Hub : Genes

C11orf17

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.0440	0.0380	4.2e-03	0.010	0.026	0.052	NA	0.025	4.4e-02	2.6e-03	3.3e-05	NA	2.9e-03
2	TCGA	Breast Invasive Carcinoma	0.0127	0.0100	5.3e-03	0.009	0.012	0.004	NA	0.010	4.0e-03	1.5e-03	3.8e-02	NA	3.4e-03
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.3522	0.1440	2.3e-07	0.051	0.067	0.068	NA	0.063	2.0e-06	5.6e-08	3.9e-08	NA	1.3e-07
4	TCGA	Brain Lower Grade Glioma	0.0979	0.0443	5.6e-07	0.029	0.053	0.050	NA	0.054	2.7e-04	1.1e-06	2.4e-06	NA	9.2e-07
5	TCGA	Lung Adenocarcinoma	0.0857	0.0537	9.1e-03	0.021	0.009	0.010	NA	0.012	1.5e-03	3.0e-02	2.3e-02	NA	1.3e-02
6	TCGA	Lung Squamous Cell Carcinoma	0.0252	0.0188	9.0e-03	0.025	0.012	0.001	NA	0.018	7.1e-04	1.3e-02	2.4e-01	NA	3.4e-03
7	TCGA	Testicular Germ Cell Tumors	0.1050	0.0780	2.3e-03	0.057	0.085	0.073	NA	0.050	4.7e-03	6.5e-04	1.5e-03	NA	7.4e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.4	0.6	1.5	-1.2	-0.6	-0.7	-0.9	-0.0	-0.5	-0.9
Bipolar Disorder or Schizophrenia	0.4	1.0	2.8	-1.7	-1.1	-0.1	-0.6	0.1	0.7	-1.5
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	-0.2	-0.4	-0.1	-0.4	-0.5	0.3	-0.6
Depression (Nagel 2018)	0.1	0.1	0.2	0.2	0.5	-0.0	0.2	-0.0	0.3	0.5
Intelligence (Savage-Jansen 2018)	0.8	2.6	3.8	-2.0	-1.9	-0.3	-1.6	-1.9	1.3	-1.7
Neuroticism (Nagel 2018)	2.1	5.0	13.3	-1.0	-2.5	1.9	-0.9	-2.3	3.7	-2.2
Schizophrenia (2018)	0.4	0.8	1.8	-1.2	-0.9	0.4	0.0	0.2	1.3	-1.2
Schizophrenia vs Biploar Disorder	0.2	0.3	1.1	-0.7	-0.3	1.0	-0.1	0.4	0.5	-0.4
Worry (Nagel 2018)	2.9	6.0	16.8	-1.4	-2.7	1.1	-1.3	-2.9	4.1	-2.1
Alzheimer’s Disease (in mother)	1.6	1.9	4.1	-1.0	-1.6	-0.2	-1.7	-2.0	0.9	-1.4
Alzheimer’s Disease (in father)	0.2	0.2	0.6	-0.6	0.0	-0.6	0.1	-0.0	0.8	-0.1
Alzheimer’s Disease (including proxy)	0.6	0.8	3.7	-0.3	-0.4	-1.9	-0.5	-1.0	0.6	-0.2
Crohns Disease (2017)	0.6	1.3	3.7	-1.8	-1.0	0.5	-0.3	-0.6	1.9	-0.6
Irritable Bowel Disease (IBD)	1.6	3.9	7.7	-2.8	-2.4	0.8	-1.0	-1.2	2.7	-1.9
Ulcerative Colitis (UC)	2.2	4.1	7.7	-2.8	-2.7	0.5	-1.4	-1.3	2.0	-2.3
Major Depression (MDD)	1.1	1.3	2.2	-0.9	-1.2	-1.1	-1.5	-1.4	0.9	-0.9
Reaction Time	2.2	4.2	7.9	-0.3	-2.2	1.8	-1.9	-2.8	1.6	-2.7
Verbal and Numeric Reasoning (VNR)	1.8	4.4	7.3	-2.7	-2.3	-1.1	-2.1	-2.3	2.0	-1.8
Breast Cancer	0.3	0.7	2.0	0.9	-0.1	1.0	0.5	-0.9	1.4	-0.2
Ovarian Cancer	0.7	0.9	3.4	-0.3	0.6	-1.2	-0.0	0.7	-1.8	0.7
Prostate Cancer	0.8	1.2	2.5	-0.3	1.0	-1.4	0.2	1.0	-1.6	1.3
Age at First Birth	0.4	0.5	1.2	1.1	0.7	0.6	0.9	0.7	0.2	0.6
Bipolar Disorder (2011)	1.0	0.9	2.7	-0.3	-0.6	1.3	-0.2	-0.5	1.6	-1.1
Body Mass Index (BMI) (2010)	0.2	0.3	0.7	0.5	0.7	-0.2	0.1	0.2	-0.8	0.8
Coronary Artery Disease (CAD)	0.5	0.6	1.7	0.3	0.7	0.1	1.2	1.3	0.1	0.4
Crohns Disease (2012)	0.8	1.3	4.8	-1.8	-0.7	0.1	-0.2	-0.7	2.2	-0.0
Mean Putamen Volume	2.7	3.0	5.4	1.4	1.7	-2.2	1.5	1.2	-1.6	2.3
Fasting Glucose	1.2	1.5	3.1	1.1	1.3	-1.5	0.5	0.8	-1.8	1.1
HbA1C	1.7	1.8	5.4	-0.8	1.0	-2.3	-0.1	1.0	-2.0	0.9
HDL Cholesterol	0.1	0.2	0.5	0.3	-0.3	-0.3	-0.7	-0.5	-0.3	-0.7
LDL Cholesterol	0.5	0.8	3.3	-0.1	0.6	-1.1	-0.2	0.8	-1.8	0.5
Lupus	2.0	3.0	6.2	-0.7	-1.9	1.8	-0.7	-1.3	2.3	-2.5
Neuroticism (2016)	2.8	4.1	6.6	-2.4	-2.6	-1.1	-1.9	-2.1	2.0	-1.7
Primary Biliary Cirrhosis	0.4	0.5	0.9	0.7	0.8	-0.8	0.9	0.9	0.1	0.6
