[Hub]/) : Traits : Blood White Count :

chr1:44,790,653-47,573,980

Best TWAS P=3.01e-21 · Best GWAS P=8.97e-19 conditioned to 0.253

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CCDC163P 0.30 0.36 lasso 2 0.35 8.1e-45 6.2 6.2 5.7e-10 0.63 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous MAST2 0.09 0.09 lasso 4 0.08 2.6e-07 -7.9 -8.1 6.4e-16 -0.62 0.84 0.16 FALSE
3 GTEx Adipose Subcutaneous GPBP1L1 0.05 0.05 lasso 4 0.05 8.7e-05 -7.7 -5.5 4.2e-08 -0.32 0.83 0.04 FALSE
4 GTEx Adipose Subcutaneous CCDC163P 0.66 0.72 lasso 7 0.73 8.2e-86 6.2 6.2 5.9e-10 0.64 1.00 0.00 FALSE
5 GTEx Adipose Visceral Omentum CCDC163P 0.43 0.50 lasso 6 0.52 6.1e-31 6.2 6.7 2.1e-11 0.65 1.00 0.00 FALSE
6 GTEx Adrenal Gland CCDC163P 0.54 0.61 lasso 6 0.60 1.2e-26 6.3 6.3 2.6e-10 0.64 1.00 0.00 FALSE
7 GTEx Artery Aorta MAST2 0.26 0.32 lasso 16 0.31 2.0e-17 -8.0 -8.1 7.0e-16 -0.57 0.80 0.20 FALSE
8 GTEx Artery Aorta TMEM69 0.09 0.02 enet 9 0.03 6.4e-03 -6.2 -8.4 3.6e-17 -0.76 0.19 0.70 FALSE
9 GTEx Artery Aorta CCDC163P 0.73 0.74 lasso 6 0.74 2.1e-59 6.2 6.2 4.6e-10 0.63 1.00 0.00 FALSE
10 GTEx Artery Coronary MAST2 0.09 0.09 lasso 4 0.08 1.3e-03 -8.0 -7.4 1.2e-13 -0.55 0.46 0.15 FALSE
11 GTEx Artery Coronary CCDC163P 0.72 0.76 lasso 9 0.76 1.6e-37 6.2 6.3 2.4e-10 0.64 1.00 0.00 FALSE
12 GTEx Artery Tibial MAST2 0.29 0.30 lasso 2 0.30 1.8e-23 -7.9 -7.9 3.6e-15 -0.55 0.91 0.09 FALSE
13 GTEx Artery Tibial GPBP1L1 0.04 0.04 enet 7 0.03 2.2e-03 4.7 -5.2 2.0e-07 -0.31 0.73 0.08 FALSE
14 GTEx Artery Tibial CCDC163P 0.67 0.75 lasso 7 0.75 5.8e-87 6.2 6.3 3.3e-10 0.64 1.00 0.00 FALSE
15 GTEx Brain Caudate basal ganglia CCDC163P 0.54 0.47 lasso 4 0.48 9.8e-16 6.3 6.3 2.6e-10 0.63 1.00 0.00 FALSE
16 GTEx Brain Cerebellar Hemisphere CCDC163P 0.58 0.60 lasso 7 0.65 1.7e-21 6.2 6.6 3.5e-11 0.69 0.99 0.01 FALSE
17 GTEx Brain Cerebellum CCDC163P 0.73 0.67 lasso 8 0.70 7.4e-28 6.2 6.4 1.2e-10 0.66 1.00 0.00 FALSE
18 GTEx Brain Cortex CCDC163P 0.34 0.45 enet 14 0.44 1.3e-13 6.3 6.3 2.2e-10 0.60 1.00 0.00 FALSE
19 GTEx Brain Frontal Cortex BA9 CCDC163P 0.58 0.47 lasso 8 0.45 1.5e-13 6.3 6.6 3.7e-11 0.67 1.00 0.00 FALSE
20 GTEx Brain Nucleus accumbens basal ganglia CCDC163P 0.36 0.36 lasso 4 0.36 1.2e-10 6.3 6.2 6.0e-10 0.63 0.91 0.07 FALSE
21 GTEx Brain Putamen basal ganglia CCDC163P 0.43 0.47 lasso 7 0.48 3.7e-13 6.3 6.5 1.1e-10 0.65 0.92 0.08 FALSE
