TWAS hub - LEPRE1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.0610	0.0280	0.0069	-0.004	NA	-0.003	NA	-0.004	0.85000	NA	5.4e-01	NA	7.1e-01
2	GTEx	Spleen	0.2210	0.0860	0.0063	0.142	NA	0.095	NA	0.091	0.00017	NA	2.0e-03	NA	2.5e-03
3	GTEx	Vagina	0.4950	0.1380	0.0017	-0.002	NA	-0.011	NA	-0.001	0.35000	NA	6.9e-01	NA	3.4e-01
4	YFS	Blood	0.0184	0.0087	0.0029	0.009	0.007	0.016	0.01	0.015	0.00051	0.0012	2.9e-06	0.00018	7.3e-06
5	TCGA	Prostate Adenocarcinoma	0.0748	0.0424	0.0029	0.008	0.024	0.014	NA	0.015	0.04700	0.0015	1.0e-02	NA	9.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Hypothyroidism/myxoedema (self-reported)	4.8	9.4	21.4	1.5	3.1	4.6	3.3	-1.6
Ever depressed for a whole week	4.0	5.0	7.5	2.5	2.2	2.7	2.5	0.4
Hypothyroidism (self reported)	3.5	8.0	14.6	1.8	3.3	3.8	3.2	-0.9
Fractured/broken bones in last 5 years	3.2	4.1	11.2	0.3	0.1	2.0	3.4	2.2
Ever highly irritable/argumentative for 2 days	3.0	3.6	6.7	1.9	2.6	0.7	1.7	2.2
Alzheimer’s Disease (in mother)	2.9	3.3	8.5	-0.8	-0.5	-2.9	-2.6	-0.5
Hypertension (Self-reported)	2.7	7.5	11.0	-3.3	-3.1	-1.9	-2.5	-2.7
Vascular/heart problems diagnosed by doctor	2.7	7.4	11.2	3.3	2.9	1.6	2.4	3.1
Medication: Blood pressure	2.6	5.0	8.0	-1.9	-2.5	-1.6	-2.8	-2.2
Medication: Levothyroxine sodium	2.5	4.3	11.1	0.1	1.9	3.3	2.1	-1.6
Crohns Disease (2012)	2.4	3.9	7.2	2.7	2.7	1.6	1.5	0.7
High blood pressure	2.3	6.4	8.8	-3.0	-2.9	-1.5	-2.3	-2.8
High blood pressure (siblings)	2.3	3.3	6.1	-0.6	-2.1	-0.3	-2.4	-2.5
Financial situation satisfaction	2.3	2.8	5.7	1.6	1.6	2.4	0.9	-1.7
Supplements: Calcium	2.3	2.6	4.9	-1.7	-2.2	-1.1	0.6	1.8
Medication: Lisinopril	2.2	2.8	7.5	-1.6	-1.3	-0.0	-1.5	-2.7
Ever unenthusiastic/disinterested for a whole week	2.1	2.6	5.7	0.5	2.0	2.4	1.7	-0.3
Hayfever/allergic rhinitis (self-reported)	2.1	2.8	5.3	2.0	0.4	0.1	2.0	2.3
Medication: Atenolol	1.9	2.4	5.9	-1.6	-0.9	-0.9	-1.5	-2.4
Medication: Allopurinol	1.9	2.5	4.5	-1.2	-2.1	-1.7	-1.9	0.7
Smoking status: Previous	1.9	2.8	7.5	-0.2	1.3	2.7	2.2	-0.2
Hair/balding pattern: Pattern 2	1.8	2.3	4.7	-2.1	-2.2	0.4	-0.9	-1.1
Illnesses of father: Heart disease	1.8	2.5	3.9	1.8	2.0	1.5	1.7	-0.4
Alzheimer’s Disease (including proxy)	1.7	2.5	7.7	-0.0	-0.4	-2.8	-2.1	-0.1
Pain experienced in last month	1.7	2.9	7.5	-0.2	0.9	0.8	2.7	2.3
Blood White Count	1.6	11.8	31.0	5.6	4.6	1.9	1.8	0.0
Medication: Ramipril	1.6	2.0	3.8	-1.4	-1.3	-2.0	-1.5	-0.4
Pulse rate	1.6	2.6	9.9	0.1	3.1	0.2	1.8	-0.4
Medication: Aspirin	1.6	2.1	2.9	-1.7	-0.8	1.7	1.2	-1.7
Ever smoked	1.6	2.8	5.5	0.6	2.1	1.9	2.4	-0.2
Smoking Status	1.5	3.5	6.6	1.2	1.9	2.6	2.4	0.1
Stomach or abdominal pain in last month	1.5	1.8	3.5	-1.0	-1.9	-0.6	-1.8	-0.9
Falls in the last year	1.5	2.0	4.3	-0.4	-0.7	-1.5	-2.1	-1.7
Glaucoma (self-reported)	1.5	1.8	3.8	1.0	1.3	2.0	1.5	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	6.2	0.4	0.0	0.6	2.5	1.6
