Hub : Genes

PPIH

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue (Female)	0.0685	0.0577	0.14000	-0.007	NA	-0.008	NA	-0.006	5.9e-01	NA	6.6e-01	NA	5.5e-01
2	GTEx	Testis	0.5400	0.0750	0.00000	0.622	NA	0.582	NA	0.596	1.4e-34	NA	3.2e-31	NA	2.6e-32
3	YFS	Blood	0.0118	0.0062	0.00690	0.010	0.004	0.010	0.005	0.012	2.8e-04	0.0120	2.9e-04	0.0053	6.8e-05
4	TCGA	Prostate Adenocarcinoma	0.0449	0.0275	0.00072	0.015	0.015	0.021	NA	0.013	8.9e-03	0.0089	2.3e-03	NA	1.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.4	0.6	1.4	-0.0	0.1	1.0	1.2
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	0.4	0.5	0.2	-0.1
Depressed Affect (Nagel 2018)	0.6	1.3	3.1	0.2	1.8	-1.2	-0.7
Depression (Nagel 2018)	1.1	1.6	3.8	0.5	1.2	-2.0	-0.9
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.1	-1.4	-1.4	1.1	0.2
Neuroticism (Nagel 2018)	1.8	4.3	8.9	1.7	2.1	-3.0	-1.0
Schizophrenia (2018)	0.2	0.5	1.1	0.5	0.6	-0.5	-1.1
Schizophrenia vs Biploar Disorder	0.2	0.3	0.9	-0.2	0.1	-0.4	-0.9
Worry (Nagel 2018)	4.0	8.3	15.4	3.1	1.3	-3.9	-2.6
Alzheimer’s Disease (in mother)	0.2	0.2	0.6	0.2	-0.2	0.5	0.8
Alzheimer’s Disease (in father)	0.6	0.7	2.3	-0.3	0.3	0.4	1.5
Alzheimer’s Disease (including proxy)	0.2	0.2	0.5	0.2	0.6	-0.2	0.7
Crohns Disease (2017)	2.7	5.9	9.9	1.7	3.1	-2.4	-2.3
Irritable Bowel Disease (IBD)	1.6	3.8	6.1	1.3	2.5	-1.8	-2.0
Ulcerative Colitis (UC)	0.0	0.1	0.1	0.2	0.1	0.3	-0.3
Major Depression (MDD)	0.1	0.2	0.3	-0.2	0.5	0.2	0.5
Reaction Time	0.5	1.0	1.9	-0.7	-0.1	1.2	1.4
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.9	-0.1	-0.1	-0.6	-1.7
Breast Cancer	0.2	0.6	1.2	0.6	-1.1	-0.7	-0.5
Ovarian Cancer	1.5	2.0	2.5	1.5	1.0	-1.5	-1.6
Prostate Cancer	0.8	1.1	2.7	1.6	0.2	-1.3	-0.2
Age at First Birth	0.3	0.4	0.7	-0.3	-0.9	0.5	0.6
Bipolar Disorder (2011)	0.3	0.3	0.8	-0.9	0.4	0.3	0.3
Body Mass Index (BMI) (2010)	1.6	2.2	3.9	1.4	0.9	-2.0	-1.6
Coronary Artery Disease (CAD)	0.1	0.1	0.2	-0.3	0.3	0.5	-0.0
Crohns Disease (2012)	3.8	6.2	9.7	2.1	3.1	-2.7	-1.8
Mean Putamen Volume	0.2	0.2	0.3	0.5	0.6	-0.5	-0.0
Fasting Glucose	1.8	2.2	3.1	1.6	0.7	-1.6	-1.8
HbA1C	0.2	0.2	0.6	0.1	-0.1	-0.1	0.8
HDL Cholesterol	0.1	0.1	0.3	0.3	-0.2	-0.3	0.5
LDL Cholesterol	0.8	1.2	1.9	-1.1	-1.4	1.3	0.2
Lupus	1.2	1.8	2.6	-1.6	-1.4	1.1	1.2
Neuroticism (2016)	1.1	1.6	3.0	0.9	1.7	-1.4	-0.8
Primary Biliary Cirrhosis	0.6	0.9	1.7	-1.1	-0.0	0.8	1.3
Rheumatoid Arthritis	0.1	0.1	0.4	-0.1	-0.2	-0.6	-0.2
Schizophrenia (2014)	0.1	0.3	0.8	-0.0	0.9	-0.3	-0.6
Triglycerides	0.1	0.1	0.2	0.4	-0.3	-0.2	-0.4
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.2	1.1	0.8	-0.6	0.1
Ulcerative Colitis	0.7	1.0	1.8	-1.3	-0.9	0.9	0.7
