Hub : Genes

SORBS3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.051 0.0200 0.0018 0.012 0.02 0.008 0.019 0.011 0.0110 0.0015 0.0290 0.0017 0.01500
2 GTEx Brain Cerebellar Hemisphere 0.232 0.0920 0.0064 0.106 NA 0.065 NA 0.124 0.0011 NA 0.0096 NA 0.00044
3 GTEx Brain Cerebellum 0.316 0.1240 0.0038 0.007 NA 0.000 NA 0.040 0.1900 NA 0.3300 NA 0.02500
4 GTEx Nerve Tibial 0.119 0.0474 0.0050 0.013 NA -0.002 NA 0.008 0.0400 NA 0.4900 NA 0.08700

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 3.1 4.8 9.4 -0.9 2.4 1.8 -3.1
Bipolar Disorder or Schizophrenia 2.2 5.3 10.4 -1.6 1.4 2.5 -3.2
Depressed Affect (Nagel 2018) 2.3 4.9 12.1 0.3 -3.5 -1.2 2.5
Depression (Nagel 2018) 1.1 1.7 3.4 0.6 -1.9 -0.2 1.7
Intelligence (Savage-Jansen 2018) 0.4 1.2 1.9 1.2 -1.4 -1.2 -0.2
Neuroticism (Nagel 2018) 1.2 2.8 6.4 -1.9 -2.5 0.1 1.1
Schizophrenia (2018) 0.7 1.5 2.5 -1.3 -0.1 1.3 -1.6
Schizophrenia vs Biploar Disorder 2.6 3.4 13.0 0.6 -0.6 0.3 3.6
Worry (Nagel 2018) 1.1 2.4 8.6 -2.9 -0.4 0.7 -0.4
Alzheimer’s Disease (in mother) 1.3 1.6 2.7 -0.4 1.0 1.6 -1.5
Alzheimer’s Disease (in father) 0.6 0.7 2.3 0.3 1.5 0.4 0.3
Alzheimer’s Disease (including proxy) 1.3 1.9 4.5 0.2 1.5 2.1 -0.9
Crohns Disease (2017) 0.3 0.7 1.5 -1.2 0.1 1.1 -0.2
Irritable Bowel Disease (IBD) 0.1 0.2 0.7 -0.2 -0.3 0.2 -0.8
Ulcerative Colitis (UC) 0.1 0.2 0.5 0.7 0.1 -0.2 -0.6
Major Depression (MDD) 2.0 2.5 6.7 -1.4 -1.1 0.0 -2.6
Reaction Time 0.9 1.7 3.0 1.7 -1.3 -1.4 0.2
Verbal and Numeric Reasoning (VNR) 1.1 2.7 5.2 0.5 -2.3 -0.8 -2.2
Breast Cancer 1.0 2.3 4.6 -1.5 -2.1 1.4 0.6
Ovarian Cancer 2.1 2.7 5.3 2.3 1.1 -1.8 1.1
Prostate Cancer 0.5 0.7 1.5 -0.9 -0.4 -0.4 1.2
Age at First Birth 1.0 1.5 4.5 -2.1 1.1 -0.0 -0.4
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.6 2.3 0.2 -0.3 -0.3 1.5
Coronary Artery Disease (CAD) 1.4 1.6 2.9 -0.6 1.6 1.7 -0.7
Crohns Disease (2012) 1.0 1.7 3.0 -1.7 0.9 1.5 -0.8
Mean Putamen Volume 0.1 0.1 0.2 -0.4 0.4 0.3 -0.3
Fasting Glucose 1.0 1.2 3.5 -0.3 -0.2 -1.1 -1.9
HbA1C 0.1 0.1 0.2 -0.5 0.3 0.2 -0.3
HDL Cholesterol 0.4 0.7 1.9 1.4 -0.6 -0.7 0.1
LDL Cholesterol 0.8 1.2 2.4 -0.9 1.2 0.5 1.6
Lupus 2.0 3.0 7.6 -1.8 1.0 2.8 0.6
Neuroticism (2016) 0.4 0.6 1.3 -1.1 -0.6 0.0 0.8
Primary Biliary Cirrhosis 0.4 0.6 1.3 -0.1 0.3 -1.1 1.0
Rheumatoid Arthritis 0.5 0.7 2.0 1.4 -0.1 -0.7 0.7
Schizophrenia (2014) 0.3 0.7 1.5 -1.0 0.4 1.2 -0.5
Triglycerides 0.8 1.3 4.6 -0.4 2.1 -0.2 0.6
Type 2 Diabetes (T2D) (2012) 0.8 0.9 1.5 -1.2 -1.2 0.4 -0.7
Ulcerative Colitis 0.7 1.1 2.8 1.7 0.1 -0.6 1.1
Blood Eosinophil Count 0.9 7.3 12.8 3.6 2.2 -2.8 -1.9
Blood Platelet Count 1.5 17.7 59.1 -2.0 7.7 -1.2 -2.6