22 GTEx Breast Mammary Tissue CCDC163P 0.45 0.61 lasso 9 0.60 1.8e-37 6.3 6.5 1.1e-10 0.66 1.00 0.00 FALSE
23 GTEx Breast Mammary Tissue (Male) CCDC163P 0.48 0.54 enet 21 0.52 5.5e-14 6.3 6.8 1.1e-11 0.70 0.82 0.18 FALSE
24 GTEx Cells EBV-transformed lymphocytes TESK2 0.15 0.10 lasso 5 0.10 4.5e-04 5.6 6.1 1.0e-09 0.36 0.40 0.27 FALSE
25 GTEx Cells EBV-transformed lymphocytes CCDC163P 0.52 0.56 enet 22 0.60 6.4e-24 6.3 6.6 3.3e-11 0.60 1.00 0.00 FALSE
26 GTEx Cells Transformed fibroblasts MAST2 0.25 0.33 enet 16 0.30 1.0e-22 -7.9 -8.2 3.0e-16 -0.55 0.88 0.12 FALSE
27 GTEx Cells Transformed fibroblasts FAAH 0.20 0.06 enet 27 0.14 8.6e-11 2.8 6.1 1.4e-09 0.58 0.04 0.95 FALSE
28 GTEx Cells Transformed fibroblasts MMACHC 0.09 0.04 lasso 3 0.08 1.5e-06 -3.5 -5.9 3.5e-09 -0.49 0.75 0.10 FALSE
29 GTEx Cells Transformed fibroblasts GPBP1L1 0.05 0.02 enet 21 0.02 1.1e-02 -8.0 -5.6 1.8e-08 -0.19 0.51 0.06 FALSE
30 GTEx Cells Transformed fibroblasts TMEM69 0.10 0.07 enet 10 0.07 3.0e-06 8.8 -8.1 5.3e-16 -0.90 0.01 0.99 FALSE
31 GTEx Cells Transformed fibroblasts CCDC163P 0.55 0.62 lasso 4 0.62 1.1e-58 6.2 6.2 5.0e-10 0.63 1.00 0.00 FALSE
32 GTEx Colon Sigmoid MAST2 0.18 0.10 lasso 4 0.13 2.5e-05 -7.9 -7.1 1.6e-12 -0.42 0.78 0.16 FALSE
33 GTEx Colon Sigmoid CCDC163P 0.55 0.62 lasso 5 0.64 1.7e-28 6.2 6.3 3.7e-10 0.63 1.00 0.00 FALSE
34 GTEx Colon Transverse MAST2 0.18 0.09 lasso 7 0.07 4.5e-04 -7.8 -7.6 2.2e-14 -0.59 0.32 0.58 FALSE
35 GTEx Colon Transverse CCDC163P 0.65 0.61 lasso 11 0.60 7.2e-35 6.2 6.3 2.7e-10 0.64 1.00 0.00 FALSE
36 GTEx Esophagus Gastroesophageal Junction CCDC163P 0.65 0.62 enet 14 0.63 1.3e-28 6.2 6.7 2.6e-11 0.62 1.00 0.00 FALSE
37 GTEx Esophagus Mucosa CCDC163P 0.59 0.69 enet 18 0.68 8.2e-62 6.3 6.4 1.9e-10 0.63 1.00 0.00 FALSE
38 GTEx Esophagus Muscularis MAST2 0.17 0.13 enet 30 0.11 3.8e-07 -8.0 -7.0 2.4e-12 -0.53 0.80 0.20 FALSE
39 GTEx Esophagus Muscularis CCDC163P 0.65 0.72 lasso 8 0.72 6.7e-62 6.2 6.3 3.0e-10 0.64 1.00 0.00 FALSE
40 GTEx Heart Atrial Appendage MAST2 0.22 0.07 lasso 15 0.12 5.3e-06 8.6 -9.5 3.0e-21 -0.88 0.04 0.96 TRUE
41 GTEx Heart Left Ventricle MAST2 0.21 0.08 lasso 7 0.10 5.5e-06 -6.2 -8.4 4.6e-17 -0.81 0.06 0.93 FALSE
42 GTEx Heart Left Ventricle CCDC163P 0.44 0.51 enet 41 0.54 3.1e-33 6.3 7.7 1.7e-14 0.74 1.00 0.00 FALSE
43 GTEx Liver CCDC163P 0.36 0.47 lasso 5 0.47 6.5e-15 6.3 6.2 4.1e-10 0.64 0.97 0.03 FALSE
