Hub : Genes

UNC119B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Gastroesophageal Junction	0.1580	0.0720	6.0e-03	0.009	NA	-0.002	NA	0.004	1.5e-01	NA	3.8e-01	NA	2.3e-01
2	GTEx	Esophagus Muscularis	0.1060	0.0450	2.8e-03	0.106	NA	0.035	NA	0.070	5.7e-07	NA	3.1e-03	NA	4.7e-05
3	GTEx	Nerve Tibial	0.0926	0.0380	1.2e-03	0.075	NA	0.053	NA	0.055	5.2e-06	NA	1.2e-04	NA	8.7e-05
4	GTEx	Thyroid	0.0990	0.0350	2.6e-04	0.071	NA	0.048	NA	0.041	4.3e-06	NA	1.5e-04	NA	4.4e-04
5	YFS	Blood	0.0396	0.0129	1.3e-07	0.026	0.022	0.029	0.024	0.027	5.4e-09	5.5e-08	9.2e-10	1.5e-08	2.2e-09
6	TCGA	Prostate Adenocarcinoma	0.0389	0.0267	5.4e-03	0.017	0.012	0.016	NA	0.017	5.6e-03	1.8e-02	6.8e-03	NA	6.1e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.0	1.5	5.2	1.5	-0.7	1.1	2.3	0.3	0.0
Bipolar Disorder or Schizophrenia	2.7	6.6	14.6	3.4	0.5	3.4	3.8	-0.6	1.1
Depressed Affect (Nagel 2018)	0.2	0.4	1.0	0.5	-1.0	1.0	0.7	0.1	-0.1
Depression (Nagel 2018)	1.3	1.9	5.5	1.3	-1.5	0.5	2.4	0.9	-1.1
Intelligence (Savage-Jansen 2018)	2.4	7.4	18.1	-4.2	-3.3	-2.4	-2.1	1.9	-1.6
Neuroticism (Nagel 2018)	0.1	0.3	1.0	0.5	-0.2	1.0	-0.2	-0.7	-0.2
Schizophrenia (2018)	2.9	6.1	12.6	3.2	1.3	3.5	3.0	-1.0	1.4
Schizophrenia vs Biploar Disorder	0.6	0.7	2.1	0.9	1.4	0.9	-0.0	-0.9	0.2
Worry (Nagel 2018)	0.2	0.4	1.1	-0.2	-0.9	-0.2	-0.8	0.1	-1.0
Alzheimer’s Disease (in mother)	0.7	0.9	3.5	0.3	0.3	0.2	-0.8	-1.0	1.9
Alzheimer’s Disease (in father)	0.2	0.3	0.7	0.9	-0.3	0.6	0.5	0.3	-0.0
Alzheimer’s Disease (including proxy)	0.4	0.5	1.8	0.7	-0.3	0.4	0.1	-0.8	1.4
Crohns Disease (2017)	0.5	1.0	2.1	0.7	0.8	1.4	1.5	0.3	0.7
Irritable Bowel Disease (IBD)	0.2	0.5	1.0	0.1	0.9	0.3	1.0	0.9	-0.4
Ulcerative Colitis (UC)	0.3	0.6	1.4	-0.3	0.7	-0.8	0.1	1.1	-1.2
Major Depression (MDD)	0.6	0.8	2.2	-0.1	-1.5	0.3	1.5	0.2	0.1
Reaction Time	2.1	3.9	11.3	2.4	0.7	2.1	3.4	-0.9	0.5
Verbal and Numeric Reasoning (VNR)	1.6	3.9	7.8	-2.8	-2.5	-1.5	-1.8	1.7	-0.9
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	1.9	2.5	6.2	2.5	1.5	1.1	1.6	-0.5	1.6
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	2.2	3.1	4.3	-2.0	-2.0	-1.8	-0.7	2.1	-1.7
Bipolar Disorder (2011)	0.7	0.7	1.7	0.3	-1.3	0.8	1.1	0.7	-0.1
Body Mass Index (BMI) (2010)	0.2	0.3	1.1	0.8	-0.0	0.3	1.0	-0.2	-0.2
Coronary Artery Disease (CAD)	2.5	3.0	8.2	2.9	2.3	1.5	1.0	-0.8	0.9
Crohns Disease (2012)	1.1	1.8	4.7	0.7	1.2	2.2	0.6	-0.7	1.8
Mean Putamen Volume	4.0	4.6	12.4	-1.6	-1.8	-1.9	0.1	2.5	-3.5
Fasting Glucose	0.4	0.5	1.2	-0.3	-1.1	0.0	-0.8	0.9	0.2
HbA1C	0.5	0.5	1.9	0.8	-0.2	0.6	1.4	-0.5	0.4
HDL Cholesterol	1.0	1.6	3.0	1.5	1.5	0.7	1.7	-0.8	1.1
LDL Cholesterol	1.1	1.8	6.8	2.6	0.7	0.1	1.5	1.0	0.2
Lupus	0.8	1.3	3.8	-1.2	-1.3	-0.6	0.3	0.4	-1.9
Neuroticism (2016)	0.9	1.3	3.2	1.8	0.5	1.3	-0.8	-0.7	1.3
Primary Biliary Cirrhosis	1.2	1.7	4.0	1.7	0.8	1.4	2.0	-0.4	0.5
Rheumatoid Arthritis	0.6	0.9	4.6	0.0	0.4	0.1	-2.1	0.5	0.4
Schizophrenia (2014)	2.5	5.5	12.0	3.5	1.5	2.9	2.5	-1.3	1.6
Triglycerides	0.2	0.4	1.6	0.8	-0.2	0.3	1.3	0.2	0.1
Type 2 Diabetes (T2D) (2012)	1.6	1.8	5.2	2.3	0.3	0.5	2.3	0.1	-0.5