Blood Red Count 0.4 3.8 10.0 3.2 -1.2 -1.7 0.8
Blood White Count 0.5 3.7 9.1 0.8 3.0 -1.9 -1.2
Heel T-Score 0.2 1.2 3.3 -0.4 -1.1 -1.8 -0.2
BMI 0.4 2.5 4.1 -2.0 -1.8 -1.4 0.8
Height 0.6 11.8 18.8 4.3 -3.5 -3.9 -1.2
Waist Hip Ratio (WHR) 0.5 2.4 6.1 1.6 2.5 -0.8 0.2
Systolic Blood Pressure 1.4 6.8 20.0 -2.2 4.5 0.3 -1.5
Smoking Status 5.0 12.0 23.6 4.9 -1.7 -3.2 3.3
Allergy or Eczema 2.9 7.8 16.9 -3.5 1.0 1.0 -4.1
Cardiovascular Disease 1.5 4.9 15.2 -3.9 1.3 -1.4 -0.9
Hypothyroidism (self reported) 0.6 1.3 5.1 0.2 0.0 -2.3 0.4
Respiratory disease 0.2 0.5 1.1 -0.7 -1.1 0.2 -0.6
Type 2 Diabetes (T2D) (2018) 1.3 2.4 8.9 -0.3 3.0 0.8 -0.0
Lung FEV1/FVC ratio 1.2 6.1 20.3 -1.4 4.5 -0.9 -1.2
Lung FVC 1.5 7.9 20.6 0.4 -4.5 0.9 3.2
Neuroticism 1.4 3.5 12.6 -0.7 -3.6 -0.3 0.8
Chronotype (morning person) 0.2 0.5 1.7 0.5 0.3 -0.1 1.3
Hair Pigment 0.5 13.8 31.1 -5.6 -2.3 0.3 -4.3
Tanning 0.2 2.2 6.6 2.6 0.2 -1.5 0.2
Hand grip strength (left) 1.3 3.5 7.5 2.3 -1.0 -2.7 -0.5
Number of treatments/medications taken 2.5 4.4 9.4 -3.1 1.7 0.6 -2.2
Average weekly spirits intake 0.8 1.0 2.4 -1.6 -0.6 -1.0 0.5
Sensitivity / hurt feelings 1.2 2.0 5.9 -2.4 0.4 1.2 -0.7
Frequency of depressed mood in last 2 weeks 0.8 1.1 3.1 1.1 -1.8 0.0 0.3
Hearing difficulty/problems: Yes 1.0 1.5 5.1 -0.1 -2.3 -0.2 0.8
Relative age of first facial hair 0.7 1.5 2.3 -0.6 1.5 1.5 -1.0
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 2.2 -0.7 -1.5 -0.8 1.2
Ever used hormone-replacement therapy (HRT) 0.6 0.7 2.9 -1.7 0.1 0.1 -0.2
Ever had hysterectomy (womb removed) 0.6 0.6 1.9 -1.4 0.0 -0.7 0.3
Systolic blood pressure, automated reading 1.2 3.5 11.8 -3.4 1.0 0.7 -0.8
Eye problems/disorders: Diabetes related eye disease 1.2 1.4 3.9 0.8 2.0 0.0 1.0
Angina 1.4 1.8 4.2 -0.6 2.1 -1.4 -0.9
Medication for hormone replacement therapy 0.1 0.1 0.2 -0.2 0.2 0.5 -0.3
Vitamin and mineral supplements 1.3 1.7 4.6 1.4 -0.7 0.1 2.1
Supplements: Zinc 0.4 0.5 1.3 -0.3 0.3 1.1 -0.6
Medication: Co-codamol 1.6 1.8 4.3 -0.0 1.4 1.0 2.1
Medication: Metformin 1.5 2.1 3.6 -1.3 1.9 1.8 -0.2
Diabetes (father) 2.0 2.5 4.3 -1.1 2.1 1.5 -1.5
Diabetes (mother) 0.9 1.2 2.8 0.8 1.7 0.6 1.0
Severe depression (siblings) 0.4 0.4 1.1 0.5 -0.5 -1.1 -0.0
Pack years adult smoking proportion 0.3 0.5 0.9 -0.5 1.0 -0.3 -0.7
Impedance of leg (right) 0.7 3.5 12.6 -0.6 3.5 0.4 -0.8
Leg fat-free mass (left) 1.0 5.2 14.2 1.0 -3.8 -2.3 0.2
Trunk fat percentage 1.0 3.9 14.3 -3.8 -0.8 -0.0 0.9
Hand grip strength (right) 1.7 4.7 12.6 3.5 -1.3 -2.2 -0.1
Townsend deprivation index at recruitment 0.8 1.1 2.6 0.7 -1.6 -0.1 1.2
