TWAS hub - RSPH10B2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.1624	0.0340	7.8e-12	0.090	0.106	0.119	0.115	0.112	1.1e-11	1.6e-13	4.9e-15	1.4e-14	3.5e-14
2	TCGA	Breast Invasive Carcinoma	0.0172	0.0117	6.1e-03	-0.001	0.002	-0.001	NA	-0.001	4.7e-01	1.2e-01	6.5e-01	NA	4.7e-01
3	TCGA	Glioblastoma Multiforme	0.1850	0.0950	5.4e-03	-0.010	0.084	0.064	NA	0.079	9.4e-01	1.6e-03	5.5e-03	NA	2.1e-03
4	TCGA	Brain Lower Grade Glioma	0.0408	0.0203	2.2e-05	0.049	0.036	0.026	NA	0.041	2.6e-06	5.7e-05	5.3e-04	NA	1.9e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Happiness	7.2	8.7	11.1	2.8	3.0	2.6	3.3
Blood White Count	6.6	49.2	80.1	-8.9	-8.4	-1.4	-6.7
Body Mass Index (BMI) (2010)	4.8	6.5	10.6	-2.8	-2.6	-1.0	-3.3
Average weekly spirits intake	4.7	5.8	10.5	-3.2	-2.0	-1.3	-2.6
Medication: Seretide 50 evohaler	4.2	4.9	7.9	-2.3	-2.5	0.0	-2.8
Friendships satisfaction	4.0	5.0	10.1	1.7	2.2	3.2	1.5
Age at first live birth	3.8	6.7	10.0	2.5	3.0	1.2	3.2
Alcohol drinker status: Previous	3.7	4.2	7.0	-2.6	-2.4	-1.5	-1.3
Body fat percentage	3.6	14.2	23.6	-4.9	-4.0	-2.2	-3.6
Leg fat percentage (right)	3.6	13.2	24.0	-4.9	-3.9	-2.2	-3.0
Leg fat mass (right)	3.6	14.1	23.9	-4.9	-4.6	-1.9	-2.7
Leg fat percentage (left)	3.6	13.2	22.5	-4.7	-3.8	-2.3	-3.3
Leg fat mass (left)	3.5	13.7	22.4	-4.7	-4.5	-2.0	-2.8
Arm fat percentage (right)	3.4	13.3	21.0	-4.6	-4.2	-1.6	-3.4
Arm fat mass (right)	3.2	13.3	21.9	-4.5	-4.7	-1.6	-2.9
Whole body fat mass	3.2	13.4	21.3	-4.6	-4.5	-1.7	-3.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.1	3.7	5.3	2.2	2.3	-0.1	2.1
Commuting to job workplace: Public transport	3.1	3.7	5.6	1.8	2.4	1.4	2.0
Trunk fat percentage	2.9	11.8	19.0	-4.4	-3.6	-2.2	-3.3
Neck or shoulder pain in last month	2.9	4.2	7.5	-2.7	-2.5	0.7	-1.5
Arm fat percentage (left)	2.9	11.7	18.1	-4.2	-4.0	-1.5	-3.2
Respiratory disease	2.8	6.2	8.9	-3.0	-2.6	0.5	-2.9
Other serious medical condition/disability diagnosed by doctor	2.8	3.7	5.0	-2.2	-2.0	1.2	-2.0
Trunk fat mass	2.8	11.8	18.4	-4.3	-4.1	-2.0	-2.9
Chronic bronchitis/emphysema (father)	2.7	3.2	11.1	0.7	0.7	3.3	0.7
Length of working week for main job	2.7	3.0	6.0	-2.5	-2.2	-0.8	0.7
Arm fat mass (left)	2.7	11.2	19.6	-4.1	-4.4	-1.3	-2.6
Breastfed as a baby	2.6	3.2	5.3	1.5	2.1	1.0	2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	2.6	3.9	5.8	1.8	2.1	2.4	1.5
Pulse wave peak to peak time	2.6	3.1	4.0	2.0	1.5	1.6	1.9
Body mass index (BMI)	2.5	10.7	18.8	-4.1	-4.3	-1.6	-2.2
Alcohol intake versus 10 years previously	2.5	3.7	5.9	-2.4	-2.3	-1.3	-1.5
Medication: Gliclazide	2.5	2.8	6.7	-1.8	-1.1	0.3	-2.6
Tense / ‘highly strung’	2.4	4.0	4.6	1.8	2.1	1.9	2.1
