0.2	0.1
Age when periods started (menarche)	2.2	5.2	16.8	2.9	4.1	-0.7	0.4	-0.2
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	2.6	-1.4	-1.6	-1.6	-0.7	0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	5.4	-1.9	-1.0	0.7	-2.3	0.7
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.8	-0.3	0.2	0.8	-1.3	1.2
Qualifications: CSEs or equivalent	0.4	0.5	1.4	0.1	-0.5	-0.5	1.2	-0.9
Serious illness, injury or assault to yourself	0.4	0.5	1.9	0.5	1.4	0.4	-0.2	-0.6
High blood pressure	0.1	0.4	1.3	-0.4	-0.4	-1.1	0.5	-0.0
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.4	-0.3	0.2	-1.0	0.1	-1.2
Multivitamins +/- minerals	1.4	1.8	3.7	0.3	1.6	-0.3	1.6	-1.9
Stomach or abdominal pain in last month	0.1	0.1	0.4	0.2	0.1	0.1	-0.2	0.7
Supplements: Glucosamine	1.3	1.6	2.7	1.0	1.4	1.1	1.2	-1.6
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	3.6	0.2	1.1	-1.0	0.1	-1.9
Medication: Atenolol	1.0	1.3	3.5	-0.9	-1.9	-0.4	-1.0	1.0
Medication: Levothyroxine sodium	0.2	0.4	0.9	0.1	0.7	0.7	1.0	-0.4
Sitting height	1.2	8.7	14.1	3.7	3.8	3.8	1.0	-0.7
Chronic bronchitis/emphysema (father)	0.9	1.1	1.9	-1.1	-0.6	-1.4	1.2	-0.8
High blood pressure (mother)	0.3	0.5	1.4	-0.5	-0.1	-1.2	0.2	-0.8
Body mass index (BMI)	0.3	1.2	4.4	-0.0	-2.1	-0.3	-1.1	0.1
Impedance of leg (left)	0.3	1.2	2.2	0.9	1.2	1.5	1.1	-0.6
Leg predicted mass (left)	0.6	3.2	8.6	2.9	2.3	1.4	0.1	-0.5
Trunk fat mass	0.2	1.0	2.5	1.6	-0.7	1.0	-0.8	-0.6
Waist circumference	0.2	0.7	2.8	1.7	0.1	0.3	-0.5	-0.6
Number of incorrect matches in round	0.9	1.6	4.6	2.1	0.1	1.6	0.7	0.3
Past tobacco smoking	0.8	1.5	3.3	-0.8	0.6	-1.5	1.8	-1.0
Alcohol usually taken with meals	0.4	0.6	1.5	-0.7	1.2	0.3	0.0	-1.0
Nervous feelings	1.5	2.7	10.5	-0.3	3.2	-1.6	-0.5	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.3	0.5	1.5	-1.4	-0.4	1.1
Hearing difficulty/problems with background noise	0.5	0.8	1.3	1.1	0.9	-0.6	0.9	-0.8
Hair/balding pattern: Pattern 2	0.7	0.9	3.4	-1.8	-0.9	0.1	0.1	-0.5
Had menopause	0.8	1.0	4.4	-0.1	-0.7	2.1	-0.4	0.1
Had other major operations	4.7	5.7	16.5	1.4	2.5	-1.1	4.1	-1.6
Forced vital capacity (FVC)	2.6	10.1	18.5	4.2	4.3	3.2	1.3	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.6	5.6	-2.4	-2.0	0.6	-1.6	0.8
Ever unenthusiastic/disinterested for a whole week	2.4	3.0	8.0	1.9	2.8	0.3	0.2	-1.7
Qualifications: None of the above	1.1	2.3	5.4	0.2	-0.4	1.3	-2.3	2.1