Ulcerative Colitis	0.3	0.4	0.9	0.4	1.0	-0.1	0.2	0.4	-0.9
Blood Eosinophil Count	2.1	16.4	34.3	-4.5	-3.6	-3.8	-5.9	3.4	-2.1
Blood Platelet Count	0.7	7.7	21.3	-4.6	-3.0	-2.3	-3.0	0.8	0.9
Blood Red Count	16.3	157.7	305.6	9.9	17.5	11.4	-0.2	-15.4	13.3
Blood White Count	0.8	5.8	8.8	-3.0	-2.3	-2.9	-1.6	2.0	-2.3
Heel T-Score	0.1	1.0	3.6	0.1	1.9	-0.8	-1.0	-0.0	0.8
BMI	0.2	1.2	3.8	1.4	-0.8	0.5	2.0	0.8	0.2
Height	1.3	25.3	115.6	-3.0	-1.9	-1.9	-10.8	4.2	-1.4
Waist Hip Ratio (WHR)	0.3	1.2	4.1	0.5	-2.0	-1.0	0.5	0.7	-1.2
Systolic Blood Pressure	1.4	7.0	13.1	-3.0	-2.4	-3.6	-2.0	2.4	-2.1
Smoking Status	6.0	14.5	35.5	6.0	1.7	4.0	4.8	-1.4	2.7
Allergy or Eczema	5.0	13.2	25.7	-5.1	-3.3	-3.9	-4.9	1.7	-0.3
Cardiovascular Disease	0.5	1.6	5.4	1.2	-0.3	-0.6	2.3	0.5	-1.5
Hypothyroidism (self reported)	1.4	3.2	8.7	-2.0	-3.0	-1.1	-1.9	1.2	0.1
Respiratory disease	2.0	4.5	6.4	-2.2	-2.1	-2.2	-2.5	2.4	-0.8
Type 2 Diabetes (T2D) (2018)	1.8	3.4	4.9	0.8	-1.9	-1.5	2.0	2.2	-2.2
Lung FEV1/FVC ratio	0.4	2.2	12.2	0.2	-0.6	-0.6	3.5	0.3	-0.6
Lung FVC	7.0	35.8	52.3	6.4	7.2	6.3	-0.9	-5.9	6.8
Neuroticism	0.2	0.5	1.3	0.8	-1.1	0.9	0.0	0.0	0.0
Chronotype (morning person)	1.1	2.5	6.8	-2.5	0.5	-0.8	-2.6	-1.1	0.0
Hair Pigment	0.1	3.4	7.2	-2.7	-1.0	-2.4	-2.0	0.1	-1.6
Tanning	0.1	1.1	3.5	1.4	1.9	0.8	-0.3	-0.4	0.2
Hand grip strength (left)	0.1	0.2	0.6	0.1	0.6	-0.3	-0.6	-0.2	0.8
Number of treatments/medications taken	0.9	1.6	6.6	1.2	-0.5	0.6	2.6	-0.0	-0.8
Average weekly spirits intake	1.2	1.5	3.7	-1.9	-1.0	-0.8	0.5	0.8	-1.6
Sensitivity / hurt feelings	0.2	0.3	1.1	-0.1	-0.6	0.3	-1.1	-0.4	0.0
Frequency of depressed mood in last 2 weeks	0.9	1.3	5.1	1.3	-0.4	0.7	2.3	-0.2	-0.7
Hearing difficulty/problems: Yes	0.8	1.2	3.9	-0.3	-0.9	-0.6	0.2	1.4	-2.0
Relative age of first facial hair	2.8	5.7	13.3	-2.7	-2.6	-2.3	-3.6	0.2	1.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.7	1.0	0.4	1.0	-0.2	-1.7	0.4
Ever used hormone-replacement therapy (HRT)	2.8	3.6	5.4	1.5	2.1	1.3	-1.7	-2.2	2.3
Ever had hysterectomy (womb removed)	0.2	0.2	0.7	0.5	0.2	-0.2	0.8	-0.5	-0.1
Systolic blood pressure, automated reading	0.7	1.9	4.8	-1.4	-0.6	-2.2	-1.9	0.8	-0.5
Eye problems/disorders: Diabetes related eye disease	2.3	2.5	5.8	-0.2	-1.6	-0.9	1.5	1.9	-2.4
Angina	0.6	0.8	3.0	1.7	1.0	0.5	-0.2	-0.1	-0.8
Medication for hormone replacement therapy	0.2	0.2	0.5	0.6	0.7	-0.2	-0.1	0.0	-0.4
Vitamin and mineral supplements	0.6	0.9	1.5	-1.1	0.2	-0.7	-1.2	1.2	-0.7
Supplements: Zinc	3.3	3.5	6.6	0.8	1.3	2.4	2.6	-2.3	1.2
Medication: Co-codamol	2.8	3.2	12.4	1.9	0.4	1.3	3.5	-1.1	0.1
Medication: Metformin	0.8	1.2	2.9	-0.1	-0.8	-1.0	0.2	1.7	-1.6
Diabetes (father)	2.8	3.5	6.8	-0.4	-2.5	-2.2	0.2	2.6	-1.6
Diabetes (mother)	1.6	2.1	5.3	2.3	1.4	0.8	2.1	-0.7	-0.4
Severe depression (siblings)	2.3	2.6	5.6	-0.1	-1.9	-0.9	1.2	2.4	-2.0
Pack years adult smoking proportion	0.5	0.8	1.6	1.3	-0.5	-0.5	0.8	1.0	-1.0
Impedance of leg (right)	0.3	1.3	2.9	0.4	0.8	1.7	-1.0	-1.7	0.1
Leg fat-free mass (left)	0.7	3.7	8.8	-1.6	-1.7	-1.8	-2.1	3.0	-1.0