Rheumatoid Arthritis	0.3	0.4	0.8	-0.7	-0.7	0.6	-0.2	-0.3	0.9	-0.7
Schizophrenia (2014)	0.5	1.0	2.5	-1.6	-1.0	0.3	-0.2	0.2	1.3	-1.4
Triglycerides	0.1	0.2	1.1	-0.1	0.0	1.0	0.2	0.1	0.1	-0.1
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	-0.2	0.1	0.3	0.7	0.5	0.6	-0.0
Ulcerative Colitis	1.7	2.4	6.4	-1.3	-2.0	1.3	-0.3	-0.8	2.5	-1.7
Blood Eosinophil Count	0.3	2.0	8.1	1.5	1.6	-0.7	-0.2	0.4	-2.8	0.7
Blood Platelet Count	6.4	74.1	193.2	4.0	8.9	-10.5	1.8	5.2	-13.9	9.4
Blood Red Count	3.0	29.0	114.5	2.3	5.3	-5.7	-0.8	2.3	-10.7	4.0
Blood White Count	0.9	6.8	26.3	-0.3	1.7	-3.6	-1.9	-0.1	-5.1	1.3
Heel T-Score	4.7	37.6	59.3	7.6	3.6	7.7	7.7	3.1	7.4	3.1
BMI	0.0	0.2	0.6	0.8	0.4	0.4	0.2	0.0	-0.1	-0.6
Height	0.4	8.6	15.8	-3.2	-4.0	-0.0	-2.0	-2.3	3.3	-3.8
Waist Hip Ratio (WHR)	2.5	11.3	20.2	-2.9	-3.7	1.1	-2.9	-3.4	4.5	-4.0
Systolic Blood Pressure	0.8	4.0	10.1	0.9	1.2	3.2	2.4	2.0	2.1	1.4
Smoking Status	0.3	0.7	1.8	-0.2	0.8	-0.8	0.6	1.1	-0.4	1.3
Allergy or Eczema	3.0	7.9	13.0	-1.1	-3.0	2.1	-2.2	-3.6	3.5	-3.2
Cardiovascular Disease	0.2	0.5	1.2	-0.7	0.4	0.4	0.9	1.1	0.7	0.8
Hypothyroidism (self reported)	0.3	0.7	1.9	-0.8	-0.2	-1.4	-1.0	-0.8	-1.0	0.3
Respiratory disease	3.4	7.5	12.9	-3.3	-2.8	-1.3	-3.6	-3.5	0.8	-2.5
Type 2 Diabetes (T2D) (2018)	2.2	4.1	6.2	-1.6	-2.4	1.0	-2.4	-2.4	1.3	-2.5
Lung FEV1/FVC ratio	4.3	21.6	41.7	4.5	4.4	4.2	6.4	6.5	0.5	3.3
Lung FVC	0.4	2.3	4.3	1.2	1.8	-0.7	1.3	1.4	-1.6	2.1
Neuroticism	1.9	4.5	11.4	-1.1	-2.5	0.4	-1.3	-2.7	3.4	-1.9
Chronotype (morning person)	0.3	0.6	2.1	0.8	0.3	1.4	0.7	0.8	0.2	-0.3
Hair Pigment	0.1	1.5	4.9	-2.2	-0.8	-1.6	-1.3	-0.8	0.1	-0.0
Tanning	0.5	5.5	13.0	2.1	2.7	-1.4	1.1	1.7	-3.6	2.8
Hand grip strength (left)	0.9	2.4	3.9	2.0	1.5	1.0	1.8	1.9	-1.2	1.1
Number of treatments/medications taken	1.3	2.3	4.9	-2.2	-1.7	-0.9	-2.0	-1.5	0.4	-1.2
Average weekly spirits intake	0.2	0.2	0.4	-0.3	0.1	0.2	0.6	0.4	0.6	0.5
Sensitivity / hurt feelings	0.7	1.2	4.8	0.6	-0.8	1.2	0.5	-0.9	2.2	-0.6
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.7	-0.1	0.2	0.6	-0.1	-0.1	0.8	0.4
Hearing difficulty/problems: Yes	1.5	2.3	6.3	0.1	1.6	-1.2	1.6	2.5	-1.2	1.4
Relative age of first facial hair	0.8	1.7	3.5	1.4	1.2	0.7	1.9	1.5	0.2	1.5
Other serious medical condition/disability diagnosed by doctor	2.5	3.3	7.0	-2.2	-2.1	0.6	-1.1	-1.4	2.6	-1.8
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.5	-0.6	-0.6	-0.6	-0.5	-0.4	-0.1	-0.7
Ever had hysterectomy (womb removed)	0.9	1.0	2.8	0.4	1.1	-1.2	0.2	0.8	-1.7	0.9
Systolic blood pressure, automated reading	1.1	3.3	5.5	1.7	2.0	1.7	2.4	1.9	0.5	2.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.4	-0.1	-0.3	0.9	-1.0	-1.2	0.0	-0.6
Angina	1.2	1.6	3.2	-1.5	-0.8	-1.8	-1.7	-1.6	0.1	-0.3
Medication for hormone replacement therapy	0.4	0.5	1.2	-1.1	-0.6	-0.5	-1.1	-0.5	0.0	-0.4
Vitamin and mineral supplements	1.4	1.9	3.8	0.6	1.6	-0.2	1.8	1.9	0.0	1.9
Supplements: Zinc	0.6	0.7	1.7	-0.5	-0.5	-0.4	-1.3	-0.3	-0.9	-1.2
Medication: Co-codamol	0.5	0.6	2.2	-1.0	-0.2	-1.5	-0.7	-0.1	-0.8	0.2
Medication: Metformin	0.3	0.4	0.7	0.4	-0.7	0.8	-0.2	-0.8	0.7	-0.7
Diabetes (father)	0.9	1.1	2.9	-1.1	-1.4	0.5	-0.9	-0.6	0.5	-1.7
Diabetes (mother)	1.8	2.2	7.3	-0.9	-1.2	1.8	-0.2	-0.4	2.7	-1.6
Severe depression (siblings)	0.2	0.2	1.1	-0.3	0.1	-1.1	-0.2	-0.2	-0.3	0.3