Pulse wave reflection index	2.4	3.0	4.4	-1.6	-1.7	-1.4	-2.1
Family relationship satisfaction	2.4	3.0	3.7	1.7	1.9	1.4	1.9
Pulse wave Arterial Stiffness index	2.3	2.7	3.2	-1.8	-1.5	-1.6	-1.7
Schizophrenia vs Biploar Disorder	2.2	2.9	11.4	-3.4	0.0	0.0	0.0
Illnesses of siblings	2.1	3.0	6.8	1.0	2.6	1.2	1.6
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	4.6	-1.2	-1.9	0.2	-2.1
Hip circumference	2.0	8.6	15.1	-3.5	-3.9	-1.2	-2.4
Blood Red Count	1.9	18.1	24.2	-4.9	-4.9	-2.5	-4.2
Lung FVC	1.9	9.5	20.7	4.5	2.8	2.9	0.9
Wheeze or whistling in the chest in last year	1.9	3.3	6.2	-2.5	-1.7	1.0	-1.8
BMI	1.8	10.2	21.8	-4.0	-4.7	-0.9	-1.4
Weight	1.8	8.6	17.8	-3.4	-4.2	-1.2	-1.8
Asthma	1.8	3.5	6.9	-1.8	-1.2	1.5	-2.6
Asthma (self-reported)	1.8	3.6	6.8	-1.9	-1.3	1.5	-2.6
Hypothyroidism (self reported)	1.7	4.0	7.8	-1.2	-2.8	-1.2	-2.2
Waist circumference	1.7	6.1	9.4	-3.1	-3.0	-1.7	-1.7
Ever depressed for a whole week	1.7	2.1	6.2	1.0	0.8	2.5	0.6
Intelligence (Savage-Jansen 2018)	1.6	5.0	12.6	1.2	1.8	1.6	3.5
Age at last live birth	1.6	2.4	3.5	1.6	1.8	-0.1	1.9
Knee pain experienced in last month	1.6	2.4	5.5	-2.3	-2.0	0.6	-0.0
Illnesses of siblings: Diabetes	1.6	2.0	4.8	-0.5	-2.2	-0.3	-1.6
Mineral and other dietary supplements	1.6	2.1	3.2	1.4	0.9	-1.8	1.6
Financial situation satisfaction	1.6	2.0	6.4	0.7	0.8	2.5	-0.7
Age started oral contraceptive pill	1.6	2.0	5.6	-1.5	-0.2	-0.6	-2.4
Basal cell carcinoma (self-reported)	1.6	1.8	4.3	-0.1	-1.5	2.1	-0.9
Ovarian Cancer	1.5	2.0	4.2	2.0	0.7	0.5	1.8
Medication: Lansoprazole	1.5	1.7	4.3	-1.2	-2.1	0.4	-0.8
Blood clot in the leg (DVT)	1.5	1.9	4.3	0.2	0.5	1.8	2.1
Worry too long after embarrassment	1.5	2.5	4.2	1.3	2.0	2.0	0.7
Hypertension (Self-reported)	1.5	4.1	8.8	-2.3	-1.3	-3.0	-0.9
Qualifications: nursing, teaching	1.5	2.3	5.1	1.5	0.8	1.1	2.3
Osteoarthritis (self-reported)	1.5	1.9	5.8	-0.4	-0.5	2.4	-1.2
Hearing aid user	1.5	1.7	6.6	-0.5	-0.1	-2.6	-0.4
Breast Cancer	1.4	3.3	4.5	-1.5	-1.7	2.1	-1.9
Primary Biliary Cirrhosis	1.4	2.0	4.1	-0.7	-0.8	-1.6	-2.0
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	4.5	2.1	0.3	-0.1	2.0
Health satisfaction	1.4	1.8	3.7	-0.2	1.2	1.4	1.9
Commuting to job workplace: Car/motor vehicle	1.4	1.6	3.9	-1.0	-2.0	-0.7	-1.1
Myopia	1.4	2.1	6.3	0.5	2.5	-0.5	1.2
Relative age of first facial hair	1.3	2.7	3.6	-1.3	-1.9	1.4	-1.9
High blood pressure	1.3	3.5	7.2	-2.2	-1.1	-2.7	-1.1
Pain all over the body in last month	1.3	1.4	3.2	-1.2	-0.6	0.6	-1.8
Father’s age at death	1.3	1.8	4.6	0.1	1.5	2.1	0.4
Forced expiratory volume in 1-second (FEV1)	1.3	4.3	7.3	2.2	0.1	2.7	2.2
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	2.6	-1.6	-1.1	0.5	-1.6