Current tobacco smoking 3.5 5.8 14.7 3.8 0.1 -2.3 1.8
Average weekly fortified wine intake 0.4 0.4 1.0 0.2 -1.0 0.0 -0.8
Maternal smoking around birth 1.9 2.7 5.8 -1.7 -0.2 2.4 1.5
Fed-up feelings 0.9 1.6 5.3 -0.4 -2.3 0.8 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 3.9 1.5 -2.0 0.0 1.3
Relative age voice broke 0.6 1.0 2.1 -1.4 0.9 0.6 -0.9
Taking other prescription medications 2.1 3.2 9.5 -3.1 1.2 0.1 -1.4
Age when periods started (menarche) 0.3 0.7 1.3 0.6 1.1 -0.0 -1.1
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.4 0.2 0.3 0.0 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.9 0.4 -0.1 -1.0 0.4
Tinnitus: Yes, but not now, but have in the past 0.4 0.5 0.9 -0.5 0.8 -0.3 -1.0
Qualifications: CSEs or equivalent 0.2 0.3 0.5 0.2 -0.2 0.7 0.7
Serious illness, injury or assault to yourself 0.6 0.8 2.9 0.1 -1.7 0.4 0.1
High blood pressure 1.1 3.2 10.4 -3.2 1.2 -0.7 -0.6
Hayfever, allergic rhinitis or eczema 4.9 10.7 18.2 -4.3 1.6 2.0 -4.2
Multivitamins +/- minerals 0.9 1.2 3.1 -1.2 0.0 0.6 -1.8
Stomach or abdominal pain in last month 0.6 0.8 1.6 -0.0 -1.3 -1.2 -0.2
Supplements: Glucosamine 0.3 0.4 1.3 -0.0 -0.4 -1.2 -0.5
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.2 -1.1 1.1 0.3 -0.4
Medication: Atenolol 0.4 0.5 1.7 0.2 1.3 -0.5 -0.4
Medication: Levothyroxine sodium 1.2 2.1 7.1 0.6 0.2 -2.7 1.0
Sitting height 0.3 1.8 3.2 1.8 -1.0 -1.7 -0.4
Chronic bronchitis/emphysema (father) 1.4 1.6 3.5 -1.5 -1.9 0.4 -0.7
High blood pressure (mother) 0.9 1.2 3.5 -0.1 0.9 0.8 1.9
Body mass index (BMI) 1.0 4.2 12.2 -3.5 -1.9 -0.2 1.0
Impedance of leg (left) 0.7 3.2 12.0 -0.7 3.5 0.5 -0.4
Leg predicted mass (left) 1.0 5.2 14.4 1.0 -3.8 -2.3 0.2
Trunk fat mass 0.8 3.3 8.1 -2.8 -2.0 -1.0 0.6
Waist circumference 0.5 1.8 3.2 -1.8 -1.7 -0.9 0.6
Number of incorrect matches in round 0.7 1.2 2.8 -0.5 1.7 1.1 0.9
Past tobacco smoking 1.3 2.5 3.7 -1.9 1.6 1.3 -1.3
Alcohol usually taken with meals 0.4 0.7 2.1 1.4 -0.0 0.2 -0.9
Nervous feelings 0.8 1.5 4.0 -2.0 0.2 1.2 -0.7
Frequency of tenseness / restlessness in last 2 weeks 1.4 2.2 4.6 -0.2 -1.8 2.2 -0.9
Hearing difficulty/problems with background noise 1.2 2.0 5.8 -1.4 -2.4 0.1 0.5
Hair/balding pattern: Pattern 2 0.8 1.1 1.7 -1.2 -1.3 1.0 -0.4
Had menopause 0.5 0.7 2.3 -1.5 0.1 0.2 0.6
Had other major operations 1.8 2.2 3.9 -0.5 1.8 1.2 -2.0
Forced vital capacity (FVC) 1.1 4.2 7.2 2.5 -2.7 -1.2 1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.1 0.1 0.3 0.1 -0.3 0.4
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 2.3 0.0 -1.5 0.3 -1.5
Qualifications: None of the above 0.2 0.5 1.5 -0.0 -1.2 -0.4 0.6
