Hub : Genes

PPIH

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Breast Mammary Tissue (Female) 0.0685 0.0577 0.14000 -0.007 NA -0.008 NA -0.006 5.9e-01 NA 6.6e-01 NA 5.5e-01
2 GTEx Testis 0.5400 0.0750 0.00000 0.622 NA 0.582 NA 0.596 1.4e-34 NA 3.2e-31 NA 2.6e-32
3 YFS Blood 0.0118 0.0062 0.00690 0.010 0.004 0.010 0.005 0.012 2.8e-04 0.0120 2.9e-04 0.0053 6.8e-05
4 TCGA Prostate Adenocarcinoma 0.0449 0.0275 0.00072 0.015 0.015 0.021 NA 0.013 8.9e-03 0.0089 2.3e-03 NA 1.5e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.4 0.6 1.4 -0.0 0.1 1.0 1.2
Bipolar Disorder or Schizophrenia 0.0 0.1 0.2 0.4 0.5 0.2 -0.1
Depressed Affect (Nagel 2018) 0.6 1.3 3.1 0.2 1.8 -1.2 -0.7
Depression (Nagel 2018) 1.1 1.6 3.8 0.5 1.2 -2.0 -0.9
Intelligence (Savage-Jansen 2018) 0.4 1.3 2.1 -1.4 -1.4 1.1 0.2
Neuroticism (Nagel 2018) 1.8 4.3 8.9 1.7 2.1 -3.0 -1.0
Schizophrenia (2018) 0.2 0.5 1.1 0.5 0.6 -0.5 -1.1
Schizophrenia vs Biploar Disorder 0.2 0.3 0.9 -0.2 0.1 -0.4 -0.9
Worry (Nagel 2018) 4.0 8.3 15.4 3.1 1.3 -3.9 -2.6
Alzheimer’s Disease (in mother) 0.2 0.2 0.6 0.2 -0.2 0.5 0.8
Alzheimer’s Disease (in father) 0.6 0.7 2.3 -0.3 0.3 0.4 1.5
Alzheimer’s Disease (including proxy) 0.2 0.2 0.5 0.2 0.6 -0.2 0.7
Crohns Disease (2017) 2.7 5.9 9.9 1.7 3.1 -2.4 -2.3
Irritable Bowel Disease (IBD) 1.6 3.8 6.1 1.3 2.5 -1.8 -2.0
Ulcerative Colitis (UC) 0.0 0.1 0.1 0.2 0.1 0.3 -0.3
Major Depression (MDD) 0.1 0.2 0.3 -0.2 0.5 0.2 0.5
Reaction Time 0.5 1.0 1.9 -0.7 -0.1 1.2 1.4
Verbal and Numeric Reasoning (VNR) 0.3 0.8 2.9 -0.1 -0.1 -0.6 -1.7
Breast Cancer 0.2 0.6 1.2 0.6 -1.1 -0.7 -0.5
Ovarian Cancer 1.5 2.0 2.5 1.5 1.0 -1.5 -1.6
Prostate Cancer 0.8 1.1 2.7 1.6 0.2 -1.3 -0.2
Age at First Birth 0.3 0.4 0.7 -0.3 -0.9 0.5 0.6
Bipolar Disorder (2011) 0.3 0.3 0.8 -0.9 0.4 0.3 0.3
Body Mass Index (BMI) (2010) 1.6 2.2 3.9 1.4 0.9 -2.0 -1.6
Coronary Artery Disease (CAD) 0.1 0.1 0.2 -0.3 0.3 0.5 -0.0
Crohns Disease (2012) 3.8 6.2 9.7 2.1 3.1 -2.7 -1.8
Mean Putamen Volume 0.2 0.2 0.3 0.5 0.6 -0.5 -0.0
Fasting Glucose 1.8 2.2 3.1 1.6 0.7 -1.6 -1.8
HbA1C 0.2 0.2 0.6 0.1 -0.1 -0.1 0.8
HDL Cholesterol 0.1 0.1 0.3 0.3 -0.2 -0.3 0.5
LDL Cholesterol 0.8 1.2 1.9 -1.1 -1.4 1.3 0.2
Lupus 1.2 1.8 2.6 -1.6 -1.4 1.1 1.2
Neuroticism (2016) 1.1 1.6 3.0 0.9 1.7 -1.4 -0.8
Primary Biliary Cirrhosis 0.6 0.9 1.7 -1.1 -0.0 0.8 1.3
Rheumatoid Arthritis 0.1 0.1 0.4 -0.1 -0.2 -0.6 -0.2
Schizophrenia (2014) 0.1 0.3 0.8 -0.0 0.9 -0.3 -0.6
Triglycerides 0.1 0.1 0.2 0.4 -0.3 -0.2 -0.4
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.2 1.1 0.8 -0.6 0.1
Ulcerative Colitis 0.7 1.0 1.8 -1.3 -0.9 0.9 0.7
