Hub : Genes

SORBS3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.051	0.0200	0.0018	0.012	0.02	0.008	0.019	0.011	0.0110	0.0015	0.0290	0.0017	0.01500
2	GTEx	Brain Cerebellar Hemisphere	0.232	0.0920	0.0064	0.106	NA	0.065	NA	0.124	0.0011	NA	0.0096	NA	0.00044
3	GTEx	Brain Cerebellum	0.316	0.1240	0.0038	0.007	NA	0.000	NA	0.040	0.1900	NA	0.3300	NA	0.02500
4	GTEx	Nerve Tibial	0.119	0.0474	0.0050	0.013	NA	-0.002	NA	0.008	0.0400	NA	0.4900	NA	0.08700

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	3.1	4.8	9.4	-0.9	2.4	1.8	-3.1
Bipolar Disorder or Schizophrenia	2.2	5.3	10.4	-1.6	1.4	2.5	-3.2
Depressed Affect (Nagel 2018)	2.3	4.9	12.1	0.3	-3.5	-1.2	2.5
Depression (Nagel 2018)	1.1	1.7	3.4	0.6	-1.9	-0.2	1.7
Intelligence (Savage-Jansen 2018)	0.4	1.2	1.9	1.2	-1.4	-1.2	-0.2
Neuroticism (Nagel 2018)	1.2	2.8	6.4	-1.9	-2.5	0.1	1.1
Schizophrenia (2018)	0.7	1.5	2.5	-1.3	-0.1	1.3	-1.6
Schizophrenia vs Biploar Disorder	2.6	3.4	13.0	0.6	-0.6	0.3	3.6
Worry (Nagel 2018)	1.1	2.4	8.6	-2.9	-0.4	0.7	-0.4
Alzheimer’s Disease (in mother)	1.3	1.6	2.7	-0.4	1.0	1.6	-1.5
Alzheimer’s Disease (in father)	0.6	0.7	2.3	0.3	1.5	0.4	0.3
Alzheimer’s Disease (including proxy)	1.3	1.9	4.5	0.2	1.5	2.1	-0.9
Crohns Disease (2017)	0.3	0.7	1.5	-1.2	0.1	1.1	-0.2
Irritable Bowel Disease (IBD)	0.1	0.2	0.7	-0.2	-0.3	0.2	-0.8
Ulcerative Colitis (UC)	0.1	0.2	0.5	0.7	0.1	-0.2	-0.6
Major Depression (MDD)	2.0	2.5	6.7	-1.4	-1.1	0.0	-2.6
Reaction Time	0.9	1.7	3.0	1.7	-1.3	-1.4	0.2
Verbal and Numeric Reasoning (VNR)	1.1	2.7	5.2	0.5	-2.3	-0.8	-2.2
Breast Cancer	1.0	2.3	4.6	-1.5	-2.1	1.4	0.6
Ovarian Cancer	2.1	2.7	5.3	2.3	1.1	-1.8	1.1
Prostate Cancer	0.5	0.7	1.5	-0.9	-0.4	-0.4	1.2
Age at First Birth	1.0	1.5	4.5	-2.1	1.1	-0.0	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.6	2.3	0.2	-0.3	-0.3	1.5
Coronary Artery Disease (CAD)	1.4	1.6	2.9	-0.6	1.6	1.7	-0.7
Crohns Disease (2012)	1.0	1.7	3.0	-1.7	0.9	1.5	-0.8
Mean Putamen Volume	0.1	0.1	0.2	-0.4	0.4	0.3	-0.3
Fasting Glucose	1.0	1.2	3.5	-0.3	-0.2	-1.1	-1.9
HbA1C	0.1	0.1	0.2	-0.5	0.3	0.2	-0.3
HDL Cholesterol	0.4	0.7	1.9	1.4	-0.6	-0.7	0.1
LDL Cholesterol	0.8	1.2	2.4	-0.9	1.2	0.5	1.6
Lupus	2.0	3.0	7.6	-1.8	1.0	2.8	0.6
Neuroticism (2016)	0.4	0.6	1.3	-1.1	-0.6	0.0	0.8
Primary Biliary Cirrhosis	0.4	0.6	1.3	-0.1	0.3	-1.1	1.0
Rheumatoid Arthritis	0.5	0.7	2.0	1.4	-0.1	-0.7	0.7
Schizophrenia (2014)	0.3	0.7	1.5	-1.0	0.4	1.2	-0.5
Triglycerides	0.8	1.3	4.6	-0.4	2.1	-0.2	0.6
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.5	-1.2	-1.2	0.4	-0.7
Ulcerative Colitis	0.7	1.1	2.8	1.7	0.1	-0.6	1.1
Blood Eosinophil Count	0.9	7.3	12.8	3.6	2.2	-2.8	-1.9
