Hub : Genes

ZC2HC1C

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.147	0.071	6.7e-03	0.046	NA	-0.005	NA	0.046	1.8e-02	NA	4.8e-01	NA	1.8e-02
2	GTEx	Brain Putamen basal ganglia	0.204	0.079	2.1e-04	0.184	NA	0.083	NA	0.162	3.9e-05	NA	5.4e-03	NA	1.2e-04
3	GTEx	Pancreas	0.158	0.057	4.3e-05	0.006	NA	0.037	NA	0.024	1.7e-01	NA	1.1e-02	NA	3.3e-02
4	GTEx	Testis	0.367	0.070	8.3e-15	0.356	NA	0.293	NA	0.098	1.2e-16	NA	1.8e-13	NA	4.1e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.7	1.1	1.6	-1.2	-1.0	0.6	-1.3
Bipolar Disorder or Schizophrenia	0.9	2.2	3.9	-2.0	-1.5	0.2	-1.6
Depressed Affect (Nagel 2018)	4.8	10.1	12.1	3.1	2.8	-3.5	3.4
Depression (Nagel 2018)	0.2	0.4	0.6	0.7	0.6	-0.2	0.8
Intelligence (Savage-Jansen 2018)	1.0	3.1	4.5	-1.9	-2.1	1.0	-1.9
Neuroticism (Nagel 2018)	6.1	14.4	21.0	3.2	3.3	-4.6	3.9
Schizophrenia (2018)	0.6	1.3	2.4	-1.6	-1.2	-0.3	-1.1
Schizophrenia vs Biploar Disorder	0.2	0.2	0.6	0.2	0.2	-0.8	0.3
Worry (Nagel 2018)	7.1	14.9	27.8	2.8	3.2	-5.3	3.7
Alzheimer’s Disease (in mother)	0.8	1.0	3.5	-0.0	-0.2	1.9	-0.6
Alzheimer’s Disease (in father)	0.1	0.2	0.5	-0.0	0.3	-0.7	-0.1
Alzheimer’s Disease (including proxy)	0.4	0.6	2.0	-0.1	-0.2	1.4	-0.4
Crohns Disease (2017)	0.3	0.6	0.9	0.8	0.7	-0.9	0.7
Irritable Bowel Disease (IBD)	0.5	1.2	1.5	-1.0	-1.2	1.0	-1.2
Ulcerative Colitis (UC)	2.6	4.9	5.6	-2.1	-2.4	2.1	-2.3
Major Depression (MDD)	0.5	0.6	1.9	0.3	0.5	-1.4	0.3
Reaction Time	2.5	4.8	6.2	-2.4	-2.2	1.5	-2.5
Verbal and Numeric Reasoning (VNR)	1.5	3.5	4.3	-1.9	-2.0	1.5	-2.1
Breast Cancer	0.4	0.9	1.6	1.2	1.3	-0.2	0.9
Ovarian Cancer	1.9	2.6	3.4	1.7	1.5	-1.9	1.2
Prostate Cancer	1.5	2.1	3.1	0.9	1.5	-1.8	1.5
Age at First Birth	2.9	4.2	5.7	2.2	2.1	-1.5	2.4
Bipolar Disorder (2011)	0.8	0.8	1.5	0.0	-0.9	0.8	-1.2
Body Mass Index (BMI) (2010)	0.2	0.2	0.9	0.1	0.3	-0.9	0.1
Coronary Artery Disease (CAD)	7.5	9.0	9.8	3.0	3.0	-2.9	3.1
Crohns Disease (2012)	0.7	1.2	1.7	1.3	0.8	-1.1	1.1
Mean Putamen Volume	0.2	0.2	0.5	0.1	-0.4	0.7	-0.3
Fasting Glucose	0.2	0.2	0.4	-0.1	-0.2	0.6	-0.6
HbA1C	0.4	0.4	0.9	-0.7	-0.5	-0.1	-0.9
HDL Cholesterol	0.1	0.2	0.3	-0.4	-0.3	0.5	-0.3
LDL Cholesterol	0.7	1.0	2.3	-1.0	-0.7	1.5	-0.6
Lupus	2.1	3.2	4.8	1.9	1.9	-0.8	2.2
Neuroticism (2016)	0.9	1.4	4.0	0.6	0.7	-2.0	0.8
Primary Biliary Cirrhosis	1.1	1.5	2.0	1.2	1.1	-1.2	1.4
Rheumatoid Arthritis	6.1	8.5	9.2	-3.0	-2.9	2.9	-2.8
Schizophrenia (2014)	0.5	1.0	2.8	-1.1	-0.2	-1.7	-0.2
Triglycerides	1.3	2.1	3.3	1.4	1.7	-0.7	1.8
Type 2 Diabetes (T2D) (2012)	2.9	3.3	4.7	-1.9	-2.0	1.0	-2.2
Ulcerative Colitis	0.4	0.5	1.1	-0.3	-0.6	1.1	-0.7
Blood Eosinophil Count	0.3	2.1	7.3	-0.3	-0.9	2.7	-0.5