Leg fat mass (right)	1.5	5.6	22.3	-0.0	-1.0	0.9	-2.0	-4.7
Mother’s age at death	1.5	1.9	5.3	0.6	-1.8	-0.6	0.3	2.3
Illnesses of siblings	1.4	2.0	5.1	-0.4	0.5	0.8	2.0	2.2
Medication: Blood pressure	1.4	2.4	4.6	-2.1	-1.9	-0.6	-0.9	-1.6
Osteoarthritis (self-reported)	1.4	1.8	3.7	0.2	-1.0	-1.7	-1.9	-1.1
Medication: Aspirin	1.4	1.8	2.9	-1.7	-1.1	1.4	1.1	-1.3
Arm fat mass (left)	1.4	5.6	21.2	0.1	-1.3	1.3	-1.9	-4.6
Average weekly champagne plus white wine intake	1.4	1.9	5.5	-0.0	-1.8	-1.0	-2.3	-0.4
Major Depression (MDD)	1.3	1.6	4.8	2.2	0.1	1.6	0.7	-0.5
Cardiovascular Disease	1.3	4.3	7.4	-1.8	-2.3	-0.8	-2.1	-2.7
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	3.5	-0.1	1.1	1.5	1.9	-0.0
Past tobacco smoking	1.3	2.5	5.3	0.5	-1.3	-2.3	-2.2	0.0
Father’s age at death	1.3	1.7	6.1	0.2	-0.6	-2.5	-1.2	0.8
Number of live births	1.3	1.8	3.8	1.9	1.6	0.8	1.5	0.1
Hair/balding pattern: Pattern 4	1.3	3.1	6.5	0.8	1.6	0.6	2.5	2.3
Pulse wave reflection index	1.3	1.5	4.5	-1.1	-0.6	-2.1	-1.3	0.2
Exposure to tobacco smoke outside home	1.3	1.7	3.6	1.7	-0.3	-1.9	-0.7	1.4
Medication: Omeprazole	1.3	1.5	3.8	-1.6	-1.9	1.1	0.2	-0.2
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.3	0.1	1.2	-0.8	1.5	1.8
Commuting to job workplace: Public transport	1.3	1.6	3.2	-0.4	-1.5	-0.2	1.8	1.6
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	2.8	-1.6	-1.2	1.7	0.8	-0.4
Leg fat mass (left)	1.3	5.0	19.2	0.2	-1.2	1.0	-1.8	-4.4
Ulcerative Colitis	1.2	1.8	6.3	0.3	-2.5	1.4	0.0	-0.7
Townsend deprivation index at recruitment	1.2	1.7	4.6	-1.8	-0.5	0.5	-0.3	-2.1
Arm fat percentage (right)	1.2	4.9	18.7	-0.5	-1.1	1.1	-1.7	-4.3
Arm fat mass (right)	1.2	5.0	18.8	-0.2	-1.3	1.1	-1.8	-4.3
Leg fat percentage (right)	1.2	4.4	18.2	0.7	-0.4	1.2	-1.2	-4.3
Friendships satisfaction	1.2	1.5	2.9	1.4	1.0	1.7	1.2	0.3
Medication for cholesterol	1.2	1.8	2.8	1.1	1.5	0.7	1.6	1.7
Ever had prostate specific antigen (PSA) test	1.2	1.4	3.0	-1.6	-1.7	-1.2	-0.2	0.3
Crohns Disease (2017)	1.1	2.5	5.6	2.2	2.4	1.2	1.0	0.1
Prostate Cancer	1.1	1.5	4.0	1.2	0.0	0.9	1.1	2.0
Age at First Birth	1.1	1.6	4.5	1.3	-0.7	-1.0	0.3	2.1
Neuroticism (2016)	1.1	1.5	5.8	0.2	2.4	0.9	0.6	-0.8
Taking other prescription medications	1.1	1.7	3.4	0.6	1.2	1.8	1.8	0.4
Waist circumference	1.1	4.0	13.5	-0.5	-1.7	1.1	-1.5	-3.7
Number of incorrect matches in round	1.1	1.8	3.2	1.7	-0.5	-1.6	-1.8	-0.5
Alcohol usually taken with meals	1.1	1.8	4.2	-2.0	-1.8	-1.1	-0.5	0.2
Had menopause	1.1	1.4	2.2	-1.0	-1.4	-0.8	-0.9	-1.5
Weight	1.1	5.5	18.4	-0.9	-1.9	1.2	-1.8	-4.3
Alcohol intake versus 10 years previously	1.1	1.7	4.9	-0.7	1.4	2.2	0.7	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	5.2	1.2	2.3	0.8	0.1	-1.1
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	4.2	1.0	-0.1	0.6	-1.2	-2.0
Whole body fat mass	1.1	4.7	18.6	-0.4	-1.2	0.7	-1.7	-4.3