Pack years adult smoking proportion	0.2	0.3	1.2	-0.6	-0.5	-0.4	-0.2	-0.5	1.1	0.3
Impedance of leg (right)	2.5	12.2	19.3	-3.5	-4.3	0.4	-4.1	-4.4	2.4	-3.7
Leg fat-free mass (left)	0.2	0.8	2.5	0.6	0.9	0.3	1.3	1.6	-0.4	0.3
Trunk fat percentage	0.5	2.0	4.5	-0.9	-1.5	0.5	-1.5	-1.7	1.1	-2.1
Hand grip strength (right)	0.7	2.0	3.5	1.3	1.5	0.2	1.4	1.8	-1.9	1.2
Townsend deprivation index at recruitment	1.9	2.6	6.0	-0.2	1.6	-1.3	1.3	2.4	-1.6	2.0
Current tobacco smoking	0.6	1.0	2.4	0.1	0.9	-1.0	1.0	1.3	-0.5	1.5
Average weekly fortified wine intake	0.4	0.5	1.3	1.1	0.7	0.3	0.2	0.0	-0.9	0.7
Maternal smoking around birth	0.3	0.5	1.0	-0.4	0.6	-0.8	0.4	1.0	-0.6	0.8
Fed-up feelings	0.9	1.6	2.5	0.4	1.2	-1.6	1.2	1.6	-1.0	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.1	-0.1	0.7	-0.9	0.3	0.5	-0.5	1.0
Relative age voice broke	0.1	0.1	0.6	-0.3	-0.0	-0.0	-0.2	0.3	-0.7	0.2
Taking other prescription medications	2.8	4.3	7.4	-2.7	-2.3	-1.2	-2.7	-2.3	0.3	-1.9
Age when periods started (menarche)	0.8	1.8	6.4	0.4	0.8	-1.0	0.8	1.8	-2.5	0.8
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.1	-0.3	0.0	-0.5	-0.2	-0.5	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.3	13.5	0.8	-0.2	2.5	1.7	0.5	3.7	-0.3
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.2	0.2	-1.0	1.2	-0.4	-0.8	1.5	-1.4
Qualifications: CSEs or equivalent	2.7	3.6	5.5	1.8	2.3	-0.4	2.0	2.2	-1.6	2.3
Serious illness, injury or assault to yourself	0.3	0.4	2.0	-0.3	0.2	-1.4	-0.1	-0.1	-0.3	0.5
High blood pressure	0.5	1.4	4.3	-0.4	0.1	1.3	1.5	1.1	2.1	0.7
Hayfever, allergic rhinitis or eczema	2.6	5.6	8.3	-1.1	-2.7	1.7	-1.8	-2.8	2.9	-2.9
Multivitamins +/- minerals	1.6	2.0	3.9	-0.4	-1.6	0.5	-1.7	-2.0	0.6	-1.9
Stomach or abdominal pain in last month	7.3	9.1	14.8	-3.9	-3.6	0.1	-2.7	-3.0	3.1	-3.1
Supplements: Glucosamine	0.1	0.2	0.4	-0.2	-0.2	0.1	-0.6	-0.3	-0.3	-0.6
Diverticular disease/diverticulitis (self-reported)	1.9	2.3	4.5	-1.6	-1.8	-0.8	-0.9	-1.5	2.1	-1.4
Medication: Atenolol	2.1	2.6	5.3	0.8	1.8	-2.0	0.9	1.2	-1.8	2.3
Medication: Levothyroxine sodium	1.3	2.3	7.7	-0.6	0.9	-2.8	-0.4	0.2	-2.0	1.7
Sitting height	0.1	0.6	1.1	-0.8	-1.0	-0.9	-0.4	-0.8	0.7	-0.7
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	-0.2	-0.4	-0.6	-0.2	-0.4	0.7	0.1
High blood pressure (mother)	0.9	1.2	2.6	-1.5	-1.2	0.4	-0.8	-0.8	1.6	-0.9
Body mass index (BMI)	0.1	0.3	0.6	0.5	0.7	0.3	0.5	0.7	-0.5	-0.3
Impedance of leg (left)	2.6	12.6	20.6	-3.6	-4.3	-0.2	-4.4	-4.5	2.0	-3.7
Leg predicted mass (left)	0.1	0.7	2.3	0.6	0.8	0.4	1.3	1.5	-0.3	0.2
Trunk fat mass	0.4	1.6	4.3	-0.8	-1.3	0.5	-1.2	-1.3	0.9	-2.1
Waist circumference	0.3	1.3	3.2	-1.2	-1.0	-0.4	-1.4	-1.0	0.2	-1.8
Number of incorrect matches in round	2.2	3.7	10.6	-0.1	-1.6	3.2	0.0	-0.5	2.6	-2.4
Past tobacco smoking	0.1	0.2	0.7	0.3	0.1	0.8	0.6	0.6	0.2	-0.4
Alcohol usually taken with meals	0.9	1.5	3.4	-0.8	-1.3	0.3	-1.5	-1.4	0.0	-1.8
Nervous feelings	2.1	3.9	12.4	-1.7	-2.2	0.2	-1.0	-2.0	3.5	-1.5
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	5.7	-0.6	-1.4	0.4	-0.8	-1.9	2.4	-0.9
Hearing difficulty/problems with background noise	0.7	1.2	3.4	0.1	1.2	-0.3	1.2	1.8	-0.6	1.1
Hair/balding pattern: Pattern 2	3.4	4.3	6.5	-1.6	-2.4	1.5	-2.4	-2.4	1.3	-2.5
Had menopause	0.1	0.2	0.9	-0.2	0.0	-0.4	0.1	-0.1	1.0	0.1
Had other major operations	0.3	0.4	1.7	-0.3	0.4	-0.3	-0.7	0.1	-1.3	-0.0