44 GTEx Lung MAST2 0.06 0.06 lasso 5 0.05 1.7e-04 -7.9 -8.1 6.2e-16 -0.60 0.78 0.19 FALSE
45 GTEx Lung PRDX1 0.07 0.06 enet 16 0.05 5.3e-05 -3.5 5.8 4.8e-09 0.54 0.41 0.49 FALSE
46 GTEx Lung CCDC163P 0.56 0.70 lasso 7 0.70 1.6e-74 6.2 6.3 2.4e-10 0.64 1.00 0.00 FALSE
47 GTEx Muscle Skeletal RP11-767N6.7 0.06 0.06 lasso 3 0.04 6.6e-05 -6.3 -6.0 2.6e-09 -0.45 0.79 0.01 FALSE
48 GTEx Muscle Skeletal CCDC163P 0.29 0.42 enet 29 0.43 2.8e-45 6.3 7.0 2.0e-12 0.74 1.00 0.00 FALSE
49 GTEx Nerve Tibial MAST2 0.08 0.05 lasso 4 0.06 5.6e-05 -7.9 -9.3 2.1e-20 -0.81 0.06 0.92 FALSE
50 GTEx Nerve Tibial IPP 0.07 0.04 enet 12 0.05 1.9e-04 -6.2 -6.4 1.8e-10 -0.31 0.59 0.14 FALSE
51 GTEx Nerve Tibial CCDC163P 0.68 0.71 lasso 6 0.73 1.6e-73 6.2 6.3 3.1e-10 0.65 1.00 0.00 FALSE
52 GTEx Ovary CCDC163P 0.57 0.53 lasso 7 0.54 1.5e-15 6.4 6.3 3.3e-10 0.64 0.97 0.03 FALSE
53 GTEx Pancreas TESK2 0.14 0.07 lasso 2 0.07 5.7e-04 5.9 6.2 6.5e-10 0.41 0.57 0.05 FALSE
54 GTEx Pancreas ZSWIM5 0.14 0.02 lasso 3 0.03 1.4e-02 4.0 5.5 3.7e-08 0.15 0.23 0.04 FALSE
55 GTEx Pancreas CCDC163P 0.44 0.57 lasso 12 0.56 8.6e-28 6.2 7.0 2.7e-12 0.64 1.00 0.00 FALSE
56 GTEx Pituitary CCDC163P 0.68 0.70 lasso 8 0.70 9.7e-24 6.3 6.5 5.9e-11 0.65 1.00 0.00 FALSE
57 GTEx Prostate CCDC163P 0.77 0.70 lasso 11 0.68 5.1e-23 6.3 6.4 1.9e-10 0.63 1.00 0.00 FALSE
58 GTEx Skin Not Sun Exposed Suprapubic CCDC163P 0.71 0.76 lasso 7 0.77 3.6e-64 6.2 6.3 3.4e-10 0.64 1.00 0.00 FALSE
59 GTEx Skin Sun Exposed Lower leg CCDC163P 0.68 0.73 enet 30 0.74 3.0e-90 6.2 6.3 2.2e-10 0.69 1.00 0.00 FALSE
60 GTEx Small Intestine Terminal Ileum CCDC163P 0.63 0.40 enet 35 0.42 1.7e-10 6.3 5.8 5.8e-09 0.49 0.94 0.01 FALSE
61 GTEx Spleen CCDC163P 0.83 0.72 lasso 8 0.75 1.3e-27 6.2 6.3 3.2e-10 0.64 1.00 0.00 FALSE
62 GTEx Stomach CCDC163P 0.58 0.61 lasso 6 0.63 6.5e-38 6.2 6.5 5.9e-11 0.64 1.00 0.00 FALSE
63 GTEx Testis CCDC163P 0.61 0.64 lasso 9 0.63 6.3e-35 6.2 6.3 3.5e-10 0.63 1.00 0.00 FALSE
64 GTEx Thyroid IPP 0.08 0.07 lasso 3 0.08 7.1e-07 -8.0 -8.0 1.5e-15 -0.54 0.81 0.18 FALSE
65 GTEx Thyroid CCDC163P 0.62 0.68 lasso 10 0.71 6.1e-77 6.2 6.6 4.0e-11 0.69 1.00 0.00 FALSE
66 GTEx Uterus MAST2 0.30 0.28 lasso 2 0.18 2.0e-04 -7.9 -7.9 2.6e-15 -0.57 0.53 0.23 FALSE
67 GTEx Uterus CCDC163P 0.58 0.45 lasso 9 0.41 1.8e-09 6.4 6.6 4.1e-11 0.69 0.61 0.32 FALSE
