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chr16:29,412,503-31,860,399

Best TWAS P=4.24e-11 · Best GWAS P=1.58e-08 conditioned to 0.205

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	HSD3B7	0.05	0.06	lasso	4	0.07	5.5e-09	-5.6	-5.6	2.3e-08	1.00	0.02	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PRSS36	0.14	0.09	enet	13	0.11	1.4e-13	-5.5	-5.4	6.9e-08	0.69	0.03	0.97	FALSE
3	GTEx	Adipose Subcutaneous	KAT8	0.19	0.17	lasso	5	0.25	4.8e-20	-5.6	-6.3	3.5e-10	0.88	0.01	0.99	FALSE
4	GTEx	Adipose Subcutaneous	RP11-196G11.2	0.23	0.20	lasso	9	0.21	4.2e-17	-5.3	-5.5	4.3e-08	0.96	0.07	0.93	FALSE
5	GTEx	Adipose Visceral Omentum	RP11-196G11.2	0.08	0.07	enet	16	0.08	8.4e-05	-5.6	-5.7	1.2e-08	0.92	0.04	0.95	FALSE
6	GTEx	Artery Aorta	STX1B	0.17	0.18	lasso	6	0.15	1.9e-08	-5.6	-5.6	2.5e-08	0.98	0.02	0.98	FALSE
7	GTEx	Artery Aorta	KAT8	0.23	0.20	lasso	4	0.20	2.7e-11	5.0	-5.8	5.2e-09	0.76	0.36	0.64	FALSE
8	GTEx	Artery Aorta	INO80E	0.12	0.17	enet	11	0.17	1.9e-09	5.3	5.2	1.7e-07	-0.12	0.02	0.98	FALSE
9	GTEx	Artery Aorta	RP11-196G11.2	0.10	0.16	lasso	2	0.14	7.1e-08	-5.2	-5.3	1.2e-07	0.95	0.05	0.95	FALSE
10	GTEx	Artery Coronary	RP11-196G11.2	0.12	0.06	lasso	6	0.06	3.4e-03	-5.3	-5.2	1.6e-07	0.93	0.05	0.87	FALSE
11	GTEx	Artery Tibial	KAT8	0.30	0.23	lasso	5	0.27	3.3e-21	-5.6	-5.8	5.6e-09	0.82	0.01	0.99	FALSE
12	GTEx	Brain Caudate basal ganglia	PRSS36	0.16	0.25	lasso	3	0.23	2.4e-07	-5.6	-5.6	2.6e-08	0.79	0.02	0.96	FALSE
13	GTEx	Brain Cerebellar Hemisphere	YPEL3	0.15	0.13	lasso	6	0.11	8.1e-04	-4.9	-5.2	2.3e-07	0.05	0.04	0.87	FALSE
14	GTEx	Brain Cerebellar Hemisphere	STX1B	0.13	0.11	lasso	5	0.10	1.5e-03	-5.4	-5.4	7.2e-08	0.93	0.04	0.69	FALSE
15	GTEx	Brain Cerebellar Hemisphere	RP11-196G11.2	0.18	0.06	lasso	6	0.10	1.7e-03	-5.6	-5.5	3.7e-08	0.97	0.03	0.87	FALSE
16	GTEx	Brain Cerebellum	STX4	0.14	0.25	lasso	1	0.24	8.3e-08	-5.3	-5.3	9.8e-08	0.94	0.06	0.93	FALSE
17	GTEx	Brain Cerebellum	KAT8	0.21	0.01	lasso	9	0.05	1.4e-02	5.0	-5.6	2.9e-08	0.79	0.06	0.76	FALSE
18	GTEx	Brain Cerebellum	RP11-196G11.2	0.31	0.30	lasso	4	0.36	1.3e-11	-5.3	-5.4	7.3e-08	0.96	0.06	0.94	FALSE
