TWAS hub - REEP4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.358	0.1230	3.6e-03	-0.009	NA	0.035	NA	0.014	9.9e-01	NA	2.6e-02	NA	1.1e-01
2	GTEx	Nerve Tibial	0.206	0.0611	7.4e-04	0.066	NA	0.072	NA	0.077	1.9e-05	NA	8.1e-06	NA	3.9e-06
3	YFS	Blood	0.118	0.0208	5.6e-17	0.091	0.068	0.088	0.09	0.089	3.6e-28	3.1e-21	2.8e-27	8.2e-28	1.3e-27

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Mouth/teeth dental problems: Bleeding gums	4.4	5.7	6.2	-2.5	2.2	2.4
Friendships satisfaction	3.7	4.6	7.0	-0.0	2.6	2.6
Chronic bronchitis/emphysema (father)	3.5	4.1	6.9	-1.0	2.6	2.1
Prostate Cancer	3.0	4.3	6.7	0.3	2.6	2.5
Guilty feelings	3.0	4.5	7.5	-0.5	-2.7	-2.4
Medication: Amlodipine	2.9	4.1	6.5	0.1	2.5	2.4
Hair/balding pattern: Pattern 3	2.7	4.0	4.5	-1.7	2.1	2.1
Long-standing illness, disability or infirmity	2.7	4.1	11.8	-3.4	0.4	0.6
Pain all over the body in last month	2.6	2.7	3.4	-1.5	-1.8	-1.7
Frequency of tiredness / lethargy in last 2 weeks	2.5	4.1	11.7	-3.4	0.5	0.7
Family relationship satisfaction	2.5	3.0	5.2	0.8	1.8	2.3
Medication: Lisinopril	2.5	3.3	5.3	-1.1	-2.3	-1.8
Medication: Atorvastatin	2.5	3.0	4.6	0.5	-2.1	-2.1
Supplements: Vitamin C	2.4	2.9	5.1	0.8	2.3	1.7
Reaction Time	2.3	4.3	7.2	-0.5	2.7	2.4
Bilateral oophorectomy (both ovaries removed)	2.3	2.7	4.0	-0.7	1.9	2.0
Fasting Glucose	2.2	2.7	5.0	0.0	2.2	1.7
Medication: Ibuprofen	2.2	2.7	3.6	-0.9	1.9	1.9
Smoking status: Current	2.2	3.5	4.0	2.0	-1.8	-1.8
Taking other prescription medications	2.0	3.0	4.3	-2.1	1.6	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	3.2	0.8	-1.7	-1.8
Ever depressed for a whole week	1.9	2.3	4.0	-0.3	1.7	2.0
Smoking Status	1.8	4.4	11.1	3.3	-1.0	-1.0
Current tobacco smoking	1.8	3.0	3.3	1.8	-1.8	-1.6
Qualifications: CSEs or equivalent	1.8	2.3	3.8	0.2	1.9	1.8
Wears glasses or contact lenses	1.8	2.1	5.7	-2.4	-0.7	-0.4
Major Depression (MDD)	1.7	2.1	3.5	-0.7	1.5	1.9
Blood Platelet Count	1.7	19.4	29.8	-0.3	5.5	5.3
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.9	3.2	-1.8	-1.1	-1.1
Illnesses of father: None of the above (group 1)	1.7	2.1	3.5	-0.0	-1.7	-1.9
Hearing aid user	1.7	1.9	2.7	0.9	-1.5	-1.7
Relative age of first facial hair	1.6	3.3	6.8	-0.5	1.7	2.6
Diverticular disease/diverticulitis (self-reported)	1.6	2.0	3.1	-1.8	1.1	1.2
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.6	5.2	-2.3	-1.4	-0.8
Pulse wave Arterial Stiffness index	1.6	1.9	4.7	-2.2	0.8	0.6
Ever had bowel cancer screening	1.6	1.9	2.8	-1.4	1.7	0.9
Heart disease (siblings)	1.6	1.9	4.2	2.1	0.7	1.0
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	4.9	-2.2	-0.3	0.1
Mineral and other dietary supplements	1.5	2.1	3.6	0.6	-1.9	-1.5
Breast cancer (self-reported)	1.5	1.8	2.9	-0.6	1.7	1.4
Respiratory disease	1.4	3.0	4.7	0.4	-2.2	-2.1