Blood Platelet Count	1.7	19.3	22.9	-4.0	-4.3	4.8	-4.4
Blood Red Count	0.3	3.2	5.3	-2.3	-1.6	1.7	-1.4
Blood White Count	0.5	4.0	9.7	-0.8	-1.7	3.1	-1.7
Heel T-Score	7.3	58.1	61.0	7.8	7.7	-7.8	7.3
BMI	0.2	1.4	2.2	-0.9	-1.5	1.1	-1.3
Height	1.8	33.8	37.1	-5.8	-6.1	5.6	-5.8
Waist Hip Ratio (WHR)	0.1	0.5	1.4	-1.2	-0.6	-0.0	-0.6
Systolic Blood Pressure	5.8	28.8	31.6	5.6	5.4	-5.3	5.0
Smoking Status	0.1	0.2	0.5	-0.2	-0.6	-0.7	0.1
Allergy or Eczema	0.7	1.7	2.9	-1.1	-1.3	1.1	-1.7
Cardiovascular Disease	1.4	4.6	5.0	2.2	2.2	-2.2	2.0
Hypothyroidism (self reported)	5.1	11.8	12.8	3.4	3.6	-3.2	3.5
Respiratory disease	0.1	0.2	0.7	-0.4	-0.0	-0.9	0.2
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.2	-0.3	0.5	-0.2	0.1
Lung FEV1/FVC ratio	0.3	1.4	4.3	-0.3	-0.7	2.1	-1.0
Lung FVC	0.7	3.7	6.6	-2.6	-1.8	1.2	-1.9
Neuroticism	4.5	10.8	17.1	2.5	2.8	-4.1	3.4
Chronotype (morning person)	0.1	0.2	0.6	0.7	0.4	-0.3	0.4
Hair Pigment	0.1	2.4	3.8	2.0	1.5	-0.9	1.6
Tanning	0.1	1.5	3.5	-0.5	-1.0	1.9	-1.2
Hand grip strength (left)	1.7	4.6	9.0	1.8	1.9	-3.0	1.6
Number of treatments/medications taken	4.7	8.5	16.6	2.3	2.2	-4.1	2.6
Average weekly spirits intake	7.1	8.8	11.3	-3.1	-3.1	2.2	-3.4
Sensitivity / hurt feelings	1.2	2.1	2.7	1.6	1.1	-1.4	1.6
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.7	0.8	0.7	-0.6	0.8
Hearing difficulty/problems: Yes	5.1	7.7	10.8	-3.2	-3.3	0.9	-3.1
Relative age of first facial hair	0.5	1.0	1.6	-1.3	-1.1	-0.6	-0.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	2.5	0.1	-0.1	-1.6	0.2
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.7	0.1	-0.0	-1.3	0.6
Ever had hysterectomy (womb removed)	0.2	0.2	0.5	-0.3	-0.4	-0.7	-0.0
Systolic blood pressure, automated reading	3.7	10.7	17.2	2.9	3.0	-4.1	2.9
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.2	0.2	0.0	0.4
Angina	3.1	4.1	5.4	2.2	1.8	-2.3	1.7
Medication for hormone replacement therapy	0.5	0.5	0.9	0.6	0.6	-1.0	0.7
Vitamin and mineral supplements	0.2	0.3	0.7	0.5	0.5	-0.0	0.9
Supplements: Zinc	0.6	0.6	0.9	-0.9	-1.0	-0.0	-0.9
Medication: Co-codamol	0.9	1.0	1.6	0.7	1.1	-1.0	1.3
Medication: Metformin	0.6	0.9	1.7	0.5	1.0	-0.8	1.3
Diabetes (father)	0.3	0.4	0.6	-0.8	-0.7	0.1	-0.7
Diabetes (mother)	0.1	0.1	0.1	-0.1	-0.3	0.4	-0.2
Severe depression (siblings)	1.1	1.2	2.0	0.9	1.4	-0.9	1.2
Pack years adult smoking proportion	0.4	0.7	1.3	-0.9	-0.6	1.1	-0.4
Impedance of leg (right)	2.8	13.5	15.6	3.3	3.6	-3.8	4.0
Leg fat-free mass (left)	3.0	15.9	20.0	-3.3	-4.0	4.5	-4.1
Trunk fat percentage	0.1	0.3	0.7	-0.1	-0.8	-0.5	-0.5
Hand grip strength (right)	1.0	2.7	5.0	1.5	1.5	-2.2	1.1
Townsend deprivation index at recruitment	0.4	0.6	1.8	0.2	0.1	-1.4	0.7