Trunk fat percentage	0.3	1.4	3.1	1.8	0.5	1.8	0.5	-0.4	1.1
Hand grip strength (right)	0.2	0.5	1.4	-1.0	-0.0	-1.2	-0.5	0.6	-0.1
Townsend deprivation index at recruitment	1.1	1.6	4.1	2.0	1.0	1.1	1.1	-1.0	0.9
Current tobacco smoking	1.4	2.3	9.9	1.1	-1.0	0.1	3.1	1.3	-0.3
Average weekly fortified wine intake	1.0	1.2	2.9	-0.8	-0.5	-0.9	0.7	1.5	-1.7
Maternal smoking around birth	0.5	0.7	2.1	1.4	-0.2	-0.4	-0.4	1.3	0.1
Fed-up feelings	0.6	1.1	3.8	1.2	-0.8	0.9	1.9	-0.2	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	4.5	0.6	-2.0	-0.2	2.1	1.1	-1.1
Relative age voice broke	2.2	3.3	8.1	-2.2	-1.5	-1.0	-2.8	-0.6	1.8
Taking other prescription medications	0.7	1.1	4.0	2.0	-0.8	0.9	0.8	0.4	0.1
Age when periods started (menarche)	2.3	5.4	16.2	-3.2	-2.0	-1.2	-4.0	0.8	-0.4
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.4	1.1	1.2	0.2	-0.5	-0.7	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.6	-0.7	0.3	-0.8	-0.2	0.7	-0.4
Tinnitus: Yes, but not now, but have in the past	2.0	2.2	3.5	1.9	1.0	1.9	1.4	-1.1	1.4
Qualifications: CSEs or equivalent	1.3	1.7	7.7	0.8	-1.0	-0.1	2.8	0.7	0.5
Serious illness, injury or assault to yourself	0.1	0.2	0.6	0.8	0.1	-0.3	0.0	0.5	-0.1
High blood pressure	0.3	0.9	3.2	0.2	-0.6	-0.8	1.1	0.2	-1.8
Hayfever, allergic rhinitis or eczema	2.9	6.3	13.9	-3.7	-2.5	-3.1	-2.7	1.0	-0.2
Multivitamins +/- minerals	0.5	0.6	2.6	0.5	-0.8	-0.2	1.6	-0.4	0.2
Stomach or abdominal pain in last month	1.9	2.4	7.4	2.7	0.2	1.4	2.0	-0.2	0.9
Supplements: Glucosamine	1.2	1.5	4.7	-0.3	0.6	0.9	1.2	-2.2	1.4
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.9	1.4	0.1	1.0	0.6	0.1	1.0
Medication: Atenolol	2.0	2.6	10.0	1.8	0.5	0.7	3.2	-0.2	-1.1
Medication: Levothyroxine sodium	0.8	1.4	2.9	-0.9	-1.3	-1.7	-1.4	0.9	-0.6
Sitting height	0.4	2.6	6.2	-1.2	-0.4	-0.7	-2.5	2.3	-1.4
Chronic bronchitis/emphysema (father)	0.5	0.6	1.5	1.2	0.6	0.9	-0.1	-0.4	0.7
High blood pressure (mother)	0.3	0.4	1.8	-1.3	-0.0	-0.2	-0.3	-0.5	-0.4
Body mass index (BMI)	0.6	2.6	5.7	2.2	1.0	1.4	2.4	-0.5	1.4
Impedance of leg (left)	0.4	2.0	4.2	0.8	1.1	1.9	-1.3	-2.1	0.6
Leg predicted mass (left)	0.7	3.9	9.1	-1.6	-1.7	-1.8	-2.1	3.0	-1.0
Trunk fat mass	0.1	0.4	0.9	0.9	-0.0	0.9	-0.3	0.5	0.5
Waist circumference	0.1	0.3	1.2	0.6	-0.6	-0.2	-0.0	1.1	-0.2
Number of incorrect matches in round	3.0	4.9	8.7	3.0	2.2	2.5	1.7	-2.0	1.8
Past tobacco smoking	4.5	8.3	15.2	-3.9	-2.1	-3.5	-2.1	2.4	-2.8
Alcohol usually taken with meals	1.4	2.2	11.0	-0.8	0.7	-0.7	-3.3	0.5	0.5
Nervous feelings	2.3	4.2	7.4	-2.7	-2.2	-2.1	-2.0	0.6	-1.9
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	3.7	0.1	-1.9	-0.6	1.1	1.4	-1.3
Hearing difficulty/problems with background noise	0.4	0.7	1.2	-0.5	-0.9	-0.6	-1.1	1.1	-0.8
Hair/balding pattern: Pattern 2	0.5	0.6	1.0	-1.0	-1.0	0.3	-0.7	-0.8	0.6
Had menopause	0.8	1.0	5.4	0.3	0.2	0.5	-2.3	0.4	0.5
Had other major operations	1.8	2.2	5.9	2.4	1.0	1.1	1.4	-1.5	0.7
Forced vital capacity (FVC)	1.8	7.1	9.3	1.7	2.9	3.0	-3.0	-2.1	2.9
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.0	-0.6	0.4	-0.7	-0.3	1.0	-0.2
