Hub : Genes

LEPRE1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.0610	0.0280	0.0069	-0.004	NA	-0.003	NA	-0.004	0.85000	NA	5.4e-01	NA	7.1e-01
2	GTEx	Spleen	0.2210	0.0860	0.0063	0.142	NA	0.095	NA	0.091	0.00017	NA	2.0e-03	NA	2.5e-03
3	GTEx	Vagina	0.4950	0.1380	0.0017	-0.002	NA	-0.011	NA	-0.001	0.35000	NA	6.9e-01	NA	3.4e-01
4	YFS	Blood	0.0184	0.0087	0.0029	0.009	0.007	0.016	0.01	0.015	0.00051	0.0012	2.9e-06	0.00018	7.3e-06
5	TCGA	Prostate Adenocarcinoma	0.0748	0.0424	0.0029	0.008	0.024	0.014	NA	0.015	0.04700	0.0015	1.0e-02	NA	9.1e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.7	2.0	-1.0	-0.1	-1.4	-0.4	0.5
Bipolar Disorder or Schizophrenia	0.2	0.4	1.1	-0.2	-0.3	-1.1	-0.8	0.4
Depressed Affect (Nagel 2018)	0.7	1.5	4.6	0.0	2.1	0.6	-0.2	-1.5
Depression (Nagel 2018)	0.4	0.6	1.7	0.9	1.3	-0.0	0.4	0.4
Intelligence (Savage-Jansen 2018)	0.4	1.1	3.0	-0.9	-0.8	1.7	1.0	-0.2
Neuroticism (Nagel 2018)	0.5	1.2	5.9	0.3	2.4	-0.4	0.1	0.1
Schizophrenia (2018)	0.1	0.2	0.5	0.6	-0.3	-0.2	-0.7	0.1
Schizophrenia vs Biploar Disorder	0.3	0.3	0.9	0.2	-0.3	0.6	-0.6	-0.9
Worry (Nagel 2018)	0.8	1.7	5.3	0.5	1.6	-0.4	0.8	2.3
Alzheimer’s Disease (in mother)	2.9	3.3	8.5	-0.8	-0.5	-2.9	-2.6	-0.5
Alzheimer’s Disease (in father)	0.2	0.2	1.1	0.0	-0.2	-1.1	-0.1	0.2
Alzheimer’s Disease (including proxy)	1.7	2.5	7.7	-0.0	-0.4	-2.8	-2.1	-0.1
Crohns Disease (2017)	1.1	2.5	5.6	2.2	2.4	1.2	1.0	0.1
Irritable Bowel Disease (IBD)	0.5	1.3	3.5	0.8	1.0	1.9	0.9	-0.6
Ulcerative Colitis (UC)	0.7	1.3	2.6	-1.6	-1.1	1.5	0.3	-0.6
Major Depression (MDD)	1.3	1.6	4.8	2.2	0.1	1.6	0.7	-0.5
Reaction Time	0.7	1.3	2.2	-1.5	-0.2	-1.2	-1.3	-1.1
Verbal and Numeric Reasoning (VNR)	0.6	1.5	5.6	-0.4	-0.0	2.4	1.2	-0.7
Breast Cancer	0.8	1.9	8.1	-0.1	-0.2	-1.1	0.6	2.8
Ovarian Cancer	0.3	0.4	0.8	-0.4	0.6	-0.4	0.9	0.9
Prostate Cancer	1.1	1.5	4.0	1.2	0.0	0.9	1.1	2.0
Age at First Birth	1.1	1.6	4.5	1.3	-0.7	-1.0	0.3	2.1
Bipolar Disorder (2011)	0.4	0.4	1.5	-0.6	-0.1	-0.4	-0.3	-1.2
Body Mass Index (BMI) (2010)	0.2	0.2	0.8	0.9	0.0	0.1	-0.2	0.4
Coronary Artery Disease (CAD)	0.5	0.6	1.4	1.2	-0.3	-0.6	-0.8	-0.8
Crohns Disease (2012)	2.4	3.9	7.2	2.7	2.7	1.6	1.5	0.7
Mean Putamen Volume	0.3	0.3	1.0	0.6	0.1	-0.1	-1.0	0.6
Fasting Glucose	0.3	0.4	1.1	-0.6	0.5	-1.0	-0.4	0.5
HbA1C	0.5	0.6	1.5	1.2	0.7	0.0	0.8	0.4
HDL Cholesterol	0.7	1.2	2.4	1.5	0.6	-1.6	0.2	1.1
LDL Cholesterol	1.0	1.5	3.1	-1.2	-1.8	-0.9	-1.6	0.0
Lupus	0.2	0.4	0.8	-0.5	-0.4	0.9	0.2	-0.8
Neuroticism (2016)	1.1	1.5	5.8	0.2	2.4	0.9	0.6	-0.8
Primary Biliary Cirrhosis	0.6	0.9	1.4	1.2	-0.1	1.1	1.2	-0.7
Rheumatoid Arthritis	0.1	0.2	0.4	0.6	-0.2	0.6	-0.3	-0.2
Schizophrenia (2014)	0.1	0.3	0.7	0.0	-0.6	-0.1	-0.8	-0.7
Triglycerides	0.1	0.2	0.4	-0.7	-0.6	0.6	-0.0	-0.3
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.5	0.5	0.4	-1.6	-1.2	0.3
