TWAS hub - C11orf17

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.0440	0.0380	4.2e-03	0.010	0.026	0.052	NA	0.025	4.4e-02	2.6e-03	3.3e-05	NA	2.9e-03
2	TCGA	Breast Invasive Carcinoma	0.0127	0.0100	5.3e-03	0.009	0.012	0.004	NA	0.010	4.0e-03	1.5e-03	3.8e-02	NA	3.4e-03
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.3522	0.1440	2.3e-07	0.051	0.067	0.068	NA	0.063	2.0e-06	5.6e-08	3.9e-08	NA	1.3e-07
4	TCGA	Brain Lower Grade Glioma	0.0979	0.0443	5.6e-07	0.029	0.053	0.050	NA	0.054	2.7e-04	1.1e-06	2.4e-06	NA	9.2e-07
5	TCGA	Lung Adenocarcinoma	0.0857	0.0537	9.1e-03	0.021	0.009	0.010	NA	0.012	1.5e-03	3.0e-02	2.3e-02	NA	1.3e-02
6	TCGA	Lung Squamous Cell Carcinoma	0.0252	0.0188	9.0e-03	0.025	0.012	0.001	NA	0.018	7.1e-04	1.3e-02	2.4e-01	NA	3.4e-03
7	TCGA	Testicular Germ Cell Tumors	0.1050	0.0780	2.3e-03	0.057	0.085	0.073	NA	0.050	4.7e-03	6.5e-04	1.5e-03	NA	7.4e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Stomach or abdominal pain in last month	7.3	9.1	14.8	-3.9	-3.6	0.1	-2.7	-3.0	3.1	-3.1
Blood Platelet Count	6.4	74.1	193.2	4.0	8.9	-10.5	1.8	5.2	-13.9	9.4
Shortness of breath walking on level ground	5.0	5.9	9.3	-2.6	-3.1	-0.3	-2.4	-2.8	2.2	-2.6
Heel T-Score	4.7	37.6	59.3	7.6	3.6	7.7	7.7	3.1	7.4	3.1
Medication: Ventolin 100micrograms inhaler	4.7	6.0	10.2	-3.2	-2.8	-0.8	-2.9	-2.4	1.2	-2.8
Emphysema/chronic bronchitis	4.4	4.9	7.8	-2.6	-2.2	-2.8	-2.5	-2.5	0.6	-1.4
Lung FEV1/FVC ratio	4.3	21.6	41.7	4.5	4.4	4.2	6.4	6.5	0.5	3.3
Guilty feelings	4.1	6.1	12.6	-2.6	-3.0	-0.5	-1.7	-2.7	3.6	-2.0
Medication: Ramipril	3.8	4.8	7.9	1.8	2.5	-0.3	2.5	2.8	-1.6	2.8
Health satisfaction	3.7	4.8	7.3	-2.5	-2.7	0.7	-2.0	-2.1	2.2	-2.6
Illnesses of mother	3.6	4.4	7.3	1.9	2.5	-1.3	1.5	1.9	-2.7	2.5
Medication: Omeprazole (e.g. Zanprol)	3.6	4.4	11.0	-3.3	-2.5	-0.2	-2.2	-1.5	1.2	-2.2
Allergy	3.5	8.0	14.4	2.3	3.2	-0.3	3.2	3.8	-2.4	3.2
Respiratory disease	3.4	7.5	12.9	-3.3	-2.8	-1.3	-3.6	-3.5	0.8	-2.5
Hair/balding pattern: Pattern 2	3.4	4.3	6.5	-1.6	-2.4	1.5	-2.4	-2.4	1.3	-2.5
Hair/balding pattern: Pattern 3	3.3	5.0	7.1	1.5	2.6	-1.8	1.9	2.4	-2.5	2.7
Blood Red Count	3.0	29.0	114.5	2.3	5.3	-5.7	-0.8	2.3	-10.7	4.0
Allergy or Eczema	3.0	7.9	13.0	-1.1	-3.0	2.1	-2.2	-3.6	3.5	-3.2
Worry (Nagel 2018)	2.9	6.0	16.8	-1.4	-2.7	1.1	-1.3	-2.9	4.1	-2.1
Worry too long after embarrassment	2.9	4.9	14.6	0.1	-2.2	1.3	-0.8	-3.1	3.8	-1.7
Eye problems/disorders: None of the above	2.9	3.3	5.7	0.8	2.0	-0.7	1.4	2.3	-2.4	2.2
Neuroticism (2016)	2.8	4.1	6.6	-2.4	-2.6	-1.1	-1.9	-2.1	2.0	-1.7
Taking other prescription medications	2.8	4.3	7.4	-2.7	-2.3	-1.2	-2.7	-2.3	0.3	-1.9
Had major operations	2.8	3.3	8.0	-0.7	-1.9	0.3	-2.0	-2.8	1.6	-2.1
Long-standing illness, disability or infirmity	2.8	4.3	5.8	-2.0	-2.4	0.7	-2.1	-2.4	2.0	-2.3
Supplements: Calcium	2.8	3.1	5.2	-1.7	-2.1	0.5	-2.0	-2.3	1.6	-1.7
Mean Putamen Volume	2.7	3.0	5.4	1.4	1.7	-2.2	1.5	1.2	-1.6	2.3
Qualifications: CSEs or equivalent	2.7	3.6	5.5	1.8	2.3	-0.4	2.0	2.2	-1.6	2.3
Overall health rating	2.7	5.7	14.7	-3.8	-2.6	-1.5	-2.4	-2.0	1.6	-2.0
Illnesses of father: Heart disease	2.7	3.7	7.5	-1.6	-2.3	0.4	-2.3	-2.3	0.3	-2.7
Hayfever, allergic rhinitis or eczema	2.6	5.6	8.3	-1.1	-2.7	1.7	-1.8	-2.8	2.9	-2.9
Impedance of leg (left)	2.6	12.6	20.6	-3.6	-4.3	-0.2	-4.4	-4.5	2.0	-3.7