Blood Eosinophil Count 0.5 3.8 10.9 1.4 3.3 -1.1 -1.0
Blood Platelet Count 0.4 5.1 8.0 -2.5 -0.1 2.8 2.5
Blood Red Count 0.0 0.1 0.3 0.1 0.5 0.0 -0.5
Blood White Count 2.8 20.9 30.8 3.1 4.7 -5.5 -4.5
Heel T-Score 0.0 0.1 0.4 -0.4 -0.6 0.2 -0.1
BMI 0.5 2.9 4.1 -1.9 -0.5 2.0 1.9
Height 0.5 10.6 15.8 -4.0 -3.4 3.9 0.3
Waist Hip Ratio (WHR) 0.0 0.1 0.2 -0.5 0.5 0.2 -0.3
Systolic Blood Pressure 0.4 1.9 3.4 -1.1 -1.8 1.6 -0.7
Smoking Status 0.4 0.9 2.5 -0.6 1.6 -0.6 0.5
Allergy or Eczema 0.2 0.5 1.7 0.6 0.0 -1.3 -0.4
Cardiovascular Disease 2.4 7.9 10.2 -3.2 -2.3 3.1 2.6
Hypothyroidism (self reported) 3.1 7.2 13.8 2.5 3.7 -2.1 -2.1
Respiratory disease 0.9 2.1 4.5 2.1 1.3 -1.3 -0.4
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.7 0.3 0.9 -0.8 0.1
Lung FEV1/FVC ratio 0.0 0.1 0.2 0.0 0.0 -0.2 -0.5
Lung FVC 0.7 3.3 4.0 1.9 1.7 -1.7 -2.0
Neuroticism 0.9 2.2 5.1 1.1 0.8 -2.3 -1.4
Chronotype (morning person) 0.1 0.2 0.4 0.2 -0.6 -0.2 0.4
Hair Pigment 0.2 4.9 14.6 1.9 3.8 -1.0 -0.3
Tanning 0.0 0.1 0.3 -0.2 0.4 -0.1 0.6
Hand grip strength (left) 0.1 0.3 0.8 -0.3 0.5 0.4 -0.9
Number of treatments/medications taken 0.3 0.6 1.8 -1.4 -0.1 0.1 0.6
Average weekly spirits intake 2.0 2.5 4.5 -1.6 -0.4 1.7 2.1
Sensitivity / hurt feelings 0.0 0.1 0.2 -0.4 -0.1 -0.4 0.0
Frequency of depressed mood in last 2 weeks 0.8 1.1 3.0 0.5 0.5 -1.7 -1.0
Hearing difficulty/problems: Yes 0.3 0.4 0.8 -0.4 -0.9 0.5 -0.6
Relative age of first facial hair 0.1 0.2 0.6 -0.1 -0.1 0.1 -0.8
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.4 -0.6 -0.3 -0.3 0.3
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.4 0.4 -1.2 -0.0 -0.2
Ever had hysterectomy (womb removed) 0.4 0.4 0.8 0.4 0.8 -0.9 -0.1
Systolic blood pressure, automated reading 0.8 2.3 4.1 -1.6 -1.4 2.0 0.6
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 1.4 0.3 0.8 -0.9 -1.2
Angina 0.5 0.7 1.1 -1.0 0.6 0.9 0.7
Medication for hormone replacement therapy 1.0 1.1 2.7 -0.2 -1.0 1.6 0.8
Vitamin and mineral supplements 2.0 2.7 4.9 1.7 2.2 -1.1 -1.2
Supplements: Zinc 0.5 0.5 0.7 -0.3 -0.8 0.9 0.7
Medication: Co-codamol 2.4 2.8 4.0 -1.4 -1.7 2.0 1.6
Medication: Metformin 0.2 0.3 0.7 0.7 0.8 -0.2 -0.2
Diabetes (father) 0.2 0.3 0.8 0.3 0.9 -0.5 -0.2
Diabetes (mother) 0.2 0.2 0.6 0.3 0.8 -0.3 -0.3
Severe depression (siblings) 0.4 0.4 1.1 -1.0 0.5 -0.4 0.4
Pack years adult smoking proportion 0.0 0.1 0.1 -0.4 -0.1 0.1 0.3
Impedance of leg (right) 0.4 2.1 3.5 1.5 1.4 -1.9 -0.8
Leg fat-free mass (left) 0.6 3.1 7.6 -2.8 -1.0 1.9 -0.1
Trunk fat percentage 2.0 7.9 13.2 -3.6 -1.2 3.0 2.8
Hand grip strength (right) 0.6 1.7 4.7 1.0 1.0 -0.3 -2.2