Forced vital capacity (FVC)	0.1	0.3	0.6	-0.5	0.3	-0.5	0.3	0.8	-0.6	0.5
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	11.4	1.2	-0.2	2.4	1.5	-0.1	3.4	-0.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.2	-1.1	-0.6	-1.5	-0.7	-0.7	0.5	-0.1
Qualifications: None of the above	0.3	0.6	1.7	0.0	0.9	-0.5	0.7	1.3	-0.7	0.7
Financial difficulties in last 2 years	0.8	1.1	3.5	1.9	0.7	1.1	1.2	0.8	-0.3	0.2
Mouth/teeth dental problems	0.6	0.8	1.8	1.3	0.8	0.2	1.2	0.6	0.4	1.2
Heart attack	1.0	1.3	3.0	-0.5	1.1	-1.7	0.2	1.0	-1.4	1.1
Allergy	3.5	8.0	14.4	2.3	3.2	-0.3	3.2	3.8	-2.4	3.2
Pain all over the body in last month	0.0	0.1	0.2	-0.5	-0.0	-0.1	0.1	0.2	0.2	0.0
Diabetes (self-reported)	1.0	1.5	3.0	-0.7	-1.3	0.6	-1.5	-1.7	0.8	-1.4
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	6.1	-0.5	-1.9	1.2	-1.2	-1.7	1.4	-2.5
Medication: Ramipril	3.8	4.8	7.9	1.8	2.5	-0.3	2.5	2.8	-1.6	2.8
Medication: Simvastatin	0.1	0.1	0.3	-0.2	-0.1	-0.6	-0.4	-0.5	-0.2	-0.0
Fluid intelligence score	2.1	4.4	6.3	-2.5	-2.4	-0.4	-2.4	-2.5	1.5	-2.1
Illnesses of siblings	0.8	1.1	4.5	0.8	0.8	-1.0	0.0	0.3	-2.1	0.9
Neuroticism score	2.5	5.2	13.1	-1.5	-2.6	0.1	-1.5	-2.9	3.6	-1.9
Weight	0.0	0.2	1.1	-0.3	-0.2	0.1	-0.1	0.2	0.0	-1.1
Impedance of arm (right)	1.0	4.7	9.1	-1.1	-2.7	1.0	-2.0	-3.0	2.3	-2.2
Arm fat percentage (right)	0.2	0.7	1.9	0.6	-0.3	1.1	-0.3	-0.7	0.7	-1.4
Trunk fat-free mass	0.1	0.7	2.3	0.3	0.8	-0.1	0.9	1.5	-0.9	0.3
Hip circumference	0.2	1.0	4.2	-0.4	0.8	-1.2	-0.1	0.8	-2.0	0.2
Time employed in main current job	0.9	1.0	3.3	-0.1	-1.1	0.0	-0.3	-1.4	1.8	-0.8
Alcohol intake versus 10 years previously	1.2	1.8	4.2	0.1	1.6	-0.9	0.7	1.5	-2.0	1.5
Father’s age at death	1.3	1.7	3.8	-0.3	-1.5	0.2	-1.4	-1.9	1.0	-1.8
Worrier / anxious feelings	2.3	4.4	9.4	-1.5	-2.5	0.3	-1.5	-2.7	3.1	-1.7
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	4.5	-2.1	-1.9	-0.8	-1.9	-2.1	1.6	-1.5
Falls in the last year	1.7	2.3	4.7	-2.2	-1.8	-0.1	-1.3	-1.1	1.4	-1.7
Hair/balding pattern: Pattern 3	3.3	5.0	7.1	1.5	2.6	-1.8	1.9	2.4	-2.5	2.7
Number of live births	0.4	0.6	1.6	-1.3	-0.4	-0.6	-1.1	-0.2	-0.5	-0.6
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	5.0	0.6	1.2	0.8	1.8	2.2	-0.0	1.0
Pulse rate	0.4	0.6	1.3	0.0	-1.1	0.6	-0.2	-0.8	0.8	-1.1
Happiness	0.4	0.5	1.2	-0.3	-0.6	0.5	-0.6	-0.7	1.1	-1.0
Noisy workplace	0.0	0.0	0.1	-0.3	-0.2	0.1	0.0	0.4	-0.0	-0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.1	-0.6	-0.5	-1.0	-0.3	-0.3	0.0	-0.4
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.4	-1.0	-1.3	0.7	-1.0	-0.7	0.9	-1.5
Mouth/teeth dental problems: Dentures	0.4	0.7	1.7	-0.4	-0.1	-1.3	-1.1	-0.5	-1.2	-0.1
Asthma	1.8	3.6	7.0	-2.4	-1.7	-1.4	-2.6	-2.2	-0.0	-1.6
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	3.5	0.9	1.4	-0.3	1.6	1.9	-0.4	1.2
Medication: Cholesterol lowering	0.1	0.2	0.8	0.5	-0.0	0.2	0.2	-0.5	0.9	0.1
Depression (self-reported)	0.6	0.8	3.2	-0.7	-0.9	-0.1	-0.2	-0.7	1.8	-0.6
Medication: Lansoprazole	1.9	2.2	3.5	-1.8	-1.8	-0.1	-1.4	-1.6	1.9	-1.0
Prospective memory result	0.1	0.2	0.6	-0.8	0.2	-0.3	-0.1	0.4	-0.1	0.5
Lung cancer (father)	0.0	0.0	0.1	0.1	-0.3	0.0	-0.1	-0.1	-0.3	0.1
Illnesses of mother	3.6	4.4	7.3	1.9	2.5	-1.3	1.5	1.9	-2.7	2.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	6.9	1.0	1.6	1.4	2.5	2.6	0.6	1.6