Financial difficulties in last 2 years	0.3	0.5	0.9	-0.6	-1.0	-0.7	-0.2	0.7
Mouth/teeth dental problems	0.3	0.5	1.0	-0.6	0.1	1.0	-0.7	0.7
Heart attack	0.3	0.4	0.8	0.9	-0.4	-0.0	-0.9	0.4
Allergy	0.3	0.6	2.5	-0.4	-0.1	1.6	-0.2	0.5
Pain all over the body in last month	0.7	0.7	2.4	-0.1	-0.2	-1.5	0.4	-1.0
Diabetes (self-reported)	1.2	1.8	5.1	-0.3	2.3	-1.7	-0.3	1.1
Hayfever/allergic rhinitis (self-reported)	2.8	3.7	9.5	-2.5	-1.5	-3.1	-0.3	-0.8
Medication: Ramipril	0.3	0.4	1.1	-0.3	-0.3	-1.0	-0.6	0.5
Medication: Simvastatin	1.5	2.3	4.7	-0.6	-1.8	0.8	-1.5	2.2
Fluid intelligence score	0.1	0.2	0.4	-0.7	-0.3	0.4	-0.5	-0.4
Illnesses of siblings	0.5	0.7	1.2	0.9	-0.3	1.1	-0.2	-1.1
Neuroticism score	1.2	2.4	6.0	1.5	2.5	-1.9	0.6	-0.4
Weight	0.5	2.4	7.7	2.8	0.9	1.7	-0.1	-0.9
Impedance of arm (right)	0.3	1.2	4.2	-2.0	-1.2	-0.1	-0.2	-0.4
Arm fat percentage (right)	0.8	3.1	12.0	-1.1	-3.5	-0.5	-1.5	0.2
Trunk fat-free mass	1.5	8.6	20.5	4.5	3.5	2.9	1.2	-0.8
Hip circumference	0.2	1.0	2.5	1.5	-0.2	0.0	0.7	-1.6
Time employed in main current job	0.8	1.0	2.2	0.9	0.8	-1.5	-1.0	-0.5
Alcohol intake versus 10 years previously	0.4	0.6	1.1	1.0	-0.4	1.1	0.8	0.2
Father’s age at death	0.6	0.7	2.6	0.2	1.0	0.0	1.6	0.4
Worrier / anxious feelings	1.5	2.8	7.8	1.3	2.8	-1.1	0.7	-1.7
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	3.6	1.9	0.6	-0.3	-0.2	-0.0
Falls in the last year	0.9	1.2	3.4	-0.1	-1.8	0.0	-0.9	1.3
Hair/balding pattern: Pattern 3	0.8	1.2	3.0	0.7	1.1	-0.6	1.0	1.7
Number of live births	0.4	0.5	1.8	0.4	0.6	1.4	0.6	-0.1
Forced expiratory volume in 1-second (FEV1)	1.7	5.7	13.3	3.0	3.6	2.5	-0.3	-0.4
Pulse rate	0.7	1.1	3.9	-0.1	0.9	2.0	0.5	0.8
Happiness	1.2	1.5	2.8	-1.6	1.7	0.2	0.2	1.4
Noisy workplace	1.6	1.9	3.2	-1.8	-1.3	1.4	-1.2	1.2
Qualifications: A levels/AS levels or equivalent	0.6	1.3	3.2	0.2	1.8	-0.2	1.3	-1.3
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.1	-0.2	-0.5	-0.1	-1.0	1.1
Mouth/teeth dental problems: Dentures	0.4	0.6	1.5	1.2	0.2	0.0	1.2	-0.3
Asthma	0.6	1.3	4.2	2.1	0.0	-1.1	-0.4	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	2.0	0.4	0.0	-1.4	0.2	-0.8
Medication: Cholesterol lowering	0.9	1.4	4.3	-0.1	-0.7	0.6	-2.1	1.4
Depression (self-reported)	1.4	1.7	3.6	1.1	1.6	-1.9	-0.6	-0.8
Medication: Lansoprazole	2.1	2.4	6.1	-2.5	-1.4	-1.7	0.5	0.8