Townsend deprivation index at recruitment 2.0 2.8 3.8 -1.9 -1.2 1.8 1.7
Current tobacco smoking 1.3 2.1 4.3 0.6 1.6 -2.1 -1.1
Average weekly fortified wine intake 0.2 0.3 0.9 0.1 -0.4 -0.2 -0.9
Maternal smoking around birth 1.7 2.5 5.8 -1.4 -0.8 1.2 2.4
Fed-up feelings 0.2 0.3 0.7 0.4 0.9 -0.1 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 0.8 0.4 0.9 -0.6 -0.8
Relative age voice broke 1.6 2.5 6.7 1.6 -0.4 -0.7 -2.6
Taking other prescription medications 0.2 0.3 0.8 0.1 0.9 -0.6 0.5
Age when periods started (menarche) 0.5 1.1 2.2 -1.5 -0.4 0.8 1.2
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.3 0.5 0.3 0.3 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.4 0.5 -1.2 0.2 -0.4
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.6 -0.5 0.8 0.1 -0.3
Qualifications: CSEs or equivalent 3.0 4.0 7.9 -1.5 -1.0 2.2 2.8
Serious illness, injury or assault to yourself 0.6 0.8 2.4 0.1 -0.8 -0.3 -1.5
High blood pressure 4.1 11.3 16.0 -3.5 -3.2 4.0 2.6
Hayfever, allergic rhinitis or eczema 0.2 0.5 1.6 0.3 0.4 -1.2 -0.3
Multivitamins +/- minerals 0.7 0.9 1.9 -1.4 -1.0 0.7 0.3
Stomach or abdominal pain in last month 3.5 4.4 6.6 -2.6 -2.6 1.5 1.4
Supplements: Glucosamine 1.1 1.4 2.0 -1.1 -0.7 1.3 1.4
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.7 -0.8 -0.0 0.4 0.7
Medication: Atenolol 3.0 3.8 9.6 -3.1 -0.7 1.9 1.3
Medication: Levothyroxine sodium 1.0 1.7 3.7 0.9 1.9 -1.0 -1.0
Sitting height 0.2 1.6 5.4 0.2 0.5 -0.8 -2.3
Chronic bronchitis/emphysema (father) 0.6 0.7 1.3 0.5 0.9 -1.1 -0.6
High blood pressure (mother) 0.2 0.3 0.5 -0.7 -0.7 0.3 0.1
Body mass index (BMI) 1.2 5.1 8.6 -2.9 -1.1 2.6 1.9
Impedance of leg (left) 0.2 1.2 2.2 1.5 1.1 -1.2 -0.0
Leg predicted mass (left) 0.6 3.1 7.4 -2.7 -1.1 1.9 -0.1
Trunk fat mass 1.8 7.8 14.5 -3.8 -1.2 3.2 2.3
Waist circumference 1.9 7.1 13.5 -3.7 -1.5 3.1 1.6
Number of incorrect matches in round 0.3 0.4 1.3 0.2 0.1 0.6 1.1
Past tobacco smoking 0.6 1.0 1.8 1.2 -0.1 -0.9 -1.3
Alcohol usually taken with meals 0.7 1.2 3.0 -0.5 -1.7 0.9 0.9
Nervous feelings 1.6 3.0 7.9 1.1 0.7 -2.8 -1.6
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.0 2.0 0.7 0.7 -1.4 -1.1
Hearing difficulty/problems with background noise 0.9 1.4 3.2 -1.3 -1.8 0.7 0.4
Hair/balding pattern: Pattern 2 5.5 7.0 10.5 -2.1 -2.7 3.2 2.4
Had menopause 2.6 3.3 5.6 -2.4 -1.3 1.5 1.9
Had other major operations 0.9 1.0 2.7 0.6 -0.1 -1.1 -1.6
Forced vital capacity (FVC) 0.5 1.9 4.2 1.3 0.9 -1.0 -2.0
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 1.2 0.5 -0.8 -0.6 -1.1
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 1.7 -0.3 1.3 -0.1 1.2
