Hub : Genes

ALDH18A1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1491	0.0458	3.7e-06	0.082	NA	0.092	NA	0.084	5.2e-07	NA	1.1e-07	NA	4.2e-07
2	GTEx	Brain Cerebellar Hemisphere	0.3100	0.1050	5.7e-04	0.154	NA	0.008	NA	0.066	9.0e-05	NA	2.0e-01	NA	8.9e-03
3	GTEx	Cells Transformed fibroblasts	0.1670	0.0460	3.8e-06	0.046	NA	0.056	NA	0.028	2.3e-04	NA	5.1e-05	NA	3.5e-03
4	GTEx	Esophagus Gastroesophageal Junction	0.1790	0.0770	8.6e-03	-0.008	NA	-0.006	NA	-0.005	8.5e-01	NA	6.4e-01	NA	5.7e-01
5	GTEx	Esophagus Mucosa	0.1610	0.0590	1.6e-03	0.016	NA	0.038	NA	0.057	2.9e-02	NA	1.4e-03	NA	1.2e-04
6	GTEx	Liver	0.2150	0.0690	3.1e-04	0.165	NA	0.159	NA	0.154	2.3e-05	NA	3.4e-05	NA	4.5e-05
7	GTEx	Testis	0.1500	0.0540	1.9e-03	0.003	NA	-0.004	NA	-0.004	2.2e-01	NA	5.6e-01	NA	5.7e-01
8	GTEx	Uterus	0.3720	0.1140	2.2e-03	0.094	NA	0.022	NA	0.040	6.0e-03	NA	1.2e-01	NA	5.4e-02
9	METSIM	Adipose	0.0432	0.0148	5.4e-05	0.049	0.019	0.027	0.016	0.007	6.7e-08	0.00066	5.2e-05	0.0014	2.5e-02
10	YFS	Blood	0.0291	0.0113	4.6e-04	0.002	0.007	0.013	0.010	0.010	7.3e-02	0.00150	2.7e-05	0.0002	2.0e-04
11	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1260	0.0630	2.1e-03	0.023	0.039	0.032	NA	0.040	1.7e-02	0.00260	5.9e-03	NA	2.3e-03
12	TCGA	Lung Squamous Cell Carcinoma	0.0398	0.0216	7.7e-03	0.027	0.005	0.002	NA	0.017	3.9e-04	0.07600	1.9e-01	NA	4.5e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.5	0.8	2.6	0.7	1.2	-0.5	-0.9	-0.6	0.9	-1.0	0.3	0.7	0.5	1.0	1.6
Bipolar Disorder or Schizophrenia	0.4	1.1	5.9	0.5	-0.1	0.7	-0.5	0.2	0.1	0.9	0.1	0.6	2.1	0.6	2.4
Depressed Affect (Nagel 2018)	0.2	0.4	1.8	0.6	1.2	0.4	0.3	0.2	-0.0	-0.1	-0.1	-0.2	0.9	-0.6	1.4
Depression (Nagel 2018)	0.1	0.1	0.8	-0.1	0.2	0.1	-0.3	0.9	-0.4	-0.1	-0.3	-0.2	0.3	0.2	0.5
Intelligence (Savage-Jansen 2018)	1.4	4.2	14.7	-3.3	-3.8	-1.4	0.0	2.0	-2.0	1.7	0.1	-2.2	-2.0	1.0	-1.6
Neuroticism (Nagel 2018)	0.1	0.3	1.2	0.7	0.8	0.3	-0.1	0.3	-0.3	-0.1	-0.9	0.0	1.1	-0.2	0.6
Schizophrenia (2018)	0.6	1.3	5.0	0.1	-1.2	1.4	0.1	0.7	-0.6	1.9	-0.2	0.2	2.2	-0.0	1.8
Schizophrenia vs Biploar Disorder	1.2	1.6	6.2	-0.2	-1.7	1.2	0.6	0.3	-1.3	2.5	-0.7	-0.5	1.8	-1.0	1.1
Worry (Nagel 2018)	0.2	0.4	1.4	0.4	0.5	-1.0	-0.9	0.2	-0.2	-1.2	-0.9	-0.1	0.5	-0.6	-0.4
Alzheimer’s Disease (in mother)	0.2	0.2	1.0	-0.4	-0.2	-0.1	0.1	0.3	-1.0	0.3	0.8	-0.6	-0.1	0.4	0.1
Alzheimer’s Disease (in father)	1.0	1.1	6.5	0.6	-0.5	-0.3	0.1	-0.4	0.7	-0.5	1.0	0.9	-0.2	2.6	1.6
Alzheimer’s Disease (including proxy)	0.4	0.5	3.6	0.2	-0.2	-0.2	0.6	0.1	-0.2	-0.0	1.3	0.3	-0.5	1.9	0.6
Crohns Disease (2017)	1.5	3.2	12.5	-2.1	-2.5	0.3	0.1	0.6	-3.5	1.6	-1.8	-2.8	0.5	-1.0	-0.5
Irritable Bowel Disease (IBD)	0.7	1.7	5.6	-1.3	-1.4	0.6	-0.4	1.4	-2.4	1.3	-1.9	-1.4	1.1	0.2	-0.7
Ulcerative Colitis (UC)	0.2	0.4	2.4	-0.3	-0.2	0.1	-0.5	0.6	-0.4	0.6	-1.5	-0.2	0.3	0.8	-0.8
Major Depression (MDD)	0.8	1.0	4.4	-0.3	-0.6	0.1	-0.6	1.9	-0.1	-0.3	2.1	0.5	1.1	-1.0	0.6
Reaction Time	1.9	3.7	10.2	3.2	2.2	1.8	-1.1	0.0	1.7	-0.1	1.6	2.4	2.0	-0.3	3.0
Verbal and Numeric Reasoning (VNR)	1.9	4.5	13.8	-3.7	-3.7	-1.8	-0.3	1.1	-2.4	1.0	-0.7	-2.7	-2.2	0.0	-1.5
Breast Cancer	0.2	0.5	2.3	0.7	-0.0	1.0	0.4	0.4	0.2	0.7	-0.6	1.5	-0.1	0.8	0.7
Ovarian Cancer	0.3	0.4	1.3	-0.1	0.2	-0.0	-0.6	-0.1	-0.0	1.1	-0.3	-0.3	0.1	-1.1	-1.1
Prostate Cancer	0.7	1.0	4.9	0.6	0.8	-1.0	-1.3	-1.2	0.9	-2.2	0.3	0.3	-0.7	0.4	0.1
Age at First Birth	0.9	1.2	6.1	0.8	0.5	-0.4	0.3	1.2	1.6	-1.0	0.1	1.6	0.1	2.5	0.1
Bipolar Disorder (2011)	1.2	1.1	4.2	-0.0	0.9	-1.7	-1.2	-0.8	1.0	-1.1	2.1	-0.2	-1.1	-0.1	-0.1
Body Mass Index (BMI) (2010)	0.2	0.3	1.6	0.2	-0.0	0.2	0.5	-1.3	-0.3	0.5	0.4	-0.3	0.1	0.6	1.0
Coronary Artery Disease (CAD)	0.6	0.7	3.7	-0.1	0.9	-0.5	0.0	-1.9	0.4	0.0	1.6	0.2	0.3	-0.9	-0.4
Crohns Disease (2012)	1.2	2.0	6.3	-1.5	-1.4	-0.5	0.2	-1.5	-2.1	0.1	-2.5	-2.1	-0.4	-1.4	-0.1
Mean Putamen Volume	0.4	0.4	1.8	-0.6	-0.9	-0.2	0.2	-0.8	0.1	-0.6	-0.2	0.4	0.4	-0.8	1.3
Fasting Glucose	0.6	0.7	2.9	0.1	-0.9	1.0	1.4	1.2	0.1	1.7	0.3	0.2	0.0	0.5	0.3
HbA1C	0.2	0.2	0.6	0.2	0.1	0.1	0.5	0.6	-0.6	0.8	-0.0	0.3	0.2	-0.2	0.5
HDL Cholesterol	0.5	0.8	2.0	1.1	-0.4	1.3	1.1	0.2	1.0	0.8	0.2	1.4	0.6	0.7	0.7
LDL Cholesterol	1.3	2.0	5.8	-2.3	-2.4	-1.9	0.5	-0.4	-2.4	-0.5	0.4	-1.6	-0.1	0.1	-0.0
