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chr16:86,671-1,488,646

Best TWAS P=1.5e-11 · Best GWAS P=2.73e-11 conditioned to 0.177

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
55	GTEx	Nerve Tibial	WDR24	0.13	0.07	lasso	6	0.09	8.2e-07	-6.6	-6.7	1.5e-11	0.90	0.00	1.00	TRUE
14	GTEx	Artery Aorta	WDR24	0.13	0.09	lasso	3	0.05	9.1e-04	-6.7	-6.7	2.4e-11	0.94	0.00	0.99	FALSE
53	GTEx	Muscle Skeletal	C16orf13	0.05	0.02	lasso	6	0.02	3.5e-03	-6.7	-6.7	2.9e-11	0.95	0.01	0.98	FALSE
58	GTEx	Nerve Tibial	LA16c-313D11.12	0.10	0.03	lasso	6	0.03	2.6e-03	-6.6	-6.6	3.0e-11	0.95	0.01	0.99	FALSE
8	GTEx	Adipose Visceral Omentum	WDR24	0.12	0.09	lasso	2	0.07	1.0e-04	-6.7	-6.6	3.3e-11	0.94	0.00	0.98	FALSE
33	GTEx	Colon Sigmoid	C16orf13	0.20	0.20	lasso	4	0.15	6.4e-06	-6.6	-6.6	3.8e-11	0.94	0.00	0.99	FALSE
7	GTEx	Adipose Subcutaneous	LA16c-313D11.12	0.09	0.04	lasso	4	0.02	1.1e-02	-6.6	-6.6	3.9e-11	0.94	0.01	0.99	FALSE
20	GTEx	Artery Tibial	WDR90	0.11	0.09	enet	6	0.10	1.8e-08	-6.6	-6.6	4.3e-11	0.94	0.00	1.00	FALSE
42	GTEx	Esophagus Mucosa	C16orf13	0.11	0.07	lasso	5	0.07	1.2e-05	-6.6	-6.6	5.2e-11	0.92	0.01	0.99	FALSE
74	GTEx	Thyroid	RHBDL1	0.12	0.10	lasso	11	0.12	2.9e-09	-6.7	-6.6	5.3e-11	0.93	0.00	1.00	FALSE
76	GTEx	Thyroid	FBXL16	0.12	0.09	lasso	8	0.08	2.1e-06	-6.6	6.5	7.5e-11	-0.94	0.01	0.99	FALSE
86	The Cancer Genome Atlas	Breast Invasive Carcinoma	WDR90	0.01	0.00	lasso	3	0.01	6.6e-03	-6.7	6.5	8.2e-11	-0.98	0.01	0.83	FALSE
16	GTEx	Artery Aorta	WDR90	0.19	0.15	lasso	4	0.18	3.6e-10	-6.3	-6.4	1.3e-10	0.92	0.02	0.98	FALSE
21	GTEx	Artery Tibial	LA16c-349E10.1	0.11	0.11	lasso	4	0.10	1.7e-08	-6.3	-6.4	1.4e-10	0.91	0.01	0.99	FALSE
26	GTEx	Breast Mammary Tissue	C16orf13	0.35	0.24	lasso	5	0.28	6.5e-15	-6.3	-6.4	1.5e-10	0.92	0.01	0.99	FALSE
10	GTEx	Adipose Visceral Omentum	WDR90	0.18	0.19	enet	5	0.18	9.7e-10	-6.3	-6.4	1.6e-10	0.90	0.05	0.95	FALSE
32	GTEx	Cells Transformed fibroblasts	WDR90	0.19	0.15	lasso	7	0.14	1.4e-10	-6.3	-6.4	1.7e-10	0.87	0.02	0.98	FALSE
43	GTEx	Esophagus Muscularis	C16orf13	0.23	0.24	lasso	4	0.22	2.8e-13	-6.1	-6.4	1.7e-10	0.90	0.03	0.97	FALSE
3	GTEx	Adipose Subcutaneous	WDR24	0.08	0.06	lasso	2	0.08	9.0e-07	-5.6	-6.3	2.2e-10	0.90	0.02	0.98	FALSE
73	GTEx	Testis	RHOT2	0.24	0.30	lasso	2	0.29	3.4e-13	-6.3	-6.3	2.6e-10	0.89	0.04	0.96	FALSE