19	GTEx	Brain Frontal Cortex BA9	C16orf93	0.25	0.13	enet	16	0.23	8.3e-07	3.6	5.1	3.1e-07	-0.58	0.11	0.43	FALSE
20	GTEx	Brain Nucleus accumbens basal ganglia	KAT8	0.19	0.13	lasso	4	0.18	1.4e-05	4.9	-6.0	1.7e-09	0.79	0.05	0.66	FALSE
21	GTEx	Brain Nucleus accumbens basal ganglia	PRSS36	0.40	0.28	lasso	2	0.26	1.6e-07	-5.6	-5.6	1.9e-08	0.78	0.02	0.97	FALSE
22	GTEx	Breast Mammary Tissue	KAT8	0.23	0.14	lasso	10	0.17	4.4e-09	5.0	-6.5	7.3e-11	0.82	0.07	0.93	FALSE
23	GTEx	Breast Mammary Tissue (Male)	KAT8	0.13	0.01	enet	3	0.01	1.7e-01	-5.6	-6.6	4.2e-11	0.62	0.03	0.32	TRUE
24	GTEx	Breast Mammary Tissue (Male)	RP11-196G11.2	0.15	0.16	lasso	4	0.09	3.9e-03	-5.3	-5.3	1.4e-07	0.98	0.05	0.87	FALSE
25	GTEx	Breast Mammary Tissue (Female)	INO80E	0.20	0.13	lasso	7	0.06	7.3e-03	5.3	5.3	1.5e-07	-0.10	0.02	0.80	FALSE
26	GTEx	Cells Transformed fibroblasts	KAT8	0.31	0.31	lasso	4	0.32	1.9e-24	-5.6	-6.0	2.5e-09	0.81	0.01	0.99	FALSE
27	GTEx	Cells Transformed fibroblasts	RP11-196G11.2	0.14	0.14	lasso	6	0.13	2.9e-10	-5.6	-5.5	3.7e-08	0.98	0.02	0.98	FALSE
28	GTEx	Colon Sigmoid	KAT8	0.20	0.10	lasso	3	0.14	1.0e-05	5.0	-6.1	1.2e-09	0.80	0.08	0.74	FALSE
29	GTEx	Colon Transverse	STX4	0.10	0.09	lasso	3	0.06	6.6e-04	-5.3	-5.3	1.4e-07	0.98	0.04	0.90	FALSE
30	GTEx	Colon Transverse	KAT8	0.14	0.12	lasso	6	0.05	1.4e-03	-5.6	-5.9	4.9e-09	0.80	0.02	0.95	FALSE
31	GTEx	Colon Transverse	INO80E	0.14	0.17	enet	16	0.19	3.3e-09	5.3	5.3	1.2e-07	-0.11	0.01	0.99	FALSE
32	GTEx	Colon Transverse	RP11-196G11.2	0.24	0.11	lasso	5	0.15	1.9e-07	-5.2	-5.5	3.6e-08	0.94	0.04	0.96	FALSE
33	GTEx	Esophagus Gastroesophageal Junction	KAT8	0.18	0.11	lasso	4	0.24	4.9e-09	-5.6	-6.0	1.7e-09	0.88	0.04	0.96	FALSE
34	GTEx	Esophagus Mucosa	STX1B	0.12	0.03	lasso	5	0.05	1.7e-04	-5.5	-5.1	3.0e-07	0.86	0.05	0.94	FALSE
35	GTEx	Esophagus Mucosa	HSD3B7	0.38	0.32	lasso	5	0.36	1.2e-24	-5.3	-5.1	2.7e-07	0.93	0.09	0.91	FALSE
36	GTEx	Esophagus Mucosa	KAT8	0.21	0.15	lasso	4	0.23	3.5e-15	-5.6	-6.1	1.1e-09	0.82	0.02	0.98	FALSE
37	GTEx	Esophagus Mucosa	INO80E	0.12	0.16	enet	14	0.20	4.6e-13	5.3	5.2	2.6e-07	-0.10	0.01	0.99	FALSE
38	GTEx	Esophagus Mucosa	RP11-196G11.2	0.09	0.03	enet	13	0.05	1.5e-04	-5.3	-5.6	2.7e-08	0.91	0.04	0.94	FALSE