Lupus	0.7	1.1	3.5	0.8	1.6	0.9	-1.0	1.1	1.9	-0.4	0.3	1.5	0.5	0.8	-0.8
Neuroticism (2016)	1.0	1.5	5.6	-1.2	-1.1	-0.1	1.5	-0.0	-2.1	0.8	-0.8	-2.4	-0.8	-0.8	-0.6
Primary Biliary Cirrhosis	0.4	0.5	1.7	0.7	-0.2	1.0	0.8	-0.4	0.6	0.6	0.6	0.8	0.2	1.3	0.7
Rheumatoid Arthritis	1.4	2.0	4.4	1.4	-0.5	1.1	0.2	2.1	0.7	1.5	0.7	1.7	1.5	1.9	1.9
Schizophrenia (2014)	0.6	1.3	4.5	0.2	-1.6	1.0	-0.2	0.4	-0.6	1.6	0.1	-0.0	2.1	-0.2	2.1
Triglycerides	0.5	0.8	2.8	-1.1	-1.2	0.3	0.5	1.7	-1.1	0.8	1.2	-0.4	0.2	0.4	-0.2
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.8	-0.3	0.6	-0.2	-0.1	-0.7	0.8	0.2	-0.4	-0.3	-0.0	-0.9	-0.9
Ulcerative Colitis	1.0	1.4	4.5	1.5	0.3	1.3	0.5	1.7	1.0	0.7	0.2	1.7	0.9	2.1	0.2
Blood Eosinophil Count	0.3	2.5	9.2	-2.2	-0.6	-0.0	-2.0	3.0	-2.3	1.1	-0.6	-0.9	2.2	0.1	-0.1
Blood Platelet Count	1.1	13.0	51.0	5.3	4.3	2.0	-0.0	-0.5	7.1	1.1	3.4	5.8	0.7	1.8	1.9
Blood Red Count	1.0	9.2	24.8	-0.6	-4.8	3.1	3.1	2.8	-3.4	5.0	-3.4	-1.1	-0.4	3.0	1.4
Blood White Count	0.4	3.2	6.5	2.2	1.5	1.7	-0.5	0.9	2.1	1.6	-0.7	2.5	2.5	0.7	2.5
Heel T-Score	1.0	7.9	30.4	-2.8	-0.7	-5.5	-4.1	-0.5	-1.4	-3.1	0.1	-3.4	-3.6	-0.6	-1.7
BMI	0.3	1.9	6.9	-0.1	-0.7	2.6	-0.2	-1.3	-1.0	2.6	0.8	-0.7	0.5	-1.8	0.9
Height	0.2	4.5	10.1	-2.5	-3.1	0.7	1.9	2.7	-0.5	-0.3	-1.6	0.5	3.2	2.4	-2.8
Waist Hip Ratio (WHR)	0.6	2.6	6.1	1.5	1.4	1.4	1.2	1.4	1.8	1.4	1.7	2.4	1.0	2.5	-0.5
Systolic Blood Pressure	0.4	2.0	4.8	1.4	2.2	2.1	0.5	0.8	1.2	1.7	-1.4	1.9	1.1	-0.2	-0.9
Smoking Status	0.5	1.3	3.4	-0.8	-1.4	0.5	0.5	1.3	-1.9	1.8	0.1	-1.1	0.2	-0.8	1.3
Allergy or Eczema	0.7	1.7	6.1	0.2	1.2	-2.2	-2.5	-1.7	0.9	-1.8	1.0	-0.2	-0.7	-0.2	0.1
Cardiovascular Disease	0.6	1.8	8.8	1.8	3.0	1.6	-0.3	-0.3	1.4	-0.0	-0.4	1.1	0.4	-0.9	-1.7
Hypothyroidism (self reported)	0.1	0.2	0.7	-0.6	-0.1	-0.0	-0.2	-0.4	0.0	0.1	0.8	-0.7	-0.6	0.4	-0.8
Respiratory disease	0.7	1.6	5.7	-1.1	-1.1	-0.3	-1.3	0.6	-0.7	0.5	1.9	0.0	1.7	2.4	1.3
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.5	-0.8	0.8	-0.0	-0.7	-0.1	-0.4	0.9	-0.3	-0.8	0.2	-0.9	-1.2
Lung FEV1/FVC ratio	0.4	2.0	10.1	-0.6	-0.6	-1.5	-1.1	-0.1	0.2	-1.8	-0.8	-1.3	-3.2	-0.1	-1.9
Lung FVC	0.6	3.2	10.9	3.2	3.3	0.8	1.3	0.4	2.7	0.9	-1.5	1.7	-1.2	-0.4	-0.0
Neuroticism	0.2	0.5	1.2	0.8	0.9	-0.0	-0.6	-0.6	-0.2	-0.4	-1.1	-0.1	0.0	-1.1	0.8
Chronotype (morning person)	0.2	0.5	3.7	-0.4	-0.5	-0.3	-0.4	1.9	-0.3	0.3	0.6	-0.0	0.8	0.4	-0.2
Hair Pigment	0.0	0.9	3.3	0.5	1.3	-0.8	-0.6	-1.8	1.3	-0.8	0.4	-0.0	-0.1	-0.9	-1.0
Tanning	0.2	2.5	7.7	2.7	2.2	0.8	-0.4	0.3	2.8	-0.9	1.6	2.4	-0.0	0.4	0.8
Hand grip strength (left)	0.4	1.1	3.8	0.9	-0.3	1.8	1.9	0.6	0.7	0.6	-0.4	1.2	0.5	1.3	-1.0
Number of treatments/medications taken	0.3	0.5	2.0	-0.1	0.1	0.6	-0.4	0.7	-0.2	1.3	0.6	-0.4	1.4	0.4	0.3
Average weekly spirits intake	0.4	0.5	2.3	-0.1	-0.5	0.8	1.5	0.3	-0.8	0.9	0.8	0.2	0.4	0.3	0.3
Sensitivity / hurt feelings	0.1	0.2	0.6	0.5	0.2	0.4	0.4	0.3	-0.8	0.4	0.0	-0.6	-0.3	-0.2	-0.3
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.6	0.9	0.8	0.5	0.8	-1.1	0.6	-0.3	0.2	0.5	0.2	-0.5	1.6
Hearing difficulty/problems: Yes	1.1	1.7	7.8	-0.8	0.5	-0.8	-2.0	-1.4	-0.4	-1.0	0.2	-1.0	-1.0	-2.8	-1.1
Relative age of first facial hair	1.2	2.4	6.6	-2.2	-1.6	1.0	1.5	1.6	-2.6	1.0	-1.0	-0.9	0.9	-0.6	-2.4
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	5.6	0.9	0.6	1.2	1.2	1.3	0.5	2.4	1.6	0.6	1.2	0.0	1.2
Ever used hormone-replacement therapy (HRT)	1.0	1.3	6.0	0.7	-0.6	0.8	-0.3	1.2	-0.3	1.2	-0.1	0.6	2.5	0.3	2.0
Ever had hysterectomy (womb removed)	0.4	0.4	1.4	-0.9	0.2	-0.4	-0.1	-0.1	-1.1	0.6	0.3	-1.2	0.1	-0.6	-0.5
Systolic blood pressure, automated reading	0.7	2.0	6.7	0.7	1.4	2.4	0.8	0.1	-0.0	2.5	0.1	0.9	2.6	-1.0	0.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.2	0.4	0.6	0.3	0.6	0.5	-0.0	1.1	-0.8	-0.1	-1.1	0.0	-0.5
Angina	0.3	0.4	1.8	-0.1	1.0	0.2	0.5	0.5	0.3	-0.6	-0.3	0.3	-0.8	-0.5	-1.3
Medication for hormone replacement therapy	1.6	1.8	5.4	0.0	-1.7	1.1	1.0	2.3	-1.0	1.5	-0.8	-0.0	0.3	2.3	1.3
Vitamin and mineral supplements	1.1	1.5	3.2	-1.2	-1.3	1.0	1.0	1.5	-0.5	1.8	1.4	0.6	1.2	1.3	-1.2
Supplements: Zinc	0.6	0.6	2.5	1.6	1.0	0.5	-0.4	0.1	1.3	-0.3	-0.4	0.8	0.5	0.6	0.9
Medication: Co-codamol	0.9	1.0	3.8	1.3	1.1	1.0	0.4	0.9	0.6	0.5	0.4	1.2	1.9	-0.0	1.3
