TWAS hub - DHRS13

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0350	0.0180	3.7e-03	0.013	0.024	0.005	NA	0.011	7.8e-03	5.9e-04	8.1e-02	NA	1.5e-02
2	GTEx	Brain Cerebellum	0.1600	0.0700	5.1e-03	0.050	NA	0.024	NA	0.052	1.4e-02	NA	6.3e-02	NA	1.2e-02
3	YFS	Blood	0.0261	0.0085	5.4e-09	0.028	0.032	0.037	NA	0.036	1.6e-09	1.1e-10	4.1e-12	NA	7.6e-12

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Mouth/teeth dental problems: Bleeding gums	10.6	13.8	18.7	4.2	2.2	4.3
Blood Red Count	9.5	91.6	132.2	10.0	6.5	11.5
Heart disease (siblings)	8.6	10.6	16.3	3.3	2.2	4.0
Multivitamins +/- minerals	7.0	8.8	12.6	-2.7	-3.5	-2.6
Past tobacco smoking	6.5	11.9	13.7	-3.5	-3.7	-3.1
LDL Cholesterol	6.4	10.2	15.7	4.0	0.3	3.8
Ever had stillbirth, spontaneous miscarriage or termination	6.4	6.8	8.8	3.0	2.4	2.4
Illnesses of siblings	5.6	7.8	10.0	-1.9	-3.2	-3.2
Respiratory disease	5.3	11.9	14.2	-3.1	-3.5	-3.8
Smoking status: Previous	5.2	7.7	9.8	2.7	3.1	2.5
Blood Platelet Count	4.9	57.0	141.6	11.9	4.0	3.6
Ever used hormone-replacement therapy (HRT)	4.9	6.3	11.0	-3.3	-1.2	-2.5
Mouth/teeth dental problems	4.8	7.3	10.5	-3.1	-1.2	-3.2
Medication: Ibuprofen (e.g. Nurofen)	4.8	6.1	9.1	-2.5	-3.0	-1.8
Number of children fathered	4.8	5.5	7.4	-1.8	-2.4	-2.7
Severe depression (siblings)	4.4	4.9	6.1	2.5	1.9	2.2
Medication: Atenolol	4.1	5.1	8.9	1.5	2.0	3.0
Asthma	4.1	8.0	9.8	-2.7	-2.6	-3.1
Asthma (self-reported)	4.1	8.1	11.2	-2.6	-2.5	-3.4
Smoking Status	4.0	9.7	13.6	3.7	2.5	3.0
Heart attack	3.9	4.9	8.7	3.0	0.5	2.4
Hearing difficulty/problems: Yes	3.8	5.9	9.5	-2.6	-1.0	-3.1
Ever unenthusiastic/disinterested for a whole week	3.8	4.7	6.0	2.4	1.5	2.4
Ever smoked	3.4	5.9	7.0	2.3	2.6	2.3
Supplements: Fish oil (including cod liver oil)	3.3	4.3	5.8	-2.4	-1.6	-2.2
HbA1C	3.2	3.5	7.7	1.4	1.0	2.8
Mouth/teeth dental problems: Loose teeth	3.2	3.8	5.4	2.3	1.4	2.0
Number of full sisters	3.2	3.9	6.3	-1.6	-1.7	-2.5
High cholesterol (Self-reported)	3.1	5.5	13.4	3.7	-0.7	1.6
Hayfever/allergic rhinitis (self-reported)	3.0	4.0	7.4	-1.6	-1.5	-2.7
Medication: Ramipril	3.0	3.9	4.5	1.8	2.1	2.0
Qualifications: O levels/GCSEs or equivalent	3.0	4.9	7.8	2.3	2.8	1.2
Medication: Gliclazide	3.0	3.4	6.2	2.5	1.5	1.4
Ever depressed for a whole week	3.0	3.7	8.2	2.9	0.7	1.6
Heart attack/myocardial infarction (self-reported)	3.0	3.8	7.0	2.6	0.3	2.1
Prospective memory result	2.9	3.6	6.2	1.7	1.3	2.5
