TWAS hub - SLC2A1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0748	0.0323	0.0009	0.046	0.011	0.026	0.022	0.037	1.7e-07	0.00630	7.0e-05	0.00025	2.3e-06
2	TCGA	Breast Invasive Carcinoma	0.0338	0.0172	0.0013	0.016	0.019	0.019	NA	0.017	2.1e-04	0.00008	5.7e-05	NA	1.3e-04
3	TCGA	Thyroid Carcinoma	0.0690	0.0370	0.0085	-0.002	0.011	0.005	NA	-0.002	5.7e-01	0.02600	8.6e-02	NA	5.1e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Age at last live birth	4.8	7.0	11.9	-3.0	0.2	-3.5
Medication: Lisinopril	4.5	5.8	12.7	3.6	2.1	-0.1
Fractured/broken bones in last 5 years	3.8	4.9	14.1	-0.4	-3.8	-0.7
Fasting Glucose	3.5	4.2	8.2	-1.5	1.5	-2.9
Blood White Count	3.2	24.0	61.6	-7.8	-2.8	-1.7
Hearing difficulty/problems with background noise	2.9	4.6	6.9	0.4	-2.6	2.6
Average weekly fortified wine intake	2.8	3.3	9.0	0.6	0.7	-3.0
Wears glasses or contact lenses	2.8	3.2	6.7	0.2	2.6	-1.7
Pulse wave reflection index	2.7	3.3	9.9	0.2	3.1	-0.3
Birth weight	2.7	6.0	11.6	1.1	-2.2	3.4
LDL Cholesterol	2.6	4.1	8.0	2.8	1.8	1.1
Loud music exposure frequency	2.6	2.8	7.5	-0.1	-1.0	2.7
Medication: Amlodipine	2.6	3.7	5.9	2.2	2.4	0.6
Vitamin and mineral supplements	2.5	3.4	6.0	1.9	2.5	0.8
Worry (Nagel 2018)	2.4	5.0	5.8	-2.4	-2.0	-2.3
Bilateral oophorectomy (both ovaries removed)	2.3	2.7	6.2	0.0	2.5	1.3
Ever unenthusiastic/disinterested for a whole week	2.3	2.8	4.3	1.9	0.8	2.1
Hypertension (Self-reported)	2.3	6.3	10.8	3.3	2.8	0.1
Vascular/heart problems diagnosed by doctor	2.3	6.3	12.0	-3.5	-2.6	-0.3
Depression (Nagel 2018)	2.2	3.3	6.2	-2.5	-1.6	-1.1
Multivitamins +/- minerals	2.2	2.8	5.1	-1.7	-2.3	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.5	4.3	-2.1	0.3	-1.8
Pulse wave peak to peak time	2.2	2.5	7.2	0.4	-2.7	0.4
Alcohol drinker status: Previous	2.2	2.5	4.1	1.2	-2.0	1.4
Medication for cholesterol, blood pressure or diabetes	2.1	3.5	6.6	-2.6	-1.4	-1.3
Smoking Status	2.0	4.9	7.8	0.4	-2.6	2.8
High blood pressure	2.0	5.7	11.1	3.3	2.4	0.3
Medication: Simvastatin	2.0	2.9	4.6	2.1	0.2	2.0
Relative age of first facial hair	1.9	3.8	4.7	1.5	-2.2	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	5.9	-2.4	0.4	-1.3
Worry too long after embarrassment	1.9	3.2	7.6	-1.4	-0.1	-2.8
Age at first live birth	1.9	3.4	5.4	-2.1	0.6	-2.3
Knee pain experienced in last month	1.9	3.0	5.9	1.8	-0.2	2.4
Alzheimer’s Disease (in mother)	1.8	2.1	3.3	-0.2	1.8	-1.8
Allergy or Eczema	1.8	4.8	7.8	-2.8	-2.3	-1.1
Ever used hormone-replacement therapy (HRT)	1.8	2.3	4.2	-2.0	1.2	-1.0
Diabetes (mother)	1.8	2.3	6.3	-2.5	-0.2	-0.7
Hayfever, allergic rhinitis or eczema	1.8	4.0	8.2	-2.9	-1.5	-1.2
Financial difficulties in last 2 years	1.8	2.4	5.4	-2.3	-1.2	0.5
Noisy workplace	1.8	2.2	3.9	1.5	2.0	-0.7
Medication: Atorvastatin	1.8	2.2	3.7	1.3	1.9	-1.1