Diabetes (mother)	1.4	1.8	2.9	-0.1	1.7	1.6
Nervous feelings	1.4	2.5	3.0	-1.7	-1.3	-1.7
Medication: Simvastatin	1.4	2.1	4.0	-2.0	-1.4	-0.4
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	2.6	-0.5	1.6	1.6
Mother’s age at death	1.4	1.7	4.9	2.2	-0.0	-0.5
Supplements: Fish oil (including cod liver oil)	1.4	1.8	2.9	-0.7	1.7	1.3
Myopia	1.4	2.0	4.2	-2.1	0.6	1.2
Alzheimer’s Disease (in father)	1.3	1.4	2.5	-1.6	-1.2	-0.6
Supplements: Zinc	1.3	1.4	2.3	1.1	1.5	0.9
Prospective memory result	1.3	1.6	3.1	0.5	-1.2	-1.8
Comparative body size at age 10	1.3	3.6	3.8	1.8	-1.9	-2.0
Pulse wave peak to peak time	1.3	1.5	3.7	1.9	-0.8	-0.5
Rheumatoid Arthritis	1.2	1.6	4.2	-2.0	0.0	0.8
Age when periods started (menarche)	1.2	2.9	5.1	0.2	-2.3	-1.9
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	1.5	1.2	1.2	1.2
Allergy	1.2	2.8	4.6	0.2	2.1	1.9
Number of live births	1.2	1.7	3.9	-0.1	-2.0	-1.1
Headache pain in last month	1.2	2.1	3.3	-0.6	1.7	1.8
Emphysema/chronic bronchitis	1.2	1.4	2.0	0.6	1.4	1.3
Neck or shoulder pain in last month	1.2	1.7	2.0	-1.3	1.2	1.4
Suffer from ‘nerves’	1.2	1.9	5.4	-2.3	0.1	0.4
Age started oral contraceptive pill	1.2	1.6	2.9	-0.3	-1.3	-1.7
Worry (Nagel 2018)	1.1	2.2	6.4	-2.5	0.3	0.4
Age at First Birth	1.1	1.7	2.0	-1.1	1.4	1.3
Sensitivity / hurt feelings	1.1	1.9	5.6	-2.4	0.1	0.0
Time employed in main current job	1.1	1.2	2.0	-0.3	-1.3	-1.4
Health satisfaction	1.1	1.4	1.8	-0.9	-1.4	-1.2
Medication: Seretide 50 evohaler	1.1	1.2	1.9	0.3	-1.3	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	3.1	1.6	1.8	1.1
Medication: Blood pressure	1.1	2.1	3.2	-0.6	1.6	1.8
Alcohol drinker status: Never	1.1	1.3	3.6	-1.9	0.4	0.4
Hearing difficulty/problems: Yes	1.0	1.5	2.7	-0.6	-1.6	-1.1
Maternal smoking around birth	1.0	1.5	2.1	-1.3	0.8	1.4
Falls in the last year	1.0	1.3	3.2	1.8	0.8	0.2
Lung cancer (father)	1.0	1.1	1.6	1.0	1.3	0.9
Birth weight	1.0	2.3	4.0	-0.3	-2.0	-1.6
Number of operations (self-reported)	1.0	1.5	2.6	-0.3	1.6	1.4
Schizophrenia (2018)	0.9	2.0	3.0	-1.7	0.0	-1.7
Breast Cancer	0.9	2.1	4.2	-1.0	1.1	2.0
HbA1C	0.9	1.0	3.0	-1.7	-0.0	0.2
Schizophrenia (2014)	0.9	2.1	3.1	-1.8	0.0	-1.8
Number of treatments/medications taken	0.9	1.5	2.2	-0.8	1.4	1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	5.8	2.4	-0.4	-0.4
Hearing difficulty/problems with background noise	0.9	1.5	2.5	-0.2	-1.6	-1.3
Worrier / anxious feelings	0.9	1.6	3.6	-1.9	-0.7	-0.9
Tense / ‘highly strung’	0.9	1.5	4.2	-2.0	0.0	0.5
Shortness of breath walking on level ground	0.9	1.1	2.7	1.6	-0.7	-0.4
Mean time to correctly identify matches	0.9	1.6	2.5	-1.0	1.6	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	1.2	1.0	-1.0	-1.1
Commuting to job workplace: Walk	0.9	0.9	1.4	1.2	-1.0	-0.6