Financial difficulties in last 2 years 0.8 1.0 1.8 -1.4 -1.1 0.1 -1.0
Mouth/teeth dental problems 0.7 1.1 1.9 0.7 -0.5 -1.4 1.3
Heart attack 1.8 2.3 6.0 -1.7 -0.6 0.1 -2.5
Allergy 3.6 8.3 17.6 3.6 -1.3 -0.8 4.2
Pain all over the body in last month 0.0 0.0 0.1 -0.3 0.2 -0.1 -0.1
Diabetes (self-reported) 1.0 1.6 6.1 0.3 2.5 0.0 0.3
Hayfever/allergic rhinitis (self-reported) 2.0 2.6 5.1 -2.3 -0.2 0.9 -2.1
Medication: Ramipril 1.3 1.6 4.3 -1.2 2.1 0.6 -0.6
Medication: Simvastatin 2.2 3.2 9.4 -3.1 1.2 1.1 -0.9
Fluid intelligence score 1.4 2.9 6.1 0.4 -2.2 -0.6 -2.5
Illnesses of siblings 0.4 0.5 0.8 0.7 -0.9 -0.1 0.8
Neuroticism score 1.0 2.0 6.7 -0.7 -2.6 0.9 0.3
Weight 0.8 3.8 9.7 -1.1 -3.1 -2.0 0.4
Impedance of arm (right) 0.5 2.5 8.7 0.0 2.9 0.9 -0.7
Arm fat percentage (right) 1.3 4.9 18.2 -4.3 -1.2 0.4 0.2
Trunk fat-free mass 1.6 8.9 21.1 1.8 -4.6 -3.4 -0.3
Hip circumference 0.9 4.0 9.6 -2.3 -3.1 -0.9 0.5
Time employed in main current job 0.3 0.3 1.0 -0.4 -0.2 -1.0 0.3
Alcohol intake versus 10 years previously 0.4 0.6 1.5 -1.2 0.8 0.4 -0.1
Father’s age at death 0.4 0.5 1.1 1.0 0.2 0.8 0.5
Worrier / anxious feelings 0.5 0.9 2.0 -1.4 1.1 0.4 -0.3
Frequency of tiredness / lethargy in last 2 weeks 2.1 3.4 5.4 -2.3 -2.3 1.6 -0.5
Falls in the last year 0.7 1.0 2.3 -0.2 -1.0 -1.5 -0.7
Hair/balding pattern: Pattern 3 1.0 1.5 4.7 2.2 1.1 -0.0 -0.0
Number of live births 1.6 2.3 2.9 -0.9 1.6 1.7 1.7
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 3.1 1.8 -0.8 -1.2 0.8
Pulse rate 0.9 1.4 2.9 1.0 1.2 -0.6 -1.7
Happiness 1.3 1.6 6.1 -0.1 -2.5 0.6 0.2
Noisy workplace 0.4 0.4 1.5 -0.2 0.1 0.5 1.2
Qualifications: A levels/AS levels or equivalent 0.6 1.4 2.2 1.3 0.7 -1.2 -1.5
Serious illness, injury or assault of a close relative in last 2 years 1.7 1.9 4.4 -2.1 -1.0 0.5 -1.4
Mouth/teeth dental problems: Dentures 0.4 0.7 1.1 0.9 -1.1 -0.8 0.1
Asthma 1.1 2.2 5.8 -2.4 -0.6 1.3 -1.0
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 1.0 0.9 -1.0 -0.2 0.9
Medication: Cholesterol lowering 1.3 2.0 3.9 -2.0 1.1 -0.1 -1.8
Depression (self-reported) 2.1 2.5 5.3 -2.3 -0.1 1.2 -1.8
Medication: Lansoprazole 1.1 1.3 3.4 -1.8 -1.3 -0.2 -0.2
Prospective memory result 1.7 2.0 6.7 -0.5 2.6 1.0 0.4
Lung cancer (father) 1.0 1.2 3.3 -0.5 -0.8 0.7 1.8
Illnesses of mother 0.2 0.2 0.4 -0.2 -0.6 -0.6 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 1.9 1.1 -0.8 -1.4 0.6
Pulse wave Arterial Stiffness index 0.1 0.1 0.3 -0.6 -0.4 0.0 -0.3
Impedance of arm (left) 0.6 2.9 10.3 0.9 3.2 0.7 0.2
Arm fat mass (right) 0.8 3.5 8.2 -2.9 -2.1 -0.8 0.7
Trunk predicted mass 1.6 9.1 20.8 1.9 -4.6 -3.5 -0.2