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	3.1	-0.3	1.6	-0.2	0.9	1.8
Arm fat percentage (left)	1.1	4.2	16.4	-0.1	-1.1	1.1	-1.4	-4.0
Ever had bowel cancer screening	1.1	1.3	4.1	-0.9	-0.1	-2.0	-1.2	-0.3
Commuting to job workplace: Walk	1.1	1.2	3.5	-1.9	-0.9	0.5	0.9	0.7
Wears glasses or contact lenses	1.1	1.3	3.7	0.2	1.5	-0.2	1.9	0.7
Eye problems/disorders: Glaucoma	1.1	1.4	2.4	0.4	1.5	1.6	1.4	-0.2
Leg fat percentage (left)	1.1	3.9	16.0	0.8	-0.7	1.1	-1.0	-4.0
LDL Cholesterol	1.0	1.5	3.1	-1.2	-1.8	-0.9	-1.6	0.0
Severe depression (siblings)	1.0	1.1	1.9	0.9	0.3	-1.1	-1.3	-1.4
Hayfever, allergic rhinitis or eczema	1.0	2.1	4.0	1.4	1.1	0.8	2.0	1.6
Body mass index (BMI)	1.0	4.4	16.1	0.1	-1.4	1.1	-1.7	-4.0
Trunk fat mass	1.0	4.3	17.5	-0.5	-1.0	0.7	-1.5	-4.2
Mouth/teeth dental problems	1.0	1.6	3.0	0.0	-1.3	-1.7	-1.6	0.8
Pain all over the body in last month	1.0	1.1	2.0	0.4	1.3	1.4	1.1	-0.7
Hip circumference	1.0	4.2	10.8	-0.0	-2.4	1.1	-1.7	-3.3
Happiness	1.0	1.2	3.5	1.1	-0.8	-0.6	-1.9	-0.5
Body fat percentage	1.0	3.9	16.8	-0.1	-0.8	0.7	-1.2	-4.1
Comparative body size at age 10	1.0	2.7	7.2	1.9	0.8	2.7	1.3	-0.5
Emphysema/chronic bronchitis	1.0	1.2	4.0	-2.0	-1.0	0.0	-0.3	-0.9
Angina (self-reported)	1.0	1.3	2.5	-1.4	0.8	1.2	-0.3	-1.6
Guilty feelings	1.0	1.5	4.0	1.0	2.0	1.2	1.0	0.2
Hearing aid user	1.0	1.1	3.5	0.1	-0.5	1.9	0.2	-1.3
Basal metabolic rate	1.0	5.5	15.4	-1.3	-2.0	1.0	-2.3	-3.9
Age started oral contraceptive pill	1.0	1.3	3.1	-0.8	-0.5	-1.8	-1.3	-0.7
Allergy or Eczema	0.9	2.4	4.2	1.6	0.6	1.0	2.0	2.0
Average weekly spirits intake	0.9	1.2	2.8	0.7	-0.9	-0.5	-1.2	-1.7
Angina	0.9	1.2	2.2	-1.1	1.1	1.3	-0.2	-1.5
Leg fat-free mass (left)	0.9	5.0	12.9	-1.8	-1.8	0.8	-2.2	-3.6
Leg predicted mass (left)	0.9	5.0	12.9	-1.8	-1.8	0.8	-2.2	-3.6
Qualifications: A levels/AS levels or equivalent	0.9	2.0	3.9	1.5	-1.4	1.2	0.8	2.0
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	3.8	-0.4	1.0	-1.9	-0.4	0.7
Exposure to tobacco smoke at home	0.9	1.0	3.5	-0.3	-0.9	-0.7	0.4	1.9
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	2.1	1.4	1.4	1.1	0.8	1.3
Gout (self-reported)	0.9	1.2	2.3	-1.5	-0.8	-1.1	-1.4	0.2
Medication: Ventolin 100micrograms inhaler	0.9	1.2	3.1	0.7	1.8	1.0	0.5	-1.1
Birth weight	0.9	1.9	4.8	1.3	-0.3	2.2	1.1	-1.5
Pulse rate, automated reading	0.9	2.9	10.8	-0.6	0.6	-3.3	-1.7	-0.5
Knee pain experienced in last month	0.9	1.4	2.7	1.2	0.1	0.4	-1.6	-1.6
Miserableness	0.9	1.6	4.6	-0.8	0.8	0.4	-1.3	-2.1
Ever taken oral contraceptive pill	0.9	1.0	2.2	1.0	0.9	1.5	0.9	0.3
Tinnitus: Yes, now most or all of the time	0.9	1.1	3.0	-0.6	-1.7	0.1	-1.0	-1.0
Medication: Atorvastatin	0.9	1.2	3.4	-0.4	-0.2	-0.9	-1.2	-1.8
Arm fat-free mass (left)	0.9	4.8	13.0	-0.8	-2.0	0.7	-2.4	-3.6
Arm predicted mass (left)	0.9	4.4	12.8	-0.5	-1.8	0.7	-2.3	-3.6