Ulcerative Colitis	1.2	1.8	6.3	0.3	-2.5	1.4	0.0	-0.7
Blood Eosinophil Count	0.6	5.0	15.3	3.9	1.5	1.6	-1.4	-1.7
Blood Platelet Count	0.3	3.9	14.4	-1.4	0.2	0.8	-1.5	-3.8
Blood Red Count	0.1	1.2	2.1	-0.9	1.1	-0.4	-1.2	-1.4
Blood White Count	1.6	11.8	31.0	5.6	4.6	1.9	1.8	0.0
Heel T-Score	0.3	2.6	6.4	-2.5	-1.5	-1.1	-1.1	-1.3
BMI	0.5	2.8	11.1	0.5	-0.8	0.7	-1.1	-3.3
Height	0.4	7.2	15.1	-3.9	-3.4	0.2	-1.7	-2.5
Waist Hip Ratio (WHR)	0.1	0.5	1.2	-0.6	0.7	1.1	0.5	-0.4
Systolic Blood Pressure	0.4	2.0	7.5	-1.4	-2.7	0.1	-0.7	0.2
Smoking Status	1.5	3.5	6.6	1.2	1.9	2.6	2.4	0.1
Allergy or Eczema	0.9	2.4	4.2	1.6	0.6	1.0	2.0	2.0
Cardiovascular Disease	1.3	4.3	7.4	-1.8	-2.3	-0.8	-2.1	-2.7
Hypothyroidism (self reported)	3.5	8.0	14.6	1.8	3.3	3.8	3.2	-0.9
Respiratory disease	0.5	1.0	2.3	0.4	1.3	-0.1	1.0	1.5
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.5	1.6	0.8	0.8	1.2	-0.1
Lung FEV1/FVC ratio	0.2	1.0	3.1	-0.5	-0.2	1.2	1.8	-0.4
Lung FVC	0.2	0.8	2.7	1.0	1.6	0.3	0.7	-0.1
Neuroticism	0.5	1.2	2.6	-0.4	1.3	1.6	1.2	0.4
Chronotype (morning person)	0.3	0.6	1.8	-1.3	-0.1	-0.1	0.6	1.0
Hair Pigment	0.2	6.8	21.0	2.1	4.6	1.3	2.5	-0.7
Tanning	0.1	1.0	2.0	0.5	1.4	1.0	1.4	0.3
Hand grip strength (left)	0.2	0.6	1.6	-0.9	-0.2	1.3	0.1	-0.6
Number of treatments/medications taken	0.4	0.7	2.2	-0.9	0.1	0.2	0.5	-1.5
Average weekly spirits intake	0.9	1.2	2.8	0.7	-0.9	-0.5	-1.2	-1.7
Sensitivity / hurt feelings	0.7	1.2	3.0	0.7	-0.5	-1.1	-1.7	-1.0
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.9	0.8	0.7	0.1	0.1	1.0
Hearing difficulty/problems: Yes	0.7	1.0	3.3	-0.6	-1.8	0.0	-1.2	-0.3
Relative age of first facial hair	0.2	0.4	0.8	-0.9	-0.6	0.7	0.4	-0.1
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.4	-0.0	-0.5	0.1	-0.5	-0.6
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.8	-0.8	-1.4	-1.3	-0.5	0.5
Ever had hysterectomy (womb removed)	0.4	0.4	0.9	-0.7	0.4	-0.9	0.6	-0.7
Systolic blood pressure, automated reading	0.2	0.7	2.4	-0.6	-1.6	-0.1	-0.2	-0.7
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.4	-0.1	0.4	1.2	1.1	-0.3
Angina	0.9	1.2	2.2	-1.1	1.1	1.3	-0.2	-1.5
Medication for hormone replacement therapy	0.5	0.6	1.7	-0.8	-0.8	0.2	-0.3	-1.3
Vitamin and mineral supplements	0.6	0.7	3.4	-0.3	1.9	0.1	0.4	-0.3
Supplements: Zinc	0.5	0.5	1.7	-0.6	-1.3	-0.0	-0.6	0.4
Medication: Co-codamol	0.3	0.3	1.0	0.2	-1.0	-0.5	-0.7	-0.1
Medication: Metformin	0.2	0.3	0.5	0.7	0.6	-0.1	0.6	-0.2
Diabetes (father)	0.1	0.1	0.2	-0.2	0.3	-0.0	-0.4	0.2
Diabetes (mother)	0.4	0.4	1.3	-0.4	1.1	0.3	0.7	-0.4
Severe depression (siblings)	1.0	1.1	1.9	0.9	0.3	-1.1	-1.3	-1.4
Pack years adult smoking proportion	0.5	0.8	1.6	-1.0	-0.4	1.3	-0.4	-1.0
Impedance of leg (right)	0.4	2.2	4.4	1.0	1.8	-0.7	1.3	2.1
Leg fat-free mass (left)	0.9	5.0	12.9	-1.8	-1.8	0.8	-2.2	-3.6
Trunk fat percentage	0.7	3.0	13.1	-0.3	-0.6	0.4	-1.0	-3.6
