Hub : Genes

DYNLL1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0570 0.0210 0.00027 0.014 0.047 0.032 0.046 0.019 6.5e-03 2.1e-06 8.7e-05 2.4e-06 1.7e-03
2 GTEx Testis 0.1990 0.0740 0.00310 0.110 NA 0.100 NA 0.111 1.4e-05 NA 3.3e-05 NA 1.2e-05
3 METSIM Adipose 0.0308 0.0167 0.01500 0.033 0.006 0.016 0.015 0.025 9.9e-06 3.6e-02 1.7e-03 2.4e-03 9.4e-05
4 YFS Blood 0.0169 0.0071 0.00110 0.004 0.009 0.011 0.009 0.012 1.0e-02 5.5e-04 1.1e-04 4.0e-04 7.9e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 2.2 3.5 5.8 -0.3 -2.2 -2.4 1.8
Bipolar Disorder or Schizophrenia 0.7 1.8 6.5 2.6 0.5 -0.5 -0.2
Depressed Affect (Nagel 2018) 1.1 2.3 4.5 2.0 0.8 2.1 0.1
Depression (Nagel 2018) 0.8 1.3 3.3 1.8 0.6 1.0 0.6
Intelligence (Savage-Jansen 2018) 4.1 12.6 27.9 -5.3 -4.5 -0.9 1.1
Neuroticism (Nagel 2018) 2.0 4.8 8.8 2.6 1.9 3.0 0.0
Schizophrenia (2018) 2.7 5.7 12.7 3.6 2.4 1.3 -1.7
Schizophrenia vs Biploar Disorder 4.3 5.7 8.3 2.9 2.4 2.4 -1.7
Worry (Nagel 2018) 1.3 2.7 6.6 1.2 1.0 2.6 1.2
Alzheimer’s Disease (in mother) 0.7 0.9 2.8 -0.4 -0.5 -1.7 -0.4
Alzheimer’s Disease (in father) 0.4 0.4 1.2 0.4 0.4 1.1 -0.4
Alzheimer’s Disease (including proxy) 0.6 0.9 2.5 -0.1 0.7 -0.7 -1.6
Crohns Disease (2017) 0.4 1.0 2.8 0.2 -1.7 -1.0 0.3
Irritable Bowel Disease (IBD) 0.5 1.2 2.3 0.4 -1.5 -1.3 0.8
Ulcerative Colitis (UC) 0.5 0.9 1.5 0.3 -1.0 -1.2 1.0
Major Depression (MDD) 0.1 0.2 0.6 0.1 -0.2 -0.1 -0.8
Reaction Time 0.7 1.4 4.3 2.1 0.2 -1.1 -0.2
Verbal and Numeric Reasoning (VNR) 1.9 4.6 10.4 -3.2 -2.8 -0.1 0.3
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 4.3 5.7 13.8 3.7 2.8 0.3 -1.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.7 1.1 3.2 -1.8 -0.2 -1.0 0.2
Bipolar Disorder (2011) 1.9 1.8 3.6 -1.1 -1.9 -1.0 1.1
Body Mass Index (BMI) (2010) 3.0 4.1 7.8 -0.0 1.7 2.4 -2.8
Coronary Artery Disease (CAD) 2.5 3.0 7.0 2.7 1.8 1.3 -0.4
Crohns Disease (2012) 0.3 0.5 1.7 0.1 -1.3 -0.0 0.6
Mean Putamen Volume 1.1 1.3 2.4 -1.5 -1.2 0.8 0.9
Fasting Glucose 0.9 1.0 1.4 -0.7 -1.0 1.1 1.2
HbA1C 0.4 0.4 0.9 0.7 -0.6 -0.9 -0.0
HDL Cholesterol 1.3 2.2 6.2 0.1 -1.5 -2.5 0.8
LDL Cholesterol 1.8 2.8 6.9 2.6 0.3 -1.2 1.7
Lupus 0.8 1.2 2.7 -1.2 -1.6 -0.2 0.8
Neuroticism (2016) 2.8 4.0 9.5 3.1 2.0 1.5 0.2
Primary Biliary Cirrhosis 0.6 0.9 1.8 1.0 0.3 0.9 -1.3
Rheumatoid Arthritis 1.0 1.4 4.2 0.7 0.6 2.1 0.6
Schizophrenia (2014) 2.0 4.5 11.8 3.4 1.9 0.5 -1.5
Triglycerides 1.3 2.1 4.7 2.2 1.7 0.6 -0.4
Type 2 Diabetes (T2D) (2012) 1.5 1.7 5.7 2.4 1.0 -0.6 0.3
Ulcerative Colitis 0.3 0.4 0.8 0.9 -0.0 0.3 0.8
Blood Eosinophil Count 0.4 3.5 7.0 -2.4 0.8 2.6 0.5