Worry (Nagel 2018)	0.8	1.7	5.3	0.5	1.6	-0.4	0.8	2.3
Breast Cancer	0.8	1.9	8.1	-0.1	-0.2	-1.1	0.6	2.8
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.5	0.5	0.4	-1.6	-1.2	0.3
Maternal smoking around birth	0.8	1.2	4.1	-2.0	1.0	-0.2	0.7	-0.4
Serious illness, injury or assault to yourself	0.8	0.9	3.3	0.0	-1.1	1.8	0.3	-0.0
Hearing difficulty/problems with background noise	0.8	1.3	3.9	-0.9	-2.0	1.3	0.4	0.1
Hair/balding pattern: Pattern 3	0.8	1.1	3.6	0.6	-0.5	-1.9	-1.2	-0.1
Medication: Lansoprazole	0.8	0.9	3.2	-1.8	-0.2	0.4	0.2	-1.1
Length of working week for main job	0.8	0.9	2.6	0.3	1.6	1.3	0.3	-0.2
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.1	0.3	1.3	0.8	1.4	-0.2
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.4	1.2	-0.8	0.3	0.5	1.5
Neck or shoulder pain in last month	0.8	1.1	3.0	-0.1	-0.3	-1.3	-1.7	-0.7
Number of full sisters	0.8	0.9	2.1	-1.4	0.7	0.6	0.2	-1.3
Whole body fat-free mass	0.8	4.4	11.2	-1.5	-1.9	1.0	-2.0	-3.3
Leg fat-free mass (right)	0.8	4.5	11.3	-1.7	-1.9	0.9	-2.0	-3.4
Long-standing illness, disability or infirmity	0.8	1.2	3.0	0.1	1.7	1.2	1.1	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.9	-0.9	-0.1	1.2	0.3	-1.4
Qualifications: nursing, teaching	0.8	1.2	3.5	1.9	0.4	1.2	0.9	0.3
Leg predicted mass (right)	0.8	4.5	11.2	-1.8	-1.9	0.9	-1.9	-3.3
Depressed Affect (Nagel 2018)	0.7	1.5	4.6	0.0	2.1	0.6	-0.2	-1.5
Ulcerative Colitis (UC)	0.7	1.3	2.6	-1.6	-1.1	1.5	0.3	-0.6
Reaction Time	0.7	1.3	2.2	-1.5	-0.2	-1.2	-1.3	-1.1
HDL Cholesterol	0.7	1.2	2.4	1.5	0.6	-1.6	0.2	1.1
Sensitivity / hurt feelings	0.7	1.2	3.0	0.7	-0.5	-1.1	-1.7	-1.0
Hearing difficulty/problems: Yes	0.7	1.0	3.3	-0.6	-1.8	0.0	-1.2	-0.3
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.8	-0.8	-1.4	-1.3	-0.5	0.5
Trunk fat percentage	0.7	3.0	13.1	-0.3	-0.6	0.4	-1.0	-3.6
Relative age voice broke	0.7	1.1	2.5	0.0	-0.9	0.9	1.1	1.6
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.0	-0.9	-0.6	-1.0	-0.8	-0.9
Qualifications: CSEs or equivalent	0.7	0.9	2.7	-1.0	-0.2	0.1	-0.9	-1.6
Financial difficulties in last 2 years	0.7	0.9	3.0	1.0	0.0	0.6	-0.3	-1.7
Loud music exposure frequency	0.7	0.7	1.3	1.1	0.5	1.1	0.8	0.4
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	4.4	2.1	0.1	0.7	0.7	-0.6
Arm fat-free mass (right)	0.7	3.5	9.5	-0.4	-1.8	0.7	-2.0	-3.1
Pulse wave peak to peak time	0.7	0.8	2.3	-0.2	-0.8	1.5	0.9	0.5
Qualifications: College or University degree	0.7	2.2	4.6	1.1	-0.3	2.1	2.1	0.7
Medication: Ibuprofen	0.7	0.9	3.1	-0.1	0.9	-1.7	0.1	0.6
Suffer from ‘nerves’	0.7	1.1	2.5	0.3	1.6	-0.3	0.5	1.5
Overall health rating	0.7	1.5	3.2	-1.0	-1.4	-0.8	-1.8	-0.5
Leg pain on walking	0.7	0.8	1.5	-1.2	-0.7	0.2	-0.8	-1.2
Whole body water mass	0.7	4.1	11.4	-1.2	-1.7	1.1	-1.9	-3.4
Diastolic blood pressure, automated reading	0.7	2.2	7.8	-0.6	-2.8	-1.1	-1.0	-0.7