Serious illness, injury or assault to yourself	2.7	3.3	3.8	1.5	1.9	2.0
Medication for cholesterol, blood pressure or diabetes	2.7	4.5	5.2	-1.8	-2.3	-2.2
Worry too long after embarrassment	2.7	4.5	8.9	-3.0	-0.8	-2.0
Blood White Count	2.6	19.6	38.9	-6.2	-2.9	-3.4
Vitamin and mineral supplements	2.6	3.5	7.2	1.4	2.7	1.2
Medication: Simvastatin	2.6	3.9	6.2	2.5	0.9	2.1
Migraine (self-reported)	2.6	3.3	6.4	-2.5	-1.4	-1.3
Ever had prostate specific antigen (PSA) test	2.6	3.0	4.2	-1.6	-2.1	-1.5
Shortness of breath walking on level ground	2.5	3.0	6.2	1.6	0.4	2.5
Medication: Blood pressure	2.4	4.2	6.8	0.9	2.6	2.2
Medication: Seretide 50 evohaler	2.4	2.8	3.9	-1.3	-1.7	-2.0
Waist Hip Ratio (WHR)	2.3	10.5	13.5	3.7	3.2	2.8
Other serious medical condition/disability diagnosed by doctor	2.3	2.9	4.1	1.2	1.8	2.0
Waist circumference	2.3	8.5	12.7	3.1	1.8	3.6
Number of incorrect matches in round	2.3	3.8	7.1	1.0	1.8	2.7
Commuting to job workplace: Walk	2.3	2.5	5.5	1.3	2.4	0.5
Mouth/teeth dental problems: Mouth ulcers	2.3	3.6	4.8	1.9	1.6	2.2
Breast cancer (self-reported)	2.3	2.7	3.6	1.6	1.3	1.9
Cholesterol lowering medication	2.3	3.4	7.5	2.7	-0.7	1.5
High blood pressure (siblings)	2.2	3.1	6.4	0.9	2.5	1.5
Suffer from ‘nerves’	2.2	3.4	6.5	-2.5	-1.5	-1.3
Tinnitus: Yes, now most or all of the time	2.2	2.6	3.8	-0.7	-1.9	-1.9
Mean Putamen Volume	2.1	2.4	3.5	1.9	1.2	1.5
Hayfever, allergic rhinitis or eczema	2.1	4.6	7.7	-1.5	-1.9	-2.8
Sitting height	2.1	14.9	27.2	-5.2	-3.1	-2.8
Impedance of arm (right)	2.1	9.6	13.1	-3.5	-1.9	-3.6
Time employed in main current job	2.1	2.4	5.5	-0.8	-2.3	-1.1
Impedance of arm (left)	2.1	9.8	14.6	-3.8	-1.8	-3.4
Ever highly irritable/argumentative for 2 days	2.1	2.6	4.1	-1.3	-2.0	-1.4
Forced vital capacity (FVC), Best measure	2.1	7.9	9.0	-2.7	-3.0	-2.7
Cardiovascular Disease	2.0	6.6	11.4	2.3	1.8	3.4
Ever had hysterectomy (womb removed)	2.0	2.2	5.6	0.8	2.4	0.6
Allergy	2.0	4.5	8.1	1.3	2.0	2.8
Medication: Cholesterol lowering	2.0	3.2	4.3	2.0	1.2	2.1
Headache pain in last month	2.0	3.5	5.5	-1.9	-2.3	-1.2
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	3.1	1.4	1.8	1.5
Father’s age at death	1.9	2.6	2.9	-1.4	-1.7	-1.7
Gout (self-reported)	1.9	2.6	6.7	-1.0	2.6	0.4
Forced vital capacity (FVC)	1.8	6.9	11.0	-2.1	-3.3	-2.3
Medication: Amlodipine	1.8	2.5	3.4	-1.8	1.5	1.4
Leg fat percentage (right)	1.8	6.3	11.0	2.5	1.3	3.3
Allergy or Eczema	1.7	4.5	6.1	-2.0	-1.9	-2.5