Qualifications: None of the above 1.2 2.6 4.5 -1.2 -0.1 2.1 2.1
Financial difficulties in last 2 years 0.9 1.3 2.3 -1.0 0.0 1.3 1.5
Mouth/teeth dental problems 0.9 1.4 4.7 -0.1 -2.2 0.9 0.3
Heart attack 1.0 1.3 4.4 -0.9 -0.1 0.4 2.1
Allergy 0.2 0.4 0.9 0.4 0.6 -0.2 -1.0
Pain all over the body in last month 0.7 0.8 1.7 0.7 1.3 -0.9 -0.2
Diabetes (self-reported) 0.1 0.1 0.2 -0.5 -0.4 -0.1 0.1
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.2 1.1 -0.4 -0.4 -0.2
Medication: Ramipril 0.1 0.1 0.3 -0.0 -0.5 0.2 -0.3
Medication: Simvastatin 0.3 0.4 0.9 -0.9 -0.3 0.1 0.7
Fluid intelligence score 0.3 0.6 1.7 0.2 -0.6 -0.5 -1.3
Illnesses of siblings 0.4 0.6 1.7 1.3 0.1 -0.8 -0.3
Neuroticism score 1.2 2.4 4.6 1.0 0.8 -2.1 -1.8
Weight 1.3 6.4 12.5 -3.5 -1.4 3.1 1.4
Impedance of arm (right) 0.1 0.3 0.9 0.4 0.2 -0.9 -0.0
Arm fat percentage (right) 1.9 7.6 13.2 -3.6 -1.2 3.1 2.5
Trunk fat-free mass 0.3 1.9 3.9 -2.0 -0.7 1.7 -0.7
Hip circumference 1.1 4.7 8.9 -3.0 -1.8 2.4 0.9
Time employed in main current job 1.7 1.9 2.2 1.3 1.5 -1.3 -1.4
Alcohol intake versus 10 years previously 0.7 1.1 1.8 1.3 1.2 -0.8 -0.6
Father’s age at death 0.1 0.2 0.6 -0.2 -0.8 -0.2 -0.1
Worrier / anxious feelings 1.1 2.1 4.5 1.1 0.6 -2.1 -1.6
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.8 4.8 0.7 0.9 -1.1 -2.2
Falls in the last year 0.4 0.5 1.0 -1.0 0.2 0.8 0.7
Hair/balding pattern: Pattern 3 0.1 0.1 0.3 -0.1 -0.5 -0.3 -0.3
Number of live births 1.5 2.1 4.8 2.2 1.5 -0.7 -1.0
Forced expiratory volume in 1-second (FEV1) 0.8 2.8 4.9 1.7 1.0 -1.6 -2.2
Pulse rate 0.9 1.6 5.0 1.0 2.2 -0.5 0.1
Happiness 0.4 0.5 1.2 -0.7 -0.1 -1.1 -0.4
Noisy workplace 0.3 0.4 0.9 0.2 -0.5 0.5 -0.9
Qualifications: A levels/AS levels or equivalent 1.3 2.9 6.7 1.4 0.2 -1.7 -2.6
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 2.8 -0.1 0.6 -1.3 -1.7
Mouth/teeth dental problems: Dentures 0.2 0.4 1.0 0.5 1.0 -0.5 -0.1
Asthma 0.1 0.2 0.3 0.5 0.5 -0.2 -0.4
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.4 1.6 -0.4 0.0 0.1 1.3
Medication: Cholesterol lowering 3.6 5.6 9.1 -3.0 -1.4 2.4 2.3
Depression (self-reported) 0.3 0.4 0.9 -0.9 -0.3 -0.6 0.4
Medication: Lansoprazole 0.4 0.5 1.6 -1.3 0.4 0.4 0.1
Prospective memory result 0.1 0.2 0.4 0.5 0.6 -0.2 -0.0
Lung cancer (father) 0.9 1.1 2.3 0.8 -0.3 -1.1 -1.5
Illnesses of mother 0.2 0.3 0.4 0.4 0.3 -0.6 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.7 4.8 1.0 0.1 -1.0 -2.2
Pulse wave Arterial Stiffness index 0.7 0.9 2.4 0.9 0.4 -0.3 -1.6
Impedance of arm (left) 0.0 0.2 0.5 0.2 -0.1 -0.7 0.3
Arm fat mass (right) 1.5 6.0 11.6 -3.4 -1.0 2.8 1.8