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	3.1	1.3	1.0	-0.9	1.8
Headache pain in last month	1.3	2.2	3.1	-1.4	-1.8	1.3	-1.3
Hypothyroidism/myxoedema (self-reported)	1.3	2.6	4.9	-1.0	-2.2	-1.4	-1.6
Migraine (self-reported)	1.3	1.6	3.1	0.9	1.2	1.0	1.8
Medication for cholesterol	1.3	2.0	4.8	1.1	0.8	-2.2	1.2
Supplements: Fish oil (including cod liver oil)	1.3	1.7	3.9	-0.9	-0.5	2.0	-1.4
Diastolic blood pressure, automated reading	1.3	4.1	6.0	-2.4	-2.1	-2.1	-1.3
Unable to work because of sickness or disability	1.3	1.7	4.0	-2.0	-1.5	-0.4	-0.7
Major Depression (MDD)	1.2	1.5	6.1	2.5	0.0	0.0	0.0
Ever used hormone-replacement therapy (HRT)	1.2	1.5	5.4	-0.2	0.5	2.3	-0.5
Mouth/teeth dental problems: Dentures	1.2	2.1	3.9	-1.3	-1.1	-2.0	-1.2
Chronic bronchitis/emphysema (mother)	1.2	1.4	3.9	-0.4	-1.1	0.4	-2.0
Alcohol intake frequency.	1.2	2.9	3.8	-1.5	-1.9	-1.5	-1.7
Vascular/heart problems diagnosed by doctor	1.2	3.3	5.8	2.0	1.2	2.4	1.4
Alzheimer’s Disease (in mother)	1.1	1.3	3.6	0.7	1.0	0.1	1.9
Crohns Disease (2017)	1.1	2.5	4.1	-1.8	-2.0	0.4	-1.6
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	3.9	0.0	0.5	2.0	1.2
Fluid intelligence score	1.1	2.2	4.0	1.1	1.2	1.5	2.0
Qualifications: A levels/AS levels or equivalent	1.1	2.4	5.0	2.2	1.1	0.9	1.6
Prospective memory result	1.1	1.3	4.2	-0.5	-0.5	-0.8	-2.0
Comparative body size at age 10	1.1	3.1	8.8	-0.9	-1.6	-3.0	-0.3
Mean time to correctly identify matches	1.1	2.1	4.4	-1.1	-0.6	-2.1	-1.7
Long-standing illness, disability or infirmity	1.1	1.6	3.0	-1.5	-0.9	0.7	-1.7
Average weekly beer plus cider intake	1.1	1.6	3.9	2.0	1.5	0.3	-0.1
Depression (Nagel 2018)	1.0	1.5	3.2	-1.8	-1.4	-0.2	-1.0
Irritable Bowel Disease (IBD)	1.0	2.3	3.9	-1.7	-2.0	0.6	-1.5
Verbal and Numeric Reasoning (VNR)	1.0	2.4	4.3	0.9	1.8	1.2	2.1
Prostate Cancer	1.0	1.3	3.4	1.0	1.8	0.6	0.8
Systolic blood pressure, automated reading	1.0	3.0	4.3	-2.1	-1.5	-2.0	-1.3
Leg fat-free mass (left)	1.0	5.5	14.8	-2.4	-3.9	-0.6	-0.9
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	3.1	-1.0	-0.3	-0.8	-1.8
Leg predicted mass (left)	1.0	5.2	14.1	-2.4	-3.8	-0.6	-0.8
Forced vital capacity (FVC)	1.0	3.7	7.0	2.3	0.3	2.6	1.5
Forced vital capacity (FVC), Best measure	1.0	3.8	8.1	2.0	0.6	2.8	1.6
Leg pain on walking	1.0	1.3	2.3	-1.3	-1.5	0.7	-0.8
Illnesses of father: None of the above (group 1)	1.0	1.2	3.3	0.3	0.9	-0.9	1.8
Basal metabolic rate	1.0	5.4	14.5	-2.4	-3.8	-0.3	-1.1
Arm fat-free mass (left)	1.0	5.3	14.4	-2.3	-3.8	-0.4	-1.1
Supplements: Calcium	1.0	1.1	1.6	1.3	0.6	1.0	1.2
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	2.7	0.1	0.3	1.5	1.6