68 GTEx Vagina CCDC163P 0.62 0.66 lasso 4 0.67 2.4e-20 6.2 6.2 4.2e-10 0.63 1.00 0.00 FALSE
69 GTEx Whole Blood CCDC163P 0.40 0.51 lasso 6 0.51 9.3e-54 6.2 6.2 4.4e-10 0.63 1.00 0.00 FALSE
70 METSIM Adipose CCDC163P 0.38 0.37 lasso 7 0.37 2.9e-58 6.3 6.5 9.3e-11 0.67 1.00 0.00 FALSE
71 METSIM Adipose CCDC17 0.03 0.02 blup 287 0.01 5.6e-03 -8.0 -7.0 2.9e-12 -0.34 0.36 0.16 FALSE
72 METSIM Adipose MAST2 0.06 0.06 lasso 6 0.05 1.3e-08 -7.9 -7.0 3.6e-12 -0.44 0.85 0.15 FALSE
73 NTR Blood CCDC163P 0.05 0.07 lasso 7 0.06 5.6e-20 6.2 6.4 2.0e-10 0.62 1.00 0.00 FALSE
74 NTR Blood PIK3R3 0.01 0.02 lasso 2 0.02 4.5e-06 -8.1 -8.0 1.3e-15 -0.55 0.82 0.17 FALSE
75 ROSMAP Brain Pre-frontal Cortex PIK3R3 0.05 0.02 lasso 4 0.03 4.4e-05 6.1 -6.0 2.7e-09 -0.59 0.29 0.53 FALSE
76 ROSMAP Brain Pre-frontal Cortex CCDC163P 0.53 0.64 bslmm 278 0.64 9.6e-107 6.2 6.3 3.1e-10 0.66 1.00 0.00 FALSE
77 YFS Blood TMEM69 0.02 0.01 bslmm 294 0.01 2.1e-04 -2.9 -6.3 3.5e-10 -0.57 0.25 0.43 FALSE
78 The Cancer Genome Atlas Bladder Urothelial Carcinoma CCDC163P 0.34 0.38 lasso 7 0.37 2.0e-32 6.3 6.4 1.2e-10 0.67 0.04 0.96 FALSE
79 The Cancer Genome Atlas Breast Invasive Carcinoma CCDC163P 0.27 0.43 enet 16 0.43 1.2e-97 6.3 6.0 2.0e-09 0.62 0.04 0.96 FALSE
80 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma CCDC163P 0.31 0.36 enet 14 0.36 9.7e-19 6.2 6.2 4.5e-10 0.63 0.04 0.96 FALSE
81 The Cancer Genome Atlas Colon Adenocarcinoma CCDC163P 0.15 0.24 lasso 10 0.22 3.4e-13 6.2 6.3 3.3e-10 0.62 0.03 0.97 FALSE
82 The Cancer Genome Atlas Esophageal Carcinoma CCDC163P 0.33 0.32 lasso 8 0.31 1.1e-10 6.2 6.2 6.8e-10 0.63 0.03 0.97 FALSE
83 The Cancer Genome Atlas Glioblastoma Multiforme CCDC163P 0.21 0.13 lasso 3 0.11 3.0e-04 6.3 6.3 2.2e-10 0.64 0.02 0.82 FALSE
84 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CCDC163P 0.19 0.38 lasso 3 0.36 9.1e-43 6.2 6.2 5.3e-10 0.63 0.05 0.95 FALSE
85 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CCDC163P 0.29 0.50 lasso 3 0.49 1.8e-62 6.3 6.3 2.2e-10 0.64 0.03 0.97 FALSE
86 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TESK2 0.02 0.01 blup 82 0.02 2.0e-03 -3.5 6.4 1.6e-10 0.52 0.06 0.69 FALSE
87 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma CCDC163P 0.32 0.51 lasso 7 0.51 1.2e-33 6.2 6.2 5.3e-10 0.65 0.03 0.97 FALSE
88 The Cancer Genome Atlas Brain Lower Grade Glioma MMACHC 0.06 0.02 enet 9 0.05 2.7e-06 6.3 -6.7 1.6e-11 -0.58 0.03 0.97 FALSE