Illnesses of father: High blood pressure	0.9	1.1	2.0	0.3	1.1	1.4
Risk taking	0.9	1.3	1.9	1.4	0.9	1.0
Pain experienced in last month	0.9	1.5	2.6	0.1	-1.3	-1.6
Bipolar Disorder or Schizophrenia	0.8	2.0	3.4	-1.6	0.0	-1.8
Ovarian Cancer	0.8	1.0	1.3	0.8	1.1	1.1
Number of incorrect matches in round	0.8	1.4	2.7	-0.1	1.7	1.2
Mouth/teeth dental problems	0.8	1.3	2.2	1.5	-1.0	-0.9
Neuroticism score	0.8	1.6	2.9	-1.7	-1.0	-0.9
Asthma	0.8	1.6	2.8	-0.5	-1.7	-1.2
Medication: Cholesterol lowering	0.8	1.2	2.5	0.3	-1.6	-1.1
Illnesses of mother	0.8	0.9	1.7	0.0	-1.3	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	2.3	-0.5	1.1	1.5
Leg pain on walking	0.8	1.0	2.8	1.7	0.3	0.4
Back pain experienced in last month	0.8	1.1	2.0	-0.3	1.1	1.4
Number of self-reported non-cancer illnesses	0.8	1.4	2.7	-1.6	0.8	0.9
Lupus	0.7	1.1	1.5	-1.1	1.2	0.7
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.1	-1.4	0.0	0.5
Vitamin and mineral supplements	0.7	1.0	1.3	1.0	-1.1	-0.9
Diabetes (father)	0.7	0.9	1.4	-1.2	-0.8	-0.8
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.1	-0.4	0.9	1.1
Multivitamins +/- minerals	0.7	0.8	1.4	-0.1	1.1	1.2
Had menopause	0.7	0.9	1.1	-1.1	-0.9	-0.8
Qualifications: None of the above	0.7	1.5	2.5	1.6	-1.1	-0.9
Financial difficulties in last 2 years	0.7	0.9	1.7	-0.3	0.9	1.3
Depression (self-reported)	0.7	0.8	1.8	-1.3	0.6	0.6
Exposure to tobacco smoke at home	0.7	0.8	1.6	0.5	-1.3	-0.8
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	1.8	0.7	1.3	1.0
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	3.7	1.9	-0.0	-0.7
Qualifications: College or University degree	0.7	2.3	4.8	-2.2	-0.8	-1.1
Chest pain or discomfort	0.7	1.0	2.9	-1.7	0.1	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.5	1.2	0.6	0.7
Osteoarthritis (self-reported)	0.7	0.9	1.6	-1.3	0.9	0.6
Average weekly beer plus cider intake	0.7	1.1	1.4	1.0	0.9	1.2
Neuroticism (Nagel 2018)	0.6	1.4	3.7	-1.9	-0.5	-0.3
Alzheimer’s Disease (including proxy)	0.6	0.8	2.4	-1.5	-0.2	-0.1
Crohns Disease (2012)	0.6	1.0	2.0	-0.1	-1.4	-1.0
HDL Cholesterol	0.6	1.0	1.5	-0.8	0.9	1.2
Waist Hip Ratio (WHR)	0.6	2.8	4.5	-0.4	2.0	2.1
Cardiovascular Disease	0.6	2.0	3.1	-1.8	0.9	1.4
Lung FVC	0.6	3.1	4.6	1.5	-1.6	-2.1
Stomach or abdominal pain in last month	0.6	0.8	1.3	-0.9	0.6	1.1
Medication: Levothyroxine sodium	0.6	1.0	2.0	1.4	-0.6	-0.7
High blood pressure (mother)	0.6	0.8	1.5	-0.4	1.2	0.8
Peak expiratory flow (PEF)	0.6	1.3	2.0	0.5	1.4	1.4
Loud music exposure frequency	0.6	0.7	0.7	-0.8	0.8	0.9
Medication: Paracetamol	0.6	1.1	1.9	0.2	1.1	1.4
Wheeze or whistling in the chest in last year	0.6	1.0	2.8	-1.7	-0.3	0.3
Medication: Blood pressure	0.6	1.1	1.8	-0.8	-1.0	-1.4
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.1	0.8	1.1	0.6
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.5	-0.7	1.0	1.2
