[Hub]/) : Traits : Waist Hip Ratio (WHR) :

chr2:65,961,112-69,314,667

Best TWAS P=4.61e-13 · Best GWAS P=1.36e-22 conditioned to 4.97e-20

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ETAA1 0.15 0.13 enet 34 0.16 6.2e-19 4.6 6.2 7.4e-10 0.03 1.00 0.00 TRUE
2 CommonMind Brain Pre-frontal Cortex MEIS1 0.21 0.11 bslmm 539 0.12 5.5e-15 4.8 6.6 4.0e-11 0.24 1.00 0.00 TRUE
3 GTEx Cells Transformed fibroblasts ETAA1 0.20 0.21 lasso 5 0.20 5.2e-15 6.3 6.6 5.3e-11 0.04 1.00 0.00 TRUE
4 GTEx Muscle Skeletal ETAA1 0.08 0.04 lasso 1 0.01 1.7e-02 6.3 6.3 2.3e-10 0.04 0.28 0.03 FALSE
5 GTEx Nerve Tibial ETAA1 0.18 0.01 enet 43 0.04 9.0e-04 -1.9 7.2 4.6e-13 -0.01 0.24 0.11 TRUE
6 METSIM Adipose ETAA1 0.09 0.05 enet 35 0.06 4.6e-09 3.4 6.3 3.4e-10 0.01 0.98 0.00 TRUE
7 NTR Blood CNRIP1 0.04 0.03 lasso 4 0.04 4.7e-12 -3.7 -5.2 2.1e-07 0.03 0.30 0.70 FALSE
8 ROSMAP Brain Pre-frontal Cortex PLEK 0.11 0.03 lasso 4 0.07 1.5e-09 2.9 -5.9 4.3e-09 0.00 0.39 0.60 FALSE
9 YFS Blood MEIS1 0.05 0.00 blup 535 0.03 4.0e-09 9.8 -6.1 1.1e-09 -0.55 0.01 0.95 TRUE
10 YFS Blood PPP3R1 0.24 0.32 enet 44 0.34 9.1e-116 6.0 -5.4 7.7e-08 0.04 1.00 0.00 FALSE
11 YFS Blood WDR92 0.05 0.05 lasso 14 0.04 1.5e-13 6.3 6.4 1.8e-10 -0.03 1.00 0.00 TRUE
12 The Cancer Genome Atlas Breast Invasive Carcinoma ETAA1 0.05 0.02 blup 42 0.03 1.4e-07 6.6 5.2 1.9e-07 0.01 0.01 0.99 FALSE
13 The Cancer Genome Atlas Esophageal Carcinoma PNO1 0.08 0.07 enet 4 0.08 2.0e-03 6.0 6.0 1.7e-09 -0.03 0.02 0.78 FALSE
14 The Cancer Genome Atlas Glioblastoma Multiforme ETAA1 0.17 0.00 blup 42 0.05 1.5e-02 6.3 5.6 2.2e-08 0.03 0.01 0.60 FALSE
15 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ETAA1 0.16 0.06 enet 10 0.13 1.9e-14 -2.0 5.9 3.4e-09 0.04 0.01 0.99 FALSE
16 The Cancer Genome Atlas Brain Lower Grade Glioma MEIS1 0.04 0.04 enet 8 0.04 6.9e-06 4.8 6.1 1.2e-09 -0.04 0.02 0.98 FALSE
17 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ETAA1 0.05 0.01 blup 42 0.02 1.4e-03 6.3 5.2 1.5e-07 0.03 0.01 0.87 TRUE
18 The Cancer Genome Atlas Prostate Adenocarcinoma ETAA1 0.11 0.10 blup 42 0.12 5.8e-13 6.6 6.0 2.3e-09 0.03 0.00 1.00 FALSE
19 The Cancer Genome Atlas Stomach Adenocarcinoma ETAA1 0.08 0.01 blup 42 0.04 5.8e-04 6.3 6.2 5.2e-10 0.02 0.02 0.88 FALSE
20 The Cancer Genome Atlas Thyroid Carcinoma ETAA1 0.07 0.06 blup 42 0.07 1.1e-07 6.5 6.5 6.0e-11 0.03 0.01 0.99 TRUE
21 The Cancer Genome Atlas Thyroid Carcinoma PNO1 0.04 0.03 blup 41 0.04 1.1e-04 -3.7 -5.2 2.0e-07 0.04 0.02 0.94 FALSE