49	GTEx	Heart Left Ventricle	C16orf13	0.10	0.08	lasso	3	0.09	1.6e-05	-6.1	-6.3	2.7e-10	0.90	0.02	0.97	FALSE
72	GTEx	Testis	RHBDL1	0.25	0.19	lasso	4	0.17	3.5e-08	-6.3	-6.3	3.2e-10	0.89	0.03	0.97	FALSE
90	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C16orf13	0.04	0.06	blup	47	0.07	5.9e-08	-6.1	-6.3	3.5e-10	0.88	0.01	0.99	FALSE
17	GTEx	Artery Aorta	LA16c-349E10.1	0.20	0.13	lasso	10	0.13	1.8e-07	-6.3	-6.2	4.1e-10	0.88	0.04	0.96	FALSE
27	GTEx	Breast Mammary Tissue (Male)	C16orf13	0.26	0.20	lasso	3	0.15	2.1e-04	-6.1	-6.2	4.2e-10	0.88	0.02	0.88	FALSE
9	GTEx	Adipose Visceral Omentum	C16orf13	0.22	0.18	lasso	9	0.16	6.8e-09	-6.3	-6.2	4.5e-10	0.91	0.02	0.98	FALSE
101	The Cancer Genome Atlas	Thyroid Carcinoma	C16orf13	0.03	0.02	blup	46	0.02	4.7e-03	-6.1	-6.2	4.8e-10	0.84	0.01	0.69	FALSE
30	GTEx	Cells EBV-transformed lymphocytes	WFIKKN1	0.64	0.05	lasso	12	0.01	1.1e-01	-5.1	-6.2	5.1e-10	0.78	0.01	0.93	FALSE
40	GTEx	Esophagus Gastroesophageal Junction	C16orf13	0.33	0.19	lasso	4	0.14	8.5e-06	-6.3	-6.2	5.4e-10	0.90	0.02	0.98	FALSE
67	GTEx	Skin Sun Exposed Lower leg	RHBDL1	0.12	0.05	lasso	8	0.04	2.5e-04	-6.6	-6.2	5.6e-10	0.91	0.01	0.99	FALSE
37	GTEx	Colon Transverse	C16orf13	0.18	0.16	lasso	5	0.16	5.0e-08	-6.1	-6.1	8.6e-10	0.85	0.01	0.99	FALSE
11	GTEx	Adrenal Gland	C16orf13	0.20	0.17	lasso	3	0.13	2.0e-05	-5.6	-6.1	1.0e-09	0.88	0.07	0.81	FALSE
71	GTEx	Stomach	C16orf13	0.15	0.12	lasso	1	0.11	8.7e-06	-6.1	-6.1	1.1e-09	0.86	0.02	0.95	FALSE
84	The Cancer Genome Atlas	Breast Invasive Carcinoma	C16orf13	0.02	0.03	lasso	1	0.02	1.3e-05	-6.1	-6.1	1.1e-09	0.86	0.01	0.99	FALSE
88	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	WFIKKN1	0.18	0.19	lasso	5	0.18	2.8e-09	-6.1	-6.1	1.4e-09	0.86	0.00	1.00	FALSE
19	GTEx	Artery Tibial	C16orf13	0.22	0.16	enet	23	0.19	1.0e-14	-6.7	-6.0	1.6e-09	0.87	0.00	1.00	FALSE
47	GTEx	Heart Atrial Appendage	WDR90	0.13	0.10	lasso	3	0.11	1.7e-05	-5.1	-6.0	1.9e-09	0.83	0.06	0.92	FALSE
12	GTEx	Artery Aorta	RHBDL1	0.14	0.07	enet	13	0.11	1.4e-06	-5.0	-6.0	2.2e-09	0.88	0.02	0.98	FALSE
34	GTEx	Colon Sigmoid	WDR90	0.27	0.17	lasso	5	0.14	1.2e-05	-6.3	-6.0	2.6e-09	0.88	0.02	0.98	FALSE
36	GTEx	Colon Sigmoid	LA16c-349E10.1	0.18	0.19	lasso	5	0.18	8.3e-07	-6.3	-6.0	2.7e-09	0.87	0.01	0.98	FALSE