Medication: Metformin	0.3	0.5	1.9	-0.9	0.1	0.3	-0.0	0.3	-0.4	1.2	-0.6	-0.7	-0.2	-0.5	-1.4
Diabetes (father)	2.7	3.4	9.2	2.7	1.7	1.5	1.8	0.5	2.2	0.2	0.9	3.0	1.2	2.3	1.7
Diabetes (mother)	0.2	0.2	1.3	0.3	0.0	0.3	-0.4	1.1	0.3	-0.4	0.4	0.3	-0.7	-0.3	-0.1
Severe depression (siblings)	0.5	0.6	1.8	-0.6	-1.0	-0.3	-0.8	0.3	0.2	-0.1	0.5	0.9	0.8	1.3	0.9
Pack years adult smoking proportion	0.2	0.2	1.0	0.0	1.0	0.2	0.3	-0.9	0.4	0.4	0.1	0.5	0.1	-0.1	0.5
Impedance of leg (right)	0.6	3.0	8.0	-1.1	-1.7	-0.3	1.1	2.8	0.2	-1.2	-1.8	1.7	2.7	2.7	1.0
Leg fat-free mass (left)	0.1	0.7	1.7	-0.8	-0.2	1.0	0.2	-1.0	-0.5	0.9	1.1	-0.9	-0.3	-0.7	-1.3
Trunk fat percentage	0.3	1.2	4.7	-0.7	-0.7	1.8	-0.3	0.8	-0.8	1.2	0.5	0.3	2.2	-0.9	1.1
Hand grip strength (right)	0.3	0.9	3.2	0.3	-0.6	1.2	1.6	0.2	0.6	0.3	0.7	1.0	1.1	1.8	0.1
Townsend deprivation index at recruitment	2.9	4.1	13.4	-0.9	1.1	-2.6	-3.7	-2.2	-0.8	-2.2	-1.3	-1.8	-2.6	-1.7	-1.3
Current tobacco smoking	1.1	1.7	6.5	0.4	-1.0	1.2	2.5	2.0	-0.7	1.5	0.5	0.2	0.8	-0.5	1.9
Average weekly fortified wine intake	1.1	1.3	4.4	-1.6	-1.7	0.1	-0.5	2.1	-1.0	1.2	-0.5	-1.3	0.7	-1.0	-0.4
Maternal smoking around birth	0.4	0.5	3.7	0.5	0.7	-0.1	-0.7	-0.3	0.2	0.7	0.5	-0.2	-0.4	-1.9	0.7
Fed-up feelings	0.5	1.0	3.5	-0.4	1.0	-0.7	-0.6	-1.4	-0.5	-1.3	-0.2	-1.3	-0.7	-1.9	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.4	-0.4	0.1	0.2	-0.5	0.3	-0.1	-0.2	-0.6	-0.6	-0.7	-0.6	-0.0
Relative age voice broke	1.4	2.1	7.5	-2.0	-1.9	0.8	0.9	0.4	-2.7	0.6	-1.8	-1.4	0.2	0.1	-1.8
Taking other prescription medications	0.4	0.7	2.0	-1.2	-0.2	-0.2	-1.4	0.1	-0.7	0.8	0.9	-1.1	0.5	0.2	-0.9
Age when periods started (menarche)	3.6	8.8	34.8	0.9	-0.8	3.3	3.6	4.2	0.6	2.9	2.1	2.6	5.9	2.2	1.7
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.3	0.6	1.0	0.8	0.6	1.3	1.5	1.0	1.5	0.9	0.2	0.7	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.2	-1.2	-0.8	-1.1	-1.2	-0.9	-1.4	-0.8	0.8	-1.8	-0.8	-0.5	-0.9
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	3.4	1.3	1.4	1.5	1.9	0.6	0.4	0.5	1.0	1.0	0.3	-0.2	0.7
Qualifications: CSEs or equivalent	0.5	0.7	4.5	-0.3	-0.0	-0.6	-0.2	-1.1	0.1	-0.8	0.0	-0.3	-2.1	-0.3	-1.2
Serious illness, injury or assault to yourself	0.1	0.1	0.7	-0.3	-0.4	-0.0	-0.2	-0.4	-0.5	0.0	0.3	-0.1	0.4	0.2	0.9
High blood pressure	0.4	1.0	2.6	1.0	1.4	1.6	1.3	1.0	0.7	1.2	-0.5	0.1	0.4	-0.9	-1.1
Hayfever, allergic rhinitis or eczema	1.1	2.5	8.2	-0.1	1.0	-2.3	-2.9	-2.6	1.0	-2.3	0.3	-0.2	-1.2	-0.9	-0.2
Multivitamins +/- minerals	0.9	1.1	4.7	1.8	1.5	0.0	0.2	0.4	0.6	-1.0	-0.6	0.4	0.5	-1.1	2.2
Stomach or abdominal pain in last month	0.1	0.2	0.7	-0.3	0.3	0.5	-0.8	0.2	-0.2	-0.5	-0.6	0.1	0.4	0.0	-0.2
Supplements: Glucosamine	0.9	1.2	3.0	1.7	1.0	1.0	1.1	0.8	0.5	1.3	0.8	0.6	0.9	1.2	1.5
Diverticular disease/diverticulitis (self-reported)	3.0	3.5	9.2	2.7	1.2	1.1	1.8	-1.4	2.3	-0.4	1.5	2.6	1.1	1.4	3.0
Medication: Atenolol	0.6	0.7	3.0	-0.7	-0.7	-0.5	0.4	1.0	-0.3	-0.0	-0.8	-0.5	-1.7	-0.0	-1.5
Medication: Levothyroxine sodium	0.4	0.7	2.8	-0.0	0.4	0.4	0.0	1.0	0.4	1.4	0.7	-0.4	-1.1	0.8	-1.7
Sitting height	0.2	1.3	4.2	-0.7	0.1	-1.2	-1.7	-0.6	1.1	-1.4	-0.8	-0.1	-0.6	1.5	-2.1
Chronic bronchitis/emphysema (father)	0.3	0.4	1.9	-0.1	-0.2	0.8	0.6	0.7	-0.9	1.4	-0.5	0.3	-0.2	-0.4	-0.4
High blood pressure (mother)	0.5	0.7	3.8	0.7	0.6	0.6	1.1	-0.8	0.3	-0.3	-0.1	0.3	-2.0	1.0	-0.7
Body mass index (BMI)	0.3	1.4	4.0	0.0	0.1	1.9	-0.5	-0.5	-0.6	2.0	1.6	-0.3	0.7	-2.0	0.8
Impedance of leg (left)	0.6	2.9	9.3	-1.0	-1.6	0.2	0.9	3.0	0.1	-0.7	-1.6	1.6	3.0	2.1	1.2
Leg predicted mass (left)	0.1	0.7	1.6	-0.7	-0.3	1.0	0.2	-1.0	-0.5	0.9	1.1	-0.9	-0.4	-0.7	-1.3
Trunk fat mass	0.3	1.1	3.5	-1.0	-0.8	1.9	-0.2	0.7	-0.9	1.5	0.7	0.0	1.9	-0.8	0.4
Waist circumference	0.4	1.5	4.9	0.1	0.5	2.2	0.3	0.6	-0.2	2.0	1.8	0.3	1.7	-1.1	0.7
Number of incorrect matches in round	1.5	2.5	7.4	-0.1	1.1	-1.0	-1.1	-1.2	-1.5	-2.0	-2.5	-1.6	-2.7	-0.6	-1.4
Past tobacco smoking	1.3	2.3	8.1	2.5	1.6	1.2	1.7	-0.1	2.8	-0.2	1.0	2.0	0.9	0.3	0.7
Alcohol usually taken with meals	1.1	1.8	5.7	1.6	0.7	1.5	1.6	2.4	0.6	1.1	-0.1	1.4	0.5	1.8	0.6
Nervous feelings	0.2	0.3	3.1	0.3	0.1	-0.0	-0.2	0.2	-0.2	-0.6	-1.8	0.4	-0.1	-0.1	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	-0.5	-0.3	-0.3	0.6	-0.8	-0.5	0.5	-0.4	-0.6	-0.6	-0.8	0.1