Prospective memory result	1.3	1.6	4.8	0.4	1.3	-0.9	0.7	-2.2
Lung cancer (father)	0.8	1.0	1.7	1.1	-0.4	1.1	0.7	-1.3
Illnesses of mother	0.5	0.6	1.9	0.7	-0.6	1.4	0.6	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.9	10.8	2.9	3.3	2.0	0.7	-0.9
Pulse wave Arterial Stiffness index	0.6	0.7	1.9	0.8	0.8	1.4	0.7	0.1
Impedance of arm (left)	0.1	0.5	1.1	-1.0	-0.2	0.4	0.4	-1.0
Arm fat mass (right)	0.2	0.9	3.3	0.5	-1.8	0.6	-0.8	-0.1
Trunk predicted mass	1.5	8.5	20.3	4.5	3.4	2.9	1.2	-0.8
Standing height	2.2	22.2	41.5	6.3	6.4	4.7	1.9	-1.8
Length of working week for main job	1.3	1.5	3.1	-1.2	-0.2	-1.8	-0.1	-1.7
Exposure to tobacco smoke at home	1.0	1.1	2.5	0.5	-1.6	-1.1	-0.9	0.9
Breastfed as a baby	1.1	1.3	4.7	1.0	2.2	0.9	-0.4	-0.1
Tense / ‘highly strung’	1.4	2.3	6.3	1.7	2.5	0.3	-0.1	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	4.3	0.9	2.1	-0.6	0.3	-0.9
Hair/balding pattern: Pattern 4	0.4	0.9	2.2	1.2	-0.5	0.6	-0.6	-1.5
Birth weight of first child	1.5	2.7	7.9	2.8	0.2	2.0	0.6	-1.2
Peak expiratory flow (PEF)	0.9	2.0	4.6	0.7	1.2	1.5	-2.2	1.3
Pulse wave reflection index	0.3	0.4	0.9	0.8	0.5	-0.1	1.0	-0.4
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	-0.1	-0.0	0.6	-0.7	-0.4
Loud music exposure frequency	1.1	1.2	4.4	-0.6	0.5	2.1	-0.4	0.8
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.0	-1.0	-0.4	0.0	-0.6	-0.0
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	2.9	-0.2	-0.2	-1.4	-1.7	0.6
Blood clot in the leg (DVT)	0.7	0.9	2.7	1.6	-0.8	0.8	0.7	0.3
Medication: Paracetamol	0.7	1.1	2.5	1.2	-0.5	0.2	1.1	-1.6
Headache pain in last month	0.4	0.7	2.2	0.9	-0.6	-0.1	1.5	0.6
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	3.8	-1.0	-0.6	0.4	2.0	-1.2
Glaucoma (self-reported)	0.4	0.5	2.2	0.2	-0.0	0.0	0.4	-1.5
Gout (self-reported)	0.9	1.2	5.8	-0.0	0.0	-2.4	0.1	0.6
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	3.6	0.1	1.9	-0.7	1.7	-1.4
Medication: Amlodipine	0.6	0.8	2.0	1.4	-0.0	-1.3	0.4	-0.5
Medication: Ventolin 100micrograms inhaler	1.2	1.5	4.9	1.1	-0.9	0.2	-0.9	2.2
Birth weight	0.7	1.5	2.3	1.2	1.3	1.3	0.6	-1.5
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.7	-0.8	-0.8	-0.3	-0.5	-0.5
High blood pressure (siblings)	1.8	2.6	5.7	-1.6	0.6	-2.4	-0.1	2.1
Forced vital capacity (FVC), Best measure	2.2	8.2	13.5	3.7	3.6	2.7	1.8	-2.0