Blood Platelet Count	1.5	17.7	59.1	-2.0	7.7	-1.2	-2.6
Blood Red Count	0.4	3.8	10.0	3.2	-1.2	-1.7	0.8
Blood White Count	0.5	3.7	9.1	0.8	3.0	-1.9	-1.2
Heel T-Score	0.2	1.2	3.3	-0.4	-1.1	-1.8	-0.2
BMI	0.4	2.5	4.1	-2.0	-1.8	-1.4	0.8
Height	0.6	11.8	18.8	4.3	-3.5	-3.9	-1.2
Waist Hip Ratio (WHR)	0.5	2.4	6.1	1.6	2.5	-0.8	0.2
Systolic Blood Pressure	1.4	6.8	20.0	-2.2	4.5	0.3	-1.5
Smoking Status	5.0	12.0	23.6	4.9	-1.7	-3.2	3.3
Allergy or Eczema	2.9	7.8	16.9	-3.5	1.0	1.0	-4.1
Cardiovascular Disease	1.5	4.9	15.2	-3.9	1.3	-1.4	-0.9
Hypothyroidism (self reported)	0.6	1.3	5.1	0.2	0.0	-2.3	0.4
Respiratory disease	0.2	0.5	1.1	-0.7	-1.1	0.2	-0.6
Type 2 Diabetes (T2D) (2018)	1.3	2.4	8.9	-0.3	3.0	0.8	-0.0
Lung FEV1/FVC ratio	1.2	6.1	20.3	-1.4	4.5	-0.9	-1.2
Lung FVC	1.5	7.9	20.6	0.4	-4.5	0.9	3.2
Neuroticism	1.4	3.5	12.6	-0.7	-3.6	-0.3	0.8
Chronotype (morning person)	0.2	0.5	1.7	0.5	0.3	-0.1	1.3
Hair Pigment	0.5	13.8	31.1	-5.6	-2.3	0.3	-4.3
Tanning	0.2	2.2	6.6	2.6	0.2	-1.5	0.2
Hand grip strength (left)	1.3	3.5	7.5	2.3	-1.0	-2.7	-0.5
Number of treatments/medications taken	2.5	4.4	9.4	-3.1	1.7	0.6	-2.2
Average weekly spirits intake	0.8	1.0	2.4	-1.6	-0.6	-1.0	0.5
Sensitivity / hurt feelings	1.2	2.0	5.9	-2.4	0.4	1.2	-0.7
Frequency of depressed mood in last 2 weeks	0.8	1.1	3.1	1.1	-1.8	0.0	0.3
Hearing difficulty/problems: Yes	1.0	1.5	5.1	-0.1	-2.3	-0.2	0.8
Relative age of first facial hair	0.7	1.5	2.3	-0.6	1.5	1.5	-1.0
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.2	-0.7	-1.5	-0.8	1.2
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.9	-1.7	0.1	0.1	-0.2
Ever had hysterectomy (womb removed)	0.6	0.6	1.9	-1.4	0.0	-0.7	0.3
Systolic blood pressure, automated reading	1.2	3.5	11.8	-3.4	1.0	0.7	-0.8
Eye problems/disorders: Diabetes related eye disease	1.2	1.4	3.9	0.8	2.0	0.0	1.0
Angina	1.4	1.8	4.2	-0.6	2.1	-1.4	-0.9
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.2	0.2	0.5	-0.3
Vitamin and mineral supplements	1.3	1.7	4.6	1.4	-0.7	0.1	2.1
Supplements: Zinc	0.4	0.5	1.3	-0.3	0.3	1.1	-0.6
Medication: Co-codamol	1.6	1.8	4.3	-0.0	1.4	1.0	2.1
Medication: Metformin	1.5	2.1	3.6	-1.3	1.9	1.8	-0.2
Diabetes (father)	2.0	2.5	4.3	-1.1	2.1	1.5	-1.5
Diabetes (mother)	0.9	1.2	2.8	0.8	1.7	0.6	1.0
Severe depression (siblings)	0.4	0.4	1.1	0.5	-0.5	-1.1	-0.0
Pack years adult smoking proportion	0.3	0.5	0.9	-0.5	1.0	-0.3	-0.7
Impedance of leg (right)	0.7	3.5	12.6	-0.6	3.5	0.4	-0.8
Leg fat-free mass (left)	1.0	5.2	14.2	1.0	-3.8	-2.3	0.2
Trunk fat percentage	1.0	3.9	14.3	-3.8	-0.8	-0.0	0.9
Hand grip strength (right)	1.7	4.7	12.6	3.5	-1.3	-2.2	-0.1
Townsend deprivation index at recruitment	0.8	1.1	2.6	0.7	-1.6	-0.1	1.2