Blood Platelet Count 0.6 7.4 27.9 -5.3 -1.0 -0.8 0.1
Blood Red Count 2.5 24.0 57.5 7.6 4.0 -2.2 -4.2
Blood White Count 0.2 1.2 4.2 -2.0 0.4 -0.0 0.6
Heel T-Score 0.2 1.9 5.8 -0.2 0.9 -2.4 0.9
BMI 0.3 1.8 6.0 0.2 1.1 -0.3 -2.4
Height 0.9 16.8 55.3 -1.0 -2.4 2.3 7.4
Waist Hip Ratio (WHR) 1.0 4.7 5.2 1.9 2.3 2.3 -2.2
Systolic Blood Pressure 0.9 4.7 7.9 -2.8 -1.0 -1.5 2.8
Smoking Status 6.8 16.3 27.1 5.2 3.7 1.0 -4.8
Allergy or Eczema 0.8 2.0 2.9 -1.7 1.1 1.3 -1.5
Cardiovascular Disease 0.1 0.5 1.3 0.8 -0.1 -1.2 0.1
Hypothyroidism (self reported) 0.4 1.0 1.9 -1.2 -0.5 0.3 1.4
Respiratory disease 0.5 1.1 2.4 -1.5 0.6 0.5 -1.2
Type 2 Diabetes (T2D) (2018) 0.4 0.8 1.9 1.4 0.9 0.5 -0.4
Lung FEV1/FVC ratio 0.8 4.1 6.1 2.5 2.4 0.1 -2.2
Lung FVC 0.3 1.6 3.5 1.9 -1.7 -0.2 0.4
Neuroticism 1.4 3.4 10.1 1.5 0.9 3.2 0.6
Chronotype (morning person) 2.2 5.1 12.6 -1.6 -0.6 3.5 -2.3
Hair Pigment 0.1 2.9 7.4 -0.5 1.6 1.2 -2.7
Tanning 0.0 0.4 1.1 1.0 0.2 0.3 -0.7
Hand grip strength (left) 0.3 0.7 1.2 0.6 1.1 -1.1 -0.0
Number of treatments/medications taken 0.5 0.8 3.1 1.8 0.4 0.1 0.1
Average weekly spirits intake 0.9 1.1 4.1 -2.0 -0.3 -0.4 -0.5
Sensitivity / hurt feelings 0.7 1.2 2.9 0.3 0.7 1.7 1.1
Frequency of depressed mood in last 2 weeks 0.5 0.7 2.2 1.5 0.4 0.5 -0.2
Hearing difficulty/problems: Yes 0.4 0.6 1.9 -0.3 -0.1 1.4 -0.5
Relative age of first facial hair 1.0 2.1 6.2 0.1 2.5 1.4 -0.3
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.3 0.1 -0.5 0.5 0.0
Ever used hormone-replacement therapy (HRT) 1.2 1.5 4.6 2.1 0.9 0.7 -0.2
Ever had hysterectomy (womb removed) 1.3 1.5 3.2 0.3 1.8 -0.1 -1.6
Systolic blood pressure, automated reading 0.3 0.9 2.4 -1.6 0.3 -0.4 0.9
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.3 0.5 0.5 0.5 -0.4
Angina 1.3 1.6 2.1 1.5 1.4 1.3 -0.9
Medication for hormone replacement therapy 1.2 1.3 3.2 1.8 1.3 -0.2 -0.6
Vitamin and mineral supplements 0.4 0.5 1.2 -1.1 -0.1 0.8 0.3
Supplements: Zinc 0.5 0.5 0.9 0.4 -0.6 -1.0 -0.8
Medication: Co-codamol 1.4 1.6 3.7 1.9 0.8 -1.4 0.4
Medication: Metformin 0.9 1.2 2.6 0.5 1.4 0.4 -1.6
Diabetes (father) 0.6 0.8 2.0 0.8 1.4 0.2 -0.6
Diabetes (mother) 6.1 7.7 12.2 3.4 2.7 0.2 -3.5
Severe depression (siblings) 0.5 0.5 1.2 -0.8 -0.5 -0.0 1.1
Pack years adult smoking proportion 1.7 2.6 3.1 1.7 1.6 1.3 -1.8
Impedance of leg (right) 1.2 5.7 14.4 2.6 0.7 3.8 1.0
Leg fat-free mass (left) 0.4 1.9 4.6 -2.1 -0.9 -1.3 0.6
Trunk fat percentage 1.5 5.8 11.4 3.4 2.6 1.9 -1.2
Hand grip strength (right) 0.2 0.5 1.6 -0.2 0.6 -1.2 -0.2
Townsend deprivation index at recruitment 2.7 3.8 4.3 1.8 2.1 2.0 -1.9