Current tobacco smoking	0.1	0.1	0.3	-0.0	-0.5	0.3	-0.1
Average weekly fortified wine intake	1.3	1.5	1.9	1.4	1.4	-1.0	1.1
Maternal smoking around birth	0.0	0.1	0.1	0.3	-0.2	-0.2	0.1
Fed-up feelings	7.5	13.5	18.1	3.4	3.3	-4.2	3.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.5	0.7	0.7	0.0	0.6
Relative age voice broke	0.2	0.3	0.5	-0.7	-0.5	-0.5	-0.5
Taking other prescription medications	4.5	6.9	14.0	1.9	2.0	-3.7	2.4
Age when periods started (menarche)	0.5	1.3	2.1	1.1	1.0	-0.8	1.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.7	-0.3	-0.7	-1.3	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	4.7	10.8	13.1	3.6	3.2	-3.1	3.1
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.3	0.4	-0.4	0.2
Qualifications: CSEs or equivalent	0.0	0.0	0.1	0.1	-0.3	0.3	-0.1
Serious illness, injury or assault to yourself	1.0	1.2	2.0	-1.1	-1.2	0.0	-1.4
High blood pressure	0.2	0.6	2.1	0.5	0.2	-1.5	0.3
Hayfever, allergic rhinitis or eczema	1.4	3.0	4.7	-1.4	-1.6	1.7	-2.2
Multivitamins +/- minerals	0.2	0.2	0.5	0.5	0.2	-0.7	-0.2
Stomach or abdominal pain in last month	0.1	0.2	0.4	0.0	-0.4	-0.6	0.3
Supplements: Glucosamine	0.3	0.4	0.8	0.9	0.5	-0.5	0.5
Diverticular disease/diverticulitis (self-reported)	3.5	4.2	5.2	-2.1	-2.3	1.8	-1.9
Medication: Atenolol	4.1	5.2	6.0	2.5	1.9	-2.4	2.3
Medication: Levothyroxine sodium	4.2	7.1	8.0	2.8	2.6	-2.7	2.5
Sitting height	0.0	0.2	0.6	-0.2	-0.1	0.8	-0.5
Chronic bronchitis/emphysema (father)	0.2	0.2	0.6	0.1	-0.4	0.8	0.0
High blood pressure (mother)	0.1	0.2	0.3	-0.1	0.5	-0.3	0.5
Body mass index (BMI)	0.1	0.6	1.5	-0.6	-1.2	0.2	-0.8
Impedance of leg (left)	3.3	16.2	19.6	3.5	3.9	-4.4	4.2
Leg predicted mass (left)	3.0	15.6	20.2	-3.3	-3.9	4.5	-4.0
Trunk fat mass	0.5	2.1	3.8	-1.2	-1.9	0.8	-1.6
Waist circumference	1.1	3.9	5.5	-1.9	-2.3	1.6	-1.9
Number of incorrect matches in round	0.5	0.8	2.2	0.4	0.7	-1.5	0.5
Past tobacco smoking	0.8	1.4	3.6	-0.7	-0.5	1.9	-1.1
Alcohol usually taken with meals	3.3	5.3	6.2	-2.4	-2.5	1.7	-2.5
Nervous feelings	5.2	9.7	15.7	2.4	2.9	-4.0	3.0
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	0.1	0.2	-0.7	0.4
Hearing difficulty/problems with background noise	2.0	3.2	5.1	-1.9	-2.3	-0.0	-2.0
Hair/balding pattern: Pattern 2	0.2	0.2	0.7	-0.1	-0.9	0.2	0.3
Had menopause	0.1	0.1	0.2	-0.5	-0.4	-0.4	0.0
Had other major operations	1.2	1.5	2.3	-1.5	-1.3	0.5	-1.3
Forced vital capacity (FVC)	2.2	8.5	12.4	-2.9	-2.5	3.5	-2.7
Heel bone mineral density (BMD) T-score, automated (right)	4.1	9.3	10.0	3.2	3.1	-3.2	2.8
Ever unenthusiastic/disinterested for a whole week	3.3	4.1	5.2	2.3	1.8	-1.9	2.1