Cholesterol lowering medication	1.8	2.7	4.9	1.7	2.2	-0.2
High blood pressure (mother)	1.7	2.4	5.7	1.0	-0.7	2.4
Pulse wave Arterial Stiffness index	1.7	2.0	5.6	-0.4	2.4	-0.4
Medication: Blood pressure	1.7	2.9	4.9	1.9	2.2	0.6
Pulse rate, automated reading	1.7	5.4	8.4	0.6	2.7	-2.9
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	4.2	1.5	-0.1	2.0
Breast Cancer	1.6	3.8	6.6	0.8	-2.6	2.1
Frequency of depressed mood in last 2 weeks	1.6	2.3	4.0	-2.0	-1.3	-1.1
Blood clot in the leg (DVT)	1.6	2.1	3.7	1.6	0.0	1.9
Medication: Ventolin 100micrograms inhaler	1.6	2.1	3.6	-1.9	0.6	-1.5
Health satisfaction	1.6	2.1	3.1	1.8	1.2	1.3
Supplements: Vitamin C	1.6	1.9	5.0	-0.8	-2.2	0.0
Ever smoked	1.6	2.9	4.5	-0.6	-1.9	2.1
Supplements: Calcium	1.6	1.7	4.4	-0.9	-0.3	-2.1
Pulse rate	1.5	2.5	3.2	1.7	1.8	-1.2
Medication: Gliclazide	1.5	1.7	4.1	0.9	2.0	-0.4
Eye problems/disorders: Glaucoma	1.5	1.8	5.1	-2.3	-0.3	0.4
Pain type(s) experienced in last month: Hip pain	1.5	1.9	4.1	-0.8	-2.0	1.1
Alzheimer’s Disease (including proxy)	1.4	2.0	3.3	-0.5	1.6	-1.8
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	1.9	-1.2	-1.2	-1.4
Medication: Atenolol	1.4	1.8	3.9	-0.5	2.0	-1.1
Impedance of arm (right)	1.4	6.4	11.1	-3.3	-1.5	-2.4
Depression (self-reported)	1.4	1.7	3.0	-1.3	-0.6	-1.7
Number of children fathered	1.4	1.6	2.7	0.3	1.6	-1.4
Leg pain on walking	1.4	1.8	2.7	1.6	1.1	1.2
Neuroticism (Nagel 2018)	1.3	3.1	6.1	-2.5	-0.8	-1.6
Age at First Birth	1.3	1.8	2.7	-1.6	-1.6	-0.4
Primary Biliary Cirrhosis	1.3	1.9	5.0	0.8	-2.2	0.1
Blood Red Count	1.3	12.9	23.1	4.8	3.2	2.2
Past tobacco smoking	1.3	2.4	3.5	0.6	1.8	-1.9
Alcohol usually taken with meals	1.3	2.1	4.5	1.2	2.1	-0.5
Length of working week for main job	1.3	1.4	2.3	-1.5	-0.2	-1.4
Mouth/teeth dental problems: Loose teeth	1.3	1.6	3.1	-1.0	-1.8	-0.7
Medication: Blood pressure	1.3	2.5	4.5	1.7	2.1	0.1
Cardiovascular Disease	1.2	3.9	8.0	2.8	1.9	0.2
Medication for hormone replacement therapy	1.2	1.4	1.6	-1.0	1.3	-1.3
Supplements: Glucosamine	1.2	1.6	3.2	1.8	-0.1	1.3
Gout (self-reported)	1.2	1.6	2.1	1.5	1.5	0.8
Suffer from ‘nerves’	1.2	1.9	4.6	-0.9	0.6	-2.1
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	2.8	1.7	-1.1	-0.4
Medication: Bendroflumethiazide	1.2	1.8	2.4	1.5	1.6	0.7
Neuroticism	1.1	2.6	3.5	-1.9	-0.9	-1.8
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.8	4.4	-2.1	-0.9	-0.5
Medication: Ramipril	1.1	1.4	2.6	0.5	1.6	-1.1
Neuroticism score	1.1	2.3	3.8	-1.7	-0.5	-2.0
Mouth/teeth dental problems: Dentures	1.1	1.8	2.3	1.2	1.3	-1.5
Medication: Aspirin	1.1	1.5	3.4	0.4	-1.8	0.9
Commuting to job workplace: Walk	1.1	1.2	3.5	0.4	-1.9	-0.0
Smoking status: Current	1.1	1.7	2.8	-0.3	-1.7	1.5
Ever depressed for a whole week	1.1	1.4	2.5	1.1	-0.7	1.6