Current tobacco smoking 5.6 9.1 17.9 2.7 2.7 1.9 -4.2
Average weekly fortified wine intake 5.0 5.8 7.5 -1.4 -2.7 -2.7 2.5
Maternal smoking around birth 1.7 2.4 4.7 2.2 2.0 1.0 0.4
Fed-up feelings 1.7 3.1 5.7 2.4 1.6 1.8 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 1.6 1.3 1.0 1.1 -0.1
Relative age voice broke 0.7 1.0 1.7 -1.0 1.3 1.0 -0.7
Taking other prescription medications 0.6 0.9 2.9 1.7 0.8 -0.2 0.1
Age when periods started (menarche) 1.5 3.6 7.2 -2.7 -1.8 0.8 1.7
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.4 0.1 0.6 -0.6 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.6 3.8 -1.8 -0.9 -1.6 2.0
Tinnitus: Yes, but not now, but have in the past 1.9 2.0 4.8 1.2 1.1 0.9 -2.2
Qualifications: CSEs or equivalent 2.7 3.6 8.5 1.3 2.9 0.9 -1.9
Serious illness, injury or assault to yourself 0.0 0.0 0.1 -0.1 0.0 0.1 -0.4
High blood pressure 0.1 0.2 0.5 -0.2 0.7 0.6 -0.2
Hayfever, allergic rhinitis or eczema 1.4 3.0 5.4 -0.9 1.9 1.6 -2.3
Multivitamins +/- minerals 0.4 0.5 1.3 0.7 0.1 -1.1 -0.6
Stomach or abdominal pain in last month 2.2 2.7 6.5 2.5 1.7 -0.2 -1.2
Supplements: Glucosamine 1.2 1.6 3.5 -0.4 -0.2 -1.6 -1.9
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.0 0.3 -0.3 -0.5 1.0
Medication: Atenolol 0.8 1.0 2.5 1.6 0.7 -1.1 -0.2
Medication: Levothyroxine sodium 0.1 0.2 0.9 -0.9 -0.2 -0.1 0.2
Sitting height 0.4 2.9 4.9 -2.2 -1.9 0.5 1.8
Chronic bronchitis/emphysema (father) 0.6 0.7 1.7 1.0 0.4 0.2 1.3
High blood pressure (mother) 0.4 0.5 0.6 -0.8 -0.6 0.8 0.7
Body mass index (BMI) 0.5 2.2 5.4 1.1 1.3 -1.0 -2.3
Impedance of leg (left) 1.3 6.5 14.7 3.1 0.6 3.8 1.2
Leg predicted mass (left) 0.4 2.0 4.6 -2.2 -1.0 -1.4 0.7
Trunk fat mass 0.4 1.6 3.4 1.8 1.3 1.1 -0.4
Waist circumference 0.1 0.5 1.0 0.7 0.7 -0.1 -1.0
Number of incorrect matches in round 2.0 3.3 7.0 2.6 2.2 -0.1 -1.1
Past tobacco smoking 3.9 7.2 11.8 -3.4 -3.2 -0.6 2.6
Alcohol usually taken with meals 6.4 10.3 14.7 -2.9 -3.8 -2.6 3.4
Nervous feelings 0.9 1.6 5.1 -0.2 1.1 2.3 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 0.8 0.9 0.4 0.8 0.6
Hearing difficulty/problems with background noise 0.9 1.4 5.2 0.1 0.5 2.3 -0.5
Hair/balding pattern: Pattern 2 0.8 1.0 3.4 0.3 0.4 1.9 -0.4
Had menopause 0.5 0.6 1.1 0.2 -1.1 0.4 1.0
Had other major operations 0.8 0.9 2.2 1.5 0.4 0.6 -1.0
Forced vital capacity (FVC) 0.8 3.0 6.2 -0.8 -2.5 0.0 2.3
Heel bone mineral density (BMD) T-score, automated (right) 1.4 3.3 5.0 -1.8 -1.2 -1.8 2.2
Ever unenthusiastic/disinterested for a whole week 2.4 2.9 5.1 1.2 1.9 1.3 -2.2
Qualifications: None of the above 7.3 15.7 25.6 5.1 4.9 2.7 -2.4