Pulse wave Arterial Stiffness index	0.9	1.1	3.8	-0.8	-0.4	-1.9	-0.9	-1.3	0.1	0.5
Impedance of arm (left)	0.6	2.6	6.1	-0.8	-1.9	0.5	-1.5	-2.5	1.9	-1.2
Arm fat mass (right)	0.1	0.4	2.1	0.1	-0.3	0.8	-0.3	-0.3	0.3	-1.4
Trunk predicted mass	0.1	0.6	2.2	0.3	0.8	-0.1	0.9	1.5	-0.8	0.2
Standing height	0.2	2.1	4.2	-1.8	-2.1	-0.2	-1.2	-1.1	1.2	-1.8
Length of working week for main job	0.2	0.3	0.6	0.4	-0.0	0.8	0.2	0.5	-0.3	-0.8
Exposure to tobacco smoke at home	0.8	0.9	3.1	-0.6	-0.9	1.1	-0.9	-0.1	-0.1	-1.8
Breastfed as a baby	0.1	0.1	0.3	-0.6	0.1	0.1	-0.1	0.5	0.4	0.2
Tense / ‘highly strung’	2.2	3.6	10.4	-1.5	-2.2	0.9	-1.1	-1.8	3.2	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	4.3	-1.9	-1.9	-1.3	-1.5	-2.1	1.9	-1.0
Hair/balding pattern: Pattern 4	0.9	2.3	5.0	-1.1	-1.7	1.0	-0.8	-1.0	2.1	-2.2
Birth weight of first child	0.5	0.9	2.6	0.0	-0.1	1.6	0.7	0.5	1.6	-0.4
Peak expiratory flow (PEF)	1.6	3.6	9.1	1.4	2.3	0.7	2.4	3.0	-0.7	1.5
Pulse wave reflection index	1.2	1.5	5.7	-1.1	0.4	-2.4	-0.8	-0.1	-1.4	1.1
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.1	-0.7	0.0	-1.4	-0.7	-0.2	-0.8	0.3
Loud music exposure frequency	0.6	0.7	1.8	1.3	0.8	-0.3	0.9	0.4	0.1	1.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.3	0.1	-0.5	0.4	-0.2	-0.6	-0.1	-0.4
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	4.8	-0.3	-0.4	2.2	0.4	0.2	1.6	-0.8
Blood clot in the leg (DVT)	0.2	0.2	0.4	-0.1	-0.3	0.6	-0.4	-0.5	0.6	-0.5
Medication: Paracetamol	0.1	0.1	0.4	-0.6	-0.0	-0.1	-0.2	0.4	0.1	0.2
Headache pain in last month	0.2	0.4	1.5	-0.8	-0.5	-1.2	-0.1	0.4	-0.5	-0.2
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.5	-0.7	-0.3	-0.0	-0.6	0.1	-0.7	-0.7
Glaucoma (self-reported)	1.0	1.2	6.3	-0.6	-0.5	1.0	0.4	0.2	2.5	-0.7
Gout (self-reported)	1.0	1.4	3.5	1.2	1.5	-0.4	0.5	0.6	-1.3	1.9
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	3.3	-1.0	0.0	-1.8	-0.8	-0.3	-1.2	0.6
Medication: Amlodipine	1.0	1.5	6.2	-0.4	-0.9	1.6	0.3	-0.4	2.5	-0.4
Medication: Ventolin 100micrograms inhaler	4.7	6.0	10.2	-3.2	-2.8	-0.8	-2.9	-2.4	1.2	-2.8
Birth weight	0.3	0.7	1.8	-0.4	-1.0	1.1	-0.2	-0.1	0.9	-1.4
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	0.1	-0.4	0.4	-0.6	-0.6	0.1	-0.5
High blood pressure (siblings)	0.4	0.6	3.3	-0.6	0.0	-0.2	0.6	0.6	1.8	0.2
Forced vital capacity (FVC), Best measure	0.2	0.8	1.9	-0.1	0.5	0.8	1.2	1.4	0.7	0.6
Body fat percentage	0.6	2.2	5.2	-0.9	-1.5	0.7	-1.5	-1.8	1.1	-2.3
Leg fat percentage (right)	0.6	2.2	4.8	-1.1	-1.4	0.7	-1.6	-1.7	1.1	-2.2
Arm fat-free mass (right)	0.1	0.4	1.3	-0.2	0.5	-0.4	0.5	1.1	-0.7	-0.1
Exposure to tobacco smoke outside home	0.4	0.5	2.2	0.1	-0.5	1.5	-0.1	-0.3	0.8	-0.8
Comparative body size at age 10	0.3	0.8	2.6	1.6	0.8	0.8	0.9	0.5	0.7	0.0
Number of full brothers	0.9	1.2	2.4	0.9	1.5	-0.4	1.2	1.2	-0.6	1.4
Worry too long after embarrassment	2.9	4.9	14.6	0.1	-2.2	1.3	-0.8	-3.1	3.8	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	2.5	3.3	9.1	-2.3	-2.0	-0.2	-0.8	-1.2	3.0	-1.6
Wheeze or whistling in the chest in last year	2.6	4.6	8.8	-2.4	-2.6	1.3	-2.0	-1.6	1.5	-3.0
Number of children fathered	0.3	0.4	1.1	0.1	-0.2	-0.2	-1.1	-0.9	-0.6	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	4.2	2.1	0.8	0.6	0.8	0.3	0.0	0.5