Trunk predicted mass 0.3 1.9 3.9 -2.0 -0.7 1.7 -0.6
Standing height 0.1 1.5 2.7 -1.6 -1.0 1.3 -0.7
Length of working week for main job 3.3 3.7 4.9 1.7 2.2 -2.2 -1.5
Exposure to tobacco smoke at home 0.3 0.4 1.2 0.1 -1.1 -0.1 0.5
Breastfed as a baby 2.0 2.5 3.5 -0.8 -1.7 1.8 1.9
Tense / ‘highly strung’ 1.7 2.8 5.1 1.7 0.5 -1.7 -2.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.9 2.9 4.0 1.2 1.9 -2.0 -1.5
Hair/balding pattern: Pattern 4 0.8 2.0 2.9 1.5 1.4 -1.7 -0.9
Birth weight of first child 0.8 1.5 2.6 -1.2 -0.3 1.3 1.6
Peak expiratory flow (PEF) 1.2 2.7 5.7 1.4 0.8 -1.6 -2.4
Pulse wave reflection index 0.2 0.2 0.6 0.2 -0.8 -0.1 -0.3
Ever highly irritable/argumentative for 2 days 1.6 1.9 3.9 1.4 2.0 -1.2 -0.4
Loud music exposure frequency 0.2 0.2 0.7 -0.2 0.2 0.3 0.8
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 0.9 -0.1 0.9 -0.5 -0.6
Mouth/teeth dental problems: Bleeding gums 1.6 2.1 3.3 -0.4 1.8 -1.5 -1.6
Blood clot in the leg (DVT) 1.3 1.7 4.3 -0.7 -0.6 2.1 1.3
Medication: Paracetamol 0.5 0.8 3.1 -0.2 -0.1 -0.4 1.8
Headache pain in last month 1.0 1.8 2.5 -1.6 -1.5 0.6 1.5
Medication for cholesterol, blood pressure or diabetes 2.9 4.9 7.2 2.7 1.9 -2.5 -1.6
Glaucoma (self-reported) 2.9 3.5 6.7 1.2 1.1 -2.1 -2.6
Gout (self-reported) 0.6 0.8 1.2 -1.0 -0.9 1.1 0.3
Hypothyroidism/myxoedema (self-reported) 1.8 3.6 9.3 1.6 3.0 -1.2 -1.0
Medication: Amlodipine 1.1 1.6 2.4 -1.5 -0.4 1.3 1.4
Medication: Ventolin 100micrograms inhaler 1.9 2.4 4.3 1.2 2.1 -1.4 -1.4
Birth weight 0.4 0.8 2.4 -1.6 0.0 0.8 0.4
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.6 0.1 0.6 -0.0 0.8
High blood pressure (siblings) 2.8 4.0 7.4 -2.7 -1.4 1.7 2.0
Forced vital capacity (FVC), Best measure 0.3 1.1 3.9 0.7 -0.1 -0.3 -2.0
Body fat percentage 2.2 8.7 13.7 -3.7 -1.1 3.3 3.0
Leg fat percentage (right) 1.2 4.3 8.1 -2.9 -0.2 2.4 1.9
Arm fat-free mass (right) 0.4 1.9 4.2 -2.0 -0.6 1.7 -0.2
Exposure to tobacco smoke outside home 0.2 0.2 0.5 0.6 0.1 -0.2 0.7
Comparative body size at age 10 0.2 0.5 1.1 0.4 0.9 -0.0 1.1
Number of full brothers 0.3 0.4 1.3 -1.2 -0.1 -0.2 -0.6
Worry too long after embarrassment 2.0 3.3 5.8 2.0 0.9 -2.4 -1.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.6 0.8 1.3 -0.8 0.1
Wheeze or whistling in the chest in last year 0.1 0.1 0.3 -0.6 -0.0 0.5 -0.1
Number of children fathered 0.0 0.0 0.1 -0.0 0.0 0.4 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.0 0.0 0.1 -0.0 -0.1 -0.2 0.3
Age at first live birth 0.2 0.4 1.0 0.3 0.8 -1.0 -0.1
Pulse wave peak to peak time 0.8 0.9 2.5 -0.9 -0.4 0.3 1.6
Health satisfaction 0.0 0.0 0.1 0.0 0.1 -0.3 0.2