Hand grip strength (right)	0.2	0.6	1.9	-0.4	0.4	1.4	0.8	-0.2
Townsend deprivation index at recruitment	1.2	1.7	4.6	-1.8	-0.5	0.5	-0.3	-2.1
Current tobacco smoking	0.4	0.7	2.1	1.4	1.1	-0.2	0.3	0.1
Average weekly fortified wine intake	0.6	0.7	1.0	-1.0	-0.9	-0.8	-0.9	0.5
Maternal smoking around birth	0.8	1.2	4.1	-2.0	1.0	-0.2	0.7	-0.4
Fed-up feelings	0.6	1.0	3.2	-0.4	1.2	0.3	-0.5	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.5	1.6	-0.0	1.3	0.2	0.4	0.7
Relative age voice broke	0.7	1.1	2.5	0.0	-0.9	0.9	1.1	1.6
Taking other prescription medications	1.1	1.7	3.4	0.6	1.2	1.8	1.8	0.4
Age when periods started (menarche)	0.3	0.6	1.9	-0.4	0.7	-1.4	0.5	0.6
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.0	-0.9	-0.6	-1.0	-0.8	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.1	-0.9	-1.0	-0.1	-0.6	0.2
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	3.5	-0.1	1.1	1.5	1.9	-0.0
Qualifications: CSEs or equivalent	0.7	0.9	2.7	-1.0	-0.2	0.1	-0.9	-1.6
Serious illness, injury or assault to yourself	0.8	0.9	3.3	0.0	-1.1	1.8	0.3	-0.0
High blood pressure	2.3	6.4	8.8	-3.0	-2.9	-1.5	-2.3	-2.8
Hayfever, allergic rhinitis or eczema	1.0	2.1	4.0	1.4	1.1	0.8	2.0	1.6
Multivitamins +/- minerals	0.3	0.4	1.7	0.1	-1.3	-0.1	-0.4	-0.2
Stomach or abdominal pain in last month	1.5	1.8	3.5	-1.0	-1.9	-0.6	-1.8	-0.9
Supplements: Glucosamine	0.2	0.3	0.7	-0.1	-0.3	-0.0	-0.7	-0.8
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	0.3	0.2	-0.0	-0.2	-0.4
Medication: Atenolol	1.9	2.4	5.9	-1.6	-0.9	-0.9	-1.5	-2.4
Medication: Levothyroxine sodium	2.5	4.3	11.1	0.1	1.9	3.3	2.1	-1.6
Sitting height	0.2	1.5	2.7	-1.2	-0.6	1.4	-0.9	-1.6
Chronic bronchitis/emphysema (father)	0.4	0.4	1.0	1.0	-0.3	-0.5	-0.9	0.0
High blood pressure (mother)	0.5	0.6	1.9	0.6	-1.4	-0.3	-0.6	0.7
Body mass index (BMI)	1.0	4.4	16.1	0.1	-1.4	1.1	-1.7	-4.0
Impedance of leg (left)	0.5	2.5	5.2	1.3	1.5	-0.7	1.7	2.3
Leg predicted mass (left)	0.9	5.0	12.9	-1.8	-1.8	0.8	-2.2	-3.6
Trunk fat mass	1.0	4.3	17.5	-0.5	-1.0	0.7	-1.5	-4.2
Waist circumference	1.1	4.0	13.5	-0.5	-1.7	1.1	-1.5	-3.7
Number of incorrect matches in round	1.1	1.8	3.2	1.7	-0.5	-1.6	-1.8	-0.5
Past tobacco smoking	1.3	2.5	5.3	0.5	-1.3	-2.3	-2.2	0.0
Alcohol usually taken with meals	1.1	1.8	4.2	-2.0	-1.8	-1.1	-0.5	0.2
Nervous feelings	0.4	0.7	1.1	0.4	1.0	-1.0	-0.8	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.6	0.5	0.9	0.4	0.8	1.3
Hearing difficulty/problems with background noise	0.8	1.3	3.9	-0.9	-2.0	1.3	0.4	0.1
Hair/balding pattern: Pattern 2	1.8	2.3	4.7	-2.1	-2.2	0.4	-0.9	-1.1
Had menopause	1.1	1.4	2.2	-1.0	-1.4	-0.8	-0.9	-1.5
Had other major operations	0.3	0.4	0.8	0.6	0.9	-0.6	0.7	0.1
Forced vital capacity (FVC)	0.1	0.3	1.0	-0.4	0.6	-0.3	-1.0	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.1	-0.4	-0.9	1.1	0.5	0.8