Qualifications: None of the above	0.2	0.3	0.7	0.4	0.3	-0.9	0.6
Financial difficulties in last 2 years	2.1	2.8	4.7	-1.6	-2.2	0.8	-1.8
Mouth/teeth dental problems	0.2	0.4	0.4	0.7	0.6	-0.4	0.7
Heart attack	1.8	2.2	3.6	1.2	1.3	-1.9	1.5
Allergy	1.8	4.2	5.7	2.0	2.0	-1.8	2.4
Pain all over the body in last month	0.8	0.8	1.1	-0.9	-1.1	0.7	-0.9
Diabetes (self-reported)	0.7	1.1	1.7	0.3	1.2	-1.3	1.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.3	-0.3	-0.5	1.5	-0.6
Medication: Ramipril	1.6	2.1	4.9	0.9	1.2	-2.2	1.1
Medication: Simvastatin	1.9	2.8	5.9	1.1	1.3	-2.4	1.6
Fluid intelligence score	0.1	0.3	0.4	-0.4	-0.5	0.4	-0.7
Illnesses of siblings	0.3	0.4	1.4	-0.4	-0.1	1.2	-0.3
Neuroticism score	3.6	7.6	13.9	2.1	2.2	-3.7	2.7
Weight	1.4	6.9	9.0	-2.3	-3.0	2.4	-2.7
Impedance of arm (right)	0.0	0.2	0.5	0.1	-0.2	0.7	-0.3
Arm fat percentage (right)	0.5	1.8	3.4	-1.0	-1.8	0.8	-1.5
Trunk fat-free mass	2.3	13.1	16.5	-3.2	-3.7	4.1	-3.4
Hip circumference	1.7	7.1	10.2	-2.2	-3.2	2.5	-2.6
Time employed in main current job	1.4	1.6	4.3	0.5	1.0	-2.1	1.0
Alcohol intake versus 10 years previously	1.7	2.6	5.0	-1.6	-2.2	0.8	-1.5
Father’s age at death	2.2	2.9	3.9	-2.0	-1.9	1.2	-1.6
Worrier / anxious feelings	1.8	3.3	6.2	1.4	1.5	-2.5	1.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.5	-0.9	-1.2	0.1	-0.6
Falls in the last year	2.4	3.2	3.8	-1.9	-2.0	1.5	-1.8
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	-0.6	0.1	-0.9	-0.3
Number of live births	0.3	0.4	1.4	-0.0	-0.3	1.2	-0.5
Forced expiratory volume in 1-second (FEV1)	2.1	7.1	12.4	-2.4	-2.1	3.5	-2.4
Pulse rate	0.1	0.2	0.4	-0.6	-0.4	0.4	-0.5
Happiness	0.7	0.8	2.0	0.6	0.5	-1.4	0.8
Noisy workplace	0.2	0.2	0.7	-0.1	-0.2	-0.8	0.3
Qualifications: A levels/AS levels or equivalent	1.0	2.1	4.3	-1.3	-0.8	2.1	-1.3
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.0	2.9	-1.1	-1.7	1.2	-1.5
Mouth/teeth dental problems: Dentures	0.1	0.2	0.4	-0.3	-0.6	0.4	-0.6
Asthma	0.0	0.1	0.2	-0.3	0.1	-0.1	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.4	-0.4	-0.6	0.2	-0.6
Medication: Cholesterol lowering	1.0	1.5	3.8	0.7	1.0	-2.0	0.8
Depression (self-reported)	0.1	0.1	0.2	0.0	-0.4	-0.3	0.0
Medication: Lansoprazole	0.3	0.3	0.8	0.3	0.6	-0.3	0.9
Prospective memory result	0.4	0.5	0.6	-0.7	-0.7	-0.7	-0.6
Lung cancer (father)	0.0	0.0	0.1	0.2	0.2	0.1	0.1
Illnesses of mother	1.6	2.0	2.4	-1.5	-1.3	1.2	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.3	11.2	-2.2	-2.0	3.3	-2.2
Pulse wave Arterial Stiffness index	0.7	0.8	2.6	-0.4	-0.1	1.6	-0.8
Impedance of arm (left)	0.0	0.0	0.1	0.3	0.3	0.1	-0.0
Arm fat mass (right)	0.5	2.1	3.6	-1.2	-1.9	1.0	-1.5