Commuting to job workplace: Cycle	0.7	0.8	2.7	-1.0	-1.6	0.2	-0.6	0.1
Heart disease (siblings)	0.7	0.9	3.7	0.2	1.9	-0.3	0.2	-0.7
Alcohol drinker status: Previous	0.7	0.8	1.8	0.3	0.6	0.4	1.4	1.2
Verbal and Numeric Reasoning (VNR)	0.6	1.5	5.6	-0.4	-0.0	2.4	1.2	-0.7
Primary Biliary Cirrhosis	0.6	0.9	1.4	1.2	-0.1	1.1	1.2	-0.7
Blood Eosinophil Count	0.6	5.0	15.3	3.9	1.5	1.6	-1.4	-1.7
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.5	1.6	0.8	0.8	1.2	-0.1
Vitamin and mineral supplements	0.6	0.7	3.4	-0.3	1.9	0.1	0.4	-0.3
Average weekly fortified wine intake	0.6	0.7	1.0	-1.0	-0.9	-0.8	-0.9	0.5
Fed-up feelings	0.6	1.0	3.2	-0.4	1.2	0.3	-0.5	-1.8
Trunk fat-free mass	0.6	3.7	9.7	-1.2	-1.7	1.1	-1.8	-3.1
Time employed in main current job	0.6	0.7	1.8	1.0	0.5	0.5	0.5	1.3
Medication: Cholesterol lowering	0.6	0.9	3.4	-0.7	-0.6	0.4	0.0	-1.8
Trunk predicted mass	0.6	3.6	9.1	-1.2	-1.7	1.1	-1.7	-3.0
Blood clot in the leg (DVT)	0.6	0.7	2.8	-1.7	-0.5	0.3	-0.2	-0.8
Medication: Paracetamol	0.6	1.0	1.6	-1.3	0.9	-1.3	-0.0	0.9
Shortness of breath walking on level ground	0.6	0.7	1.2	-0.9	-1.1	-0.0	-0.7	-1.1
Arm predicted mass (right)	0.6	3.2	8.6	-0.3	-1.7	0.6	-2.0	-2.9
Had major operations	0.6	0.7	1.2	-0.5	-0.9	-1.1	-1.1	0.1
Family relationship satisfaction	0.6	0.8	2.7	0.9	-0.0	1.6	-0.4	-0.3
Illnesses of siblings: Diabetes	0.6	0.7	1.6	0.4	1.2	0.3	1.2	0.4
Average weekly red wine intake	0.6	0.9	1.3	-1.2	-1.0	-1.1	-1.0	0.5
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.4	0.6	1.6	-0.2	0.0	0.7
Loneliness, isolation	0.6	0.8	1.3	0.3	1.1	-0.7	-1.0	-1.0
Eye problems/disorders: Cataract	0.6	0.7	2.4	-0.5	-0.9	-0.4	0.2	1.6
Breast cancer (self-reported)	0.6	0.7	1.3	1.0	0.9	1.1	0.6	0.4
Average weekly beer plus cider intake	0.6	0.8	1.3	-0.8	0.7	0.8	-0.9	-1.1
Unable to work because of sickness or disability	0.6	0.8	2.5	-0.4	1.6	-0.8	0.5	0.6
Myopia	0.6	0.9	1.9	-0.7	-0.1	1.4	1.0	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.8	-1.7	-0.6	0.1	-0.2	-0.7
Pack years of smoking	0.6	1.0	2.2	-1.5	-0.5	1.1	-0.2	-1.1
Neuroticism (Nagel 2018)	0.5	1.2	5.9	0.3	2.4	-0.4	0.1	0.1
Irritable Bowel Disease (IBD)	0.5	1.3	3.5	0.8	1.0	1.9	0.9	-0.6
Coronary Artery Disease (CAD)	0.5	0.6	1.4	1.2	-0.3	-0.6	-0.8	-0.8
HbA1C	0.5	0.6	1.5	1.2	0.7	0.0	0.8	0.4
BMI	0.5	2.8	11.1	0.5	-0.8	0.7	-1.1	-3.3
Respiratory disease	0.5	1.0	2.3	0.4	1.3	-0.1	1.0	1.5
Neuroticism	0.5	1.2	2.6	-0.4	1.3	1.6	1.2	0.4
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.4	-0.1	0.4	1.2	1.1	-0.3
Medication for hormone replacement therapy	0.5	0.6	1.7	-0.8	-0.8	0.2	-0.3	-1.3
Supplements: Zinc	0.5	0.5	1.7	-0.6	-1.3	-0.0	-0.6	0.4
Pack years adult smoking proportion	0.5	0.8	1.6	-1.0	-0.4	1.3	-0.4	-1.0
High blood pressure (mother)	0.5	0.6	1.9	0.6	-1.4	-0.3	-0.6	0.7
Impedance of leg (left)	0.5	2.5	5.2	1.3	1.5	-0.7	1.7	2.3