Ever unenthusiastic/disinterested for a whole week	2.1	2.5	9.2	1.6	-0.2	1.5	3.0	-1.0	-0.0
Qualifications: None of the above	2.5	5.3	14.7	3.8	1.9	2.1	0.7	-2.3	1.8
Financial difficulties in last 2 years	2.8	3.8	15.4	1.7	-0.9	-0.0	3.9	1.1	-1.6
Mouth/teeth dental problems	0.3	0.5	1.2	-0.3	0.6	0.7	-0.9	-0.4	1.1
Heart attack	2.5	3.2	8.2	2.9	2.0	2.0	-0.6	-0.8	1.4
Allergy	3.3	7.5	18.6	4.3	3.2	3.2	1.8	-1.2	1.2
Pain all over the body in last month	0.4	0.4	1.0	-0.4	-0.7	-0.3	-0.8	0.1	-1.0
Diabetes (self-reported)	2.0	3.1	4.8	-0.0	-2.0	-2.1	0.7	2.2	-2.1
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.1	-1.1	-0.2	-0.9	-0.8	-0.3	-0.1
Medication: Ramipril	0.2	0.3	0.7	-0.1	-0.7	-0.1	-0.7	0.3	-0.8
Medication: Simvastatin	0.7	1.0	2.9	1.7	0.8	0.6	1.4	-0.3	-0.5
Fluid intelligence score	2.3	4.7	7.8	-2.8	-2.2	-2.1	-2.4	1.7	-1.6
Illnesses of siblings	1.0	1.5	3.1	-1.8	-1.2	-1.3	-1.5	0.3	0.5
Neuroticism score	0.1	0.2	0.9	0.3	-1.0	0.5	0.4	0.0	0.1
Weight	0.1	0.6	1.6	0.1	-0.3	0.1	-1.3	1.3	0.3
Impedance of arm (right)	0.1	0.5	1.2	-0.7	-1.0	0.2	-1.1	-0.0	-0.6
Arm fat percentage (right)	0.4	1.5	4.5	1.4	0.2	1.1	2.1	-0.6	0.9
Trunk fat-free mass	1.1	6.2	9.8	-2.7	-1.9	-2.4	-3.1	2.9	-1.5
Hip circumference	0.2	0.7	1.7	0.3	0.9	0.7	-1.3	0.7	0.7
Time employed in main current job	0.3	0.4	0.9	-0.0	0.2	-0.6	0.9	1.0	-0.2
Alcohol intake versus 10 years previously	3.6	5.4	17.6	4.2	1.8	2.7	1.2	-1.2	1.0
Father’s age at death	1.5	2.0	7.8	-0.6	0.6	0.2	-2.8	-0.9	1.7
Worrier / anxious feelings	1.4	2.7	3.8	2.0	1.1	1.9	1.4	-1.7	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	2.8	-0.1	-1.5	-0.7	1.0	0.9	-1.7
Falls in the last year	0.5	0.7	1.7	-1.3	-0.8	-1.0	-0.7	-0.3	-0.5
Hair/balding pattern: Pattern 3	0.3	0.5	2.0	0.9	0.3	0.0	1.4	0.3	-0.2
Number of live births	0.9	1.3	3.1	-0.7	-1.4	-1.2	-0.5	1.8	-0.8
Forced expiratory volume in 1-second (FEV1)	1.7	5.6	7.8	1.8	2.8	2.7	-1.9	-2.2	2.7
Pulse rate	2.7	4.5	8.4	-2.2	-1.4	-2.9	-2.0	1.8	-2.1
Happiness	2.5	3.1	6.4	-1.5	-1.8	-2.5	-0.6	1.5	-2.0
Noisy workplace	6.3	7.8	13.0	3.6	1.9	3.3	2.0	-2.4	3.1
Qualifications: A levels/AS levels or equivalent	1.7	3.8	9.9	-3.1	-1.0	-2.0	-1.4	1.0	-2.3
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	4.0	-0.5	-0.8	-0.3	2.0	0.6	-1.4
Mouth/teeth dental problems: Dentures	0.7	1.2	3.4	0.2	-1.5	-0.6	1.8	0.0	-1.0
Asthma	2.8	5.5	8.9	-2.6	-3.0	-2.5	-1.6	2.7	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.8	0.4	0.5	0.4	1.4	-0.3	0.2
Medication: Cholesterol lowering	0.8	1.3	2.9	0.9	0.6	1.1	1.7	0.5	-1.4
Depression (self-reported)	4.5	5.3	12.9	3.6	0.4	2.7	2.5	-1.5	1.7
Medication: Lansoprazole	1.1	1.3	3.2	1.8	0.5	1.0	1.8	-0.1	-0.0
Prospective memory result	0.3	0.4	0.7	0.6	-0.7	-0.8	0.2	0.7	-0.5
Lung cancer (father)	0.8	1.0	2.7	1.6	1.2	1.1	-0.0	-0.5	0.6
Illnesses of mother	0.6	0.7	2.7	-0.1	-0.7	-0.7	-0.9	1.7	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	7.0	10.5	2.3	3.2	2.7	-2.3	-2.5	2.8
Pulse wave Arterial Stiffness index	0.9	1.1	2.3	-0.7	-1.5	-1.5	-0.4	0.8	-0.7
