Best TWAS P=2.42e-20 · Best GWAS P=4.56e-24 conditioned to 1.86e-05
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RNF181 | 0.07 | 0.02 | bslmm | 476 | 0.03 | 3.4e-04 | 9.1 | 8.0 | 1.2e-15 | 0.59 | 0.02 | 0.92 | FALSE |
2 | GTEx | Adipose Subcutaneous | GGCX | 0.16 | 0.09 | lasso | 5 | 0.08 | 3.1e-07 | 8.0 | 7.8 | 6.8e-15 | 0.71 | 0.99 | 0.00 | FALSE |
3 | GTEx | Adipose Visceral Omentum | GGCX | 0.13 | 0.03 | lasso | 7 | 0.03 | 1.1e-02 | 7.9 | 7.1 | 1.1e-12 | 0.68 | 0.32 | 0.27 | FALSE |
4 | GTEx | Artery Aorta | GGCX | 0.23 | 0.22 | lasso | 6 | 0.23 | 5.5e-13 | 7.9 | 8.8 | 1.8e-18 | 0.74 | 0.97 | 0.03 | FALSE |
5 | GTEx | Artery Tibial | GGCX | 0.29 | 0.22 | enet | 14 | 0.24 | 6.3e-19 | 7.8 | 8.3 | 8.8e-17 | 0.69 | 1.00 | 0.00 | FALSE |
6 | GTEx | Brain Cerebellar Hemisphere | GGCX | 0.46 | 0.41 | enet | 16 | 0.48 | 5.3e-14 | 6.3 | 8.1 | 4.6e-16 | 0.72 | 0.98 | 0.02 | FALSE |
7 | GTEx | Brain Cerebellum | GGCX | 0.54 | 0.30 | lasso | 10 | 0.34 | 6.0e-11 | 8.0 | 8.3 | 7.1e-17 | 0.75 | 0.96 | 0.04 | FALSE |
8 | GTEx | Brain Cortex | GGCX | 0.38 | 0.17 | enet | 30 | 0.02 | 1.1e-01 | 6.3 | 7.5 | 9.5e-14 | 0.60 | 0.48 | 0.18 | FALSE |
9 | GTEx | Brain Nucleus accumbens basal ganglia | GGCX | 0.28 | 0.09 | enet | 7 | 0.02 | 7.6e-02 | 6.3 | 7.9 | 3.0e-15 | 0.67 | 0.10 | 0.25 | FALSE |
10 | GTEx | Breast Mammary Tissue | GGCX | 0.14 | 0.01 | lasso | 3 | 0.01 | 1.0e-01 | 8.0 | 8.0 | 9.3e-16 | 0.69 | 0.13 | 0.11 | FALSE |
11 | GTEx | Breast Mammary Tissue (Male) | GGCX | 0.10 | 0.00 | enet | 4 | 0.00 | 3.3e-01 | 6.1 | 7.4 | 1.3e-13 | 0.69 | 0.06 | 0.09 | FALSE |
12 | GTEx | Cells EBV-transformed lymphocytes | GGCX | 0.36 | 0.31 | enet | 18 | 0.29 | 4.5e-10 | 6.2 | 7.8 | 4.2e-15 | 0.71 | 0.99 | 0.01 | FALSE |
13 | GTEx | Colon Transverse | GGCX | 0.26 | 0.28 | lasso | 3 | 0.28 | 1.4e-13 | 8.0 | 8.3 | 7.5e-17 | 0.73 | 0.98 | 0.02 | FALSE |
14 | GTEx | Esophagus Gastroesophageal Junction | GGCX | 0.24 | 0.16 | lasso | 6 | 0.12 | 4.3e-05 | 8.1 | 8.8 | 1.6e-18 | 0.74 | 0.38 | 0.38 | FALSE |
15 | GTEx | Esophagus Mucosa | GGCX | 0.29 | 0.21 | enet | 30 | 0.27 | 5.8e-18 | 7.8 | 7.6 | 2.8e-14 | 0.62 | 1.00 | 0.00 | FALSE |
16 | GTEx | Esophagus Mucosa | VAMP8 | 0.41 | 0.31 | lasso | 6 | 0.36 | 6.6e-25 | 8.1 | -6.9 | 3.9e-12 | -0.66 | 1.00 | 0.00 | FALSE |