Trunk predicted mass	2.3	13.0	16.3	-3.3	-3.6	4.0	-3.4
Standing height	2.0	19.4	24.5	-4.0	-4.3	4.9	-4.3
Length of working week for main job	0.4	0.4	0.7	0.7	0.8	0.3	0.6
Exposure to tobacco smoke at home	0.6	0.7	1.2	-1.0	-1.1	0.1	-0.8
Breastfed as a baby	0.8	1.0	1.3	-1.0	-0.8	1.0	-1.1
Tense / ‘highly strung’	0.4	0.7	2.4	0.1	0.5	-1.5	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	3.0	0.4	0.1	-1.7	0.6
Hair/balding pattern: Pattern 4	0.8	2.0	4.1	-0.6	-1.2	2.0	-1.5
Birth weight of first child	2.2	4.0	5.5	-2.3	-2.0	1.5	-2.1
Peak expiratory flow (PEF)	0.1	0.3	0.6	0.4	0.7	0.2	0.7
Pulse wave reflection index	0.8	1.0	2.2	-1.0	-0.7	1.5	-0.8
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.2	1.1	0.3	-0.4	0.5
Loud music exposure frequency	0.5	0.6	0.9	-0.5	-1.0	0.4	-1.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.8	-0.1	0.4	0.9	-0.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.7	0.3	0.8	-0.4	0.9
Blood clot in the leg (DVT)	1.5	2.0	3.2	-1.5	-1.5	0.4	-1.8
Medication: Paracetamol	0.8	1.4	1.6	1.3	1.1	-1.1	1.2
Headache pain in last month	0.4	0.7	1.5	0.5	0.7	-1.2	0.9
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.7	-0.6	-0.7	1.9	-0.8
Glaucoma (self-reported)	1.0	1.2	2.6	-1.6	-0.9	-0.8	-0.9
Gout (self-reported)	1.4	1.9	2.3	1.5	1.3	-1.1	1.5
Hypothyroidism/myxoedema (self-reported)	3.9	7.7	8.2	2.7	2.8	-2.9	2.8
Medication: Amlodipine	6.6	9.3	10.5	3.2	3.2	-2.6	3.1
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.4	0.5	0.4	1.2	0.7
Birth weight	0.1	0.2	0.3	0.5	0.5	0.0	0.5
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.4	0.0	-0.2	-1.5	0.6
High blood pressure (siblings)	0.3	0.4	0.6	0.7	0.5	-0.5	0.8
Forced vital capacity (FVC), Best measure	2.4	8.8	12.7	-2.9	-2.6	3.6	-2.7
Body fat percentage	0.1	0.3	1.0	0.3	-0.4	-1.0	0.0
Leg fat percentage (right)	0.7	2.4	4.9	1.4	0.8	-2.2	1.5
Arm fat-free mass (right)	1.0	5.1	6.0	-1.9	-2.4	2.4	-2.2
Exposure to tobacco smoke outside home	0.2	0.3	1.1	-0.0	-0.0	-1.0	-0.0
Comparative body size at age 10	1.4	3.9	5.5	-1.8	-1.5	2.3	-2.1
Number of full brothers	0.3	0.4	1.1	-0.3	-0.5	-1.0	-0.1
Worry too long after embarrassment	0.1	0.2	0.4	0.4	0.3	0.3	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.6	-0.6	-0.8	-1.3	-0.4
Wheeze or whistling in the chest in last year	0.3	0.5	1.0	0.8	0.6	-0.3	1.0
Number of children fathered	3.0	3.4	8.9	1.2	1.2	-3.0	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.2	0.2	0.5	-1.5	0.6
Age at first live birth	0.3	0.6	1.7	-0.1	-0.6	1.3	-0.5
Pulse wave peak to peak time	0.6	0.7	2.3	0.4	0.1	-1.5	0.7
Health satisfaction	0.1	0.1	0.1	-0.4	-0.4	-0.3	-0.3