Medication: Simvastatin	0.5	0.7	2.5	0.0	0.3	1.0	1.6	-0.0
Noisy workplace	0.5	0.6	1.9	-1.4	0.4	-1.1	-0.1	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.3	-1.1	-0.4	0.2	-0.7	-0.8
Prospective memory result	0.5	0.6	1.9	-0.6	1.4	-0.4	0.8	-0.1
Pulse wave Arterial Stiffness index	0.5	0.6	1.9	0.2	0.8	-1.4	-0.7	-0.4
Breastfed as a baby	0.5	0.6	1.7	-0.4	-1.3	-0.8	-0.3	0.7
Medication: Amlodipine	0.5	0.7	2.0	-1.2	0.3	-0.2	-0.3	-1.4
Number of full brothers	0.5	0.6	1.3	0.7	-0.0	0.5	-1.1	-0.9
Medication for pain relief, constipation, heartburn	0.5	0.9	3.5	1.9	-0.6	0.4	-0.7	0.3
Migraine (self-reported)	0.5	0.6	2.1	-0.3	-0.0	0.5	0.7	1.4
Medication: Seretide 50 evohaler	0.5	0.6	1.5	-0.1	-0.9	-0.2	-0.6	-1.2
Mean time to correctly identify matches	0.5	1.0	2.5	-1.6	-0.3	-0.9	-0.7	-1.0
Heart disease (mother)	0.5	0.7	3.0	-1.7	0.5	-0.1	0.2	-0.2
Mood swings	0.5	0.9	2.9	-0.2	1.7	1.1	0.1	-0.4
Number of self-reported non-cancer illnesses	0.5	0.8	2.5	-1.2	-0.0	-0.5	-0.1	-1.6
Medication: Paracetamol	0.5	0.7	1.4	-0.9	0.6	-1.0	0.5	1.2
Irritability	0.5	0.8	2.5	-0.6	0.3	-0.6	-1.6	-0.8
Basal cell carcinoma (self-reported)	0.5	0.6	2.0	-0.3	0.8	0.3	1.4	0.5
Bipolar Disorder (2018)	0.4	0.7	2.0	-1.0	-0.1	-1.4	-0.4	0.5
Depression (Nagel 2018)	0.4	0.6	1.7	0.9	1.3	-0.0	0.4	0.4
Intelligence (Savage-Jansen 2018)	0.4	1.1	3.0	-0.9	-0.8	1.7	1.0	-0.2
Bipolar Disorder (2011)	0.4	0.4	1.5	-0.6	-0.1	-0.4	-0.3	-1.2
Height	0.4	7.2	15.1	-3.9	-3.4	0.2	-1.7	-2.5
Systolic Blood Pressure	0.4	2.0	7.5	-1.4	-2.7	0.1	-0.7	0.2
Number of treatments/medications taken	0.4	0.7	2.2	-0.9	0.1	0.2	0.5	-1.5
Ever had hysterectomy (womb removed)	0.4	0.4	0.9	-0.7	0.4	-0.9	0.6	-0.7
Diabetes (mother)	0.4	0.4	1.3	-0.4	1.1	0.3	0.7	-0.4
Impedance of leg (right)	0.4	2.2	4.4	1.0	1.8	-0.7	1.3	2.1
Current tobacco smoking	0.4	0.7	2.1	1.4	1.1	-0.2	0.3	0.1
Chronic bronchitis/emphysema (father)	0.4	0.4	1.0	1.0	-0.3	-0.5	-0.9	0.0
Nervous feelings	0.4	0.7	1.1	0.4	1.0	-1.0	-0.8	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.6	0.5	0.9	0.4	0.8	1.3
Allergy	0.4	0.9	2.3	0.5	0.1	-0.4	-1.4	-1.5
Fluid intelligence score	0.4	0.8	2.2	-0.3	-0.5	1.5	1.0	0.4
Impedance of arm (right)	0.4	2.0	3.7	-1.3	1.3	-0.4	1.7	1.9
Mouth/teeth dental problems: Dentures	0.4	0.7	1.1	-0.9	1.0	0.9	1.1	0.2
Lung cancer (father)	0.4	0.4	1.3	-0.7	-0.3	-0.1	0.5	1.1
Illnesses of mother	0.4	0.5	1.4	-0.4	0.5	1.2	0.8	-0.5
Impedance of arm (left)	0.4	1.9	4.8	-0.7	0.9	-0.5	1.7	2.2
Tense / ‘highly strung’	0.4	0.7	2.0	-0.5	0.3	-0.9	-0.7	1.4
Peak expiratory flow (PEF)	0.4	0.9	2.0	0.9	0.5	1.4	0.7	1.0
Number of children fathered	0.4	0.4	0.8	0.9	0.7	0.8	0.5	0.1
Comparative height size at age 10	0.4	2.3	5.7	-2.4	-1.5	0.4	-0.8	-1.6
Chest pain or discomfort	0.4	0.6	1.6	0.2	0.3	1.2	1.3	-0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.3	1.2	1.1	0.1	-0.1	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.8	-0.3	-0.8	0.6	0.6	-0.9