Medication: Co-codamol	1.0	1.1	1.5	0.9	-1.2	1.0
Current tobacco smoking	1.0	1.7	2.9	-0.1	-1.5	1.7
Medication: Cholesterol lowering	1.0	1.6	3.8	2.0	-0.2	1.0
Medication: Omeprazole	1.0	1.2	3.1	0.5	-1.8	0.5
Medication: Seretide 50 evohaler	1.0	1.2	2.4	-1.6	-1.0	-0.4
Arm predicted mass (right)	1.0	5.2	9.0	3.0	1.2	2.2
Alcohol intake frequency.	1.0	2.4	6.2	2.5	0.9	0.0
Medication for cholesterol	1.0	1.6	3.5	-0.3	-1.9	1.1
Alcohol drinker status: Never	1.0	1.2	2.6	0.9	1.6	-0.4
Pack years of smoking	1.0	1.4	3.3	1.8	0.1	1.0
Allergy	0.9	2.1	3.9	2.0	1.5	0.4
Trunk fat-free mass	0.9	5.0	6.5	2.5	1.6	2.4
Worrier / anxious feelings	0.9	1.8	2.6	-1.4	-0.8	-1.6
Impedance of arm (left)	0.9	4.0	5.3	-2.3	-1.2	-2.3
Glaucoma (self-reported)	0.9	1.1	3.1	-1.8	-0.3	-0.1
Arm fat-free mass (right)	0.9	4.7	7.4	2.7	1.3	2.2
Exposure to tobacco smoke outside home	0.9	1.2	1.9	-1.1	-1.4	-0.8
Emphysema/chronic bronchitis	0.9	1.0	1.8	-0.6	-1.4	-0.9
Medication: Ibuprofen	0.9	1.0	2.2	-0.9	1.5	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	1.6	-1.2	-1.3	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.4	-1.5	-0.8	0.1
Major Depression (MDD)	0.8	1.0	1.6	-0.2	-1.3	1.1
Crohns Disease (2012)	0.8	1.3	1.9	1.4	-1.1	0.8
Angina	0.8	1.0	2.0	-0.1	1.4	-1.0
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.6	-0.0	-0.4	1.6
Chronic bronchitis/emphysema (father)	0.8	0.9	1.6	1.1	1.3	0.0
Mouth/teeth dental problems	0.8	1.2	3.3	-0.5	-0.0	1.8
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.8	0.0	-1.7	0.5
Trunk predicted mass	0.8	4.5	5.8	2.4	1.6	2.3
Exposure to tobacco smoke at home	0.8	0.9	2.2	-0.0	-0.8	1.5
Ever highly irritable/argumentative for 2 days	0.8	1.0	1.8	1.4	0.6	0.9
Shortness of breath walking on level ground	0.8	1.0	2.8	1.7	0.1	0.4
Illnesses of father: Heart disease	0.8	1.1	2.0	-1.4	-1.0	0.5
Whole body fat-free mass	0.8	4.6	6.9	2.6	1.3	2.3
Back pain experienced in last month	0.8	1.2	3.4	-1.8	-0.5	0.2
Osteoporosis (self-reported)	0.8	0.9	1.5	-1.2	-1.1	0.0
Osteoarthritis (self-reported)	0.8	1.0	2.0	1.4	0.9	-0.4
Whole body water mass	0.8	4.3	6.2	2.5	1.3	2.2
High cholesterol (Self-reported)	0.8	1.5	3.9	2.0	0.5	0.6
Arm fat-free mass (left)	0.8	4.0	5.4	2.3	1.5	2.1
Commuting to job workplace: Cycle	0.8	0.9	1.1	-0.8	-1.0	-1.0
Impedance of whole body	0.8	4.0	6.0	-2.3	-0.9	-2.4
Depressed Affect (Nagel 2018)	0.7	1.5	3.9	-2.0	0.2	-0.7
Reaction Time	0.7	1.3	2.4	1.5	0.9	0.8
HDL Cholesterol	0.7	1.2	2.7	-1.6	-0.3	-0.9
Rheumatoid Arthritis	0.7	1.0	2.2	0.4	0.8	-1.5
Chronotype (morning person)	0.7	1.6	2.9	-0.4	1.7	-1.3
Townsend deprivation index at recruitment	0.7	1.0	2.5	0.1	-0.6	1.6
Age when periods started (menarche)	0.7	1.6	4.8	-0.2	-2.2	0.1
Nervous feelings	0.7	1.2	2.5	-1.6	-0.7	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	1.5	-1.2	1.0	0.3