94	The Cancer Genome Atlas	Lung Adenocarcinoma	C16orf13	0.04	0.03	blup	47	0.04	3.7e-05	-5.2	-5.9	2.9e-09	0.78	0.08	0.86	FALSE
98	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	WFIKKN1	0.16	0.13	blup	48	0.16	7.3e-07	-5.1	-5.9	3.6e-09	0.79	0.04	0.96	FALSE
38	GTEx	Colon Transverse	WDR90	0.26	0.12	lasso	4	0.20	4.5e-10	-6.7	-5.8	5.2e-09	0.79	0.00	1.00	FALSE
15	GTEx	Artery Aorta	C16orf13	0.30	0.20	enet	41	0.22	1.5e-12	-6.7	-5.8	5.9e-09	0.79	0.00	1.00	FALSE
99	The Cancer Genome Atlas	Prostate Adenocarcinoma	JMJD8	0.04	0.03	blup	50	0.03	5.0e-04	-3.3	5.8	6.2e-09	-0.88	0.04	0.79	FALSE
80	METSIM	Adipose	STUB1	0.04	0.04	lasso	3	0.03	1.9e-05	-6.5	-5.8	8.5e-09	0.93	0.02	0.98	FALSE
81	METSIM	Adipose	WDR24	0.04	0.03	enet	17	0.02	1.2e-04	-6.7	-5.7	9.6e-09	0.85	0.01	0.99	FALSE
59	GTEx	Ovary	RHBDL1	0.27	0.02	enet	5	0.04	3.3e-02	-6.1	-5.7	9.8e-09	0.85	0.04	0.58	FALSE
46	GTEx	Heart Atrial Appendage	C16orf13	0.23	0.21	lasso	3	0.17	6.0e-08	-6.3	-5.7	1.2e-08	0.85	0.03	0.97	FALSE
78	GTEx	Whole Blood	RHBDL1	0.10	0.06	lasso	4	0.05	3.6e-05	-5.2	-5.7	1.3e-08	0.80	0.16	0.82	FALSE
48	GTEx	Heart Left Ventricle	WFIKKN1	0.32	0.15	lasso	6	0.15	2.9e-08	-5.1	-5.7	1.5e-08	0.82	0.48	0.52	FALSE
51	GTEx	Muscle Skeletal	RHBDL1	0.09	0.00	lasso	7	0.00	3.2e-01	-5.1	-5.7	1.5e-08	0.79	0.34	0.26	FALSE
97	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	WDR24	0.06	0.05	blup	52	0.06	5.7e-05	-6.3	-5.6	1.7e-08	0.88	0.03	0.93	FALSE
69	GTEx	Skin Sun Exposed Lower leg	WDR24	0.08	0.01	enet	7	0.04	2.5e-04	-5.6	-5.6	2.1e-08	0.77	0.01	0.95	FALSE
5	GTEx	Adipose Subcutaneous	WDR90	0.16	0.11	lasso	4	0.12	3.7e-10	-6.1	-5.6	2.2e-08	0.81	0.05	0.95	FALSE
29	GTEx	Cells EBV-transformed lymphocytes	RHBDL1	0.47	0.12	lasso	11	0.18	2.3e-06	-6.3	-5.6	2.3e-08	0.84	0.07	0.90	FALSE
22	GTEx	Brain Cerebellar Hemisphere	LA16c-349E10.1	0.34	0.13	lasso	10	0.21	4.7e-06	-5.0	5.6	2.4e-08	-0.80	0.18	0.59	FALSE
28	GTEx	Breast Mammary Tissue (Female)	C16orf13	0.47	0.09	lasso	8	0.10	5.6e-04	-6.3	-5.6	2.4e-08	0.82	0.01	0.94	FALSE
24	GTEx	Brain Hypothalamus	WFIKKN1	0.27	0.20	enet	32	0.24	2.6e-06	-5.1	-5.6	2.7e-08	0.79	0.06	0.88	FALSE
79	GTEx	Whole Blood	WDR24	0.10	0.04	enet	15	0.02	9.5e-03	-6.6	-5.6	2.9e-08	0.86	0.01	0.99	FALSE
82	YFS	Blood	WFIKKN1	0.04	0.05	lasso	4	0.05	5.6e-15	-5.1	-5.5	3.5e-08	0.79	0.92	0.08	FALSE