Body fat percentage	0.3	1.2	4.0	0.2	-2.0	0.3	-1.3	-0.3
Leg fat percentage (right)	0.3	1.1	3.8	0.6	-2.0	0.4	-1.0	-0.2
Arm fat-free mass (right)	1.8	9.0	22.9	4.8	3.9	2.4	0.8	-0.7
Exposure to tobacco smoke outside home	1.2	1.6	6.6	0.9	-0.3	0.6	-0.1	2.6
Comparative body size at age 10	0.4	1.1	2.2	-1.5	-0.8	-1.3	-0.6	-0.6
Number of full brothers	1.2	1.5	5.1	0.8	0.3	-0.7	1.2	-2.3
Worry too long after embarrassment	0.6	1.1	3.9	0.9	2.0	-0.4	-0.5	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	7.0	1.0	2.6	-0.6	-0.2	0.1
Wheeze or whistling in the chest in last year	0.8	1.3	3.7	0.6	-1.9	-1.5	0.2	0.5
Number of children fathered	0.4	0.4	1.4	-0.1	0.1	-0.9	-0.0	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.8	-0.7	-1.3	-1.1	-0.4	0.3
Age at first live birth	0.7	1.3	3.2	0.4	1.8	-1.5	-0.3	-0.9
Pulse wave peak to peak time	0.2	0.3	0.8	-0.4	-0.2	-0.9	-0.6	-0.2
Health satisfaction	0.2	0.3	0.6	-0.0	0.8	0.3	-0.6	0.7
Shortness of breath walking on level ground	0.4	0.5	1.9	1.4	0.5	0.3	-0.2	0.5
Qualifications: College or University degree	0.3	0.9	1.8	-0.4	1.3	-1.3	-0.4	-1.0
Eye problems/disorders: None of the above	0.4	0.4	0.7	-0.1	0.9	-0.8	0.2	-0.7
Mouth/teeth dental problems: Loose teeth	1.0	1.1	2.7	-0.3	-1.2	0.9	-0.9	1.6
Emphysema/chronic bronchitis	0.4	0.4	1.1	0.3	-0.4	-0.9	-1.1	0.2
Medication for pain relief, constipation, heartburn	0.5	0.9	3.0	-0.3	1.7	0.0	0.5	1.0
Neck or shoulder pain in last month	0.5	0.8	2.7	-0.7	0.1	-1.6	0.7	-0.4
Medication: Blood pressure	0.6	1.0	2.7	1.1	0.6	-1.6	-1.0	0.3
Angina (self-reported)	0.5	0.6	1.2	0.1	-0.8	-1.1	0.5	-1.1
Migraine (self-reported)	0.3	0.4	1.0	0.5	-0.6	1.0	-0.0	-0.6
Medication: Ibuprofen	0.4	0.5	1.0	1.0	0.5	-0.8	0.0	-0.6
Medication: Allopurinol	0.9	1.2	3.3	-0.8	-0.8	-1.8	-0.9	0.9
Medication: Omeprazole	1.4	1.7	5.6	-0.1	0.3	1.0	-2.4	1.3
Medication: Seretide 50 evohaler	0.5	0.6	1.6	-0.3	-1.3	0.6	0.7	0.7
Mean time to correctly identify matches	0.1	0.2	0.8	0.3	0.2	0.3	0.1	-0.9
Heart disease (mother)	1.1	1.3	5.0	-0.7	0.9	-2.2	-0.3	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	3.9	-1.3	-0.3	-2.0	-1.8	1.8
Whole body fat mass	0.2	1.0	1.7	1.3	-1.0	0.9	-1.2	-0.3
Leg fat mass (right)	0.3	1.2	2.8	1.7	-0.9	1.2	-0.9	0.0
Arm predicted mass (right)	1.7	8.7	21.5	4.6	3.7	2.7	0.6	-0.3
Pulse rate, automated reading	0.2	0.7	1.6	-0.4	0.6	1.1	-0.2	1.3