Mineral and other dietary supplements	0.4	0.5	0.9	0.9	-0.1	0.8	0.6	0.9
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.2	0.3	0.8	-1.1	-0.6	-0.6
Medication: Bendroflumethiazide	0.4	0.6	1.5	-1.1	0.2	-0.3	1.2	0.1
Illnesses of father: High blood pressure	0.4	0.5	1.6	-0.5	-1.3	0.4	-0.4	0.3
Risk taking	0.4	0.6	1.5	1.2	0.3	1.1	0.5	0.4
Impedance of whole body	0.4	2.1	5.6	0.2	1.2	-1.0	1.5	2.4
Schizophrenia vs Biploar Disorder	0.3	0.3	0.9	0.2	-0.3	0.6	-0.6	-0.9
Ovarian Cancer	0.3	0.4	0.8	-0.4	0.6	-0.4	0.9	0.9
Mean Putamen Volume	0.3	0.3	1.0	0.6	0.1	-0.1	-1.0	0.6
Fasting Glucose	0.3	0.4	1.1	-0.6	0.5	-1.0	-0.4	0.5
Blood Platelet Count	0.3	3.9	14.4	-1.4	0.2	0.8	-1.5	-3.8
Heel T-Score	0.3	2.6	6.4	-2.5	-1.5	-1.1	-1.1	-1.3
Chronotype (morning person)	0.3	0.6	1.8	-1.3	-0.1	-0.1	0.6	1.0
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.9	0.8	0.7	0.1	0.1	1.0
Medication: Co-codamol	0.3	0.3	1.0	0.2	-1.0	-0.5	-0.7	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.5	1.6	-0.0	1.3	0.2	0.4	0.7
Age when periods started (menarche)	0.3	0.6	1.9	-0.4	0.7	-1.4	0.5	0.6
Multivitamins +/- minerals	0.3	0.4	1.7	0.1	-1.3	-0.1	-0.4	-0.2
Had other major operations	0.3	0.4	0.8	0.6	0.9	-0.6	0.7	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.1	-0.4	-0.9	1.1	0.5	0.8
Qualifications: None of the above	0.3	0.7	1.9	-1.1	0.7	-0.0	0.1	-1.4
Worrier / anxious feelings	0.3	0.6	1.4	0.6	0.3	-1.2	-1.0	0.3
Worry too long after embarrassment	0.3	0.5	1.4	0.4	0.7	-1.2	0.5	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.9	0.0	0.9	0.3	0.5	0.6
Wheeze or whistling in the chest in last year	0.3	0.5	1.3	-1.1	-0.4	0.8	0.1	-0.3
Eye problems/disorders: None of the above	0.3	0.3	0.5	0.6	0.6	-0.7	-0.5	-0.3
Supplements: Vitamin C	0.3	0.4	0.5	0.6	0.6	0.7	0.7	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.4	-0.5	0.5	0.1	-0.6	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.6	-0.4	-0.8	-0.3	-0.8	-0.7
Back pain experienced in last month	0.3	0.4	1.3	0.7	0.4	0.4	-0.2	-1.1
Medication: Gliclazide	0.3	0.4	1.0	-0.3	-0.3	-1.0	-0.7	-0.5
Alcohol drinker status: Never	0.3	0.4	0.7	0.1	0.7	-0.4	0.7	0.9
Bipolar Disorder or Schizophrenia	0.2	0.4	1.1	-0.2	-0.3	-1.1	-0.8	0.4
Alzheimer’s Disease (in father)	0.2	0.2	1.1	0.0	-0.2	-1.1	-0.1	0.2
Body Mass Index (BMI) (2010)	0.2	0.2	0.8	0.9	0.0	0.1	-0.2	0.4
Lupus	0.2	0.4	0.8	-0.5	-0.4	0.9	0.2	-0.8
Lung FEV1/FVC ratio	0.2	1.0	3.1	-0.5	-0.2	1.2	1.8	-0.4
Lung FVC	0.2	0.8	2.7	1.0	1.6	0.3	0.7	-0.1
Hair Pigment	0.2	6.8	21.0	2.1	4.6	1.3	2.5	-0.7
Hand grip strength (left)	0.2	0.6	1.6	-0.9	-0.2	1.3	0.1	-0.6
Relative age of first facial hair	0.2	0.4	0.8	-0.9	-0.6	0.7	0.4	-0.1
Systolic blood pressure, automated reading	0.2	0.7	2.4	-0.6	-1.6	-0.1	-0.2	-0.7
Medication: Metformin	0.2	0.3	0.5	0.7	0.6	-0.1	0.6	-0.2