Blood Eosinophil Count	0.5	3.8	10.9	1.4	3.3	-1.1	-1.0
Blood Platelet Count	0.4	5.1	8.0	-2.5	-0.1	2.8	2.5
Blood Red Count	0.0	0.1	0.3	0.1	0.5	0.0	-0.5
Blood White Count	2.8	20.9	30.8	3.1	4.7	-5.5	-4.5
Heel T-Score	0.0	0.1	0.4	-0.4	-0.6	0.2	-0.1
BMI	0.5	2.9	4.1	-1.9	-0.5	2.0	1.9
Height	0.5	10.6	15.8	-4.0	-3.4	3.9	0.3
Waist Hip Ratio (WHR)	0.0	0.1	0.2	-0.5	0.5	0.2	-0.3
Systolic Blood Pressure	0.4	1.9	3.4	-1.1	-1.8	1.6	-0.7
Smoking Status	0.4	0.9	2.5	-0.6	1.6	-0.6	0.5
Allergy or Eczema	0.2	0.5	1.7	0.6	0.0	-1.3	-0.4
Cardiovascular Disease	2.4	7.9	10.2	-3.2	-2.3	3.1	2.6
Hypothyroidism (self reported)	3.1	7.2	13.8	2.5	3.7	-2.1	-2.1
Respiratory disease	0.9	2.1	4.5	2.1	1.3	-1.3	-0.4
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	0.3	0.9	-0.8	0.1
Lung FEV1/FVC ratio	0.0	0.1	0.2	0.0	0.0	-0.2	-0.5
Lung FVC	0.7	3.3	4.0	1.9	1.7	-1.7	-2.0
Neuroticism	0.9	2.2	5.1	1.1	0.8	-2.3	-1.4
Chronotype (morning person)	0.1	0.2	0.4	0.2	-0.6	-0.2	0.4
Hair Pigment	0.2	4.9	14.6	1.9	3.8	-1.0	-0.3
Tanning	0.0	0.1	0.3	-0.2	0.4	-0.1	0.6
Hand grip strength (left)	0.1	0.3	0.8	-0.3	0.5	0.4	-0.9
Number of treatments/medications taken	0.3	0.6	1.8	-1.4	-0.1	0.1	0.6
Average weekly spirits intake	2.0	2.5	4.5	-1.6	-0.4	1.7	2.1
Sensitivity / hurt feelings	0.0	0.1	0.2	-0.4	-0.1	-0.4	0.0
Frequency of depressed mood in last 2 weeks	0.8	1.1	3.0	0.5	0.5	-1.7	-1.0
Hearing difficulty/problems: Yes	0.3	0.4	0.8	-0.4	-0.9	0.5	-0.6
Relative age of first facial hair	0.1	0.2	0.6	-0.1	-0.1	0.1	-0.8
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.4	-0.6	-0.3	-0.3	0.3
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.4	0.4	-1.2	-0.0	-0.2
Ever had hysterectomy (womb removed)	0.4	0.4	0.8	0.4	0.8	-0.9	-0.1
Systolic blood pressure, automated reading	0.8	2.3	4.1	-1.6	-1.4	2.0	0.6
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.4	0.3	0.8	-0.9	-1.2
Angina	0.5	0.7	1.1	-1.0	0.6	0.9	0.7
Medication for hormone replacement therapy	1.0	1.1	2.7	-0.2	-1.0	1.6	0.8
Vitamin and mineral supplements	2.0	2.7	4.9	1.7	2.2	-1.1	-1.2
Supplements: Zinc	0.5	0.5	0.7	-0.3	-0.8	0.9	0.7
Medication: Co-codamol	2.4	2.8	4.0	-1.4	-1.7	2.0	1.6
Medication: Metformin	0.2	0.3	0.7	0.7	0.8	-0.2	-0.2
Diabetes (father)	0.2	0.3	0.8	0.3	0.9	-0.5	-0.2
Diabetes (mother)	0.2	0.2	0.6	0.3	0.8	-0.3	-0.3
Severe depression (siblings)	0.4	0.4	1.1	-1.0	0.5	-0.4	0.4
Pack years adult smoking proportion	0.0	0.1	0.1	-0.4	-0.1	0.1	0.3
Impedance of leg (right)	0.4	2.1	3.5	1.5	1.4	-1.9	-0.8
Leg fat-free mass (left)	0.6	3.1	7.6	-2.8	-1.0	1.9	-0.1
Trunk fat percentage	2.0	7.9	13.2	-3.6	-1.2	3.0	2.8
Hand grip strength (right)	0.6	1.7	4.7	1.0	1.0	-0.3	-2.2