Alcohol intake frequency.	1.2	2.7	5.8	2.1	2.4	0.9	1.6	0.1
Comparative height size at age 10	1.4	7.9	19.9	2.9	2.3	4.5	2.1	-1.1
Number of full sisters	1.5	1.9	5.4	2.3	1.3	1.0	1.1	0.2
Suffer from ‘nerves’	2.3	3.6	17.1	-1.0	0.3	-4.1	-0.2	-0.1
Overall health rating	0.7	1.5	5.1	-0.8	-0.6	-0.8	-1.0	2.3
Chest pain or discomfort	0.6	0.9	2.2	-0.8	0.1	-1.5	0.0	1.3
Had major operations	0.3	0.3	0.7	0.6	-0.2	0.8	0.6	-0.3
Age at last live birth	0.3	0.5	0.9	0.8	0.9	0.2	-0.3	-0.9
Family relationship satisfaction	0.4	0.5	1.3	-0.7	-0.0	1.1	-0.6	0.4
Leg pain on walking	0.1	0.1	0.2	-0.5	0.1	0.0	-0.3	0.5
Qualifications: NVQ or HND or HNC or equivalent	2.1	2.5	6.5	-0.1	-0.0	-1.1	2.5	-2.2
Commuting to job workplace: Car/motor vehicle	0.8	0.9	3.1	0.1	-1.2	1.8	0.2	0.2
Illness, injury, bereavement, stress in last 2 years	2.3	2.8	5.3	2.0	0.7	-0.3	2.3	-2.1
Medication: Aspirin	0.9	1.1	3.3	0.5	-1.8	0.3	-0.8	-1.2
Supplements: Vitamin C	0.2	0.2	0.6	0.4	-0.4	-0.2	-0.1	-0.8
Knee pain experienced in last month	0.9	1.4	2.9	1.7	1.4	0.0	-0.7	1.3
Hypertension (Self-reported)	0.2	0.5	1.4	-0.0	-0.3	-1.2	0.7	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	1.2	0.5	-0.1	-0.0	0.1	1.1
Illnesses of father: Heart disease	0.5	0.6	2.4	0.7	1.6	-0.4	0.2	-0.1
Illnesses of siblings: Diabetes	0.7	0.8	1.9	-0.2	0.3	0.5	-1.3	1.4
Smoking status: Previous	0.6	0.8	1.8	1.2	0.6	0.5	-1.4	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	1.7	1.3	1.2	1.2	0.9	-0.9
Whole body fat-free mass	1.2	6.9	16.7	4.1	3.3	2.4	0.8	-0.6
Leg fat-free mass (right)	0.5	2.9	6.9	2.6	2.5	1.1	0.0	-0.4
Arm fat percentage (left)	0.6	2.3	9.1	-0.7	-3.0	-0.3	-1.4	0.2
Average weekly red wine intake	0.7	1.0	3.3	-1.8	0.1	0.0	1.2	-0.4
Handedness (chirality/laterality): Left-handed	1.0	1.2	5.1	-0.5	-0.8	-0.1	-0.1	2.2
Mood swings	0.4	0.8	2.0	1.4	1.1	-0.5	0.1	-0.5
Loneliness, isolation	1.9	2.6	7.3	1.1	2.7	-1.1	1.2	1.3
Long-standing illness, disability or infirmity	0.7	1.1	2.3	1.3	1.5	-0.8	0.7	-0.3
Ever had bowel cancer screening	0.4	0.5	0.7	0.2	0.6	-0.7	-0.8	-0.8
Diabetes diagnosed by doctor	1.0	1.6	4.9	0.1	2.2	-1.7	-0.1	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	3.1	0.2	-0.6	1.8	-0.1	0.9
Friendships satisfaction	0.7	0.9	2.3	-0.2	1.5	0.6	-0.1	1.3
Qualifications: nursing, teaching	0.4	0.5	1.2	0.7	-0.8	-0.6	1.1	-0.3
Commuting to job workplace: Walk	0.5	0.6	0.9	0.5	0.9	0.7	-0.9	-0.6
