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chr19:316,040-2,862,806

Best TWAS P=7.44e-32 · Best GWAS P=2.33e-25 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
55	The Cancer Genome Atlas	Thyroid Carcinoma	CNN2	0.09	0.03	blup	63	0.07	5.4e-07	-10.4	-11.7	7.4e-32	0.74	0.00	1.00	TRUE
2	GTEx	Adipose Subcutaneous	CNN2	0.12	0.00	enet	3	0.00	6.4e-01	-10.4	-10.8	2.3e-27	0.98	0.00	0.98	TRUE
43	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ABCA7	0.05	0.02	blup	71	0.04	4.7e-05	-6.2	-9.6	8.5e-22	0.28	0.44	0.04	TRUE
32	GTEx	Whole Blood	AC011558.5	0.15	0.02	enet	22	0.02	1.2e-02	-7.2	-8.8	8.7e-19	0.36	0.08	0.39	TRUE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	ABCA7	0.09	0.03	lasso	7	0.03	4.5e-04	-6.2	-8.7	3.1e-18	0.29	0.44	0.03	TRUE
13	GTEx	Breast Mammary Tissue	POLR2E	0.39	0.06	lasso	8	0.16	2.1e-08	4.3	-8.4	4.8e-17	-0.03	0.48	0.02	TRUE
5	GTEx	Artery Aorta	POLR2E	0.36	0.10	lasso	5	0.30	3.7e-17	-4.0	-8.2	3.4e-16	0.04	0.99	0.00	TRUE
9	GTEx	Brain Cerebellar Hemisphere	ABCA7	0.46	0.02	enet	52	0.06	1.2e-02	-2.9	-7.9	2.3e-15	0.35	0.06	0.07	TRUE
10	GTEx	Brain Cerebellum	ABCA7	0.46	0.23	lasso	8	0.19	3.0e-06	-7.2	-7.3	3.4e-13	0.44	0.26	0.04	TRUE
39	The Cancer Genome Atlas	Breast Invasive Carcinoma	AP3D1	0.01	0.01	blup	52	0.01	5.4e-03	5.4	-6.8	1.1e-11	0.01	0.00	0.90	TRUE
41	The Cancer Genome Atlas	Colon Adenocarcinoma	GRIN3B	0.11	0.01	enet	8	0.06	2.3e-04	5.0	-6.5	8.7e-11	0.22	0.10	0.06	TRUE
1	CommonMind	Brain Pre-frontal Cortex	CNN2	0.14	0.07	bslmm	472	0.08	1.2e-09	-10.4	-10.7	1.3e-26	0.81	0.00	1.00	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	CNN2	0.05	0.04	blup	63	0.03	2.0e-04	-8.5	-10.6	4.7e-26	0.63	0.01	0.92	FALSE
15	GTEx	Cells Transformed fibroblasts	CNN2	0.22	0.18	lasso	2	0.16	2.7e-12	-10.4	-10.4	2.0e-25	1.00	0.00	1.00	FALSE
8	GTEx	Brain Caudate basal ganglia	TMEM259	0.34	0.14	lasso	7	0.07	4.3e-03	-10.4	-9.8	8.1e-23	0.96	0.00	0.91	FALSE
16	GTEx	Cells Transformed fibroblasts	AC011558.5	0.27	0.05	enet	30	0.11	1.5e-08	-10.4	-9.5	3.2e-21	0.73	0.00	1.00	FALSE
30	GTEx	Thyroid	AC011558.5	0.34	0.10	lasso	9	0.14	1.0e-10	-8.5	-9.3	1.1e-20	0.69	0.02	0.98	FALSE
3	GTEx	Adipose Subcutaneous	AC011558.5	0.19	0.01	enet	7	0.01	5.1e-02	-7.2	-9.1	1.3e-19	0.65	0.07	0.90	FALSE
51	The Cancer Genome Atlas	Prostate Adenocarcinoma	POLR2E	0.06	0.00	blup	53	0.03	2.3e-04	-6.8	-8.7	4.0e-18	0.08	0.01	0.87	FALSE
29	GTEx	Thyroid	CNN2	0.22	0.11	lasso	4	0.09	2.1e-07	-8.5	-8.7	4.1e-18	0.69	0.09	0.90	FALSE
21	GTEx	Esophagus Muscularis	AC011558.5	0.26	0.00	enet	32	0.02	1.4e-02	-10.4	-8.6	7.9e-18	0.49	0.00	0.96	FALSE
27	GTEx	Skin Sun Exposed Lower leg	ABCA7	0.30	0.14	enet	31	0.23	4.1e-19	-7.6	-8.4	6.2e-17	0.52	1.00	0.00	FALSE
7	GTEx	Artery Tibial	POLR2E	0.35	0.26	enet	19	0.27	2.5e-21	-6.2	-8.2	3.2e-16	0.06	1.00	0.00	FALSE
11	GTEx	Brain Cerebellum	HMHA1	0.45	0.07	lasso	8	0.04	1.9e-02	-7.3	-8.2	3.3e-16	0.10	0.06	0.05	FALSE
18	GTEx	Esophagus Muscularis	CNN2	0.38	0.03	lasso	9	0.08	1.9e-05	-10.4	-8.1	4.9e-16	0.68	0.00	0.99	FALSE
42	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GRIN3B	0.05	0.00	blup	69	0.01	8.7e-03	-8.5	-8.0	1.3e-15	0.56	0.01	0.25	FALSE
25	GTEx	Nerve Tibial	POLR2E	0.25	0.06	lasso	4	0.13	1.6e-09	-6.2	-7.9	3.7e-15	0.05	0.70	0.01	FALSE
