Hub : Genes

PLEK

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.3550	0.1110	2.6e-03	0.036	NA	0.064	NA	0.062	3.2e-02	NA	6.6e-03	NA	7.4e-03
2	NTR	Blood	0.1445	0.0225	0.0e+00	0.173	0.159	0.186	0.183	0.184	1.6e-53	7.0e-49	1.1e-57	1.0e-56	4.0e-57
3	ROSMAP	Brain Pre-frontal Cortex	0.1125	0.0305	4.0e-06	0.026	0.048	0.066	0.050	0.072	2.5e-04	8.4e-07	6.3e-09	4.6e-07	1.5e-09
4	YFS	Blood	0.0805	0.0163	0.0e+00	0.096	0.087	0.110	0.108	0.112	1.1e-29	6.9e-27	4.5e-34	2.3e-33	1.6e-34
5	TCGA	Breast Invasive Carcinoma	0.0222	0.0127	1.0e-03	0.002	0.010	0.012	NA	0.006	1.1e-01	2.8e-03	1.4e-03	NA	2.1e-02
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0293	0.0169	3.2e-03	0.030	0.020	0.006	NA	0.020	2.1e-04	2.1e-03	6.2e-02	NA	2.0e-03
7	TCGA	Prostate Adenocarcinoma	0.0234	0.0139	7.3e-03	0.020	0.024	0.012	NA	0.014	3.2e-03	1.4e-03	1.8e-02	NA	1.2e-02
8	TCGA	Soft Tissue Sarcoma	0.1200	0.0860	4.8e-03	0.027	0.025	0.019	NA	0.029	9.0e-03	1.2e-02	2.6e-02	NA	7.3e-03
9	TCGA	Testicular Germ Cell Tumors	0.1600	0.0900	9.8e-03	-0.003	0.024	-0.007	NA	-0.007	4.2e-01	4.6e-02	7.2e-01	NA	6.8e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	1.0	1.6	4.9	-1.3	-0.3	-2.2	1.1	-1.2	-0.4	-0.1	1.9	-1.2
Bipolar Disorder or Schizophrenia	0.5	1.2	3.8	-1.3	-0.9	-0.9	0.9	-1.2	-1.0	-0.6	1.9	-0.7
Depressed Affect (Nagel 2018)	0.1	0.2	0.7	-0.0	-0.4	0.4	-0.8	-0.6	-0.3	-0.2	0.0	0.4
Depression (Nagel 2018)	0.3	0.5	1.5	-0.8	-0.5	-1.2	0.5	-0.7	-0.5	0.5	0.9	-0.1
Intelligence (Savage-Jansen 2018)	0.3	0.9	3.9	-2.0	0.1	-0.8	1.1	0.3	-0.0	0.7	1.4	0.0
Neuroticism (Nagel 2018)	0.3	0.7	2.5	1.4	-0.5	1.6	-0.7	-0.3	-0.4	-0.5	-0.4	0.8
Schizophrenia (2018)	0.2	0.5	0.9	-0.9	-0.9	0.6	0.3	-0.5	-0.9	-0.7	1.0	0.0
Schizophrenia vs Biploar Disorder	0.6	0.8	3.8	0.2	-0.3	1.9	-0.1	1.1	-0.2	-0.1	-0.8	1.3
Worry (Nagel 2018)	0.4	0.9	4.3	2.1	-0.2	1.6	-0.4	0.2	-0.2	-0.3	-0.6	0.6
Alzheimer’s Disease (in mother)	2.1	2.5	5.4	-2.2	-1.0	-1.4	1.7	-1.7	-1.1	-0.2	2.3	-1.4
Alzheimer’s Disease (in father)	0.8	0.9	2.5	0.3	1.6	-0.5	0.7	-0.4	1.4	1.4	0.0	0.4
Alzheimer’s Disease (including proxy)	1.1	1.6	3.7	-1.0	-0.2	-1.9	0.8	-1.9	-0.4	0.2	1.7	-1.4
Crohns Disease (2017)	0.8	1.7	4.9	-0.8	-0.3	-1.4	1.0	-1.1	-0.3	-0.4	2.2	-2.2
Irritable Bowel Disease (IBD)	0.5	1.2	3.5	-0.1	0.9	-1.0	1.2	0.2	0.7	0.5	1.7	-1.9
Ulcerative Colitis (UC)	0.8	1.5	3.8	0.7	1.9	0.4	0.6	1.8	1.7	1.6	0.0	-0.2
Major Depression (MDD)	1.7	2.1	5.0	-1.7	-1.6	-0.3	-0.8	-2.2	-1.7	-1.7	0.2	-1.3
Reaction Time	0.6	1.1	3.4	-1.3	-1.1	0.0	-1.4	0.3	-1.0	-1.8	-0.6	-0.7
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.5	-1.5	0.7	0.3	0.4	1.6	0.6	1.1	0.1	1.1
Breast Cancer	0.4	0.9	3.3	1.8	-0.4	-0.1	-0.3	-1.6	-0.4	-0.3	0.6	-1.3
Ovarian Cancer	0.2	0.3	0.7	0.7	-0.5	-0.7	0.9	-0.5	-0.5	-0.2	0.4	0.1
Prostate Cancer	1.5	2.1	7.5	-0.8	0.9	-1.4	2.7	0.2	0.8	1.2	2.4	-0.6
Age at First Birth	0.1	0.2	0.6	-0.5	-0.2	0.2	0.2	-0.6	-0.2	0.1	-0.8	-0.1
Bipolar Disorder (2011)	1.1	1.0	3.2	-0.9	-0.9	-1.8	-0.4	-1.1	-1.2	-0.6	0.7	-0.8
Body Mass Index (BMI) (2010)	0.2	0.2	0.6	-0.1	0.7	0.4	-0.1	0.4	0.6	0.3	-0.5	0.8
Coronary Artery Disease (CAD)	0.7	0.8	2.1	0.6	-1.1	0.6	-0.2	-1.5	-1.2	-1.1	0.8	-0.2
Crohns Disease (2012)	1.0	1.6	3.9	-1.7	0.0	-1.3	2.0	-0.3	0.2	-0.1	1.6	-1.8
Mean Putamen Volume	0.6	0.7	1.7	-0.4	-0.8	-1.1	-0.9	-0.6	-0.7	-1.0	0.4	-1.3
Fasting Glucose	1.5	1.8	4.8	-1.4	-1.2	-1.0	0.4	-2.2	-1.4	-1.2	1.2	-1.4
HbA1C	0.7	0.8	2.1	0.3	-1.1	-0.3	0.8	-0.0	-1.2	-0.4	1.4	-1.3
HDL Cholesterol	1.0	1.6	3.2	-1.4	-1.4	-0.8	1.7	-0.6	-1.3	-0.1	1.8	-1.4
LDL Cholesterol	1.4	2.2	5.1	-1.7	-1.0	-2.0	0.4	-1.7	-0.9	-1.3	1.1	-2.2
Lupus	1.2	1.7	3.5	1.9	1.2	1.6	-1.6	0.5	1.1	-0.0	-1.8	1.0
Neuroticism (2016)	0.4	0.6	1.1	0.8	0.9	0.8	-0.2	0.4	0.9	1.0	-0.8	0.2