Hearing difficulty/problems with background noise	2.0	3.2	8.6	-2.7	-1.6	-1.4	-2.9	-0.3	-1.4	-0.7	0.9	-2.6	-1.0	-2.2	-1.6
Hair/balding pattern: Pattern 2	1.4	1.8	5.5	-1.3	-2.4	0.5	0.5	2.0	-2.2	1.9	-0.8	-0.9	0.6	0.4	-0.1
Had menopause	0.7	0.9	4.8	-0.0	-0.4	-0.0	-0.8	-0.5	-0.5	0.3	-0.6	-0.7	1.0	-2.2	1.5
Had other major operations	1.1	1.4	5.9	0.6	1.6	-1.4	-2.4	-0.7	1.5	-0.6	1.1	0.5	0.1	0.7	0.8
Forced vital capacity (FVC)	0.2	0.8	4.0	0.2	0.7	-0.2	-0.3	-0.2	1.4	-0.3	-1.4	0.3	-0.9	0.5	-2.0
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.7	-1.6	-1.2	-1.2	-1.2	-1.0	-1.6	-1.3	0.1	-1.5	-0.4	-0.8	-0.8
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.8	0.3	-0.5	0.3	0.9	0.1	-0.7	0.3	-0.1	0.1	0.0	0.2	0.7
Qualifications: None of the above	0.8	1.7	4.0	2.0	1.8	0.6	-0.8	0.2	1.0	0.3	1.9	1.7	1.3	-0.8	1.7
Financial difficulties in last 2 years	1.9	2.5	8.4	1.3	2.3	-1.0	-2.9	-1.7	1.9	-1.9	0.8	1.0	-0.4	-0.9	1.0
Mouth/teeth dental problems	0.9	1.3	4.9	-1.3	-0.8	-0.6	-0.5	-0.5	-0.8	-1.4	-1.8	-0.7	-1.1	-0.3	-2.2
Heart attack	0.2	0.3	1.4	0.0	0.7	-0.3	-0.3	-0.1	0.4	-0.1	1.2	-0.0	-0.6	-0.1	-0.9
Allergy	0.8	1.7	5.9	0.7	-0.4	2.0	2.4	2.0	-0.5	2.1	-1.1	0.2	0.3	-0.1	-0.1
Pain all over the body in last month	0.6	0.6	3.8	-0.2	-0.6	0.3	-0.6	2.0	0.6	-0.5	0.7	0.7	0.6	0.0	0.7
Diabetes (self-reported)	0.5	0.7	1.6	-1.1	0.7	-0.3	-0.8	0.5	-0.8	0.4	-1.1	-1.2	-0.3	-1.1	-1.2
Hayfever/allergic rhinitis (self-reported)	2.1	2.8	11.0	0.0	0.8	-2.8	-3.3	-2.0	0.8	-2.0	0.2	-1.2	-1.7	-1.0	-0.6
Medication: Ramipril	0.6	0.8	3.4	-0.4	0.3	0.8	-1.2	1.2	0.2	-0.5	-1.2	0.3	-0.2	-0.5	-1.9
Medication: Simvastatin	0.5	0.7	5.5	-0.2	0.9	0.6	0.1	0.7	0.2	0.3	-0.8	0.3	-0.8	0.1	-2.4
Fluid intelligence score	2.9	6.1	17.8	-4.2	-3.9	-2.1	-1.0	0.4	-3.1	0.8	-1.2	-3.5	-2.5	0.4	-2.2
Illnesses of siblings	0.7	1.0	5.9	0.5	-1.0	1.2	1.0	0.7	0.0	0.7	-0.4	1.1	0.5	2.4	0.5
Neuroticism score	0.5	1.1	3.1	1.2	1.7	0.2	-0.6	-1.6	0.2	-1.2	-0.8	0.4	0.3	-1.8	0.3
Weight	0.2	1.2	3.4	-1.3	-0.9	1.8	0.2	0.3	-1.0	1.8	0.9	-0.7	0.9	-1.0	-0.6
Impedance of arm (right)	0.3	1.4	6.6	0.0	0.5	-1.3	-0.8	0.8	0.4	-2.0	-2.6	1.2	1.0	0.9	0.1
Arm fat percentage (right)	0.3	1.1	3.1	0.3	0.2	1.8	-0.8	-0.0	-0.1	1.5	1.1	0.6	1.5	-1.3	1.2
Trunk fat-free mass	0.2	1.3	5.1	-1.5	-1.1	0.9	1.1	0.2	-1.0	1.1	0.8	-1.3	-0.2	-0.0	-2.2
Hip circumference	0.3	1.5	4.7	-1.1	-0.2	1.5	-0.5	-0.2	-1.2	1.5	0.5	-1.1	1.9	-2.2	0.4
Time employed in main current job	0.2	0.2	0.5	-0.5	-0.5	-0.3	0.3	0.2	-0.7	-0.3	-0.7	-0.5	0.4	0.6	-0.1
Alcohol intake versus 10 years previously	0.3	0.5	1.9	0.2	0.5	0.2	-0.1	-1.4	0.8	0.4	0.7	-0.6	-0.5	-1.2	0.0
Father’s age at death	0.3	0.3	2.5	-0.3	0.5	-1.6	-0.8	0.5	0.3	-0.1	0.5	-0.3	-0.1	0.1	-0.3
Worrier / anxious feelings	0.2	0.4	1.1	0.4	0.8	0.6	0.6	-0.5	-0.0	-0.0	-0.4	0.7	1.0	-0.7	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.8	0.6	0.7	1.0	-0.0	0.1	0.1	0.2	-1.2	0.4	0.8	-0.1	1.3
Falls in the last year	1.2	1.6	3.3	1.7	1.5	-0.1	-1.8	-0.9	1.6	-1.0	1.4	1.1	0.7	-0.7	1.4
Hair/balding pattern: Pattern 3	0.2	0.2	0.9	0.6	0.2	0.0	0.8	-0.2	-0.2	-0.2	0.0	-0.4	-0.6	0.9	-0.5
Number of live births	0.8	1.1	2.4	1.1	0.3	1.0	-0.8	1.0	0.7	1.3	1.2	0.4	1.1	-1.5	1.2
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	4.2	0.5	0.7	-0.6	-0.8	-0.6	1.9	-1.2	-1.5	0.4	-1.5	0.4	-2.1
Pulse rate	0.6	1.0	2.7	0.5	0.9	-1.0	-1.5	-1.6	1.2	-1.3	0.6	0.2	-0.6	-0.6	0.2
Happiness	0.9	1.1	2.9	0.9	1.7	-0.1	-0.9	-1.1	0.9	-1.2	-0.0	0.5	-0.8	-1.7	-1.1
Noisy workplace	1.4	1.7	5.3	1.9	1.9	1.2	0.4	-1.1	1.1	-0.7	-0.3	1.2	0.4	-2.3	1.1
Qualifications: A levels/AS levels or equivalent	0.2	0.4	3.5	0.0	-0.3	-0.3	-0.1	0.4	0.4	0.1	0.5	0.4	0.0	1.9	-0.2
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	3.9	-0.7	1.3	-1.3	-1.4	-1.7	-0.1	-0.9	-1.0	-1.0	-2.0	-1.8	-1.3
Mouth/teeth dental problems: Dentures	1.4	2.4	7.8	1.0	0.3	1.4	-0.0	0.6	0.1	2.8	2.6	1.0	2.2	-0.6	2.2
Asthma	0.7	1.3	4.1	-1.7	-1.1	-1.2	-1.5	0.3	-0.7	-0.6	1.7	-0.5	-0.2	2.0	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.3	0.2	0.5	-0.7	-0.4	-0.4	0.7	-1.1	-0.1	-0.2	0.3	-0.0	1.1
Medication: Cholesterol lowering	0.8	1.2	4.3	-0.3	0.9	-0.5	-2.1	-0.1	-0.0	-1.5	-0.1	-0.2	-1.5	-0.8	-1.9
Depression (self-reported)	1.0	1.1	6.7	0.9	-0.3	0.1	0.7	-1.1	0.4	0.3	2.6	0.7	0.7	0.2	1.8