Ever unenthusiastic/disinterested for a whole week	2.1	2.6	5.7	0.5	2.0	2.4	1.7	-0.3
Qualifications: None of the above	0.3	0.7	1.9	-1.1	0.7	-0.0	0.1	-1.4
Financial difficulties in last 2 years	0.7	0.9	3.0	1.0	0.0	0.6	-0.3	-1.7
Mouth/teeth dental problems	1.0	1.6	3.0	0.0	-1.3	-1.7	-1.6	0.8
Heart attack	0.1	0.1	0.3	-0.1	0.5	-0.4	0.1	0.4
Allergy	0.4	0.9	2.3	0.5	0.1	-0.4	-1.4	-1.5
Pain all over the body in last month	1.0	1.1	2.0	0.4	1.3	1.4	1.1	-0.7
Diabetes (self-reported)	0.1	0.2	0.4	-0.1	-0.1	-0.5	0.6	0.2
Hayfever/allergic rhinitis (self-reported)	2.1	2.8	5.3	2.0	0.4	0.1	2.0	2.3
Medication: Ramipril	1.6	2.0	3.8	-1.4	-1.3	-2.0	-1.5	-0.4
Medication: Simvastatin	0.5	0.7	2.5	0.0	0.3	1.0	1.6	-0.0
Fluid intelligence score	0.4	0.8	2.2	-0.3	-0.5	1.5	1.0	0.4
Illnesses of siblings	1.4	2.0	5.1	-0.4	0.5	0.8	2.0	2.2
Neuroticism score	0.1	0.2	0.8	-0.0	0.9	0.2	-0.5	-0.1
Weight	1.1	5.5	18.4	-0.9	-1.9	1.2	-1.8	-4.3
Impedance of arm (right)	0.4	2.0	3.7	-1.3	1.3	-0.4	1.7	1.9
Arm fat percentage (right)	1.2	4.9	18.7	-0.5	-1.1	1.1	-1.7	-4.3
Trunk fat-free mass	0.6	3.7	9.7	-1.2	-1.7	1.1	-1.8	-3.1
Hip circumference	1.0	4.2	10.8	-0.0	-2.4	1.1	-1.7	-3.3
Time employed in main current job	0.6	0.7	1.8	1.0	0.5	0.5	0.5	1.3
Alcohol intake versus 10 years previously	1.1	1.7	4.9	-0.7	1.4	2.2	0.7	-0.8
Father’s age at death	1.3	1.7	6.1	0.2	-0.6	-2.5	-1.2	0.8
Worrier / anxious feelings	0.3	0.6	1.4	0.6	0.3	-1.2	-1.0	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.3	0.7	-0.0	1.1	-0.2	-0.0
Falls in the last year	1.5	2.0	4.3	-0.4	-0.7	-1.5	-2.1	-1.7
Hair/balding pattern: Pattern 3	0.8	1.1	3.6	0.6	-0.5	-1.9	-1.2	-0.1
Number of live births	1.3	1.8	3.8	1.9	1.6	0.8	1.5	0.1
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.3	-0.0	0.6	-0.2	-0.4	0.4
Pulse rate	1.6	2.6	9.9	0.1	3.1	0.2	1.8	-0.4
Happiness	1.0	1.2	3.5	1.1	-0.8	-0.6	-1.9	-0.5
Noisy workplace	0.5	0.6	1.9	-1.4	0.4	-1.1	-0.1	-0.2
Qualifications: A levels/AS levels or equivalent	0.9	2.0	3.9	1.5	-1.4	1.2	0.8	2.0
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.3	-1.1	-0.4	0.2	-0.7	-0.8
Mouth/teeth dental problems: Dentures	0.4	0.7	1.1	-0.9	1.0	0.9	1.1	0.2
Asthma	0.0	0.0	0.1	0.1	-0.2	0.1	-0.2	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	3.8	-0.4	1.0	-1.9	-0.4	0.7
Medication: Cholesterol lowering	0.6	0.9	3.4	-0.7	-0.6	0.4	0.0	-1.8
Depression (self-reported)	0.1	0.1	0.2	0.4	-0.5	-0.4	0.1	0.3
Medication: Lansoprazole	0.8	0.9	3.2	-1.8	-0.2	0.4	0.2	-1.1
Prospective memory result	0.5	0.6	1.9	-0.6	1.4	-0.4	0.8	-0.1
Lung cancer (father)	0.4	0.4	1.3	-0.7	-0.3	-0.1	0.5	1.1
Illnesses of mother	0.4	0.5	1.4	-0.4	0.5	1.2	0.8	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.7	-0.8	-0.0	0.5	0.2	0.1
Pulse wave Arterial Stiffness index	0.5	0.6	1.9	0.2	0.8	-1.4	-0.7	-0.4
Impedance of arm (left)	0.4	1.9	4.8	-0.7	0.9	-0.5	1.7	2.2