Impedance of arm (left)	0.1	0.6	1.5	0.4	-0.3	0.9	-1.2	-0.9	0.1
Arm fat mass (right)	0.1	0.4	0.9	0.7	-0.2	0.5	0.9	0.5	0.6
Trunk predicted mass	1.1	6.4	10.1	-2.7	-1.9	-2.5	-3.2	3.0	-1.5
Standing height	1.7	17.3	59.8	-4.0	-2.5	-2.3	-7.7	3.5	-2.0
Length of working week for main job	0.9	1.0	2.4	-1.1	-1.1	-1.6	-0.8	0.2	-0.7
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.0	0.1	0.3	-0.2	-0.4	0.1
Breastfed as a baby	0.7	0.9	2.5	-1.6	-0.5	-1.2	-0.4	-0.1	-0.8
Tense / ‘highly strung’	0.9	1.4	3.2	1.4	-0.3	1.4	-1.8	-0.6	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	3.0	4.6	9.9	3.1	0.1	3.1	2.7	-0.7	0.4
Hair/balding pattern: Pattern 4	0.3	0.8	1.9	0.9	0.8	1.4	0.9	-0.0	0.6
Birth weight of first child	0.3	0.5	1.1	0.9	-0.5	1.1	-0.1	0.2	0.8
Peak expiratory flow (PEF)	0.7	1.5	3.0	1.0	0.9	1.3	-0.4	-1.7	1.7
Pulse wave reflection index	0.1	0.1	0.2	0.1	-0.3	-0.0	-0.5	0.1	0.3
Ever highly irritable/argumentative for 2 days	1.0	1.2	4.1	0.3	-0.9	-0.3	2.0	0.6	-1.4
Loud music exposure frequency	0.5	0.6	1.6	0.1	1.3	-0.4	-0.1	-1.1	-0.5
Qualifications: O levels/GCSEs or equivalent	2.8	4.4	10.7	-3.3	-1.1	-2.1	-1.6	1.7	-2.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.6	0.5	0.8	-0.3	-0.4	0.1	-0.2
Blood clot in the leg (DVT)	1.7	2.2	10.4	0.2	-0.6	1.0	3.2	0.8	-0.8
Medication: Paracetamol	1.6	2.7	5.3	1.2	1.4	1.5	2.2	-2.3	0.5
Headache pain in last month	0.5	0.8	3.8	0.4	0.5	-0.2	1.9	0.2	-0.8
Medication for cholesterol, blood pressure or diabetes	1.9	3.1	7.4	-0.2	1.2	0.7	-2.4	-1.9	2.7
Glaucoma (self-reported)	0.1	0.1	0.4	-0.5	-0.6	0.0	-0.1	0.4	0.1
Gout (self-reported)	2.2	3.0	4.8	1.6	2.2	2.0	0.7	-2.0	1.6
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	4.9	-1.5	-2.2	-1.2	-1.3	0.5	0.0
Medication: Amlodipine	0.2	0.3	1.2	-0.0	-1.1	-0.5	0.6	0.2	0.2
Medication: Ventolin 100micrograms inhaler	2.0	2.6	5.1	-1.2	-2.1	-1.7	-0.2	2.2	-1.4
Birth weight	0.5	1.0	4.4	-0.9	0.5	-0.1	-2.1	-0.5	0.5
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	0.6	-0.3	0.6	-0.1	0.1	0.2
High blood pressure (siblings)	0.8	1.1	2.2	1.4	1.0	1.0	1.5	-0.8	0.0
Forced vital capacity (FVC), Best measure	2.5	9.3	12.6	2.4	3.5	3.1	-3.5	-2.3	3.2
Body fat percentage	0.4	1.8	3.9	2.0	0.8	1.8	1.0	-0.7	1.3
Leg fat percentage (right)	0.7	2.6	5.6	2.4	1.1	1.8	1.8	-0.8	1.2
Arm fat-free mass (right)	0.5	2.6	7.6	-1.0	-0.5	-1.1	-2.8	2.2	-0.5
Exposure to tobacco smoke outside home	0.1	0.1	0.2	-0.2	-0.3	-0.4	-0.4	-0.4	0.1
Comparative body size at age 10	0.3	1.0	2.7	1.6	1.1	0.9	0.9	0.2	-0.4
Number of full brothers	1.8	2.3	3.7	1.3	1.9	1.6	-0.1	-1.9	1.6
Worry too long after embarrassment	0.3	0.5	2.4	-0.0	0.5	-0.4	-1.6	-0.3	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	3.8	1.9	-1.6	0.8	1.1	1.0	-1.1
Wheeze or whistling in the chest in last year	0.4	0.7	1.3	0.6	-1.0	1.1	0.8	-0.1	1.1
Number of children fathered	2.7	3.1	6.6	1.7	1.8	1.4	-1.7	-1.0	2.6
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.3	0.2	-1.8	0.3	0.9	1.7	-0.7
Age at first live birth	2.3	4.0	8.0	-2.7	-1.7	-1.7	0.1	1.8	-2.8
Pulse wave peak to peak time	0.7	0.8	2.0	0.4	1.4	1.3	-0.2	-0.6	0.6