Financial difficulties in last 2 years 0.2 0.3 0.4 0.6 0.5 -0.7 -0.3
Mouth/teeth dental problems 0.2 0.3 1.1 -0.1 0.1 -1.0 0.5
Heart attack 1.9 2.5 7.8 2.8 0.5 0.4 1.3
Allergy 1.5 3.4 5.7 1.5 -1.9 -1.5 2.4
Pain all over the body in last month 1.5 1.6 5.5 0.0 0.9 2.3 -0.4
Diabetes (self-reported) 1.2 1.8 3.2 0.5 1.8 1.0 -1.7
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.6 -0.4 0.7 -0.2 -0.8
Medication: Ramipril 1.0 1.2 2.0 1.3 1.2 1.4 -0.2
Medication: Simvastatin 0.5 0.7 1.0 1.0 0.9 -0.0 -0.9
Fluid intelligence score 2.2 4.5 11.4 -3.4 -2.4 0.7 0.5
Illnesses of siblings 0.5 0.7 1.4 -1.2 -0.8 -0.9 0.0
Neuroticism score 1.9 3.9 9.8 1.5 1.9 3.1 -0.3
Weight 0.0 0.2 0.3 -0.4 -0.5 -0.5 0.3
Impedance of arm (right) 1.9 9.0 14.6 3.4 3.1 3.8 0.5
Arm fat percentage (right) 1.4 5.6 8.9 2.5 3.0 1.0 -2.5
Trunk fat-free mass 1.5 8.5 15.8 -4.0 -3.2 -1.9 2.0
Hip circumference 0.2 1.0 1.4 -0.5 -1.2 -1.1 1.1
Time employed in main current job 0.5 0.6 2.2 -1.5 0.1 -0.4 -0.3
Alcohol intake versus 10 years previously 2.0 3.0 7.4 2.7 1.6 1.3 -0.5
Father’s age at death 0.8 1.0 2.7 -1.6 -1.1 0.5 0.2
Worrier / anxious feelings 1.6 3.0 4.4 2.1 2.0 1.9 -0.4
Frequency of tiredness / lethargy in last 2 weeks 1.4 2.3 3.6 1.9 1.7 1.6 0.4
Falls in the last year 1.4 1.8 4.0 0.5 1.3 2.0 -1.2
Hair/balding pattern: Pattern 3 1.1 1.6 5.4 -0.5 -0.8 -2.3 0.3
Number of live births 1.4 2.0 3.0 0.9 1.6 1.7 -1.4
Forced expiratory volume in 1-second (FEV1) 0.3 1.2 2.4 0.0 -1.5 -0.2 1.5
Pulse rate 0.3 0.5 1.1 -1.1 0.5 0.3 -0.6
Happiness 0.7 0.8 1.8 -1.2 0.3 1.3 0.1
Noisy workplace 4.4 5.5 11.7 3.4 2.8 0.4 -1.5
Qualifications: A levels/AS levels or equivalent 3.4 7.4 13.0 -3.6 -3.6 -1.4 1.4
Serious illness, injury or assault of a close relative in last 2 years 2.0 2.3 3.3 -1.6 -1.6 -1.8 0.9
Mouth/teeth dental problems: Dentures 0.3 0.5 1.1 -0.1 0.9 0.3 -1.1
Asthma 0.8 1.6 3.3 -1.8 1.4 0.3 -0.9
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.6 3.2 0.8 1.6 -0.1 -1.8
Medication: Cholesterol lowering 0.8 1.3 4.7 2.2 0.7 -0.3 0.0
Depression (self-reported) 0.6 0.8 1.6 1.1 0.2 0.3 -1.2
Medication: Lansoprazole 0.8 0.9 1.8 1.3 0.1 -1.4 0.3
Prospective memory result 1.0 1.2 2.1 0.9 1.5 1.3 0.1
Lung cancer (father) 2.0 2.4 6.3 1.4 -0.5 -0.9 2.5
Illnesses of mother 0.1 0.1 0.3 0.4 0.5 0.3 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.8 2.0 -0.2 -1.4 0.1 1.0
Pulse wave Arterial Stiffness index 0.3 0.3 0.6 -0.8 -0.0 0.6 -0.5
Impedance of arm (left) 1.6 7.4 12.7 3.6 2.4 3.1 1.1
Arm fat mass (right) 0.3 1.4 2.5 1.1 1.4 0.2 -1.6
Trunk predicted mass 1.5 8.4 15.9 -4.0 -3.2 -1.8 1.9