89 The Cancer Genome Atlas Liver Hepatocellular Carcinoma CCDC163P 0.08 0.05 blup 37 0.04 5.0e-03 6.3 6.8 7.2e-12 0.68 0.02 0.90 FALSE
90 The Cancer Genome Atlas Lung Adenocarcinoma CCDC163P 0.26 0.41 lasso 8 0.41 3.5e-51 6.2 6.1 8.5e-10 0.61 0.04 0.96 FALSE
91 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CCDC163P 0.27 0.40 enet 9 0.40 3.2e-49 6.3 6.4 1.8e-10 0.63 0.04 0.96 FALSE
92 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MMACHC 0.06 0.02 enet 14 0.04 5.5e-05 6.3 5.4 6.7e-08 0.51 0.04 0.91 FALSE
93 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma CCDC163P 0.29 0.48 lasso 6 0.48 2.3e-36 6.2 6.3 3.9e-10 0.63 0.04 0.96 FALSE
94 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma MMACHC 0.07 0.02 blup 41 0.03 4.2e-03 -3.2 5.2 1.6e-07 0.50 0.04 0.76 FALSE
95 The Cancer Genome Atlas Pancreatic Adenocarcinoma CCDC163P 0.42 0.48 lasso 7 0.47 3.2e-22 6.2 6.3 2.3e-10 0.62 0.05 0.95 FALSE
96 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma CCDC163P 0.17 0.11 blup 37 0.14 4.4e-06 6.2 6.0 1.4e-09 0.63 0.03 0.97 FALSE
97 The Cancer Genome Atlas Prostate Adenocarcinoma CCDC163P 0.37 0.62 lasso 6 0.62 7.9e-82 6.2 6.2 4.6e-10 0.63 0.04 0.96 FALSE
98 The Cancer Genome Atlas Rectum Adenocarcinoma CCDC163P 0.21 0.17 enet 13 0.14 4.1e-04 6.4 6.5 8.3e-11 0.69 0.02 0.88 FALSE
99 The Cancer Genome Atlas Soft Tissue Sarcoma CCDC163P 0.16 0.17 blup 37 0.19 2.1e-11 6.4 5.9 3.7e-09 0.50 0.03 0.97 FALSE
100 The Cancer Genome Atlas Skin Cutaneous Melanoma CCDC163P 0.29 0.03 lasso 3 0.04 3.1e-02 6.3 6.9 7.0e-12 0.75 0.01 0.61 FALSE
101 The Cancer Genome Atlas Stomach Adenocarcinoma CCDC163P 0.10 0.12 blup 36 0.12 7.5e-09 6.2 6.5 1.1e-10 0.63 0.04 0.96 FALSE
102 The Cancer Genome Atlas Stomach Adenocarcinoma TMEM69 0.10 0.05 lasso 2 0.04 5.9e-04 -6.2 -6.2 4.1e-10 -0.49 0.18 0.32 FALSE
103 The Cancer Genome Atlas Testicular Germ Cell Tumors CCDC163P 0.09 0.03 blup 36 0.06 3.4e-03 6.2 6.5 8.5e-11 0.58 0.02 0.65 FALSE
104 The Cancer Genome Atlas Thyroid Carcinoma CCDC163P 0.38 0.64 enet 20 0.64 4.6e-82 6.2 6.5 1.0e-10 0.64 0.04 0.96 FALSE
105 The Cancer Genome Atlas Thyroid Carcinoma PRDX1 0.18 0.20 lasso 6 0.28 7.9e-27 -3.4 5.8 8.0e-09 0.55 0.30 0.70 FALSE
106 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma CCDC163P 0.11 0.06 blup 37 0.07 5.2e-03 6.2 6.4 2.0e-10 0.67 0.01 0.66 FALSE