Alcohol intake versus 10 years previously	1.7	2.6	4.1	1.8	0.7	2.0
Birth weight of first child	1.7	3.1	4.1	-1.4	-2.0	-1.8
Comparative body size at age 10	1.7	4.8	6.9	-1.4	-2.6	-2.4
Basal cell carcinoma (self-reported)	1.7	2.0	3.2	1.8	1.3	1.1
Ovarian Cancer	1.6	2.1	5.2	-1.0	-2.3	-0.2
Medication for pain relief, constipation, heartburn	1.6	2.8	5.2	1.3	2.3	1.2
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	3.8	1.2	1.9	0.9
Leg fat percentage (left)	1.6	5.6	9.8	2.3	1.4	3.1
Average weekly beer plus cider intake	1.6	2.3	4.1	-2.0	-1.5	-0.7
BMI	1.5	8.5	16.7	2.6	1.5	4.1
Angina	1.5	2.0	3.5	1.6	0.2	1.9
Osteoarthritis (self-reported)	1.5	1.9	3.0	1.2	1.7	1.1
Vascular/heart problems diagnosed by doctor	1.5	4.0	5.8	-1.6	-2.0	-2.4
Ulcerative Colitis	1.4	2.0	3.5	1.9	1.1	1.1
Lung FEV1/FVC ratio	1.4	7.2	9.1	2.7	3.0	2.3
Townsend deprivation index at recruitment	1.4	1.9	2.4	1.3	1.6	1.3
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	3.8	0.7	0.0	2.0
Chronic bronchitis/emphysema (father)	1.4	1.6	2.6	-1.5	-1.6	-0.4
Worrier / anxious feelings	1.4	2.6	4.5	0.6	1.7	2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	2.8	1.4	1.2	1.7
Angina (self-reported)	1.4	1.8	3.5	1.4	0.3	1.9
Medication: Ibuprofen	1.4	1.7	2.2	-1.5	-1.4	-0.9
Comparative height size at age 10	1.4	7.8	12.8	-3.6	-2.4	-2.2
Wears glasses or contact lenses	1.4	1.6	3.4	-1.8	-0.4	-1.2
Myopia	1.4	2.0	3.0	1.0	1.4	1.7
Hypothyroidism (self reported)	1.3	2.9	7.3	-2.7	-0.6	-1.1
High blood pressure (mother)	1.3	1.8	3.5	0.3	1.9	1.3
Illnesses of mother	1.3	1.7	2.5	-0.8	-1.6	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.3	4.9	-2.1	-2.2	-1.9
Leg fat mass (right)	1.3	5.1	10.1	2.1	1.0	3.2
Commuting to job workplace: Car/motor vehicle	1.3	1.4	3.3	-0.8	-1.8	-0.6
Hypertension (Self-reported)	1.3	3.6	4.9	1.5	1.9	2.2
Friendships satisfaction	1.3	1.6	3.2	-1.0	-1.8	-0.7
Average weekly champagne plus white wine intake	1.3	1.8	2.5	1.2	1.2	1.6
Irritable Bowel Disease (IBD)	1.2	2.9	4.6	1.3	2.1	1.6
Ulcerative Colitis (UC)	1.2	2.3	3.8	1.5	2.0	0.9
Primary Biliary Cirrhosis	1.2	1.7	3.8	-1.1	-1.9	-0.4
Medication: Paracetamol	1.2	1.9	3.5	-1.1	-1.9	-1.0
Medication: Allopurinol	1.2	1.7	3.9	-0.6	2.0	0.9
Age at last live birth	1.2	1.7	2.8	0.5	1.7	1.5
Smoking status: Current	1.2	1.9	4.7	2.2	-0.4	0.9
Leg fat mass (left)	1.2	4.7	9.3	1.9	1.1	3.0
Reaction Time	1.1	2.0	2.6	-1.5	-1.2	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	5.0	-1.5	2.2	0.4