39	GTEx	Esophagus Muscularis	STX4	0.05	0.05	lasso	3	0.03	6.7e-03	-5.2	-5.4	6.2e-08	0.97	0.03	0.93	FALSE
40	GTEx	Esophagus Muscularis	KAT8	0.29	0.19	lasso	4	0.21	1.2e-12	-5.6	-6.1	8.2e-10	0.82	0.02	0.98	FALSE
41	GTEx	Esophagus Muscularis	RP11-196G11.2	0.14	0.14	lasso	6	0.13	3.7e-08	-5.3	-5.6	2.8e-08	0.96	0.03	0.97	FALSE
42	GTEx	Heart Atrial Appendage	INO80E	0.14	0.17	lasso	3	0.19	5.7e-09	-4.7	5.2	2.4e-07	-0.12	0.06	0.93	FALSE
43	GTEx	Heart Left Ventricle	HSD3B7	0.12	0.08	lasso	3	0.07	2.0e-04	-5.4	-5.3	1.2e-07	0.94	0.08	0.90	FALSE
44	GTEx	Liver	PRSS36	0.13	0.03	enet	34	0.04	2.2e-02	-3.8	-5.2	1.7e-07	0.68	0.05	0.56	FALSE
45	GTEx	Lung	KAT8	0.14	0.08	lasso	3	0.12	1.7e-09	5.0	-6.1	1.1e-09	0.77	0.04	0.96	FALSE
46	GTEx	Lung	INO80E	0.18	0.17	lasso	8	0.19	1.0e-14	5.3	5.3	1.3e-07	-0.10	0.01	0.99	FALSE
47	GTEx	Lung	RP11-196G11.2	0.21	0.12	enet	22	0.14	1.6e-10	-5.5	-5.8	8.1e-09	0.88	0.06	0.94	FALSE
48	GTEx	Muscle Skeletal	STX4	0.04	0.04	lasso	3	0.03	2.9e-04	-5.6	-5.6	2.6e-08	0.98	0.03	0.97	FALSE
49	GTEx	Muscle Skeletal	KAT8	0.08	0.04	enet	16	0.06	1.4e-06	-4.0	-5.4	6.0e-08	0.86	0.03	0.97	FALSE
50	GTEx	Nerve Tibial	HSD3B7	0.09	0.05	lasso	3	0.03	2.4e-03	-5.5	-5.3	9.7e-08	0.95	0.05	0.81	FALSE
51	GTEx	Nerve Tibial	RP11-196G11.2	0.17	0.22	lasso	6	0.22	2.3e-15	-5.2	-5.2	2.2e-07	0.96	0.04	0.96	FALSE
52	GTEx	Ovary	KAT8	0.16	0.09	lasso	4	0.06	1.2e-02	5.0	-5.8	6.3e-09	0.75	0.08	0.50	FALSE
53	GTEx	Ovary	INO80E	0.16	0.06	lasso	14	0.13	5.1e-04	-4.6	5.8	5.0e-09	-0.10	0.04	0.83	TRUE
54	GTEx	Pancreas	STX1B	0.23	0.18	lasso	3	0.16	2.8e-07	-5.3	-5.3	1.4e-07	0.98	0.06	0.94	FALSE
55	GTEx	Pancreas	RP11-196G11.2	0.13	0.11	lasso	1	0.11	2.5e-05	-5.2	-5.2	1.9e-07	0.95	0.05	0.93	FALSE
56	GTEx	Pituitary	HSD3B7	0.13	0.07	lasso	7	0.05	2.1e-02	-5.4	-5.5	4.6e-08	0.90	0.06	0.82	FALSE
57	GTEx	Pituitary	KAT8	0.18	0.10	lasso	3	0.13	4.4e-04	-5.6	-5.7	1.5e-08	0.79	0.02	0.95	FALSE
58	GTEx	Pituitary	C16orf93	0.10	0.00	enet	14	0.00	2.4e-01	-1.5	5.3	1.0e-07	-0.63	0.05	0.23	FALSE
59	GTEx	Skin Not Sun Exposed Suprapubic	KAT8	0.30	0.20	enet	15	0.26	1.9e-14	-5.6	-6.1	1.4e-09	0.83	0.02	0.98	FALSE
60	GTEx	Skin Sun Exposed Lower leg	STX1B	0.05	0.04	enet	4	0.05	7.2e-05	-5.3	-5.4	8.5e-08	0.97	0.06	0.93	FALSE