Shortness of breath walking on level ground 0.7 0.8 1.5 -1.2 -1.2 0.5 -0.1
Qualifications: College or University degree 0.1 0.4 0.9 0.0 -0.4 -0.6 -1.0
Eye problems/disorders: None of the above 1.0 1.2 3.7 0.1 -0.3 0.9 1.9
Mouth/teeth dental problems: Loose teeth 0.7 0.8 3.1 0.1 0.0 0.4 1.8
Emphysema/chronic bronchitis 4.1 4.6 6.0 -2.5 -2.2 1.8 2.0
Medication for pain relief, constipation, heartburn 2.8 4.8 10.0 2.2 1.0 -1.8 -3.2
Neck or shoulder pain in last month 0.8 1.2 2.0 -1.4 -0.6 1.4 0.6
Medication: Blood pressure 3.1 5.4 7.8 -2.7 -2.0 2.8 1.5
Angina (self-reported) 0.6 0.8 1.4 -1.2 0.3 1.0 0.9
Migraine (self-reported) 0.5 0.7 1.6 1.2 0.0 -0.9 0.5
Medication: Ibuprofen 0.3 0.4 1.5 -0.5 0.1 -0.0 1.2
Medication: Allopurinol 2.9 3.9 5.0 -2.1 -2.2 2.0 1.4
Medication: Omeprazole 3.6 4.2 6.7 -1.7 -2.6 2.0 1.9
Medication: Seretide 50 evohaler 1.7 1.9 2.4 -1.5 -1.6 1.4 1.1
Mean time to correctly identify matches 0.2 0.4 0.7 -0.6 0.1 0.8 0.8
Heart disease (mother) 0.1 0.1 0.2 0.2 0.4 0.1 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 1.0 -0.2 0.2 -0.8 1.0
Whole body fat mass 1.9 7.9 14.7 -3.8 -1.1 3.2 2.3
Leg fat mass (right) 1.4 5.6 11.6 -3.4 -0.4 2.8 1.7
Arm predicted mass (right) 0.4 1.9 4.1 -2.0 -0.7 1.8 0.0
Pulse rate, automated reading 0.0 0.1 0.4 -0.6 0.2 0.1 0.1
Alcohol intake frequency. 0.3 0.6 2.1 1.4 -0.2 -0.2 -0.4
Comparative height size at age 10 0.3 1.7 3.0 -1.7 -1.0 1.5 0.7
Number of full sisters 0.6 0.7 1.5 0.8 0.5 -0.5 -1.2
Suffer from ‘nerves’ 2.4 3.7 6.6 2.2 1.1 -2.6 -1.4
Overall health rating 0.6 1.3 2.6 -1.6 -1.3 0.6 0.8
Chest pain or discomfort 1.2 1.7 2.7 -1.2 -0.9 1.4 1.6
Had major operations 1.3 1.5 3.5 -0.7 -0.9 1.1 1.9
Age at last live birth 0.8 1.1 1.7 0.4 0.9 -1.3 -1.3
Family relationship satisfaction 0.6 0.8 1.3 0.3 1.2 -1.1 -0.6
Leg pain on walking 1.0 1.2 1.8 -1.0 -1.3 1.3 0.7
Qualifications: NVQ or HND or HNC or equivalent 2.3 2.7 4.9 2.2 1.1 -1.7 -1.4
Commuting to job workplace: Car/motor vehicle 1.0 1.1 1.8 1.1 1.4 -0.8 -0.9
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 3.3 1.8 0.7 -1.1 -0.9
Medication: Aspirin 1.4 1.8 3.2 -1.8 -0.7 1.4 1.2
Supplements: Vitamin C 0.2 0.2 0.6 0.6 0.1 -0.8 0.0
Knee pain experienced in last month 0.2 0.3 1.1 -1.1 0.4 -0.0 -0.2
Hypertension (Self-reported) 4.4 12.3 15.9 -3.6 -3.4 4.0 2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.9 2.2 3.3 -1.6 -1.1 1.8 1.3
Illnesses of father: Heart disease 2.8 3.9 6.6 1.2 2.6 -2.0 -1.9
Illnesses of siblings: Diabetes 0.4 0.5 0.9 0.8 1.0 -0.3 -0.6
Smoking status: Previous 0.7 1.0 1.7 -0.9 -0.2 1.3 1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.0 0.3 1.0 0.0 -1.0