Forced expiratory volume in 1-second (FEV1)	1.1	3.5	4.9	-1.7	-2.2	-1.7
Birth weight	1.1	2.5	3.9	-2.0	-1.2	-1.4
Health satisfaction	1.1	1.4	2.8	1.1	0.4	1.7
Eye problems/disorders: None of the above	1.1	1.2	2.4	0.5	-1.6	-1.0
Illnesses of father: Heart disease	1.1	1.5	3.1	1.8	0.3	1.2
Mineral and other dietary supplements	1.1	1.5	1.8	1.3	1.2	1.1
Age started oral contraceptive pill	1.1	1.4	2.4	1.6	1.0	1.0
Coronary Artery Disease (CAD)	1.0	1.2	2.1	-0.5	-1.4	-1.2
Medication: Co-codamol	1.0	1.2	2.3	1.5	0.3	1.1
Current tobacco smoking	1.0	1.6	3.9	2.0	-0.6	0.7
High blood pressure	1.0	2.7	3.5	1.2	1.7	1.9
Pulse rate	1.0	1.8	4.8	-0.7	0.1	-2.2
Depression (self-reported)	1.0	1.2	2.0	-1.2	0.2	-1.4
Pulse wave reflection index	1.0	1.2	2.1	1.5	-0.2	1.2
Ever taken oral contraceptive pill	1.0	1.1	2.6	0.7	-0.4	1.6
Pack years of smoking	1.0	1.4	3.4	1.8	-0.2	0.9
Intelligence (Savage-Jansen 2018)	0.9	2.8	7.3	2.7	0.4	-1.0
Average weekly spirits intake	0.9	1.1	1.4	-1.2	-0.8	-1.2
Systolic blood pressure, automated reading	0.9	2.7	4.9	0.2	2.2	1.8
Fed-up feelings	0.9	1.7	2.1	-1.4	-1.2	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	4.1	-2.0	1.4	0.4
Had major operations	0.9	1.0	2.4	-0.8	-1.5	-0.0
Family relationship satisfaction	0.9	1.1	2.8	1.7	-0.1	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.5	-0.1	-1.6	-0.8
Impedance of whole body	0.9	4.4	6.6	-2.5	-0.8	-2.6
Depression (Nagel 2018)	0.8	1.2	3.0	-0.9	-1.7	0.1
Alzheimer’s Disease (in mother)	0.8	0.9	2.1	-0.8	-0.1	-1.4
Bipolar Disorder (2011)	0.8	0.8	0.9	0.8	0.9	0.9
Blood Eosinophil Count	0.8	6.2	6.9	-2.4	-2.5	-2.6
Sensitivity / hurt feelings	0.8	1.5	3.3	-1.8	-0.2	-1.0
Relative age of first facial hair	0.8	1.7	2.6	1.6	-0.8	1.3
Body mass index (BMI)	0.8	3.3	5.9	1.9	0.7	2.4
Falls in the last year	0.8	1.0	1.5	0.9	0.9	1.2
Number of live births	0.8	1.2	3.1	-0.3	1.8	0.6
Qualifications: A levels/AS levels or equivalent	0.8	1.8	2.1	1.5	1.4	1.1
Medication: Blood pressure	0.8	1.6	3.9	0.5	0.7	2.0
Commuting to job workplace: Cycle	0.8	1.0	2.9	1.7	0.1	0.2
Neuroticism (Nagel 2018)	0.7	1.7	3.7	-1.9	-0.8	-0.9
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.8	0.6	-0.9	-2.0
Schizophrenia (2014)	0.7	1.5	3.3	1.8	1.1	0.3
Triglycerides	0.7	1.2	2.5	0.8	1.6	0.7
Heel T-Score	0.7	5.4	10.9	-2.3	3.3	-0.2
Diabetes (father)	0.7	0.9	2.6	-1.6	0.0	-0.0
Pack years adult smoking proportion	0.7	1.1	2.6	1.6	-0.3	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	3.0	-0.3	-1.7	-0.2