Medication: Lansoprazole	2.0	2.3	6.1	1.9	-0.1	2.0	0.5	1.2	1.9	0.8	1.9	2.5	1.5	1.2	0.8
Prospective memory result	0.8	1.0	3.4	0.9	1.3	-0.0	0.8	-0.0	0.8	-1.0	1.8	1.1	1.6	-0.4	0.7
Lung cancer (father)	0.7	0.8	3.6	-0.6	0.0	1.0	1.1	0.6	-1.9	0.9	-0.7	-1.0	-0.0	-0.3	-0.6
Illnesses of mother	0.3	0.4	1.9	0.0	-0.0	0.1	-0.5	1.0	0.6	-0.6	0.8	0.1	1.4	0.2	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	5.6	1.5	1.4	-0.4	-0.4	-1.3	2.4	-1.8	-2.3	0.7	-1.9	0.3	-1.4
Pulse wave Arterial Stiffness index	0.5	0.6	1.3	-0.7	-0.6	-0.7	0.0	-0.1	0.8	0.9	0.3	-1.1	-1.1	-0.7	-1.1
Impedance of arm (left)	0.3	1.3	4.6	-0.5	-0.3	-1.7	-0.2	1.0	0.3	-2.1	-1.9	0.9	0.5	1.5	0.3
Arm fat mass (right)	0.2	0.9	3.0	-0.3	-0.1	1.7	-0.4	-0.1	-0.4	1.5	1.1	0.1	1.2	-1.3	0.5
Trunk predicted mass	0.2	1.3	4.8	-1.5	-1.1	1.0	1.1	0.3	-1.0	1.2	0.9	-1.2	-0.1	0.1	-2.2
Standing height	0.3	2.9	10.0	-2.8	-2.1	0.1	1.8	1.4	-0.8	-0.1	-1.4	-0.8	0.5	1.9	-3.2
Length of working week for main job	0.5	0.6	1.8	-1.1	-0.6	-0.3	-1.1	-0.5	-0.7	-0.1	1.4	-0.5	-0.3	0.4	-1.0
Exposure to tobacco smoke at home	0.5	0.6	1.8	-0.1	0.7	-0.6	-0.4	-1.3	-0.8	-0.6	-0.7	-0.5	-0.2	-1.3	0.8
Breastfed as a baby	1.9	2.4	7.5	1.6	0.3	2.7	1.5	2.3	0.4	1.6	-0.2	1.7	0.9	1.5	1.5
Tense / ‘highly strung’	0.3	0.6	2.1	0.2	1.5	0.0	0.2	0.5	-0.3	-1.3	-0.7	0.1	0.3	-1.2	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	4.7	0.2	-1.0	-0.1	0.2	0.9	-0.3	0.4	1.0	1.0	1.2	1.1	2.2
Hair/balding pattern: Pattern 4	0.2	0.5	1.8	0.7	-0.9	0.5	0.8	0.4	0.1	0.5	0.6	0.9	-0.1	1.3	0.8
Birth weight of first child	0.6	1.1	3.4	0.9	-0.3	1.5	1.7	-1.0	0.9	0.4	-1.8	0.8	-0.4	0.1	0.9
Peak expiratory flow (PEF)	1.2	2.7	6.2	-1.3	-0.4	-2.4	-1.8	-0.3	0.3	-1.9	-0.9	-1.7	-2.5	-1.3	-2.4
Pulse wave reflection index	1.0	1.3	4.2	-1.6	-1.6	-1.9	-0.8	-0.2	-0.6	-0.5	-0.0	-2.0	-1.0	-0.6	0.2
Ever highly irritable/argumentative for 2 days	0.2	0.3	1.2	-0.2	-0.0	0.8	0.3	-0.1	-0.9	0.1	-0.6	0.2	-0.3	0.0	-1.1
Loud music exposure frequency	0.9	1.0	3.2	1.8	1.3	0.5	0.2	-0.8	1.2	-0.9	-0.0	1.6	0.1	-0.9	0.9
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.8	-0.2	0.0	-1.3	-0.6	-0.7	0.4	-1.3	-1.3	-0.3	-1.2	1.4	-0.3
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.8	-1.0	-0.7	-0.7	-0.6	-0.9	-0.9	-0.4	-0.9	-1.5	-2.0	0.3	-0.3
Blood clot in the leg (DVT)	0.8	1.1	2.4	0.7	1.5	-0.2	-1.0	-0.9	0.8	-1.3	1.5	0.8	1.0	-0.6	1.2
Medication: Paracetamol	1.0	1.6	9.5	0.3	-0.1	0.4	-0.2	1.4	0.0	1.1	0.2	0.5	3.1	0.2	2.5
Headache pain in last month	1.5	2.6	6.8	-2.5	-1.3	-1.6	-1.2	-1.4	-1.5	-1.1	-1.5	-2.6	-1.2	-1.3	-1.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	2.3	-0.8	-1.4	-0.7	0.1	-0.2	-0.7	-0.3	0.5	-0.5	0.9	0.1	1.5
Glaucoma (self-reported)	1.2	1.4	5.7	-1.2	-1.0	0.7	1.7	2.4	-1.2	1.1	-0.2	-0.4	0.2	1.4	-0.8
Gout (self-reported)	0.2	0.2	1.1	-0.1	0.0	-0.4	0.3	-0.9	0.1	-0.3	-0.2	-0.4	0.1	0.0	1.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	3.6	-0.8	0.0	-0.4	-1.2	-0.1	-0.1	-0.1	0.0	-1.2	-1.6	0.3	-1.9
Medication: Amlodipine	0.4	0.5	2.0	-0.3	0.2	-0.4	-0.3	-0.8	-0.7	-0.0	-1.3	-0.6	-0.9	0.2	-1.4
Medication: Ventolin 100micrograms inhaler	1.0	1.3	4.4	-0.4	-1.2	-0.9	-0.2	1.9	-0.1	0.1	1.9	0.3	0.5	2.1	1.2
Birth weight	0.6	1.3	3.8	1.5	1.6	0.7	2.0	-0.9	0.7	-1.7	-1.1	0.9	-0.2	0.1	0.7
Chronic bronchitis/emphysema (mother)	0.5	0.6	3.1	-0.3	-0.7	0.4	0.1	-0.5	-0.7	0.9	-0.6	-0.1	1.8	-0.2	1.2
High blood pressure (siblings)	1.0	1.4	5.2	1.0	1.6	-1.1	-1.4	-0.6	1.2	-1.5	0.8	-0.2	-0.4	-2.3	0.4
Forced vital capacity (FVC), Best measure	0.5	1.8	6.2	1.9	1.6	0.5	0.4	-0.7	2.5	-1.1	-1.9	1.6	-0.7	0.6	-0.5
Body fat percentage	0.4	1.5	5.2	-0.4	-0.6	2.2	-0.4	0.9	-0.6	1.7	0.8	0.6	2.3	-0.8	1.3
Leg fat percentage (right)	0.5	1.7	6.1	-0.5	-0.6	2.3	-0.1	0.9	-0.5	1.9	1.0	0.6	2.5	-0.8	1.5
Arm fat-free mass (right)	0.2	1.2	2.8	-1.7	-1.3	1.2	0.7	-0.0	-0.8	1.3	1.4	-1.2	0.3	-0.2	-1.4
Exposure to tobacco smoke outside home	1.4	1.9	6.0	0.3	1.4	-1.6	-2.4	-1.6	0.1	-0.8	-0.8	-1.4	-1.5	-2.0	0.3
Comparative body size at age 10	0.5	1.4	4.6	0.1	0.9	-1.3	-1.4	-2.1	-0.3	-0.7	0.6	-1.1	-0.9	-2.1	0.2
Number of full brothers	0.4	0.6	1.8	-0.4	-1.2	-0.5	-0.4	0.4	-0.8	0.9	0.4	-0.8	0.1	-0.7	1.4
