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chr7:5,695,259-7,564,680

Best TWAS P=3.52e-19 · Best GWAS P=2.44e-21 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
25	ROSMAP	Brain Pre-frontal Cortex	RSPH10B2	0.16	0.09	enet	28	0.12	4.9e-15	-8.7	-8.9	3.5e-19	0.76	0.00	1.00	TRUE
15	GTEx	Esophagus Mucosa	PMS2CL	0.31	0.06	enet	26	0.11	1.1e-07	-2.6	-8.0	1.9e-15	0.19	0.28	0.03	TRUE
31	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PMS2CL	0.09	0.05	blup	22	0.06	7.9e-04	6.8	-7.7	1.8e-14	0.53	0.06	0.16	TRUE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	PMS2CL	0.10	0.12	blup	22	0.12	4.6e-14	7.9	-7.5	5.1e-14	0.41	1.00	0.00	TRUE
58	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF12	0.07	0.02	blup	32	0.05	2.8e-05	-7.6	-7.0	2.4e-12	0.79	0.04	0.88	TRUE
36	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C7orf28B	0.15	0.13	lasso	3	0.13	1.3e-14	5.2	-5.5	2.9e-08	0.36	0.00	1.00	TRUE
52	The Cancer Genome Atlas	Soft Tissue Sarcoma	C7orf28A	0.08	0.00	blup	11	0.02	2.6e-02	5.2	-5.5	5.1e-08	0.10	0.00	0.66	TRUE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	RSPH10B2	0.02	0.00	blup	11	0.00	1.2e-01	5.2	-8.4	5.0e-17	0.50	0.00	0.22	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	CCZ1B	0.54	0.32	lasso	9	0.40	1.8e-54	5.2	-8.1	6.3e-16	0.55	1.00	0.00	FALSE
14	GTEx	Esophagus Mucosa	CCZ1B	0.28	0.21	enet	47	0.24	9.0e-16	5.2	-7.9	3.0e-15	0.48	1.00	0.00	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	RP11-611L7.1	0.19	0.18	enet	17	0.15	3.9e-19	-7.6	-7.7	1.4e-14	0.88	1.00	0.00	FALSE
23	METSIM	Adipose	CCZ1B	0.22	0.14	bslmm	400	0.13	1.7e-19	5.2	-7.7	2.0e-14	0.45	1.00	0.00	FALSE
21	GTEx	Testis	PMS2CL	0.53	0.28	lasso	12	0.28	6.4e-13	6.1	-7.6	3.4e-14	0.41	1.00	0.00	FALSE
6	GTEx	Artery Tibial	CCZ1B	0.34	0.20	enet	27	0.23	4.0e-18	5.2	-7.5	5.5e-14	0.48	1.00	0.00	FALSE
22	GTEx	Thyroid	PMS2CL	0.10	0.07	lasso	3	0.07	6.5e-06	7.9	-7.4	9.8e-14	0.54	0.69	0.08	FALSE
28	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PMS2CL	0.12	0.12	lasso	3	0.13	4.1e-11	6.8	-7.4	1.3e-13	0.50	1.00	0.00	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	PMS2CL	0.08	0.12	lasso	5	0.11	1.0e-10	7.3	-7.3	2.4e-13	0.56	1.00	0.00	FALSE
12	GTEx	Colon Sigmoid	PMS2CL	0.21	0.07	lasso	4	0.07	1.6e-03	6.8	-7.3	3.5e-13	0.56	0.15	0.24	FALSE
35	The Cancer Genome Atlas	Glioblastoma Multiforme	PMS2CL	0.22	0.03	lasso	2	0.10	5.9e-04	6.1	-7.2	6.9e-13	0.37	0.06	0.07	FALSE
55	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PMS2CL	0.14	0.10	lasso	2	0.07	1.5e-03	7.3	-7.2	8.5e-13	0.56	0.04	0.07	FALSE
59	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	C7orf28B	0.16	0.11	blup	6	0.14	1.4e-04	5.2	-7.1	1.6e-12	0.35	0.00	0.73	FALSE
10	GTEx	Cells Transformed fibroblasts	CCZ1B	0.25	0.20	lasso	3	0.22	1.9e-16	5.2	-7.0	2.7e-12	0.44	1.00	0.00	FALSE
33	The Cancer Genome Atlas	Colon Adenocarcinoma	PMS2CL	0.04	0.06	enet	4	0.06	1.9e-04	7.3	-6.8	1.2e-11	0.54	0.08	0.10	FALSE
11	GTEx	Cells Transformed fibroblasts	PMS2CL	0.15	0.08	lasso	5	0.10	8.6e-08	4.2	-6.7	2.1e-11	0.48	0.70	0.04	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	RSPH10B2	0.04	0.05	lasso	3	0.04	1.9e-05	6.8	-6.7	2.4e-11	0.43	0.12	0.79	FALSE
18	GTEx	Nerve Tibial	PMS2CL	0.19	0.04	enet	10	0.08	2.0e-06	4.2	-6.6	3.3e-11	0.55	0.18	0.76	FALSE
17	GTEx	Nerve Tibial	ZNF12	0.16	0.10	enet	7	0.15	5.3e-11	6.8	-6.6	3.9e-11	0.47	0.99	0.00	FALSE
27	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C7orf28B	0.16	0.16	enet	4	0.16	1.2e-13	5.2	-6.4	1.7e-10	0.37	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PMS2CL	0.06	0.05	blup	22	0.05	1.1e-06	6.8	-6.3	2.2e-10	0.34	0.94	0.00	FALSE