Standing height	0.7	6.6	9.7	-3.1	-2.9	-1.2
Blood clot in the leg (DVT)	0.7	1.0	2.0	-0.1	-1.0	-1.4
Glaucoma (self-reported)	0.7	0.9	2.4	0.0	1.6	0.4
Exposure to tobacco smoke outside home	0.7	1.0	2.0	0.7	0.7	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.4	1.0	0.2	1.2
Leg pain on walking	0.7	0.8	1.5	1.2	0.8	0.7
Guilty feelings	0.7	1.0	2.6	-1.6	-0.3	0.7
Commuting to job workplace: Public transport	0.7	0.8	1.2	0.8	0.8	1.1
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.7	0.1	-0.9	-1.3
Alzheimer’s Disease (including proxy)	0.6	0.9	1.8	-0.5	-0.7	-1.3
Breast Cancer	0.6	1.4	3.1	1.8	-0.8	0.7
Prostate Cancer	0.6	0.8	1.7	-1.3	0.8	-0.1
Chronotype (morning person)	0.6	1.3	3.3	-0.7	0.4	1.8
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.6	-0.3	1.3	0.4
Medication: Lansoprazole	0.6	0.7	1.9	-0.1	0.1	-1.4
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.4	-0.6	0.6	-1.2
Pulse rate, automated reading	0.6	1.9	3.0	-0.2	1.6	-1.7
Number of operations (self-reported)	0.6	0.8	1.9	0.8	-1.4	0.0
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.4	-0.5	-0.7	-1.2
Supplements: Calcium	0.6	0.7	1.6	1.3	-0.7	0.1
Arm predicted mass (left)	0.6	3.1	6.9	1.5	-0.4	2.6
Schizophrenia vs Biploar Disorder	0.5	0.7	1.4	1.2	0.6	0.7
Age at First Birth	0.5	0.7	1.5	-1.2	-0.3	-0.8
Height	0.5	9.4	18.6	-4.3	-3.0	-0.8
Average weekly fortified wine intake	0.5	0.6	1.2	-1.1	-0.7	-0.3
Relative age voice broke	0.5	0.7	1.9	-0.3	-1.4	-0.3
Age when periods started (menarche)	0.5	1.2	3.0	1.7	0.3	0.7
Qualifications: CSEs or equivalent	0.5	0.6	0.8	0.9	0.5	0.9
Loud music exposure frequency	0.5	0.5	1.1	0.7	0.2	1.0
Heart disease (mother)	0.5	0.6	1.4	-0.5	-0.3	1.2
Whole body fat mass	0.5	2.1	5.0	1.1	0.3	2.2
Arm predicted mass (right)	0.5	2.4	5.8	1.1	-0.4	2.4
Ever had bowel cancer screening	0.5	0.5	1.4	0.3	-1.2	0.4
Alcohol drinker status: Previous	0.5	0.5	0.6	-0.7	0.7	-0.8
HDL Cholesterol	0.4	0.6	1.2	0.8	1.1	-0.2
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.2	-0.2	-1.1	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	0.9	-1.0	-0.9	0.3
Alcohol usually taken with meals	0.4	0.7	1.3	0.3	0.8	1.1
Arm fat mass (right)	0.4	1.5	3.3	1.1	-0.2	1.8
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.7	-1.3	-0.1	-0.7
Body fat percentage	0.4	1.7	3.7	1.0	0.6	1.9
Arm fat-free mass (right)	0.4	1.9	5.0	0.9	-0.4	2.2
Overall health rating	0.4	0.9	1.2	1.1	0.4	1.1