Neck or shoulder pain in last month	0.7	1.0	1.5	0.2	-1.2	-1.2
Heart disease (mother)	0.7	0.9	1.3	-0.7	1.1	0.9
Smoking status: Previous	0.7	1.1	1.8	-0.3	-1.2	1.4
Medication: Aspirin	0.7	0.9	1.5	0.6	-1.2	0.8
Basal metabolic rate	0.7	4.0	5.5	2.3	1.3	2.1
Average weekly beer plus cider intake	0.7	1.0	2.2	-0.9	-1.5	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.1	-0.5	-1.5	-0.5
Arm predicted mass (left)	0.7	3.8	5.5	2.3	1.6	1.9
Schizophrenia (2018)	0.6	1.2	3.0	-1.7	0.1	-0.7
Neuroticism (2016)	0.6	0.8	1.7	-0.8	0.2	-1.3
Triglycerides	0.6	1.0	2.9	1.7	0.1	-0.4
Heel T-Score	0.6	4.6	9.6	3.1	1.9	-0.7
Respiratory disease	0.6	1.4	3.2	-1.8	-0.9	-0.5
Supplements: Zinc	0.6	0.6	1.8	1.3	0.4	0.1
Pack years adult smoking proportion	0.6	1.0	2.1	1.4	-0.3	0.8
Qualifications: CSEs or equivalent	0.6	0.8	1.2	0.7	0.8	1.1
Medication: Levothyroxine sodium	0.6	1.0	1.9	1.4	0.9	0.6
Weight	0.6	2.7	4.1	1.8	1.0	2.0
Father’s age at death	0.6	0.8	1.7	0.1	0.8	-1.3
Hair/balding pattern: Pattern 3	0.6	1.0	1.7	0.9	1.3	0.6
Medication: Lansoprazole	0.6	0.7	1.3	0.9	-0.0	-1.1
Illnesses of mother	0.6	0.8	1.2	-1.0	-0.2	-1.1
Angina (self-reported)	0.6	0.7	1.5	-0.2	1.2	-0.8
Comparative height size at age 10	0.6	3.4	5.6	2.4	2.1	0.5
Had major operations	0.6	0.7	1.7	1.3	-0.2	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.4	-1.2	0.1	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.6	1.6	0.4	-0.4	-1.3
Leg fat-free mass (right)	0.6	3.3	5.8	2.4	0.9	1.8
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.4	-0.8	0.5	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.9	-0.5	0.8	-1.4
Leg predicted mass (right)	0.6	3.3	5.9	2.4	0.9	1.8
Miserableness	0.6	1.1	1.5	-0.7	1.2	-1.1
Guilty feelings	0.6	1.0	1.8	-1.3	-0.7	-0.8
Financial situation satisfaction	0.6	0.8	2.2	-1.5	-0.2	-0.2
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.2	-1.1	-1.1	-0.1
Crohns Disease (2017)	0.5	1.1	1.3	0.9	-1.1	1.1
Ulcerative Colitis (UC)	0.5	0.9	1.2	1.1	1.0	0.5
Ovarian Cancer	0.5	0.7	1.4	0.8	-0.4	1.2
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.2	1.1	0.7	-0.3
Number of treatments/medications taken	0.5	0.9	2.0	0.4	1.4	0.8
Hearing difficulty/problems: Yes	0.5	0.8	1.4	-0.6	-0.8	1.2
Ever had hysterectomy (womb removed)	0.5	0.6	1.5	-0.6	1.2	0.0
Impedance of leg (right)	0.5	2.4	3.9	-2.0	-0.8	-1.7
Leg fat-free mass (left)	0.5	2.4	4.2	2.0	1.1	1.4
Relative age voice broke	0.5	0.8	2.0	0.4	-1.4	0.4
Body mass index (BMI)	0.5	2.1	4.5	0.9	0.9	2.1
Leg predicted mass (left)	0.5	2.5	4.2	2.1	1.1	1.4
Had menopause	0.5	0.6	1.4	-1.2	0.7	-0.1
Had other major operations	0.5	0.7	1.7	-1.3	0.5	0.1
Qualifications: None of the above	0.5	1.1	2.5	0.6	-0.7	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	0.8	-0.9	-0.8	0.5