Age at first live birth	0.8	1.4	4.5	0.2	-1.3	0.4	-1.2	-2.1	0.7	-1.2
Pulse wave peak to peak time	0.7	0.9	3.3	0.6	0.2	1.8	0.8	1.1	-0.0	-0.6
Health satisfaction	3.7	4.8	7.3	-2.5	-2.7	0.7	-2.0	-2.1	2.2	-2.6
Shortness of breath walking on level ground	5.0	5.9	9.3	-2.6	-3.1	-0.3	-2.4	-2.8	2.2	-2.6
Qualifications: College or University degree	0.7	2.1	4.1	-0.5	-1.7	1.1	-0.8	-1.4	2.0	-2.0
Eye problems/disorders: None of the above	2.9	3.3	5.7	0.8	2.0	-0.7	1.4	2.3	-2.4	2.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.6	-0.7	-0.4	0.7	-0.8	-0.4	0.5	-0.8
Emphysema/chronic bronchitis	4.4	4.9	7.8	-2.6	-2.2	-2.8	-2.5	-2.5	0.6	-1.4
Medication for pain relief, constipation, heartburn	0.3	0.5	2.2	1.5	0.5	0.8	0.4	-0.4	-0.2	0.4
Neck or shoulder pain in last month	0.0	0.0	0.2	-0.4	-0.1	0.0	-0.1	0.3	-0.1	-0.1
Medication: Blood pressure	0.6	1.0	2.2	1.1	0.9	-0.1	1.5	0.6	0.8	1.5
Angina (self-reported)	1.3	1.7	4.2	-1.4	-0.7	-2.0	-1.7	-1.6	-0.1	-0.1
Migraine (self-reported)	1.1	1.4	4.2	-1.9	-0.9	-2.1	-0.9	-0.6	0.1	-0.2
Medication: Ibuprofen	0.4	0.4	0.9	0.7	0.6	0.2	1.0	0.9	0.2	0.5
Medication: Allopurinol	1.5	2.0	4.4	1.9	1.8	0.4	1.0	0.9	-1.0	2.1
Medication: Omeprazole	2.1	2.5	6.8	-2.6	-1.7	-0.6	-1.8	-1.1	0.5	-1.6
Medication: Seretide 50 evohaler	0.1	0.2	0.5	0.3	0.3	-0.1	0.7	0.5	-0.1	0.2
Mean time to correctly identify matches	1.5	2.8	6.2	-0.0	-1.7	1.4	-1.5	-2.5	1.5	-2.0
Heart disease (mother)	2.0	2.5	4.5	-1.1	-1.7	1.3	-0.9	-1.4	2.1	-2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	5.3	0.7	1.2	-0.4	0.3	1.1	-2.3	1.0
Whole body fat mass	0.3	1.3	4.2	-0.7	-1.1	0.7	-1.1	-1.1	0.7	-2.1
Leg fat mass (right)	0.4	1.7	4.7	-1.1	-1.3	0.4	-1.4	-1.2	0.7	-2.2
Arm predicted mass (right)	0.0	0.2	0.6	-0.6	-0.0	-0.4	0.1	0.8	-0.5	-0.6
Pulse rate, automated reading	1.2	3.8	6.7	-1.4	-2.3	0.4	-1.8	-2.6	2.0	-2.2
Alcohol intake frequency.	0.5	1.2	4.7	-2.2	-1.1	-0.6	-0.9	-0.0	0.2	-1.0
Comparative height size at age 10	0.3	1.5	3.1	-1.0	-1.1	-1.0	-1.8	-1.4	-0.7	-1.3
Number of full sisters	0.7	0.9	2.5	-1.4	0.3	-1.6	0.1	1.1	-0.4	0.2
Suffer from ‘nerves’	1.5	2.4	5.4	-1.3	-1.8	-0.0	-1.1	-1.9	2.3	-1.3
Overall health rating	2.7	5.7	14.7	-3.8	-2.6	-1.5	-2.4	-2.0	1.6	-2.0
Chest pain or discomfort	2.5	3.6	6.7	-2.6	-2.4	-0.5	-1.7	-1.7	1.6	-2.2
Had major operations	2.8	3.3	8.0	-0.7	-1.9	0.3	-2.0	-2.8	1.6	-2.1
Age at last live birth	0.4	0.6	2.0	0.6	-0.6	0.5	-0.6	-1.4	0.4	-0.7
Family relationship satisfaction	1.0	1.2	3.3	1.3	0.7	1.8	1.1	1.4	0.1	-0.1
Leg pain on walking	0.5	0.6	1.0	-1.0	-0.7	-0.7	-0.9	-0.8	0.9	-0.3
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	2.9	-0.5	-1.4	0.9	-1.4	-1.7	0.2	-1.5
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.6	0.5	0.5	1.2	1.2	0.5	1.6	0.7
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	-0.6	-0.1	-0.1	-0.2	0.2	-0.4	-0.0
Medication: Aspirin	0.9	1.2	1.8	-1.3	-1.3	-0.4	-1.0	-1.1	1.1	-1.4
Supplements: Vitamin C	0.1	0.2	0.5	-0.3	0.0	-0.6	-0.3	0.3	-0.7	-0.2
Knee pain experienced in last month	0.2	0.3	0.7	0.2	0.6	0.2	0.8	0.8	-0.5	0.6
Hypertension (Self-reported)	0.5	1.3	4.0	-0.4	0.2	1.1	1.4	1.1	2.0	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	4.4	-1.5	-0.7	-2.1	-1.1	-0.8	-0.6	-0.5
Illnesses of father: Heart disease	2.7	3.7	7.5	-1.6	-2.3	0.4	-2.3	-2.3	0.3	-2.7
Illnesses of siblings: Diabetes	2.1	2.6	4.8	-1.4	-1.8	0.1	-1.7	-2.2	1.8	-1.5