Health satisfaction	1.7	2.3	4.9	-1.3	-1.3	-1.6	-0.5	1.6	-2.2
Shortness of breath walking on level ground	0.5	0.6	1.1	-0.4	-0.7	-0.4	-1.0	0.7	-1.0
Qualifications: College or University degree	1.3	4.2	8.8	-3.0	-2.3	-2.2	-1.1	1.5	-1.6
Eye problems/disorders: None of the above	1.2	1.4	2.4	0.7	0.8	1.2	1.5	-1.5	0.8
Mouth/teeth dental problems: Loose teeth	0.8	1.0	1.3	-0.6	-1.0	-1.1	-1.1	1.1	-1.0
Emphysema/chronic bronchitis	3.8	4.3	5.7	2.2	2.2	2.4	1.3	-2.3	1.8
Medication for pain relief, constipation, heartburn	3.2	5.4	7.7	-2.8	-2.4	-2.5	-1.7	2.7	-1.4
Neck or shoulder pain in last month	1.9	2.8	11.4	1.7	0.4	1.4	3.4	-0.5	0.0
Medication: Blood pressure	1.4	2.4	4.9	0.3	-1.3	-1.0	2.2	1.5	-2.2
Angina (self-reported)	0.6	0.8	3.0	1.7	1.1	0.5	-0.1	-0.2	-0.7
Migraine (self-reported)	1.5	1.9	8.7	-0.0	0.1	0.4	3.0	-0.3	-1.5
Medication: Ibuprofen	0.2	0.2	1.1	0.0	0.4	0.3	1.0	-0.2	0.2
Medication: Allopurinol	0.9	1.2	2.7	1.0	1.6	0.9	0.3	-1.4	0.8
Medication: Omeprazole	0.5	0.6	1.4	1.2	0.8	1.0	0.3	-0.3	0.2
Medication: Seretide 50 evohaler	0.9	1.0	3.1	1.1	0.5	0.6	1.8	-0.8	0.6
Mean time to correctly identify matches	3.6	6.9	12.1	3.5	1.4	3.0	3.3	-2.1	1.9
Heart disease (mother)	0.5	0.6	1.5	0.9	0.5	0.8	1.2	-0.4	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.4	0.3	0.6	1.2	1.6	-1.1	0.9
Whole body fat mass	0.1	0.3	0.9	1.0	0.2	0.8	-0.1	0.5	0.5
Leg fat mass (right)	0.2	0.7	2.2	1.5	0.5	1.1	0.6	0.2	0.7
Arm predicted mass (right)	0.5	2.5	6.0	-1.2	-0.7	-1.3	-2.4	2.2	-0.7
Pulse rate, automated reading	0.4	1.2	2.4	-0.5	-0.8	-1.5	1.0	1.2	-1.1
Alcohol intake frequency.	0.7	1.7	3.6	1.5	1.0	1.2	1.9	-1.1	-1.0
Comparative height size at age 10	0.4	2.3	10.0	0.3	0.3	0.4	-3.2	1.5	-0.9
Number of full sisters	0.9	1.0	3.1	1.8	0.8	1.1	-0.9	-0.6	0.5
Suffer from ‘nerves’	0.1	0.2	0.9	0.0	-0.2	0.1	-0.4	-1.0	-0.3
Overall health rating	0.5	1.0	1.8	1.2	-1.4	-0.1	0.9	0.8	-1.2
Chest pain or discomfort	1.5	2.2	6.0	2.4	0.7	2.0	1.0	-1.0	0.7
Had major operations	0.5	0.6	2.8	1.7	0.2	0.6	0.5	-0.1	-0.4
Age at last live birth	0.3	0.4	1.1	-0.7	-0.5	-0.1	0.8	0.0	-1.0
Family relationship satisfaction	2.3	2.8	5.6	-1.7	-1.9	-2.4	0.2	1.0	-1.9
Leg pain on walking	0.6	0.8	1.6	-0.7	-1.1	-0.7	0.1	1.3	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.9	0.5	0.7	1.0	-0.4	-0.7	0.3
Commuting to job workplace: Car/motor vehicle	2.9	3.3	5.1	2.0	1.8	2.2	-0.6	-1.6	2.3
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	6.0	-0.1	0.8	0.6	-2.5	-1.1	2.2
Medication: Aspirin	1.5	1.9	5.6	2.4	1.5	1.2	0.3	-1.2	0.8
Supplements: Vitamin C	0.6	0.8	1.4	1.1	0.7	1.2	-0.2	-0.7	1.0
Knee pain experienced in last month	0.4	0.6	2.5	0.4	0.1	0.7	0.1	-0.5	1.6
Hypertension (Self-reported)	0.5	1.3	3.6	0.0	-0.8	-1.2	1.3	0.6	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	0.3	-0.1	-0.5	-0.5	-0.1	-0.4
Illnesses of father: Heart disease	0.5	0.7	1.8	1.4	0.4	1.0	1.1	0.2	0.4
Illnesses of siblings: Diabetes	0.8	1.0	2.9	1.7	1.0	0.5	0.9	0.7	-0.7
Smoking status: Previous	4.1	6.1	10.4	3.2	2.1	3.0	0.9	-2.4	2.5