Standing height 1.2 11.9 22.4 4.7 -2.7 -4.1 -1.0
Length of working week for main job 0.4 0.4 1.3 0.2 -0.6 0.3 1.1
Exposure to tobacco smoke at home 1.5 1.7 3.5 -0.7 1.4 -1.0 1.9
Breastfed as a baby 0.8 0.9 2.1 0.5 -0.5 -1.1 1.5
Tense / ‘highly strung’ 1.9 3.1 6.7 -2.6 -0.8 2.0 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 3.2 -1.8 -0.7 0.3 -1.1
Hair/balding pattern: Pattern 4 0.6 1.5 3.4 -0.1 -1.5 -0.1 1.9
Birth weight of first child 0.5 0.8 2.0 0.1 -1.0 0.4 -1.4
Peak expiratory flow (PEF) 0.3 0.7 2.0 0.1 1.4 -0.8 0.0
Pulse wave reflection index 0.8 1.0 2.8 -1.7 -0.7 0.5 -0.5
Ever highly irritable/argumentative for 2 days 0.7 0.9 1.9 1.1 -1.4 -0.1 0.6
Loud music exposure frequency 0.3 0.3 0.8 -0.2 -0.3 -0.5 -0.9
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 4.4 2.1 0.1 0.2 -0.0
Mouth/teeth dental problems: Bleeding gums 2.8 3.7 7.1 -2.2 1.1 2.7 -1.2
Blood clot in the leg (DVT) 1.4 1.9 4.9 -2.2 1.4 0.8 0.1
Medication: Paracetamol 0.1 0.2 0.4 0.4 0.1 0.3 0.6
Headache pain in last month 0.9 1.5 2.9 -1.4 -0.1 -1.0 -1.7
Medication for cholesterol, blood pressure or diabetes 1.7 2.9 4.9 2.1 -1.4 0.3 2.2
Glaucoma (self-reported) 0.4 0.5 0.9 0.5 0.9 0.4 -1.0
Gout (self-reported) 0.8 1.1 2.8 0.1 1.0 -1.7 -0.9
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 4.8 0.4 0.1 -2.2 0.5
Medication: Amlodipine 0.7 1.0 1.6 -1.0 1.3 1.1 0.2
Medication: Ventolin 100micrograms inhaler 1.1 1.4 2.4 -1.6 -0.4 1.2 -1.3
Birth weight 0.6 1.2 2.6 0.8 1.6 0.4 -1.2
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.8 0.8 0.1 0.3 -0.9
High blood pressure (siblings) 0.7 1.0 2.0 -1.2 0.4 1.4 0.7
Forced vital capacity (FVC), Best measure 0.7 2.5 4.0 1.6 -2.0 -1.5 1.2
Body fat percentage 1.3 4.9 18.4 -4.3 -1.0 0.2 0.7
Leg fat percentage (right) 1.3 4.7 17.9 -4.2 -0.8 -0.0 0.5
Arm fat-free mass (right) 1.4 7.3 18.5 1.3 -4.3 -3.0 0.3
Exposure to tobacco smoke outside home 0.5 0.6 1.9 -1.4 0.1 0.8 -0.2
Comparative body size at age 10 0.5 1.2 1.9 1.4 1.2 1.1 0.6
Number of full brothers 0.5 0.6 1.3 0.0 -0.9 -1.1 0.5
Worry too long after embarrassment 0.9 1.6 5.9 0.0 -2.4 0.2 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 2.0 -1.4 -0.6 0.3 -0.7
Wheeze or whistling in the chest in last year 0.4 0.8 1.9 -0.9 0.3 -0.4 -1.4
Number of children fathered 0.9 1.0 3.7 -0.3 -0.3 -0.1 -1.9
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.7 -0.9 -1.3 -0.0 0.6
Age at first live birth 1.5 2.7 7.3 -0.1 1.0 -1.6 -2.7
Pulse wave peak to peak time 0.2 0.2 0.7 0.8 0.2 -0.1 -0.1
Health satisfaction 0.6 0.8 2.2 -1.5 0.3 -0.9 0.1