Current tobacco smoking	3.5	5.8	14.7	3.8	0.1	-2.3	1.8
Average weekly fortified wine intake	0.4	0.4	1.0	0.2	-1.0	0.0	-0.8
Maternal smoking around birth	1.9	2.7	5.8	-1.7	-0.2	2.4	1.5
Fed-up feelings	0.9	1.6	5.3	-0.4	-2.3	0.8	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	3.9	1.5	-2.0	0.0	1.3
Relative age voice broke	0.6	1.0	2.1	-1.4	0.9	0.6	-0.9
Taking other prescription medications	2.1	3.2	9.5	-3.1	1.2	0.1	-1.4
Age when periods started (menarche)	0.3	0.7	1.3	0.6	1.1	-0.0	-1.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.4	0.2	0.3	0.0	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.9	0.4	-0.1	-1.0	0.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.9	-0.5	0.8	-0.3	-1.0
Qualifications: CSEs or equivalent	0.2	0.3	0.5	0.2	-0.2	0.7	0.7
Serious illness, injury or assault to yourself	0.6	0.8	2.9	0.1	-1.7	0.4	0.1
High blood pressure	1.1	3.2	10.4	-3.2	1.2	-0.7	-0.6
Hayfever, allergic rhinitis or eczema	4.9	10.7	18.2	-4.3	1.6	2.0	-4.2
Multivitamins +/- minerals	0.9	1.2	3.1	-1.2	0.0	0.6	-1.8
Stomach or abdominal pain in last month	0.6	0.8	1.6	-0.0	-1.3	-1.2	-0.2
Supplements: Glucosamine	0.3	0.4	1.3	-0.0	-0.4	-1.2	-0.5
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.2	-1.1	1.1	0.3	-0.4
Medication: Atenolol	0.4	0.5	1.7	0.2	1.3	-0.5	-0.4
Medication: Levothyroxine sodium	1.2	2.1	7.1	0.6	0.2	-2.7	1.0
Sitting height	0.3	1.8	3.2	1.8	-1.0	-1.7	-0.4
Chronic bronchitis/emphysema (father)	1.4	1.6	3.5	-1.5	-1.9	0.4	-0.7
High blood pressure (mother)	0.9	1.2	3.5	-0.1	0.9	0.8	1.9
Body mass index (BMI)	1.0	4.2	12.2	-3.5	-1.9	-0.2	1.0
Impedance of leg (left)	0.7	3.2	12.0	-0.7	3.5	0.5	-0.4
Leg predicted mass (left)	1.0	5.2	14.4	1.0	-3.8	-2.3	0.2
Trunk fat mass	0.8	3.3	8.1	-2.8	-2.0	-1.0	0.6
Waist circumference	0.5	1.8	3.2	-1.8	-1.7	-0.9	0.6
Number of incorrect matches in round	0.7	1.2	2.8	-0.5	1.7	1.1	0.9
Past tobacco smoking	1.3	2.5	3.7	-1.9	1.6	1.3	-1.3
Alcohol usually taken with meals	0.4	0.7	2.1	1.4	-0.0	0.2	-0.9
Nervous feelings	0.8	1.5	4.0	-2.0	0.2	1.2	-0.7
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	4.6	-0.2	-1.8	2.2	-0.9
Hearing difficulty/problems with background noise	1.2	2.0	5.8	-1.4	-2.4	0.1	0.5
Hair/balding pattern: Pattern 2	0.8	1.1	1.7	-1.2	-1.3	1.0	-0.4
Had menopause	0.5	0.7	2.3	-1.5	0.1	0.2	0.6
Had other major operations	1.8	2.2	3.9	-0.5	1.8	1.2	-2.0
Forced vital capacity (FVC)	1.1	4.2	7.2	2.5	-2.7	-1.2	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.1	0.3	0.1	-0.3	0.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.3	0.0	-1.5	0.3	-1.5
Qualifications: None of the above	0.2	0.5	1.5	-0.0	-1.2	-0.4	0.6