Primary Biliary Cirrhosis	0.7	1.0	3.9	-2.0	0.3	0.8	1.6	0.5	0.4	0.6	0.3	0.9
Rheumatoid Arthritis	0.4	0.5	3.7	-1.9	-0.6	0.3	-0.1	0.3	-0.6	0.2	0.4	0.1
Schizophrenia (2014)	0.4	0.8	3.1	-0.8	-0.9	-0.3	0.9	-0.7	-0.9	-0.5	1.8	-0.3
Triglycerides	0.6	0.9	2.5	-0.5	-0.8	-1.6	0.4	-1.1	-0.9	-1.0	0.8	-1.1
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.6	0.1	-0.7	1.2	0.7	0.3	-0.4	-0.2	-0.6	1.3
Ulcerative Colitis	1.0	1.4	3.3	-1.1	1.1	-0.3	1.8	1.8	1.1	1.2	0.7	-0.3
Blood Eosinophil Count	0.3	2.3	12.5	-1.0	0.1	-1.2	3.5	0.4	0.0	0.9	1.6	1.4
Blood Platelet Count	0.5	6.3	15.3	0.2	-3.3	-0.8	-3.9	-2.2	-3.5	-3.5	-0.5	-0.8
Blood Red Count	0.5	5.0	13.2	-1.3	-3.6	0.1	-1.0	-2.7	-3.6	-3.0	-0.2	-0.1
Blood White Count	0.2	1.3	4.4	0.8	0.2	-2.1	1.7	1.5	0.2	0.8	1.0	0.2
Heel T-Score	0.8	6.1	10.1	-1.6	-3.2	-3.0	0.8	-2.4	-2.9	-2.5	2.3	-2.6
BMI	0.8	4.4	11.1	-2.3	-3.3	-0.5	0.1	-1.8	-3.3	-2.6	0.8	-1.2
Height	0.2	3.4	19.3	-2.9	0.2	-4.4	1.3	-0.1	0.2	0.5	0.9	-0.4
Waist Hip Ratio (WHR)	1.7	7.5	34.5	-2.1	-1.5	-5.9	-0.8	-2.4	-1.8	-1.8	1.9	-3.2
Systolic Blood Pressure	1.2	6.1	24.5	5.0	0.4	4.4	-2.1	1.5	0.7	-0.5	-1.7	-0.4
Smoking Status	0.5	1.1	6.6	-0.4	-0.5	-2.6	0.4	-0.4	-0.6	-0.4	1.1	-1.2
Allergy or Eczema	1.0	2.7	4.8	-1.2	-1.9	-0.0	0.3	-1.6	-1.9	-2.1	2.2	-1.9
Cardiovascular Disease	1.1	3.7	8.1	2.0	-2.6	2.7	-1.1	-0.3	-2.4	-2.9	-0.2	-0.6
Hypothyroidism (self reported)	0.6	1.5	3.7	-1.1	0.9	1.9	-1.0	1.2	1.1	0.2	-1.9	0.2
Respiratory disease	0.1	0.2	0.5	-0.7	-0.4	0.4	-0.6	0.5	-0.4	-0.4	0.0	-0.6
Type 2 Diabetes (T2D) (2018)	0.8	1.5	3.1	-0.8	-1.7	-1.6	-0.4	-1.6	-1.8	-1.1	0.4	-0.2
Lung FEV1/FVC ratio	0.3	1.3	3.7	0.6	-1.7	1.9	0.8	-0.3	-1.6	-1.2	0.7	-0.3
Lung FVC	0.4	1.8	7.2	0.1	0.7	0.1	-2.7	1.8	0.8	0.1	-1.9	0.9
Neuroticism	0.3	0.6	1.3	1.1	-0.9	0.6	-1.0	-0.7	-1.0	-0.7	0.1	0.3
Chronotype (morning person)	0.1	0.3	1.0	0.1	0.4	0.5	-0.1	0.7	0.4	0.6	-1.0	0.8
Hair Pigment	0.0	0.3	0.7	0.5	-0.4	0.2	0.2	-0.8	-0.3	-0.6	0.2	-0.8
Tanning	0.0	0.6	1.7	-1.1	-0.2	-0.9	1.1	0.2	-0.3	0.5	1.3	0.0
Hand grip strength (left)	0.7	1.9	5.1	-2.2	-0.5	-2.0	1.4	0.4	-0.5	0.3	1.1	-1.9
Number of treatments/medications taken	0.2	0.4	1.1	1.1	-0.1	-0.2	0.1	-0.6	-0.2	-1.1	0.7	-0.4
Average weekly spirits intake	0.4	0.5	1.6	0.3	0.6	-0.1	-0.9	1.3	0.7	-0.4	0.1	-0.8
Sensitivity / hurt feelings	0.4	0.7	3.9	2.0	0.2	0.8	-0.1	-0.6	0.2	0.1	-0.6	1.0
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.6	0.2	-1.0	-0.7	0.6	-0.5	-1.0	-0.4	1.3	-0.8
Hearing difficulty/problems: Yes	0.5	0.8	4.6	-2.1	-0.2	-0.4	0.7	-0.4	-0.6	0.0	0.6	0.8
Relative age of first facial hair	0.9	1.8	6.9	1.8	0.7	2.6	-1.0	1.4	0.7	0.2	-1.4	-0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.8	-1.0	0.2	-1.1	0.9	0.7	0.2	0.0	1.0	-1.7
Ever used hormone-replacement therapy (HRT)	1.0	1.2	3.2	0.0	-1.2	0.6	-1.4	-1.8	-1.2	-0.9	-1.1	0.9
Ever had hysterectomy (womb removed)	0.7	0.8	2.6	-1.6	-1.3	0.3	-0.5	0.1	-1.3	-1.1	-0.1	-0.2
Systolic blood pressure, automated reading	1.1	3.3	13.0	3.6	0.4	3.1	-1.7	0.2	0.6	-0.2	-1.8	0.7
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	2.1	-0.2	-0.1	-1.4	-0.2	-0.0	0.1	-0.1	0.8	-1.5
Angina	0.9	1.2	5.4	2.3	0.9	1.0	0.5	-0.1	1.1	0.4	-0.7	1.2
Medication for hormone replacement therapy	0.2	0.2	0.8	-0.3	-0.2	0.7	0.7	-0.9	-0.1	0.1	0.0	0.2
Vitamin and mineral supplements	0.6	0.8	2.2	1.1	1.0	-0.3	0.9	0.9	1.0	1.5	-0.3	0.6
Supplements: Zinc	0.3	0.3	0.9	-0.8	0.4	-1.0	0.5	0.9	0.2	0.2	0.3	-0.3
Medication: Co-codamol	0.2	0.2	0.7	-0.1	0.3	-0.3	-0.4	-0.8	0.2	-0.5	-0.8	0.3
Medication: Metformin	0.4	0.5	1.5	-0.4	-0.9	-0.5	-1.2	-0.7	-0.9	-0.0	-0.5	0.7
Diabetes (father)	0.5	0.6	1.7	-0.8	0.2	-1.3	-0.4	0.3	0.4	-0.1	1.0	-1.2
Diabetes (mother)	0.9	1.1	3.0	-0.2	-1.7	-0.2	-0.4	-0.7	-1.7	-1.7	0.5	-0.2