Shortness of breath walking on level ground 0.7 0.9 2.9 -0.6 -1.7 0.2 0.5
Qualifications: College or University degree 0.3 1.1 3.0 1.7 0.9 -0.1 -0.7
Eye problems/disorders: None of the above 3.1 3.6 6.7 -1.8 1.4 2.6 -1.5
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.8 0.9 0.1 -0.3 0.0
Emphysema/chronic bronchitis 0.2 0.2 0.5 0.2 0.3 -0.7 -0.3
Medication for pain relief, constipation, heartburn 0.2 0.4 1.1 -0.1 -0.4 1.1 0.5
Neck or shoulder pain in last month 0.8 1.1 2.1 -1.5 -0.9 -0.4 -1.1
Medication: Blood pressure 1.9 3.4 6.2 -2.1 2.5 0.8 -1.6
Angina (self-reported) 1.3 1.7 4.1 -0.7 2.0 -1.1 -1.0
Migraine (self-reported) 1.3 1.6 3.5 -0.6 0.7 -1.9 -1.5
Medication: Ibuprofen 0.5 0.6 0.9 0.9 -0.7 -0.6 0.8
Medication: Allopurinol 2.2 3.0 4.6 1.7 1.8 -2.1 -1.1
Medication: Omeprazole 0.5 0.6 1.0 -1.0 0.8 -0.0 -0.9
Medication: Seretide 50 evohaler 0.4 0.5 1.8 0.0 0.2 0.1 -1.4
Mean time to correctly identify matches 0.6 1.2 2.9 1.4 -1.7 -0.1 -0.0
Heart disease (mother) 0.8 0.9 2.7 -1.6 0.2 -1.0 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.4 0.2 -0.4 0.5 -0.7
Whole body fat mass 0.8 3.5 7.5 -2.7 -2.2 -1.1 0.6
Leg fat mass (right) 0.9 3.4 8.0 -2.8 -2.1 -1.1 0.4
Arm predicted mass (right) 1.5 7.6 18.0 1.5 -4.2 -3.2 0.4
Pulse rate, automated reading 0.5 1.6 4.1 -1.0 2.0 0.2 -1.3
Alcohol intake frequency. 0.3 0.7 2.6 -0.1 -0.3 1.6 0.3
Comparative height size at age 10 0.9 4.9 7.6 2.8 -2.0 -2.6 -1.0
Number of full sisters 3.9 4.7 10.8 0.5 -2.7 -0.8 3.3
Suffer from ‘nerves’ 1.9 3.0 6.5 -2.2 0.2 2.5 -1.0
Overall health rating 0.6 1.3 2.4 -1.5 0.0 0.9 1.4
Chest pain or discomfort 0.8 1.1 2.5 -1.6 -0.4 0.9 -1.0
Had major operations 0.2 0.2 0.4 0.6 -0.1 -0.6 -0.3
Age at last live birth 1.1 1.6 4.1 0.5 1.4 -0.4 -2.0
Family relationship satisfaction 1.2 1.5 5.8 0.1 -2.4 0.2 0.4
Leg pain on walking 0.8 1.0 1.7 -1.3 -0.8 -0.5 1.3
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.8 1.5 0.8 -0.6 -0.8 1.2
Commuting to job workplace: Car/motor vehicle 1.2 1.3 3.9 0.2 2.0 0.4 -1.1
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 1.6 1.2 1.2 -0.4 0.0
Medication: Aspirin 2.0 2.6 3.4 -1.2 1.6 -1.8 -1.8
Supplements: Vitamin C 0.8 1.0 2.5 0.1 0.5 -1.1 -1.6
Knee pain experienced in last month 2.2 3.4 10.0 0.1 -3.2 -0.3 1.8
Hypertension (Self-reported) 1.1 3.0 9.8 -3.1 1.1 -1.0 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.9 -1.4 -0.3 -0.4 0.4
Illnesses of father: Heart disease 0.2 0.2 0.4 -0.6 -0.4 0.3 0.5
Illnesses of siblings: Diabetes 0.5 0.6 1.7 -1.3 -0.3 0.6 0.1
Smoking status: Previous 0.6 1.0 1.8 1.0 -1.4 0.2 1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 4.6 0.2 -1.4 -0.2 -2.1