LDL Cholesterol	0.9	1.5	3.0	-1.7	-1.4	0.2	-0.8
Hearing difficulty/problems: Yes	0.9	1.4	3.5	-1.9	-1.0	0.8	-0.6
Taking other prescription medications	0.9	1.4	3.1	-1.2	-1.0	0.2	-1.8
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	3.5	-1.9	-0.8	-0.0	-1.3
Depression (self-reported)	0.9	1.1	2.7	0.0	1.2	1.7	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	6.0	1.6	0.1	2.4	1.6
Exposure to tobacco smoke at home	0.9	1.0	1.4	-1.0	-1.2	1.1	-0.5
Peak expiratory flow (PEF)	0.9	2.0	5.3	1.4	-0.3	2.3	0.9
Medication: Ventolin 100micrograms inhaler	0.9	1.1	1.5	-1.1	-0.7	1.1	-1.2
Emphysema/chronic bronchitis	0.9	1.0	2.5	-0.8	-1.0	0.1	-1.6
Medication: Blood pressure	0.9	1.7	4.0	-1.5	0.4	-2.0	-0.4
Illnesses of father: Heart disease	0.9	1.2	2.0	-0.7	-1.4	1.2	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	3.5	0.8	-0.1	0.2	1.9
Medication: Atorvastatin	0.9	1.1	2.1	0.8	1.5	1.2	0.1
Heart disease (siblings)	0.9	1.1	2.8	-1.0	-1.7	-0.7	-0.2
Arm predicted mass (left)	0.9	4.6	12.5	-2.2	-3.5	-0.3	-0.9
Townsend deprivation index at recruitment	0.8	1.1	2.1	1.4	1.1	-0.4	0.9
Qualifications: CSEs or equivalent	0.8	1.0	2.8	-0.2	-1.7	-0.5	-1.0
Hayfever, allergic rhinitis or eczema	0.8	1.7	3.3	1.1	1.8	1.3	0.8
Supplements: Glucosamine	0.8	1.0	1.4	-1.2	-1.2	0.6	-1.0
Alcohol usually taken with meals	0.8	1.3	2.9	-1.7	-0.3	1.4	-0.7
Qualifications: None of the above	0.8	1.6	3.8	-1.4	-0.5	-0.7	-1.9
Medication: Paracetamol	0.8	1.3	3.5	0.9	0.8	1.9	-0.3
Gout (self-reported)	0.8	1.0	2.4	-0.8	-1.1	0.1	-1.5
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.1	1.1	0.6	-0.1	1.4
Medication for pain relief, constipation, heartburn	0.8	1.3	1.8	1.0	0.7	-1.4	1.4
Had major operations	0.8	0.9	2.6	-0.9	-0.3	-0.4	-1.6
Leg fat-free mass (right)	0.8	4.4	12.7	-2.0	-3.6	-0.6	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.0	-1.4	-0.5	-0.1	-1.0
Leg predicted mass (right)	0.8	4.4	12.7	-2.0	-3.6	-0.6	-0.7
Medication: Lisinopril	0.8	1.0	1.7	-1.3	-1.0	-1.2	-0.2
Cholesterol lowering medication	0.8	1.2	2.2	-1.4	-0.1	0.7	-1.5
Ever had hysterectomy (womb removed)	0.7	0.8	2.6	0.0	-0.8	0.3	-1.6
Vitamin and mineral supplements	0.7	1.0	3.2	0.6	0.1	-0.6	1.8
Average weekly fortified wine intake	0.7	0.8	1.6	-1.3	-1.0	-0.0	-0.7
Relative age voice broke	0.7	1.1	1.8	-1.2	-0.7	1.3	-0.9
Number of incorrect matches in round	0.7	1.2	2.6	-0.5	1.0	-1.6	-1.0
Financial difficulties in last 2 years	0.7	0.9	2.0	-1.2	-0.3	-0.3	-1.4
Allergy	0.7	1.5	5.5	0.6	-0.4	-2.4	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.3	1.1	0.8	-0.1	1.1
Birth weight of first child	0.7	1.3	4.4	-0.2	-0.8	2.1	0.3
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.0	1.4	0.3	1.3	0.7