Asthma (self-reported)	0.6	1.3	2.3	-0.5	-1.5	-1.1
Financial situation satisfaction	0.6	0.8	2.3	1.5	0.1	0.2
Cholesterol lowering medication	0.6	0.8	1.4	-1.2	0.3	1.0
Depression (Nagel 2018)	0.5	0.7	0.9	-0.6	-1.0	-0.9
LDL Cholesterol	0.5	0.9	1.2	-0.3	-1.1	-1.1
Blood White Count	0.5	3.5	6.0	0.5	2.4	2.0
Systolic Blood Pressure	0.5	2.4	4.5	-0.5	2.1	1.5
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.1	-0.3	-0.9	-1.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.8	0.3	-0.8	-0.9
Severe depression (siblings)	0.5	0.6	0.8	-0.9	0.7	0.7
Townsend deprivation index at recruitment	0.5	0.7	1.4	0.1	0.9	1.2
Hayfever, allergic rhinitis or eczema	0.5	1.2	1.6	-0.6	-1.2	-1.2
Sitting height	0.5	3.3	6.4	0.1	-2.5	-1.9
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.8	-1.3	0.0	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.4	-0.3	0.6	1.2
Pulse rate, automated reading	0.5	1.5	2.9	-0.3	-1.2	-1.7
Age at last live birth	0.5	0.7	0.8	-0.9	0.9	0.8
Illnesses of father: Heart disease	0.5	0.7	1.8	1.3	0.1	0.5
Qualifications: nursing, teaching	0.5	0.8	0.9	-0.9	-0.8	-1.0
Medication for cholesterol	0.5	0.8	1.8	0.1	-0.7	-1.4
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.3	-0.2	-0.7	-1.1
Ulcerative Colitis (UC)	0.4	0.7	1.4	-1.2	0.6	0.6
Allergy or Eczema	0.4	1.2	2.0	0.5	-1.1	-1.4
Hypothyroidism (self reported)	0.4	1.0	2.5	1.6	0.7	0.1
Neuroticism	0.4	1.0	3.1	-1.8	0.1	-0.0
Average weekly spirits intake	0.4	0.6	1.7	1.3	0.1	0.0
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.1	-1.1	-0.6	-0.3
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.1	1.1	0.2	0.6
Pack years adult smoking proportion	0.4	0.6	1.0	-1.0	0.3	0.8
Waist circumference	0.4	1.5	2.7	0.7	1.1	1.6
Past tobacco smoking	0.4	0.8	1.0	-1.0	-0.8	-0.8
Alcohol usually taken with meals	0.4	0.7	1.5	-1.2	0.5	0.6
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.7	0.6	-0.5	-0.8
Illnesses of siblings	0.4	0.6	0.9	-0.5	-0.9	-0.9
Noisy workplace	0.4	0.6	1.6	1.3	-0.1	0.2
Impedance of arm (left)	0.4	1.8	3.2	-1.8	-0.5	-1.4
Birth weight of first child	0.4	0.7	1.5	-1.2	-0.6	-0.5
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.9	0.2	0.7	1.0
Worry too long after embarrassment	0.4	0.6	0.9	0.3	-0.9	-1.0
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.7	-0.9	-0.7	-0.3
Average weekly red wine intake	0.4	0.6	1.9	1.4	0.1	-0.0
Diabetes diagnosed by doctor	0.4	0.6	1.1	-0.5	0.7	1.1
Osteoporosis (self-reported)	0.4	0.5	1.3	-1.1	-0.2	-0.3
Medication: Aspirin	0.4	0.6	0.9	0.5	-0.9	-0.7
Medication: Gliclazide	0.4	0.5	0.7	0.8	-0.8	-0.4
Eye problems/disorders: Glaucoma	0.4	0.5	1.2	1.1	0.3	-0.5
High cholesterol (Self-reported)	0.4	0.7	1.0	-1.0	-1.0	0.0
Medication: Bendroflumethiazide	0.4	0.6	1.0	1.0	0.7	0.6
