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chr17:26,545,488-29,313,078

Best TWAS P=1.98e-22 · Best GWAS P=3.05e-19 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
43	The Cancer Genome Atlas	Lung Adenocarcinoma	SSH2	0.06	0.03	blup	112	0.05	2.5e-06	-8.2	9.7	2.0e-22	0.95	0.04	0.96	TRUE
2	CommonMind	Brain Pre-frontal Cortex	DHRS13	0.04	0.01	blup	304	0.02	6.0e-04	4.6	-6.2	4.4e-10	-0.05	0.06	0.74	TRUE
14	GTEx	Spleen	GIT1	0.15	0.06	lasso	5	0.06	1.4e-02	-8.4	-9.5	1.6e-21	-0.77	0.08	0.62	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SSH2	0.03	0.02	blup	112	0.03	2.4e-04	8.2	8.9	4.4e-19	0.98	0.04	0.95	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	SSH2	0.01	0.01	blup	111	0.01	1.0e-03	-8.5	8.9	4.8e-19	0.98	0.06	0.92	FALSE
11	GTEx	Nerve Tibial	SSH2	0.05	0.06	lasso	10	0.06	7.8e-05	8.8	8.9	5.5e-19	0.99	0.07	0.93	FALSE
42	The Cancer Genome Atlas	Lung Adenocarcinoma	EFCAB5	0.06	0.09	lasso	1	0.09	2.9e-10	8.8	8.8	1.2e-18	0.99	0.02	0.98	FALSE
45	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EFCAB5	0.08	0.01	blup	79	0.03	1.7e-02	8.2	8.8	1.5e-18	0.92	0.04	0.67	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EFCAB5	0.09	0.12	lasso	5	0.12	3.1e-13	8.6	8.8	2.2e-18	0.91	0.04	0.96	FALSE
19	GTEx	Thyroid	GIT1	0.06	0.08	lasso	5	0.09	3.7e-07	-8.3	8.7	2.6e-18	0.88	0.07	0.93	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	EFCAB5	0.02	0.04	lasso	4	0.04	1.9e-08	8.5	8.7	3.3e-18	0.94	0.05	0.95	FALSE
9	GTEx	Lung	SSH2	0.08	0.05	lasso	6	0.06	2.7e-05	8.7	8.6	1.1e-17	0.89	0.20	0.80	FALSE
27	METSIM	Adipose	CORO6	0.02	0.02	bslmm	314	0.01	1.7e-02	7.6	-8.5	1.8e-17	-0.87	0.13	0.66	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	SSH2	0.25	0.18	lasso	5	0.17	4.8e-16	-8.2	8.5	2.1e-17	0.85	0.70	0.30	FALSE
37	The Cancer Genome Atlas	Colon Adenocarcinoma	EFCAB5	0.06	0.05	blup	79	0.03	5.7e-03	8.5	8.5	2.3e-17	0.91	0.05	0.91	FALSE
6	GTEx	Brain Nucleus accumbens basal ganglia	CORO6	0.11	0.10	lasso	2	0.05	2.2e-02	8.1	-8.5	2.6e-17	-0.87	0.11	0.55	FALSE
50	The Cancer Genome Atlas	Thyroid Carcinoma	ANKRD13B	0.14	0.20	lasso	4	0.19	2.2e-18	-8.2	8.4	3.3e-17	0.82	0.01	0.99	FALSE
20	GTEx	Thyroid	SSH2	0.12	0.17	enet	10	0.18	2.0e-13	-8.2	8.4	4.6e-17	0.84	0.55	0.45	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	CORO6	0.28	0.40	lasso	3	0.39	6.2e-40	-8.2	8.3	1.1e-16	0.82	0.01	0.99	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	EFCAB5	0.07	0.09	enet	16	0.08	4.0e-09	8.4	8.2	1.6e-16	0.86	0.23	0.77	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	EFCAB5	0.11	0.18	enet	13	0.20	5.8e-19	8.5	8.2	1.8e-16	0.95	0.06	0.94	FALSE
48	The Cancer Genome Atlas	Soft Tissue Sarcoma	EFCAB5	0.06	0.07	lasso	2	0.05	8.2e-04	8.5	8.2	2.4e-16	0.91	0.07	0.90	FALSE
29	NTR	Blood	SSH2	0.04	0.04	enet	22	0.05	1.7e-14	-8.6	8.2	2.7e-16	0.84	0.06	0.94	FALSE
31	YFS	Blood	SSH2	0.09	0.07	lasso	7	0.10	1.6e-30	-4.7	8.2	3.0e-16	0.79	0.62	0.38	FALSE
30	YFS	Blood	GIT1	0.11	0.08	lasso	8	0.09	8.7e-27	6.3	-8.2	3.5e-16	-0.78	0.97	0.03	FALSE
22	GTEx	Thyroid	CORO6	0.23	0.36	lasso	5	0.37	1.2e-29	-8.2	8.1	6.3e-16	0.82	0.81	0.19	FALSE
28	METSIM	Adipose	SSH2	0.03	0.03	blup	422	0.02	1.5e-04	-8.6	8.0	9.4e-16	0.92	0.07	0.93	FALSE