Severe depression (siblings)	1.7	1.9	4.3	1.5	1.2	1.3	-1.0	0.6	1.2	1.2	-1.8	2.1
Pack years adult smoking proportion	3.8	5.8	12.4	-2.2	-1.6	-3.5	1.7	-3.1	-1.7	-1.4	3.1	-2.5
Impedance of leg (right)	0.5	2.3	5.5	2.4	1.6	-0.5	-1.8	0.5	1.8	0.9	-1.6	1.4
Leg fat-free mass (left)	0.8	4.4	20.1	-4.5	-2.2	-1.4	1.9	-0.3	-2.2	-1.2	1.4	-1.0
Trunk fat percentage	0.2	0.8	1.6	-1.0	-0.7	-0.3	-1.0	-1.1	-0.7	-1.2	-0.5	1.2
Hand grip strength (right)	0.6	1.7	5.0	-2.2	-1.1	-1.9	1.4	0.3	-1.1	-0.4	0.8	-1.1
Townsend deprivation index at recruitment	0.3	0.5	1.0	0.9	0.9	0.5	-0.6	0.8	1.0	0.3	-0.1	0.1
Current tobacco smoking	1.3	2.1	9.0	-0.5	0.8	-3.0	1.4	-0.5	0.7	0.6	1.9	-1.6
Average weekly fortified wine intake	0.5	0.6	1.5	1.2	1.1	0.2	0.5	0.5	0.9	0.9	0.3	0.5
Maternal smoking around birth	0.3	0.5	1.6	-0.5	-0.2	1.0	-0.7	0.2	-0.2	-0.2	-0.9	1.2
Fed-up feelings	0.6	1.1	3.0	-0.1	-1.3	0.9	-1.0	-1.7	-1.3	-1.2	0.1	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	3.5	-0.9	-0.7	-1.5	0.2	-1.9	-0.7	-0.8	1.6	-1.0
Relative age voice broke	0.4	0.6	1.7	0.8	-0.2	1.3	-0.1	1.3	-0.2	-0.3	-0.9	-0.5
Taking other prescription medications	0.1	0.2	1.0	1.0	0.2	-0.2	-0.6	-0.3	0.1	-0.6	-0.2	-0.2
Age when periods started (menarche)	0.6	1.5	5.3	2.0	0.7	0.3	-2.3	0.3	0.7	0.3	-1.8	0.3
Bilateral oophorectomy (both ovaries removed)	2.0	2.4	4.9	-1.4	-1.8	0.3	-1.9	-1.7	-1.9	-2.2	0.5	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	6.1	0.2	-2.5	-2.1	-0.3	-1.1	-2.4	-2.3	1.1	-1.3
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.7	0.2	-0.3	-1.4	0.6	-1.6	-0.3	-0.4	0.6	-0.9
Qualifications: CSEs or equivalent	2.9	3.8	8.5	-1.5	-2.0	-1.9	2.1	-2.2	-2.1	-0.8	2.9	-1.6
Serious illness, injury or assault to yourself	0.5	0.6	3.2	-1.2	-0.0	0.0	-1.8	-0.3	-0.3	0.1	-0.5	0.5
High blood pressure	0.7	2.0	5.8	1.6	-1.8	2.4	-0.6	-0.2	-1.7	-1.7	-0.4	-0.1
Hayfever, allergic rhinitis or eczema	1.7	3.7	8.3	-0.5	-2.3	-0.6	0.2	-1.4	-2.1	-2.7	2.4	-2.9
Multivitamins +/- minerals	0.8	1.1	2.0	-1.1	-1.3	0.2	-0.8	-1.4	-1.4	-1.4	0.0	-0.4
Stomach or abdominal pain in last month	0.4	0.5	1.5	-0.6	-0.5	-1.2	0.4	-1.0	-0.6	-0.1	0.7	0.1
Supplements: Glucosamine	0.6	0.7	4.2	-0.1	-0.3	2.0	-1.1	0.2	-0.4	-0.4	-0.8	0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.3	0.3	0.1	-0.4	1.1	0.7	0.2	0.4	0.6	-0.3
Medication: Atenolol	1.5	1.9	3.8	1.4	1.8	0.3	1.1	1.2	1.8	2.0	-0.7	1.2
Medication: Levothyroxine sodium	0.8	1.4	4.1	-0.5	-0.1	2.0	-1.7	0.9	0.0	-0.7	-1.7	1.0
Sitting height	0.3	1.9	9.6	-3.1	-0.5	-2.0	1.7	0.3	-0.5	0.4	-0.3	0.6
Chronic bronchitis/emphysema (father)	0.4	0.5	1.5	0.0	0.1	1.2	-0.5	-0.3	0.0	-0.4	-1.0	1.2
High blood pressure (mother)	2.3	3.3	14.1	1.2	0.7	3.8	0.1	0.9	0.8	1.2	-2.1	2.5
Body mass index (BMI)	0.4	1.8	4.2	-1.9	-2.1	0.1	-0.2	-1.1	-2.0	-1.9	0.0	0.2
Impedance of leg (left)	0.4	2.1	4.0	2.0	1.9	-0.9	-1.2	0.4	2.0	1.1	-1.2	1.4
Leg predicted mass (left)	0.8	4.2	19.5	-4.4	-2.1	-1.4	1.9	-0.3	-2.1	-1.2	1.4	-1.0
Trunk fat mass	0.3	1.3	4.2	-2.0	-1.2	-1.0	-0.2	-1.1	-1.2	-1.4	0.0	0.7
Waist circumference	1.0	3.7	9.7	-3.1	-1.8	-2.7	0.7	-1.8	-1.9	-1.5	1.6	-1.1
Number of incorrect matches in round	1.0	1.7	5.2	-0.7	-0.6	-2.0	0.1	-2.3	-0.7	-1.4	1.1	-1.2
Past tobacco smoking	0.1	0.3	1.5	0.2	-0.1	1.2	0.0	-0.0	-0.1	-0.1	-0.2	0.8
Alcohol usually taken with meals	0.3	0.5	2.7	-0.7	-0.2	0.9	0.5	-0.4	-0.3	0.4	-0.6	1.6
Nervous feelings	0.4	0.7	5.2	2.3	0.5	0.2	-0.2	0.4	0.4	0.2	-0.3	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.1	1.1	0.1	-0.6	-0.4	-0.2	0.1	-0.1	0.6	-1.0
Hearing difficulty/problems with background noise	0.4	0.6	1.6	-0.1	0.7	-0.9	1.3	0.7	0.3	0.7	1.3	-0.1
Hair/balding pattern: Pattern 2	0.5	0.6	1.6	-0.3	-0.7	1.3	-0.9	0.7	-0.7	-0.3	-0.7	1.1