Eye problems/disorders: Cataract	0.6	0.7	1.3	-0.8	-1.0	0.3	-0.9	1.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.5	0.4	0.4	-0.7	0.3	0.1
Medication for cholesterol	0.1	0.2	0.5	-0.2	0.7	0.6	-0.3	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.7	0.4	-0.9	-0.4	0.3	-0.2
Back pain experienced in last month	0.5	0.8	2.0	0.9	-0.7	0.8	1.4	0.2
Mineral and other dietary supplements	0.4	0.6	1.6	0.3	-0.6	0.4	-0.8	1.3
Breast cancer (self-reported)	0.5	0.6	1.4	0.7	0.3	1.2	0.2	0.8
Asthma (self-reported)	0.8	1.5	4.4	2.1	0.0	-1.3	-0.8	0.9
Osteoporosis (self-reported)	1.2	1.4	4.9	0.4	2.2	0.1	1.3	-0.6
Osteoarthritis (self-reported)	0.4	0.5	0.8	-0.9	-0.4	-0.0	-0.8	0.9
Medication: Aspirin	0.9	1.2	3.6	-0.1	-1.9	-0.0	-1.4	-0.6
Medication: Gliclazide	0.9	1.0	2.1	-1.1	0.8	-1.5	-0.7	0.7
Illnesses of father: None of the above (group 1)	0.6	0.7	2.7	0.7	0.6	-0.3	0.2	-1.6
Smoking status: Current	1.1	1.8	3.3	-0.9	-1.8	0.9	-1.0	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	4.0	0.8	1.5	0.1	-0.5	-2.0
Whole body water mass	1.2	6.7	16.6	4.1	3.3	2.4	0.7	-0.5
Leg predicted mass (right)	0.6	3.0	6.9	2.6	2.5	1.2	-0.0	-0.3
Arm fat mass (left)	0.2	0.7	2.1	0.6	-1.4	0.7	-0.8	-0.2
Number of self-reported non-cancer illnesses	0.5	0.9	4.0	-0.3	0.6	-2.0	0.6	0.2
Average weekly champagne plus white wine intake	0.5	0.7	1.8	1.3	1.1	0.5	-0.6	-0.1
Miserableness	1.5	2.6	4.6	1.9	2.1	-1.2	1.8	-0.2
Guilty feelings	0.9	1.4	3.2	1.2	1.8	-1.3	0.8	0.5
Wears glasses or contact lenses	1.9	2.2	4.5	2.1	0.7	0.6	2.1	-1.1
Ever taken oral contraceptive pill	0.3	0.3	0.8	0.6	0.3	-0.9	0.0	-0.6
Hearing aid user	0.9	1.0	2.8	1.7	0.4	1.4	0.2	0.3
Mother’s age at death	0.7	0.8	2.2	-1.5	0.1	-1.1	-0.6	-0.6
Financial situation satisfaction	1.1	1.4	3.1	-1.7	0.6	-1.3	-0.1	1.3
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.3	0.5	1.1	-0.3	-0.5	0.3
Commuting to job workplace: Public transport	1.6	1.9	5.8	-1.1	-0.9	-2.4	-1.4	-0.2
Eye problems/disorders: Glaucoma	0.5	0.6	2.1	0.1	-0.4	-0.6	0.4	-1.5
Medication: Blood pressure	0.7	1.4	2.4	-0.1	-1.6	-0.2	1.6	-1.4
Pain type(s) experienced in last month: Hip pain	1.0	1.3	4.5	0.4	1.2	-0.5	-0.3	2.1
Supplements: Fish oil (including cod liver oil)	0.8	1.1	3.9	-2.0	-0.4	-0.3	-0.8	0.7
High cholesterol (Self-reported)	0.7	1.2	2.8	-1.5	-0.8	-0.1	-0.7	1.7