7	GTEx	Esophagus Muscularis	SSH2	0.04	0.01	enet	10	0.00	3.3e-01	8.8	8.0	9.6e-16	0.84	0.07	0.88	FALSE
44	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EFCAB5	0.04	0.04	lasso	4	0.05	5.9e-06	8.4	8.0	1.1e-15	0.91	0.06	0.94	FALSE
16	GTEx	Testis	SSH2	0.06	-0.01	enet	12	-0.01	8.6e-01	8.5	7.8	4.7e-15	0.81	0.10	0.44	FALSE
12	GTEx	Skin Sun Exposed Lower leg	ANKRD13B	0.08	0.04	lasso	5	0.06	1.4e-05	-5.5	-7.8	7.9e-15	-0.71	0.13	0.82	FALSE
13	GTEx	Skin Sun Exposed Lower leg	RP11-68I3.4	0.03	0.00	lasso	3	0.00	4.5e-01	-8.4	7.5	5.7e-14	0.75	0.05	0.43	FALSE
36	The Cancer Genome Atlas	Colon Adenocarcinoma	CCDC55	0.15	0.01	blup	64	0.04	1.9e-03	7.9	-7.2	8.2e-13	-0.77	0.03	0.38	FALSE
32	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EFCAB5	0.06	0.08	lasso	2	0.07	1.4e-06	7.1	7.2	8.8e-13	0.84	0.09	0.90	FALSE
3	CommonMind	Brain Pre-frontal Cortex	EFCAB5	0.11	0.18	blup	392	0.17	1.7e-20	8.5	7.0	2.8e-12	0.86	0.30	0.70	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	GIT1	0.06	0.05	blup	47	0.05	5.2e-06	-8.3	6.9	5.1e-12	0.74	0.00	1.00	FALSE
47	The Cancer Genome Atlas	Prostate Adenocarcinoma	EFCAB5	0.04	0.03	enet	10	0.02	6.0e-03	8.3	6.8	9.0e-12	0.74	0.15	0.71	FALSE
5	GTEx	Artery Tibial	BLMH	0.12	0.04	enet	16	0.08	6.7e-07	-3.0	6.8	1.2e-11	0.74	0.32	0.68	FALSE
4	CommonMind	Brain Pre-frontal Cortex	TAOK1	0.06	0.00	bslmm	370	0.02	2.1e-03	-5.5	-6.8	1.4e-11	-0.61	0.12	0.38	FALSE
25	METSIM	Adipose	ANKRD13B	0.04	0.03	lasso	3	0.05	1.4e-07	8.8	-6.7	2.1e-11	-0.86	0.06	0.94	FALSE
49	The Cancer Genome Atlas	Stomach Adenocarcinoma	EFCAB5	0.06	0.02	blup	80	0.02	1.1e-02	8.6	6.7	2.5e-11	0.73	0.03	0.51	FALSE
18	GTEx	Testis	RP11-68I3.4	0.10	0.02	lasso	4	0.03	1.4e-02	-4.3	6.6	4.4e-11	0.45	0.13	0.51	FALSE
26	METSIM	Adipose	BLMH	0.03	0.03	blup	304	0.03	6.0e-05	-5.0	6.5	7.1e-11	0.79	0.58	0.34	FALSE
40	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EFCAB5	0.05	0.02	enet	22	0.02	1.7e-02	8.3	6.3	2.6e-10	0.81	0.06	0.61	FALSE
54	The Cancer Genome Atlas	Thyroid Carcinoma	SLC6A4	0.02	0.03	lasso	3	0.03	2.8e-04	7.0	-6.1	8.4e-10	-0.70	0.06	0.33	FALSE
21	GTEx	Thyroid	TP53I13	0.14	0.16	enet	7	0.14	6.0e-11	-3.8	6.1	9.4e-10	0.63	0.99	0.01	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	TP53I13	0.09	0.08	enet	10	0.10	6.4e-10	-2.7	6.0	1.9e-09	0.61	0.64	0.36	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	CORO6	0.03	0.01	enet	10	0.01	1.7e-03	6.4	-5.9	3.5e-09	-0.59	0.02	0.89	FALSE
17	GTEx	Testis	TP53I13	0.39	0.38	lasso	9	0.38	7.3e-18	-4.3	5.9	3.7e-09	0.42	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ABHD15	0.07	0.03	bslmm	319	0.04	3.4e-05	-3.8	-5.8	8.4e-09	-0.31	0.46	0.03	FALSE
46	The Cancer Genome Atlas	Prostate Adenocarcinoma	BLMH	0.05	0.03	blup	55	0.05	1.1e-05	-5.0	5.6	1.8e-08	0.57	0.92	0.05	FALSE
8	GTEx	Heart Left Ventricle	ANKRD13B	0.13	0.04	lasso	5	0.03	1.5e-02	-2.7	-5.6	2.4e-08	-0.42	0.60	0.24	FALSE
23	GTEx	Thyroid	ANKRD13B	0.23	0.12	lasso	6	0.18	2.3e-13	7.6	5.6	2.4e-08	0.68	0.17	0.83	FALSE
24	METSIM	Adipose	ABHD15	0.07	0.06	lasso	3	0.06	6.1e-09	-4.2	-5.6	2.6e-08	-0.44	0.98	0.02	FALSE
10	GTEx	Lung	ANKRD13B	0.13	0.09	lasso	6	0.08	6.8e-07	-2.7	-5.5	4.9e-08	-0.66	0.37	0.63	FALSE
15	GTEx	Testis	GIT1	0.12	0.17	lasso	2	0.13	2.1e-06	6.4	-5.5	5.0e-08	-0.50	0.50	0.44	FALSE