Smoking status: Previous	0.2	0.3	0.6	-0.3	-0.0	-0.8	-0.8	-0.6	-0.6	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.5	1.6	0.8	1.2	1.3	1.1	0.1	0.8
Whole body fat-free mass	0.1	0.7	2.3	0.4	0.8	-0.1	1.1	1.5	-0.8	0.3
Leg fat-free mass (right)	0.2	1.3	3.5	0.9	1.2	0.1	1.5	1.9	-0.7	0.6
Arm fat percentage (left)	0.1	0.4	0.8	0.7	-0.0	0.8	-0.0	-0.5	0.6	-0.9
Average weekly red wine intake	1.4	2.1	5.1	-0.2	-1.1	2.2	-0.9	-1.0	1.7	-1.8
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.0	-0.2	0.5	0.7	1.1	1.4	0.4	0.7
Mood swings	0.3	0.6	1.1	-1.0	-0.8	-0.5	-0.8	-0.7	0.8	-0.5
Loneliness, isolation	0.1	0.2	0.5	-0.0	-0.1	-0.2	-0.7	-0.7	0.2	-0.2
Long-standing illness, disability or infirmity	2.8	4.3	5.8	-2.0	-2.4	0.7	-2.1	-2.4	2.0	-2.3
Ever had bowel cancer screening	1.3	1.5	3.2	-1.0	-1.3	1.0	-1.0	-1.3	1.8	-1.2
Diabetes diagnosed by doctor	2.6	4.3	7.0	-1.5	-2.3	1.2	-2.4	-2.5	1.4	-2.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.8	-0.1	0.5	0.1	0.3	0.9	-0.6	0.8
Friendships satisfaction	0.9	1.1	2.2	-0.7	-1.1	-0.3	-1.5	-1.3	0.1	-1.4
Qualifications: nursing, teaching	0.5	0.7	3.0	-1.0	-0.8	0.4	-0.1	-0.2	1.7	-0.6
Commuting to job workplace: Walk	0.8	0.9	2.2	-0.1	-1.0	1.1	-0.8	-0.9	0.3	-1.5
Eye problems/disorders: Cataract	2.3	2.7	4.1	-1.9	-2.0	-0.8	-1.9	-1.9	0.5	-1.7
Mouth/teeth dental problems: Mouth ulcers	1.2	2.0	3.7	-1.9	-1.7	-0.6	-1.3	-1.2	0.9	-1.7
Medication for cholesterol	0.3	0.4	1.5	0.4	-0.5	-0.4	-0.4	-1.2	0.3	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.4	-0.3	0.3	-0.1	-0.2	0.5	-0.5
Back pain experienced in last month	1.4	2.1	4.1	-1.4	-1.5	1.5	-0.5	-0.4	1.9	-2.0
Mineral and other dietary supplements	0.1	0.1	0.3	0.1	-0.1	0.3	0.5	0.3	0.5	-0.1
Breast cancer (self-reported)	2.5	3.0	7.9	1.3	2.1	-1.3	0.3	0.8	-2.8	2.1
Asthma (self-reported)	2.0	4.0	7.6	-2.5	-2.0	-1.4	-2.8	-2.3	0.1	-1.8
Osteoporosis (self-reported)	1.0	1.2	3.1	-1.8	-0.4	-1.4	-0.9	0.1	-1.6	-0.5
Osteoarthritis (self-reported)	1.9	2.5	5.5	0.6	1.6	-2.4	1.4	1.3	-0.8	2.2
Medication: Aspirin	1.4	1.8	2.4	-1.6	-1.5	-0.7	-1.4	-1.5	0.9	-1.5
Medication: Gliclazide	1.6	1.8	4.0	-0.4	-1.6	1.4	-1.0	-1.4	1.1	-2.0
Illnesses of father: None of the above (group 1)	0.6	0.8	1.8	0.8	0.8	-0.0	1.1	0.5	1.1	1.3
Smoking status: Current	0.6	1.0	2.4	0.2	0.9	-0.3	1.3	1.5	-0.1	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	4.0	1.2	1.9	0.6	1.6	2.0	-0.7	1.8
Whole body water mass	0.1	0.7	2.3	0.4	0.8	0.0	1.0	1.5	-0.7	0.2
Leg predicted mass (right)	0.2	1.1	3.2	0.8	1.1	0.1	1.5	1.8	-0.7	0.6
Arm fat mass (left)	0.1	0.3	1.3	0.3	-0.1	0.7	-0.1	-0.1	0.2	-1.1
Number of self-reported non-cancer illnesses	1.2	2.0	5.4	-2.3	-1.4	-0.9	-1.4	-1.3	1.1	-0.9
Average weekly champagne plus white wine intake	0.9	1.2	3.8	0.8	1.1	-1.4	0.0	0.0	-1.9	1.1
Miserableness	0.2	0.3	0.6	-0.3	-0.7	-0.6	-0.5	-0.8	0.3	-0.7
Guilty feelings	4.1	6.1	12.6	-2.6	-3.0	-0.5	-1.7	-2.7	3.6	-2.0
Wears glasses or contact lenses	0.1	0.1	0.3	0.4	0.1	0.5	-0.1	-0.3	0.5	0.2
Ever taken oral contraceptive pill	0.2	0.3	0.8	-0.2	0.4	-0.9	-0.0	0.4	-0.8	0.3
Hearing aid user	0.7	0.8	2.2	-0.1	0.8	-1.5	-0.0	0.6	-1.4	0.8
Mother’s age at death	0.3	0.4	1.4	-0.5	-0.4	-1.2	-0.2	-0.6	0.6	0.0
Financial situation satisfaction	0.2	0.3	1.0	0.3	-0.4	0.6	-0.2	-0.4	1.0	-0.5