High blood pressure (siblings)	0.7	1.0	2.3	-0.0	-1.1	-1.5	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.1	-0.0	0.5	1.8	0.6
Whole body fat-free mass	0.7	4.1	12.2	-1.9	-3.5	-0.0	-0.7
Commuting to job workplace: Walk	0.7	0.7	2.3	0.2	0.7	-1.5	0.3
Breast cancer (self-reported)	0.7	0.8	1.8	-0.4	-1.3	-0.7	-0.8
Whole body water mass	0.7	4.2	12.6	-1.9	-3.5	-0.1	-0.7
Number of self-reported non-cancer illnesses	0.7	1.2	1.6	-1.3	-1.1	1.0	-1.0
Ever taken oral contraceptive pill	0.7	0.8	2.2	-0.3	1.0	0.1	1.5
Worry (Nagel 2018)	0.6	1.3	2.3	1.5	1.1	1.0	0.9
Ulcerative Colitis (UC)	0.6	1.1	1.8	-1.0	-1.4	0.4	-1.2
Schizophrenia (2014)	0.6	1.3	5.2	-2.3	0.0	0.0	0.0
Number of treatments/medications taken	0.6	1.0	1.6	-1.1	-0.9	1.3	-0.7
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.8	-0.0	0.9	1.4	-0.2
Multivitamins +/- minerals	0.6	0.8	1.4	1.2	1.0	0.7	-0.3
Hearing difficulty/problems with background noise	0.6	1.0	2.0	-0.6	-0.3	1.3	-1.4
Hair/balding pattern: Pattern 2	0.6	0.8	2.0	-0.0	-1.1	-0.2	-1.4
Arm fat-free mass (right)	0.6	2.9	9.1	-1.5	-3.0	0.1	-0.4
Exposure to tobacco smoke outside home	0.6	0.8	1.4	-0.9	-1.2	-0.4	-0.8
Chest pain or discomfort	0.6	0.8	2.6	-1.6	-0.2	0.7	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.5	0.8	0.6	-0.4	1.2
Ever had bowel cancer screening	0.6	0.7	2.1	-0.4	1.5	0.7	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.7	1.3	0.4	1.0	1.6
Irritability	0.6	1.0	2.0	-1.4	0.6	1.2	-0.5
Schizophrenia (2018)	0.5	1.1	4.4	-2.1	0.0	0.0	0.0
Alzheimer’s Disease (in father)	0.5	0.6	0.8	-0.7	-0.5	-0.9	-0.9
Coronary Artery Disease (CAD)	0.5	0.6	2.4	-1.6	0.0	0.0	0.0
HbA1C	0.5	0.6	1.1	-0.3	0.5	-0.8	-1.1
Lung FEV1/FVC ratio	0.5	2.5	4.9	-2.2	-2.0	-0.9	-0.1
Diabetes (mother)	0.5	0.6	1.9	-0.1	-0.7	-0.1	-1.4
Impedance of leg (right)	0.5	2.3	8.1	0.8	2.9	0.5	0.1
Maternal smoking around birth	0.5	0.8	2.6	-0.7	-1.6	-0.1	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.4	-1.6	0.4	0.1	-0.2
Medication: Atenolol	0.5	0.6	1.2	0.7	0.6	-1.1	0.5
High blood pressure (mother)	0.5	0.8	1.5	-1.2	-0.2	-1.2	0.1
Impedance of leg (left)	0.5	2.3	8.1	1.0	2.9	0.3	-0.1
Medication: Simvastatin	0.5	0.7	1.4	-0.8	0.2	-0.7	-1.2
Trunk fat-free mass	0.5	3.0	9.4	-1.4	-3.1	0.4	-0.5
Number of live births	0.5	0.6	1.6	0.9	0.3	1.3	-0.4
Trunk predicted mass	0.5	3.0	9.3	-1.5	-3.0	0.5	-0.5
Number of full brothers	0.5	0.6	1.3	0.8	-0.1	0.6	1.1
Qualifications: College or University degree	0.5	1.6	2.4	0.5	1.3	1.5	1.6
Medication: Ibuprofen	0.5	0.6	0.8	-0.9	-0.9	0.9	-0.4
Arm predicted mass (right)	0.5	2.8	8.9	-1.5	-3.0	0.1	-0.2
Comparative height size at age 10	0.5	2.8	3.6	-1.8	-1.9	-1.8	-1.0