Wheeze or whistling in the chest in last year	2.6	4.6	8.8	-2.4	-2.6	1.3	-2.0	-1.6	1.5	-3.0
Diabetes diagnosed by doctor	2.6	4.3	7.0	-1.5	-2.3	1.2	-2.4	-2.5	1.4	-2.6
Waist Hip Ratio (WHR)	2.5	11.3	20.2	-2.9	-3.7	1.1	-2.9	-3.4	4.5	-4.0
Other serious medical condition/disability diagnosed by doctor	2.5	3.3	7.0	-2.2	-2.1	0.6	-1.1	-1.4	2.6	-1.8
Impedance of leg (right)	2.5	12.2	19.3	-3.5	-4.3	0.4	-4.1	-4.4	2.4	-3.7
Neuroticism score	2.5	5.2	13.1	-1.5	-2.6	0.1	-1.5	-2.9	3.6	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	2.5	3.3	9.1	-2.3	-2.0	-0.2	-0.8	-1.2	3.0	-1.6
Chest pain or discomfort	2.5	3.6	6.7	-2.6	-2.4	-0.5	-1.7	-1.7	1.6	-2.2
Breast cancer (self-reported)	2.5	3.0	7.9	1.3	2.1	-1.3	0.3	0.8	-2.8	2.1
Worrier / anxious feelings	2.3	4.4	9.4	-1.5	-2.5	0.3	-1.5	-2.7	3.1	-1.7
Eye problems/disorders: Cataract	2.3	2.7	4.1	-1.9	-2.0	-0.8	-1.9	-1.9	0.5	-1.7
Ulcerative Colitis (UC)	2.2	4.1	7.7	-2.8	-2.7	0.5	-1.4	-1.3	2.0	-2.3
Reaction Time	2.2	4.2	7.9	-0.3	-2.2	1.8	-1.9	-2.8	1.6	-2.7
Type 2 Diabetes (T2D) (2018)	2.2	4.1	6.2	-1.6	-2.4	1.0	-2.4	-2.4	1.3	-2.5
Number of incorrect matches in round	2.2	3.7	10.6	-0.1	-1.6	3.2	0.0	-0.5	2.6	-2.4
Tense / ‘highly strung’	2.2	3.6	10.4	-1.5	-2.2	0.9	-1.1	-1.8	3.2	-1.6
Neuroticism (Nagel 2018)	2.1	5.0	13.3	-1.0	-2.5	1.9	-0.9	-2.3	3.7	-2.2
Medication: Atenolol	2.1	2.6	5.3	0.8	1.8	-2.0	0.9	1.2	-1.8	2.3
Nervous feelings	2.1	3.9	12.4	-1.7	-2.2	0.2	-1.0	-2.0	3.5	-1.5
Fluid intelligence score	2.1	4.4	6.3	-2.5	-2.4	-0.4	-2.4	-2.5	1.5	-2.1
Medication: Omeprazole	2.1	2.5	6.8	-2.6	-1.7	-0.6	-1.8	-1.1	0.5	-1.6
Illnesses of siblings: Diabetes	2.1	2.6	4.8	-1.4	-1.8	0.1	-1.7	-2.2	1.8	-1.5
Irritability	2.1	3.6	9.8	-1.5	-2.4	1.0	-0.5	-1.4	3.1	-2.0
Lupus	2.0	3.0	6.2	-0.7	-1.9	1.8	-0.7	-1.3	2.3	-2.5
Heart disease (mother)	2.0	2.5	4.5	-1.1	-1.7	1.3	-0.9	-1.4	2.1	-2.1
Asthma (self-reported)	2.0	4.0	7.6	-2.5	-2.0	-1.4	-2.8	-2.3	0.1	-1.8
Neuroticism	1.9	4.5	11.4	-1.1	-2.5	0.4	-1.3	-2.7	3.4	-1.9
Townsend deprivation index at recruitment	1.9	2.6	6.0	-0.2	1.6	-1.3	1.3	2.4	-1.6	2.0
Diverticular disease/diverticulitis (self-reported)	1.9	2.3	4.5	-1.6	-1.8	-0.8	-0.9	-1.5	2.1	-1.4
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	6.1	-0.5	-1.9	1.2	-1.2	-1.7	1.4	-2.5
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	4.5	-2.1	-1.9	-0.8	-1.9	-2.1	1.6	-1.5
Medication: Lansoprazole	1.9	2.2	3.5	-1.8	-1.8	-0.1	-1.4	-1.6	1.9	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	4.3	-1.9	-1.9	-1.3	-1.5	-2.1	1.9	-1.0
Osteoarthritis (self-reported)	1.9	2.5	5.5	0.6	1.6	-2.4	1.4	1.3	-0.8	2.2
Verbal and Numeric Reasoning (VNR)	1.8	4.4	7.3	-2.7	-2.3	-1.1	-2.1	-2.3	2.0	-1.8
Diabetes (mother)	1.8	2.2	7.3	-0.9	-1.2	1.8	-0.2	-0.4	2.7	-1.6
Asthma	1.8	3.6	7.0	-2.4	-1.7	-1.4	-2.6	-2.2	-0.0	-1.6
HbA1C	1.7	1.8	5.4	-0.8	1.0	-2.3	-0.1	1.0	-2.0	0.9
Ulcerative Colitis	1.7	2.4	6.4	-1.3	-2.0	1.3	-0.3	-0.8	2.5	-1.7
Falls in the last year	1.7	2.3	4.7	-2.2	-1.8	-0.1	-1.3	-1.1	1.4	-1.7
Diastolic blood pressure, automated reading	1.7	5.2	7.8	2.1	2.7	0.6	2.8	2.7	-1.1	2.8
Alzheimer’s Disease (in mother)	1.6	1.9	4.1	-1.0	-1.6	-0.2	-1.7	-2.0	0.9	-1.4
Irritable Bowel Disease (IBD)	1.6	3.9	7.7	-2.8	-2.4	0.8	-1.0	-1.2	2.7	-1.9
Multivitamins +/- minerals	1.6	2.0	3.9	-0.4	-1.6	0.5	-1.7	-2.0	0.6	-1.9