Arm fat mass (right)	1.2	5.0	18.8	-0.2	-1.3	1.1	-1.8	-4.3
Trunk predicted mass	0.6	3.6	9.1	-1.2	-1.7	1.1	-1.7	-3.0
Standing height	0.2	1.7	5.8	-2.4	-1.3	0.4	-0.4	-0.9
Length of working week for main job	0.8	0.9	2.6	0.3	1.6	1.3	0.3	-0.2
Exposure to tobacco smoke at home	0.9	1.0	3.5	-0.3	-0.9	-0.7	0.4	1.9
Breastfed as a baby	0.5	0.6	1.7	-0.4	-1.3	-0.8	-0.3	0.7
Tense / ‘highly strung’	0.4	0.7	2.0	-0.5	0.3	-0.9	-0.7	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	5.2	1.2	2.3	0.8	0.1	-1.1
Hair/balding pattern: Pattern 4	1.3	3.1	6.5	0.8	1.6	0.6	2.5	2.3
Birth weight of first child	0.1	0.2	0.6	0.1	-0.5	0.5	-0.1	-0.8
Peak expiratory flow (PEF)	0.4	0.9	2.0	0.9	0.5	1.4	0.7	1.0
Pulse wave reflection index	1.3	1.5	4.5	-1.1	-0.6	-2.1	-1.3	0.2
Ever highly irritable/argumentative for 2 days	3.0	3.6	6.7	1.9	2.6	0.7	1.7	2.2
Loud music exposure frequency	0.7	0.7	1.3	1.1	0.5	1.1	0.8	0.4
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	4.4	2.1	0.1	0.7	0.7	-0.6
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	4.2	1.0	-0.1	0.6	-1.2	-2.0
Blood clot in the leg (DVT)	0.6	0.7	2.8	-1.7	-0.5	0.3	-0.2	-0.8
Medication: Paracetamol	0.6	1.0	1.6	-1.3	0.9	-1.3	-0.0	0.9
Headache pain in last month	0.2	0.3	0.5	-0.6	-0.7	0.5	0.6	0.2
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	2.1	1.4	1.4	1.1	0.8	1.3
Glaucoma (self-reported)	1.5	1.8	3.8	1.0	1.3	2.0	1.5	-0.4
Gout (self-reported)	0.9	1.2	2.3	-1.5	-0.8	-1.1	-1.4	0.2
Hypothyroidism/myxoedema (self-reported)	4.8	9.4	21.4	1.5	3.1	4.6	3.3	-1.6
Medication: Amlodipine	0.5	0.7	2.0	-1.2	0.3	-0.2	-0.3	-1.4
Medication: Ventolin 100micrograms inhaler	0.9	1.2	3.1	0.7	1.8	1.0	0.5	-1.1
Birth weight	0.9	1.9	4.8	1.3	-0.3	2.2	1.1	-1.5
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.1	0.3	1.3	0.8	1.4	-0.2
High blood pressure (siblings)	2.3	3.3	6.1	-0.6	-2.1	-0.3	-2.4	-2.5
Forced vital capacity (FVC), Best measure	0.1	0.4	0.9	-1.0	-0.3	0.4	-0.6	-0.7
Body fat percentage	1.0	3.9	16.8	-0.1	-0.8	0.7	-1.2	-4.1
Leg fat percentage (right)	1.2	4.4	18.2	0.7	-0.4	1.2	-1.2	-4.3
Arm fat-free mass (right)	0.7	3.5	9.5	-0.4	-1.8	0.7	-2.0	-3.1
Exposure to tobacco smoke outside home	1.3	1.7	3.6	1.7	-0.3	-1.9	-0.7	1.4
Comparative body size at age 10	1.0	2.7	7.2	1.9	0.8	2.7	1.3	-0.5
Number of full brothers	0.5	0.6	1.3	0.7	-0.0	0.5	-1.1	-0.9
Worry too long after embarrassment	0.3	0.5	1.4	0.4	0.7	-1.2	0.5	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.9	0.0	0.9	0.3	0.5	0.6
Wheeze or whistling in the chest in last year	0.3	0.5	1.3	-1.1	-0.4	0.8	0.1	-0.3
Number of children fathered	0.4	0.4	0.8	0.9	0.7	0.8	0.5	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	-0.8	-0.5	0.1	0.2	0.1
Age at first live birth	0.2	0.3	0.6	0.4	0.8	-0.7	-0.2	-0.0
Pulse wave peak to peak time	0.7	0.8	2.3	-0.2	-0.8	1.5	0.9	0.5
Health satisfaction	0.1	0.1	0.3	0.6	-0.4	0.2	-0.2	-0.4