Supplements: Vitamin C	0.5	0.6	2.0	-0.2	-0.7	1.4	-0.2
Mood swings	0.5	0.8	1.7	-1.3	-0.6	0.8	-0.8
Eye problems/disorders: Cataract	0.5	0.6	1.6	-0.4	-0.4	1.3	0.5
Mother’s age at death	0.5	0.6	1.7	0.4	0.5	1.3	0.4
Medication: Paracetamol	0.5	0.8	2.0	0.6	0.8	1.4	0.4
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.7	-1.3	-0.3	0.5	0.5
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.6	0.6	1.2	-0.3	0.8
Impedance of whole body	0.5	2.4	7.6	1.4	2.8	0.4	-0.3
Reaction Time	0.4	0.7	2.1	-0.1	-0.2	-1.4	-0.7
Fasting Glucose	0.4	0.5	1.7	-0.3	-0.0	0.5	-1.3
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.8	1.3	0.0	0.0	0.0
Blood Eosinophil Count	0.4	3.3	6.8	-0.6	-1.7	1.8	-2.6
Allergy or Eczema	0.4	1.1	3.1	0.1	1.2	1.8	-0.0
Neuroticism	0.4	0.9	3.3	-0.1	0.4	1.8	0.0
Sensitivity / hurt feelings	0.4	0.7	1.6	-0.9	-0.6	1.3	-0.4
Medication for hormone replacement therapy	0.4	0.5	1.2	0.0	-0.3	1.1	-0.8
Serious illness, injury or assault to yourself	0.4	0.5	1.0	1.0	0.5	-0.1	0.9
Medication: Levothyroxine sodium	0.4	0.6	1.6	-0.4	-0.8	-0.1	-1.3
Sitting height	0.4	3.1	9.2	3.0	0.2	1.6	0.8
Heart attack	0.4	0.5	1.3	0.4	1.1	-0.2	0.8
Medication: Ramipril	0.4	0.5	1.5	0.6	1.2	-0.3	0.3
Neuroticism score	0.4	0.9	3.0	0.0	0.8	1.7	0.0
Time employed in main current job	0.4	0.4	1.1	0.7	0.5	-0.1	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	2.0	-0.5	0.4	1.4	-0.3
Impedance of arm (left)	0.4	1.7	4.5	1.3	2.1	0.3	-0.4
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.3	-0.8	-0.2	1.1	0.1
Loud music exposure frequency	0.4	0.4	1.6	-0.1	0.0	-1.3	-0.1
Glaucoma (self-reported)	0.4	0.5	0.6	0.8	0.6	0.5	0.7
Shortness of breath walking on level ground	0.4	0.5	0.9	-0.9	-0.2	1.0	0.2
Medication: Allopurinol	0.4	0.5	0.8	-0.9	-0.1	0.7	-0.9
Medication: Omeprazole	0.4	0.5	1.0	-0.9	-0.2	-1.0	0.1
Heart disease (mother)	0.4	0.4	1.3	0.4	-0.5	0.2	-1.1
Suffer from ‘nerves’	0.4	0.6	1.9	0.2	0.6	1.4	0.1
Average weekly champagne plus white wine intake	0.4	0.6	1.9	0.6	0.1	1.4	-0.0
Miserableness	0.4	0.7	1.7	0.4	1.3	0.9	-0.3
Guilty feelings	0.4	0.6	1.8	-0.3	-0.4	1.3	0.5
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.0	0.3	0.5	-0.6	1.0
Eye problems/disorders: Glaucoma	0.4	0.5	0.9	0.8	0.6	-0.3	1.0
Medication: Blood pressure	0.4	0.7	1.7	-0.8	-0.5	0.6	-1.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.1	-0.4	-1.1	0.4	-0.8
High cholesterol (Self-reported)	0.4	0.7	1.8	0.9	1.4	0.1	0.0
Alcohol drinker status: Never	0.4	0.5	1.3	-0.3	-0.6	-0.5	-1.1
Fractured/broken bones in last 5 years	0.4	0.5	1.1	-0.0	1.0	-0.0	1.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.3	-1.2	-0.0	-0.7	-0.2