61	GTEx	Skin Sun Exposed Lower leg	HSD3B7	0.12	0.17	lasso	5	0.16	2.7e-13	-4.9	-5.2	1.7e-07	0.92	0.09	0.91	FALSE
62	GTEx	Skin Sun Exposed Lower leg	KAT8	0.31	0.23	lasso	6	0.35	2.2e-30	5.0	-6.2	7.5e-10	0.82	0.05	0.95	FALSE
63	GTEx	Skin Sun Exposed Lower leg	RP11-196G11.2	0.16	0.15	lasso	7	0.15	4.0e-12	-5.3	-5.3	1.5e-07	0.96	0.04	0.96	FALSE
64	GTEx	Stomach	KAT8	0.12	0.03	lasso	5	0.07	2.9e-04	-5.6	-5.3	9.8e-08	0.81	0.05	0.92	FALSE
65	GTEx	Stomach	INO80E	0.09	0.07	enet	6	0.02	3.4e-02	5.3	5.3	1.3e-07	-0.10	0.03	0.90	FALSE
66	GTEx	Testis	RP11-196G11.2	0.14	0.11	lasso	4	0.13	3.1e-06	-5.2	-5.4	8.2e-08	0.96	0.04	0.96	FALSE
67	GTEx	Thyroid	KAT8	0.21	0.12	lasso	6	0.15	2.2e-11	4.7	-5.6	2.2e-08	0.78	0.21	0.78	FALSE
68	GTEx	Thyroid	INO80E	0.15	0.25	lasso	3	0.25	2.0e-19	5.3	5.3	1.1e-07	-0.11	0.01	0.99	FALSE
69	GTEx	Thyroid	RP11-196G11.2	0.11	0.14	lasso	2	0.14	3.5e-11	-5.5	-5.5	4.2e-08	0.96	0.04	0.96	FALSE
70	GTEx	Uterus	RP11-196G11.2	0.18	0.16	lasso	20	0.15	5.4e-04	-5.3	-5.3	1.2e-07	0.95	0.07	0.88	FALSE
71	GTEx	Vagina	KAT8	0.34	0.26	lasso	5	0.22	8.4e-06	-5.6	-5.7	1.4e-08	0.79	0.02	0.88	FALSE
72	GTEx	Vagina	INO80E	0.24	0.23	lasso	6	0.27	7.0e-07	5.1	5.2	2.2e-07	-0.11	0.03	0.96	FALSE
73	GTEx	Whole Blood	ZNF668	0.05	0.06	lasso	3	0.06	5.9e-06	4.7	5.7	1.0e-08	-0.78	0.26	0.74	FALSE
74	METSIM	Adipose	KAT8	0.17	0.13	lasso	6	0.20	1.7e-28	4.7	-6.0	2.5e-09	0.79	0.06	0.94	FALSE
75	METSIM	Adipose	RP11-196G11.2	0.13	0.17	lasso	9	0.16	2.2e-23	-5.6	-5.5	3.1e-08	1.00	0.02	0.98	FALSE
76	METSIM	Adipose	YPEL3	0.16	0.21	enet	12	0.22	9.5e-33	-5.0	-5.1	3.0e-07	0.07	0.06	0.93	FALSE
77	ROSMAP	Brain Pre-frontal Cortex	YPEL3	0.06	0.03	blup	209	0.04	1.9e-05	-4.9	-5.5	4.9e-08	0.06	0.04	0.95	FALSE
78	ROSMAP	Brain Pre-frontal Cortex	STX1B	0.08	0.10	lasso	7	0.10	3.0e-12	-5.4	-5.4	7.3e-08	0.90	0.05	0.95	FALSE
79	ROSMAP	Brain Pre-frontal Cortex	HSD3B7	0.03	0.05	lasso	6	0.02	3.0e-04	-5.3	-5.7	1.0e-08	0.94	0.04	0.96	FALSE
80	ROSMAP	Brain Pre-frontal Cortex	SETD1A	0.02	0.01	blup	232	0.02	4.3e-04	-3.3	-6.0	1.9e-09	0.86	0.06	0.84	FALSE
81	ROSMAP	Brain Pre-frontal Cortex	STX4	0.06	0.11	lasso	10	0.11	1.4e-13	-5.3	5.4	6.2e-08	-0.94	0.05	0.95	FALSE