Peak expiratory flow (PEF)	1.6	3.6	9.1	1.4	2.3	0.7	2.4	3.0	-0.7	1.5
Medication: Gliclazide	1.6	1.8	4.0	-0.4	-1.6	1.4	-1.0	-1.4	1.1	-2.0
Hearing difficulty/problems: Yes	1.5	2.3	6.3	0.1	1.6	-1.2	1.6	2.5	-1.2	1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.3	13.5	0.8	-0.2	2.5	1.7	0.5	3.7	-0.3
Medication: Allopurinol	1.5	2.0	4.4	1.9	1.8	0.4	1.0	0.9	-1.0	2.1
Mean time to correctly identify matches	1.5	2.8	6.2	-0.0	-1.7	1.4	-1.5	-2.5	1.5	-2.0
Suffer from ‘nerves’	1.5	2.4	5.4	-1.3	-1.8	-0.0	-1.1	-1.9	2.3	-1.3
Medication: Lisinopril	1.5	2.0	4.2	1.2	0.4	2.0	1.7	0.9	2.1	0.5
Risk taking	1.5	2.2	4.2	-1.7	-1.7	1.0	-0.8	-0.6	2.0	-1.8
Vitamin and mineral supplements	1.4	1.9	3.8	0.6	1.6	-0.2	1.8	1.9	0.0	1.9
Average weekly red wine intake	1.4	2.1	5.1	-0.2	-1.1	2.2	-0.9	-1.0	1.7	-1.8
Back pain experienced in last month	1.4	2.1	4.1	-1.4	-1.5	1.5	-0.5	-0.4	1.9	-2.0
Medication: Aspirin	1.4	1.8	2.4	-1.6	-1.5	-0.7	-1.4	-1.5	0.9	-1.5
Illnesses of father: High blood pressure	1.4	1.8	4.5	-1.1	-1.7	0.8	-1.4	-1.1	-0.1	-2.1
Impedance of whole body	1.4	7.3	13.9	-2.3	-3.3	0.2	-3.0	-3.7	2.3	-2.5
Number of treatments/medications taken	1.3	2.3	4.9	-2.2	-1.7	-0.9	-2.0	-1.5	0.4	-1.2
Medication: Levothyroxine sodium	1.3	2.3	7.7	-0.6	0.9	-2.8	-0.4	0.2	-2.0	1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	11.4	1.2	-0.2	2.4	1.5	-0.1	3.4	-0.1
Father’s age at death	1.3	1.7	3.8	-0.3	-1.5	0.2	-1.4	-1.9	1.0	-1.8
Angina (self-reported)	1.3	1.7	4.2	-1.4	-0.7	-2.0	-1.7	-1.6	-0.1	-0.1
Ever had bowel cancer screening	1.3	1.5	3.2	-1.0	-1.3	1.0	-1.0	-1.3	1.8	-1.2
Fasting Glucose	1.2	1.5	3.1	1.1	1.3	-1.5	0.5	0.8	-1.8	1.1
Angina	1.2	1.6	3.2	-1.5	-0.8	-1.8	-1.7	-1.6	0.1	-0.3
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	5.7	-0.6	-1.4	0.4	-0.8	-1.9	2.4	-0.9
Alcohol intake versus 10 years previously	1.2	1.8	4.2	0.1	1.6	-0.9	0.7	1.5	-2.0	1.5
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	3.5	0.9	1.4	-0.3	1.6	1.9	-0.4	1.2
Pulse wave reflection index	1.2	1.5	5.7	-1.1	0.4	-2.4	-0.8	-0.1	-1.4	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	5.3	0.7	1.2	-0.4	0.3	1.1	-2.3	1.0
Pulse rate, automated reading	1.2	3.8	6.7	-1.4	-2.3	0.4	-1.8	-2.6	2.0	-2.2
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	2.9	-0.5	-1.4	0.9	-1.4	-1.7	0.2	-1.5
Mouth/teeth dental problems: Mouth ulcers	1.2	2.0	3.7	-1.9	-1.7	-0.6	-1.3	-1.2	0.9	-1.7
Number of self-reported non-cancer illnesses	1.2	2.0	5.4	-2.3	-1.4	-0.9	-1.4	-1.3	1.1	-0.9
Medication: Bendroflumethiazide	1.2	1.8	5.4	0.7	0.1	2.1	1.3	0.7	2.3	-0.1
Major Depression (MDD)	1.1	1.3	2.2	-0.9	-1.2	-1.1	-1.5	-1.4	0.9	-0.9
Systolic blood pressure, automated reading	1.1	3.3	5.5	1.7	2.0	1.7	2.4	1.9	0.5	2.1
Migraine (self-reported)	1.1	1.4	4.2	-1.9	-0.9	-2.1	-0.9	-0.6	0.1	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	4.4	-1.5	-0.7	-2.1	-1.1	-0.8	-0.6	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	4.0	1.2	1.9	0.6	1.6	2.0	-0.7	1.8
Fractured/broken bones in last 5 years	1.1	1.5	2.9	0.8	1.2	0.3	1.7	1.7	-0.4	1.4
Age started oral contraceptive pill	1.1	1.4	2.2	-1.0	-1.3	-1.4	-1.2	-1.5	0.1	-1.2
Bipolar Disorder (2011)	1.0	0.9	2.7	-0.3	-0.6	1.3	-0.2	-0.5	1.6	-1.1
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.2	0.2	-1.0	1.2	-0.4	-0.8	1.5	-1.4
Heart attack	1.0	1.3	3.0	-0.5	1.1	-1.7	0.2	1.0	-1.4	1.1