Whole body fat-free mass 1.3 7.4 19.5 1.4 -4.4 -2.9 -0.0
Leg fat-free mass (right) 1.0 5.1 14.5 1.1 -3.8 -2.2 0.3
Arm fat percentage (left) 1.1 4.4 15.7 -4.0 -1.2 0.2 0.6
Average weekly red wine intake 2.0 2.9 6.7 2.6 -1.0 -1.6 1.2
Handedness (chirality/laterality): Left-handed 1.9 2.2 5.5 -2.3 -1.5 1.0 -0.5
Mood swings 1.0 1.8 6.3 0.7 -2.5 0.6 -0.5
Loneliness, isolation 1.2 1.6 5.6 -0.6 -2.4 -0.7 0.1
Long-standing illness, disability or infirmity 0.9 1.4 4.2 -2.0 0.2 0.1 -1.2
Ever had bowel cancer screening 1.6 1.9 2.8 -1.7 -1.3 0.6 1.6
Diabetes diagnosed by doctor 1.4 2.2 8.2 -0.5 2.9 0.7 0.2
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 2.4 1.5 1.3 0.3 1.0
Friendships satisfaction 2.5 3.1 9.2 -1.2 -3.0 0.7 -1.1
Qualifications: nursing, teaching 0.8 1.2 2.3 -0.8 1.5 0.3 -1.3
Commuting to job workplace: Walk 0.2 0.2 0.4 0.3 0.7 -0.1 -0.6
Eye problems/disorders: Cataract 2.2 2.5 4.0 1.7 -2.0 -1.7 0.3
Mouth/teeth dental problems: Mouth ulcers 2.9 4.6 7.1 -2.4 -0.2 2.4 -2.7
Medication for cholesterol 0.5 0.8 1.8 1.3 0.9 0.0 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.9 -0.7 0.3 -0.2 -1.0
Back pain experienced in last month 1.8 2.6 5.8 1.0 -2.4 -1.6 0.9
Mineral and other dietary supplements 1.7 2.3 4.5 1.3 2.1 0.4 1.6
Breast cancer (self-reported) 0.6 0.7 1.9 0.2 0.0 -0.8 -1.4
Asthma (self-reported) 1.2 2.4 6.4 -2.5 -0.4 1.3 -1.3
Osteoporosis (self-reported) 0.9 1.1 2.8 -0.8 1.7 0.7 -0.6
Osteoarthritis (self-reported) 0.1 0.1 0.3 -0.0 0.2 0.5 -0.2
Medication: Aspirin 2.4 3.1 4.8 -1.5 1.6 -1.6 -2.2
Medication: Gliclazide 0.5 0.5 1.8 0.4 -0.1 -0.4 1.3
Illnesses of father: None of the above (group 1) 0.0 0.0 0.1 0.4 -0.0 -0.2 -0.1
Smoking status: Current 3.7 5.9 13.3 3.7 0.5 -2.3 2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.8 3.4 -1.0 -1.1 -1.3 1.9
Whole body water mass 1.4 8.0 20.8 1.6 -4.6 -3.0 0.0
Leg predicted mass (right) 0.9 5.0 14.9 1.0 -3.9 -2.0 0.2
Arm fat mass (left) 0.8 3.4 7.5 -2.7 -2.0 -1.0 0.9
Number of self-reported non-cancer illnesses 2.5 4.3 10.1 -3.2 1.3 -0.2 -2.3
Average weekly champagne plus white wine intake 0.5 0.7 2.6 0.1 -0.2 -1.6 -0.3
Miserableness 2.3 4.1 7.2 1.6 -2.7 -0.2 2.5
Guilty feelings 0.5 0.7 1.9 0.6 -1.4 0.6 0.3
Wears glasses or contact lenses 1.0 1.1 2.1 0.6 -1.4 0.3 1.4
Ever taken oral contraceptive pill 0.6 0.6 2.1 -1.4 0.4 0.5 -0.2
Hearing aid user 0.1 0.2 0.3 -0.6 0.2 0.3 -0.5
Mother’s age at death 4.0 5.0 7.8 2.7 -1.6 -1.6 2.8
Financial situation satisfaction 0.9 1.1 3.4 -0.5 -1.8 0.6 -0.5
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.0 0.4 -1.0 -0.4 0.9