Shortness of breath walking on level ground	0.6	0.7	1.2	-0.9	-1.1	-0.0	-0.7	-1.1
Qualifications: College or University degree	0.7	2.2	4.6	1.1	-0.3	2.1	2.1	0.7
Eye problems/disorders: None of the above	0.3	0.3	0.5	0.6	0.6	-0.7	-0.5	-0.3
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.4	1.2	-0.8	0.3	0.5	1.5
Emphysema/chronic bronchitis	1.0	1.2	4.0	-2.0	-1.0	0.0	-0.3	-0.9
Medication for pain relief, constipation, heartburn	0.5	0.9	3.5	1.9	-0.6	0.4	-0.7	0.3
Neck or shoulder pain in last month	0.8	1.1	3.0	-0.1	-0.3	-1.3	-1.7	-0.7
Medication: Blood pressure	1.4	2.4	4.6	-2.1	-1.9	-0.6	-0.9	-1.6
Angina (self-reported)	1.0	1.3	2.5	-1.4	0.8	1.2	-0.3	-1.6
Migraine (self-reported)	0.5	0.6	2.1	-0.3	-0.0	0.5	0.7	1.4
Medication: Ibuprofen	0.7	0.9	3.1	-0.1	0.9	-1.7	0.1	0.6
Medication: Allopurinol	1.9	2.5	4.5	-1.2	-2.1	-1.7	-1.9	0.7
Medication: Omeprazole	1.3	1.5	3.8	-1.6	-1.9	1.1	0.2	-0.2
Medication: Seretide 50 evohaler	0.5	0.6	1.5	-0.1	-0.9	-0.2	-0.6	-1.2
Mean time to correctly identify matches	0.5	1.0	2.5	-1.6	-0.3	-0.9	-0.7	-1.0
Heart disease (mother)	0.5	0.7	3.0	-1.7	0.5	-0.1	0.2	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	6.2	0.4	0.0	0.6	2.5	1.6
Whole body fat mass	1.1	4.7	18.6	-0.4	-1.2	0.7	-1.7	-4.3
Leg fat mass (right)	1.5	5.6	22.3	-0.0	-1.0	0.9	-2.0	-4.7
Arm predicted mass (right)	0.6	3.2	8.6	-0.3	-1.7	0.6	-2.0	-2.9
Pulse rate, automated reading	0.9	2.9	10.8	-0.6	0.6	-3.3	-1.7	-0.5
Alcohol intake frequency.	0.2	0.4	1.3	-0.3	0.6	1.2	0.6	0.0
Comparative height size at age 10	0.4	2.3	5.7	-2.4	-1.5	0.4	-0.8	-1.6
Number of full sisters	0.8	0.9	2.1	-1.4	0.7	0.6	0.2	-1.3
Suffer from ‘nerves’	0.7	1.1	2.5	0.3	1.6	-0.3	0.5	1.5
Overall health rating	0.7	1.5	3.2	-1.0	-1.4	-0.8	-1.8	-0.5
Chest pain or discomfort	0.4	0.6	1.6	0.2	0.3	1.2	1.3	-0.2
Had major operations	0.6	0.7	1.2	-0.5	-0.9	-1.1	-1.1	0.1
Age at last live birth	0.2	0.3	0.6	0.7	0.7	0.0	0.3	-0.4
Family relationship satisfaction	0.6	0.8	2.7	0.9	-0.0	1.6	-0.4	-0.3
Leg pain on walking	0.7	0.8	1.5	-1.2	-0.7	0.2	-0.8	-1.2
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	3.1	-0.3	1.6	-0.2	0.9	1.8
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.3	1.2	1.1	0.1	-0.1	-0.3
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.3	0.1	1.2	-0.8	1.5	1.8
Medication: Aspirin	1.6	2.1	2.9	-1.7	-0.8	1.7	1.2	-1.7
Supplements: Vitamin C	0.3	0.4	0.5	0.6	0.6	0.7	0.7	0.5
Knee pain experienced in last month	0.9	1.4	2.7	1.2	0.1	0.4	-1.6	-1.6
Hypertension (Self-reported)	2.7	7.5	11.0	-3.3	-3.1	-1.9	-2.5	-2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.8	-0.3	-0.8	0.6	0.6	-0.9
Illnesses of father: Heart disease	1.8	2.5	3.9	1.8	2.0	1.5	1.7	-0.4
Illnesses of siblings: Diabetes	0.6	0.7	1.6	0.4	1.2	0.3	1.2	0.4
Smoking status: Previous	1.9	2.8	7.5	-0.2	1.3	2.7	2.2	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.4	-0.5	0.5	0.1	-0.6	-1.5