Forced expiratory volume in 1-second (FEV1), predicted	2.5	5.2	10.1	-2.6	-2.2	-2.0	-3.2	2.1	-0.9
Whole body fat-free mass	0.9	5.2	9.2	-2.2	-1.8	-2.2	-2.8	3.0	-1.2
Leg fat-free mass (right)	0.6	3.4	8.0	-1.5	-1.6	-1.8	-2.1	2.8	-0.7
Arm fat percentage (left)	0.6	2.3	5.1	2.0	0.6	1.5	2.2	-0.9	1.1
Average weekly red wine intake	0.6	0.9	2.1	-1.0	-1.4	-0.4	-0.3	1.4	-0.1
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	0.6	-0.5	-0.4	0.4	0.7	-0.2
Mood swings	0.3	0.5	0.8	0.9	0.4	0.9	0.5	-0.4	0.8
Loneliness, isolation	1.4	2.0	5.7	1.2	-1.4	1.5	2.4	0.1	0.6
Long-standing illness, disability or infirmity	1.1	1.7	5.6	2.4	1.0	0.8	0.9	-1.3	0.8
Ever had bowel cancer screening	0.6	0.7	2.7	1.6	-0.1	0.3	-0.2	1.0	0.3
Diabetes diagnosed by doctor	2.2	3.6	6.6	0.3	-1.9	-2.0	1.6	2.3	-2.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.7	0.9	-0.0	-0.2	0.1	0.3	-0.4
Friendships satisfaction	1.1	1.4	2.5	-1.6	-1.6	-1.1	0.4	0.8	-1.2
Qualifications: nursing, teaching	1.0	1.6	3.8	0.8	1.1	2.0	1.4	-0.7	1.3
Commuting to job workplace: Walk	0.4	0.4	1.8	-1.3	-0.2	0.0	-0.4	0.3	-0.6
Eye problems/disorders: Cataract	0.4	0.5	1.9	0.6	-0.2	-0.4	-0.5	1.4	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.2	0.6	0.5	0.4	1.1	-0.4	-0.3
Medication for cholesterol	0.5	0.8	2.0	-0.7	0.4	1.2	1.4	-0.2	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.8	3.0	0.7	0.2	0.6	-1.7	0.4	0.7
Back pain experienced in last month	1.9	2.8	6.7	1.9	1.9	2.6	1.2	-0.8	0.6
Mineral and other dietary supplements	1.9	2.5	4.0	-1.2	-0.7	-1.4	-2.0	2.0	-1.8
Breast cancer (self-reported)	0.9	1.1	2.0	-0.6	-1.4	-1.0	-1.4	1.1	-0.5
Asthma (self-reported)	2.2	4.4	7.5	-2.3	-2.7	-2.3	-1.3	2.5	-0.9
Osteoporosis (self-reported)	2.0	2.5	4.3	2.1	1.9	2.1	0.8	-1.5	-0.2
Osteoarthritis (self-reported)	2.6	3.3	5.4	1.7	1.9	2.3	-0.3	-2.0	2.0
Medication: Aspirin	1.3	1.7	5.4	2.3	1.4	1.0	0.2	-0.9	1.0
Medication: Gliclazide	0.7	0.8	2.1	-0.7	-1.5	-1.2	-0.3	0.5	-0.6
Illnesses of father: None of the above (group 1)	0.4	0.5	1.6	-1.1	-0.0	-0.1	-1.3	-0.1	0.0
Smoking status: Current	1.7	2.7	12.5	1.6	-0.4	0.7	3.5	0.9	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.0	8.4	14.0	3.6	3.1	3.7	1.1	-2.5	2.6
Whole body water mass	0.9	5.2	9.3	-2.2	-1.8	-2.2	-2.7	3.1	-1.2
Leg predicted mass (right)	0.7	3.6	8.1	-1.6	-1.6	-1.8	-2.2	2.9	-0.7
Arm fat mass (left)	0.1	0.4	0.9	0.9	-0.0	0.6	0.7	0.3	0.7
Number of self-reported non-cancer illnesses	0.8	1.3	3.6	1.5	0.1	1.0	1.9	-1.1	-0.4
Average weekly champagne plus white wine intake	0.9	1.3	3.1	-1.6	-0.2	-1.4	-1.8	0.2	-0.3
Miserableness	0.4	0.7	2.8	0.5	-0.5	1.0	1.7	-0.1	-0.2
Guilty feelings	0.8	1.1	3.0	0.9	0.8	1.2	1.7	-0.9	0.2
Wears glasses or contact lenses	0.6	0.7	2.3	-0.2	-0.4	-0.6	-1.5	0.8	-0.7
Ever taken oral contraceptive pill	0.5	0.6	1.1	-0.9	0.1	-1.0	0.7	-0.1	-1.1
Hearing aid user	1.5	1.7	4.9	2.2	0.7	1.8	1.1	-0.3	0.4
Mother’s age at death	0.8	1.0	3.4	-1.5	-0.6	0.1	1.9	0.1	-0.1
Financial situation satisfaction	0.5	0.6	1.9	-0.1	-0.4	-0.2	1.4	-0.0	-1.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.8	0.2	0.5	-0.9	-0.1	1.3	-1.1