Diabetes (self-reported)	1.0	1.5	3.0	-0.7	-1.3	0.6	-1.5	-1.7	0.8	-1.4
Impedance of arm (right)	1.0	4.7	9.1	-1.1	-2.7	1.0	-2.0	-3.0	2.3	-2.2
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.4	-1.0	-1.3	0.7	-1.0	-0.7	0.9	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	6.9	1.0	1.6	1.4	2.5	2.6	0.6	1.6
Glaucoma (self-reported)	1.0	1.2	6.3	-0.6	-0.5	1.0	0.4	0.2	2.5	-0.7
Gout (self-reported)	1.0	1.4	3.5	1.2	1.5	-0.4	0.5	0.6	-1.3	1.9
Medication: Amlodipine	1.0	1.5	6.2	-0.4	-0.9	1.6	0.3	-0.4	2.5	-0.4
Family relationship satisfaction	1.0	1.2	3.3	1.3	0.7	1.8	1.1	1.4	0.1	-0.1
Osteoporosis (self-reported)	1.0	1.2	3.1	-1.8	-0.4	-1.4	-0.9	0.1	-1.6	-0.5
Myopia	1.0	1.4	2.0	-0.9	-1.3	1.0	-1.0	-1.2	1.4	-1.4
Blood White Count	0.9	6.8	26.3	-0.3	1.7	-3.6	-1.9	-0.1	-5.1	1.3
Hand grip strength (left)	0.9	2.4	3.9	2.0	1.5	1.0	1.8	1.9	-1.2	1.1
Ever had hysterectomy (womb removed)	0.9	1.0	2.8	0.4	1.1	-1.2	0.2	0.8	-1.7	0.9
Diabetes (father)	0.9	1.1	2.9	-1.1	-1.4	0.5	-0.9	-0.6	0.5	-1.7
Fed-up feelings	0.9	1.6	2.5	0.4	1.2	-1.6	1.2	1.6	-1.0	1.4
High blood pressure (mother)	0.9	1.2	2.6	-1.5	-1.2	0.4	-0.8	-0.8	1.6	-0.9
Alcohol usually taken with meals	0.9	1.5	3.4	-0.8	-1.3	0.3	-1.5	-1.4	0.0	-1.8
Time employed in main current job	0.9	1.0	3.3	-0.1	-1.1	0.0	-0.3	-1.4	1.8	-0.8
Pulse wave Arterial Stiffness index	0.9	1.1	3.8	-0.8	-0.4	-1.9	-0.9	-1.3	0.1	0.5
Hair/balding pattern: Pattern 4	0.9	2.3	5.0	-1.1	-1.7	1.0	-0.8	-1.0	2.1	-2.2
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	4.8	-0.3	-0.4	2.2	0.4	0.2	1.6	-0.8
Number of full brothers	0.9	1.2	2.4	0.9	1.5	-0.4	1.2	1.2	-0.6	1.4
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.6	0.5	0.5	1.2	1.2	0.5	1.6	0.7
Medication: Aspirin	0.9	1.2	1.8	-1.3	-1.3	-0.4	-1.0	-1.1	1.1	-1.4
Friendships satisfaction	0.9	1.1	2.2	-0.7	-1.1	-0.3	-1.5	-1.3	0.1	-1.4
Average weekly champagne plus white wine intake	0.9	1.2	3.8	0.8	1.1	-1.4	0.0	0.0	-1.9	1.1
Average weekly beer plus cider intake	0.9	1.3	3.4	-1.8	-0.7	-1.2	-1.6	-0.3	-0.8	-0.7
Intelligence (Savage-Jansen 2018)	0.8	2.6	3.8	-2.0	-1.9	-0.3	-1.6	-1.9	1.3	-1.7
Prostate Cancer	0.8	1.2	2.5	-0.3	1.0	-1.4	0.2	1.0	-1.6	1.3
Crohns Disease (2012)	0.8	1.3	4.8	-1.8	-0.7	0.1	-0.2	-0.7	2.2	-0.0
Systolic Blood Pressure	0.8	4.0	10.1	0.9	1.2	3.2	2.4	2.0	2.1	1.4
Relative age of first facial hair	0.8	1.7	3.5	1.4	1.2	0.7	1.9	1.5	0.2	1.5
Age when periods started (menarche)	0.8	1.8	6.4	0.4	0.8	-1.0	0.8	1.8	-2.5	0.8
Financial difficulties in last 2 years	0.8	1.1	3.5	1.9	0.7	1.1	1.2	0.8	-0.3	0.2
Illnesses of siblings	0.8	1.1	4.5	0.8	0.8	-1.0	0.0	0.3	-2.1	0.9
Exposure to tobacco smoke at home	0.8	0.9	3.1	-0.6	-0.9	1.1	-0.9	-0.1	-0.1	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	4.2	2.1	0.8	0.6	0.8	0.3	0.0	0.5
Age at first live birth	0.8	1.4	4.5	0.2	-1.3	0.4	-1.2	-2.1	0.7	-1.2
Commuting to job workplace: Walk	0.8	0.9	2.2	-0.1	-1.0	1.1	-0.8	-0.9	0.3	-1.5
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.8	-1.3	-0.1	-1.7	-0.7	0.4	-1.3	-0.1
Eye problems/disorders: Glaucoma	0.8	1.0	3.5	0.5	0.7	0.7	1.1	0.7	1.9	0.5
Medication: Blood pressure	0.8	1.6	3.4	0.5	0.8	1.7	1.6	1.8	0.7	0.8
Heart attack/myocardial infarction (self-reported)	0.8	1.1	2.4	-0.6	1.0	-1.5	0.2	1.0	-1.2	1.0
Ovarian Cancer	0.7	0.9	3.4	-0.3	0.6	-1.2	-0.0	0.7	-1.8	0.7