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.8	-0.0	-1.3	0.2
Mood swings	0.5	1.0	1.9	-1.4	-0.9	0.5
Hearing aid user	0.5	0.6	0.9	-1.0	-0.5	0.8
Risk taking	0.5	0.7	1.7	-0.4	0.6	-1.3
Pain experienced in last month	0.5	0.8	1.2	-0.3	1.1	-1.0
Heart disease (siblings)	0.5	0.6	1.3	0.0	1.1	0.8
Ulcerative Colitis	0.4	0.5	1.5	1.2	0.1	-0.2
BMI	0.4	2.0	5.1	0.8	2.2	0.7
Hypothyroidism (self reported)	0.4	0.8	1.5	1.2	-0.5	0.8
Hand grip strength (left)	0.4	1.0	1.8	-1.0	-1.3	-0.4
Sensitivity / hurt feelings	0.4	0.7	1.7	0.4	-1.3	-0.5
Diabetes (father)	0.4	0.5	1.1	1.1	-0.6	-0.0
Maternal smoking around birth	0.4	0.6	1.5	-0.0	-0.6	1.2
Fed-up feelings	0.4	0.8	1.4	-1.2	0.6	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.0	1.0	1.0	-0.8
Time employed in main current job	0.4	0.5	1.4	0.2	-1.2	0.2
Falls in the last year	0.4	0.6	1.4	0.6	-1.2	-0.2
Happiness	0.4	0.4	0.8	0.5	0.5	0.9
Prospective memory result	0.4	0.5	1.1	-1.0	-0.3	0.5
Hair/balding pattern: Pattern 4	0.4	1.0	2.2	-0.9	-1.5	-0.3
Headache pain in last month	0.4	0.6	1.6	0.0	-1.3	-0.5
Number of full brothers	0.4	0.5	1.4	-0.1	-0.2	1.2
Eye problems/disorders: None of the above	0.4	0.5	1.3	0.3	0.2	1.1
Medication: Allopurinol	0.4	0.5	0.9	1.0	-0.0	0.8
Mean time to correctly identify matches	0.4	0.8	1.3	1.1	0.7	0.8
Overall health rating	0.4	0.8	2.4	-0.0	-0.1	1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.9	0.2	-1.4	-0.8
Average weekly red wine intake	0.4	0.5	1.1	0.5	1.0	0.5
Loneliness, isolation	0.4	0.5	0.9	-1.0	0.5	-0.6
Diabetes diagnosed by doctor	0.4	0.6	1.3	-0.2	1.1	-0.7
Friendships satisfaction	0.4	0.5	0.6	-0.6	-0.8	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.6	-1.3	-0.8	-0.6
Basal cell carcinoma (self-reported)	0.4	0.5	1.2	-0.6	1.1	0.2
Bipolar Disorder or Schizophrenia	0.3	0.7	1.9	-1.4	0.1	-0.4
Irritable Bowel Disease (IBD)	0.3	0.6	1.2	1.1	0.4	0.7
Mean Putamen Volume	0.3	0.4	0.7	-0.6	-0.8	0.4
HbA1C	0.3	0.3	0.8	0.9	-0.3	-0.1
Lung FEV1/FVC ratio	0.3	1.5	3.3	-1.1	0.4	-1.8
Average weekly spirits intake	0.3	0.3	0.6	0.5	-0.4	-0.8
Systolic blood pressure, automated reading	0.3	0.7	1.2	-1.0	-1.1	0.1
Severe depression (siblings)	0.3	0.4	0.6	-0.7	0.7	0.3
Taking other prescription medications	0.3	0.4	0.8	-0.9	-0.7	-0.2
Impedance of leg (left)	0.3	1.4	2.7	-1.6	-0.7	-0.9
Waist circumference	0.3	1.2	2.1	1.0	0.7	1.4
Heart attack	0.3	0.4	1.0	0.0	1.0	0.6
Pain all over the body in last month	0.3	0.3	0.4	0.6	-0.4	0.6
Fluid intelligence score	0.3	0.7	0.9	0.8	-1.0	-0.7
Illnesses of siblings	0.3	0.5	0.8	-0.5	-0.6	-0.9
Arm fat mass (right)	0.3	1.1	2.5	0.3	0.8	1.6
Peak expiratory flow (PEF)	0.3	0.7	1.1	-1.0	-0.8	-0.4
High blood pressure (siblings)	0.3	0.5	0.6	0.6	0.7	0.7
Migraine (self-reported)	0.3	0.3	0.8	-0.4	-0.9	-0.1
Leg fat mass (right)	0.3	1.3	2.4	0.6	1.1	1.6