Commuting to job workplace: Public transport	4.4	5.2	10.1	-2.4	-2.4	-2.6	-0.2	1.7	-3.2
Eye problems/disorders: Glaucoma	0.3	0.3	0.9	-0.2	0.2	0.3	-0.9	-0.5	0.8
Medication: Blood pressure	0.4	0.8	2.7	-0.4	-0.8	-1.0	-1.6	0.0	-0.6
Pain type(s) experienced in last month: Hip pain	1.6	2.0	7.6	2.8	-0.2	1.2	1.4	0.1	0.8
Supplements: Fish oil (including cod liver oil)	1.0	1.4	3.7	0.9	0.7	0.7	0.7	-1.5	1.9
High cholesterol (Self-reported)	1.9	3.3	9.2	2.4	1.4	1.4	3.0	0.0	-1.0
Medication: Bendroflumethiazide	0.5	0.7	3.2	-0.4	0.2	-0.9	-1.8	-0.0	-0.4
Medication: Paracetamol	1.6	2.4	5.6	0.7	1.8	1.6	1.5	-2.4	0.8
Medication: Lisinopril	0.7	0.9	1.4	-0.8	-0.8	-1.2	0.4	1.0	-1.2
Medication: Atorvastatin	0.7	0.8	2.0	1.1	-0.9	0.2	1.4	1.0	-0.3
Illnesses of father: High blood pressure	0.3	0.4	1.4	0.6	0.5	-0.4	-0.1	-1.2	0.5
Alcohol drinker status: Never	0.2	0.2	0.8	-0.3	0.7	-0.0	-0.1	-0.2	-0.9
Ever smoked	3.0	5.3	7.7	2.6	1.6	2.8	1.9	-2.1	2.6
Basal metabolic rate	0.7	3.9	7.7	-1.8	-1.5	-1.8	-2.5	2.8	-0.9
Leg fat percentage (left)	0.8	2.9	6.2	2.5	1.2	1.9	1.8	-0.9	1.4
Arm fat-free mass (left)	0.6	3.1	7.2	-1.5	-0.9	-1.3	-2.7	2.4	-0.7
Number of operations (self-reported)	3.5	5.2	14.3	3.8	1.2	2.4	2.0	-2.1	1.2
Average weekly beer plus cider intake	0.2	0.3	1.2	0.8	-0.1	0.2	-0.1	-0.1	1.1
Irritability	0.2	0.4	1.8	-0.1	0.5	0.1	-1.4	-0.6	0.2
Risk taking	0.3	0.5	2.1	1.5	0.2	-0.0	0.5	0.1	-0.6
Ever had prostate specific antigen (PSA) test	1.0	1.1	2.6	-0.8	-1.0	-1.4	0.6	0.6	-1.6
Fractured/broken bones in last 5 years	0.5	0.6	2.1	-0.2	-0.6	-0.7	1.4	-0.2	-0.8
Age started oral contraceptive pill	0.7	0.9	3.1	0.2	0.2	0.7	-1.2	-0.3	1.8
Diastolic blood pressure, automated reading	0.1	0.5	1.6	-0.9	-0.0	-1.2	-0.6	-0.2	0.1
Ever depressed for a whole week	0.7	0.8	3.4	0.5	-0.8	0.6	1.8	-0.3	-0.2
Unable to work because of sickness or disability	0.5	0.6	2.3	1.5	0.9	0.6	0.1	-0.3	-0.2
Commuting to job workplace: Cycle	0.5	0.6	2.0	-0.4	-0.9	-0.7	1.4	0.0	-0.3
Myopia	2.0	2.8	4.8	-1.2	-1.5	-2.2	-1.8	2.1	-1.0
Vascular/heart problems diagnosed by doctor	0.3	0.7	2.4	-0.9	0.1	0.2	-1.0	0.0	1.5
Cholesterol lowering medication	1.2	1.7	7.8	2.8	1.2	0.2	0.0	-0.7	0.9
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.7	1.1	0.9	1.3	0.4	-1.2	0.8
Pain experienced in last month	0.1	0.1	0.3	-0.5	0.1	0.3	-0.6	-0.1	0.3
Supplements: Calcium	0.1	0.1	0.3	-0.4	-0.3	-0.1	-0.5	-0.1	0.2
Basal cell carcinoma (self-reported)	0.4	0.5	1.4	-0.1	-0.3	1.1	-0.3	0.5	1.2
Heart attack/myocardial infarction (self-reported)	1.4	1.8	4.8	2.2	1.6	1.4	-0.9	-0.4	0.7
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	11.2	0.1	-0.7	1.0	3.3	0.6	-1.0
Heart disease (siblings)	0.6	0.8	2.9	1.7	0.3	0.1	1.3	0.1	0.0
Alcohol drinker status: Previous	1.0	1.2	4.2	0.4	0.5	0.5	2.1	-1.1	-1.0
Pack years of smoking	0.4	0.6	1.6	1.3	-0.5	-0.5	0.3	0.9	-0.8
Impedance of whole body	0.3	1.3	2.6	0.6	0.5	1.6	-1.3	-1.6	0.5
Leg fat mass (left)	0.1	0.5	1.5	1.2	0.4	0.8	0.3	0.3	0.6
Arm predicted mass (left)	0.5	2.4	6.3	-1.3	-0.7	-1.1	-2.5	2.2	-0.5