Best TWAS P=4.61e-13 · Best GWAS P=1.36e-22 conditioned to 4.97e-20
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ETAA1 | 0.15 | 0.13 | enet | 34 | 0.16 | 6.2e-19 | 4.6 | 6.2 | 7.4e-10 | 0.03 | 1.00 | 0.00 | TRUE |
2 | CommonMind | Brain Pre-frontal Cortex | MEIS1 | 0.21 | 0.11 | bslmm | 539 | 0.12 | 5.5e-15 | 4.8 | 6.6 | 4.0e-11 | 0.24 | 1.00 | 0.00 | TRUE |
3 | GTEx | Cells Transformed fibroblasts | ETAA1 | 0.20 | 0.21 | lasso | 5 | 0.20 | 5.2e-15 | 6.3 | 6.6 | 5.3e-11 | 0.04 | 1.00 | 0.00 | TRUE |
4 | GTEx | Muscle Skeletal | ETAA1 | 0.08 | 0.04 | lasso | 1 | 0.01 | 1.7e-02 | 6.3 | 6.3 | 2.3e-10 | 0.04 | 0.28 | 0.03 | FALSE |
5 | GTEx | Nerve Tibial | ETAA1 | 0.18 | 0.01 | enet | 43 | 0.04 | 9.0e-04 | -1.9 | 7.2 | 4.6e-13 | -0.01 | 0.24 | 0.11 | TRUE |
6 | METSIM | Adipose | ETAA1 | 0.09 | 0.05 | enet | 35 | 0.06 | 4.6e-09 | 3.4 | 6.3 | 3.4e-10 | 0.01 | 0.98 | 0.00 | TRUE |
7 | NTR | Blood | CNRIP1 | 0.04 | 0.03 | lasso | 4 | 0.04 | 4.7e-12 | -3.7 | -5.2 | 2.1e-07 | 0.03 | 0.30 | 0.70 | FALSE |
8 | ROSMAP | Brain Pre-frontal Cortex | PLEK | 0.11 | 0.03 | lasso | 4 | 0.07 | 1.5e-09 | 2.9 | -5.9 | 4.3e-09 | 0.00 | 0.39 | 0.60 | FALSE |
9 | YFS | Blood | MEIS1 | 0.05 | 0.00 | blup | 535 | 0.03 | 4.0e-09 | 9.8 | -6.1 | 1.1e-09 | -0.55 | 0.01 | 0.95 | TRUE |
10 | YFS | Blood | PPP3R1 | 0.24 | 0.32 | enet | 44 | 0.34 | 9.1e-116 | 6.0 | -5.4 | 7.7e-08 | 0.04 | 1.00 | 0.00 | FALSE |
11 | YFS | Blood | WDR92 | 0.05 | 0.05 | lasso | 14 | 0.04 | 1.5e-13 | 6.3 | 6.4 | 1.8e-10 | -0.03 | 1.00 | 0.00 | TRUE |
12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ETAA1 | 0.05 | 0.02 | blup | 42 | 0.03 | 1.4e-07 | 6.6 | 5.2 | 1.9e-07 | 0.01 | 0.01 | 0.99 | FALSE |
13 | The Cancer Genome Atlas | Esophageal Carcinoma | PNO1 | 0.08 | 0.07 | enet | 4 | 0.08 | 2.0e-03 | 6.0 | 6.0 | 1.7e-09 | -0.03 | 0.02 | 0.78 | FALSE |
14 | The Cancer Genome Atlas | Glioblastoma Multiforme | ETAA1 | 0.17 | 0.00 | blup | 42 | 0.05 | 1.5e-02 | 6.3 | 5.6 | 2.2e-08 | 0.03 | 0.01 | 0.60 | FALSE |
15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ETAA1 | 0.16 | 0.06 | enet | 10 | 0.13 | 1.9e-14 | -2.0 | 5.9 | 3.4e-09 | 0.04 | 0.01 | 0.99 | FALSE |
16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MEIS1 | 0.04 | 0.04 | enet | 8 | 0.04 | 6.9e-06 | 4.8 | 6.1 | 1.2e-09 | -0.04 | 0.02 | 0.98 | FALSE |
17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ETAA1 | 0.05 | 0.01 | blup | 42 | 0.02 | 1.4e-03 | 6.3 | 5.2 | 1.5e-07 | 0.03 | 0.01 | 0.87 | TRUE |
18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ETAA1 | 0.11 | 0.10 | blup | 42 | 0.12 | 5.8e-13 | 6.6 | 6.0 | 2.3e-09 | 0.03 | 0.00 | 1.00 | FALSE |
19 | The Cancer Genome Atlas | Stomach Adenocarcinoma | ETAA1 | 0.08 | 0.01 | blup | 42 | 0.04 | 5.8e-04 | 6.3 | 6.2 | 5.2e-10 | 0.02 | 0.02 | 0.88 | FALSE |
20 | The Cancer Genome Atlas | Thyroid Carcinoma | ETAA1 | 0.07 | 0.06 | blup | 42 | 0.07 | 1.1e-07 | 6.5 | 6.5 | 6.0e-11 | 0.03 | 0.01 | 0.99 | TRUE |
21 | The Cancer Genome Atlas | Thyroid Carcinoma | PNO1 | 0.04 | 0.03 | blup | 41 | 0.04 | 1.1e-04 | -3.7 | -5.2 | 2.0e-07 | 0.04 | 0.02 | 0.94 | FALSE |