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.9	0.2	0.9	0.1
Qualifications: nursing, teaching	0.3	0.4	0.9	0.9	0.5	-0.4
Breast cancer (self-reported)	0.3	0.3	0.5	-0.7	0.6	-0.4
Arm fat mass (left)	0.3	1.1	2.7	0.4	0.7	1.6
Ever taken oral contraceptive pill	0.3	0.3	0.7	0.2	-0.5	0.8
Mother’s age at death	0.3	0.4	1.1	1.0	-0.1	0.1
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.7	-0.8	-0.7	-0.1
Number of operations (self-reported)	0.3	0.4	1.3	-0.1	1.1	0.2
Age started oral contraceptive pill	0.3	0.4	0.8	0.9	0.6	0.3
Unable to work because of sickness or disability	0.3	0.3	0.9	0.2	0.9	-0.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.7	0.1	0.9	0.6
Leg fat mass (left)	0.3	1.4	2.7	0.5	1.0	1.7
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.0	1.0	-0.2	-0.3
Prostate Cancer	0.2	0.3	0.8	0.9	0.2	-0.1
Coronary Artery Disease (CAD)	0.2	0.2	0.6	0.8	0.2	-0.1
Lupus	0.2	0.3	1.0	0.0	-0.0	1.0
Height	0.2	4.4	12.8	3.6	0.0	-0.5
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.9	0.2	0.9	-0.3
Hand grip strength (right)	0.2	0.7	1.8	-0.2	-1.4	0.4
Serious illness, injury or assault to yourself	0.2	0.3	0.7	0.3	-0.3	0.8
Stomach or abdominal pain in last month	0.2	0.3	0.7	0.2	-0.9	0.0
Sitting height	0.2	1.5	3.3	1.8	0.1	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.3	0.6	0.8	-0.6	-0.0
Diabetes (self-reported)	0.2	0.3	0.7	0.0	0.6	-0.8
Arm fat percentage (right)	0.2	0.8	1.2	-0.8	0.6	1.1
Hip circumference	0.2	0.8	1.7	0.6	0.5	1.3
Alcohol intake versus 10 years previously	0.2	0.3	0.8	-0.9	-0.0	-0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.3	0.9	0.3	-0.9	0.2
Asthma	0.2	0.4	0.8	-0.9	-0.5	-0.1
Tense / ‘highly strung’	0.2	0.4	0.5	-0.7	-0.5	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	-0.6	0.8	-0.1
Birth weight of first child	0.2	0.4	1.0	0.3	-0.2	1.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	0.8	0.5	0.4
Medication: Paracetamol	0.2	0.3	0.4	-0.6	-0.6	0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.5	0.6	-0.7	0.4
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.3	0.4	-0.2	0.6
Forced vital capacity (FVC), Best measure	0.2	0.6	1.2	-0.0	-1.1	0.7
Leg fat percentage (right)	0.2	0.6	0.9	-0.5	0.8	0.9
Comparative body size at age 10	0.2	0.6	1.6	0.0	-0.5	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	-0.8	0.3	-0.4
Whole body fat mass	0.2	0.8	1.5	0.6	0.7	1.2
Number of full sisters	0.2	0.2	0.4	0.2	0.5	0.6
Chest pain or discomfort	0.2	0.3	0.7	-0.1	-0.8	-0.4
Family relationship satisfaction	0.2	0.3	0.5	-0.5	-0.7	-0.1
Illnesses of siblings: Diabetes	0.2	0.2	0.3	0.2	0.5	0.5
Arm fat percentage (left)	0.2	0.6	1.3	-0.6	0.5	1.1
Ever had bowel cancer screening	0.2	0.2	0.6	0.3	0.8	0.3
Eye problems/disorders: Cataract	0.2	0.2	0.3	0.5	-0.6	-0.3