Sensitivity / hurt feelings	0.7	1.2	4.8	0.6	-0.8	1.2	0.5	-0.9	2.2	-0.6
Hand grip strength (right)	0.7	2.0	3.5	1.3	1.5	0.2	1.4	1.8	-1.9	1.2
Hearing difficulty/problems with background noise	0.7	1.2	3.4	0.1	1.2	-0.3	1.2	1.8	-0.6	1.1
Pulse wave peak to peak time	0.7	0.9	3.3	0.6	0.2	1.8	0.8	1.1	-0.0	-0.6
Qualifications: College or University degree	0.7	2.1	4.1	-0.5	-1.7	1.1	-0.8	-1.4	2.0	-2.0
Number of full sisters	0.7	0.9	2.5	-1.4	0.3	-1.6	0.1	1.1	-0.4	0.2
Hearing aid user	0.7	0.8	2.2	-0.1	0.8	-1.5	-0.0	0.6	-1.4	0.8
Medication: Atorvastatin	0.7	0.8	2.4	0.4	1.2	0.2	0.9	1.5	-0.7	0.6
Number of operations (self-reported)	0.7	1.1	2.9	0.4	-0.6	1.7	-0.2	-1.0	1.5	-1.0
Unable to work because of sickness or disability	0.7	0.9	2.5	0.3	1.1	-1.4	0.4	0.5	-0.3	1.6
Commuting to job workplace: Cycle	0.7	0.8	1.6	1.3	1.1	0.7	0.9	0.8	-0.6	0.8
Alzheimer’s Disease (including proxy)	0.6	0.8	3.7	-0.3	-0.4	-1.9	-0.5	-1.0	0.6	-0.2
Crohns Disease (2017)	0.6	1.3	3.7	-1.8	-1.0	0.5	-0.3	-0.6	1.9	-0.6
Supplements: Zinc	0.6	0.7	1.7	-0.5	-0.5	-0.4	-1.3	-0.3	-0.9	-1.2
Current tobacco smoking	0.6	1.0	2.4	0.1	0.9	-1.0	1.0	1.3	-0.5	1.5
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.2	-1.1	-0.6	-1.5	-0.7	-0.7	0.5	-0.1
Mouth/teeth dental problems	0.6	0.8	1.8	1.3	0.8	0.2	1.2	0.6	0.4	1.2
Depression (self-reported)	0.6	0.8	3.2	-0.7	-0.9	-0.1	-0.2	-0.7	1.8	-0.6
Impedance of arm (left)	0.6	2.6	6.1	-0.8	-1.9	0.5	-1.5	-2.5	1.9	-1.2
Loud music exposure frequency	0.6	0.7	1.8	1.3	0.8	-0.3	0.9	0.4	0.1	1.1
Body fat percentage	0.6	2.2	5.2	-0.9	-1.5	0.7	-1.5	-1.8	1.1	-2.3
Leg fat percentage (right)	0.6	2.2	4.8	-1.1	-1.4	0.7	-1.6	-1.7	1.1	-2.2
Medication: Blood pressure	0.6	1.0	2.2	1.1	0.9	-0.1	1.5	0.6	0.8	1.5
Illnesses of father: None of the above (group 1)	0.6	0.8	1.8	0.8	0.8	-0.0	1.1	0.5	1.1	1.3
Smoking status: Current	0.6	1.0	2.4	0.2	0.9	-0.3	1.3	1.5	-0.1	1.5
Leg fat percentage (left)	0.6	2.2	5.1	-1.1	-1.4	0.5	-1.7	-1.7	1.0	-2.2
Ever depressed for a whole week	0.6	0.7	1.6	-1.3	-0.7	-1.2	-1.0	-0.7	-0.2	-0.3
Coronary Artery Disease (CAD)	0.5	0.6	1.7	0.3	0.7	0.1	1.2	1.3	0.1	0.4
LDL Cholesterol	0.5	0.8	3.3	-0.1	0.6	-1.1	-0.2	0.8	-1.8	0.5
Schizophrenia (2014)	0.5	1.0	2.5	-1.6	-1.0	0.3	-0.2	0.2	1.3	-1.4
Tanning	0.5	5.5	13.0	2.1	2.7	-1.4	1.1	1.7	-3.6	2.8
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.4	-0.1	-0.3	0.9	-1.0	-1.2	0.0	-0.6
Medication: Co-codamol	0.5	0.6	2.2	-1.0	-0.2	-1.5	-0.7	-0.1	-0.8	0.2
Trunk fat percentage	0.5	2.0	4.5	-0.9	-1.5	0.5	-1.5	-1.7	1.1	-2.1
High blood pressure	0.5	1.4	4.3	-0.4	0.1	1.3	1.5	1.1	2.1	0.7
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	5.0	0.6	1.2	0.8	1.8	2.2	-0.0	1.0
Birth weight of first child	0.5	0.9	2.6	0.0	-0.1	1.6	0.7	0.5	1.6	-0.4
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.1	-0.7	0.0	-1.4	-0.7	-0.2	-0.8	0.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	3.3	-1.0	0.0	-1.8	-0.8	-0.3	-1.2	0.6
Alcohol intake frequency.	0.5	1.2	4.7	-2.2	-1.1	-0.6	-0.9	-0.0	0.2	-1.0
Leg pain on walking	0.5	0.6	1.0	-1.0	-0.7	-0.7	-0.9	-0.8	0.9	-0.3
Hypertension (Self-reported)	0.5	1.3	4.0	-0.4	0.2	1.1	1.4	1.1	2.0	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.5	1.6	0.8	1.2	1.3	1.1	0.1	0.8
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.0	-0.2	0.5	0.7	1.1	1.4	0.4	0.7