Worry too long after embarrassment	0.2	0.3	1.0	0.9	0.7	0.7	0.4	0.5	0.4	-0.1	-1.0	0.3	0.3	-0.5	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.9	0.4	-0.0	0.9	-0.0	-0.3	-0.6	0.8	1.3	0.9	1.7	-0.2	0.9
Wheeze or whistling in the chest in last year	0.3	0.6	2.1	-0.6	0.1	-0.8	-0.8	0.2	-0.3	-0.1	1.5	-0.6	1.0	0.1	1.2
Number of children fathered	0.3	0.3	1.5	-0.6	-0.0	-0.2	0.5	-1.2	-0.2	-0.1	-0.8	-0.8	-0.7	0.0	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.6	-1.2	-1.0	0.0	0.7	0.4	-1.6	0.3	-0.7	-0.9	-0.7	-0.1	-1.4
Age at first live birth	0.7	1.3	3.5	-1.2	-1.5	-1.2	-0.8	0.9	-0.1	-1.0	-1.3	-0.5	-1.1	1.2	-1.9
Pulse wave peak to peak time	0.5	0.5	1.2	0.7	0.5	0.7	0.1	0.1	-0.8	-0.9	-0.5	1.1	1.0	0.9	0.8
Health satisfaction	0.4	0.5	2.3	-1.5	-1.0	0.4	-0.1	0.0	-1.0	0.3	0.6	-0.7	0.4	-0.3	-0.4
Shortness of breath walking on level ground	0.6	0.7	3.1	-0.1	0.8	-0.4	-0.4	-0.4	0.4	-1.1	1.8	0.4	1.1	-0.6	-1.2
Qualifications: College or University degree	0.2	0.6	1.9	0.0	-1.0	0.5	0.1	0.3	0.5	0.9	-0.9	0.2	-0.9	1.4	-1.2
Eye problems/disorders: None of the above	0.8	0.9	2.9	0.3	-0.7	-0.3	-1.7	-1.2	-0.2	-1.7	-1.2	0.4	-0.2	0.8	0.5
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.2	-1.2	-1.3	-1.2	-1.3	0.3	-0.9	-0.1	-1.4	-1.5	-1.2	0.1	-0.5
Emphysema/chronic bronchitis	2.8	3.1	10.4	1.4	-0.1	2.5	1.7	1.6	-0.3	1.8	1.3	1.8	3.2	0.8	2.1
Medication for pain relief, constipation, heartburn	0.2	0.4	3.1	0.5	0.1	0.4	0.2	0.1	0.1	-0.4	-0.0	0.2	-1.8	0.6	-0.9
Neck or shoulder pain in last month	0.2	0.3	1.1	-0.0	0.5	0.0	-0.6	0.6	-0.5	-0.5	1.0	-0.2	0.3	-0.8	0.0
Medication: Blood pressure	0.5	0.8	2.3	0.5	0.7	1.4	0.7	0.5	0.1	1.5	-1.4	0.2	-0.4	-0.1	-1.5
Angina (self-reported)	0.4	0.5	2.4	0.1	1.1	0.2	0.4	0.3	0.5	-0.7	-0.2	0.5	-0.9	-0.5	-1.5
Migraine (self-reported)	0.9	1.2	4.2	-0.1	-1.1	2.1	1.5	0.3	0.1	1.7	-1.2	0.9	0.6	-0.3	-0.6
Medication: Ibuprofen	0.3	0.4	0.8	-0.3	0.3	-0.9	-0.6	-0.1	0.7	-0.9	0.8	-0.1	0.5	0.4	0.7
Medication: Allopurinol	0.2	0.2	0.8	-0.4	0.2	-0.4	-0.3	-0.9	0.0	-0.7	-0.3	-0.4	0.1	-0.9	0.1
Medication: Omeprazole	1.2	1.4	5.2	-0.2	-1.4	1.6	1.7	0.8	-1.2	2.3	-0.3	-0.0	0.7	1.3	-0.3
Medication: Seretide 50 evohaler	0.7	0.8	4.9	0.4	-0.3	0.1	0.3	1.1	0.4	1.0	0.6	1.0	0.0	2.2	0.7
Mean time to correctly identify matches	0.8	1.5	6.1	2.1	1.3	1.2	-1.1	0.4	0.2	0.4	0.8	0.9	1.3	-0.4	2.5
Heart disease (mother)	0.7	0.9	2.1	-0.6	0.6	-0.7	-0.6	-1.4	-1.0	-0.2	-1.4	-1.1	-0.7	-1.3	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	6.2	-1.9	-1.6	0.1	-0.2	1.6	-2.5	0.5	-0.7	-1.5	-0.7	0.6	-1.1
Whole body fat mass	0.3	1.3	4.9	-0.7	-0.6	2.2	-0.0	0.5	-0.7	1.9	1.0	0.2	1.9	-0.8	0.6
Leg fat mass (right)	0.4	1.7	6.6	-0.5	-0.8	2.6	0.3	0.6	-0.5	2.2	1.2	0.4	2.0	-0.6	0.9
Arm predicted mass (right)	0.3	1.4	4.0	-2.0	-1.6	1.1	0.7	0.1	-1.1	1.4	1.2	-1.4	0.2	-0.1	-1.6
Pulse rate, automated reading	0.2	0.6	2.4	-1.2	0.0	-0.3	-0.8	-0.6	0.1	0.1	-0.1	-0.9	-0.6	-1.2	-1.5
Alcohol intake frequency.	1.2	2.7	9.0	-1.9	0.1	-0.9	-1.7	0.3	-1.3	0.5	-1.1	-2.5	-2.0	-3.0	-1.6
Comparative height size at age 10	0.1	0.8	4.1	-0.1	-0.0	-0.6	0.4	0.1	-0.0	-1.5	-2.0	-0.7	-1.2	0.8	-0.2
Number of full sisters	1.0	1.3	4.0	0.1	0.8	-2.0	-1.5	-1.7	-0.6	-1.8	0.4	-0.3	-0.3	-1.0	0.5
Suffer from ‘nerves’	0.1	0.2	0.6	0.5	0.3	-0.4	-0.7	-0.3	-0.5	-0.1	-0.2	-0.4	0.6	0.0	0.4
Overall health rating	0.5	1.0	4.8	0.0	1.3	-0.4	-2.2	-0.5	0.7	-0.6	0.2	-0.1	1.4	-1.4	0.8
Chest pain or discomfort	0.2	0.2	1.1	-0.1	0.2	-0.3	-0.4	-0.7	0.3	0.0	1.1	-0.0	0.5	-0.7	-0.0
Had major operations	0.6	0.7	2.4	-0.1	1.3	-0.9	-0.4	-0.5	0.1	0.7	-0.3	-1.0	-1.0	-1.5	-0.0
Age at last live birth	0.8	1.1	2.8	-0.9	-1.7	-1.3	-1.0	0.4	-0.3	-0.6	-1.3	-1.0	-1.5	1.1	-0.6
Family relationship satisfaction	0.3	0.4	1.3	0.9	0.5	0.7	1.1	-0.1	0.8	0.3	-0.1	0.9	-0.7	-0.2	0.0
Leg pain on walking	0.7	0.9	3.7	0.7	1.2	0.4	0.6	-0.2	-0.0	0.1	1.7	0.0	1.2	-1.9	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.7	-1.4	-0.6	0.0	-0.7	-0.4	-1.7	0.2	-1.0	-1.5	-0.0	-0.9	-0.4
Commuting to job workplace: Car/motor vehicle	1.2	1.4	6.2	1.0	-0.7	1.2	0.5	1.1	0.8	0.9	0.9	0.9	1.5	0.8	2.5
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	5.3	0.3	-0.9	1.8	2.3	0.9	-0.5	1.9	0.2	0.2	0.5	0.0	0.1
Medication: Aspirin	0.8	1.0	3.1	0.0	-0.8	1.5	1.0	1.3	0.0	1.8	0.8	0.8	1.1	0.5	-0.6
