TWAS hub - GRIN3B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0343	0.0157	6.6e-04	0.020	0.014	0.006	NA	0.014	5.1e-05	5.6e-04	1.4e-02	NA	6.3e-04
2	TCGA	Colon Adenocarcinoma	0.1130	0.0480	7.3e-04	0.009	0.054	0.060	NA	0.053	9.3e-02	4.7e-04	2.3e-04	NA	5.0e-04
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0458	0.0245	7.5e-03	-0.002	0.014	-0.002	NA	-0.002	7.4e-01	8.7e-03	6.6e-01	NA	5.5e-01
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0670	0.0370	6.4e-03	0.013	0.029	0.010	NA	0.019	5.7e-02	9.0e-03	7.9e-02	NA	2.6e-02
5	TCGA	Lung Squamous Cell Carcinoma	0.0363	0.0181	3.3e-03	0.027	0.025	0.005	NA	0.014	4.3e-04	7.5e-04	7.7e-02	NA	8.9e-03
6	TCGA	Prostate Adenocarcinoma	0.0388	0.0207	9.9e-03	0.004	-0.001	0.017	NA	0.000	1.1e-01	4.6e-01	6.6e-03	NA	3.2e-01
7	TCGA	Thyroid Carcinoma	0.0940	0.0330	3.8e-06	0.053	0.073	0.049	NA	0.056	7.1e-06	1.4e-07	1.4e-05	NA	3.7e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Heel bone mineral density (BMD) T-score, automated (right)	4.4	10.1	16.1	-4.0	-3.9	-2.4	-2.9	-3.6	-2.1	-2.9
Heel bone mineral density (BMD) T-score, automated (left)	4.3	9.6	16.7	-4.1	-3.4	-1.3	-2.2	-4.1	-0.8	-4.0
Number of full brothers	4.2	5.3	7.5	-2.6	-2.7	-2.5	-2.6	-2.5	-0.8	-1.7
Blood White Count	4.0	30.0	63.8	-7.3	-6.5	-8.0	-3.9	-4.5	-2.9	-2.8
Mean Putamen Volume	3.5	4.0	6.7	-2.2	-2.6	-1.6	-2.3	-2.2	-0.9	-1.6
Financial situation satisfaction	2.8	3.5	5.7	0.6	2.4	2.2	2.3	2.4	1.7	0.1
Bilateral oophorectomy (both ovaries removed)	2.3	2.7	6.2	-0.5	-0.9	1.5	-1.6	-2.2	1.4	-2.5
Tense / ‘highly strung’	2.3	3.8	8.4	1.2	2.7	-0.0	2.9	2.4	1.2	1.2
High blood pressure (mother)	2.2	3.0	4.6	-2.1	-1.9	-1.3	-1.7	-1.4	-1.9	-1.6
Primary Biliary Cirrhosis	2.0	2.8	5.7	2.1	1.2	0.3	1.4	1.4	2.4	2.0
Number of operations (self-reported)	2.0	3.0	12.9	1.7	1.8	3.6	0.9	0.6	0.6	-0.5
Chronotype (morning person)	1.9	4.3	9.8	-3.1	-1.5	-2.7	0.0	-2.2	-1.4	-2.0
Medication: Ramipril	1.9	2.4	4.0	-1.8	-1.3	0.8	-1.4	-1.5	-1.8	-2.0
Emphysema/chronic bronchitis	1.8	2.0	4.5	1.7	1.1	1.1	1.0	1.2	2.1	1.3
Supplements: Vitamin C	1.8	2.1	7.4	1.1	-0.0	-2.7	1.1	1.2	-0.8	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.7	7.4	-2.2	-2.7	-2.3	-1.3	-0.9	-0.9	-2.3
Diabetes (father)	1.6	2.0	4.5	1.8	0.8	0.6	0.6	2.1	-0.9	2.1
Severe depression (siblings)	1.6	1.8	3.3	-1.1	-1.8	-0.4	-1.0	-1.8	-0.9	-1.8
Time employed in main current job	1.6	1.8	6.0	-0.7	-2.4	-0.6	-1.6	-0.6	-1.6	-0.4
Medication: Amlodipine	1.6	2.2	4.4	-2.1	-1.7	-1.2	-1.2	-1.6	-0.9	-1.3
Supplements: Calcium	1.6	1.8	2.9	1.0	1.3	-0.8	1.6	1.7	1.0	1.7
Heel T-Score	1.5	12.3	21.3	-3.1	-4.6	0.6	-4.3	-4.4	-0.6	-4.1
Taking other prescription medications	1.5	2.2	8.2	1.2	1.2	2.9	1.5	1.4	0.1	-0.7
Hair/balding pattern: Pattern 2	1.5	1.9	6.4	1.4	1.3	2.5	0.8	0.9	1.3	0.5
Illnesses of mother	1.5	1.9	3.7	1.0	1.8	0.1	1.4	1.4	1.2	1.9
Family relationship satisfaction	1.5	1.8	4.6	0.3	1.6	1.4	2.1	0.7	1.2	-1.1
Basal cell carcinoma (self-reported)	1.5	1.7	4.6	-1.0	-2.2	-0.7	-1.7	-1.1	-0.9	-1.0
Alzheimer’s Disease (including proxy)	1.4	2.0	6.2	2.5	1.3	1.5	-0.0	-0.6	1.9	-0.4
Illnesses of father: Heart disease	1.4	1.9	6.8	0.5	1.1	2.6	0.7	0.7	2.1	0.0