Irritability	0.4	0.7	1.2	-0.7	-1.1	-0.6
Fractured/broken bones in last 5 years	0.4	0.5	1.2	1.1	0.6	0.0
Commuting to job workplace: Cycle	0.4	0.4	1.3	-1.1	0.2	0.0
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.7	1.3	-0.8	-0.2
Coronary Artery Disease (CAD)	0.3	0.3	0.9	-1.0	0.0	0.2
Mean Putamen Volume	0.3	0.3	0.4	-0.5	-0.5	-0.7
Neuroticism (2016)	0.3	0.4	0.6	-0.5	-0.8	-0.6
Ulcerative Colitis	0.3	0.4	1.0	0.5	0.0	-1.0
Blood Red Count	0.3	3.1	8.6	2.9	0.9	0.3
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.9	-0.5	0.6	0.9
Hand grip strength (left)	0.3	0.8	2.1	1.5	0.4	0.5
Medication: Co-codamol	0.3	0.3	0.8	-0.9	-0.2	-0.2
Impedance of leg (right)	0.3	1.2	3.1	-1.8	0.7	0.2
Fed-up feelings	0.3	0.5	1.2	-1.1	0.1	0.6
Body mass index (BMI)	0.3	1.4	3.3	1.8	0.4	1.0
Impedance of leg (left)	0.3	1.3	3.6	-1.9	0.6	-0.0
Hair/balding pattern: Pattern 2	0.3	0.4	1.2	1.1	0.3	-0.1
Impedance of arm (right)	0.3	1.3	2.6	-1.6	-0.3	-1.0
Alcohol intake versus 10 years previously	0.3	0.4	0.9	-1.0	0.3	0.2
Father’s age at death	0.3	0.4	1.2	-1.1	0.0	-0.3
Arm fat mass (right)	0.3	1.1	1.9	1.4	0.5	1.0
Pulse wave reflection index	0.3	0.3	0.8	-0.9	0.2	0.4
Glaucoma (self-reported)	0.3	0.3	0.7	0.8	-0.1	-0.5
High blood pressure (siblings)	0.3	0.5	1.0	0.3	1.0	0.6
Leg fat percentage (right)	0.3	1.2	1.8	0.7	1.2	1.3
Number of full brothers	0.3	0.4	1.0	1.0	-0.2	0.3
Number of children fathered	0.3	0.4	0.9	-0.9	-0.4	0.2
Medication for pain relief, constipation, heartburn	0.3	0.5	1.0	-1.0	-0.3	-0.6
Medication: Omeprazole	0.3	0.4	0.4	-0.6	-0.6	-0.7
Leg fat mass (right)	0.3	1.3	1.8	1.3	0.7	1.3
Had major operations	0.3	0.3	1.0	1.0	-0.1	-0.3
Smoking status: Previous	0.3	0.5	0.6	0.4	0.8	0.8
Mood swings	0.3	0.6	1.2	-1.1	0.4	0.7
Medication: Paracetamol	0.3	0.5	0.9	-0.4	0.7	1.0
Leg fat percentage (left)	0.3	1.0	1.5	0.6	1.0	1.2
Diastolic blood pressure, automated reading	0.3	1.0	1.4	0.8	1.2	1.0
Supplements: Calcium	0.3	0.4	0.6	0.6	-0.8	-0.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.5	-0.7	0.5	0.6
Impedance of whole body	0.3	1.6	4.2	-2.0	0.0	-0.8
Leg fat mass (left)	0.3	1.2	1.8	1.3	0.6	1.2
Bipolar Disorder (2018)	0.2	0.3	0.6	-0.4	0.0	-0.8
Angina	0.2	0.3	0.5	0.0	-0.6	-0.7
Leg fat-free mass (left)	0.2	1.2	3.1	1.8	-0.3	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.8	-0.9	-0.3	0.0
Serious illness, injury or assault to yourself	0.2	0.2	0.5	-0.2	0.7	0.2
High blood pressure	0.2	0.6	1.2	-1.1	0.5	0.5
Supplements: Glucosamine	0.2	0.2	0.3	0.5	0.5	0.2
Medication: Atenolol	0.2	0.2	0.5	-0.3	-0.7	-0.2
Leg predicted mass (left)	0.2	1.1	3.1	1.8	-0.4	0.5
Had other major operations	0.2	0.3	0.5	-0.7	0.4	0.4
Heart attack	0.2	0.3	0.5	-0.7	0.3	0.5
Medication: Ramipril	0.2	0.3	0.4	0.6	-0.2	-0.7
Weight	0.2	0.9	1.8	1.4	0.3	0.9
