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chr14:74,424,938-76,239,834

Best TWAS P=9.67e-14 · Best GWAS P=1.18e-13 conditioned to 0.00479

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DLST	0.09	0.11	lasso	2	0.11	4.0e-13	-6.8	7.2	7.1e-13	-0.74	0.08	0.92	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RPS6KL1	0.04	0.02	lasso	5	0.02	4.8e-04	5.8	-6.9	5.0e-12	0.62	0.14	0.61	FALSE
3	GTEx	Adipose Subcutaneous	YLPM1	0.10	0.03	lasso	6	0.02	7.9e-03	-6.2	6.4	1.6e-10	-0.59	0.09	0.39	FALSE
4	GTEx	Adipose Subcutaneous	RPS6KL1	0.09	0.12	lasso	3	0.10	2.5e-08	5.8	6.0	1.5e-09	-0.62	0.92	0.08	FALSE
5	GTEx	Adipose Visceral Omentum	RPS6KL1	0.12	0.09	lasso	2	0.08	3.7e-05	5.5	5.6	1.8e-08	-0.48	0.63	0.28	FALSE
6	GTEx	Adrenal Gland	RPS6KL1	0.21	0.13	enet	25	0.15	4.4e-06	6.0	5.8	5.1e-09	-0.58	0.35	0.56	FALSE
7	GTEx	Cells Transformed fibroblasts	RPS6KL1	0.16	0.15	enet	12	0.15	2.8e-11	5.5	5.6	2.2e-08	-0.64	0.97	0.03	FALSE
8	GTEx	Colon Sigmoid	MLH3	0.17	0.02	enet	9	0.00	2.4e-01	-1.8	-5.8	7.8e-09	0.23	0.09	0.15	FALSE
9	GTEx	Esophagus Mucosa	RPS6KL1	0.18	0.12	lasso	5	0.12	3.3e-08	-4.7	5.3	1.2e-07	-0.19	0.98	0.01	FALSE
10	GTEx	Esophagus Muscularis	RPS6KL1	0.10	0.11	lasso	2	0.09	3.1e-06	6.0	5.9	4.5e-09	-0.63	0.72	0.25	FALSE
11	GTEx	Lung	RPS6KL1	0.09	0.09	enet	24	0.08	1.8e-06	5.8	5.8	8.8e-09	-0.61	0.56	0.42	FALSE
12	GTEx	Muscle Skeletal	DLST	0.28	0.26	enet	23	0.26	2.1e-25	-6.4	-6.8	1.2e-11	0.34	0.83	0.17	FALSE
13	GTEx	Nerve Tibial	YLPM1	0.08	0.06	lasso	1	0.04	5.1e-04	6.3	6.3	2.9e-10	-0.68	0.11	0.65	FALSE
14	GTEx	Nerve Tibial	RPS6KL1	0.17	0.24	lasso	6	0.19	2.3e-13	5.8	6.2	6.3e-10	-0.59	0.99	0.01	FALSE
15	GTEx	Pancreas	ZC2HC1C	0.16	0.01	enet	31	0.04	1.1e-02	-4.4	-5.3	1.4e-07	0.43	0.53	0.28	FALSE
16	GTEx	Prostate	RPS6KL1	0.26	0.10	lasso	3	0.17	4.6e-05	6.3	5.2	2.1e-07	-0.66	0.08	0.79	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	RPS6KL1	0.08	0.08	enet	11	0.07	1.5e-04	6.7	7.5	9.7e-14	-0.74	0.08	0.90	TRUE
18	GTEx	Skin Sun Exposed Lower leg	RPS6KL1	0.15	0.13	lasso	4	0.12	1.8e-10	5.5	6.0	2.1e-09	-0.69	0.88	0.12	FALSE
19	GTEx	Testis	AREL1	0.20	0.14	enet	34	0.13	2.1e-06	7.1	7.4	1.4e-13	-0.78	0.04	0.96	FALSE
20	GTEx	Thyroid	RPS6KL1	0.23	0.14	enet	14	0.14	1.3e-10	6.0	5.8	7.5e-09	-0.60	0.99	0.01	FALSE
21	METSIM	Adipose	ACYP1	0.03	0.02	blup	413	0.02	4.0e-04	-2.9	5.7	1.6e-08	-0.52	0.86	0.05	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPS6KL1	0.03	0.02	lasso	3	0.02	8.5e-06	7.2	7.2	6.7e-13	-0.78	0.00	1.00	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RPS6KL1	0.04	0.04	lasso	3	0.03	1.8e-04	7.2	7.2	6.0e-13	-0.77	0.00	0.99	FALSE
24	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RPS6KL1	0.09	0.10	blup	49	0.11	5.1e-07	-4.5	6.1	9.7e-10	-0.39	0.89	0.07	FALSE
25	The Cancer Genome Atlas	Lung Adenocarcinoma	RPS6KL1	0.03	0.01	blup	49	0.02	2.3e-03	6.3	6.7	2.2e-11	-0.55	0.02	0.59	FALSE
26	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RPS6KL1	0.02	0.02	lasso	2	0.02	5.6e-03	6.0	6.0	2.1e-09	-0.61	0.04	0.22	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	RPS6KL1	0.09	0.04	enet	6	0.06	1.1e-06	5.8	5.7	1.5e-08	-0.55	0.27	0.73	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	RPS6KL1	0.20	0.17	lasso	2	0.17	5.3e-16	5.5	5.6	2.2e-08	-0.61	0.99	0.01	FALSE