Shortness of breath walking on level ground	2.0	2.3	2.8	1.6	1.7	-1.1	1.7
Qualifications: College or University degree	0.7	2.3	4.5	-2.1	-1.3	0.2	-1.7
Eye problems/disorders: None of the above	1.9	2.2	4.1	1.4	1.0	-2.0	1.2
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.4	0.6	0.5	-0.4	0.7
Emphysema/chronic bronchitis	0.6	0.7	1.2	-0.9	-1.1	0.2	-0.9
Medication for pain relief, constipation, heartburn	1.2	2.0	4.0	-1.2	-0.9	2.0	-1.4
Neck or shoulder pain in last month	0.4	0.6	1.0	-1.0	-0.6	0.9	-0.5
Medication: Blood pressure	1.2	2.2	2.8	1.3	1.5	-1.7	1.4
Angina (self-reported)	2.6	3.4	4.6	2.1	1.6	-2.0	1.5
Migraine (self-reported)	1.5	1.8	2.6	1.2	1.4	-1.6	1.2
Medication: Ibuprofen	0.5	0.6	1.0	-0.7	-1.0	0.2	-0.9
Medication: Allopurinol	3.3	4.3	5.3	2.0	1.9	-2.3	2.1
Medication: Omeprazole	0.9	1.0	1.7	1.0	1.1	-0.5	1.3
Medication: Seretide 50 evohaler	0.2	0.2	0.5	0.3	0.4	0.1	0.7
Mean time to correctly identify matches	3.7	7.1	9.0	-3.0	-2.6	2.2	-2.8
Heart disease (mother)	6.3	7.6	9.9	3.2	2.8	-2.0	2.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	0.1	-0.1	0.2	-0.1
Whole body fat mass	0.3	1.4	2.8	-0.9	-1.7	0.5	-1.3
Leg fat mass (right)	0.1	0.5	1.2	-0.5	-1.1	0.0	-0.6
Arm predicted mass (right)	0.9	4.7	5.6	-2.0	-2.4	2.2	-2.1
Pulse rate, automated reading	0.2	0.7	2.8	0.1	0.2	-1.7	0.3
Alcohol intake frequency.	1.3	3.1	4.2	-1.7	-1.9	1.2	-2.1
Comparative height size at age 10	3.6	19.9	22.9	-4.1	-4.3	4.8	-4.6
Number of full sisters	0.6	0.7	2.7	0.4	0.2	-1.6	0.1
Suffer from ‘nerves’	4.9	7.6	13.5	2.0	2.4	-3.7	2.7
Overall health rating	0.1	0.2	0.5	-0.3	-0.7	-0.3	-0.3
Chest pain or discomfort	0.4	0.5	2.1	0.1	-0.2	1.4	-0.3
Had major operations	0.3	0.3	0.5	0.6	0.6	-0.3	0.7
Age at last live birth	1.8	2.7	3.4	-1.2	-1.8	1.7	-1.8
Family relationship satisfaction	1.0	1.2	1.3	1.1	1.1	-1.1	1.1
Leg pain on walking	0.1	0.1	0.3	0.3	0.6	-0.0	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.2	0.4	0.1	-1.5	0.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.8	-0.7	-0.7	1.3	-0.8
Illness, injury, bereavement, stress in last 2 years	7.1	8.7	12.0	3.1	3.5	-1.5	3.4
Medication: Aspirin	3.0	4.0	4.6	2.0	1.7	-2.2	2.1
Supplements: Vitamin C	2.7	3.2	3.5	-1.6	-1.8	1.8	-1.9
Knee pain experienced in last month	0.8	1.3	1.9	-1.1	-1.1	1.4	-0.8
Hypertension (Self-reported)	0.6	1.6	3.8	1.1	0.8	-1.9	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.6	5.4	8.7	2.1	2.3	-1.7	2.9
Illnesses of father: Heart disease	1.0	1.4	2.3	1.2	1.5	-0.4	1.4
Illnesses of siblings: Diabetes	0.1	0.2	0.5	0.3	0.1	-0.7	0.2
Smoking status: Previous	1.0	1.4	3.3	0.7	0.8	-1.8	1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	3.8	-1.7	-1.3	1.9	-1.9