51	The Cancer Genome Atlas	Prostate Adenocarcinoma	PMS2CL	0.05	0.07	blup	22	0.07	3.4e-08	6.8	-6.3	2.2e-10	0.58	0.97	0.03	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C7orf28B	0.08	0.08	enet	4	0.08	3.4e-09	5.2	-6.2	4.7e-10	0.37	0.00	1.00	FALSE
54	The Cancer Genome Atlas	Stomach Adenocarcinoma	C7orf28B	0.09	0.07	blup	6	0.07	1.1e-05	5.2	-6.2	7.6e-10	0.34	0.00	0.99	FALSE
39	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C7orf28B	0.09	0.08	enet	3	0.07	1.2e-04	5.2	-6.0	1.6e-09	0.34	0.00	0.98	FALSE
32	The Cancer Genome Atlas	Colon Adenocarcinoma	C7orf28B	0.08	0.05	blup	6	0.07	4.6e-05	5.2	-6.0	2.2e-09	0.35	0.00	0.83	FALSE
8	GTEx	Breast Mammary Tissue (Male)	CCZ1B	0.51	0.14	lasso	9	0.20	2.3e-05	4.2	-6.0	2.7e-09	0.52	0.06	0.20	FALSE
44	The Cancer Genome Atlas	Lung Adenocarcinoma	PMS2CL	0.08	0.06	blup	22	0.06	4.4e-07	6.8	-6.0	2.7e-09	0.39	0.90	0.01	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	C7orf28B	0.10	0.12	lasso	2	0.12	2.4e-12	5.2	-5.9	3.6e-09	0.38	0.00	1.00	FALSE
46	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PMS2CL	0.06	0.06	blup	22	0.07	1.9e-08	6.8	-5.9	3.7e-09	0.40	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	PMS2CL	0.12	0.04	lasso	4	0.04	1.9e-04	4.2	-5.9	4.8e-09	0.47	0.62	0.02	FALSE
7	GTEx	Breast Mammary Tissue	CCZ1B	0.42	0.19	lasso	7	0.14	1.2e-07	5.2	-5.7	1.1e-08	0.41	0.98	0.00	FALSE
19	GTEx	Ovary	PMS2CL	0.48	0.13	lasso	5	0.19	2.3e-05	7.9	-5.6	2.2e-08	0.43	0.07	0.22	FALSE
4	GTEx	Adipose Visceral Omentum	CCZ1B	0.31	0.17	lasso	4	0.17	2.4e-09	5.2	-5.5	3.2e-08	0.37	0.95	0.03	FALSE
2	GTEx	Adipose Subcutaneous	CCZ1B	0.35	0.23	lasso	3	0.22	5.9e-18	5.2	-5.5	3.5e-08	0.37	1.00	0.00	FALSE
53	The Cancer Genome Atlas	Soft Tissue Sarcoma	C7orf28B	0.14	0.11	lasso	4	0.10	2.5e-06	5.2	-5.5	3.8e-08	0.37	0.00	1.00	FALSE
49	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C7orf28B	0.24	0.23	lasso	3	0.22	3.4e-09	5.2	-5.5	4.7e-08	0.36	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ZDHHC4	0.15	0.07	enet	23	0.12	4.9e-14	2.5	-5.5	4.9e-08	0.38	0.99	0.01	FALSE
43	The Cancer Genome Atlas	Lung Adenocarcinoma	C7orf28B	0.10	0.12	lasso	4	0.12	2.1e-13	5.2	-5.4	5.6e-08	0.35	0.00	1.00	FALSE
13	GTEx	Colon Transverse	CCZ1B	0.33	0.13	lasso	9	0.09	4.2e-05	5.2	-5.4	6.0e-08	0.20	0.47	0.03	FALSE
34	The Cancer Genome Atlas	Glioblastoma Multiforme	C7orf28B	0.22	0.14	lasso	2	0.14	5.9e-05	3.9	-5.4	7.1e-08	0.19	0.01	0.28	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	C7orf28B	0.12	0.10	lasso	2	0.10	3.5e-20	5.2	-5.4	7.9e-08	0.36	0.00	1.00	FALSE
16	GTEx	Nerve Tibial	CCZ1B	0.41	0.27	lasso	3	0.26	1.8e-18	5.2	-5.3	8.6e-08	0.37	1.00	0.00	FALSE
20	GTEx	Skin Sun Exposed Lower leg	CCZ1B	0.21	0.13	lasso	5	0.12	5.2e-10	5.2	-5.3	9.2e-08	0.38	1.00	0.00	FALSE
47	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C7orf28B	0.08	0.10	enet	2	0.09	6.2e-07	5.2	-5.2	1.8e-07	0.33	0.00	1.00	FALSE
48	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C7orf28B	0.08	0.06	lasso	2	0.04	1.3e-02	5.2	-5.2	1.8e-07	0.33	0.00	0.61	FALSE
5	GTEx	Artery Aorta	CCZ1B	0.18	0.22	lasso	2	0.21	7.9e-12	5.2	-5.2	2.1e-07	0.36	1.00	0.00	FALSE
9	GTEx	Breast Mammary Tissue (Female)	CCZ1B	0.07	0.22	lasso	1	0.21	7.0e-07	5.2	-5.2	2.2e-07	0.35	0.23	0.05	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	C7orf28B	0.10	0.12	lasso	1	0.11	8.7e-13	5.2	-5.2	2.2e-07	0.35	0.00	1.00	FALSE
45	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C7orf28B	0.08	0.09	lasso	1	0.08	2.6e-09	5.2	-5.2	2.2e-07	0.35	0.00	1.00	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	C7orf28B	0.12	0.14	lasso	1	0.14	1.1e-13	5.2	-5.2	2.2e-07	0.35	0.00	1.00	FALSE