Had menopause	0.8	1.0	3.2	0.8	0.8	1.4	-0.4	-0.4	0.9	0.4	-1.3	1.8
Had other major operations	0.5	0.6	1.4	0.2	1.2	-0.0	0.3	0.3	1.0	0.8	0.7	-1.2
Forced vital capacity (FVC)	0.5	1.8	8.0	-2.5	-0.3	-2.8	0.2	0.8	-0.3	0.2	0.5	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	4.0	0.6	-2.0	-1.4	-0.2	-0.3	-1.9	-1.9	0.3	-0.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.1	-0.3	-1.0	-1.0	0.8	0.2	-0.9	-0.6	1.0	-1.0
Qualifications: None of the above	1.4	2.9	7.2	1.6	-1.8	-0.3	-2.0	-2.1	-1.7	-2.7	-0.2	-1.4
Financial difficulties in last 2 years	1.7	2.3	5.9	-1.7	-1.3	-1.5	0.7	0.4	-1.3	-1.2	2.1	-2.4
Mouth/teeth dental problems	0.7	1.1	2.8	-1.3	0.2	-1.3	1.7	0.1	0.0	1.3	1.3	0.3
Heart attack	1.3	1.6	3.5	0.7	1.7	1.0	-0.4	0.4	1.7	1.2	-1.5	1.9
Allergy	0.7	1.7	4.9	0.5	1.4	0.2	0.4	0.7	1.3	1.9	-1.5	2.2
Pain all over the body in last month	0.5	0.6	2.4	-0.7	-0.2	-0.6	-0.5	-0.6	-0.3	-0.7	0.9	-1.6
Diabetes (self-reported)	0.5	0.8	1.5	-0.9	-1.2	-1.2	-0.6	-1.0	-1.2	-0.5	-0.1	0.5
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.7	-0.2	-0.2	-1.3	0.4	-1.6	0.0	-0.7	1.5	-1.6
Medication: Ramipril	0.6	0.7	1.6	1.1	-0.6	0.9	-0.4	-1.0	-0.4	-0.7	-1.3	0.6
Medication: Simvastatin	0.2	0.2	1.1	-0.1	-0.3	0.6	0.2	0.3	-0.1	-0.0	-0.7	1.1
Fluid intelligence score	1.1	2.4	5.2	-1.1	2.2	0.2	1.1	2.0	2.0	2.3	0.0	1.1
Illnesses of siblings	1.7	2.4	7.6	-2.8	-1.4	-1.8	0.9	-0.6	-1.3	-0.9	1.4	-1.8
Neuroticism score	0.4	0.8	4.2	2.0	-0.6	0.8	-0.7	-0.6	-0.7	-0.5	0.4	-0.4
Weight	0.7	3.3	12.9	-3.6	-2.1	-1.4	1.0	-1.0	-2.1	-1.6	0.8	-0.3
Impedance of arm (right)	0.6	2.9	5.5	1.8	2.3	1.6	0.0	1.4	2.4	1.7	-0.8	1.9
Arm fat percentage (right)	0.2	0.8	1.6	-0.7	-0.8	1.1	-0.7	-0.6	-0.8	-1.2	-0.7	1.2
Trunk fat-free mass	0.8	4.4	17.6	-4.2	-2.2	-1.9	1.4	-0.3	-2.2	-1.4	1.2	-1.6
Hip circumference	0.3	1.2	6.2	-2.5	-1.0	0.2	1.1	-0.5	-1.0	-0.4	0.2	1.0
Time employed in main current job	0.1	0.2	0.7	0.0	-0.4	-0.2	0.6	-0.8	-0.3	0.0	0.3	-0.3
Alcohol intake versus 10 years previously	0.1	0.1	0.4	-0.7	-0.0	-0.4	-0.0	-0.3	-0.0	0.3	0.2	-0.6
Father’s age at death	0.3	0.3	1.2	-0.6	-0.2	-1.1	-0.2	-0.9	-0.4	-0.3	0.7	0.0
Worrier / anxious feelings	1.1	2.1	7.8	2.8	0.2	2.6	-0.3	0.6	0.4	0.1	-1.4	1.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	0.6	0.3	0.6	-0.5	0.5	0.3	0.2	-0.1	0.6
Falls in the last year	0.3	0.4	1.0	0.8	0.7	0.4	-1.0	0.0	0.7	0.1	-0.9	0.1
Hair/balding pattern: Pattern 3	1.1	1.6	4.8	-1.0	-1.4	-0.6	-1.4	-2.2	-1.4	-1.5	-0.2	-0.8
Number of live births	1.2	1.8	6.5	0.8	-0.4	-0.0	-2.5	-1.6	-0.7	-1.9	-0.1	-1.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	5.6	-2.4	-0.8	-1.6	0.4	1.1	-0.8	-0.3	0.5	-0.6
Pulse rate	0.2	0.4	1.1	-0.1	-0.1	-0.9	-1.1	-0.4	-0.2	-0.6	0.5	-1.0
Happiness	0.9	1.1	3.0	-0.2	1.7	-0.9	0.3	-0.9	1.7	1.4	0.6	-0.6
Noisy workplace	0.4	0.4	1.2	-0.2	0.6	-0.5	0.8	1.1	0.7	0.9	0.3	-0.1
Qualifications: A levels/AS levels or equivalent	2.2	4.8	14.7	-1.0	2.5	-0.6	3.8	2.2	2.4	3.0	1.0	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.5	1.0	1.0	0.8	0.1	0.1	0.8	0.9	-0.2	1.6
Mouth/teeth dental problems: Dentures	1.1	1.8	3.8	-0.0	-1.6	1.0	-1.9	-1.3	-1.6	-1.9	-0.9	-0.3
Asthma	0.4	0.7	1.4	-1.2	-0.8	-0.6	-0.6	-0.9	-0.7	-0.8	0.4	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.3	-1.1	-0.4	-0.9	-1.1	-0.7	-0.5	-0.6	0.2	-0.8
Medication: Cholesterol lowering	0.1	0.2	1.2	0.5	-0.1	-0.3	-0.0	-1.1	-0.1	-0.0	-0.1	0.7
Depression (self-reported)	0.6	0.7	2.0	-0.3	0.1	-1.4	0.9	0.7	0.2	-0.1	1.3	-1.2
Medication: Lansoprazole	0.4	0.4	1.3	-0.7	0.7	0.5	-0.2	0.2	0.8	0.3	-0.7	1.2
Prospective memory result	0.3	0.3	1.9	1.4	-0.3	-0.1	-0.4	0.8	-0.1	0.2	-0.5	-0.2
Lung cancer (father)	2.0	2.3	4.9	-1.2	-1.8	0.5	-2.2	-1.7	-1.8	-1.6	-1.3	0.6