Mother’s age at death	1.4	1.7	4.4	-1.1	-1.4	-2.1	-0.8	-0.7	-1.7	-0.6
Qualifications: CSEs or equivalent	1.3	1.8	3.3	-1.8	-0.5	1.4	-0.7	-1.3	-1.1	-1.8
Multivitamins +/- minerals	1.3	1.7	5.0	-2.2	-0.3	-0.6	-0.3	-1.4	-0.8	-1.8
Had menopause	1.3	1.6	4.0	0.9	1.4	1.1	1.0	1.5	-2.0	0.6
Medication: Seretide 50 evohaler	1.3	1.5	3.9	-0.8	-0.5	2.0	-0.9	-1.3	-0.8	-1.7
Mineral and other dietary supplements	1.3	1.8	4.8	1.9	1.0	2.2	-0.0	0.4	1.1	1.3
Medication: Gliclazide	1.3	1.5	3.9	1.5	1.3	2.0	0.4	0.3	1.5	0.3
Hypothyroidism (self reported)	1.2	2.8	7.5	-1.7	-1.8	-0.3	-2.7	-2.0	0.1	-1.3
Hayfever, allergic rhinitis or eczema	1.2	2.7	7.2	-0.6	1.4	-0.4	2.7	2.2	-2.0	-0.1
Pain all over the body in last month	1.2	1.2	4.5	-0.7	-0.0	-1.9	-0.0	-0.3	-2.1	-0.1
Hair/balding pattern: Pattern 4	1.2	2.8	8.0	-2.5	-1.2	-0.7	0.0	-1.0	-1.6	-2.8
Birth weight of first child	1.2	2.2	7.7	1.6	1.1	2.8	0.2	1.0	1.7	0.1
High blood pressure (siblings)	1.2	1.7	4.9	-0.9	-2.1	0.1	-2.2	-1.0	0.1	-1.0
Exposure to tobacco smoke outside home	1.2	1.6	3.6	-1.2	-0.9	1.1	-0.5	-1.8	-0.9	-1.9
Wheeze or whistling in the chest in last year	1.2	2.2	8.8	1.7	1.6	3.0	0.6	0.6	0.3	0.0
Eye problems/disorders: None of the above	1.2	1.4	3.6	-1.0	-0.8	-1.9	-1.0	-1.5	1.1	0.4
Medication: Allopurinol	1.2	1.6	4.1	0.2	0.6	1.1	1.7	1.0	2.0	-1.1
Comparative height size at age 10	1.2	6.6	11.4	3.1	2.7	1.5	1.8	3.2	1.6	3.4
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	4.8	-1.6	-0.2	-0.1	0.2	-1.0	-1.4	-2.2
Eye problems/disorders: Cataract	1.2	1.4	2.2	1.4	1.2	1.4	1.5	1.5	-0.0	-0.5
Osteoporosis (self-reported)	1.2	1.5	3.2	0.9	1.1	1.3	1.8	1.7	-0.8	-0.0
Supplements: Fish oil (including cod liver oil)	1.2	1.6	3.0	-1.7	-1.1	-1.7	-0.5	-0.5	-1.5	-1.0
Respiratory disease	1.1	2.5	6.8	1.1	2.0	2.6	1.7	1.3	0.8	-0.4
Average weekly spirits intake	1.1	1.4	4.0	-0.4	-1.7	0.4	-2.0	-1.4	0.0	-0.7
Had other major operations	1.1	1.3	3.3	0.3	-0.3	1.8	-0.3	-0.1	-1.8	-1.6
Mouth/teeth dental problems	1.1	1.7	3.3	1.3	1.4	-0.4	0.7	1.0	1.8	1.8
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	4.7	-0.6	1.6	-1.4	2.2	1.0	-0.0	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.1	-1.4	-0.8	-0.1	-0.9	-1.8	-0.0	-1.7
Ever depressed for a whole week	1.1	1.4	5.6	-0.8	1.4	-1.1	2.4	0.5	0.0	-0.2
Blood Eosinophil Count	1.0	7.4	17.6	2.8	4.2	1.0	3.6	2.8	1.4	1.8
Allergy or Eczema	1.0	2.5	9.6	-1.0	0.6	-0.4	2.1	1.3	-3.1	-0.8
Maternal smoking around birth	1.0	1.4	4.0	1.5	0.8	2.0	0.2	0.8	1.6	0.0
Supplements: Glucosamine	1.0	1.3	2.4	-1.4	-1.4	-0.2	-0.5	0.1	-1.5	-1.6
Allergy	1.0	2.3	6.0	0.5	-1.3	-0.7	-2.4	-2.0	1.8	0.6
Health satisfaction	1.0	1.3	2.5	-1.6	0.4	1.4	0.4	-1.5	-0.1	-1.4
Qualifications: College or University degree	1.0	3.2	8.0	-0.7	-2.8	-1.4	-2.3	-2.3	-0.2	-1.2
Leg pain on walking	1.0	1.3	4.9	-1.5	-0.3	-0.5	0.9	-0.5	-0.5	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	3.4	0.7	0.9	-0.7	1.4	1.8	0.5	0.8
Friendships satisfaction	1.0	1.3	2.7	1.2	1.5	0.8	1.7	0.5	1.2	-0.6
Pack years of smoking	1.0	1.4	2.1	-0.2	-1.4	-0.1	-1.4	-1.4	-1.3	-1.3
Verbal and Numeric Reasoning (VNR)	0.9	2.1	7.7	1.9	0.6	0.8	0.5	0.8	2.8	1.1
Ever used hormone-replacement therapy (HRT)	0.9	1.1	2.7	0.8	0.7	1.4	-0.4	0.7	-1.7	1.1