Supplements: Vitamin C	0.4	0.4	0.8	0.4	0.5	0.9
Average weekly red wine intake	0.4	0.6	1.2	-1.1	0.5	-0.5
Handedness (chirality/laterality): Left-handed	0.4	0.4	0.8	-0.9	-0.4	-0.6
Long-standing illness, disability or infirmity	0.4	0.5	1.3	0.1	0.6	1.1
Diabetes diagnosed by doctor	0.4	0.7	1.3	-0.7	0.5	-1.2
Back pain experienced in last month	0.4	0.6	0.9	-0.8	-0.6	-0.9
Arm fat mass (left)	0.4	1.6	3.6	1.1	-0.1	1.9
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	-0.7	1.0	0.0
Medication: Paracetamol	0.4	0.6	1.3	-0.5	-1.1	-0.4
Medication: Atorvastatin	0.4	0.5	0.9	0.9	-0.7	0.3
Illnesses of father: High blood pressure	0.4	0.5	1.1	-1.0	-0.2	0.6
Alcohol drinker status: Never	0.4	0.5	0.8	-0.9	-0.9	0.3
Arm fat-free mass (left)	0.4	2.3	4.9	1.3	-0.4	2.2
Irritability	0.4	0.7	2.0	-0.4	-1.4	-0.0
Pain experienced in last month	0.4	0.6	1.5	0.3	1.2	0.5
Schizophrenia (2018)	0.3	0.6	1.5	1.2	0.7	0.1
Alzheimer’s Disease (in father)	0.3	0.3	0.8	0.4	-0.9	0.1
Crohns Disease (2017)	0.3	0.7	1.0	-0.0	1.0	1.0
Neuroticism (2016)	0.3	0.4	0.7	-0.9	0.6	0.1
Neuroticism	0.3	0.7	1.1	-1.0	-0.8	-0.4
Medication: Metformin	0.3	0.4	0.7	-0.6	-0.2	-0.8
Diabetes (mother)	0.3	0.4	0.8	0.3	0.5	0.9
Leg fat-free mass (left)	0.3	1.7	4.1	-0.5	-2.0	0.8
Taking other prescription medications	0.3	0.5	0.7	-0.9	0.7	-0.5
Stomach or abdominal pain in last month	0.3	0.4	0.9	0.5	-0.3	1.0
Leg predicted mass (left)	0.3	1.5	3.8	-0.4	-1.9	0.8
Qualifications: None of the above	0.3	0.7	1.3	-0.9	-1.1	-0.2
Diabetes (self-reported)	0.3	0.5	0.9	-0.1	1.0	-0.7
Fluid intelligence score	0.3	0.5	1.2	0.2	-0.6	-1.1
Neuroticism score	0.3	0.7	1.5	-1.2	-0.6	-0.3
Weight	0.3	1.5	3.9	0.5	-0.6	2.0
Arm fat percentage (right)	0.3	1.2	2.4	1.1	0.3	1.6
Trunk fat-free mass	0.3	1.5	3.7	0.4	-0.8	1.9
Hip circumference	0.3	1.3	3.7	0.4	-0.0	1.9
Hair/balding pattern: Pattern 3	0.3	0.4	0.8	0.9	0.3	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.0	-1.0	0.3	0.3
Lung cancer (father)	0.3	0.3	0.6	0.5	0.2	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.6	-0.8	-0.5	-0.2
Mean time to correctly identify matches	0.3	0.6	1.1	-0.6	-0.4	-1.1
Alcohol intake frequency.	0.3	0.6	1.3	0.3	-0.7	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.8	-0.4	-0.3	-0.9
Leg fat-free mass (right)	0.3	1.7	4.1	-0.8	-2.0	0.5
Arm fat percentage (left)	0.3	1.1	2.6	0.8	0.2	1.6
Qualifications: nursing, teaching	0.3	0.5	0.8	-0.4	0.7	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.3	-0.7	-0.3	-1.1