65	GTEx	Prostate	WFIKKN1	0.41	0.22	lasso	6	0.16	8.5e-05	-5.1	-5.5	3.6e-08	0.83	0.03	0.96	FALSE
66	GTEx	Skin Not Sun Exposed Suprapubic	WDR90	0.26	0.03	lasso	9	0.05	9.5e-04	-6.3	-5.5	3.8e-08	0.81	0.01	0.96	FALSE
100	The Cancer Genome Atlas	Prostate Adenocarcinoma	WFIKKN1	0.20	0.39	lasso	4	0.38	1.8e-42	-5.1	-5.5	4.0e-08	0.79	0.66	0.34	FALSE
68	GTEx	Skin Sun Exposed Lower leg	WFIKKN1	0.33	0.42	enet	19	0.44	1.4e-39	-5.1	-5.5	4.6e-08	0.76	0.98	0.02	FALSE
85	The Cancer Genome Atlas	Breast Invasive Carcinoma	RHOT2	0.01	0.01	blup	51	0.01	1.5e-02	-5.3	5.5	4.6e-08	-0.82	0.07	0.58	FALSE
39	GTEx	Esophagus Gastroesophageal Junction	WFIKKN1	0.41	0.34	lasso	6	0.33	1.4e-12	-5.1	-5.5	4.9e-08	0.79	0.50	0.50	FALSE
45	GTEx	Heart Atrial Appendage	WFIKKN1	0.25	0.21	lasso	3	0.16	7.0e-08	-5.1	-5.4	5.7e-08	0.79	0.34	0.66	FALSE
95	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	WFIKKN1	0.12	0.17	lasso	5	0.17	1.2e-18	-5.1	-5.4	6.3e-08	0.78	0.70	0.30	FALSE
93	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	WFIKKN1	0.12	0.13	blup	48	0.13	9.8e-07	-5.1	-5.4	7.2e-08	0.83	0.08	0.92	FALSE
4	GTEx	Adipose Subcutaneous	C16orf13	0.29	0.28	enet	25	0.33	6.0e-28	-6.1	-5.4	7.7e-08	0.83	0.09	0.91	FALSE
54	GTEx	Nerve Tibial	RHBDL1	0.18	0.09	lasso	9	0.13	1.4e-09	-5.3	-5.4	8.4e-08	0.83	0.11	0.89	FALSE
61	GTEx	Ovary	C16orf13	0.44	0.15	lasso	5	0.23	2.7e-06	-6.1	-5.4	8.7e-08	0.84	0.03	0.96	FALSE
35	GTEx	Colon Sigmoid	RAB40C	0.36	0.22	lasso	9	0.21	6.9e-08	-5.3	-5.3	9.5e-08	0.64	0.83	0.11	FALSE
63	GTEx	Pancreas	WFIKKN1	0.37	0.28	enet	18	0.27	7.7e-12	-5.1	-5.3	9.6e-08	0.75	0.96	0.04	FALSE
1	GTEx	Adipose Subcutaneous	RHBDL1	0.11	0.05	lasso	4	0.08	3.6e-07	-5.1	-5.3	1.1e-07	0.83	0.03	0.97	FALSE
62	GTEx	Ovary	RAB40C	0.32	0.27	lasso	3	0.25	6.5e-07	-5.3	-5.3	1.1e-07	0.75	0.26	0.62	FALSE
96	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	STUB1	0.04	0.04	blup	47	0.04	1.8e-03	-5.9	-5.3	1.1e-07	0.87	0.05	0.66	FALSE
91	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	WFIKKN1	0.17	0.18	enet	8	0.18	4.8e-20	-5.1	-5.3	1.2e-07	0.75	0.84	0.16	FALSE
60	GTEx	Ovary	WFIKKN1	0.59	0.60	lasso	2	0.61	8.8e-19	-5.2	-5.3	1.3e-07	0.73	0.96	0.04	FALSE
6	GTEx	Adipose Subcutaneous	RAB40C	0.17	0.10	lasso	4	0.11	4.1e-09	-5.1	-5.3	1.4e-07	0.71	0.97	0.03	FALSE