Stomach or abdominal pain in last month	0.9	1.2	3.3	-0.8	-0.5	-1.0	-1.4	-1.8	0.6	-0.9
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.9	-1.0	1.0	0.4	2.0	0.4	0.5	-1.1
Hair/balding pattern: Pattern 3	0.9	1.4	5.1	-0.8	-1.2	-2.2	-0.6	-0.9	0.9	-0.8
Prospective memory result	0.9	1.1	2.6	0.2	1.1	1.1	1.2	1.1	-1.6	-0.1
Lung cancer (father)	0.9	1.1	5.3	0.0	-0.2	-1.4	-0.0	-0.3	-2.3	-0.2
Length of working week for main job	0.9	1.0	2.2	-1.0	-0.6	-1.5	0.1	-1.3	0.3	-1.4
Had major operations	0.9	1.1	1.8	0.8	1.3	0.8	1.1	1.2	1.3	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	2.4	-0.3	0.0	1.3	0.0	-0.7	1.6	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.7	-1.3	-1.3	-1.4	-0.7	-0.9	-1.7	-0.4
High cholesterol (Self-reported)	0.9	1.5	2.3	-1.5	-1.3	-0.4	-1.1	-1.3	-1.2	-1.4
Medication: Lisinopril	0.9	1.2	3.5	0.6	-0.8	1.9	-1.3	-0.4	0.8	-1.3
Average weekly beer plus cider intake	0.9	1.4	4.9	-0.3	0.2	2.2	-0.2	-0.2	-1.0	-1.8
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.2	0.8	1.0	0.2	1.2	1.5	0.4	1.1
Unable to work because of sickness or disability	0.9	1.1	3.8	-0.8	-1.0	0.2	-1.9	-1.4	-0.4	-0.6
Alzheimer’s Disease (in mother)	0.8	0.9	2.3	1.5	0.5	1.5	-0.1	-0.0	1.3	-0.2
Crohns Disease (2017)	0.8	1.7	5.5	-0.8	0.7	-0.6	1.2	1.5	-1.1	2.3
Irritable Bowel Disease (IBD)	0.8	1.8	6.4	-0.7	1.0	-1.2	1.5	1.1	0.2	2.5
Ulcerative Colitis (UC)	0.8	1.5	2.7	0.2	1.5	-0.5	1.6	0.4	1.5	1.6
Diabetes (mother)	0.8	1.0	1.7	-1.2	-0.9	-0.3	-0.3	-1.1	-1.3	-1.3
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	3.3	0.8	0.1	1.8	0.4	0.5	-0.5	-1.0
Impedance of arm (right)	0.8	3.6	5.3	2.1	1.8	2.3	1.3	1.7	2.1	1.8
Father’s age at death	0.8	1.0	1.9	-0.4	-1.1	-1.4	-1.4	-0.2	-1.2	0.5
Noisy workplace	0.8	1.0	2.1	-1.3	-0.2	1.4	-0.0	0.3	-1.3	-1.2
Impedance of arm (left)	0.8	3.5	4.9	1.9	1.9	2.1	1.2	1.6	2.2	2.1
Breastfed as a baby	0.8	0.9	3.3	-0.0	-0.5	1.8	-0.1	-0.6	0.1	-1.6
Peak expiratory flow (PEF)	0.8	1.9	4.3	-1.5	-1.2	-0.8	-0.1	-0.7	-2.0	-2.1
Shortness of breath walking on level ground	0.8	0.9	2.4	0.0	0.3	1.4	0.2	-0.9	1.2	-1.5
Mouth/teeth dental problems: Loose teeth	0.8	0.9	3.1	0.1	0.4	1.5	0.7	0.4	0.4	-1.8
Pain experienced in last month	0.8	1.3	5.2	1.1	0.3	2.3	-1.2	0.3	0.9	0.8
Breast Cancer	0.7	1.7	3.6	0.6	1.7	1.4	1.9	1.6	0.7	-0.2
Age at First Birth	0.7	1.0	2.5	0.4	0.6	1.3	0.5	1.5	-1.6	0.4
Hand grip strength (left)	0.7	1.8	3.7	-1.4	-1.9	-1.6	-0.2	-0.1	-1.9	-0.9
Hearing difficulty/problems: Yes	0.7	1.1	3.7	-0.8	1.4	-1.0	1.9	0.7	0.1	0.2
Pack years adult smoking proportion	0.7	1.0	1.8	-0.2	-1.1	-0.1	-1.1	-1.4	-1.1	-1.1
Fed-up feelings	0.7	1.4	4.4	-0.1	1.3	0.9	2.1	1.4	-0.8	0.3
Heart attack	0.7	0.9	3.5	0.2	0.3	-0.1	-0.4	-1.5	1.9	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	5.7	-1.5	-2.4	-1.6	-0.5	-0.2	-1.5	-1.8
Commuting to job workplace: Car/motor vehicle	0.7	0.9	4.6	-0.5	0.1	0.9	0.3	-0.0	0.3	-2.1
Long-standing illness, disability or infirmity	0.7	1.1	2.7	-0.5	-0.7	1.2	-0.9	-1.4	-0.3	-1.6
Average weekly champagne plus white wine intake	0.7	0.9	1.7	-0.7	-1.2	-0.1	-0.8	-1.2	1.3	-0.7
Alcohol drinker status: Never	0.7	0.8	4.5	-0.4	-0.6	0.2	-0.9	-0.3	-2.1	-0.0
Depression (Nagel 2018)	0.6	0.9	2.4	-1.1	-0.0	-0.4	0.1	-1.6	-0.2	-1.5