Mineral and other dietary supplements	0.2	0.3	0.5	0.7	0.1	0.6
Asthma (self-reported)	0.2	0.4	1.0	-1.0	-0.3	-0.3
Commuting to job workplace: Public transport	0.2	0.2	0.5	-0.2	-0.7	-0.3
Illnesses of father: High blood pressure	0.2	0.2	0.5	0.0	-0.7	0.4
Leg fat percentage (left)	0.2	0.9	1.9	-0.2	0.9	1.4
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.3	0.3	-0.5	0.5
Myopia	0.2	0.3	0.6	-0.6	0.8	0.0
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.1	1.0	-0.2	0.4
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	-0.2	0.2	0.6
Schizophrenia (2014)	0.1	0.3	0.7	-0.8	-0.5	-0.1
Blood Eosinophil Count	0.1	0.4	0.7	-0.6	-0.5	-0.8
Blood Platelet Count	0.1	0.8	1.0	1.0	0.9	-0.6
Lung FVC	0.1	0.5	1.2	-1.1	0.2	0.4
Hair Pigment	0.1	2.3	4.1	-0.7	-1.5	2.0
Tanning	0.1	1.1	3.0	-0.4	-0.4	1.7
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	-0.5	-0.0	0.4
Medication: Metformin	0.1	0.2	0.3	0.5	0.5	-0.2
Trunk fat mass	0.1	0.6	1.0	0.4	0.8	1.0
Number of incorrect matches in round	0.1	0.2	0.5	-0.7	0.2	0.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.4	-0.2	-0.5
Forced vital capacity (FVC)	0.1	0.5	1.5	-0.1	-0.1	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.4	-0.2	0.6
Number of live births	0.1	0.2	0.3	0.4	-0.1	-0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.8	-0.9	-0.4	0.3
Lung cancer (father)	0.1	0.1	0.1	0.3	0.3	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.5	-0.7	-0.7	0.0
Standing height	0.1	1.0	2.9	1.7	0.3	0.1
Breastfed as a baby	0.1	0.2	0.2	-0.4	0.4	-0.4
Body fat percentage	0.1	0.4	0.7	-0.2	0.6	0.8
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	-0.1	-0.2	-0.6
Medication for pain relief, constipation, heartburn	0.1	0.3	0.7	0.8	0.2	0.1
Long-standing illness, disability or infirmity	0.1	0.2	0.3	-0.3	0.5	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.2	-0.5	0.0
Illnesses of father: None of the above (group 1)	0.1	0.1	0.3	-0.1	0.1	-0.5
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	0.1	0.7	-0.1
Average weekly champagne plus white wine intake	0.1	0.2	0.4	-0.4	0.2	0.6
Diastolic blood pressure, automated reading	0.1	0.2	0.4	0.6	-0.2	0.5
Bipolar Disorder (2018)	0.0	0.0	0.0	-0.0	-0.1	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	-0.2	-0.1	-0.2
Alzheimer’s Disease (in father)	0.0	0.0	0.1	0.1	0.0	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.1	0.0	0.0	-0.3
Waist Hip Ratio (WHR)	0.0	0.0	0.1	0.3	0.0	-0.2
Systolic Blood Pressure	0.0	0.1	0.2	0.3	-0.5	-0.2
Trunk fat percentage	0.0	0.2	0.3	-0.2	0.3	0.6
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	-0.0	0.1	0.3
Qualifications: College or University degree	0.0	0.2	0.3	0.3	-0.2	-0.6
Medication: Paracetamol	0.0	0.1	0.1	-0.3	-0.2	0.3
Irritability	0.0	0.0	0.1	-0.1	-0.1	-0.3

Hub : Genes

SLC2A1

Models

Trait associations