Pack years of smoking	0.4	0.6	1.0	-0.9	-0.6	-0.4	-1.0
Depressed Affect (Nagel 2018)	0.3	0.7	1.5	-0.5	-0.9	0.2	-1.2
Neuroticism (Nagel 2018)	0.3	0.6	2.2	-0.1	0.1	1.5	-0.5
Alzheimer’s Disease (including proxy)	0.3	0.4	1.0	0.6	0.5	-0.4	1.0
HDL Cholesterol	0.3	0.5	0.9	0.5	0.9	0.0	0.9
Waist Hip Ratio (WHR)	0.3	1.6	2.9	0.1	1.7	-1.6	0.9
Smoking Status	0.3	0.8	2.1	-0.5	0.7	-1.4	0.6
Chronotype (morning person)	0.3	0.6	1.4	0.2	1.0	-1.2	0.2
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.0	0.3	0.9	1.0	0.2
Medication: Metformin	0.3	0.4	0.8	-0.3	0.2	0.8	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	0.9	0.9	-0.7	0.6	-0.7
Mouth/teeth dental problems	0.3	0.5	0.9	-0.9	0.2	1.0	-0.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.7	-0.5	-0.9	0.2	-0.7
Impedance of arm (right)	0.3	1.2	4.0	0.7	2.0	0.2	-0.6
Falls in the last year	0.3	0.4	0.7	-0.4	-0.7	0.9	-0.6
Hair/balding pattern: Pattern 3	0.3	0.5	1.6	-0.1	-0.1	-0.6	1.3
Lung cancer (father)	0.3	0.3	1.1	-0.3	-0.4	-1.0	-0.2
Birth weight	0.3	0.7	1.9	-1.4	-0.9	0.4	0.1
Number of children fathered	0.3	0.3	0.5	-0.6	-0.4	-0.7	-0.6
Eye problems/disorders: None of the above	0.3	0.4	0.8	-0.2	0.5	-0.9	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.2	1.1	0.1	0.2	0.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.3	1.1	-0.0	0.3	0.4
Back pain experienced in last month	0.3	0.4	1.3	0.1	-0.5	-0.3	1.1
Smoking status: Current	0.3	0.5	1.6	0.1	0.7	-1.3	-0.0
Illnesses of father: High blood pressure	0.3	0.3	0.7	0.8	0.8	-0.1	-0.3
Ever smoked	0.3	0.5	1.6	0.3	1.3	-0.2	0.4
Risk taking	0.3	0.4	0.7	-0.6	-0.4	0.6	-0.9
Pain experienced in last month	0.3	0.5	1.0	1.0	0.9	-0.2	-0.1
Bipolar Disorder or Schizophrenia	0.2	0.4	1.6	-1.3	0.0	0.0	0.0
Crohns Disease (2012)	0.2	0.3	1.0	-1.0	0.0	0.0	0.0
Neuroticism (2016)	0.2	0.2	0.8	-0.9	-0.1	0.2	0.0
Rheumatoid Arthritis	0.2	0.3	1.3	-1.1	0.0	0.0	0.0
Heel T-Score	0.2	1.6	4.2	1.3	-0.8	2.0	0.1
Cardiovascular Disease	0.2	0.8	1.4	-0.8	-0.1	-1.2	-1.0
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.9	0.6	1.0	-0.4	0.5
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	1.0	-0.2	-0.0	0.1	1.0
Supplements: Zinc	0.2	0.3	0.6	0.8	0.1	-0.3	0.6
Diabetes (father)	0.2	0.2	0.7	0.8	0.3	0.2	0.4
Severe depression (siblings)	0.2	0.2	0.5	-0.5	0.2	0.7	0.1
Hand grip strength (right)	0.2	0.5	1.1	0.6	-1.0	0.8	-0.1
Current tobacco smoking	0.2	0.4	1.4	-0.3	0.3	-1.2	0.0
Fed-up feelings	0.2	0.3	0.8	-0.4	0.5	0.9	-0.5
Age when periods started (menarche)	0.2	0.4	0.8	-0.5	-0.6	0.9	-0.2
Stomach or abdominal pain in last month	0.2	0.2	0.7	-0.2	0.0	0.8	-0.4
Past tobacco smoking	0.2	0.4	0.9	-0.0	-1.0	0.6	-0.2