HbA1C	0.6	0.7	2.7	0.4	-1.3	0.1	-0.5	-0.2	-1.6	-0.3
Lupus	0.6	0.9	2.1	0.7	-0.9	1.4	-0.4	-0.9	0.8	-1.1
Neuroticism (2016)	0.6	0.9	2.6	-1.6	-0.4	-1.2	-0.3	-1.3	0.3	-0.6
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.6	-0.2	-0.1	-0.9	-0.6	0.1	-1.6	0.7
Medication: Co-codamol	0.6	0.7	1.6	-0.1	-1.0	1.3	-1.2	-0.3	-0.2	-0.6
Medication: Metformin	0.6	0.9	2.9	0.8	0.4	1.3	-0.1	-0.7	1.7	-0.4
Hand grip strength (right)	0.6	1.5	3.7	-1.5	-1.9	-1.6	-0.4	-0.4	-0.9	-0.9
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.6	0.1	1.1	1.6	0.7	0.6	-0.4	-0.6
Nervous feelings	0.6	1.1	4.2	0.1	2.0	-0.2	1.3	1.1	-0.4	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.9	0.2	1.0	-0.9	1.4	0.9	0.3	1.1
Fluid intelligence score	0.6	1.1	4.7	1.0	-1.0	0.0	-0.7	-0.0	2.2	0.8
Medication: Cholesterol lowering	0.6	1.0	2.7	-0.8	-0.1	1.6	-0.4	-0.8	-0.7	-1.6
Pulse wave reflection index	0.6	0.7	3.5	-0.5	-0.0	-1.0	-0.4	0.2	-1.9	0.6
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	3.3	0.6	0.4	1.7	0.1	0.7	1.8	0.2
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	3.1	-1.1	-0.9	0.1	-1.8	-1.0	-0.1	-1.4
Forced vital capacity (FVC), Best measure	0.6	2.0	4.6	-1.2	-2.1	-1.9	-0.1	0.0	-1.4	-1.6
Comparative body size at age 10	0.6	1.7	7.0	0.8	0.4	-1.0	-0.1	0.2	2.7	1.8
Medication: Ibuprofen	0.6	0.7	1.5	-0.7	-1.2	-0.3	-0.9	-0.9	-0.5	-0.8
Mean time to correctly identify matches	0.6	1.2	2.7	1.2	1.4	0.5	0.6	0.9	-1.7	0.8
Alcohol intake frequency.	0.6	1.4	3.1	0.4	1.8	-0.4	1.7	1.1	-0.0	1.4
Chest pain or discomfort	0.6	0.8	1.9	0.9	1.0	1.4	1.3	0.6	0.4	-0.4
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.5	0.8	0.2	-0.7	-0.6	-0.1	1.0	1.6
Loneliness, isolation	0.6	0.9	1.8	-0.7	-0.5	0.2	0.2	-1.3	-1.2	-1.4
Back pain experienced in last month	0.6	0.9	3.3	0.0	0.3	1.8	0.8	0.7	-0.4	-1.2
Guilty feelings	0.6	0.9	2.6	-1.2	-0.1	0.6	0.3	-1.1	0.8	-1.6
Wears glasses or contact lenses	0.6	0.7	1.9	0.4	0.9	1.4	0.9	0.2	1.1	-0.5
Medication: Bendroflumethiazide	0.6	0.9	5.2	0.6	0.8	2.3	-0.2	-0.1	-0.1	-0.4
Irritability	0.6	0.9	2.3	-1.5	-0.3	-1.0	-0.2	0.1	-1.2	-1.2
Risk taking	0.6	0.8	2.8	-0.7	-0.2	-1.7	0.3	-0.1	-1.5	0.0
Heart attack/myocardial infarction (self-reported)	0.6	0.8	3.4	0.4	0.3	-0.2	-0.4	-1.4	1.8	-0.3
Alzheimer’s Disease (in father)	0.5	0.6	2.6	0.6	0.1	-0.9	-0.4	-1.6	-0.1	-0.3
Reaction Time	0.5	1.0	2.2	0.7	1.5	-0.6	1.0	0.8	-0.9	1.1
Ovarian Cancer	0.5	0.6	2.1	0.3	0.3	0.2	0.8	1.1	-1.5	0.3
Lung FEV1/FVC ratio	0.5	2.5	8.8	-0.5	-2.3	-0.8	-1.6	-0.2	-3.0	-0.1
Number of treatments/medications taken	0.5	0.9	4.6	-0.3	-0.1	2.1	0.2	0.2	-0.7	-1.1
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.4	0.6	1.1	-0.3	0.8	-0.3	1.6	0.6
Supplements: Zinc	0.5	0.6	1.7	-0.4	-0.7	-0.3	0.3	-0.3	-1.3	-1.2
Number of live births	0.5	0.7	2.6	-0.6	0.0	1.6	-0.1	-0.2	1.1	-1.0
Qualifications: A levels/AS levels or equivalent	0.5	1.1	5.1	1.0	0.3	0.9	-0.0	0.8	2.3	0.5
Mouth/teeth dental problems: Dentures	0.5	0.8	2.8	-0.6	0.1	1.7	0.1	-0.3	-0.8	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.5	-0.7	1.1	-0.6	1.2	-0.0	-0.6	-1.2
Gout (self-reported)	0.5	0.7	2.2	-0.2	-0.4	1.4	0.2	0.4	1.5	-0.6
Birth weight	0.5	1.0	3.2	0.3	0.1	-1.8	0.5	1.1	0.5	1.4