Whole body fat-free mass	2.4	13.7	17.0	-3.2	-3.8	4.1	-3.6
Leg fat-free mass (right)	3.2	16.9	20.7	-3.5	-4.1	4.6	-4.2
Arm fat percentage (left)	0.3	1.2	2.3	-0.9	-1.5	0.4	-1.3
Average weekly red wine intake	1.1	1.6	2.9	-1.2	-0.9	1.7	-1.2
Handedness (chirality/laterality): Left-handed	2.5	3.0	3.8	-2.0	-1.4	1.6	-1.9
Mood swings	2.9	5.3	6.9	2.2	1.9	-2.6	2.4
Loneliness, isolation	0.4	0.6	1.2	0.4	0.7	-1.1	0.8
Long-standing illness, disability or infirmity	0.1	0.2	0.9	0.2	-0.1	-0.9	0.0
Ever had bowel cancer screening	0.1	0.2	0.4	-0.5	-0.1	-0.6	-0.1
Diabetes diagnosed by doctor	0.2	0.3	0.5	-0.1	0.7	-0.6	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	0.9	0.9	0.8	-1.0	0.4
Friendships satisfaction	0.3	0.4	0.5	-0.5	-0.6	-0.7	-0.7
Qualifications: nursing, teaching	1.2	1.9	3.7	-1.3	-1.0	1.9	-1.1
Commuting to job workplace: Walk	0.8	0.8	1.0	1.0	0.9	-0.9	0.8
Eye problems/disorders: Cataract	3.5	4.1	5.8	-2.0	-1.7	2.4	-1.9
Mouth/teeth dental problems: Mouth ulcers	6.2	9.9	12.3	-3.1	-3.5	2.6	-3.4
Medication for cholesterol	2.7	4.1	6.1	-1.7	-1.6	2.5	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.5	-0.3	-0.7	0.6	-0.2
Back pain experienced in last month	2.0	2.9	4.0	1.6	1.4	-1.7	2.0
Mineral and other dietary supplements	0.7	1.0	1.4	0.9	1.1	0.7	1.2
Breast cancer (self-reported)	0.3	0.4	1.0	-1.0	-0.5	-0.0	-0.5
Asthma (self-reported)	0.0	0.1	0.2	-0.4	0.0	-0.1	0.3
Osteoporosis (self-reported)	1.4	1.7	2.8	-1.7	-1.3	0.8	-1.3
Osteoarthritis (self-reported)	0.3	0.3	0.6	-0.4	-0.8	0.7	-0.4
Medication: Aspirin	1.7	2.2	2.7	1.5	1.0	-1.7	1.6
Medication: Gliclazide	0.2	0.2	0.9	-0.1	0.1	-0.9	0.3
Illnesses of father: None of the above (group 1)	2.3	2.8	4.3	-2.1	-1.7	1.0	-1.8
Smoking status: Current	0.1	0.2	0.5	-0.2	-0.7	0.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.6	-0.0	0.0	0.8	-0.3
Whole body water mass	2.3	13.0	16.3	-3.1	-3.7	4.0	-3.6
Leg predicted mass (right)	3.2	17.3	21.1	-3.6	-4.2	4.6	-4.3
Arm fat mass (left)	0.6	2.5	4.3	-1.3	-2.1	1.1	-1.7
Number of self-reported non-cancer illnesses	0.3	0.4	1.7	-0.2	0.1	-1.3	0.3
Average weekly champagne plus white wine intake	1.5	2.1	2.6	1.4	1.6	-1.2	1.5
Miserableness	1.1	1.9	2.7	1.7	1.1	-1.2	1.6
Guilty feelings	3.5	5.3	7.0	1.9	2.3	-2.6	2.3
Wears glasses or contact lenses	0.8	1.0	3.4	0.5	-0.3	-1.8	0.4
Ever taken oral contraceptive pill	1.7	1.9	2.5	1.6	1.1	-1.3	1.5
Hearing aid user	7.0	8.0	11.0	-3.2	-3.3	1.5	-2.9
Mother’s age at death	0.9	1.1	1.5	-1.2	-1.0	0.9	-1.0
Financial situation satisfaction	0.4	0.5	1.7	0.3	-0.2	-1.3	0.3
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.7	-0.8	-0.5	0.2	-0.8