Townsend deprivation index at recruitment	2.0	2.8	3.8	-1.9	-1.2	1.8	1.7
Current tobacco smoking	1.3	2.1	4.3	0.6	1.6	-2.1	-1.1
Average weekly fortified wine intake	0.2	0.3	0.9	0.1	-0.4	-0.2	-0.9
Maternal smoking around birth	1.7	2.5	5.8	-1.4	-0.8	1.2	2.4
Fed-up feelings	0.2	0.3	0.7	0.4	0.9	-0.1	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.8	0.4	0.9	-0.6	-0.8
Relative age voice broke	1.6	2.5	6.7	1.6	-0.4	-0.7	-2.6
Taking other prescription medications	0.2	0.3	0.8	0.1	0.9	-0.6	0.5
Age when periods started (menarche)	0.5	1.1	2.2	-1.5	-0.4	0.8	1.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	0.5	0.3	0.3	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.4	0.5	-1.2	0.2	-0.4
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	-0.5	0.8	0.1	-0.3
Qualifications: CSEs or equivalent	3.0	4.0	7.9	-1.5	-1.0	2.2	2.8
Serious illness, injury or assault to yourself	0.6	0.8	2.4	0.1	-0.8	-0.3	-1.5
High blood pressure	4.1	11.3	16.0	-3.5	-3.2	4.0	2.6
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.6	0.3	0.4	-1.2	-0.3
Multivitamins +/- minerals	0.7	0.9	1.9	-1.4	-1.0	0.7	0.3
Stomach or abdominal pain in last month	3.5	4.4	6.6	-2.6	-2.6	1.5	1.4
Supplements: Glucosamine	1.1	1.4	2.0	-1.1	-0.7	1.3	1.4
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.7	-0.8	-0.0	0.4	0.7
Medication: Atenolol	3.0	3.8	9.6	-3.1	-0.7	1.9	1.3
Medication: Levothyroxine sodium	1.0	1.7	3.7	0.9	1.9	-1.0	-1.0
Sitting height	0.2	1.6	5.4	0.2	0.5	-0.8	-2.3
Chronic bronchitis/emphysema (father)	0.6	0.7	1.3	0.5	0.9	-1.1	-0.6
High blood pressure (mother)	0.2	0.3	0.5	-0.7	-0.7	0.3	0.1
Body mass index (BMI)	1.2	5.1	8.6	-2.9	-1.1	2.6	1.9
Impedance of leg (left)	0.2	1.2	2.2	1.5	1.1	-1.2	-0.0
Leg predicted mass (left)	0.6	3.1	7.4	-2.7	-1.1	1.9	-0.1
Trunk fat mass	1.8	7.8	14.5	-3.8	-1.2	3.2	2.3
Waist circumference	1.9	7.1	13.5	-3.7	-1.5	3.1	1.6
Number of incorrect matches in round	0.3	0.4	1.3	0.2	0.1	0.6	1.1
Past tobacco smoking	0.6	1.0	1.8	1.2	-0.1	-0.9	-1.3
Alcohol usually taken with meals	0.7	1.2	3.0	-0.5	-1.7	0.9	0.9
Nervous feelings	1.6	3.0	7.9	1.1	0.7	-2.8	-1.6
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	2.0	0.7	0.7	-1.4	-1.1
Hearing difficulty/problems with background noise	0.9	1.4	3.2	-1.3	-1.8	0.7	0.4
Hair/balding pattern: Pattern 2	5.5	7.0	10.5	-2.1	-2.7	3.2	2.4
Had menopause	2.6	3.3	5.6	-2.4	-1.3	1.5	1.9
Had other major operations	0.9	1.0	2.7	0.6	-0.1	-1.1	-1.6
Forced vital capacity (FVC)	0.5	1.9	4.2	1.3	0.9	-1.0	-2.0
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.2	0.5	-0.8	-0.6	-1.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.7	-0.3	1.3	-0.1	1.2
