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chr12:119,870,094-122,037,099

Best TWAS P=7.7e-10 · Best GWAS P=3.12e-09 conditioned to 0.741

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
21	NTR	Blood	COQ5	0.02	0.01	blup	402	0.01	1.9e-03	5.2	6.2	7.7e-10	0.36	0.14	0.83	TRUE
8	GTEx	Esophagus Gastroesophageal Junction	UNC119B	0.16	0.01	lasso	6	0.00	2.3e-01	4.8	6.0	2.6e-09	0.43	0.06	0.54	TRUE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	C12orf43	0.06	0.00	blup	57	0.03	4.1e-04	-2.5	-5.4	8.3e-08	-0.38	0.01	0.84	TRUE
5	GTEx	Artery Tibial	COQ5	0.36	0.31	enet	29	0.33	8.3e-27	5.2	5.6	2.2e-08	0.20	0.13	0.86	FALSE
20	GTEx	Uterus	COQ5	0.39	0.26	enet	18	0.25	8.6e-06	5.2	5.5	2.9e-08	0.21	0.11	0.69	FALSE
13	GTEx	Lung	COQ5	0.25	0.22	enet	23	0.20	1.2e-15	5.2	5.5	4.7e-08	0.23	0.13	0.86	FALSE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	COQ5	0.06	0.01	lasso	9	0.02	1.3e-03	5.3	5.4	6.8e-08	0.16	0.01	0.97	FALSE
19	GTEx	Testis	COQ5	0.24	0.17	enet	20	0.15	2.9e-07	5.2	5.4	7.5e-08	0.23	0.14	0.86	FALSE
28	The Cancer Genome Atlas	Lung Adenocarcinoma	COQ5	0.05	0.04	lasso	3	0.04	2.5e-05	5.2	5.3	9.3e-08	0.19	0.01	0.98	FALSE
18	GTEx	Skin Sun Exposed Lower leg	TRIAP1	0.07	0.07	lasso	4	0.07	2.4e-06	5.2	-5.3	9.4e-08	-0.17	0.13	0.85	FALSE
27	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TRIAP1	0.03	0.01	lasso	3	0.01	2.2e-02	5.2	-5.3	1.2e-07	-0.19	0.00	0.88	FALSE
2	GTEx	Adipose Visceral Omentum	COQ5	0.16	0.16	enet	15	0.17	4.3e-09	5.2	5.3	1.4e-07	0.19	0.14	0.86	FALSE
4	GTEx	Artery Tibial	GCN1L1	0.13	0.06	enet	24	0.05	7.0e-05	3.1	5.3	1.4e-07	0.07	0.92	0.01	FALSE
17	GTEx	Skin Sun Exposed Lower leg	COQ5	0.28	0.25	enet	36	0.26	3.8e-21	5.2	5.3	1.4e-07	0.19	0.14	0.86	FALSE
29	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	COQ5	0.05	0.04	lasso	4	0.02	1.6e-02	5.2	5.2	1.6e-07	0.21	0.01	0.93	FALSE
24	The Cancer Genome Atlas	Colon Adenocarcinoma	COQ5	0.11	0.13	lasso	1	0.12	3.0e-07	5.2	5.2	1.7e-07	0.20	0.01	0.99	FALSE
32	The Cancer Genome Atlas	Soft Tissue Sarcoma	COQ5	0.09	0.08	lasso	9	0.07	8.9e-05	5.2	5.2	1.7e-07	0.20	0.01	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DYNLL1	0.06	0.01	blup	413	0.05	2.1e-06	-2.2	5.2	1.9e-07	0.16	0.20	0.46	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	COQ5	0.10	0.16	lasso	4	0.16	5.6e-15	5.2	5.2	1.9e-07	0.20	0.01	0.99	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	TRIAP1	0.10	0.09	enet	14	0.09	1.8e-05	5.2	-5.2	2.0e-07	-0.20	0.13	0.86	FALSE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRIAP1	0.02	0.03	lasso	3	0.02	9.2e-06	5.2	-5.2	2.0e-07	-0.20	0.00	0.99	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	COQ5	0.12	0.21	lasso	4	0.20	1.4e-22	5.2	5.2	2.0e-07	0.20	0.01	0.98	FALSE
3	GTEx	Adrenal Gland	COQ5	0.20	0.17	lasso	5	0.18	5.8e-07	5.2	5.2	2.1e-07	0.20	0.13	0.85	FALSE
9	GTEx	Esophagus Mucosa	TRIAP1	0.08	0.08	lasso	1	0.04	8.3e-04	5.2	-5.2	2.1e-07	-0.20	0.13	0.85	FALSE
31	The Cancer Genome Atlas	Prostate Adenocarcinoma	COQ5	0.10	0.14	lasso	5	0.15	4.5e-15	5.2	5.2	2.2e-07	0.20	0.01	0.99	FALSE
12	GTEx	Heart Left Ventricle	COQ5	0.40	0.47	lasso	16	0.47	1.0e-27	5.3	5.2	2.3e-07	0.21	0.13	0.87	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	COQ5	0.05	0.07	enet	9	0.07	4.9e-15	5.2	5.2	2.3e-07	0.19	0.01	0.99	FALSE
6	GTEx	Brain Cerebellum	COQ5	0.29	0.25	lasso	2	0.25	5.4e-08	5.2	5.2	2.4e-07	0.20	0.13	0.86	FALSE
10	GTEx	Esophagus Muscularis	COQ5	0.36	0.34	lasso	9	0.34	2.2e-21	5.1	5.2	2.4e-07	0.22	0.14	0.86	FALSE
7	GTEx	Breast Mammary Tissue	COQ5	0.16	0.19	lasso	14	0.18	1.1e-09	5.2	5.2	2.6e-07	0.20	0.13	0.86	FALSE
11	GTEx	Heart Atrial Appendage	SPPL3	0.17	0.04	enet	20	0.03	1.7e-02	3.2	-5.1	2.7e-07	-0.20	0.14	0.06	FALSE
14	GTEx	Muscle Skeletal	TRIAP1	0.07	0.07	lasso	3	0.06	1.0e-06	5.3	-5.1	2.8e-07	-0.19	0.13	0.87	FALSE
15	GTEx	Nerve Tibial	COQ5	0.23	0.21	lasso	6	0.22	7.8e-16	5.2	5.1	3.0e-07	0.18	0.13	0.87	FALSE