Qualifications: nursing, teaching	0.5	0.7	3.0	-1.0	-0.8	0.4	-0.1	-0.2	1.7	-0.6
High cholesterol (Self-reported)	0.5	0.9	2.9	-0.9	0.4	-1.7	-0.6	-0.1	-1.3	0.8
Pack years of smoking	0.5	0.7	1.6	-0.8	-0.8	-0.6	-0.6	-1.0	1.3	0.1
Bipolar Disorder (2018)	0.4	0.6	1.5	-1.2	-0.6	-0.7	-0.9	-0.0	-0.5	-0.9
Bipolar Disorder or Schizophrenia	0.4	1.0	2.8	-1.7	-1.1	-0.1	-0.6	0.1	0.7	-1.5
Schizophrenia (2018)	0.4	0.8	1.8	-1.2	-0.9	0.4	0.0	0.2	1.3	-1.2
Age at First Birth	0.4	0.5	1.2	1.1	0.7	0.6	0.9	0.7	0.2	0.6
Primary Biliary Cirrhosis	0.4	0.5	0.9	0.7	0.8	-0.8	0.9	0.9	0.1	0.6
Height	0.4	8.6	15.8	-3.2	-4.0	-0.0	-2.0	-2.3	3.3	-3.8
Lung FVC	0.4	2.3	4.3	1.2	1.8	-0.7	1.3	1.4	-1.6	2.1
Medication for hormone replacement therapy	0.4	0.5	1.2	-1.1	-0.6	-0.5	-1.1	-0.5	0.0	-0.4
Average weekly fortified wine intake	0.4	0.5	1.3	1.1	0.7	0.3	0.2	0.0	-0.9	0.7
Trunk fat mass	0.4	1.6	4.3	-0.8	-1.3	0.5	-1.2	-1.3	0.9	-2.1
Number of live births	0.4	0.6	1.6	-1.3	-0.4	-0.6	-1.1	-0.2	-0.5	-0.6
Pulse rate	0.4	0.6	1.3	0.0	-1.1	0.6	-0.2	-0.8	0.8	-1.1
Happiness	0.4	0.5	1.2	-0.3	-0.6	0.5	-0.6	-0.7	1.1	-1.0
Mouth/teeth dental problems: Dentures	0.4	0.7	1.7	-0.4	-0.1	-1.3	-1.1	-0.5	-1.2	-0.1
High blood pressure (siblings)	0.4	0.6	3.3	-0.6	0.0	-0.2	0.6	0.6	1.8	0.2
Exposure to tobacco smoke outside home	0.4	0.5	2.2	0.1	-0.5	1.5	-0.1	-0.3	0.8	-0.8
Medication: Ibuprofen	0.4	0.4	0.9	0.7	0.6	0.2	1.0	0.9	0.2	0.5
Leg fat mass (right)	0.4	1.7	4.7	-1.1	-1.3	0.4	-1.4	-1.2	0.7	-2.2
Age at last live birth	0.4	0.6	2.0	0.6	-0.6	0.5	-0.6	-1.4	0.4	-0.7
Commuting to job workplace: Public transport	0.4	0.4	1.4	0.8	0.6	-0.5	0.4	0.6	-1.2	0.1
Medication: Paracetamol	0.4	0.7	1.2	-1.1	-0.9	0.6	-0.7	-0.3	0.9	-0.9
Ever smoked	0.4	0.7	1.5	-0.9	-0.9	-0.9	-1.0	-1.2	0.3	-0.3
Alcohol drinker status: Previous	0.4	0.5	1.1	-0.2	-0.9	0.6	-0.5	-0.6	0.9	-1.1
Leg fat mass (left)	0.4	1.7	4.9	-1.0	-1.4	0.4	-1.4	-1.2	0.6	-2.2
Breast Cancer	0.3	0.7	2.0	0.9	-0.1	1.0	0.5	-0.9	1.4	-0.2
Rheumatoid Arthritis	0.3	0.4	0.8	-0.7	-0.7	0.6	-0.2	-0.3	0.9	-0.7
Blood Eosinophil Count	0.3	2.0	8.1	1.5	1.6	-0.7	-0.2	0.4	-2.8	0.7
Smoking Status	0.3	0.7	1.8	-0.2	0.8	-0.8	0.6	1.1	-0.4	1.3
Hypothyroidism (self reported)	0.3	0.7	1.9	-0.8	-0.2	-1.4	-1.0	-0.8	-1.0	0.3
Chronotype (morning person)	0.3	0.6	2.1	0.8	0.3	1.4	0.7	0.8	0.2	-0.3
Medication: Metformin	0.3	0.4	0.7	0.4	-0.7	0.8	-0.2	-0.8	0.7	-0.7
Maternal smoking around birth	0.3	0.5	1.0	-0.4	0.6	-0.8	0.4	1.0	-0.6	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.1	-0.1	0.7	-0.9	0.3	0.5	-0.5	1.0
Serious illness, injury or assault to yourself	0.3	0.4	2.0	-0.3	0.2	-1.4	-0.1	-0.1	-0.3	0.5
Waist circumference	0.3	1.3	3.2	-1.2	-1.0	-0.4	-1.4	-1.0	0.2	-1.8
Had other major operations	0.3	0.4	1.7	-0.3	0.4	-0.3	-0.7	0.1	-1.3	-0.0
Qualifications: None of the above	0.3	0.6	1.7	0.0	0.9	-0.5	0.7	1.3	-0.7	0.7
Birth weight	0.3	0.7	1.8	-0.4	-1.0	1.1	-0.2	-0.1	0.9	-1.4
Comparative body size at age 10	0.3	0.8	2.6	1.6	0.8	0.8	0.9	0.5	0.7	0.0
Number of children fathered	0.3	0.4	1.1	0.1	-0.2	-0.2	-1.1	-0.9	-0.6	-0.5
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.6	-0.7	-0.4	0.7	-0.8	-0.4	0.5	-0.8
Medication for pain relief, constipation, heartburn	0.3	0.5	2.2	1.5	0.5	0.8	0.4	-0.4	-0.2	0.4
Whole body fat mass	0.3	1.3	4.2	-0.7	-1.1	0.7	-1.1	-1.1	0.7	-2.1