Qualifications: None of the above	1.2	2.6	4.5	-1.2	-0.1	2.1	2.1
Financial difficulties in last 2 years	0.9	1.3	2.3	-1.0	0.0	1.3	1.5
Mouth/teeth dental problems	0.9	1.4	4.7	-0.1	-2.2	0.9	0.3
Heart attack	1.0	1.3	4.4	-0.9	-0.1	0.4	2.1
Allergy	0.2	0.4	0.9	0.4	0.6	-0.2	-1.0
Pain all over the body in last month	0.7	0.8	1.7	0.7	1.3	-0.9	-0.2
Diabetes (self-reported)	0.1	0.1	0.2	-0.5	-0.4	-0.1	0.1
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.2	1.1	-0.4	-0.4	-0.2
Medication: Ramipril	0.1	0.1	0.3	-0.0	-0.5	0.2	-0.3
Medication: Simvastatin	0.3	0.4	0.9	-0.9	-0.3	0.1	0.7
Fluid intelligence score	0.3	0.6	1.7	0.2	-0.6	-0.5	-1.3
Illnesses of siblings	0.4	0.6	1.7	1.3	0.1	-0.8	-0.3
Neuroticism score	1.2	2.4	4.6	1.0	0.8	-2.1	-1.8
Weight	1.3	6.4	12.5	-3.5	-1.4	3.1	1.4
Impedance of arm (right)	0.1	0.3	0.9	0.4	0.2	-0.9	-0.0
Arm fat percentage (right)	1.9	7.6	13.2	-3.6	-1.2	3.1	2.5
Trunk fat-free mass	0.3	1.9	3.9	-2.0	-0.7	1.7	-0.7
Hip circumference	1.1	4.7	8.9	-3.0	-1.8	2.4	0.9
Time employed in main current job	1.7	1.9	2.2	1.3	1.5	-1.3	-1.4
Alcohol intake versus 10 years previously	0.7	1.1	1.8	1.3	1.2	-0.8	-0.6
Father’s age at death	0.1	0.2	0.6	-0.2	-0.8	-0.2	-0.1
Worrier / anxious feelings	1.1	2.1	4.5	1.1	0.6	-2.1	-1.6
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	4.8	0.7	0.9	-1.1	-2.2
Falls in the last year	0.4	0.5	1.0	-1.0	0.2	0.8	0.7
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	-0.1	-0.5	-0.3	-0.3
Number of live births	1.5	2.1	4.8	2.2	1.5	-0.7	-1.0
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	4.9	1.7	1.0	-1.6	-2.2
Pulse rate	0.9	1.6	5.0	1.0	2.2	-0.5	0.1
Happiness	0.4	0.5	1.2	-0.7	-0.1	-1.1	-0.4
Noisy workplace	0.3	0.4	0.9	0.2	-0.5	0.5	-0.9
Qualifications: A levels/AS levels or equivalent	1.3	2.9	6.7	1.4	0.2	-1.7	-2.6
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	2.8	-0.1	0.6	-1.3	-1.7
Mouth/teeth dental problems: Dentures	0.2	0.4	1.0	0.5	1.0	-0.5	-0.1
Asthma	0.1	0.2	0.3	0.5	0.5	-0.2	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.4	1.6	-0.4	0.0	0.1	1.3
Medication: Cholesterol lowering	3.6	5.6	9.1	-3.0	-1.4	2.4	2.3
Depression (self-reported)	0.3	0.4	0.9	-0.9	-0.3	-0.6	0.4
Medication: Lansoprazole	0.4	0.5	1.6	-1.3	0.4	0.4	0.1
Prospective memory result	0.1	0.2	0.4	0.5	0.6	-0.2	-0.0
Lung cancer (father)	0.9	1.1	2.3	0.8	-0.3	-1.1	-1.5
Illnesses of mother	0.2	0.3	0.4	0.4	0.3	-0.6	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	4.8	1.0	0.1	-1.0	-2.2
Pulse wave Arterial Stiffness index	0.7	0.9	2.4	0.9	0.4	-0.3	-1.6
Impedance of arm (left)	0.0	0.2	0.5	0.2	-0.1	-0.7	0.3
Arm fat mass (right)	1.5	6.0	11.6	-3.4	-1.0	2.8	1.8