Illnesses of mother	0.6	0.7	2.3	-0.2	0.8	-1.5	-0.5	0.3	1.1	0.3	0.1	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.5	-1.6	-1.0	-1.4	0.7	1.0	-0.9	-0.2	0.4	-0.6
Pulse wave Arterial Stiffness index	0.7	0.8	2.0	1.1	1.3	0.0	0.1	0.2	1.2	1.4	0.5	-0.6
Impedance of arm (left)	0.4	1.8	3.5	1.9	1.7	1.2	-0.1	0.8	1.8	1.3	-0.6	1.5
Arm fat mass (right)	0.2	1.0	3.3	-1.8	-1.3	0.1	0.2	-0.5	-1.2	-1.3	-0.2	0.7
Trunk predicted mass	0.8	4.7	17.6	-4.2	-2.4	-1.9	1.5	-0.4	-2.4	-1.5	1.4	-1.6
Standing height	0.3	3.4	13.8	-3.7	-0.4	-2.8	2.3	0.2	-0.5	0.2	1.3	-1.0
Length of working week for main job	0.5	0.5	1.7	-1.0	0.1	-0.4	0.0	1.1	0.0	0.7	-0.2	1.3
Exposure to tobacco smoke at home	1.0	1.1	5.2	0.5	-0.0	-1.5	-0.4	-2.3	-0.2	0.1	1.0	-1.0
Breastfed as a baby	0.3	0.4	1.2	-1.1	0.0	-0.8	0.9	-0.1	-0.0	-0.3	0.2	0.9
Tense / ‘highly strung’	0.3	0.5	1.4	0.8	-0.5	-0.1	-0.2	-0.7	-0.7	-0.8	0.4	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.6	8.3	-1.5	-1.9	-1.5	0.0	-2.9	-1.9	-1.7	2.4	-2.0
Hair/balding pattern: Pattern 4	0.2	0.4	1.2	-1.1	-0.3	-0.6	0.9	0.0	-0.5	-0.1	0.4	0.8
Birth weight of first child	0.8	1.5	3.7	-1.4	1.6	-1.3	0.3	0.9	1.5	1.9	0.1	-0.3
Peak expiratory flow (PEF)	0.5	1.2	4.8	-1.2	-0.3	1.2	1.2	2.2	-0.2	0.5	-0.3	1.1
Pulse wave reflection index	0.1	0.2	0.4	-0.6	-0.2	0.4	0.6	-0.3	-0.1	0.5	0.3	0.1
Ever highly irritable/argumentative for 2 days	1.7	2.0	6.4	-1.0	-0.2	-1.7	1.3	-1.1	-0.3	-0.4	2.5	-2.1
Loud music exposure frequency	1.1	1.2	3.7	-0.8	-0.8	-1.9	-0.3	0.3	-0.7	-1.0	0.9	-1.8
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	5.4	0.6	1.3	1.4	1.9	2.1	1.3	2.3	-0.0	1.6
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.0	1.0	0.6	0.2	0.8	0.9	0.9	-0.0	0.5	-1.0
Blood clot in the leg (DVT)	1.1	1.4	5.3	0.4	1.0	-1.5	-1.6	-0.0	1.0	-0.4	0.8	-2.3
Medication: Paracetamol	0.9	1.5	3.1	-1.1	-1.1	-0.5	1.3	-1.3	-1.0	-1.3	1.7	-1.5
Headache pain in last month	0.6	1.1	4.6	-0.0	0.8	-2.1	-0.3	-1.2	0.7	0.3	1.0	-1.3
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	1.8	-1.3	0.4	-0.4	0.2	0.6	0.4	0.3	0.5	-1.0
Glaucoma (self-reported)	2.6	3.1	6.6	2.3	1.2	2.6	-2.2	0.1	1.3	0.7	-2.4	1.4
Gout (self-reported)	1.0	1.3	3.8	-1.5	-0.4	-1.3	1.5	-0.7	-0.5	-0.0	2.0	-1.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.6	-1.3	0.5	1.6	-1.4	1.0	0.5	-0.1	-1.5	0.1
Medication: Amlodipine	0.6	0.8	2.2	0.8	-0.7	1.5	-1.0	0.4	-0.6	-0.6	-0.9	1.1
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.1	0.0	0.1	0.4	0.5	-0.9	-0.0	0.1	0.3	-1.1
Birth weight	0.4	0.8	3.3	-1.8	-0.1	-1.1	1.2	0.7	-0.2	0.7	0.4	0.1
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.4	-1.0	-1.4	0.7	0.7	-0.2	-1.5	-0.7	0.4	0.2
High blood pressure (siblings)	2.2	3.1	11.5	3.4	1.1	2.5	-1.7	0.7	1.1	0.1	-1.8	1.3
Forced vital capacity (FVC), Best measure	0.4	1.6	7.5	-2.1	-0.5	-2.7	0.3	0.7	-0.5	0.2	0.5	-0.8
Body fat percentage	0.2	0.8	1.5	-0.8	-0.6	-0.2	-1.2	-1.1	-0.6	-1.2	-0.7	1.2
Leg fat percentage (right)	0.3	1.0	2.5	-0.4	-0.5	0.2	-1.6	-0.4	-0.4	-0.9	-1.5	1.6
Arm fat-free mass (right)	1.1	5.6	19.2	-4.4	-2.7	-2.5	1.2	-1.1	-2.6	-1.9	1.3	-1.5
Exposure to tobacco smoke outside home	0.5	0.6	2.7	1.6	-0.8	0.2	0.0	-0.1	-0.8	-0.8	0.7	-0.6
Comparative body size at age 10	0.2	0.6	2.0	0.1	0.8	-0.7	1.4	1.0	0.7	0.7	0.3	0.4
Number of full brothers	0.2	0.3	0.7	-0.4	0.8	-0.6	-0.4	0.3	0.6	0.9	-0.2	0.5
Worry too long after embarrassment	0.5	0.9	3.8	1.9	-0.6	1.4	-0.3	-0.6	-0.8	-0.6	-0.2	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.5	0.5	-0.8	-0.3	-0.5	-1.3	-0.8	-1.1	0.9	-1.6
Wheeze or whistling in the chest in last year	0.3	0.5	1.7	-0.9	-0.2	-1.3	0.2	-0.4	-0.2	-0.6	0.5	-1.1
Number of children fathered	2.4	2.7	5.5	-1.3	-2.3	-1.4	-0.2	-1.1	-2.3	-2.2	1.2	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.2	1.1	0.4	-0.3	-1.5	1.0	0.4	-0.4	-0.5	0.1