82	ROSMAP	Brain Pre-frontal Cortex	KAT8	0.13	0.16	lasso	5	0.16	4.2e-20	4.9	-5.6	2.7e-08	0.73	0.39	0.61	FALSE
83	ROSMAP	Brain Pre-frontal Cortex	PRSS36	0.14	0.12	bslmm	241	0.12	1.1e-15	-5.6	-6.1	1.2e-09	0.75	0.02	0.98	FALSE
84	ROSMAP	Brain Pre-frontal Cortex	RP11-196G11.2	0.12	0.12	lasso	4	0.12	1.1e-14	-5.6	-5.5	2.9e-08	1.00	0.03	0.97	FALSE
85	YFS	Blood	PRSS36	0.02	0.02	enet	8	0.02	1.1e-07	-5.6	-5.1	3.0e-07	0.77	0.02	0.98	FALSE
86	YFS	Blood	STX4	0.03	0.06	lasso	2	0.05	4.3e-17	-5.6	-5.6	2.4e-08	0.98	0.03	0.97	FALSE
87	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MYST1	0.04	0.03	enet	4	0.03	1.2e-03	-5.6	-6.1	8.6e-10	0.82	0.05	0.67	FALSE
88	The Cancer Genome Atlas	Breast Invasive Carcinoma	HSD3B7	0.03	0.03	blup	31	0.04	5.2e-08	-5.4	-5.7	1.4e-08	0.92	0.02	0.98	FALSE
89	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYST1	0.05	0.04	blup	34	0.08	2.1e-15	-5.6	-6.4	1.7e-10	0.89	0.06	0.94	FALSE
90	The Cancer Genome Atlas	Breast Invasive Carcinoma	PRSS53	0.03	0.03	blup	38	0.02	6.8e-06	-5.2	5.4	5.3e-08	-0.96	0.02	0.98	FALSE
91	The Cancer Genome Atlas	Esophageal Carcinoma	PPP4C	0.08	0.04	blup	23	0.05	8.9e-03	-5.1	5.2	1.6e-07	-0.07	0.01	0.75	FALSE
92	The Cancer Genome Atlas	Glioblastoma Multiforme	MYST1	0.18	0.07	blup	35	0.11	4.2e-04	4.2	-5.6	1.8e-08	0.78	0.11	0.38	FALSE
93	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HSD3B7	0.06	0.01	blup	31	0.02	7.4e-04	-5.5	-5.5	3.8e-08	0.82	0.02	0.90	FALSE
94	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MYST1	0.08	0.04	blup	34	0.07	7.2e-08	5.0	-6.5	7.8e-11	0.91	0.11	0.89	FALSE
95	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MYST1	0.12	0.09	blup	34	0.10	2.8e-11	-5.6	-5.9	2.9e-09	0.81	0.05	0.95	FALSE
96	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF668	0.02	0.02	blup	32	0.02	2.9e-03	4.2	5.4	7.9e-08	-0.79	0.10	0.54	FALSE
97	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYST1	0.16	0.08	blup	34	0.12	1.5e-13	5.0	-5.8	7.0e-09	0.71	0.28	0.72	FALSE
98	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF668	0.02	0.01	enet	8	0.02	3.1e-03	4.2	5.5	3.4e-08	-0.83	0.03	0.64	FALSE