Trunk predicted mass	0.3	1.9	3.9	-2.0	-0.7	1.7	-0.6
Standing height	0.1	1.5	2.7	-1.6	-1.0	1.3	-0.7
Length of working week for main job	3.3	3.7	4.9	1.7	2.2	-2.2	-1.5
Exposure to tobacco smoke at home	0.3	0.4	1.2	0.1	-1.1	-0.1	0.5
Breastfed as a baby	2.0	2.5	3.5	-0.8	-1.7	1.8	1.9
Tense / ‘highly strung’	1.7	2.8	5.1	1.7	0.5	-1.7	-2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	4.0	1.2	1.9	-2.0	-1.5
Hair/balding pattern: Pattern 4	0.8	2.0	2.9	1.5	1.4	-1.7	-0.9
Birth weight of first child	0.8	1.5	2.6	-1.2	-0.3	1.3	1.6
Peak expiratory flow (PEF)	1.2	2.7	5.7	1.4	0.8	-1.6	-2.4
Pulse wave reflection index	0.2	0.2	0.6	0.2	-0.8	-0.1	-0.3
Ever highly irritable/argumentative for 2 days	1.6	1.9	3.9	1.4	2.0	-1.2	-0.4
Loud music exposure frequency	0.2	0.2	0.7	-0.2	0.2	0.3	0.8
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.9	-0.1	0.9	-0.5	-0.6
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	3.3	-0.4	1.8	-1.5	-1.6
Blood clot in the leg (DVT)	1.3	1.7	4.3	-0.7	-0.6	2.1	1.3
Medication: Paracetamol	0.5	0.8	3.1	-0.2	-0.1	-0.4	1.8
Headache pain in last month	1.0	1.8	2.5	-1.6	-1.5	0.6	1.5
Medication for cholesterol, blood pressure or diabetes	2.9	4.9	7.2	2.7	1.9	-2.5	-1.6
Glaucoma (self-reported)	2.9	3.5	6.7	1.2	1.1	-2.1	-2.6
Gout (self-reported)	0.6	0.8	1.2	-1.0	-0.9	1.1	0.3
Hypothyroidism/myxoedema (self-reported)	1.8	3.6	9.3	1.6	3.0	-1.2	-1.0
Medication: Amlodipine	1.1	1.6	2.4	-1.5	-0.4	1.3	1.4
Medication: Ventolin 100micrograms inhaler	1.9	2.4	4.3	1.2	2.1	-1.4	-1.4
Birth weight	0.4	0.8	2.4	-1.6	0.0	0.8	0.4
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.6	0.1	0.6	-0.0	0.8
High blood pressure (siblings)	2.8	4.0	7.4	-2.7	-1.4	1.7	2.0
Forced vital capacity (FVC), Best measure	0.3	1.1	3.9	0.7	-0.1	-0.3	-2.0
Body fat percentage	2.2	8.7	13.7	-3.7	-1.1	3.3	3.0
Leg fat percentage (right)	1.2	4.3	8.1	-2.9	-0.2	2.4	1.9
Arm fat-free mass (right)	0.4	1.9	4.2	-2.0	-0.6	1.7	-0.2
Exposure to tobacco smoke outside home	0.2	0.2	0.5	0.6	0.1	-0.2	0.7
Comparative body size at age 10	0.2	0.5	1.1	0.4	0.9	-0.0	1.1
Number of full brothers	0.3	0.4	1.3	-1.2	-0.1	-0.2	-0.6
Worry too long after embarrassment	2.0	3.3	5.8	2.0	0.9	-2.4	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.6	0.8	1.3	-0.8	0.1
Wheeze or whistling in the chest in last year	0.1	0.1	0.3	-0.6	-0.0	0.5	-0.1
Number of children fathered	0.0	0.0	0.1	-0.0	0.0	0.4	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	-0.0	-0.1	-0.2	0.3
Age at first live birth	0.2	0.4	1.0	0.3	0.8	-1.0	-0.1
Pulse wave peak to peak time	0.8	0.9	2.5	-0.9	-0.4	0.3	1.6
Health satisfaction	0.0	0.0	0.1	0.0	0.1	-0.3	0.2