17 | GTEx | Esophagus Mucosa | TMEM150A | 0.10 | 0.05 | enet | 5 | 0.05 | 3.2e-04 | 8.0 | -8.6 | 6.2e-18 | -0.80 | 0.06 | 0.88 | FALSE |
18 | GTEx | Esophagus Muscularis | GGCX | 0.14 | 0.12 | lasso | 9 | 0.12 | 1.1e-07 | 7.9 | 8.2 | 3.6e-16 | 0.75 | 0.65 | 0.35 | FALSE |
19 | GTEx | Esophagus Muscularis | AC015971.2 | 0.09 | 0.03 | lasso | 6 | 0.05 | 9.1e-04 | -5.6 | 5.5 | 4.5e-08 | 0.02 | 0.04 | 0.86 | TRUE |
20 | GTEx | Lung | GGCX | 0.17 | 0.17 | lasso | 2 | 0.18 | 2.3e-13 | 8.1 | 8.1 | 6.9e-16 | 0.72 | 1.00 | 0.00 | FALSE |
21 | GTEx | Muscle Skeletal | GGCX | 0.10 | 0.04 | enet | 11 | 0.02 | 2.7e-03 | 7.9 | 9.2 | 2.4e-20 | 0.78 | 0.09 | 0.90 | TRUE |
22 | GTEx | Muscle Skeletal | USP39 | 0.18 | 0.10 | lasso | 3 | 0.10 | 1.1e-09 | 7.6 | -6.9 | 5.2e-12 | -0.63 | 0.93 | 0.07 | FALSE |
23 | GTEx | Muscle Skeletal | VAMP5 | 0.09 | 0.05 | enet | 23 | 0.05 | 5.7e-06 | 9.1 | -6.7 | 1.7e-11 | -0.66 | 0.05 | 0.95 | FALSE |
24 | GTEx | Nerve Tibial | GGCX | 0.38 | 0.30 | lasso | 7 | 0.33 | 6.5e-24 | 7.8 | 8.4 | 5.5e-17 | 0.72 | 1.00 | 0.00 | FALSE |
25 | GTEx | Pancreas | VAMP5 | 0.29 | 0.09 | enet | 4 | 0.05 | 3.2e-03 | 6.5 | -7.7 | 1.3e-14 | -0.66 | 0.02 | 0.76 | FALSE |
26 | GTEx | Prostate | GGCX | 0.31 | 0.16 | lasso | 4 | 0.20 | 1.0e-05 | 6.3 | 5.7 | 9.3e-09 | 0.60 | 0.07 | 0.67 | FALSE |
27 | GTEx | Skin Not Sun Exposed Suprapubic | GGCX | 0.13 | 0.04 | enet | 11 | 0.06 | 3.9e-04 | 8.0 | 9.1 | 6.3e-20 | 0.64 | 0.34 | 0.15 | FALSE |
28 | GTEx | Skin Sun Exposed Lower leg | GGCX | 0.15 | 0.11 | lasso | 3 | 0.18 | 7.9e-15 | 8.0 | 8.4 | 4.1e-17 | 0.69 | 1.00 | 0.00 | FALSE |
29 | GTEx | Skin Sun Exposed Lower leg | VAMP8 | 0.14 | 0.13 | enet | 19 | 0.13 | 5.4e-11 | 4.0 | -5.7 | 1.1e-08 | -0.49 | 1.00 | 0.00 | FALSE |
30 | GTEx | Testis | GGCX | 0.38 | 0.36 | enet | 25 | 0.40 | 8.6e-19 | 8.1 | 9.0 | 3.1e-19 | 0.72 | 0.83 | 0.17 | FALSE |
31 | GTEx | Thyroid | ELMOD3 | 0.10 | 0.01 | enet | 10 | 0.02 | 7.7e-03 | -4.7 | 6.2 | 7.5e-10 | 0.28 | 0.22 | 0.30 | FALSE |
32 | GTEx | Thyroid | GGCX | 0.30 | 0.17 | enet | 10 | 0.23 | 1.4e-17 | 8.0 | 8.9 | 6.9e-19 | 0.74 | 0.99 | 0.01 | FALSE |
33 | GTEx | Whole Blood | CAPG | 0.12 | 0.03 | lasso | 3 | 0.04 | 5.3e-05 | 4.8 | -5.8 | 7.1e-09 | -0.02 | 0.35 | 0.04 | FALSE |