Financial difficulties in last 2 years	0.8	1.0	1.8	-1.4	-1.1	0.1	-1.0
Mouth/teeth dental problems	0.7	1.1	1.9	0.7	-0.5	-1.4	1.3
Heart attack	1.8	2.3	6.0	-1.7	-0.6	0.1	-2.5
Allergy	3.6	8.3	17.6	3.6	-1.3	-0.8	4.2
Pain all over the body in last month	0.0	0.0	0.1	-0.3	0.2	-0.1	-0.1
Diabetes (self-reported)	1.0	1.6	6.1	0.3	2.5	0.0	0.3
Hayfever/allergic rhinitis (self-reported)	2.0	2.6	5.1	-2.3	-0.2	0.9	-2.1
Medication: Ramipril	1.3	1.6	4.3	-1.2	2.1	0.6	-0.6
Medication: Simvastatin	2.2	3.2	9.4	-3.1	1.2	1.1	-0.9
Fluid intelligence score	1.4	2.9	6.1	0.4	-2.2	-0.6	-2.5
Illnesses of siblings	0.4	0.5	0.8	0.7	-0.9	-0.1	0.8
Neuroticism score	1.0	2.0	6.7	-0.7	-2.6	0.9	0.3
Weight	0.8	3.8	9.7	-1.1	-3.1	-2.0	0.4
Impedance of arm (right)	0.5	2.5	8.7	0.0	2.9	0.9	-0.7
Arm fat percentage (right)	1.3	4.9	18.2	-4.3	-1.2	0.4	0.2
Trunk fat-free mass	1.6	8.9	21.1	1.8	-4.6	-3.4	-0.3
Hip circumference	0.9	4.0	9.6	-2.3	-3.1	-0.9	0.5
Time employed in main current job	0.3	0.3	1.0	-0.4	-0.2	-1.0	0.3
Alcohol intake versus 10 years previously	0.4	0.6	1.5	-1.2	0.8	0.4	-0.1
Father’s age at death	0.4	0.5	1.1	1.0	0.2	0.8	0.5
Worrier / anxious feelings	0.5	0.9	2.0	-1.4	1.1	0.4	-0.3
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.4	5.4	-2.3	-2.3	1.6	-0.5
Falls in the last year	0.7	1.0	2.3	-0.2	-1.0	-1.5	-0.7
Hair/balding pattern: Pattern 3	1.0	1.5	4.7	2.2	1.1	-0.0	-0.0
Number of live births	1.6	2.3	2.9	-0.9	1.6	1.7	1.7
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	3.1	1.8	-0.8	-1.2	0.8
Pulse rate	0.9	1.4	2.9	1.0	1.2	-0.6	-1.7
Happiness	1.3	1.6	6.1	-0.1	-2.5	0.6	0.2
Noisy workplace	0.4	0.4	1.5	-0.2	0.1	0.5	1.2
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.2	1.3	0.7	-1.2	-1.5
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	4.4	-2.1	-1.0	0.5	-1.4
Mouth/teeth dental problems: Dentures	0.4	0.7	1.1	0.9	-1.1	-0.8	0.1
Asthma	1.1	2.2	5.8	-2.4	-0.6	1.3	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.0	0.9	-1.0	-0.2	0.9
Medication: Cholesterol lowering	1.3	2.0	3.9	-2.0	1.1	-0.1	-1.8
Depression (self-reported)	2.1	2.5	5.3	-2.3	-0.1	1.2	-1.8
Medication: Lansoprazole	1.1	1.3	3.4	-1.8	-1.3	-0.2	-0.2
Prospective memory result	1.7	2.0	6.7	-0.5	2.6	1.0	0.4
Lung cancer (father)	1.0	1.2	3.3	-0.5	-0.8	0.7	1.8
Illnesses of mother	0.2	0.2	0.4	-0.2	-0.6	-0.6	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	1.9	1.1	-0.8	-1.4	0.6
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	-0.6	-0.4	0.0	-0.3
Impedance of arm (left)	0.6	2.9	10.3	0.9	3.2	0.7	0.2
Arm fat mass (right)	0.8	3.5	8.2	-2.9	-2.1	-0.8	0.7
Trunk predicted mass	1.6	9.1	20.8	1.9	-4.6	-3.5	-0.2