Supplements: Vitamin C	0.6	0.8	3.7	0.9	-0.3	-0.5	-0.4	-0.4	1.1	-1.2	0.4	0.3	-1.9	1.0	0.1
Knee pain experienced in last month	0.9	1.4	4.1	2.0	1.8	1.0	0.8	-0.9	0.8	1.2	1.2	0.7	0.8	-1.2	0.7
Hypertension (Self-reported)	0.6	1.5	3.6	1.3	1.9	1.8	1.6	0.9	1.0	1.1	-0.4	0.6	0.1	-1.1	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.7	5.4	1.9	-0.6	0.9	1.1	0.4	1.1	1.4	0.8	1.4	1.4	1.1	2.3
Illnesses of father: Heart disease	0.6	0.8	3.5	0.7	0.4	0.6	0.4	-1.2	1.0	-0.5	0.1	1.4	-0.3	1.9	0.6
Illnesses of siblings: Diabetes	0.7	0.8	2.2	0.0	1.1	0.2	-0.4	0.9	0.0	0.8	-1.5	-0.7	-1.3	-1.4	-0.7
Smoking status: Previous	1.4	2.1	5.3	-2.1	-1.5	-1.5	-2.3	-0.8	-2.2	0.0	-1.1	-1.7	-0.7	0.3	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.9	1.1	-0.1	0.1	0.9	0.5	2.0	-0.2	0.8	1.4	0.7	1.7	0.1
Whole body fat-free mass	0.2	1.0	3.4	-1.3	-0.8	1.0	0.6	-0.3	-0.9	1.1	1.0	-1.2	-0.1	-0.4	-1.8
Leg fat-free mass (right)	0.2	0.8	1.6	-0.7	-0.1	1.0	-0.0	-1.1	-0.6	1.1	1.2	-1.1	-0.4	-1.1	-1.3
Arm fat percentage (left)	0.2	0.9	2.4	-0.1	-0.1	1.6	-0.7	-0.1	-0.2	1.4	1.3	0.4	1.3	-1.1	1.2
Average weekly red wine intake	2.1	3.0	9.9	1.3	0.5	2.5	2.1	3.1	0.4	2.7	1.0	1.2	2.0	0.2	0.3
Handedness (chirality/laterality): Left-handed	0.9	1.1	3.4	1.8	1.6	-0.2	-0.4	-1.5	1.5	-0.9	0.3	1.3	-0.2	0.4	0.2
Mood swings	0.9	1.7	4.3	2.1	1.8	1.9	1.3	0.2	1.0	-0.4	0.0	1.8	0.7	0.2	1.7
Loneliness, isolation	0.4	0.6	3.3	0.2	1.0	0.4	0.5	-0.8	0.1	-0.5	-0.7	-0.5	-0.4	-1.8	0.2
Long-standing illness, disability or infirmity	0.3	0.5	1.7	0.2	1.3	0.7	-0.2	0.7	-0.8	1.1	0.5	-0.7	0.4	-0.6	-0.3
Ever had bowel cancer screening	0.3	0.4	1.4	1.2	0.5	0.1	0.2	-0.2	0.8	0.4	0.7	0.8	-0.0	0.6	1.0
Diabetes diagnosed by doctor	0.9	1.5	4.0	-1.4	0.7	-0.6	-0.9	0.2	-1.1	0.2	-1.9	-1.7	-0.5	-2.0	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	4.9	5.3	12.3	-2.8	-0.9	-3.2	-2.0	-2.1	-1.6	-2.3	-2.2	-2.7	-3.5	0.0	-2.0
Friendships satisfaction	0.8	1.0	3.5	-0.9	-1.4	0.7	0.9	0.4	-0.2	1.6	-0.3	-0.7	-1.0	0.5	-1.9
Qualifications: nursing, teaching	0.7	1.1	4.7	-1.1	-1.7	-0.9	0.0	0.0	-0.7	0.3	-0.3	-1.2	-1.1	2.2	-1.0
Commuting to job workplace: Walk	2.3	2.4	6.2	-2.5	-0.3	-1.8	0.0	-1.7	-1.7	-0.4	0.1	-2.5	-1.3	-0.6	-2.4
Eye problems/disorders: Cataract	3.5	4.1	6.2	2.5	2.0	1.9	2.5	2.1	2.2	2.0	2.0	2.1	2.3	-0.2	1.5
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.4	0.1	-0.3	-0.6	0.2	0.7	0.7	-0.0	-0.3	-0.1	-0.1	-0.2	0.2
Medication for cholesterol	1.4	2.2	9.1	-0.5	-0.4	-2.2	-1.7	-3.0	0.1	-1.1	1.0	-1.1	-1.6	-1.4	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	3.9	0.7	1.5	0.8	1.0	-2.0	1.3	-0.2	-0.1	0.9	0.4	-1.0	-0.4
Back pain experienced in last month	0.9	1.3	3.4	-1.0	1.3	-1.2	-1.8	-1.4	-0.8	-0.1	0.1	-1.8	-0.5	-1.1	-0.8
Mineral and other dietary supplements	0.4	0.5	3.0	-1.1	-0.2	-0.5	-0.7	-0.1	-0.3	-0.8	-0.3	0.1	-0.6	0.4	-1.7
Breast cancer (self-reported)	1.6	1.9	7.6	-0.8	0.6	-2.1	-2.8	0.0	-0.3	-1.7	-1.2	-1.2	-1.4	-0.5	-1.2
Asthma (self-reported)	0.7	1.5	3.7	-1.9	-1.2	-1.5	-1.8	0.1	-0.7	-0.6	1.6	-0.6	0.1	1.9	0.4
Osteoporosis (self-reported)	0.1	0.2	0.5	-0.3	-0.3	0.6	0.4	0.7	0.0	0.3	-0.6	0.0	0.1	-0.7	0.1
Osteoarthritis (self-reported)	0.6	0.7	3.2	1.3	1.8	0.4	0.1	0.4	-0.1	1.1	-1.0	-0.5	-0.0	-0.9	0.6
Medication: Aspirin	0.6	0.8	2.0	-0.0	-0.5	1.1	1.2	1.1	0.3	1.4	0.7	1.0	0.9	0.6	-0.9
Medication: Gliclazide	1.1	1.3	5.2	-1.9	-1.2	0.2	-0.4	-0.0	-2.3	1.0	-1.0	-1.6	0.4	0.4	0.0
Illnesses of father: None of the above (group 1)	1.2	1.4	5.4	-1.3	-0.9	-0.3	0.3	1.5	-1.4	0.8	-0.4	-2.3	-0.2	-1.8	-1.1
Smoking status: Current	0.9	1.5	5.6	0.0	-1.2	0.9	2.4	2.2	-0.8	1.5	0.4	-0.2	0.1	-0.6	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	6.5	1.6	1.6	-1.1	-0.4	0.1	2.5	-0.8	-0.5	0.3	-2.1	-0.1	-0.6
Whole body water mass	0.2	1.0	3.5	-1.3	-0.8	1.0	0.5	-0.3	-0.8	1.1	1.2	-1.2	-0.1	-0.2	-1.9
Leg predicted mass (right)	0.1	0.8	1.6	-0.7	-0.1	1.0	-0.0	-1.1	-0.5	1.1	1.1	-1.1	-0.4	-1.0	-1.3
Arm fat mass (left)	0.2	0.8	2.5	-0.7	-0.3	1.6	-0.4	-0.1	-0.5	1.5	1.1	-0.2	1.0	-1.4	0.1
Number of self-reported non-cancer illnesses	0.3	0.6	2.5	-0.5	0.4	-0.4	-0.8	-0.6	-0.8	0.4	-0.7	-1.6	-0.8	-0.6	-0.7
Average weekly champagne plus white wine intake	2.7	3.7	14.0	-2.1	-1.3	-1.5	0.1	-0.4	-1.3	-0.9	-1.7	-2.1	-3.7	-0.1	-3.5