Shortness of breath walking on level ground	0.7	0.8	1.5	-1.2	-1.2	0.5	-0.1
Qualifications: College or University degree	0.1	0.4	0.9	0.0	-0.4	-0.6	-1.0
Eye problems/disorders: None of the above	1.0	1.2	3.7	0.1	-0.3	0.9	1.9
Mouth/teeth dental problems: Loose teeth	0.7	0.8	3.1	0.1	0.0	0.4	1.8
Emphysema/chronic bronchitis	4.1	4.6	6.0	-2.5	-2.2	1.8	2.0
Medication for pain relief, constipation, heartburn	2.8	4.8	10.0	2.2	1.0	-1.8	-3.2
Neck or shoulder pain in last month	0.8	1.2	2.0	-1.4	-0.6	1.4	0.6
Medication: Blood pressure	3.1	5.4	7.8	-2.7	-2.0	2.8	1.5
Angina (self-reported)	0.6	0.8	1.4	-1.2	0.3	1.0	0.9
Migraine (self-reported)	0.5	0.7	1.6	1.2	0.0	-0.9	0.5
Medication: Ibuprofen	0.3	0.4	1.5	-0.5	0.1	-0.0	1.2
Medication: Allopurinol	2.9	3.9	5.0	-2.1	-2.2	2.0	1.4
Medication: Omeprazole	3.6	4.2	6.7	-1.7	-2.6	2.0	1.9
Medication: Seretide 50 evohaler	1.7	1.9	2.4	-1.5	-1.6	1.4	1.1
Mean time to correctly identify matches	0.2	0.4	0.7	-0.6	0.1	0.8	0.8
Heart disease (mother)	0.1	0.1	0.2	0.2	0.4	0.1	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.0	-0.2	0.2	-0.8	1.0
Whole body fat mass	1.9	7.9	14.7	-3.8	-1.1	3.2	2.3
Leg fat mass (right)	1.4	5.6	11.6	-3.4	-0.4	2.8	1.7
Arm predicted mass (right)	0.4	1.9	4.1	-2.0	-0.7	1.8	0.0
Pulse rate, automated reading	0.0	0.1	0.4	-0.6	0.2	0.1	0.1
Alcohol intake frequency.	0.3	0.6	2.1	1.4	-0.2	-0.2	-0.4
Comparative height size at age 10	0.3	1.7	3.0	-1.7	-1.0	1.5	0.7
Number of full sisters	0.6	0.7	1.5	0.8	0.5	-0.5	-1.2
Suffer from ‘nerves’	2.4	3.7	6.6	2.2	1.1	-2.6	-1.4
Overall health rating	0.6	1.3	2.6	-1.6	-1.3	0.6	0.8
Chest pain or discomfort	1.2	1.7	2.7	-1.2	-0.9	1.4	1.6
Had major operations	1.3	1.5	3.5	-0.7	-0.9	1.1	1.9
Age at last live birth	0.8	1.1	1.7	0.4	0.9	-1.3	-1.3
Family relationship satisfaction	0.6	0.8	1.3	0.3	1.2	-1.1	-0.6
Leg pain on walking	1.0	1.2	1.8	-1.0	-1.3	1.3	0.7
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.7	4.9	2.2	1.1	-1.7	-1.4
Commuting to job workplace: Car/motor vehicle	1.0	1.1	1.8	1.1	1.4	-0.8	-0.9
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	3.3	1.8	0.7	-1.1	-0.9
Medication: Aspirin	1.4	1.8	3.2	-1.8	-0.7	1.4	1.2
Supplements: Vitamin C	0.2	0.2	0.6	0.6	0.1	-0.8	0.0
Knee pain experienced in last month	0.2	0.3	1.1	-1.1	0.4	-0.0	-0.2
Hypertension (Self-reported)	4.4	12.3	15.9	-3.6	-3.4	4.0	2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	3.3	-1.6	-1.1	1.8	1.3
Illnesses of father: Heart disease	2.8	3.9	6.6	1.2	2.6	-2.0	-1.9
Illnesses of siblings: Diabetes	0.4	0.5	0.9	0.8	1.0	-0.3	-0.6
Smoking status: Previous	0.7	1.0	1.7	-0.9	-0.2	1.3	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.0	0.3	1.0	0.0	-1.0