34 | GTEx | Whole Blood | GGCX | 0.15 | 0.14 | lasso | 4 | 0.15 | 1.7e-13 | 8.0 | 8.4 | 3.5e-17 | 0.73 | 1.00 | 0.00 | FALSE |
35 | METSIM | Adipose | GGCX | 0.07 | 0.09 | lasso | 8 | 0.09 | 9.6e-14 | 6.1 | 7.2 | 5.7e-13 | 0.70 | 0.98 | 0.02 | FALSE |
36 | METSIM | Adipose | VAMP5 | 0.05 | 0.03 | lasso | 8 | 0.01 | 2.9e-03 | 6.9 | -7.8 | 5.7e-15 | -0.71 | 0.29 | 0.70 | FALSE |
37 | NTR | Blood | CAPG | 0.11 | 0.05 | bslmm | 463 | 0.10 | 3.7e-29 | -4.7 | -5.5 | 2.9e-08 | -0.14 | 1.00 | 0.00 | FALSE |
38 | NTR | Blood | VAMP8 | 0.05 | 0.04 | lasso | 8 | 0.04 | 2.0e-12 | 7.4 | -7.6 | 2.5e-14 | -0.74 | 1.00 | 0.00 | FALSE |
39 | ROSMAP | Brain Pre-frontal Cortex | GGCX | 0.12 | 0.10 | lasso | 4 | 0.12 | 5.4e-15 | 6.8 | 6.3 | 3.5e-10 | 0.60 | 1.00 | 0.00 | FALSE |
40 | ROSMAP | Brain Pre-frontal Cortex | USP39 | 0.34 | 0.31 | enet | 9 | 0.33 | 4.0e-43 | 6.7 | -5.2 | 1.5e-07 | -0.50 | 1.00 | 0.00 | FALSE |
41 | ROSMAP | Brain Pre-frontal Cortex | VAMP5 | 0.09 | 0.01 | enet | 15 | 0.02 | 6.2e-04 | 1.3 | -6.5 | 7.4e-11 | -0.35 | 0.12 | 0.40 | FALSE |
42 | YFS | Blood | CAPG | 0.40 | 0.20 | enet | 65 | 0.37 | 1.2e-128 | -4.7 | -5.3 | 1.1e-07 | -0.02 | 1.00 | 0.00 | TRUE |
43 | YFS | Blood | VAMP8 | 0.15 | 0.15 | enet | 37 | 0.18 | 2.2e-55 | 7.8 | -7.7 | 1.7e-14 | -0.75 | 1.00 | 0.00 | FALSE |
44 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | USP39 | 0.04 | 0.00 | blup | 68 | 0.01 | 1.8e-02 | 7.0 | -8.0 | 8.8e-16 | -0.78 | 0.01 | 0.78 | FALSE |
45 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SFTPB | 0.03 | 0.02 | blup | 44 | 0.02 | 3.8e-05 | 7.6 | -5.8 | 5.7e-09 | -0.55 | 0.29 | 0.55 | FALSE |
46 | The Cancer Genome Atlas | Breast Invasive Carcinoma | USP39 | 0.02 | 0.00 | blup | 67 | 0.01 | 1.7e-03 | 10.1 | -8.1 | 7.4e-16 | -0.78 | 0.01 | 0.92 | FALSE |
47 | The Cancer Genome Atlas | Colon Adenocarcinoma | C2orf68 | 0.06 | 0.06 | lasso | 2 | 0.05 | 1.1e-03 | 9.1 | -9.2 | 5.9e-20 | -0.88 | 0.02 | 0.68 | FALSE |
48 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GGCX | 0.05 | 0.05 | lasso | 1 | 0.04 | 1.2e-05 | 8.1 | 8.1 | 5.1e-16 | 0.72 | 0.77 | 0.06 | FALSE |
49 | The Cancer Genome Atlas | Brain Lower Grade Glioma | USP39 | 0.07 | 0.05 | lasso | 5 | 0.05 | 5.2e-06 | 7.0 | -5.3 | 1.3e-07 | -0.51 | 0.90 | 0.04 | FALSE |
50 | The Cancer Genome Atlas | Brain Lower Grade Glioma | VAMP5 | 0.06 | 0.04 | lasso | 2 | 0.04 | 3.2e-05 | 6.2 | -5.8 | 6.2e-09 | -0.63 | 0.15 | 0.71 | FALSE |