Age at first live birth	1.8	3.2	7.4	0.3	2.3	-0.2	2.3	2.2	2.3	2.7	-0.3	1.0
Pulse wave peak to peak time	0.6	0.7	1.9	-1.4	-1.1	-0.3	0.2	-0.1	-1.1	-1.1	-0.4	0.6
Health satisfaction	0.5	0.6	2.6	0.4	-0.2	-0.4	-0.7	-1.1	-0.4	0.0	0.8	-1.6
Shortness of breath walking on level ground	0.9	1.1	3.1	0.6	0.2	-1.4	-0.0	-1.2	-0.0	0.1	1.8	-1.8
Qualifications: College or University degree	0.5	1.7	4.4	-2.1	1.2	-0.9	0.7	1.7	1.1	1.7	-0.4	0.7
Eye problems/disorders: None of the above	0.7	0.8	3.0	0.1	0.9	-1.1	1.7	-0.0	0.8	1.1	0.7	-0.1
Mouth/teeth dental problems: Loose teeth	1.1	1.3	4.0	0.7	-0.6	-1.2	1.2	-1.1	-0.7	-0.5	1.4	-2.0
Emphysema/chronic bronchitis	0.6	0.7	1.9	-1.4	-0.4	1.4	-0.5	0.2	-0.4	-0.7	-0.6	1.0
Medication for pain relief, constipation, heartburn	0.6	1.1	2.7	0.2	1.4	0.5	0.5	1.3	1.4	1.6	-0.4	1.0
Neck or shoulder pain in last month	1.1	1.6	5.0	-0.2	-1.3	-1.2	0.1	-1.1	-1.2	-1.3	1.3	-2.2
Medication: Blood pressure	0.2	0.3	1.3	1.1	-0.4	0.1	0.2	-0.6	-0.5	-0.4	0.2	0.3
Angina (self-reported)	0.8	1.0	5.0	2.2	0.8	0.9	0.4	-0.2	1.1	0.2	-0.5	1.0
Migraine (self-reported)	0.2	0.3	0.6	-0.3	-0.7	0.7	-0.2	-0.7	-0.8	-0.5	-0.2	0.2
Medication: Ibuprofen	0.4	0.5	1.7	-1.0	-0.1	-1.3	-0.3	-0.7	-0.1	-0.3	0.6	-0.8
Medication: Allopurinol	1.1	1.5	4.0	-0.8	-0.6	-2.0	0.7	-1.1	-0.7	-0.6	2.0	-1.2
Medication: Omeprazole	3.4	4.1	12.5	-0.3	-2.1	-0.9	-1.2	-1.4	-2.1	-3.0	1.5	-3.5
Medication: Seretide 50 evohaler	0.4	0.4	1.1	-0.6	-0.9	0.1	0.6	0.6	-0.7	-1.1	0.5	0.2
Mean time to correctly identify matches	0.9	1.6	5.8	-0.4	-1.1	0.8	-2.4	-0.1	-1.0	-2.2	-1.1	-0.5
Heart disease (mother)	0.7	0.8	3.3	0.9	0.2	1.8	-0.9	1.2	0.2	-0.1	-1.0	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.5	1.1	-0.9	0.0	-0.2	-0.8	-0.9	-1.6	0.3	-1.1
Whole body fat mass	0.3	1.2	4.3	-2.1	-1.2	-0.8	-0.2	-0.8	-1.2	-1.3	-0.1	0.6
Leg fat mass (right)	0.3	1.2	4.2	-2.0	-1.3	-0.7	-0.1	-0.6	-1.2	-1.1	-0.5	0.8
Arm predicted mass (right)	1.0	5.2	17.6	-4.2	-2.6	-2.4	1.4	-1.0	-2.6	-1.7	1.4	-1.4
Pulse rate, automated reading	0.7	2.2	6.4	0.8	-1.4	0.0	-2.5	-0.5	-1.5	-2.5	0.2	-1.3
Alcohol intake frequency.	0.4	1.0	1.8	1.1	1.2	0.9	0.5	0.2	1.1	1.3	-0.9	1.1
Comparative height size at age 10	0.2	1.1	6.2	-2.5	-0.3	-0.8	1.2	1.2	-0.2	-0.1	0.2	-0.3
Number of full sisters	0.9	1.1	3.7	0.2	-0.9	-1.0	-0.3	-1.9	-1.1	-1.5	0.4	-0.6
Suffer from ‘nerves’	1.0	1.6	6.9	2.6	-0.5	1.9	-0.8	0.3	-0.4	-0.5	-1.3	0.8
Overall health rating	0.5	1.0	3.8	0.9	-0.3	-0.7	-2.0	-0.7	-0.3	-1.5	-0.4	-0.8
Chest pain or discomfort	0.7	1.1	3.0	-0.1	-1.1	-0.2	-0.6	-0.6	-1.1	-1.6	0.8	-1.7
Had major operations	2.8	3.3	7.7	2.4	0.8	2.8	-1.9	1.5	0.9	-0.2	-2.4	1.7
Age at last live birth	0.5	0.7	2.1	0.7	0.9	0.3	0.3	1.5	0.8	0.8	-1.1	0.4
Family relationship satisfaction	0.8	1.0	2.2	-0.4	1.3	-0.5	0.8	1.4	1.5	1.3	0.4	-0.1
Leg pain on walking	0.9	1.1	3.4	-1.3	-0.3	-0.1	-1.6	-1.8	-0.5	-1.1	0.1	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.3	0.8	-0.5	0.7	-0.5	0.6	-0.4	-0.4	0.5	-1.1
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.9	0.8	0.8	-0.0	-0.7	0.1	0.9	-0.1	-0.7	0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.7	0.1	0.1	0.1	1.3	0.8	0.4	0.2	-0.4	0.5
Medication: Aspirin	1.3	1.7	4.4	1.9	-0.1	1.5	-1.3	0.2	-0.1	-0.3	-1.6	2.1
Supplements: Vitamin C	0.9	1.0	3.8	0.4	0.3	1.3	0.7	1.9	0.3	0.3	-0.4	1.6
Knee pain experienced in last month	0.8	1.2	6.0	0.8	-0.9	0.7	0.3	-2.4	-1.0	-1.2	0.3	0.6
Hypertension (Self-reported)	0.9	2.5	7.0	2.1	-1.9	2.6	-1.0	-0.2	-1.7	-1.8	-0.8	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.8	2.3	0.8	-0.7	-0.1	-1.5	-0.5	-0.6	-1.4	-0.9	0.0
Illnesses of father: Heart disease	1.0	1.4	5.3	1.6	0.4	0.3	2.3	1.0	0.5	0.4	1.4	1.0