50	GTEx	Liver	WFIKKN1	0.21	0.17	lasso	3	0.16	3.3e-05	-5.1	-5.3	1.4e-07	0.73	0.28	0.58	FALSE
23	GTEx	Brain Hypothalamus	NARFL	0.23	0.12	lasso	4	0.12	1.1e-03	-6.1	-5.3	1.5e-07	0.84	0.03	0.72	FALSE
77	GTEx	Thyroid	RAB40C	0.28	0.15	enet	27	0.20	4.4e-15	-5.1	-5.2	1.5e-07	0.63	0.98	0.02	FALSE
75	GTEx	Thyroid	WFIKKN1	0.30	0.28	enet	31	0.28	1.1e-21	-5.1	-5.2	1.6e-07	0.71	0.98	0.02	FALSE
89	The Cancer Genome Atlas	Colon Adenocarcinoma	WFIKKN1	0.32	0.25	lasso	11	0.25	1.6e-14	-5.1	-5.2	1.6e-07	0.71	0.84	0.16	FALSE
57	GTEx	Nerve Tibial	RAB40C	0.30	0.21	enet	15	0.24	3.5e-17	-5.1	-5.2	1.7e-07	0.70	0.98	0.02	FALSE
70	GTEx	Spleen	WFIKKN1	0.53	0.29	lasso	5	0.32	5.0e-09	-5.1	-5.2	1.7e-07	0.80	0.36	0.62	FALSE
56	GTEx	Nerve Tibial	WDR90	0.28	0.18	lasso	8	0.23	2.2e-16	-6.3	-5.2	1.9e-07	0.80	0.03	0.97	FALSE
25	GTEx	Brain Putamen basal ganglia	WFIKKN1	0.30	0.38	lasso	4	0.36	1.9e-09	-5.1	-5.2	2.0e-07	0.77	0.78	0.12	FALSE
102	The Cancer Genome Atlas	Thyroid Carcinoma	WFIKKN1	0.38	0.35	lasso	6	0.36	2.9e-36	-5.1	-5.2	2.0e-07	0.72	0.83	0.17	FALSE
18	GTEx	Artery Coronary	C16orf13	0.24	0.15	lasso	4	0.11	1.7e-04	-6.1	-5.2	2.2e-07	0.82	0.02	0.91	FALSE
31	GTEx	Cells Transformed fibroblasts	C16orf13	0.31	0.23	enet	34	0.23	2.8e-17	-6.6	-5.2	2.2e-07	0.86	0.00	1.00	FALSE
41	GTEx	Esophagus Mucosa	WFIKKN1	0.29	0.22	enet	5	0.20	2.9e-13	-5.1	-5.2	2.3e-07	0.75	0.98	0.02	FALSE
52	GTEx	Muscle Skeletal	WFIKKN1	0.12	0.09	lasso	2	0.08	3.5e-08	-5.1	-5.2	2.4e-07	0.73	0.94	0.05	FALSE
2	GTEx	Adipose Subcutaneous	WFIKKN1	0.41	0.32	lasso	8	0.27	2.0e-22	-5.1	-5.1	2.6e-07	0.73	0.98	0.02	FALSE
83	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	WFIKKN1	0.09	0.11	lasso	3	0.11	3.0e-09	-5.1	-5.1	2.8e-07	0.73	0.73	0.27	FALSE
87	The Cancer Genome Atlas	Breast Invasive Carcinoma	WFIKKN1	0.15	0.20	lasso	3	0.20	6.4e-41	-5.1	-5.1	2.8e-07	0.75	0.85	0.15	FALSE
44	GTEx	Esophagus Muscularis	LA16c-349E10.1	0.24	0.07	lasso	6	0.10	2.2e-06	-6.3	-5.1	2.9e-07	0.73	0.04	0.93	FALSE
92	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	WFIKKN1	0.06	0.07	lasso	4	0.07	3.3e-08	-5.1	-5.1	2.9e-07	0.73	0.38	0.62	FALSE
13	GTEx	Artery Aorta	WFIKKN1	0.46	0.37	lasso	3	0.40	1.6e-23	-5.1	-5.1	3.0e-07	0.74	0.98	0.02	FALSE
64	GTEx	Pituitary	WFIKKN1	0.69	0.50	lasso	6	0.45	1.1e-12	-5.1	-5.1	3.0e-07	0.74	0.97	0.03	FALSE