Diabetes (self-reported)	0.2	0.3	0.8	-0.9	0.3	0.1	-0.6
Worrier / anxious feelings	0.2	0.3	1.1	0.0	1.0	0.5	0.2
Noisy workplace	0.2	0.2	0.4	-0.7	-0.3	-0.1	-0.5
Medication: Cholesterol lowering	0.2	0.4	0.5	0.1	0.7	-0.7	-0.7
Illnesses of mother	0.2	0.3	0.9	0.3	1.0	0.4	0.2
Hair/balding pattern: Pattern 4	0.2	0.4	0.9	-0.5	0.3	-1.0	0.5
Medication: Amlodipine	0.2	0.3	0.7	-0.8	-0.5	-0.0	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.9	-0.0	0.0	0.9	-0.5
Number of full sisters	0.2	0.2	0.6	-0.4	0.1	-0.8	-0.1
Loneliness, isolation	0.2	0.3	0.6	-0.2	-0.4	0.6	-0.8
Diabetes diagnosed by doctor	0.2	0.3	0.7	-0.6	0.8	0.3	-0.3
Osteoporosis (self-reported)	0.2	0.3	0.6	-0.6	-0.8	0.5	0.1
Wears glasses or contact lenses	0.2	0.2	0.6	-0.0	-0.0	-0.8	0.4
Bipolar Disorder (2018)	0.1	0.1	0.5	0.7	0.0	0.0	0.0
Age at First Birth	0.1	0.2	0.5	0.7	0.0	0.5	-0.1
Mean Putamen Volume	0.1	0.1	0.2	0.0	-0.4	0.3	0.0
Lupus	0.1	0.2	0.5	0.1	-0.7	0.5	0.3
Blood Platelet Count	0.1	1.4	2.6	-1.6	0.3	-0.9	-1.4
Height	0.1	1.7	3.2	1.8	0.4	1.1	1.5
Systolic Blood Pressure	0.1	0.4	0.9	-0.1	0.1	-0.7	-1.0
Hand grip strength (left)	0.1	0.4	1.0	0.6	-1.0	0.3	0.2
Angina	0.1	0.2	0.4	-0.6	-0.3	-0.1	0.3
Pack years adult smoking proportion	0.1	0.2	0.4	-0.4	-0.2	-0.6	-0.3
Nervous feelings	0.1	0.1	0.2	0.3	0.4	0.2	-0.4
Had other major operations	0.1	0.1	0.2	0.2	0.4	0.3	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	0.2	-0.6	0.2	-0.5
Standing height	0.1	0.5	0.9	1.0	-0.4	0.8	0.5
Angina (self-reported)	0.1	0.1	0.2	-0.5	-0.2	0.0	0.1
Pulse rate, automated reading	0.1	0.2	0.5	-0.0	0.3	0.7	0.5
Overall health rating	0.1	0.3	0.9	-1.0	-0.2	-0.4	0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	-0.2	-0.0	-0.5	-0.5
Medication: Aspirin	0.1	0.2	0.4	-0.0	0.6	0.1	-0.5
Smoking status: Previous	0.1	0.2	0.4	0.1	0.6	-0.2	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	-0.3	-0.3	0.1	0.7
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.3	-0.3	0.2	0.5	0.5
Medication: Aspirin	0.1	0.2	0.7	0.1	0.8	-0.2	-0.0
Number of operations (self-reported)	0.1	0.2	0.5	-0.4	-0.3	0.7	-0.2
Commuting to job workplace: Cycle	0.1	0.1	0.3	0.1	-0.2	-0.2	-0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.1	-0.3	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.2	0.4	0.0	0.0	0.0
Hair Pigment	0.0	0.2	0.4	0.6	-0.5	0.1	-0.5
Tanning	0.0	0.4	0.7	-0.6	-0.1	-0.8	-0.6
Medication: Co-codamol	0.0	0.0	0.1	-0.3	0.0	0.1	-0.1
Had menopause	0.0	0.0	0.0	0.0	-0.1	0.1	0.0
Pulse rate	0.0	0.1	0.1	-0.4	0.2	-0.2	0.1
Average weekly red wine intake	0.0	0.1	0.1	0.3	0.2	0.2	0.2
Medication: Bendroflumethiazide	0.0	0.0	0.1	0.0	-0.3	-0.3	0.0

Hub : Genes

RSPH10B2

Models

Trait associations