Illnesses of siblings: Diabetes	0.9	1.1	2.2	0.9	0.9	1.3	-1.1	-0.1	0.7	0.9	-1.5	1.4
Smoking status: Previous	0.3	0.4	1.6	0.4	0.1	0.1	-0.8	-0.1	0.1	0.0	-1.3	0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	6.2	-2.4	-0.7	-2.5	1.4	-1.2	-0.9	0.2	1.1	-0.3
Whole body fat-free mass	0.9	5.1	21.3	-4.6	-2.3	-2.0	1.8	-0.4	-2.3	-1.4	1.5	-1.5
Leg fat-free mass (right)	0.9	5.1	21.7	-4.7	-2.0	-1.8	2.4	-0.3	-2.0	-1.1	1.9	-1.3
Arm fat percentage (left)	0.2	0.9	1.7	-0.9	-1.1	0.8	-0.5	-0.8	-1.0	-1.3	-0.5	1.2
Average weekly red wine intake	0.3	0.5	2.7	-1.6	-0.4	0.3	0.5	-0.1	-0.5	-0.3	-0.3	1.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.8	1.1	-0.3	0.5	-1.3	0.0	-0.2	-0.7	-0.9	-0.1
Mood swings	0.6	1.1	3.4	0.9	-0.6	-1.0	-1.1	-1.0	-0.4	-0.9	1.0	-1.8
Loneliness, isolation	0.6	0.8	5.2	1.0	-0.4	2.3	-0.4	0.5	-0.3	-0.1	-0.5	0.4
Long-standing illness, disability or infirmity	0.2	0.4	1.0	-0.8	-0.9	0.0	0.0	-0.2	-1.0	-0.8	-0.2	0.5
Ever had bowel cancer screening	1.0	1.2	3.8	1.3	1.0	1.2	0.2	0.7	0.8	0.8	-1.0	2.0
Diabetes diagnosed by doctor	0.2	0.4	0.9	-0.5	-1.0	-0.4	-0.7	-0.7	-0.9	-0.3	-0.4	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	2.0	0.1	0.1	-0.1	-1.4	-0.6	-0.1	-0.5	0.0	-1.2
Friendships satisfaction	0.6	0.8	2.4	-0.3	1.1	-0.3	1.0	0.4	1.3	1.6	0.5	-0.4
Qualifications: nursing, teaching	0.5	0.8	2.5	-0.7	0.5	-0.1	1.6	1.1	0.5	1.1	0.3	1.0
Commuting to job workplace: Walk	1.7	1.8	8.1	0.9	0.3	2.0	0.3	0.9	0.4	1.2	-1.1	2.8
Eye problems/disorders: Cataract	0.7	0.8	1.6	-1.2	-1.2	-0.6	-0.1	-0.6	-1.2	-0.9	0.6	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	0.7	0.5	0.4	-0.7	-0.6	0.5	0.7	-0.5	0.1
Medication for cholesterol	0.5	0.8	4.0	-0.9	0.5	-2.0	1.2	-0.2	0.3	0.6	0.8	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.2	-0.3	-1.4	-0.1	-0.0	-0.8	-1.4	-1.5	0.7	-1.3
Back pain experienced in last month	0.3	0.4	1.0	-0.8	0.7	-0.4	0.7	-0.2	0.6	1.0	0.4	0.4
Mineral and other dietary supplements	0.8	1.1	5.8	0.6	-0.3	-2.4	0.6	-0.2	-0.2	-0.4	0.8	-1.4
Breast cancer (self-reported)	1.1	1.3	4.7	0.0	1.8	-0.2	-2.2	0.5	1.6	0.2	-1.1	0.3
Asthma (self-reported)	0.3	0.6	1.3	-1.1	-0.7	-0.8	-0.4	-0.8	-0.6	-0.5	0.5	-1.1
Osteoporosis (self-reported)	0.7	0.9	4.1	1.2	0.3	-0.7	0.5	-0.3	0.3	-0.4	1.3	-2.0
Osteoarthritis (self-reported)	1.1	1.4	3.3	0.5	-1.0	-0.3	-1.4	-1.4	-1.0	-1.8	0.3	-1.7
Medication: Aspirin	0.7	0.9	2.4	1.5	-0.2	1.0	-1.0	-0.6	-0.3	-0.5	-0.8	1.5
Medication: Gliclazide	0.5	0.5	1.3	-0.7	-0.4	0.8	-0.6	1.1	-0.1	0.0	-0.8	1.1
Illnesses of father: None of the above (group 1)	1.3	1.6	4.2	-0.9	-0.8	-1.7	-1.3	-1.5	-0.9	-1.2	-0.0	-2.0
Smoking status: Current	1.5	2.3	9.6	-0.6	0.4	-3.1	1.5	-0.4	0.2	0.3	2.1	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.9	-0.2	-0.9	0.3	-1.0	0.8	-1.0	-0.1	-0.7	0.7
Whole body water mass	0.8	4.7	19.7	-4.4	-2.3	-1.8	1.7	-0.4	-2.3	-1.4	1.4	-1.5
Leg predicted mass (right)	1.0	5.1	22.1	-4.7	-2.1	-1.7	2.4	-0.3	-2.1	-1.2	1.9	-1.4
Arm fat mass (left)	0.3	1.2	3.8	-2.0	-1.5	0.0	0.1	-0.6	-1.4	-1.4	-0.1	0.7
Number of self-reported non-cancer illnesses	0.4	0.6	1.5	0.1	-0.9	1.0	-1.1	-0.2	-1.0	-1.2	-0.3	-0.2
Average weekly champagne plus white wine intake	0.8	1.1	2.0	0.7	1.1	0.7	-0.6	0.9	1.1	1.4	-1.3	1.3
Miserableness	0.1	0.2	0.6	-0.5	-0.6	-0.1	-0.1	-0.4	-0.5	-0.3	0.8	-0.6
Guilty feelings	0.4	0.6	1.4	0.8	-0.9	0.9	-1.2	-0.1	-0.9	-0.9	-0.2	-0.3
Wears glasses or contact lenses	0.6	0.7	1.6	-0.6	-1.1	0.8	0.3	-1.2	-1.3	-0.7	0.5	0.2
Ever taken oral contraceptive pill	1.5	1.6	4.8	-2.2	-0.1	-2.0	-0.1	0.9	-0.0	0.4	1.4	-1.7
Hearing aid user	0.2	0.3	0.7	-0.6	-0.3	0.1	0.8	0.4	-0.4	-0.0	0.8	0.3
Mother’s age at death	0.7	0.8	1.7	1.0	0.9	0.0	1.3	1.0	0.7	1.3	0.2	1.0
Financial situation satisfaction	0.4	0.5	2.2	-0.2	0.2	-0.0	-1.5	-0.2	0.2	-0.4	-0.2	-1.4