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.6	-0.8	0.2	1.1	0.0	-0.4	-0.9	-1.3
Worry too long after embarrassment	0.5	0.8	1.7	-0.0	0.8	1.3	0.7	0.8	0.9	-1.1
Medication: Aspirin	0.5	0.7	2.3	0.4	0.2	0.7	-0.2	0.5	1.5	1.2
Osteoarthritis (self-reported)	0.5	0.7	2.1	-0.2	-1.2	-0.1	-1.4	-0.3	-0.5	-0.9
Number of self-reported non-cancer illnesses	0.5	0.9	2.7	-0.2	1.1	1.6	0.8	0.3	1.4	-0.5
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.9	-0.2	0.6	0.8	0.7	1.4	-0.9	0.4
Commuting to job workplace: Public transport	0.5	0.6	1.5	0.6	-0.4	1.2	-0.6	-0.4	1.1	0.6
Age started oral contraceptive pill	0.5	0.7	2.0	1.0	0.4	0.4	-0.1	1.0	-0.6	1.4
Diastolic blood pressure, automated reading	0.5	1.4	3.3	-0.1	1.5	0.4	1.7	1.8	-1.2	0.5
Heart disease (siblings)	0.5	0.6	1.4	-0.6	0.5	-1.2	1.2	0.5	0.8	0.1
Alcohol drinker status: Previous	0.5	0.6	1.4	-1.0	0.4	0.9	0.2	-0.8	0.4	-1.2
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.4	0.8	-1.4	-0.4	-1.4	-0.6	1.6	0.5
Fasting Glucose	0.4	0.5	1.1	-1.0	0.8	1.0	0.5	-0.0	-0.3	-0.6
Height	0.4	7.0	14.9	3.2	2.1	1.5	1.6	3.8	-0.1	3.9
Waist Hip Ratio (WHR)	0.4	1.8	4.3	-1.8	-0.2	0.9	0.3	-0.1	-2.1	-2.0
Lung FVC	0.4	1.9	7.9	-1.2	-1.2	-2.8	1.1	0.5	0.4	-1.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.2	-0.3	-0.3	-1.1	-1.1	-0.9	0.2	0.3
Ever had hysterectomy (womb removed)	0.4	0.4	1.5	-0.3	-0.7	-0.4	-1.2	-0.3	-0.4	-0.6
Angina	0.4	0.5	1.1	0.1	-0.2	1.0	-0.8	-0.8	0.7	-0.6
Townsend deprivation index at recruitment	0.4	0.6	1.9	-0.1	0.7	1.4	0.1	-0.5	1.1	-0.2
Age when periods started (menarche)	0.4	0.9	3.7	0.5	-0.6	-0.4	-1.9	-0.9	-0.6	0.7
Number of incorrect matches in round	0.4	0.6	2.0	0.3	1.4	0.5	1.1	0.4	0.8	0.2
Alcohol usually taken with meals	0.4	0.7	2.7	1.0	-0.4	-1.6	-0.2	0.3	0.5	0.9
Financial difficulties in last 2 years	0.4	0.5	1.2	0.8	1.1	0.6	0.7	0.9	0.0	-0.1
Medication: Simvastatin	0.4	0.5	1.0	-0.8	-0.5	0.9	-0.5	-0.8	0.1	-1.0
Pulse rate	0.4	0.7	2.7	-0.4	1.0	0.5	1.6	0.7	0.3	-0.1
Depression (self-reported)	0.4	0.5	1.6	0.3	0.2	1.2	0.1	-0.1	-1.3	-0.4
Standing height	0.4	3.6	7.8	2.7	1.0	1.5	0.4	2.5	0.3	2.8
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.5	-0.3	-1.0	-0.3	-0.1	-0.9	0.0	-1.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	2.8	-0.0	-0.2	-1.7	-0.0	-0.0	0.7	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	2.0	0.3	1.4	-0.0	1.0	0.6	-0.1	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.0	0.6	0.5	0.4	0.3	1.0	1.0	0.8
Pulse wave peak to peak time	0.4	0.4	1.2	-0.2	-0.7	0.4	-0.6	-0.6	1.1	-0.7
Medication for pain relief, constipation, heartburn	0.4	0.6	1.0	-0.5	-0.8	-0.1	-1.0	-0.8	-0.8	-1.0
Suffer from ‘nerves’	0.4	0.7	1.5	-1.2	-0.3	-1.1	-0.7	-0.9	-0.1	-0.7
Mood swings	0.4	0.7	2.2	-1.3	0.9	-0.2	1.5	0.1	-0.1	-0.6
Medication for cholesterol	0.4	0.7	2.8	-0.1	-0.5	-1.7	0.6	0.9	-0.4	0.6
Medication: Aspirin	0.4	0.5	1.8	0.3	0.1	1.1	0.0	0.3	1.3	0.7
Leg predicted mass (right)	0.4	1.9	5.5	1.2	1.5	-0.4	1.3	1.4	0.7	2.4
Hearing aid user	0.4	0.4	0.9	-0.4	-1.0	0.3	-0.4	-0.5	-1.0	-0.6
Illnesses of father: High blood pressure	0.4	0.5	1.3	-1.0	-0.1	0.3	0.3	-0.8	-0.5	-1.1
Leg fat percentage (left)	0.4	1.3	6.0	-2.4	-0.3	-0.3	-0.4	-1.3	-0.4	-1.0