99	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	HSD3B7	0.08	0.05	blup	31	0.05	1.8e-03	-4.9	-5.3	1.4e-07	0.90	0.02	0.94	FALSE
100	The Cancer Genome Atlas	Lung Adenocarcinoma	DOC2A	0.01	0.02	lasso	2	0.02	2.5e-03	5.1	5.2	2.4e-07	-0.12	0.02	0.77	FALSE
101	The Cancer Genome Atlas	Lung Adenocarcinoma	MYST1	0.09	0.03	blup	33	0.03	1.4e-04	-5.6	-6.0	2.0e-09	0.71	0.05	0.85	FALSE
102	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MYST1	0.08	0.08	enet	8	0.08	2.8e-09	-5.6	-5.9	4.5e-09	0.85	0.06	0.94	FALSE
103	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HSD3B7	0.04	0.04	blup	31	0.05	3.6e-04	-5.3	-5.8	8.8e-09	0.92	0.02	0.87	FALSE
104	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MYST1	0.03	0.05	blup	34	0.03	2.1e-03	4.2	-5.5	4.2e-08	0.77	0.14	0.31	FALSE
105	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	STX1B	0.02	0.01	blup	32	0.01	5.5e-02	-5.3	-5.7	1.3e-08	0.93	0.02	0.60	FALSE
106	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MYST1	0.22	0.15	blup	36	0.21	2.1e-09	5.0	-6.1	9.4e-10	0.83	0.31	0.68	FALSE
107	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HSD3B7	0.09	0.12	blup	31	0.11	4.1e-05	-5.3	-5.7	1.4e-08	0.92	0.02	0.95	FALSE
108	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	MYST1	0.07	0.09	lasso	3	0.07	1.0e-03	-5.5	-5.8	5.5e-09	0.81	0.04	0.54	FALSE
109	The Cancer Genome Atlas	Prostate Adenocarcinoma	MYST1	0.19	0.12	blup	33	0.18	1.5e-18	4.9	-5.5	4.1e-08	0.75	0.40	0.60	FALSE
110	The Cancer Genome Atlas	Prostate Adenocarcinoma	PRSS36	0.17	0.13	blup	27	0.14	1.0e-14	-5.5	-5.9	3.8e-09	0.76	0.01	0.99	FALSE
111	The Cancer Genome Atlas	Rectum Adenocarcinoma	MYST1	0.13	0.05	blup	35	0.06	1.9e-02	5.0	-5.7	1.4e-08	0.76	0.03	0.21	FALSE
112	The Cancer Genome Atlas	Stomach Adenocarcinoma	MYST1	0.04	0.02	blup	35	0.02	8.7e-03	-5.6	-6.3	2.5e-10	0.86	0.02	0.38	FALSE
113	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MYST1	0.13	0.06	blup	34	0.12	6.8e-05	4.9	-5.5	3.0e-08	0.71	0.15	0.55	FALSE
114	The Cancer Genome Atlas	Thyroid Carcinoma	HSD3B7	0.20	0.27	lasso	12	0.28	1.8e-27	-5.5	-5.5	4.9e-08	0.90	0.02	0.98	FALSE
115	The Cancer Genome Atlas	Thyroid Carcinoma	MYST1	0.12	0.10	lasso	3	0.14	1.1e-13	5.0	-6.1	1.1e-09	0.79	0.32	0.68	FALSE