Happiness	0.2	0.2	0.6	-0.7	-0.0	0.3
Mouth/teeth dental problems: Dentures	0.2	0.3	0.4	0.5	-0.5	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	2.3	1.5	0.0	0.1
Length of working week for main job	0.2	0.2	0.6	0.7	-0.2	-0.1
Gout (self-reported)	0.2	0.3	0.7	0.9	-0.3	-0.1
Forced vital capacity (FVC), Best measure	0.2	0.6	0.8	0.9	-0.8	-0.6
Arm fat-free mass (right)	0.2	0.9	1.9	1.4	0.0	1.0
Exposure to tobacco smoke outside home	0.2	0.3	0.7	0.4	0.2	0.8
Eye problems/disorders: None of the above	0.2	0.2	0.5	-0.3	-0.7	-0.4
Medication: Allopurinol	0.2	0.3	0.4	0.6	0.4	0.6
Heart disease (mother)	0.2	0.3	0.5	-0.5	-0.7	-0.4
Whole body fat mass	0.2	0.7	1.5	1.2	0.2	0.7
Arm predicted mass (right)	0.2	1.1	2.5	1.6	0.1	0.9
Alcohol intake frequency.	0.2	0.4	1.0	-1.0	0.5	0.1
Overall health rating	0.2	0.5	1.1	-1.1	0.1	0.5
Illnesses of siblings: Diabetes	0.2	0.2	0.3	-0.4	0.5	0.4
Leg fat-free mass (right)	0.2	0.9	2.5	1.6	-0.4	0.4
Eye problems/disorders: Cataract	0.2	0.2	0.3	0.6	0.5	0.0
Whole body water mass	0.2	0.9	2.1	1.4	-0.2	0.7
Leg predicted mass (right)	0.2	0.9	2.4	1.5	-0.5	0.3
Arm fat mass (left)	0.2	1.0	1.7	1.3	0.5	1.1
Average weekly champagne plus white wine intake	0.2	0.3	0.6	-0.1	0.5	0.7
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.7	0.9	0.2	0.3
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.4	0.5	0.7	0.1
Basal metabolic rate	0.2	1.0	2.2	1.5	-0.0	0.9
Arm fat-free mass (left)	0.2	0.9	1.8	1.3	0.1	1.0
Unable to work because of sickness or disability	0.2	0.3	0.5	-0.1	-0.6	-0.7
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.8	0.9	-0.6	-0.7
Pack years of smoking	0.2	0.4	0.8	-0.9	0.0	0.6
Arm predicted mass (left)	0.2	1.1	2.3	1.5	0.1	1.0
Schizophrenia vs Biploar Disorder	0.1	0.2	0.4	-0.4	0.0	0.6
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.5	0.2	-0.1
Crohns Disease (2017)	0.1	0.2	0.3	-0.4	0.5	0.5
Irritable Bowel Disease (IBD)	0.1	0.3	0.6	-0.8	0.3	0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.5	0.1	0.5	0.7
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	0.0	0.0	-0.5
Primary Biliary Cirrhosis	0.1	0.1	0.2	0.4	0.1	-0.4
Triglycerides	0.1	0.1	0.3	-0.4	-0.1	-0.5
Blood Eosinophil Count	0.1	0.6	0.9	-0.6	0.8	1.0
Heel T-Score	0.1	0.9	1.9	1.4	0.7	0.5
BMI	0.1	0.8	2.0	1.4	-0.4	0.4
Height	0.1	2.1	3.2	-0.1	-1.8	-1.8
Lung FEV1/FVC ratio	0.1	0.6	1.2	0.0	1.1	0.7
Chronotype (morning person)	0.1	0.2	0.4	-0.7	0.1	0.5
Hair Pigment	0.1	3.0	3.9	1.3	1.9	2.0
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	-0.1	0.1	0.4
Medication for hormone replacement therapy	0.1	0.1	0.2	0.0	-0.4	-0.4
Medication: Metformin	0.1	0.1	0.3	-0.6	-0.1	0.3
Trunk fat percentage	0.1	0.2	0.5	0.7	0.3	0.4
Hand grip strength (right)	0.1	0.4	1.0	1.0	0.1	0.4
Average weekly fortified wine intake	0.1	0.1	0.2	0.2	0.3	0.4