Commuting to job workplace: Public transport 0.7 0.8 2.1 0.9 -0.2 -0.6 1.4
Eye problems/disorders: Glaucoma 0.7 0.9 1.7 1.3 1.3 -0.4 0.0
Medication: Blood pressure 0.5 0.9 1.7 -1.3 -0.9 0.1 1.1
Pain type(s) experienced in last month: Hip pain 1.9 2.4 8.2 -1.2 -2.9 -0.2 0.4
Supplements: Fish oil (including cod liver oil) 1.5 1.9 3.0 -1.6 -1.4 0.3 -1.7
High cholesterol (Self-reported) 1.2 2.2 7.8 -2.8 -1.0 -0.1 0.3
Medication: Bendroflumethiazide 0.5 0.7 1.6 -1.0 0.2 -0.2 1.3
Medication: Paracetamol 0.1 0.1 0.4 0.2 0.2 0.2 -0.6
Medication: Lisinopril 0.3 0.3 0.8 -0.6 0.2 -0.9 -0.3
Medication: Atorvastatin 0.7 0.9 1.8 -0.4 -1.1 -0.7 1.3
Illnesses of father: High blood pressure 2.3 2.8 5.3 0.2 2.3 -2.1 -1.3
Alcohol drinker status: Never 0.5 0.7 1.9 -1.4 0.5 0.6 -0.3
Ever smoked 1.9 3.2 7.7 2.8 -1.2 -1.8 0.8
Basal metabolic rate 1.2 6.4 17.8 0.8 -4.2 -2.7 0.0
Leg fat percentage (left) 1.4 5.2 19.8 -4.4 -0.9 0.1 0.6
Arm fat-free mass (left) 1.4 6.9 19.7 0.6 -4.4 -2.7 0.1
Number of operations (self-reported) 0.5 0.7 1.7 0.8 -1.3 -0.6 -0.4
Average weekly beer plus cider intake 1.4 2.0 7.2 -0.9 0.3 -0.0 2.7
Irritability 1.0 1.7 5.4 -0.9 -2.3 0.7 -0.5
Risk taking 2.9 4.2 10.5 2.4 0.4 -3.2 -0.6
Ever had prostate specific antigen (PSA) test 1.4 1.6 3.6 -1.1 0.5 1.1 -1.9
Fractured/broken bones in last 5 years 0.3 0.4 0.8 0.1 0.9 -0.9 0.1
Age started oral contraceptive pill 0.4 0.5 1.0 -1.0 -0.4 0.9 0.4
Diastolic blood pressure, automated reading 0.5 1.6 3.8 -1.9 0.6 -1.0 -1.0
Ever depressed for a whole week 1.1 1.4 3.2 -1.0 -1.0 0.7 -1.8
Unable to work because of sickness or disability 0.1 0.1 0.3 -0.3 -0.2 0.1 -0.5
Commuting to job workplace: Cycle 1.8 2.2 5.2 1.3 0.7 -1.2 2.3
Myopia 0.8 1.2 2.2 -1.5 0.9 1.3 -0.5
Vascular/heart problems diagnosed by doctor 1.0 2.7 7.8 2.8 -1.0 1.2 0.6
Cholesterol lowering medication 1.7 2.5 9.2 -3.0 -0.1 0.6 0.7
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.7 -0.2 0.6 -0.7 -0.8
Pain experienced in last month 0.5 0.9 1.9 0.2 1.4 1.0 -0.7
Supplements: Calcium 0.3 0.3 0.5 -0.4 -0.7 -0.6 -0.4
Basal cell carcinoma (self-reported) 1.5 1.8 3.9 -1.8 0.0 0.3 -2.0
Heart attack/myocardial infarction (self-reported) 1.4 1.9 4.7 -1.5 -0.8 0.0 -2.2
Deep venous thrombosis (DVT) (self-reported) 1.9 2.4 6.0 -2.4 1.6 1.0 0.4
Heart disease (siblings) 0.8 0.9 2.7 -0.3 0.3 -1.7 -0.9
Alcohol drinker status: Previous 1.4 1.6 5.0 1.1 -0.4 0.3 2.2
Pack years of smoking 0.4 0.5 0.9 -0.5 0.9 -0.6 -0.8
Impedance of whole body 0.7 3.7 14.2 0.2 3.8 0.8 -0.3
Leg fat mass (left) 0.9 3.6 8.5 -2.9 -2.2 -1.0 0.5
Arm predicted mass (left) 1.5 7.8 19.7 1.0 -4.4 -3.2 0.1