Medication: Bendroflumethiazide	0.4	0.6	1.6	0.0	0.1	-1.1	0.1	-1.3
Medication: Paracetamol	0.6	0.9	1.8	0.5	-1.0	0.1	1.4	-1.2
Medication: Lisinopril	0.8	1.1	2.3	1.4	0.2	0.7	1.5	-0.8
Medication: Atorvastatin	0.3	0.4	1.0	-0.8	-0.0	-0.0	0.5	1.0
Illnesses of father: High blood pressure	0.8	1.0	3.3	-0.8	-0.7	-0.7	-0.6	1.8
Alcohol drinker status: Never	0.5	0.6	2.5	0.5	0.1	-0.4	0.2	1.6
Ever smoked	1.1	2.0	4.0	1.1	-0.7	2.0	-1.5	1.5
Basal metabolic rate	1.0	5.5	14.4	3.8	2.8	2.2	0.5	-0.6
Leg fat percentage (left)	0.3	0.9	3.3	0.4	-1.8	0.1	-1.0	0.0
Arm fat-free mass (left)	1.1	5.7	15.0	3.9	2.8	2.3	0.2	-0.3
Number of operations (self-reported)	2.0	3.0	5.0	1.8	1.5	-1.7	2.2	-1.3
Average weekly beer plus cider intake	0.2	0.3	0.8	0.1	0.2	-0.9	0.7	0.6
Irritability	0.3	0.4	1.8	0.3	0.6	-1.3	-0.1	0.0
Risk taking	0.7	1.0	1.8	1.4	-1.2	1.2	0.3	-0.2
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.7	1.3	0.4	0.8	0.0	0.6
Fractured/broken bones in last 5 years	0.3	0.4	1.2	0.2	-0.7	0.6	-0.1	1.1
Age started oral contraceptive pill	0.7	0.9	3.2	-1.8	-0.7	-0.4	0.2	-0.8
Diastolic blood pressure, automated reading	0.4	1.3	2.9	-0.6	-1.4	0.3	-1.0	1.7
Ever depressed for a whole week	2.9	3.5	6.3	2.1	2.0	2.5	0.7	-1.4
Unable to work because of sickness or disability	0.8	1.1	3.3	0.1	1.0	0.5	-1.0	1.8
Commuting to job workplace: Cycle	1.4	1.7	6.2	1.1	0.2	-0.4	0.8	-2.5
Myopia	0.7	1.0	1.7	0.9	1.3	1.1	0.5	1.0
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.9	-0.3	0.6	0.5	-0.9	-0.0
Cholesterol lowering medication	0.9	1.3	3.2	-1.5	-0.9	-0.6	0.1	1.8
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	2.9	-0.3	0.2	0.3	-1.7	0.9
Pain experienced in last month	0.3	0.5	1.3	-0.3	1.1	0.6	-0.4	-0.6
Supplements: Calcium	0.4	0.4	1.2	0.6	1.1	-0.4	0.6	-0.4
Basal cell carcinoma (self-reported)	0.3	0.4	0.9	0.4	-0.4	0.7	0.9	-0.6
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.9	0.9	-0.3	-0.1	-1.0	0.6
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.7	1.6	-0.8	0.5	0.6	0.1
Heart disease (siblings)	2.9	3.6	12.0	1.3	0.5	-1.0	1.7	-3.5
Alcohol drinker status: Previous	0.7	0.8	2.2	0.7	1.5	-0.2	1.0	0.3
Pack years of smoking	0.2	0.2	0.8	-0.1	-0.9	0.0	0.3	-0.5
Impedance of whole body	0.1	0.4	0.9	-0.2	0.4	1.0	0.4	-0.8
Leg fat mass (left)	0.3	1.1	2.7	1.6	-0.9	1.1	-0.9	0.2
Arm predicted mass (left)	1.3	6.5	17.0	4.1	3.1	2.2	0.7	-0.7