Standing height 1.2 12.3 28.1 -2.9 -3.4 1.2 5.3
Length of working week for main job 0.2 0.2 0.7 -0.8 0.4 -0.0 -0.3
Exposure to tobacco smoke at home 0.2 0.3 0.4 0.6 0.5 0.6 0.2
Breastfed as a baby 1.1 1.3 3.5 -0.7 -1.1 -1.9 -0.3
Tense / ‘highly strung’ 1.3 2.2 4.2 1.1 0.1 2.1 1.8
Seen doctor (GP) for nerves, anxiety, tension or depression 4.9 7.5 14.9 3.9 2.7 2.4 -1.4
Hair/balding pattern: Pattern 4 1.9 4.5 9.2 -0.6 -3.0 -1.6 2.5
Birth weight of first child 0.3 0.6 2.2 0.2 0.0 1.5 0.1
Peak expiratory flow (PEF) 0.1 0.2 0.7 0.8 -0.0 -0.3 -0.1
Pulse wave reflection index 0.4 0.5 1.6 -0.6 -1.2 -0.0 -0.2
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.4 0.5 0.6 0.3 -0.6
Loud music exposure frequency 0.2 0.3 1.0 0.1 0.3 0.1 -1.0
Qualifications: O levels/GCSEs or equivalent 4.0 6.4 9.9 -3.1 -2.9 -1.7 2.1
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 1.1 1.0 -0.6 1.0 0.4
Blood clot in the leg (DVT) 0.7 0.9 1.7 -0.6 -0.9 -1.3 0.9
Medication: Paracetamol 2.2 3.6 6.8 2.6 1.9 0.2 -2.0
Headache pain in last month 2.1 3.6 7.2 1.5 2.2 -0.1 -2.7
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.6 -0.8 -0.1 0.7 -0.7
Glaucoma (self-reported) 0.0 0.0 0.1 0.4 0.0 -0.2 -0.0
Gout (self-reported) 1.6 2.3 3.9 1.3 0.5 1.8 -2.0
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.3 -1.1 -0.4 0.4 0.9
Medication: Amlodipine 0.1 0.1 0.1 0.2 0.2 -0.3 -0.4
Medication: Ventolin 100micrograms inhaler 1.2 1.6 5.3 0.4 2.3 0.3 -0.8
Birth weight 0.4 0.8 1.3 -0.5 -0.7 1.1 -1.1
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.7 0.3 -0.2 0.1 0.8
High blood pressure (siblings) 1.5 2.1 3.1 1.8 1.7 0.8 -1.3
Forced vital capacity (FVC), Best measure 0.7 2.5 5.5 -0.9 -2.3 0.3 1.9
Body fat percentage 1.3 5.3 10.1 3.2 2.5 1.5 -1.6
Leg fat percentage (right) 0.9 3.2 5.7 2.4 1.6 1.2 -1.8
Arm fat-free mass (right) 1.2 5.9 9.6 -2.9 -3.1 -1.6 1.7
Exposure to tobacco smoke outside home 1.0 1.4 1.6 1.1 1.3 1.1 -1.1
Comparative body size at age 10 0.7 1.9 4.6 0.6 -2.1 -1.3 1.1
Number of full brothers 2.4 3.1 3.2 1.8 1.7 1.8 -1.7
Worry too long after embarrassment 3.8 6.5 11.7 1.2 2.9 3.4 -2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.5 1.9 4.5 2.1 0.6 1.7 0.2
Wheeze or whistling in the chest in last year 5.3 9.5 13.4 2.8 3.3 2.4 -3.7
Number of children fathered 0.4 0.4 1.3 1.2 0.3 0.5 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 2.2 -1.2 -0.8 -0.1 1.5
Age at first live birth 5.4 9.7 12.7 -3.6 -3.1 -3.4 2.2
Pulse wave peak to peak time 0.4 0.5 1.1 0.5 -0.4 -0.7 1.0
Health satisfaction 1.4 1.8 2.9 1.2 1.7 1.6 -0.6