Whole body fat-free mass	0.8	4.4	11.2	-1.5	-1.9	1.0	-2.0	-3.3
Leg fat-free mass (right)	0.8	4.5	11.3	-1.7	-1.9	0.9	-2.0	-3.4
Arm fat percentage (left)	1.1	4.2	16.4	-0.1	-1.1	1.1	-1.4	-4.0
Average weekly red wine intake	0.6	0.9	1.3	-1.2	-1.0	-1.1	-1.0	0.5
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.4	0.6	1.6	-0.2	0.0	0.7
Mood swings	0.5	0.9	2.9	-0.2	1.7	1.1	0.1	-0.4
Loneliness, isolation	0.6	0.8	1.3	0.3	1.1	-0.7	-1.0	-1.0
Long-standing illness, disability or infirmity	0.8	1.2	3.0	0.1	1.7	1.2	1.1	-0.8
Ever had bowel cancer screening	1.1	1.3	4.1	-0.9	-0.1	-2.0	-1.2	-0.3
Diabetes diagnosed by doctor	0.2	0.3	0.5	0.5	0.4	-0.6	0.7	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.9	-0.9	-0.1	1.2	0.3	-1.4
Friendships satisfaction	1.2	1.5	2.9	1.4	1.0	1.7	1.2	0.3
Qualifications: nursing, teaching	0.8	1.2	3.5	1.9	0.4	1.2	0.9	0.3
Commuting to job workplace: Walk	1.1	1.2	3.5	-1.9	-0.9	0.5	0.9	0.7
Eye problems/disorders: Cataract	0.6	0.7	2.4	-0.5	-0.9	-0.4	0.2	1.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.9	-0.4	0.4	0.1	-0.3	-1.0
Medication for cholesterol	1.2	1.8	2.8	1.1	1.5	0.7	1.6	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.6	-0.4	-0.8	-0.3	-0.8	-0.7
Back pain experienced in last month	0.3	0.4	1.3	0.7	0.4	0.4	-0.2	-1.1
Mineral and other dietary supplements	0.4	0.5	0.9	0.9	-0.1	0.8	0.6	0.9
Breast cancer (self-reported)	0.6	0.7	1.3	1.0	0.9	1.1	0.6	0.4
Asthma (self-reported)	0.0	0.0	0.1	0.3	0.0	0.3	0.1	0.2
Osteoporosis (self-reported)	0.1	0.2	0.5	0.0	0.1	-0.2	0.4	0.7
Osteoarthritis (self-reported)	1.4	1.8	3.7	0.2	-1.0	-1.7	-1.9	-1.1
Medication: Aspirin	1.4	1.8	2.9	-1.7	-1.1	1.4	1.1	-1.3
Medication: Gliclazide	0.3	0.4	1.0	-0.3	-0.3	-1.0	-0.7	-0.5
Illnesses of father: None of the above (group 1)	0.1	0.2	0.6	0.1	-0.4	0.8	-0.0	0.1
Smoking status: Current	0.2	0.3	0.8	0.9	0.8	-0.2	0.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.4	-0.1	-0.1	0.6	0.3	-0.3
Whole body water mass	0.7	4.1	11.4	-1.2	-1.7	1.1	-1.9	-3.4
Leg predicted mass (right)	0.8	4.5	11.2	-1.8	-1.9	0.9	-1.9	-3.3
Arm fat mass (left)	1.4	5.6	21.2	0.1	-1.3	1.3	-1.9	-4.6
Number of self-reported non-cancer illnesses	0.5	0.8	2.5	-1.2	-0.0	-0.5	-0.1	-1.6
Average weekly champagne plus white wine intake	1.4	1.9	5.5	-0.0	-1.8	-1.0	-2.3	-0.4
Miserableness	0.9	1.6	4.6	-0.8	0.8	0.4	-1.3	-2.1
Guilty feelings	1.0	1.5	4.0	1.0	2.0	1.2	1.0	0.2
Wears glasses or contact lenses	1.1	1.3	3.7	0.2	1.5	-0.2	1.9	0.7
Ever taken oral contraceptive pill	0.9	1.0	2.2	1.0	0.9	1.5	0.9	0.3
Hearing aid user	1.0	1.1	3.5	0.1	-0.5	1.9	0.2	-1.3
Mother’s age at death	1.5	1.9	5.3	0.6	-1.8	-0.6	0.3	2.3
Financial situation satisfaction	2.3	2.8	5.7	1.6	1.6	2.4	0.9	-1.7
Tinnitus: Yes, now most or all of the time	0.9	1.1	3.0	-0.6	-1.7	0.1	-1.0	-1.0