Comparative height size at age 10	0.3	1.5	3.1	-1.0	-1.1	-1.0	-1.8	-1.4	-0.7	-1.3
Mood swings	0.3	0.6	1.1	-1.0	-0.8	-0.5	-0.8	-0.7	0.8	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.8	-0.1	0.5	0.1	0.3	0.9	-0.6	0.8
Medication for cholesterol	0.3	0.4	1.5	0.4	-0.5	-0.4	-0.4	-1.2	0.3	-0.5
Mother’s age at death	0.3	0.4	1.4	-0.5	-0.4	-1.2	-0.2	-0.6	0.6	0.0
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.8	0.9	0.8	0.3	0.8	0.2	0.3	0.6
Alcohol drinker status: Never	0.3	0.4	1.5	-1.2	-0.6	0.2	-0.2	0.1	0.4	-0.7
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.9	0.3	-0.4	0.9	-0.2	-0.7	0.8	-0.7
Vascular/heart problems diagnosed by doctor	0.3	0.9	3.3	1.0	0.2	-0.5	-0.9	-0.7	-1.8	-0.4
Cholesterol lowering medication	0.3	0.4	1.2	-0.6	0.4	-0.8	-0.1	0.7	-1.1	0.1
Heart disease (siblings)	0.3	0.4	0.9	-0.8	-0.4	0.2	-0.9	-0.3	-0.5	-0.8
Schizophrenia vs Biploar Disorder	0.2	0.3	1.1	-0.7	-0.3	1.0	-0.1	0.4	0.5	-0.4
Alzheimer’s Disease (in father)	0.2	0.2	0.6	-0.6	0.0	-0.6	0.1	-0.0	0.8	-0.1
Body Mass Index (BMI) (2010)	0.2	0.3	0.7	0.5	0.7	-0.2	0.1	0.2	-0.8	0.8
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	-0.2	0.1	0.3	0.7	0.5	0.6	-0.0
Cardiovascular Disease	0.2	0.5	1.2	-0.7	0.4	0.4	0.9	1.1	0.7	0.8
Average weekly spirits intake	0.2	0.2	0.4	-0.3	0.1	0.2	0.6	0.4	0.6	0.5
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.5	-0.6	-0.6	-0.6	-0.5	-0.4	-0.1	-0.7
Severe depression (siblings)	0.2	0.2	1.1	-0.3	0.1	-1.1	-0.2	-0.2	-0.3	0.3
Pack years adult smoking proportion	0.2	0.3	1.2	-0.6	-0.5	-0.4	-0.2	-0.5	1.1	0.3
Leg fat-free mass (left)	0.2	0.8	2.5	0.6	0.9	0.3	1.3	1.6	-0.4	0.3
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	-0.2	-0.4	-0.6	-0.2	-0.4	0.7	0.1
Arm fat percentage (right)	0.2	0.7	1.9	0.6	-0.3	1.1	-0.3	-0.7	0.7	-1.4
Hip circumference	0.2	1.0	4.2	-0.4	0.8	-1.2	-0.1	0.8	-2.0	0.2
Standing height	0.2	2.1	4.2	-1.8	-2.1	-0.2	-1.2	-1.1	1.2	-1.8
Length of working week for main job	0.2	0.3	0.6	0.4	-0.0	0.8	0.2	0.5	-0.3	-0.8
Blood clot in the leg (DVT)	0.2	0.2	0.4	-0.1	-0.3	0.6	-0.4	-0.5	0.6	-0.5
Headache pain in last month	0.2	0.4	1.5	-0.8	-0.5	-1.2	-0.1	0.4	-0.5	-0.2
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.5	-0.7	-0.3	-0.0	-0.6	0.1	-0.7	-0.7
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	0.1	-0.4	0.4	-0.6	-0.6	0.1	-0.5
Forced vital capacity (FVC), Best measure	0.2	0.8	1.9	-0.1	0.5	0.8	1.2	1.4	0.7	0.6
Knee pain experienced in last month	0.2	0.3	0.7	0.2	0.6	0.2	0.8	0.8	-0.5	0.6
Smoking status: Previous	0.2	0.3	0.6	-0.3	-0.0	-0.8	-0.8	-0.6	-0.6	0.1
Leg fat-free mass (right)	0.2	1.3	3.5	0.9	1.2	0.1	1.5	1.9	-0.7	0.6
Leg predicted mass (right)	0.2	1.1	3.2	0.8	1.1	0.1	1.5	1.8	-0.7	0.6
Miserableness	0.2	0.3	0.6	-0.3	-0.7	-0.6	-0.5	-0.8	0.3	-0.7
Ever taken oral contraceptive pill	0.2	0.3	0.8	-0.2	0.4	-0.9	-0.0	0.4	-0.8	0.3
Financial situation satisfaction	0.2	0.3	1.0	0.3	-0.4	0.6	-0.2	-0.4	1.0	-0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.7	-0.5	-0.5	-0.4	-0.8	-0.6	-0.4	-0.3
Basal cell carcinoma (self-reported)	0.2	0.3	0.6	-0.4	-0.5	-0.6	-0.8	-0.5	0.1	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	-0.1	-0.5	0.7	-0.5	-0.6	0.6	-0.7
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	-0.2	-0.4	-0.1	-0.4	-0.5	0.3	-0.6
Depression (Nagel 2018)	0.1	0.1	0.2	0.2	0.5	-0.0	0.2	-0.0	0.3	0.5