Relative age voice broke	0.1	0.2	0.3	-0.5	-0.5	-0.1
Trunk fat mass	0.1	0.5	1.1	1.0	0.3	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.8	0.9	-0.3	0.0
Fluid intelligence score	0.1	0.2	0.6	-0.8	-0.0	0.4
Arm fat percentage (right)	0.1	0.4	1.0	1.0	0.3	0.5
Trunk fat-free mass	0.1	0.6	1.2	1.1	-0.2	0.8
Hip circumference	0.1	0.5	1.1	1.1	0.0	0.6
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	0.6	0.8	0.5	0.8
Pulse rate	0.1	0.1	0.1	-0.3	0.2	-0.4
Medication: Lansoprazole	0.1	0.1	0.1	-0.3	0.3	-0.3
Trunk predicted mass	0.1	0.6	1.2	1.1	-0.1	0.8
Breastfed as a baby	0.1	0.2	0.4	0.6	0.1	-0.3
Hair/balding pattern: Pattern 4	0.1	0.3	1.0	1.0	0.1	-0.1
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	0.1	0.1	0.5
Blood clot in the leg (DVT)	0.1	0.1	0.3	-0.0	-0.5	-0.4
Body fat percentage	0.1	0.2	0.5	0.7	0.2	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	0.5	0.2	-0.2
Age at first live birth	0.1	0.1	0.3	0.1	0.6	0.3
Angina (self-reported)	0.1	0.1	0.2	-0.1	-0.4	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	0.2	-0.2	-0.4
Comparative height size at age 10	0.1	0.6	1.5	-1.2	0.4	0.2
Number of full sisters	0.1	0.2	0.5	0.7	0.1	0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.2	0.5	-0.1	-0.5
Medication: Aspirin	0.1	0.1	0.4	0.0	-0.6	-0.1
Knee pain experienced in last month	0.1	0.2	0.4	0.2	0.6	0.5
Hypertension (Self-reported)	0.1	0.4	0.9	-1.0	0.4	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.8	0.9	-0.4	0.0
Whole body fat-free mass	0.1	0.7	1.6	1.3	-0.3	0.6
Arm fat percentage (left)	0.1	0.4	0.8	0.9	0.3	0.6
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.4	0.1	0.3
Ever smoked	0.1	0.2	0.6	0.8	0.2	0.1
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	-0.4	-0.3	-0.1
Alcohol drinker status: Previous	0.1	0.1	0.2	0.3	0.1	-0.4
Depressed Affect (Nagel 2018)	0.0	0.0	0.0	0.1	0.1	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Tanning	0.0	0.6	0.8	-0.7	0.9	0.7
Systolic blood pressure, automated reading	0.0	0.1	0.2	0.3	0.4	0.3
Forced vital capacity (FVC)	0.0	0.1	0.2	0.5	-0.2	0.3
Diabetes (self-reported)	0.0	0.0	0.0	-0.0	-0.0	0.0
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.0	0.0	-0.2	0.1
Standing height	0.0	0.3	0.3	-0.5	-0.6	-0.3
Qualifications: O levels/GCSEs or equivalent	0.0	0.1	0.2	-0.1	0.2	0.4
Migraine (self-reported)	0.0	0.0	0.1	-0.2	0.3	0.1
Handedness (chirality/laterality): Left-handed	0.0	0.1	0.1	-0.4	0.1	0.2
Loneliness, isolation	0.0	0.0	0.1	-0.1	-0.3	0.2
Miserableness	0.0	0.0	0.0	0.2	-0.0	0.2
Commuting to job workplace: Public transport	0.0	0.0	0.1	0.0	-0.1	0.3
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	-0.2	-0.0	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.0	0.0	-0.2	-0.2

Hub : Genes

REEP4

Models

Trait associations