Shortness of breath walking on level ground 2.5 3.0 5.4 1.1 2.0 2.3 -1.0
Qualifications: College or University degree 4.1 13.0 20.4 -4.2 -4.5 -3.1 1.9
Eye problems/disorders: None of the above 0.5 0.5 0.8 0.3 -0.8 -0.9 -0.8
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.6 -0.3 -0.4 0.8 0.2
Emphysema/chronic bronchitis 4.8 5.4 7.0 2.6 2.2 2.3 -2.2
Medication for pain relief, constipation, heartburn 5.4 9.2 18.6 -4.3 -3.3 -0.8 2.6
Neck or shoulder pain in last month 4.1 5.8 9.3 2.9 3.1 0.7 -2.2
Medication: Blood pressure 0.2 0.4 0.9 0.4 -0.2 -0.8 0.9
Angina (self-reported) 1.2 1.5 1.9 1.4 1.3 1.2 -1.0
Migraine (self-reported) 0.4 0.5 1.7 -0.4 -0.2 -1.3 -0.4
Medication: Ibuprofen 1.7 2.0 3.4 0.8 1.8 0.9 -1.8
Medication: Allopurinol 1.0 1.3 1.5 1.2 0.9 1.2 -1.2
Medication: Omeprazole 2.7 3.2 4.0 1.8 1.9 2.0 -1.4
Medication: Seretide 50 evohaler 2.7 3.1 5.1 1.7 2.3 0.8 -1.9
Mean time to correctly identify matches 1.2 2.4 7.8 2.8 0.1 -1.2 -0.4
Heart disease (mother) 0.1 0.2 0.6 -0.0 -0.8 -0.2 -0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.9 1.2 1.1 1.0 0.5 -1.1
Whole body fat mass 0.3 1.3 2.4 1.6 1.2 0.7 -0.9
Leg fat mass (right) 0.2 0.8 1.3 1.1 0.8 0.4 -1.1
Arm predicted mass (right) 1.1 5.8 9.4 -3.1 -3.0 -1.7 1.4
Pulse rate, automated reading 0.2 0.5 1.8 -0.2 0.2 -0.4 -1.3
Alcohol intake frequency. 0.2 0.6 1.7 0.4 -0.0 -0.7 1.3
Comparative height size at age 10 1.0 5.3 16.4 0.3 -2.2 0.2 4.0
Number of full sisters 0.0 0.0 0.1 -0.1 -0.2 0.1 -0.3
Suffer from ‘nerves’ 0.4 0.7 2.1 0.7 0.2 1.5 0.2
Overall health rating 3.7 7.9 11.0 2.8 3.3 3.3 -1.3
Chest pain or discomfort 2.3 3.4 5.4 2.3 1.6 2.0 -1.3
Had major operations 0.1 0.2 0.3 0.4 0.1 0.5 -0.5
Age at last live birth 1.7 2.5 5.0 -1.3 -1.6 -2.2 0.7
Family relationship satisfaction 0.4 0.5 1.2 -1.1 -0.3 -0.6 0.7
Leg pain on walking 1.1 1.4 3.7 0.1 1.3 1.9 -0.1
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 2.1 0.8 1.5 1.3 -0.8
Commuting to job workplace: Car/motor vehicle 1.1 1.2 3.9 2.0 0.6 0.6 -0.6
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 1.7 1.3 0.4 0.5 -0.9
Medication: Aspirin 1.7 2.3 8.0 2.8 0.6 -0.6 0.6
Supplements: Vitamin C 0.4 0.5 0.7 -0.5 -0.8 -0.6 0.8
Knee pain experienced in last month 0.9 1.4 2.1 1.3 1.5 0.9 -1.1
Hypertension (Self-reported) 0.0 0.1 0.2 -0.4 0.2 -0.3 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 3.7 0.9 1.9 0.2 -0.8
Illnesses of father: Heart disease 0.4 0.5 2.1 1.5 -0.1 -0.2 0.1
Illnesses of siblings: Diabetes 0.6 0.7 2.2 1.5 0.6 0.3 0.3
Smoking status: Previous 2.7 4.0 7.1 2.5 2.7 0.4 -1.7
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.8 3.5 -1.8 -0.5 -0.1 1.9