Whole body fat-free mass 0.4 2.5 5.4 -2.3 -0.9 1.9 -0.4
Leg fat-free mass (right) 0.6 3.1 6.7 -2.6 -1.2 2.1 0.0
Arm fat percentage (left) 1.8 7.2 13.1 -3.6 -1.1 3.0 2.4
Average weekly red wine intake 0.5 0.7 1.2 -0.7 -0.5 1.1 1.0
Handedness (chirality/laterality): Left-handed 3.2 3.8 5.9 2.4 1.7 -2.0 -1.6
Mood swings 0.9 1.6 2.6 0.6 1.5 -1.6 -1.1
Loneliness, isolation 1.1 1.5 3.5 0.8 1.9 -0.9 -1.0
Long-standing illness, disability or infirmity 0.5 0.8 1.9 0.2 1.4 -0.4 1.0
Ever had bowel cancer screening 0.7 0.8 1.5 -1.2 -0.4 0.7 1.1
Diabetes diagnosed by doctor 0.0 0.1 0.2 0.2 0.4 -0.2 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 1.4 -1.2 -0.4 1.0 1.2
Friendships satisfaction 0.4 0.4 1.1 0.4 0.4 -1.1 -0.5
Qualifications: nursing, teaching 1.2 1.9 3.9 1.0 1.2 -1.1 -2.0
Commuting to job workplace: Walk 1.1 1.2 4.0 -0.3 -2.0 0.5 -0.5
Eye problems/disorders: Cataract 0.1 0.1 0.6 0.0 -0.1 -0.0 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.5 -0.5 0.5 0.3 0.7
Medication for cholesterol 2.0 3.1 4.3 1.3 1.5 -2.0 -2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.5 -0.7 -0.3 0.6 0.6
Back pain experienced in last month 0.4 0.6 1.3 0.1 1.1 -0.4 -1.0
Mineral and other dietary supplements 1.0 1.3 3.2 1.8 0.9 -0.9 -0.7
Breast cancer (self-reported) 1.9 2.3 3.0 1.7 1.1 -1.5 -1.7
Asthma (self-reported) 0.2 0.4 0.7 0.7 0.8 -0.3 -0.6
Osteoporosis (self-reported) 0.3 0.3 1.1 1.1 -0.0 0.0 -0.3
Osteoarthritis (self-reported) 0.3 0.4 0.8 0.0 -0.5 0.7 0.9
Medication: Aspirin 1.7 2.2 2.8 -1.6 -1.0 1.7 1.5
Medication: Gliclazide 0.1 0.1 0.2 0.1 0.3 0.5 -0.2
Illnesses of father: None of the above (group 1) 0.3 0.3 1.3 0.2 -1.1 0.1 -0.1
Smoking status: Current 0.8 1.3 2.6 0.1 1.3 -1.6 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 1.7 1.3 0.6 -0.9 -1.2
Whole body water mass 0.4 2.3 5.2 -2.3 -0.8 1.8 -0.4
Leg predicted mass (right) 0.6 3.1 6.6 -2.6 -1.2 2.1 0.1
Arm fat mass (left) 1.6 6.4 13.1 -3.6 -1.0 2.9 1.8
Number of self-reported non-cancer illnesses 1.4 2.5 4.2 -1.7 -0.8 2.0 1.5
Average weekly champagne plus white wine intake 1.4 1.9 4.1 -1.6 -2.0 0.9 -0.3
Miserableness 0.2 0.4 1.1 -1.1 0.7 -0.3 -0.3
Guilty feelings 3.6 5.4 8.9 1.7 2.0 -3.0 -2.3
Wears glasses or contact lenses 0.2 0.2 0.4 0.5 0.3 -0.6 0.4
Ever taken oral contraceptive pill 0.4 0.4 0.8 0.5 0.5 -0.5 -0.9
Hearing aid user 0.2 0.2 0.4 -0.5 -0.1 0.5 -0.6
Mother’s age at death 1.1 1.4 5.3 0.5 -2.3 -0.1 -0.3
Financial situation satisfaction 1.1 1.3 3.2 -0.3 1.4 0.3 1.8
Tinnitus: Yes, now most or all of the time 0.9 1.0 2.4 -1.6 -0.9 1.0 -0.1