Depressed Affect (Nagel 2018)	0.3	0.6	1.4	-1.2	0.4	-0.1	1.1	-0.5	-0.5	-0.9
Blood Platelet Count	0.3	3.3	13.1	-2.7	-0.9	-3.6	0.4	-0.5	-1.3	-0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.5	2.5	0.4	0.0	-0.1	-0.3	-0.7	1.6	0.1
Medication for hormone replacement therapy	0.3	0.3	0.6	0.8	0.8	0.8	-0.3	-0.0	-0.7	0.3
Leg fat-free mass (left)	0.3	1.8	4.7	1.2	1.5	-0.5	1.3	1.3	0.7	2.2
Current tobacco smoking	0.3	0.5	1.5	0.6	-0.6	0.4	-1.2	-0.9	-0.5	-0.1
Average weekly fortified wine intake	0.3	0.3	1.5	0.1	-0.4	-1.2	-0.3	-0.6	0.5	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.2	-0.9	-0.1	-0.2	0.5	-0.6	0.4	-1.1
Relative age voice broke	0.3	0.4	1.4	0.2	0.4	-0.5	1.2	0.1	0.9	0.2
High blood pressure	0.3	0.7	3.0	-1.0	-0.3	1.7	-0.1	-0.2	0.0	-1.0
Leg predicted mass (left)	0.3	1.7	4.6	1.1	1.4	-0.5	1.2	1.3	0.7	2.1
Hearing difficulty/problems with background noise	0.3	0.5	1.7	0.1	1.3	0.1	1.0	0.4	0.5	0.5
Neuroticism score	0.3	0.7	2.0	-0.5	1.2	0.6	1.4	0.6	0.2	-0.8
Alcohol intake versus 10 years previously	0.3	0.4	1.5	-0.1	0.4	0.6	0.8	1.2	0.0	0.6
Worrier / anxious feelings	0.3	0.6	1.9	-0.7	-1.0	-0.3	-1.4	-0.5	0.1	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.9	0.8	0.7	0.5	0.3	-0.3	1.4	0.5
Falls in the last year	0.3	0.5	1.3	-0.5	-0.7	-0.0	-0.7	-1.1	0.1	-0.9
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.5	-0.7	-1.6	-1.4	0.0	0.3	-0.5	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	2.2	-0.1	0.4	0.2	0.3	0.1	1.5	0.4
Medication: Lansoprazole	0.3	0.3	0.7	-0.1	-0.7	-0.6	-0.2	0.8	-0.8	0.0
Pulse wave Arterial Stiffness index	0.3	0.4	1.6	0.2	0.5	-0.2	0.3	0.5	-1.3	0.7
Exposure to tobacco smoke at home	0.3	0.4	1.1	0.4	0.9	0.1	0.2	-0.6	-1.1	-0.0
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.8	-0.8	0.5	-0.9	0.9	-0.3	-0.3	-0.3
Loud music exposure frequency	0.3	0.3	0.8	0.3	-0.1	0.3	-0.9	-0.7	0.8	0.4
Headache pain in last month	0.3	0.6	1.3	0.5	0.7	-0.7	1.1	0.4	1.1	0.4
Glaucoma (self-reported)	0.3	0.3	1.1	0.0	-0.6	-0.4	-0.7	-0.0	1.0	0.5
Leg fat percentage (right)	0.3	1.1	4.7	-2.2	-0.1	-0.4	-0.2	-1.3	-0.2	-1.0
Neck or shoulder pain in last month	0.3	0.4	1.0	-0.4	-0.2	-0.4	1.0	-0.0	-0.6	-0.9
Angina (self-reported)	0.3	0.4	0.7	-0.2	-0.4	0.7	-0.9	-0.8	0.3	-0.6
Medication: Omeprazole	0.3	0.4	1.6	0.7	-0.3	-1.3	-0.1	0.1	0.1	0.7
Number of full sisters	0.3	0.3	1.3	0.4	-0.3	-0.0	-0.8	-1.1	-0.1	-0.2
Knee pain experienced in last month	0.3	0.5	2.6	-0.9	-0.3	0.5	0.2	-0.2	0.2	-1.6
Smoking status: Previous	0.3	0.5	2.1	0.0	0.6	1.4	0.1	-0.3	0.5	-0.7
Leg fat-free mass (right)	0.3	1.8	5.1	1.2	1.4	-0.4	1.3	1.4	0.6	2.3
Ever had bowel cancer screening	0.3	0.4	1.1	0.9	0.1	1.0	-0.1	0.3	-0.9	0.1
Diabetes diagnosed by doctor	0.3	0.5	1.0	0.7	0.2	1.0	-0.6	-0.6	1.0	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.8	-0.8	0.4	-0.3	0.9	-0.2	-0.3	-0.9
Breast cancer (self-reported)	0.3	0.3	1.0	-0.9	-1.0	-0.5	-0.1	0.2	-0.3	-0.1
Illnesses of father: None of the above (group 1)	0.3	0.3	1.4	0.5	-0.0	0.1	0.5	1.2	-0.5	0.3
Eye problems/disorders: Glaucoma	0.3	0.4	0.7	0.5	-0.4	-0.5	-0.8	0.2	0.8	0.8
Medication: Blood pressure	0.3	0.5	1.3	-0.9	0.0	0.5	-0.3	-1.0	-0.1	-1.1
Medication: Atorvastatin	0.3	0.4	0.8	-0.1	-0.7	-0.7	-0.7	-0.5	-0.9	-0.2