Commuting to job workplace: Public transport	1.3	1.6	3.2	-0.4	-1.5	-0.2	1.8	1.6
Eye problems/disorders: Glaucoma	1.1	1.4	2.4	0.4	1.5	1.6	1.4	-0.2
Medication: Blood pressure	2.6	5.0	8.0	-1.9	-2.5	-1.6	-2.8	-2.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.0	-0.2	-1.0	-0.2	-0.2	0.6
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.2	0.3	0.8	-1.1	-0.6	-0.6
High cholesterol (Self-reported)	0.2	0.4	1.1	0.5	-0.1	0.2	0.8	-1.0
Medication: Bendroflumethiazide	0.4	0.6	1.5	-1.1	0.2	-0.3	1.2	0.1
Medication: Paracetamol	0.5	0.7	1.4	-0.9	0.6	-1.0	0.5	1.2
Medication: Lisinopril	2.2	2.8	7.5	-1.6	-1.3	-0.0	-1.5	-2.7
Medication: Atorvastatin	0.9	1.2	3.4	-0.4	-0.2	-0.9	-1.2	-1.8
Illnesses of father: High blood pressure	0.4	0.5	1.6	-0.5	-1.3	0.4	-0.4	0.3
Alcohol drinker status: Never	0.3	0.4	0.7	0.1	0.7	-0.4	0.7	0.9
Ever smoked	1.6	2.8	5.5	0.6	2.1	1.9	2.4	-0.2
Basal metabolic rate	1.0	5.5	15.4	-1.3	-2.0	1.0	-2.3	-3.9
Leg fat percentage (left)	1.1	3.9	16.0	0.8	-0.7	1.1	-1.0	-4.0
Arm fat-free mass (left)	0.9	4.8	13.0	-0.8	-2.0	0.7	-2.4	-3.6
Number of operations (self-reported)	0.2	0.3	0.8	-0.5	0.9	-0.5	0.0	-0.5
Average weekly beer plus cider intake	0.6	0.8	1.3	-0.8	0.7	0.8	-0.9	-1.1
Irritability	0.5	0.8	2.5	-0.6	0.3	-0.6	-1.6	-0.8
Risk taking	0.4	0.6	1.5	1.2	0.3	1.1	0.5	0.4
Ever had prostate specific antigen (PSA) test	1.2	1.4	3.0	-1.6	-1.7	-1.2	-0.2	0.3
Fractured/broken bones in last 5 years	3.2	4.1	11.2	0.3	0.1	2.0	3.4	2.2
Age started oral contraceptive pill	1.0	1.3	3.1	-0.8	-0.5	-1.8	-1.3	-0.7
Diastolic blood pressure, automated reading	0.7	2.2	7.8	-0.6	-2.8	-1.1	-1.0	-0.7
Ever depressed for a whole week	4.0	5.0	7.5	2.5	2.2	2.7	2.5	0.4
Unable to work because of sickness or disability	0.6	0.8	2.5	-0.4	1.6	-0.8	0.5	0.6
Commuting to job workplace: Cycle	0.7	0.8	2.7	-1.0	-1.6	0.2	-0.6	0.1
Myopia	0.6	0.9	1.9	-0.7	-0.1	1.4	1.0	-1.0
Vascular/heart problems diagnosed by doctor	2.7	7.4	11.2	3.3	2.9	1.6	2.4	3.1
Cholesterol lowering medication	0.1	0.1	0.2	-0.4	-0.1	0.1	0.2	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	2.8	-1.6	-1.2	1.7	0.8	-0.4
Pain experienced in last month	1.7	2.9	7.5	-0.2	0.9	0.8	2.7	2.3
Supplements: Calcium	2.3	2.6	4.9	-1.7	-2.2	-1.1	0.6	1.8
Basal cell carcinoma (self-reported)	0.5	0.6	2.0	-0.3	0.8	0.3	1.4	0.5
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	0.1	0.2	-0.0	-0.1	0.1
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.8	-1.7	-0.6	0.1	-0.2	-0.7
Heart disease (siblings)	0.7	0.9	3.7	0.2	1.9	-0.3	0.2	-0.7
Alcohol drinker status: Previous	0.7	0.8	1.8	0.3	0.6	0.4	1.4	1.2
Pack years of smoking	0.6	1.0	2.2	-1.5	-0.5	1.1	-0.2	-1.1
Impedance of whole body	0.4	2.1	5.6	0.2	1.2	-1.0	1.5	2.4
Leg fat mass (left)	1.3	5.0	19.2	0.2	-1.2	1.0	-1.8	-4.4
Arm predicted mass (left)	0.9	4.4	12.8	-0.5	-1.8	0.7	-2.3	-3.6