Hand grip strength (right)	0.2	0.6	1.9	-0.4	0.4	1.4	0.8	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.1	-0.9	-1.0	-0.1	-0.6	0.2
Supplements: Glucosamine	0.2	0.3	0.7	-0.1	-0.3	-0.0	-0.7	-0.8
Sitting height	0.2	1.5	2.7	-1.2	-0.6	1.4	-0.9	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.3	0.7	-0.0	1.1	-0.2	-0.0
Standing height	0.2	1.7	5.8	-2.4	-1.3	0.4	-0.4	-0.9
Headache pain in last month	0.2	0.3	0.5	-0.6	-0.7	0.5	0.6	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	-0.8	-0.5	0.1	0.2	0.1
Age at first live birth	0.2	0.3	0.6	0.4	0.8	-0.7	-0.2	-0.0
Alcohol intake frequency.	0.2	0.4	1.3	-0.3	0.6	1.2	0.6	0.0
Age at last live birth	0.2	0.3	0.6	0.7	0.7	0.0	0.3	-0.4
Diabetes diagnosed by doctor	0.2	0.3	0.5	0.5	0.4	-0.6	0.7	0.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.9	-0.4	0.4	0.1	-0.3	-1.0
Smoking status: Current	0.2	0.3	0.8	0.9	0.8	-0.2	0.1	-0.1
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.0	-0.2	-1.0	-0.2	-0.2	0.6
High cholesterol (Self-reported)	0.2	0.4	1.1	0.5	-0.1	0.2	0.8	-1.0
Number of operations (self-reported)	0.2	0.3	0.8	-0.5	0.9	-0.5	0.0	-0.5
Schizophrenia (2018)	0.1	0.2	0.5	0.6	-0.3	-0.2	-0.7	0.1
Rheumatoid Arthritis	0.1	0.2	0.4	0.6	-0.2	0.6	-0.3	-0.2
Schizophrenia (2014)	0.1	0.3	0.7	0.0	-0.6	-0.1	-0.8	-0.7
Triglycerides	0.1	0.2	0.4	-0.7	-0.6	0.6	-0.0	-0.3
Blood Red Count	0.1	1.2	2.1	-0.9	1.1	-0.4	-1.2	-1.4
Waist Hip Ratio (WHR)	0.1	0.5	1.2	-0.6	0.7	1.1	0.5	-0.4
Tanning	0.1	1.0	2.0	0.5	1.4	1.0	1.4	0.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.4	-0.0	-0.5	0.1	-0.5	-0.6
Diabetes (father)	0.1	0.1	0.2	-0.2	0.3	-0.0	-0.4	0.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	0.3	0.2	-0.0	-0.2	-0.4
Forced vital capacity (FVC)	0.1	0.3	1.0	-0.4	0.6	-0.3	-1.0	-0.4
Heart attack	0.1	0.1	0.3	-0.1	0.5	-0.4	0.1	0.4
Diabetes (self-reported)	0.1	0.2	0.4	-0.1	-0.1	-0.5	0.6	0.2
Neuroticism score	0.1	0.2	0.8	-0.0	0.9	0.2	-0.5	-0.1
Depression (self-reported)	0.1	0.1	0.2	0.4	-0.5	-0.4	0.1	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.7	-0.8	-0.0	0.5	0.2	0.1
Birth weight of first child	0.1	0.2	0.6	0.1	-0.5	0.5	-0.1	-0.8
Forced vital capacity (FVC), Best measure	0.1	0.4	0.9	-1.0	-0.3	0.4	-0.6	-0.7
Health satisfaction	0.1	0.1	0.3	0.6	-0.4	0.2	-0.2	-0.4
Osteoporosis (self-reported)	0.1	0.2	0.5	0.0	0.1	-0.2	0.4	0.7
Illnesses of father: None of the above (group 1)	0.1	0.2	0.6	0.1	-0.4	0.8	-0.0	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.4	-0.1	-0.1	0.6	0.3	-0.3
Cholesterol lowering medication	0.1	0.1	0.2	-0.4	-0.1	0.1	0.2	-0.5
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.3	-0.0	0.6	-0.2	-0.4	0.4
Asthma	0.0	0.0	0.1	0.1	-0.2	0.1	-0.2	0.1
Asthma (self-reported)	0.0	0.0	0.1	0.3	0.0	0.3	0.1	0.2
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	0.1	0.2	-0.0	-0.1	0.1

Hub : Genes

LEPRE1

Models

Trait associations