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.8	-1.3	-0.1	-1.7	-0.7	0.4	-1.3	-0.1
Commuting to job workplace: Public transport	0.4	0.4	1.4	0.8	0.6	-0.5	0.4	0.6	-1.2	0.1
Eye problems/disorders: Glaucoma	0.8	1.0	3.5	0.5	0.7	0.7	1.1	0.7	1.9	0.5
Medication: Blood pressure	0.8	1.6	3.4	0.5	0.8	1.7	1.6	1.8	0.7	0.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.8	0.9	0.8	0.3	0.8	0.2	0.3	0.6
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.7	-0.5	-0.5	-0.4	-0.8	-0.6	-0.4	-0.3
High cholesterol (Self-reported)	0.5	0.9	2.9	-0.9	0.4	-1.7	-0.6	-0.1	-1.3	0.8
Medication: Bendroflumethiazide	1.2	1.8	5.4	0.7	0.1	2.1	1.3	0.7	2.3	-0.1
Medication: Paracetamol	0.4	0.7	1.2	-1.1	-0.9	0.6	-0.7	-0.3	0.9	-0.9
Medication: Lisinopril	1.5	2.0	4.2	1.2	0.4	2.0	1.7	0.9	2.1	0.5
Medication: Atorvastatin	0.7	0.8	2.4	0.4	1.2	0.2	0.9	1.5	-0.7	0.6
Illnesses of father: High blood pressure	1.4	1.8	4.5	-1.1	-1.7	0.8	-1.4	-1.1	-0.1	-2.1
Alcohol drinker status: Never	0.3	0.4	1.5	-1.2	-0.6	0.2	-0.2	0.1	0.4	-0.7
Ever smoked	0.4	0.7	1.5	-0.9	-0.9	-0.9	-1.0	-1.2	0.3	-0.3
Basal metabolic rate	0.1	0.4	1.5	0.2	0.6	0.0	0.7	1.2	-0.6	-0.1
Leg fat percentage (left)	0.6	2.2	5.1	-1.1	-1.4	0.5	-1.7	-1.7	1.0	-2.2
Arm fat-free mass (left)	0.1	0.3	0.9	-0.4	0.2	-0.1	0.2	1.0	-0.7	-0.7
Number of operations (self-reported)	0.7	1.1	2.9	0.4	-0.6	1.7	-0.2	-1.0	1.5	-1.0
Average weekly beer plus cider intake	0.9	1.3	3.4	-1.8	-0.7	-1.2	-1.6	-0.3	-0.8	-0.7
Irritability	2.1	3.6	9.8	-1.5	-2.4	1.0	-0.5	-1.4	3.1	-2.0
Risk taking	1.5	2.2	4.2	-1.7	-1.7	1.0	-0.8	-0.6	2.0	-1.8
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.9	0.3	-0.4	0.9	-0.2	-0.7	0.8	-0.7
Fractured/broken bones in last 5 years	1.1	1.5	2.9	0.8	1.2	0.3	1.7	1.7	-0.4	1.4
Age started oral contraceptive pill	1.1	1.4	2.2	-1.0	-1.3	-1.4	-1.2	-1.5	0.1	-1.2
Diastolic blood pressure, automated reading	1.7	5.2	7.8	2.1	2.7	0.6	2.8	2.7	-1.1	2.8
Ever depressed for a whole week	0.6	0.7	1.6	-1.3	-0.7	-1.2	-1.0	-0.7	-0.2	-0.3
Unable to work because of sickness or disability	0.7	0.9	2.5	0.3	1.1	-1.4	0.4	0.5	-0.3	1.6
Commuting to job workplace: Cycle	0.7	0.8	1.6	1.3	1.1	0.7	0.9	0.8	-0.6	0.8
Myopia	1.0	1.4	2.0	-0.9	-1.3	1.0	-1.0	-1.2	1.4	-1.4
Vascular/heart problems diagnosed by doctor	0.3	0.9	3.3	1.0	0.2	-0.5	-0.9	-0.7	-1.8	-0.4
Cholesterol lowering medication	0.3	0.4	1.2	-0.6	0.4	-0.8	-0.1	0.7	-1.1	0.1
Medication: Omeprazole (e.g. Zanprol)	3.6	4.4	11.0	-3.3	-2.5	-0.2	-2.2	-1.5	1.2	-2.2
Pain experienced in last month	0.1	0.1	0.3	0.5	0.0	0.5	-0.5	-0.6	-0.1	-0.1
Supplements: Calcium	2.8	3.1	5.2	-1.7	-2.1	0.5	-2.0	-2.3	1.6	-1.7
Basal cell carcinoma (self-reported)	0.2	0.3	0.6	-0.4	-0.5	-0.6	-0.8	-0.5	0.1	-0.5
Heart attack/myocardial infarction (self-reported)	0.8	1.1	2.4	-0.6	1.0	-1.5	0.2	1.0	-1.2	1.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	-0.1	-0.5	0.7	-0.5	-0.6	0.6	-0.7
Heart disease (siblings)	0.3	0.4	0.9	-0.8	-0.4	0.2	-0.9	-0.3	-0.5	-0.8
Alcohol drinker status: Previous	0.4	0.5	1.1	-0.2	-0.9	0.6	-0.5	-0.6	0.9	-1.1
Pack years of smoking	0.5	0.7	1.6	-0.8	-0.8	-0.6	-0.6	-1.0	1.3	0.1
Impedance of whole body	1.4	7.3	13.9	-2.3	-3.3	0.2	-3.0	-3.7	2.3	-2.5
Leg fat mass (left)	0.4	1.7	4.9	-1.0	-1.4	0.4	-1.4	-1.2	0.6	-2.2
Arm predicted mass (left)	0.1	0.3	0.9	-0.4	0.2	-0.4	0.2	1.0	-0.7	-0.4