Whole body water mass	0.3	1.4	2.7	0.3	-1.2	1.6
Leg predicted mass (right)	0.3	1.6	4.0	-0.7	-2.0	0.5
Hearing aid user	0.3	0.3	0.4	-0.5	0.5	-0.6
Financial situation satisfaction	0.3	0.3	0.6	-0.8	-0.5	-0.3
Basal metabolic rate	0.3	1.5	3.0	0.2	-1.2	1.7
Fractured/broken bones in last 5 years	0.3	0.4	1.0	1.0	0.3	-0.2
Depressed Affect (Nagel 2018)	0.2	0.3	0.7	-0.4	-0.8	-0.5
Crohns Disease (2012)	0.2	0.3	0.5	-0.7	-0.5	-0.6
Fasting Glucose	0.2	0.2	0.6	0.1	-0.1	0.8
Rheumatoid Arthritis	0.2	0.3	0.6	0.1	-0.8	-0.4
Systolic Blood Pressure	0.2	1.0	1.2	-1.1	0.8	1.1
Number of treatments/medications taken	0.2	0.3	0.4	-0.4	0.6	0.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	-0.6	-0.1	-0.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.4	-0.1	-0.7	-0.6
Medication: Levothyroxine sodium	0.2	0.3	0.8	-0.9	0.3	-0.3
Trunk fat mass	0.2	0.9	2.5	0.4	-0.1	1.6
Hearing difficulty/problems with background noise	0.2	0.4	1.1	0.0	1.1	-0.1
Hair/balding pattern: Pattern 2	0.2	0.3	0.9	-0.3	-0.1	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.8	0.3	0.4	0.9
Pulse wave Arterial Stiffness index	0.2	0.2	0.7	-0.2	0.3	-0.8
Trunk predicted mass	0.2	1.4	3.3	0.4	-0.8	1.8
Length of working week for main job	0.2	0.2	0.3	0.5	-0.5	-0.0
Peak expiratory flow (PEF)	0.2	0.5	1.3	-0.4	-0.3	1.1
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	0.6	-0.0	0.6
Number of full brothers	0.2	0.3	0.4	0.3	0.6	0.6
Wheeze or whistling in the chest in last year	0.2	0.4	0.5	0.7	-0.7	0.3
Age at first live birth	0.2	0.3	0.7	0.3	0.4	0.8
Chest pain or discomfort	0.2	0.2	0.5	0.4	-0.1	0.7
Illnesses of siblings: Diabetes	0.2	0.3	0.8	-0.9	0.2	-0.0
Whole body fat-free mass	0.2	1.4	2.6	0.2	-1.2	1.6
Mood swings	0.2	0.3	0.5	-0.4	-0.7	0.4
Medication for cholesterol	0.2	0.4	0.4	-0.6	0.6	-0.6
Osteoporosis (self-reported)	0.2	0.3	0.3	0.5	0.6	-0.5
Miserableness	0.2	0.3	0.7	0.0	0.6	0.8
Diastolic blood pressure, automated reading	0.2	0.6	1.3	-0.1	0.7	-1.1
Unable to work because of sickness or disability	0.2	0.3	0.3	-0.4	0.6	0.5
Bipolar Disorder (2018)	0.1	0.2	0.3	-0.2	-0.4	-0.6
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	0.8	0.3	-0.3
Major Depression (MDD)	0.1	0.1	0.2	-0.1	-0.3	0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	0.1	0.1	-0.7
Lung FVC	0.1	0.4	0.6	0.1	-0.8	-0.8
Hair Pigment	0.1	1.9	4.0	2.0	0.9	0.9
Hand grip strength (left)	0.1	0.3	0.6	0.6	0.2	0.8