Cholesterol lowering medication	0.3	0.5	1.3	-0.5	-0.5	-0.7	-0.8	-1.1	-0.2	-0.6
Neuroticism (Nagel 2018)	0.2	0.4	1.2	-1.1	0.4	-0.5	0.5	-0.6	-0.2	-1.0
Worry (Nagel 2018)	0.2	0.4	1.2	-0.8	-0.3	-1.1	-0.7	-0.6	-0.5	-0.4
BMI	0.2	1.4	4.8	-2.2	-0.7	-0.4	-0.5	-1.4	-0.7	-1.2
Cardiovascular Disease	0.2	0.8	2.0	-0.8	-0.5	1.4	-0.6	-0.6	-0.3	-1.4
Neuroticism	0.2	0.4	1.5	-0.9	0.3	-0.3	0.4	-0.4	-0.5	-1.2
Sensitivity / hurt feelings	0.2	0.3	1.4	-0.1	1.2	0.4	0.8	0.3	0.2	0.0
Systolic blood pressure, automated reading	0.2	0.7	1.6	0.5	1.0	0.5	1.3	1.2	-0.5	-0.0
Vitamin and mineral supplements	0.2	0.3	0.8	0.9	-0.2	0.9	-0.4	0.1	-0.2	-0.2
Impedance of leg (right)	0.2	0.8	1.7	-0.8	-1.0	0.6	-1.2	-0.7	-0.1	-1.3
Serious illness, injury or assault to yourself	0.2	0.2	1.0	-0.4	-0.3	-0.3	-0.2	-0.2	-1.0	0.1
Medication: Atenolol	0.2	0.3	1.0	0.2	-0.2	0.1	-0.8	-0.0	0.4	1.0
Sitting height	0.2	1.5	3.0	1.2	-0.4	-1.7	0.2	1.7	-0.5	1.7
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	-0.5	-0.4	-0.1	-0.7	-0.7	-0.4	-0.1
Body mass index (BMI)	0.2	1.0	3.8	-2.0	-0.1	-0.8	0.0	-1.2	-0.5	-0.8
Impedance of leg (left)	0.2	1.1	1.8	-1.1	-1.2	0.9	-1.3	-0.8	-0.1	-1.4
Waist circumference	0.2	0.9	2.9	-1.7	-0.1	0.3	-0.3	-1.3	-0.6	-0.9
Past tobacco smoking	0.2	0.4	1.1	0.3	-0.6	-1.0	0.1	0.5	-0.8	0.7
Forced vital capacity (FVC)	0.2	0.7	2.4	-0.4	-1.3	-1.6	0.4	0.5	0.3	-0.7
Qualifications: None of the above	0.2	0.3	1.2	0.2	0.4	-0.8	-0.1	0.3	-0.5	1.1
Illnesses of siblings	0.2	0.3	0.7	-0.3	0.7	0.2	0.8	-0.4	-0.4	-0.4
Asthma	0.2	0.4	2.0	0.1	0.7	1.4	-0.0	0.2	-0.3	-0.4
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.3	1.1	0.6	0.4	0.2	0.2	-0.1	0.6
Number of children fathered	0.2	0.2	0.5	0.7	0.5	0.4	0.6	0.5	-0.4	0.1
Migraine (self-reported)	0.2	0.2	0.8	0.9	0.2	0.4	0.1	0.4	-0.1	0.7
Heart disease (mother)	0.2	0.3	0.6	-0.7	0.4	-0.1	0.7	-0.1	0.8	-0.5
Overall health rating	0.2	0.5	2.7	0.1	0.8	1.6	0.2	0.1	0.3	0.3
Age at last live birth	0.2	0.3	1.7	0.5	0.0	1.3	0.2	-0.2	0.2	-0.4
Illnesses of siblings: Diabetes	0.2	0.2	0.6	-0.7	-0.0	0.0	0.1	0.8	0.7	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.7	0.7	0.2	-0.7	-0.5	-0.1	0.9	0.7
Average weekly red wine intake	0.2	0.3	1.7	-0.4	-0.3	0.2	-0.1	-0.4	-0.2	-1.3
Qualifications: nursing, teaching	0.2	0.3	1.1	-0.3	-1.0	-0.2	-0.5	-0.7	0.0	-0.7
Asthma (self-reported)	0.2	0.3	1.6	0.1	0.7	1.3	-0.0	0.2	-0.2	-0.3
Smoking status: Current	0.2	0.3	1.2	0.4	-0.4	0.1	-1.1	-0.8	-0.5	0.0
Miserableness	0.2	0.4	0.7	-0.7	0.5	0.2	0.8	0.2	0.8	-0.6
Ever taken oral contraceptive pill	0.2	0.2	0.5	-0.2	-0.2	-0.6	-0.6	-0.7	0.0	-0.0
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.6	-0.5	-0.0	-0.4	0.7	0.2	-0.7	-0.8
Ever smoked	0.2	0.4	1.0	-0.7	-0.5	0.2	-0.9	-1.0	0.1	-0.7
Fractured/broken bones in last 5 years	0.2	0.2	0.6	0.5	0.3	-0.1	0.7	-0.2	-0.0	0.8
Commuting to job workplace: Cycle	0.2	0.3	0.8	0.2	-0.8	-0.9	-0.2	-0.1	0.5	0.2
Vascular/heart problems diagnosed by doctor	0.2	0.6	3.2	0.5	0.1	-1.8	0.0	0.0	0.1	0.7
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.7	0.8	0.2	-0.2	0.5	0.6	0.5	0.6
Impedance of whole body	0.2	1.0	2.9	0.7	0.7	1.7	0.3	0.7	1.6	0.5
Prostate Cancer	0.1	0.2	0.5	-0.0	-0.1	0.6	-0.7	-0.0	-0.4	-0.6