Whole body fat-free mass	0.4	2.5	5.4	-2.3	-0.9	1.9	-0.4
Leg fat-free mass (right)	0.6	3.1	6.7	-2.6	-1.2	2.1	0.0
Arm fat percentage (left)	1.8	7.2	13.1	-3.6	-1.1	3.0	2.4
Average weekly red wine intake	0.5	0.7	1.2	-0.7	-0.5	1.1	1.0
Handedness (chirality/laterality): Left-handed	3.2	3.8	5.9	2.4	1.7	-2.0	-1.6
Mood swings	0.9	1.6	2.6	0.6	1.5	-1.6	-1.1
Loneliness, isolation	1.1	1.5	3.5	0.8	1.9	-0.9	-1.0
Long-standing illness, disability or infirmity	0.5	0.8	1.9	0.2	1.4	-0.4	1.0
Ever had bowel cancer screening	0.7	0.8	1.5	-1.2	-0.4	0.7	1.1
Diabetes diagnosed by doctor	0.0	0.1	0.2	0.2	0.4	-0.2	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.4	-1.2	-0.4	1.0	1.2
Friendships satisfaction	0.4	0.4	1.1	0.4	0.4	-1.1	-0.5
Qualifications: nursing, teaching	1.2	1.9	3.9	1.0	1.2	-1.1	-2.0
Commuting to job workplace: Walk	1.1	1.2	4.0	-0.3	-2.0	0.5	-0.5
Eye problems/disorders: Cataract	0.1	0.1	0.6	0.0	-0.1	-0.0	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.5	-0.5	0.5	0.3	0.7
Medication for cholesterol	2.0	3.1	4.3	1.3	1.5	-2.0	-2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.5	-0.7	-0.3	0.6	0.6
Back pain experienced in last month	0.4	0.6	1.3	0.1	1.1	-0.4	-1.0
Mineral and other dietary supplements	1.0	1.3	3.2	1.8	0.9	-0.9	-0.7
Breast cancer (self-reported)	1.9	2.3	3.0	1.7	1.1	-1.5	-1.7
Asthma (self-reported)	0.2	0.4	0.7	0.7	0.8	-0.3	-0.6
Osteoporosis (self-reported)	0.3	0.3	1.1	1.1	-0.0	0.0	-0.3
Osteoarthritis (self-reported)	0.3	0.4	0.8	0.0	-0.5	0.7	0.9
Medication: Aspirin	1.7	2.2	2.8	-1.6	-1.0	1.7	1.5
Medication: Gliclazide	0.1	0.1	0.2	0.1	0.3	0.5	-0.2
Illnesses of father: None of the above (group 1)	0.3	0.3	1.3	0.2	-1.1	0.1	-0.1
Smoking status: Current	0.8	1.3	2.6	0.1	1.3	-1.6	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	1.7	1.3	0.6	-0.9	-1.2
Whole body water mass	0.4	2.3	5.2	-2.3	-0.8	1.8	-0.4
Leg predicted mass (right)	0.6	3.1	6.6	-2.6	-1.2	2.1	0.1
Arm fat mass (left)	1.6	6.4	13.1	-3.6	-1.0	2.9	1.8
Number of self-reported non-cancer illnesses	1.4	2.5	4.2	-1.7	-0.8	2.0	1.5
Average weekly champagne plus white wine intake	1.4	1.9	4.1	-1.6	-2.0	0.9	-0.3
Miserableness	0.2	0.4	1.1	-1.1	0.7	-0.3	-0.3
Guilty feelings	3.6	5.4	8.9	1.7	2.0	-3.0	-2.3
Wears glasses or contact lenses	0.2	0.2	0.4	0.5	0.3	-0.6	0.4
Ever taken oral contraceptive pill	0.4	0.4	0.8	0.5	0.5	-0.5	-0.9
Hearing aid user	0.2	0.2	0.4	-0.5	-0.1	0.5	-0.6
Mother’s age at death	1.1	1.4	5.3	0.5	-2.3	-0.1	-0.3
Financial situation satisfaction	1.1	1.3	3.2	-0.3	1.4	0.3	1.8
Tinnitus: Yes, now most or all of the time	0.9	1.0	2.4	-1.6	-0.9	1.0	-0.1