35	YFS	Blood	CNN2	0.26	0.05	bslmm	341	0.14	4.3e-45	4.7	-7.8	7.6e-15	0.35	1.00	0.00	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	ABCA7	0.10	0.06	lasso	2	0.05	8.1e-06	-7.4	-7.7	1.8e-14	0.12	0.70	0.03	FALSE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	POLR2E	0.06	0.02	blup	53	0.02	4.2e-03	-4.0	-7.7	1.9e-14	0.21	0.01	0.22	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	POLR2E	0.29	0.27	lasso	4	0.29	6.6e-38	-7.4	-7.5	5.1e-14	0.10	1.00	0.00	FALSE
28	GTEx	Testis	HMHA1	0.26	0.15	lasso	2	0.14	1.1e-06	-7.3	7.3	2.0e-13	-0.11	0.92	0.00	FALSE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	GRIN3B	0.03	0.02	blup	70	0.01	5.6e-04	5.0	-7.3	3.1e-13	0.29	0.27	0.06	FALSE
24	GTEx	Nerve Tibial	ABCA7	0.20	0.06	lasso	5	0.05	1.3e-04	-7.2	-7.2	5.0e-13	0.41	0.85	0.05	FALSE
20	GTEx	Esophagus Muscularis	POLR2E	0.38	0.18	enet	38	0.20	3.9e-12	-6.2	-7.1	9.0e-13	0.07	1.00	0.00	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HMHA1	0.06	0.06	lasso	2	0.05	3.1e-06	-6.2	-6.6	3.2e-11	0.11	0.87	0.00	FALSE
48	The Cancer Genome Atlas	Lung Adenocarcinoma	ABCA7	0.06	0.03	blup	71	0.04	3.9e-05	1.7	-6.5	8.7e-11	0.17	0.92	0.00	FALSE
26	GTEx	Prostate	TMEM259	0.32	0.01	lasso	7	0.05	2.8e-02	4.7	-6.3	2.3e-10	0.34	0.07	0.16	FALSE
12	GTEx	Breast Mammary Tissue	ABCA7	0.20	0.04	lasso	3	0.08	4.6e-05	-7.6	-6.1	1.1e-09	0.44	0.07	0.60	FALSE
14	GTEx	Breast Mammary Tissue	TMEM259	0.21	0.06	enet	23	0.08	9.5e-05	5.9	-6.1	1.2e-09	0.22	0.12	0.20	FALSE
38	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	GPX4	0.08	0.01	lasso	7	0.02	4.7e-03	5.0	6.0	1.9e-09	0.10	0.11	0.03	FALSE
31	GTEx	Whole Blood	POLR2E	0.10	0.00	enet	21	0.00	2.3e-01	1.4	-5.7	1.1e-08	0.17	0.05	0.04	FALSE
37	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AP3D1	0.05	0.00	blup	49	0.02	1.7e-02	5.4	-5.7	1.2e-08	-0.02	0.00	0.85	FALSE
36	YFS	Blood	POLR2E	0.20	0.13	bslmm	337	0.16	7.8e-50	5.0	5.6	1.8e-08	-0.17	1.00	0.00	FALSE
52	The Cancer Genome Atlas	Stomach Adenocarcinoma	AP3D1	0.09	0.07	lasso	5	0.08	3.2e-06	5.4	-5.5	3.6e-08	-0.03	0.00	1.00	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	AP3D1	0.06	0.05	enet	7	0.04	5.7e-05	5.4	-5.5	4.7e-08	-0.03	0.00	1.00	FALSE
44	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AP3D1	0.04	0.04	lasso	2	0.04	6.1e-05	5.4	-5.4	5.7e-08	-0.04	0.00	0.99	FALSE
54	The Cancer Genome Atlas	Thyroid Carcinoma	AP3D1	0.05	0.05	lasso	3	0.04	1.0e-04	5.4	-5.4	5.7e-08	-0.04	0.00	0.99	FALSE
17	GTEx	Esophagus Mucosa	AP3D1	0.18	0.21	lasso	3	0.21	2.4e-14	5.0	-5.4	8.0e-08	-0.02	0.01	0.99	FALSE
4	GTEx	Artery Aorta	AP3D1	0.27	0.12	lasso	3	0.13	1.3e-07	5.0	-5.3	8.6e-08	-0.02	0.00	0.99	FALSE
22	GTEx	Lung	AP3D1	0.14	0.11	lasso	3	0.12	1.6e-09	5.4	-5.3	1.1e-07	-0.03	0.00	1.00	FALSE
6	GTEx	Artery Tibial	AP3D1	0.17	0.16	lasso	3	0.16	2.1e-12	5.4	-5.3	1.5e-07	-0.04	0.00	1.00	FALSE
19	GTEx	Esophagus Muscularis	AP3D1	0.32	0.24	lasso	3	0.24	5.7e-15	5.4	-5.2	1.5e-07	-0.03	0.00	1.00	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	AP3D1	0.39	0.40	enet	12	0.43	8.8e-60	5.4	-5.2	2.1e-07	-0.02	0.00	1.00	FALSE
23	GTEx	Muscle Skeletal	AP3D1	0.11	0.07	lasso	5	0.07	2.9e-07	5.4	-5.2	2.6e-07	-0.04	0.00	1.00	FALSE