Rheumatoid Arthritis	0.1	0.1	0.6	0.0	0.8	0.0	0.0	0.0	0.0	0.0
Blood Red Count	0.1	0.6	2.0	-1.4	-0.6	0.6	-0.9	-0.7	-0.1	-0.1
Systolic Blood Pressure	0.1	0.7	2.0	0.4	0.1	1.4	0.0	0.3	-1.0	-1.3
Smoking Status	0.1	0.3	0.8	0.0	0.4	0.9	-0.6	-0.4	-0.8	0.4
Hair Pigment	0.1	2.1	12.2	1.0	-0.4	3.5	-0.9	-0.3	-0.9	0.0
Tanning	0.1	1.3	4.2	0.2	0.9	1.7	-0.7	-0.6	2.0	-0.6
Relative age of first facial hair	0.1	0.2	0.9	-0.2	0.2	0.3	0.9	0.2	-0.1	-0.3
Trunk fat percentage	0.1	0.5	1.2	-1.1	0.8	0.4	0.5	-0.4	1.0	0.3
Medication: Levothyroxine sodium	0.1	0.2	0.5	-0.2	-0.0	0.4	-0.7	0.2	0.4	-0.6
Trunk fat mass	0.1	0.3	0.7	-0.8	0.7	0.3	0.4	-0.2	0.7	0.7
Diabetes (self-reported)	0.1	0.1	0.2	0.4	0.4	0.4	-0.1	-0.2	0.3	0.3
Arm fat percentage (right)	0.1	0.5	1.5	-1.2	0.7	0.7	0.4	-0.6	0.3	-0.1
Trunk fat-free mass	0.1	0.5	1.6	0.6	-0.3	-0.5	-0.5	0.5	-1.3	0.9
Hip circumference	0.1	0.3	1.6	-0.7	0.1	0.0	-0.2	-1.3	-0.2	-0.0
Happiness	0.1	0.2	0.6	-0.8	-0.3	0.2	0.1	0.2	0.2	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.2	-0.4	-0.4	0.4	0.1	-0.1	-0.4
Arm fat mass (right)	0.1	0.3	1.2	-1.1	0.5	0.4	0.2	-0.4	0.1	0.1
Trunk predicted mass	0.1	0.5	1.4	0.7	-0.3	-0.5	-0.5	0.6	-1.2	1.0
Blood clot in the leg (DVT)	0.1	0.1	0.4	-0.2	-0.2	0.0	0.6	-0.0	-0.4	-0.5
Medication: Paracetamol	0.1	0.2	0.5	-0.2	0.5	-0.6	0.7	0.1	0.1	0.2
Body fat percentage	0.1	0.5	2.4	-1.5	0.6	0.3	0.2	-0.7	0.5	-0.1
Arm fat-free mass (right)	0.1	0.4	1.1	-0.2	-0.0	-1.1	0.0	0.4	-0.7	0.8
Age at first live birth	0.1	0.2	0.4	0.4	-0.4	-0.1	-0.5	0.1	-0.6	0.4
Medication: Blood pressure	0.1	0.2	1.2	0.1	0.4	1.1	-0.2	0.3	0.4	0.3
Whole body fat mass	0.1	0.3	1.3	-1.2	0.5	0.3	0.1	-0.4	0.2	0.2
Leg fat mass (right)	0.1	0.4	2.2	-1.5	0.4	-0.3	0.3	-0.5	0.2	-0.2
Arm predicted mass (right)	0.1	0.4	1.2	-0.1	-0.0	-1.0	-0.1	0.3	-1.1	0.7
Pulse rate, automated reading	0.1	0.2	1.1	-0.7	0.1	-0.4	0.1	0.2	-1.0	0.0
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.5	-0.1	0.3	0.4	0.2	-0.2	0.7	-0.4
Hypertension (Self-reported)	0.1	0.4	2.1	-0.6	-0.0	1.5	-0.2	-0.1	0.3	-0.5
Whole body fat-free mass	0.1	0.6	2.1	0.8	0.4	-0.5	0.2	0.9	-0.7	1.4
Arm fat percentage (left)	0.1	0.6	2.1	-1.4	0.9	0.4	0.5	-0.7	0.4	0.0
Commuting to job workplace: Walk	0.1	0.1	0.6	0.2	-0.0	-0.1	0.1	0.3	-0.1	0.8
Whole body water mass	0.1	0.6	1.9	0.7	0.3	-0.6	0.2	0.9	-0.7	1.4
Arm fat mass (left)	0.1	0.4	2.0	-1.4	0.4	0.3	0.2	-0.6	0.0	-0.0
Medication: Paracetamol	0.1	0.1	0.3	-0.0	0.4	-0.5	0.5	-0.1	0.3	0.5
Basal metabolic rate	0.1	0.4	1.5	0.4	0.4	-0.4	0.2	0.6	-0.4	1.2
Arm fat-free mass (left)	0.1	0.3	1.2	-0.3	-0.4	-0.4	-0.2	0.3	-1.1	0.2
Myopia	0.1	0.1	0.3	-0.0	-0.1	0.1	-0.2	-0.3	0.5	0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.6	-0.0	-0.2	-0.2	0.8	0.1	0.1	-0.0
Leg fat mass (left)	0.1	0.5	2.9	-1.7	0.2	-0.2	0.0	-0.6	-0.1	-0.3
Arm predicted mass (left)	0.1	0.3	1.3	-0.2	-0.3	-0.3	-0.1	0.6	-1.2	0.2
Bipolar Disorder (2018)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder or Schizophrenia	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2018)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Weight	0.0	0.2	0.4	-0.5	0.5	-0.2	0.4	0.1	-0.2	0.6

Hub : Genes

GRIN3B

Models

Trait associations