Standing height	1.2	11.9	22.4	4.7	-2.7	-4.1	-1.0
Length of working week for main job	0.4	0.4	1.3	0.2	-0.6	0.3	1.1
Exposure to tobacco smoke at home	1.5	1.7	3.5	-0.7	1.4	-1.0	1.9
Breastfed as a baby	0.8	0.9	2.1	0.5	-0.5	-1.1	1.5
Tense / ‘highly strung’	1.9	3.1	6.7	-2.6	-0.8	2.0	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.2	-1.8	-0.7	0.3	-1.1
Hair/balding pattern: Pattern 4	0.6	1.5	3.4	-0.1	-1.5	-0.1	1.9
Birth weight of first child	0.5	0.8	2.0	0.1	-1.0	0.4	-1.4
Peak expiratory flow (PEF)	0.3	0.7	2.0	0.1	1.4	-0.8	0.0
Pulse wave reflection index	0.8	1.0	2.8	-1.7	-0.7	0.5	-0.5
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.9	1.1	-1.4	-0.1	0.6
Loud music exposure frequency	0.3	0.3	0.8	-0.2	-0.3	-0.5	-0.9
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	4.4	2.1	0.1	0.2	-0.0
Mouth/teeth dental problems: Bleeding gums	2.8	3.7	7.1	-2.2	1.1	2.7	-1.2
Blood clot in the leg (DVT)	1.4	1.9	4.9	-2.2	1.4	0.8	0.1
Medication: Paracetamol	0.1	0.2	0.4	0.4	0.1	0.3	0.6
Headache pain in last month	0.9	1.5	2.9	-1.4	-0.1	-1.0	-1.7
Medication for cholesterol, blood pressure or diabetes	1.7	2.9	4.9	2.1	-1.4	0.3	2.2
Glaucoma (self-reported)	0.4	0.5	0.9	0.5	0.9	0.4	-1.0
Gout (self-reported)	0.8	1.1	2.8	0.1	1.0	-1.7	-0.9
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	4.8	0.4	0.1	-2.2	0.5
Medication: Amlodipine	0.7	1.0	1.6	-1.0	1.3	1.1	0.2
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.4	-1.6	-0.4	1.2	-1.3
Birth weight	0.6	1.2	2.6	0.8	1.6	0.4	-1.2
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.8	0.8	0.1	0.3	-0.9
High blood pressure (siblings)	0.7	1.0	2.0	-1.2	0.4	1.4	0.7
Forced vital capacity (FVC), Best measure	0.7	2.5	4.0	1.6	-2.0	-1.5	1.2
Body fat percentage	1.3	4.9	18.4	-4.3	-1.0	0.2	0.7
Leg fat percentage (right)	1.3	4.7	17.9	-4.2	-0.8	-0.0	0.5
Arm fat-free mass (right)	1.4	7.3	18.5	1.3	-4.3	-3.0	0.3
Exposure to tobacco smoke outside home	0.5	0.6	1.9	-1.4	0.1	0.8	-0.2
Comparative body size at age 10	0.5	1.2	1.9	1.4	1.2	1.1	0.6
Number of full brothers	0.5	0.6	1.3	0.0	-0.9	-1.1	0.5
Worry too long after embarrassment	0.9	1.6	5.9	0.0	-2.4	0.2	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.0	-1.4	-0.6	0.3	-0.7
Wheeze or whistling in the chest in last year	0.4	0.8	1.9	-0.9	0.3	-0.4	-1.4
Number of children fathered	0.9	1.0	3.7	-0.3	-0.3	-0.1	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.7	-0.9	-1.3	-0.0	0.6
Age at first live birth	1.5	2.7	7.3	-0.1	1.0	-1.6	-2.7
Pulse wave peak to peak time	0.2	0.2	0.7	0.8	0.2	-0.1	-0.1
Health satisfaction	0.6	0.8	2.2	-1.5	0.3	-0.9	0.1