51 | The Cancer Genome Atlas | Brain Lower Grade Glioma | VPS24 | 0.05 | 0.02 | enet | 12 | 0.03 | 2.9e-04 | -5.5 | 5.4 | 7.9e-08 | 0.04 | 0.02 | 0.91 | FALSE |
52 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | RNF103 | 0.06 | 0.02 | blup | 42 | 0.02 | 2.4e-02 | 4.9 | -5.4 | 8.0e-08 | -0.03 | 0.01 | 0.61 | FALSE |
53 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | USP39 | 0.10 | 0.07 | blup | 62 | 0.04 | 7.1e-03 | 6.9 | -7.3 | 2.4e-13 | -0.60 | 0.04 | 0.31 | FALSE |
54 | The Cancer Genome Atlas | Lung Adenocarcinoma | RNF181 | 0.03 | 0.00 | blup | 39 | 0.01 | 1.5e-02 | 7.6 | -6.7 | 2.8e-11 | -0.67 | 0.01 | 0.52 | FALSE |
55 | The Cancer Genome Atlas | Lung Adenocarcinoma | USP39 | 0.04 | 0.02 | blup | 67 | 0.03 | 2.0e-04 | 8.1 | -8.4 | 6.1e-17 | -0.76 | 0.07 | 0.83 | FALSE |
56 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | VAMP5 | 0.07 | 0.04 | blup | 44 | 0.05 | 2.1e-06 | 6.5 | -5.9 | 3.1e-09 | -0.49 | 0.33 | 0.40 | FALSE |
57 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RETSAT | 0.12 | 0.01 | blup | 56 | 0.03 | 4.9e-03 | -4.6 | 5.3 | 1.2e-07 | 0.05 | 0.01 | 0.25 | FALSE |
58 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | VAMP8 | 0.06 | 0.01 | enet | 15 | 0.02 | 2.1e-02 | 6.3 | 6.0 | 1.7e-09 | 0.45 | 0.05 | 0.09 | FALSE |
59 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GGCX | 0.04 | 0.02 | blup | 44 | 0.02 | 2.7e-03 | 6.4 | 8.4 | 6.4e-17 | 0.72 | 0.18 | 0.53 | FALSE |
60 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TMEM150A | 0.06 | 0.05 | lasso | 3 | 0.04 | 3.9e-05 | 7.6 | -7.6 | 2.6e-14 | -0.70 | 0.47 | 0.35 | FALSE |
61 | The Cancer Genome Atlas | Prostate Adenocarcinoma | USP39 | 0.09 | 0.12 | lasso | 2 | 0.11 | 1.5e-11 | 6.7 | -6.7 | 2.5e-11 | -0.64 | 1.00 | 0.00 | FALSE |
62 | The Cancer Genome Atlas | Soft Tissue Sarcoma | GGCX | 0.04 | 0.03 | lasso | 2 | 0.03 | 1.1e-02 | 7.8 | 7.8 | 6.9e-15 | 0.70 | 0.06 | 0.05 | FALSE |
63 | The Cancer Genome Atlas | Thyroid Carcinoma | GGCX | 0.03 | 0.03 | enet | 5 | 0.02 | 8.7e-03 | 7.2 | 7.9 | 3.9e-15 | 0.82 | 0.05 | 0.56 | FALSE |
64 | The Cancer Genome Atlas | Thyroid Carcinoma | VAMP8 | 0.04 | 0.05 | lasso | 3 | 0.05 | 1.2e-05 | 7.8 | -8.5 | 1.3e-17 | -0.77 | 0.36 | 0.47 | FALSE |