Commuting to job workplace: Public transport	0.7	0.8	1.2	-0.9	-1.1	0.5	-1.0
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	-0.3	0.2	-0.8	0.1
Medication: Blood pressure	2.6	5.0	9.6	1.8	1.6	-3.1	2.1
Pain type(s) experienced in last month: Hip pain	1.4	1.7	2.4	1.2	0.9	-1.5	1.5
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.6	-0.5	-0.7	-0.5	-0.8
High cholesterol (Self-reported)	0.2	0.3	0.9	0.1	0.3	-1.0	0.5
Medication: Bendroflumethiazide	0.6	0.9	1.1	0.9	1.0	-0.9	1.0
Medication: Paracetamol	1.3	2.0	2.4	1.5	1.4	-1.2	1.4
Medication: Lisinopril	0.5	0.7	1.0	0.9	1.0	-0.7	0.8
Medication: Atorvastatin	0.7	0.8	1.3	1.1	0.8	-0.8	0.9
Illnesses of father: High blood pressure	2.9	3.6	4.4	1.9	2.0	-1.6	2.1
Alcohol drinker status: Never	0.1	0.2	0.3	-0.3	-0.5	0.3	-0.6
Ever smoked	0.5	1.0	1.5	0.8	0.6	-1.1	1.2
Basal metabolic rate	2.2	12.0	14.2	-3.0	-3.6	3.8	-3.5
Leg fat percentage (left)	0.8	2.7	6.2	1.4	0.9	-2.5	1.5
Arm fat-free mass (left)	1.2	6.3	7.6	-2.1	-2.7	2.8	-2.4
Number of operations (self-reported)	0.6	0.8	2.1	-1.4	-0.9	-0.5	-0.5
Average weekly beer plus cider intake	1.7	2.5	3.3	1.8	1.3	-1.6	1.5
Irritability	0.7	1.1	4.0	0.1	0.4	-2.0	0.6
Risk taking	0.3	0.4	0.5	0.5	0.7	-0.5	0.7
Ever had prostate specific antigen (PSA) test	1.8	2.0	2.9	-1.6	-1.4	0.8	-1.7
Fractured/broken bones in last 5 years	3.2	4.2	5.6	-2.2	-2.1	1.4	-2.4
Age started oral contraceptive pill	2.8	3.4	5.0	-2.2	-2.0	1.1	-1.9
Diastolic blood pressure, automated reading	0.9	2.9	5.2	1.4	1.5	-2.3	1.4
Ever depressed for a whole week	1.4	1.7	2.4	1.6	1.4	-0.6	1.4
Unable to work because of sickness or disability	1.6	2.0	2.5	-1.6	-1.3	1.4	-1.4
Commuting to job workplace: Cycle	2.0	2.5	3.7	1.6	1.9	-0.7	1.7
Myopia	1.0	1.4	2.0	1.0	1.0	-1.4	1.3
Vascular/heart problems diagnosed by doctor	0.4	1.2	3.3	-0.8	-0.5	1.8	-0.6
Cholesterol lowering medication	0.1	0.1	0.2	-0.3	-0.5	-0.3	0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	0.1	0.2	0.5	0.3
Pain experienced in last month	0.1	0.2	0.4	0.4	0.5	0.6	-0.1
Supplements: Calcium	0.3	0.4	1.3	-0.4	0.2	-1.1	-0.0
Basal cell carcinoma (self-reported)	1.0	1.2	2.0	-0.7	-1.0	1.4	-1.2
Heart attack/myocardial infarction (self-reported)	1.8	2.3	3.2	1.3	1.4	-1.8	1.5
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.2	-1.1	-1.2	0.2	-1.5
Heart disease (siblings)	1.6	2.0	3.3	1.8	1.3	-1.2	1.3
Alcohol drinker status: Previous	0.3	0.3	0.6	0.8	0.4	-0.6	0.4
Pack years of smoking	0.7	1.1	1.7	-1.3	-0.9	1.1	-0.7
Impedance of whole body	0.9	4.5	5.0	2.0	2.2	-2.0	2.2
Leg fat mass (left)	0.2	0.6	1.5	-0.6	-1.2	0.0	-0.8
Arm predicted mass (left)	1.1	5.4	6.6	-1.9	-2.6	2.6	-2.2