Tinnitus: Yes, now most or all of the time	1.1	1.3	5.2	0.1	0.0	2.3	-0.5	1.4	0.1	0.8	-1.4	1.1
Commuting to job workplace: Public transport	0.5	0.6	1.9	-0.7	-1.2	-0.3	0.4	0.1	-1.4	-0.7	0.8	-0.3
Eye problems/disorders: Glaucoma	2.3	2.8	7.1	1.8	1.2	2.1	-2.1	0.5	1.4	0.4	-2.7	1.4
Medication: Blood pressure	0.2	0.3	1.1	1.1	-0.6	0.7	-0.5	0.5	-0.3	-0.3	-0.5	-0.1
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.3	-0.1	1.2	1.4	1.2	1.0	1.2	1.3	-0.8	1.5
Supplements: Fish oil (including cod liver oil)	1.6	2.1	6.7	-0.0	1.6	2.0	-0.3	0.2	1.4	1.4	-1.1	2.6
High cholesterol (Self-reported)	0.4	0.7	2.2	1.0	0.3	1.5	-0.4	0.3	0.3	0.0	-1.0	1.5
Medication: Bendroflumethiazide	0.3	0.5	1.8	1.4	-0.9	-0.5	0.1	0.1	-0.8	-0.6	0.4	-0.1
Medication: Paracetamol	1.1	1.7	3.9	-0.8	-1.1	-0.7	1.7	-1.6	-1.1	-1.0	2.0	-1.4
Medication: Lisinopril	1.0	1.2	2.4	1.5	1.2	1.6	-0.6	0.0	1.0	1.3	-0.6	1.3
Medication: Atorvastatin	1.8	2.2	7.5	2.7	0.8	1.9	-1.0	-0.0	0.7	0.7	-1.7	1.7
Illnesses of father: High blood pressure	0.5	0.6	2.4	1.2	-0.0	0.4	0.7	1.6	0.0	0.9	0.1	0.1
Alcohol drinker status: Never	0.6	0.7	1.7	-0.4	0.6	1.3	-0.1	0.6	0.6	0.7	-1.1	1.2
Ever smoked	0.5	0.9	3.8	-0.9	0.3	-1.9	0.6	-0.5	0.2	0.5	0.9	-1.4
Basal metabolic rate	0.9	4.7	19.8	-4.5	-2.3	-1.9	1.6	-0.5	-2.3	-1.5	1.4	-1.2
Leg fat percentage (left)	0.2	0.8	2.6	-0.7	-0.3	-0.0	-1.2	-0.3	-0.2	-0.7	-1.3	1.6
Arm fat-free mass (left)	0.9	4.4	18.1	-4.3	-2.4	-1.9	1.1	-0.7	-2.4	-1.7	1.0	-1.0
Number of operations (self-reported)	0.7	1.0	3.7	0.9	0.3	1.9	-1.2	1.1	0.2	-0.2	-1.2	0.5
Average weekly beer plus cider intake	0.6	0.9	2.5	-0.0	-0.6	-1.5	-0.5	-0.7	-0.5	-1.0	1.1	-1.6
Irritability	0.7	1.1	4.2	-0.0	-0.5	-1.2	0.3	-2.0	-0.6	-0.4	1.5	-1.1
Risk taking	2.4	3.5	14.2	-3.8	-1.6	-2.5	-0.4	-0.9	-1.6	-1.3	1.0	-1.4
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.9	0.3	-0.0	0.1	-0.3	0.2	-0.3	0.0	-0.1	0.9
Fractured/broken bones in last 5 years	0.2	0.3	1.0	-0.3	0.7	-1.0	-0.1	0.1	0.6	0.7	-0.0	0.4
Age started oral contraceptive pill	1.1	1.4	5.4	0.9	0.6	2.3	-1.0	1.2	0.7	0.2	-1.7	0.7
Diastolic blood pressure, automated reading	0.4	1.3	3.6	1.9	-0.3	1.7	-1.5	-1.0	-0.1	-0.9	-1.0	-0.1
Ever depressed for a whole week	0.0	0.1	0.2	0.3	-0.2	0.1	-0.2	0.1	-0.3	-0.1	0.5	0.1
Unable to work because of sickness or disability	0.4	0.5	3.3	-0.1	0.2	-1.8	-1.0	0.2	0.2	-0.5	0.1	-0.2
Commuting to job workplace: Cycle	1.6	2.0	3.3	-1.2	-1.8	-0.7	1.0	-0.1	-1.8	-1.5	1.7	-1.8
Myopia	0.3	0.5	0.9	0.7	-0.9	-0.8	0.5	-1.0	-0.9	-0.2	0.3	-0.5
Vascular/heart problems diagnosed by doctor	0.8	2.2	9.4	-2.2	1.2	-3.1	0.8	-0.2	1.0	1.2	1.1	-0.8
Cholesterol lowering medication	1.2	1.8	6.0	1.6	0.3	2.4	-1.2	1.4	0.4	0.2	-1.6	1.1
Medication: Omeprazole (e.g. Zanprol)	3.9	4.8	12.2	-1.0	-2.2	-2.0	-0.5	-1.7	-2.3	-2.8	2.2	-3.5
Pain experienced in last month	0.1	0.2	1.1	0.3	0.1	-0.1	-0.3	1.0	-0.0	0.2	0.3	-0.3
Supplements: Calcium	0.6	0.7	1.7	0.2	0.7	0.8	1.3	1.3	0.6	0.8	0.0	0.6
Basal cell carcinoma (self-reported)	1.1	1.3	4.2	-1.0	-2.0	0.8	0.2	-0.3	-1.9	-1.1	-0.1	0.6
Heart attack/myocardial infarction (self-reported)	1.3	1.6	3.6	0.6	1.6	1.1	-0.6	0.5	1.6	1.1	-1.6	1.9
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	5.4	0.8	1.0	-1.3	-1.4	-0.0	1.1	-0.3	0.8	-2.3
Heart disease (siblings)	2.0	2.4	4.9	0.9	2.1	0.8	0.2	0.7	2.1	2.2	-1.2	2.2
Alcohol drinker status: Previous	0.4	0.4	2.1	0.5	0.5	-0.0	0.1	-0.7	0.3	0.8	-0.5	1.4
Pack years of smoking	3.2	4.7	9.8	-1.9	-1.3	-3.1	1.9	-2.9	-1.4	-1.0	2.8	-2.1
Impedance of whole body	0.4	2.1	4.4	2.0	2.0	0.2	-0.5	0.7	2.1	1.4	-0.9	1.7
Leg fat mass (left)	0.3	1.3	5.5	-2.4	-1.3	-0.7	0.1	-0.4	-1.2	-1.0	-0.4	0.9
Arm predicted mass (left)	0.9	4.5	19.0	-4.4	-2.4	-2.0	0.8	-0.6	-2.4	-1.7	1.0	-1.0