Shortness of breath walking on level ground	0.7	0.9	2.9	-0.6	-1.7	0.2	0.5
Qualifications: College or University degree	0.3	1.1	3.0	1.7	0.9	-0.1	-0.7
Eye problems/disorders: None of the above	3.1	3.6	6.7	-1.8	1.4	2.6	-1.5
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.8	0.9	0.1	-0.3	0.0
Emphysema/chronic bronchitis	0.2	0.2	0.5	0.2	0.3	-0.7	-0.3
Medication for pain relief, constipation, heartburn	0.2	0.4	1.1	-0.1	-0.4	1.1	0.5
Neck or shoulder pain in last month	0.8	1.1	2.1	-1.5	-0.9	-0.4	-1.1
Medication: Blood pressure	1.9	3.4	6.2	-2.1	2.5	0.8	-1.6
Angina (self-reported)	1.3	1.7	4.1	-0.7	2.0	-1.1	-1.0
Migraine (self-reported)	1.3	1.6	3.5	-0.6	0.7	-1.9	-1.5
Medication: Ibuprofen	0.5	0.6	0.9	0.9	-0.7	-0.6	0.8
Medication: Allopurinol	2.2	3.0	4.6	1.7	1.8	-2.1	-1.1
Medication: Omeprazole	0.5	0.6	1.0	-1.0	0.8	-0.0	-0.9
Medication: Seretide 50 evohaler	0.4	0.5	1.8	0.0	0.2	0.1	-1.4
Mean time to correctly identify matches	0.6	1.2	2.9	1.4	-1.7	-0.1	-0.0
Heart disease (mother)	0.8	0.9	2.7	-1.6	0.2	-1.0	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	0.2	-0.4	0.5	-0.7
Whole body fat mass	0.8	3.5	7.5	-2.7	-2.2	-1.1	0.6
Leg fat mass (right)	0.9	3.4	8.0	-2.8	-2.1	-1.1	0.4
Arm predicted mass (right)	1.5	7.6	18.0	1.5	-4.2	-3.2	0.4
Pulse rate, automated reading	0.5	1.6	4.1	-1.0	2.0	0.2	-1.3
Alcohol intake frequency.	0.3	0.7	2.6	-0.1	-0.3	1.6	0.3
Comparative height size at age 10	0.9	4.9	7.6	2.8	-2.0	-2.6	-1.0
Number of full sisters	3.9	4.7	10.8	0.5	-2.7	-0.8	3.3
Suffer from ‘nerves’	1.9	3.0	6.5	-2.2	0.2	2.5	-1.0
Overall health rating	0.6	1.3	2.4	-1.5	0.0	0.9	1.4
Chest pain or discomfort	0.8	1.1	2.5	-1.6	-0.4	0.9	-1.0
Had major operations	0.2	0.2	0.4	0.6	-0.1	-0.6	-0.3
Age at last live birth	1.1	1.6	4.1	0.5	1.4	-0.4	-2.0
Family relationship satisfaction	1.2	1.5	5.8	0.1	-2.4	0.2	0.4
Leg pain on walking	0.8	1.0	1.7	-1.3	-0.8	-0.5	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.5	0.8	-0.6	-0.8	1.2
Commuting to job workplace: Car/motor vehicle	1.2	1.3	3.9	0.2	2.0	0.4	-1.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.6	1.2	1.2	-0.4	0.0
Medication: Aspirin	2.0	2.6	3.4	-1.2	1.6	-1.8	-1.8
Supplements: Vitamin C	0.8	1.0	2.5	0.1	0.5	-1.1	-1.6
Knee pain experienced in last month	2.2	3.4	10.0	0.1	-3.2	-0.3	1.8
Hypertension (Self-reported)	1.1	3.0	9.8	-3.1	1.1	-1.0	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.9	-1.4	-0.3	-0.4	0.4
Illnesses of father: Heart disease	0.2	0.2	0.4	-0.6	-0.4	0.3	0.5
Illnesses of siblings: Diabetes	0.5	0.6	1.7	-1.3	-0.3	0.6	0.1
Smoking status: Previous	0.6	1.0	1.8	1.0	-1.4	0.2	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	4.6	0.2	-1.4	-0.2	-2.1