Commuting to job workplace: Public transport	3.6	4.3	7.3	-1.6	-2.7	1.8	2.0
Eye problems/disorders: Glaucoma	5.0	6.0	10.3	1.3	1.6	-3.1	-3.2
Medication: Blood pressure	4.1	7.8	8.5	-2.8	-2.5	2.9	2.9
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.3	-1.1	-1.1	0.0	0.7
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.0	-1.0	0.5	-0.2	-0.4
High cholesterol (Self-reported)	0.6	1.1	2.5	-1.6	-0.6	0.8	1.0
Medication: Bendroflumethiazide	1.0	1.5	2.9	-1.0	-0.7	1.1	1.7
Medication: Paracetamol	0.3	0.5	1.4	0.0	-0.2	-0.7	1.2
Medication: Lisinopril	3.6	4.6	7.7	-2.3	-1.1	2.8	2.1
Medication: Atorvastatin	0.5	0.6	1.0	-1.0	-0.0	0.9	0.9
Illnesses of father: High blood pressure	0.4	0.5	1.1	-0.6	-1.1	0.6	-0.3
Alcohol drinker status: Never	0.7	0.8	1.0	1.0	1.0	-0.7	-0.9
Ever smoked	0.2	0.4	1.2	-0.2	1.1	-0.6	0.1
Basal metabolic rate	0.6	3.6	8.0	-2.8	-1.1	2.2	0.1
Leg fat percentage (left)	1.5	5.5	8.6	-2.9	-0.6	2.8	2.3
Arm fat-free mass (left)	0.5	2.6	5.9	-2.4	-0.9	2.0	0.0
Number of operations (self-reported)	0.1	0.1	0.2	0.3	-0.1	-0.5	-0.1
Average weekly beer plus cider intake	0.3	0.4	0.6	-0.2	0.7	-0.7	-0.7
Irritability	0.2	0.4	0.8	-0.2	0.5	-0.6	-0.9
Risk taking	0.1	0.2	0.5	0.7	0.4	0.2	0.0
Ever had prostate specific antigen (PSA) test	1.5	1.8	3.7	-0.8	-1.9	1.2	1.1
Fractured/broken bones in last 5 years	1.6	2.1	4.8	-0.5	-1.5	0.9	2.2
Age started oral contraceptive pill	0.2	0.2	0.5	-0.7	-0.3	0.3	0.5
Diastolic blood pressure, automated reading	1.5	4.8	6.9	-2.4	-2.6	1.9	1.7
Ever depressed for a whole week	0.7	0.9	2.6	-0.2	1.6	-0.8	0.6
Unable to work because of sickness or disability	1.0	1.3	2.3	0.9	1.4	-1.5	-0.5
Commuting to job workplace: Cycle	1.5	1.8	2.7	-1.6	-1.5	0.4	1.4
Myopia	1.3	1.9	3.6	-1.9	-0.5	1.2	1.6
Vascular/heart problems diagnosed by doctor	5.3	14.4	20.4	4.1	3.4	-4.5	-3.0
Cholesterol lowering medication	0.2	0.3	0.5	0.4	0.3	-0.7	-0.7
Medication: Omeprazole (e.g. Zanprol)	2.4	2.9	4.0	-1.4	-2.0	1.7	1.6
Pain experienced in last month	1.2	2.0	6.0	2.4	0.9	-0.9	-0.6
Supplements: Calcium	2.6	2.8	6.7	-0.3	-2.6	1.3	1.6
Basal cell carcinoma (self-reported)	1.0	1.2	2.3	1.3	0.9	-1.5	-0.1
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.2	-0.9	-0.2	0.4	1.8
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	3.9	-0.8	-0.6	2.0	1.3
Heart disease (siblings)	0.3	0.4	0.6	-0.1	0.8	0.6	0.8
Alcohol drinker status: Previous	0.6	0.7	1.5	0.2	-1.0	-0.3	1.2
Pack years of smoking	0.4	0.5	0.8	-0.8	-0.5	0.6	0.9
Impedance of whole body	0.1	0.6	1.3	0.9	0.4	-1.1	0.1
Leg fat mass (left)	1.5	6.0	11.2	-3.3	-0.7	3.0	1.9
Arm predicted mass (left)	0.4	2.2	4.8	-2.2	-0.7	1.9	-0.0