Commuting to job workplace: Public transport 3.6 4.3 7.3 -1.6 -2.7 1.8 2.0
Eye problems/disorders: Glaucoma 5.0 6.0 10.3 1.3 1.6 -3.1 -3.2
Medication: Blood pressure 4.1 7.8 8.5 -2.8 -2.5 2.9 2.9
Pain type(s) experienced in last month: Hip pain 0.6 0.7 1.3 -1.1 -1.1 0.0 0.7
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.0 -1.0 0.5 -0.2 -0.4
High cholesterol (Self-reported) 0.6 1.1 2.5 -1.6 -0.6 0.8 1.0
Medication: Bendroflumethiazide 1.0 1.5 2.9 -1.0 -0.7 1.1 1.7
Medication: Paracetamol 0.3 0.5 1.4 0.0 -0.2 -0.7 1.2
Medication: Lisinopril 3.6 4.6 7.7 -2.3 -1.1 2.8 2.1
Medication: Atorvastatin 0.5 0.6 1.0 -1.0 -0.0 0.9 0.9
Illnesses of father: High blood pressure 0.4 0.5 1.1 -0.6 -1.1 0.6 -0.3
Alcohol drinker status: Never 0.7 0.8 1.0 1.0 1.0 -0.7 -0.9
Ever smoked 0.2 0.4 1.2 -0.2 1.1 -0.6 0.1
Basal metabolic rate 0.6 3.6 8.0 -2.8 -1.1 2.2 0.1
Leg fat percentage (left) 1.5 5.5 8.6 -2.9 -0.6 2.8 2.3
Arm fat-free mass (left) 0.5 2.6 5.9 -2.4 -0.9 2.0 0.0
Number of operations (self-reported) 0.1 0.1 0.2 0.3 -0.1 -0.5 -0.1
Average weekly beer plus cider intake 0.3 0.4 0.6 -0.2 0.7 -0.7 -0.7
Irritability 0.2 0.4 0.8 -0.2 0.5 -0.6 -0.9
Risk taking 0.1 0.2 0.5 0.7 0.4 0.2 0.0
Ever had prostate specific antigen (PSA) test 1.5 1.8 3.7 -0.8 -1.9 1.2 1.1
Fractured/broken bones in last 5 years 1.6 2.1 4.8 -0.5 -1.5 0.9 2.2
Age started oral contraceptive pill 0.2 0.2 0.5 -0.7 -0.3 0.3 0.5
Diastolic blood pressure, automated reading 1.5 4.8 6.9 -2.4 -2.6 1.9 1.7
Ever depressed for a whole week 0.7 0.9 2.6 -0.2 1.6 -0.8 0.6
Unable to work because of sickness or disability 1.0 1.3 2.3 0.9 1.4 -1.5 -0.5
Commuting to job workplace: Cycle 1.5 1.8 2.7 -1.6 -1.5 0.4 1.4
Myopia 1.3 1.9 3.6 -1.9 -0.5 1.2 1.6
Vascular/heart problems diagnosed by doctor 5.3 14.4 20.4 4.1 3.4 -4.5 -3.0
Cholesterol lowering medication 0.2 0.3 0.5 0.4 0.3 -0.7 -0.7
Medication: Omeprazole (e.g. Zanprol) 2.4 2.9 4.0 -1.4 -2.0 1.7 1.6
Pain experienced in last month 1.2 2.0 6.0 2.4 0.9 -0.9 -0.6
Supplements: Calcium 2.6 2.8 6.7 -0.3 -2.6 1.3 1.6
Basal cell carcinoma (self-reported) 1.0 1.2 2.3 1.3 0.9 -1.5 -0.1
Heart attack/myocardial infarction (self-reported) 0.8 1.0 3.2 -0.9 -0.2 0.4 1.8
Deep venous thrombosis (DVT) (self-reported) 1.3 1.6 3.9 -0.8 -0.6 2.0 1.3
Heart disease (siblings) 0.3 0.4 0.6 -0.1 0.8 0.6 0.8
Alcohol drinker status: Previous 0.6 0.7 1.5 0.2 -1.0 -0.3 1.2
Pack years of smoking 0.4 0.5 0.8 -0.8 -0.5 0.6 0.9
Impedance of whole body 0.1 0.6 1.3 0.9 0.4 -1.1 0.1
Leg fat mass (left) 1.5 6.0 11.2 -3.3 -0.7 3.0 1.9
Arm predicted mass (left) 0.4 2.2 4.8 -2.2 -0.7 1.9 -0.0