Whole body fat-free mass	1.3	7.4	19.5	1.4	-4.4	-2.9	-0.0
Leg fat-free mass (right)	1.0	5.1	14.5	1.1	-3.8	-2.2	0.3
Arm fat percentage (left)	1.1	4.4	15.7	-4.0	-1.2	0.2	0.6
Average weekly red wine intake	2.0	2.9	6.7	2.6	-1.0	-1.6	1.2
Handedness (chirality/laterality): Left-handed	1.9	2.2	5.5	-2.3	-1.5	1.0	-0.5
Mood swings	1.0	1.8	6.3	0.7	-2.5	0.6	-0.5
Loneliness, isolation	1.2	1.6	5.6	-0.6	-2.4	-0.7	0.1
Long-standing illness, disability or infirmity	0.9	1.4	4.2	-2.0	0.2	0.1	-1.2
Ever had bowel cancer screening	1.6	1.9	2.8	-1.7	-1.3	0.6	1.6
Diabetes diagnosed by doctor	1.4	2.2	8.2	-0.5	2.9	0.7	0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.4	1.5	1.3	0.3	1.0
Friendships satisfaction	2.5	3.1	9.2	-1.2	-3.0	0.7	-1.1
Qualifications: nursing, teaching	0.8	1.2	2.3	-0.8	1.5	0.3	-1.3
Commuting to job workplace: Walk	0.2	0.2	0.4	0.3	0.7	-0.1	-0.6
Eye problems/disorders: Cataract	2.2	2.5	4.0	1.7	-2.0	-1.7	0.3
Mouth/teeth dental problems: Mouth ulcers	2.9	4.6	7.1	-2.4	-0.2	2.4	-2.7
Medication for cholesterol	0.5	0.8	1.8	1.3	0.9	0.0	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.9	-0.7	0.3	-0.2	-1.0
Back pain experienced in last month	1.8	2.6	5.8	1.0	-2.4	-1.6	0.9
Mineral and other dietary supplements	1.7	2.3	4.5	1.3	2.1	0.4	1.6
Breast cancer (self-reported)	0.6	0.7	1.9	0.2	0.0	-0.8	-1.4
Asthma (self-reported)	1.2	2.4	6.4	-2.5	-0.4	1.3	-1.3
Osteoporosis (self-reported)	0.9	1.1	2.8	-0.8	1.7	0.7	-0.6
Osteoarthritis (self-reported)	0.1	0.1	0.3	-0.0	0.2	0.5	-0.2
Medication: Aspirin	2.4	3.1	4.8	-1.5	1.6	-1.6	-2.2
Medication: Gliclazide	0.5	0.5	1.8	0.4	-0.1	-0.4	1.3
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	0.4	-0.0	-0.2	-0.1
Smoking status: Current	3.7	5.9	13.3	3.7	0.5	-2.3	2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	3.4	-1.0	-1.1	-1.3	1.9
Whole body water mass	1.4	8.0	20.8	1.6	-4.6	-3.0	0.0
Leg predicted mass (right)	0.9	5.0	14.9	1.0	-3.9	-2.0	0.2
Arm fat mass (left)	0.8	3.4	7.5	-2.7	-2.0	-1.0	0.9
Number of self-reported non-cancer illnesses	2.5	4.3	10.1	-3.2	1.3	-0.2	-2.3
Average weekly champagne plus white wine intake	0.5	0.7	2.6	0.1	-0.2	-1.6	-0.3
Miserableness	2.3	4.1	7.2	1.6	-2.7	-0.2	2.5
Guilty feelings	0.5	0.7	1.9	0.6	-1.4	0.6	0.3
Wears glasses or contact lenses	1.0	1.1	2.1	0.6	-1.4	0.3	1.4
Ever taken oral contraceptive pill	0.6	0.6	2.1	-1.4	0.4	0.5	-0.2
Hearing aid user	0.1	0.2	0.3	-0.6	0.2	0.3	-0.5
Mother’s age at death	4.0	5.0	7.8	2.7	-1.6	-1.6	2.8
Financial situation satisfaction	0.9	1.1	3.4	-0.5	-1.8	0.6	-0.5
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.0	0.4	-1.0	-0.4	0.9