Whole body fat-free mass 0.9 5.1 10.5 -3.2 -2.3 -1.6 1.4
Leg fat-free mass (right) 0.4 2.1 4.2 -2.1 -1.1 -1.6 0.8
Arm fat percentage (left) 1.1 4.5 7.0 2.6 2.5 0.4 -2.1
Average weekly red wine intake 5.0 7.4 12.0 -1.8 -3.5 -2.8 2.5
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.4 0.3 0.6 -0.2 0.4
Mood swings 1.0 1.8 3.1 1.8 1.3 1.4 -0.6
Loneliness, isolation 0.9 1.2 3.1 1.8 1.2 0.6 -0.2
Long-standing illness, disability or infirmity 1.5 2.3 3.8 1.8 1.4 -0.3 -2.0
Ever had bowel cancer screening 1.0 1.2 2.0 1.4 1.3 0.5 -1.1
Diabetes diagnosed by doctor 1.1 1.8 3.3 0.8 1.7 0.5 -1.8
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.6 0.6 0.4 -0.8 0.2
Friendships satisfaction 3.6 4.4 7.8 -2.8 -2.8 -0.8 1.4
Qualifications: nursing, teaching 3.5 5.5 11.5 -0.8 -3.4 -2.8 1.5
Commuting to job workplace: Walk 0.2 0.2 0.5 -0.4 -0.0 0.7 -0.3
Eye problems/disorders: Cataract 0.2 0.2 0.5 0.2 0.7 0.3 0.6
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 2.9 -0.5 -1.1 -1.7 1.4
Medication for cholesterol 1.3 1.9 3.2 -1.8 -1.5 -1.3 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.5 1.6 1.3 -0.2 0.0 0.7
Back pain experienced in last month 1.3 1.8 4.0 2.0 1.2 1.0 -1.0
Mineral and other dietary supplements 1.1 1.5 5.4 -0.5 -0.3 0.1 2.3
Breast cancer (self-reported) 0.6 0.7 1.4 -1.2 -0.8 -0.2 0.9
Asthma (self-reported) 0.8 1.6 2.6 -1.6 1.6 0.1 -1.1
Osteoporosis (self-reported) 0.9 1.1 1.5 1.2 -0.8 -1.0 1.1
Osteoarthritis (self-reported) 1.1 1.5 4.6 2.1 0.3 1.1 0.1
Medication: Aspirin 1.7 2.2 7.5 2.7 0.8 -0.6 0.4
Medication: Gliclazide 1.3 1.5 3.8 0.4 1.4 0.1 -2.0
Illnesses of father: None of the above (group 1) 0.8 1.0 1.3 -1.1 -1.1 -0.4 1.1
Smoking status: Current 4.9 7.9 14.2 2.9 2.5 1.6 -3.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.3 1.1 -1.5 0.1 0.6
Whole body water mass 1.0 5.9 11.8 -3.4 -2.5 -1.7 1.5
Leg predicted mass (right) 0.4 2.2 4.6 -2.1 -1.1 -1.6 0.8
Arm fat mass (left) 0.3 1.1 1.8 1.1 1.1 0.1 -1.3
Number of self-reported non-cancer illnesses 1.0 1.8 2.8 1.4 1.2 0.9 -1.7
Average weekly champagne plus white wine intake 2.4 3.3 9.1 -3.0 -1.3 -1.6 -0.2
Miserableness 0.8 1.4 2.7 1.6 0.9 1.4 -0.2
Guilty feelings 1.1 1.7 3.5 1.9 0.9 0.9 -1.3
Wears glasses or contact lenses 4.0 4.6 8.5 -1.5 -2.7 -0.5 2.9
Ever taken oral contraceptive pill 0.7 0.8 2.5 -0.3 0.7 0.1 -1.6
Hearing aid user 0.7 0.8 1.8 1.4 0.2 -0.8 -0.9
Mother’s age at death 2.0 2.5 6.2 -2.5 -1.1 -1.7 -0.3
Financial situation satisfaction 1.4 1.8 4.5 0.6 2.1 -0.1 -1.5
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.1 0.5 1.0 -0.2 -0.4