Medication for hormone replacement therapy	0.1	0.2	0.3	-0.2	-0.6	-0.3
Supplements: Zinc	0.1	0.1	0.2	0.2	-0.2	0.5
Impedance of leg (right)	0.1	0.4	1.0	-0.2	1.0	-0.2
Trunk fat percentage	0.1	0.6	1.6	0.4	0.0	1.3
Hand grip strength (right)	0.1	0.2	0.4	0.6	-0.1	0.6
Supplements: Glucosamine	0.1	0.1	0.2	0.1	0.4	0.4
Impedance of leg (left)	0.1	0.7	2.0	-0.2	1.4	-0.1
Nervous feelings	0.1	0.1	0.3	-0.2	0.5	0.1
Had other major operations	0.1	0.1	0.3	0.0	-0.5	0.1
Financial difficulties in last 2 years	0.1	0.2	0.4	-0.3	-0.7	-0.1
Happiness	0.1	0.2	0.2	-0.3	-0.5	-0.5
Noisy workplace	0.1	0.2	0.2	-0.3	-0.5	0.3
Exposure to tobacco smoke at home	0.1	0.2	0.5	-0.2	0.1	0.7
Breastfed as a baby	0.1	0.1	0.1	0.4	-0.3	0.3
Tense / ‘highly strung’	0.1	0.1	0.2	-0.4	0.1	0.4
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	0.1	-0.6	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.1	-0.3	0.0	0.4
Pulse wave peak to peak time	0.1	0.2	0.3	-0.1	-0.5	0.5
Emphysema/chronic bronchitis	0.1	0.1	0.3	-0.1	0.3	-0.6
Medication: Omeprazole	0.1	0.1	0.2	-0.1	0.1	-0.4
Medication: Aspirin	0.1	0.2	0.4	0.6	0.3	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	-0.7	-0.4	-0.0
Eye problems/disorders: Cataract	0.1	0.1	0.2	0.5	0.4	0.3
Medication: Aspirin	0.1	0.1	0.1	0.4	0.2	0.2
Illnesses of father: None of the above (group 1)	0.1	0.1	0.4	0.6	0.0	-0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.5	0.2	-0.0	-0.7
Medication: Bendroflumethiazide	0.1	0.2	0.5	-0.2	0.4	0.7
Risk taking	0.1	0.2	0.3	0.4	-0.2	-0.6
Worry (Nagel 2018)	0.0	0.1	0.3	-0.5	0.1	0.1
Body Mass Index (BMI) (2010)	0.0	0.1	0.1	-0.3	-0.2	0.2
Lupus	0.0	0.1	0.1	-0.2	0.2	-0.3
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.2	-0.2	0.2
Tanning	0.0	0.3	0.9	0.9	-0.0	0.2
Maternal smoking around birth	0.0	0.1	0.1	0.3	-0.1	0.3
Had menopause	0.0	0.1	0.1	-0.3	-0.1	0.2
Pain all over the body in last month	0.0	0.0	0.1	0.1	0.1	0.2
Mouth/teeth dental problems: Dentures	0.0	0.1	0.1	0.2	0.2	-0.3
Qualifications: College or University degree	0.0	0.0	0.0	0.0	-0.1	-0.1
Neck or shoulder pain in last month	0.0	0.0	0.0	0.0	-0.1	0.1
Knee pain experienced in last month	0.0	0.1	0.2	-0.1	-0.4	-0.1
Loneliness, isolation	0.0	0.0	0.1	0.2	-0.3	-0.0
Number of self-reported non-cancer illnesses	0.0	0.1	0.1	-0.4	0.2	0.1
Mother’s age at death	0.0	0.0	0.1	0.3	0.1	-0.1
Medication: Lisinopril	0.0	0.0	0.1	-0.2	-0.3	0.0

Hub : Genes

DHRS13

Models

Trait associations