Commuting to job workplace: Public transport	0.7	0.8	2.1	0.9	-0.2	-0.6	1.4
Eye problems/disorders: Glaucoma	0.7	0.9	1.7	1.3	1.3	-0.4	0.0
Medication: Blood pressure	0.5	0.9	1.7	-1.3	-0.9	0.1	1.1
Pain type(s) experienced in last month: Hip pain	1.9	2.4	8.2	-1.2	-2.9	-0.2	0.4
Supplements: Fish oil (including cod liver oil)	1.5	1.9	3.0	-1.6	-1.4	0.3	-1.7
High cholesterol (Self-reported)	1.2	2.2	7.8	-2.8	-1.0	-0.1	0.3
Medication: Bendroflumethiazide	0.5	0.7	1.6	-1.0	0.2	-0.2	1.3
Medication: Paracetamol	0.1	0.1	0.4	0.2	0.2	0.2	-0.6
Medication: Lisinopril	0.3	0.3	0.8	-0.6	0.2	-0.9	-0.3
Medication: Atorvastatin	0.7	0.9	1.8	-0.4	-1.1	-0.7	1.3
Illnesses of father: High blood pressure	2.3	2.8	5.3	0.2	2.3	-2.1	-1.3
Alcohol drinker status: Never	0.5	0.7	1.9	-1.4	0.5	0.6	-0.3
Ever smoked	1.9	3.2	7.7	2.8	-1.2	-1.8	0.8
Basal metabolic rate	1.2	6.4	17.8	0.8	-4.2	-2.7	0.0
Leg fat percentage (left)	1.4	5.2	19.8	-4.4	-0.9	0.1	0.6
Arm fat-free mass (left)	1.4	6.9	19.7	0.6	-4.4	-2.7	0.1
Number of operations (self-reported)	0.5	0.7	1.7	0.8	-1.3	-0.6	-0.4
Average weekly beer plus cider intake	1.4	2.0	7.2	-0.9	0.3	-0.0	2.7
Irritability	1.0	1.7	5.4	-0.9	-2.3	0.7	-0.5
Risk taking	2.9	4.2	10.5	2.4	0.4	-3.2	-0.6
Ever had prostate specific antigen (PSA) test	1.4	1.6	3.6	-1.1	0.5	1.1	-1.9
Fractured/broken bones in last 5 years	0.3	0.4	0.8	0.1	0.9	-0.9	0.1
Age started oral contraceptive pill	0.4	0.5	1.0	-1.0	-0.4	0.9	0.4
Diastolic blood pressure, automated reading	0.5	1.6	3.8	-1.9	0.6	-1.0	-1.0
Ever depressed for a whole week	1.1	1.4	3.2	-1.0	-1.0	0.7	-1.8
Unable to work because of sickness or disability	0.1	0.1	0.3	-0.3	-0.2	0.1	-0.5
Commuting to job workplace: Cycle	1.8	2.2	5.2	1.3	0.7	-1.2	2.3
Myopia	0.8	1.2	2.2	-1.5	0.9	1.3	-0.5
Vascular/heart problems diagnosed by doctor	1.0	2.7	7.8	2.8	-1.0	1.2	0.6
Cholesterol lowering medication	1.7	2.5	9.2	-3.0	-0.1	0.6	0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	-0.2	0.6	-0.7	-0.8
Pain experienced in last month	0.5	0.9	1.9	0.2	1.4	1.0	-0.7
Supplements: Calcium	0.3	0.3	0.5	-0.4	-0.7	-0.6	-0.4
Basal cell carcinoma (self-reported)	1.5	1.8	3.9	-1.8	0.0	0.3	-2.0
Heart attack/myocardial infarction (self-reported)	1.4	1.9	4.7	-1.5	-0.8	0.0	-2.2
Deep venous thrombosis (DVT) (self-reported)	1.9	2.4	6.0	-2.4	1.6	1.0	0.4
Heart disease (siblings)	0.8	0.9	2.7	-0.3	0.3	-1.7	-0.9
Alcohol drinker status: Previous	1.4	1.6	5.0	1.1	-0.4	0.3	2.2
Pack years of smoking	0.4	0.5	0.9	-0.5	0.9	-0.6	-0.8
Impedance of whole body	0.7	3.7	14.2	0.2	3.8	0.8	-0.3
Leg fat mass (left)	0.9	3.6	8.5	-2.9	-2.2	-1.0	0.5
Arm predicted mass (left)	1.5	7.8	19.7	1.0	-4.4	-3.2	0.1