Commuting to job workplace: Public transport 1.4 1.7 4.9 -2.2 -1.1 0.7 0.3
Eye problems/disorders: Glaucoma 0.3 0.3 1.0 1.0 0.1 -0.6 0.2
Medication: Blood pressure 0.0 0.1 0.2 0.2 0.1 0.5 0.3
Pain type(s) experienced in last month: Hip pain 3.7 4.7 11.6 3.4 1.9 1.3 -1.3
Supplements: Fish oil (including cod liver oil) 1.0 1.4 4.6 0.3 0.7 0.4 -2.2
High cholesterol (Self-reported) 1.3 2.4 9.0 3.0 0.3 -0.5 -0.3
Medication: Bendroflumethiazide 0.6 0.8 2.8 -0.1 -0.7 -0.2 1.7
Medication: Paracetamol 1.8 2.8 6.5 2.6 1.5 0.6 -1.4
Medication: Lisinopril 0.7 0.9 1.6 -1.0 -0.9 -0.2 1.3
Medication: Atorvastatin 2.5 3.1 8.8 3.0 1.4 1.2 -0.3
Illnesses of father: High blood pressure 2.0 2.5 4.0 1.7 2.0 0.9 -1.4
Alcohol drinker status: Never 0.1 0.1 0.2 -0.2 -0.4 -0.1 0.5
Ever smoked 3.5 6.1 8.8 3.0 2.8 0.8 -2.7
Basal metabolic rate 0.6 3.5 6.9 -2.6 -1.9 -1.4 1.2
Leg fat percentage (left) 0.8 3.1 6.8 2.6 1.4 0.9 -1.6
Arm fat-free mass (left) 0.8 4.2 8.4 -2.9 -2.4 -1.0 1.2
Number of operations (self-reported) 0.9 1.3 2.7 1.6 0.3 0.3 -1.5
Average weekly beer plus cider intake 11.4 16.4 24.9 2.5 5.0 3.4 -4.8
Irritability 0.5 0.9 1.8 1.1 0.8 1.4 0.2
Risk taking 0.8 1.1 1.6 1.2 1.3 0.1 -1.2
Ever had prostate specific antigen (PSA) test 0.6 0.6 1.3 -0.6 -0.9 -0.4 1.1
Fractured/broken bones in last 5 years 2.5 3.2 9.4 0.2 1.7 0.9 -3.1
Age started oral contraceptive pill 0.1 0.1 0.4 -0.2 -0.0 0.6 -0.2
Diastolic blood pressure, automated reading 0.6 1.7 4.6 -0.2 2.1 -0.0 -1.5
Ever depressed for a whole week 0.2 0.2 0.5 0.1 0.3 0.5 -0.7
Unable to work because of sickness or disability 1.1 1.4 3.6 0.9 0.8 0.8 -1.9
Commuting to job workplace: Cycle 1.5 1.8 3.5 -1.7 -0.5 -1.9 -0.9
Myopia 0.1 0.2 0.5 -0.2 -0.0 0.2 0.7
Vascular/heart problems diagnosed by doctor 0.2 0.4 0.8 -0.7 -0.9 -0.5 0.1
Cholesterol lowering medication 1.4 2.1 6.9 2.6 1.0 0.3 -0.6
Medication: Omeprazole (e.g. Zanprol) 2.2 2.7 3.9 2.0 1.5 1.7 -1.3
Pain experienced in last month 2.6 4.4 8.6 -2.3 -2.9 -0.9 1.7
Supplements: Calcium 0.9 1.0 2.4 -1.2 -1.6 -0.2 0.3
Basal cell carcinoma (self-reported) 0.7 0.8 1.7 -0.8 -0.9 -0.1 1.3
Heart attack/myocardial infarction (self-reported) 1.5 2.0 5.9 2.4 0.5 0.4 1.3
Deep venous thrombosis (DVT) (self-reported) 1.3 1.7 2.3 -0.9 -1.4 -1.5 1.2
Heart disease (siblings) 0.9 1.2 2.4 1.6 1.2 0.3 -0.9
Alcohol drinker status: Previous 0.4 0.5 0.9 -0.8 -0.9 -0.5 0.1
Pack years of smoking 1.2 1.7 2.2 1.5 1.2 1.2 -1.3
Impedance of whole body 1.7 8.7 15.4 3.8 2.1 3.9 0.9
Leg fat mass (left) 0.2 0.6 1.3 1.2 0.6 0.2 -0.9
Arm predicted mass (left) 0.6 3.3 6.6 -2.6 -2.2 -0.9 0.9