HDL Cholesterol	0.1	0.2	0.5	0.3	-0.3	-0.3	-0.7	-0.5	-0.3	-0.7
Triglycerides	0.1	0.2	1.1	-0.1	0.0	1.0	0.2	0.1	0.1	-0.1
Hair Pigment	0.1	1.5	4.9	-2.2	-0.8	-1.6	-1.3	-0.8	0.1	-0.0
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.7	-0.1	0.2	0.6	-0.1	-0.1	0.8	0.4
Relative age voice broke	0.1	0.1	0.6	-0.3	-0.0	-0.0	-0.2	0.3	-0.7	0.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.1	-0.3	0.0	-0.5	-0.2	-0.5	-0.5
Supplements: Glucosamine	0.1	0.2	0.4	-0.2	-0.2	0.1	-0.6	-0.3	-0.3	-0.6
Sitting height	0.1	0.6	1.1	-0.8	-1.0	-0.9	-0.4	-0.8	0.7	-0.7
Body mass index (BMI)	0.1	0.3	0.6	0.5	0.7	0.3	0.5	0.7	-0.5	-0.3
Leg predicted mass (left)	0.1	0.7	2.3	0.6	0.8	0.4	1.3	1.5	-0.3	0.2
Past tobacco smoking	0.1	0.2	0.7	0.3	0.1	0.8	0.6	0.6	0.2	-0.4
Had menopause	0.1	0.2	0.9	-0.2	0.0	-0.4	0.1	-0.1	1.0	0.1
Forced vital capacity (FVC)	0.1	0.3	0.6	-0.5	0.3	-0.5	0.3	0.8	-0.6	0.5
Medication: Simvastatin	0.1	0.1	0.3	-0.2	-0.1	-0.6	-0.4	-0.5	-0.2	-0.0
Trunk fat-free mass	0.1	0.7	2.3	0.3	0.8	-0.1	0.9	1.5	-0.9	0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.1	-0.6	-0.5	-1.0	-0.3	-0.3	0.0	-0.4
Medication: Cholesterol lowering	0.1	0.2	0.8	0.5	-0.0	0.2	0.2	-0.5	0.9	0.1
Prospective memory result	0.1	0.2	0.6	-0.8	0.2	-0.3	-0.1	0.4	-0.1	0.5
Arm fat mass (right)	0.1	0.4	2.1	0.1	-0.3	0.8	-0.3	-0.3	0.3	-1.4
Trunk predicted mass	0.1	0.6	2.2	0.3	0.8	-0.1	0.9	1.5	-0.8	0.2
Breastfed as a baby	0.1	0.1	0.3	-0.6	0.1	0.1	-0.1	0.5	0.4	0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.3	0.1	-0.5	0.4	-0.2	-0.6	-0.1	-0.4
Medication: Paracetamol	0.1	0.1	0.4	-0.6	-0.0	-0.1	-0.2	0.4	0.1	0.2
Arm fat-free mass (right)	0.1	0.4	1.3	-0.2	0.5	-0.4	0.5	1.1	-0.7	-0.1
Medication: Seretide 50 evohaler	0.1	0.2	0.5	0.3	0.3	-0.1	0.7	0.5	-0.1	0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	-0.6	-0.1	-0.1	-0.2	0.2	-0.4	-0.0
Supplements: Vitamin C	0.1	0.2	0.5	-0.3	0.0	-0.6	-0.3	0.3	-0.7	-0.2
Whole body fat-free mass	0.1	0.7	2.3	0.4	0.8	-0.1	1.1	1.5	-0.8	0.3
Arm fat percentage (left)	0.1	0.4	0.8	0.7	-0.0	0.8	-0.0	-0.5	0.6	-0.9
Loneliness, isolation	0.1	0.2	0.5	-0.0	-0.1	-0.2	-0.7	-0.7	0.2	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.4	-0.3	0.3	-0.1	-0.2	0.5	-0.5
Mineral and other dietary supplements	0.1	0.1	0.3	0.1	-0.1	0.3	0.5	0.3	0.5	-0.1
Whole body water mass	0.1	0.7	2.3	0.4	0.8	0.0	1.0	1.5	-0.7	0.2
Arm fat mass (left)	0.1	0.3	1.3	0.3	-0.1	0.7	-0.1	-0.1	0.2	-1.1
Wears glasses or contact lenses	0.1	0.1	0.3	0.4	0.1	0.5	-0.1	-0.3	0.5	0.2
Basal metabolic rate	0.1	0.4	1.5	0.2	0.6	0.0	0.7	1.2	-0.6	-0.1
Arm fat-free mass (left)	0.1	0.3	0.9	-0.4	0.2	-0.1	0.2	1.0	-0.7	-0.7
Pain experienced in last month	0.1	0.1	0.3	0.5	0.0	0.5	-0.5	-0.6	-0.1	-0.1
Arm predicted mass (left)	0.1	0.3	0.9	-0.4	0.2	-0.4	0.2	1.0	-0.7	-0.4
BMI	0.0	0.2	0.6	0.8	0.4	0.4	0.2	0.0	-0.1	-0.6
Pain all over the body in last month	0.0	0.1	0.2	-0.5	-0.0	-0.1	0.1	0.2	0.2	0.0
Weight	0.0	0.2	1.1	-0.3	-0.2	0.1	-0.1	0.2	0.0	-1.1
Noisy workplace	0.0	0.0	0.1	-0.3	-0.2	0.1	0.0	0.4	-0.0	-0.2
Lung cancer (father)	0.0	0.0	0.1	0.1	-0.3	0.0	-0.1	-0.1	-0.3	0.1
Neck or shoulder pain in last month	0.0	0.0	0.2	-0.4	-0.1	0.0	-0.1	0.3	-0.1	-0.1
Arm predicted mass (right)	0.0	0.2	0.6	-0.6	-0.0	-0.4	0.1	0.8	-0.5	-0.6

Hub : Genes

C11orf17

Models

Trait associations