Miserableness	0.4	0.8	3.3	0.1	0.6	0.0	-1.2	-0.6	-0.4	-0.4	0.1	-0.0	1.3	-1.3	1.8
Guilty feelings	0.6	1.0	5.7	1.0	0.7	0.1	-0.8	-1.3	-0.1	-0.5	-2.4	0.3	0.3	-1.2	0.3
Wears glasses or contact lenses	0.5	0.6	1.5	-0.4	-0.7	0.0	1.2	-0.3	-1.1	0.5	-0.7	-1.0	-0.8	-0.2	-1.2
Ever taken oral contraceptive pill	0.4	0.5	2.3	0.9	0.6	0.4	0.4	0.1	0.0	0.1	-0.8	0.6	-1.0	1.5	-0.1
Hearing aid user	1.4	1.6	5.8	1.2	1.4	0.7	-0.0	1.3	1.5	-0.2	2.4	1.2	1.5	-1.1	0.2
Mother’s age at death	0.7	0.9	2.9	-1.4	-0.6	-0.8	-0.1	0.9	-0.5	-0.7	-0.9	-0.7	-0.2	1.3	-1.7
Financial situation satisfaction	1.9	2.3	5.3	1.2	1.9	-0.7	-2.3	-2.0	1.7	-2.1	-0.6	0.6	-1.6	-1.5	-0.1
Tinnitus: Yes, now most or all of the time	3.4	4.0	12.9	-1.6	0.1	-2.6	-2.1	-1.8	-0.9	-1.3	-2.0	-2.5	-2.1	-3.6	-0.9
Commuting to job workplace: Public transport	0.7	0.9	3.8	-1.4	-1.5	-1.9	-0.7	-0.8	-0.2	-0.3	0.2	-0.7	-0.6	0.6	-0.6
Eye problems/disorders: Glaucoma	1.8	2.2	7.6	-2.0	-2.0	0.0	1.2	2.8	-2.2	0.5	-0.7	-0.9	0.3	1.5	-0.6
Medication: Blood pressure	0.3	0.5	1.7	0.0	0.5	1.0	1.2	1.3	0.4	0.2	-0.9	0.2	0.2	0.1	-1.1
Pain type(s) experienced in last month: Hip pain	1.2	1.5	5.9	1.4	1.0	1.9	1.2	0.0	0.1	2.4	1.4	0.2	0.7	-0.9	0.9
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.2	0.4	-0.5	0.5	0.4	-0.0	-0.4	0.1	0.1	-0.2	0.7	-1.1	1.0
High cholesterol (Self-reported)	0.5	0.9	5.4	-0.8	1.0	0.1	-0.1	1.7	-0.2	-0.9	0.1	0.5	0.3	0.1	-2.3
Medication: Bendroflumethiazide	0.2	0.4	1.0	-0.3	0.8	-0.7	-0.7	0.5	0.3	-0.3	-0.7	-0.7	-0.4	-0.7	-1.0
Medication: Paracetamol	1.2	1.9	11.6	0.6	0.8	0.0	-0.1	1.1	0.4	1.1	0.8	0.7	3.4	0.1	2.6
Medication: Lisinopril	1.1	1.4	5.3	0.6	-0.1	1.8	1.8	0.8	0.3	2.3	-0.2	0.8	1.7	0.0	0.4
Medication: Atorvastatin	0.8	1.0	4.5	-1.2	-1.6	0.1	0.9	1.5	-2.1	-0.4	-0.1	-0.5	0.0	0.6	0.0
Illnesses of father: High blood pressure	0.4	0.5	1.9	-0.7	-0.0	-0.8	-1.2	0.4	0.1	-0.8	-0.2	-0.2	0.4	1.4	-0.6
Alcohol drinker status: Never	0.3	0.4	1.3	-0.6	0.3	0.5	0.7	1.1	-0.3	0.6	0.4	-0.4	-0.9	-0.9	-0.1
Ever smoked	1.0	1.8	7.1	-2.3	-1.2	-0.9	-1.2	0.3	-2.7	-0.5	-0.6	-1.7	-0.1	-1.0	-0.6
Basal metabolic rate	0.2	1.0	2.3	-1.4	-0.9	1.2	0.5	-0.2	-0.9	1.3	1.1	-1.1	0.2	-0.5	-1.5
Leg fat percentage (left)	0.6	2.2	7.5	-0.4	-0.4	2.6	-0.3	1.1	-0.7	2.1	1.0	0.6	2.7	-1.3	1.6
Arm fat-free mass (left)	0.2	1.2	3.1	-1.6	-0.9	1.3	0.5	0.0	-0.9	1.5	1.1	-1.2	0.4	-0.7	-1.8
Number of operations (self-reported)	1.9	2.8	9.9	-1.1	1.2	-3.2	-2.9	-2.4	0.2	-0.4	-0.1	-1.9	-1.5	-0.8	-0.8
Average weekly beer plus cider intake	0.2	0.3	1.8	0.3	0.7	0.3	-0.3	-0.8	-0.3	-0.1	-0.2	-0.1	0.6	-1.3	-0.1
Irritability	0.1	0.2	1.1	-0.0	0.1	0.7	0.3	-0.1	-1.1	0.3	-1.0	-0.3	0.2	-0.1	-0.1
Risk taking	0.4	0.6	2.6	-1.0	-0.5	-0.6	-0.0	0.0	-1.6	-0.3	-0.0	-0.9	-0.0	1.6	0.2
Ever had prostate specific antigen (PSA) test	1.0	1.2	8.0	0.2	0.3	-0.1	0.5	1.0	0.4	-0.7	1.3	0.6	-0.3	2.8	-1.3
Fractured/broken bones in last 5 years	0.5	0.6	3.4	-1.2	0.1	-0.9	0.1	-1.8	-0.1	-0.6	-0.0	-0.6	-0.2	-1.0	-0.3
Age started oral contraceptive pill	0.6	0.8	2.3	-0.0	0.9	-0.6	-1.5	-0.7	-1.2	-0.3	-1.0	-1.2	-0.0	-1.0	-0.6
Diastolic blood pressure, automated reading	0.4	1.4	5.3	0.5	-0.3	2.3	0.8	-1.0	0.2	1.7	-0.0	0.6	2.2	-0.7	1.0
Ever depressed for a whole week	0.3	0.4	1.3	0.5	-0.0	0.9	0.0	0.5	-0.9	1.2	-1.0	-0.1	-0.6	-0.1	-0.3
Unable to work because of sickness or disability	0.9	1.1	3.1	1.5	0.4	0.5	-0.7	-0.4	0.9	-0.1	1.5	1.3	1.4	0.0	1.8
Commuting to job workplace: Cycle	0.2	0.3	0.9	0.3	0.4	-0.7	-0.9	-0.0	0.3	-0.9	-0.8	0.4	0.1	0.3	0.3
Myopia	1.1	1.7	8.4	0.0	0.5	-1.6	-1.2	-1.2	1.2	-1.0	-1.0	-0.7	-2.9	0.0	-1.4
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.2	-1.1	-1.5	-1.5	-1.3	-1.4	-0.8	-0.9	0.1	-0.3	-0.3	0.4	1.1
Cholesterol lowering medication	0.9	1.3	5.1	-0.9	0.1	1.4	2.2	1.9	-1.3	0.7	-0.5	0.4	1.4	-0.1	-0.6
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	4.0	-0.3	-2.0	1.6	1.6	1.7	-1.9	1.5	-0.8	0.0	0.8	1.6	0.5
Pain experienced in last month	0.3	0.5	1.6	0.9	0.5	0.2	0.5	0.4	1.3	-0.6	-0.4	1.0	-1.1	-0.7	-0.4
Supplements: Calcium	1.7	1.8	12.7	1.7	-0.4	1.3	0.5	1.2	0.3	0.0	-0.2	0.8	1.1	1.0	3.6
Basal cell carcinoma (self-reported)	0.4	0.4	1.0	0.7	0.8	-0.2	-1.0	-1.0	0.7	0.8	0.2	-0.0	-0.1	0.3	-0.8
Heart attack/myocardial infarction (self-reported)	0.3	0.3	1.7	0.0	0.6	-0.3	-0.1	-0.1	0.6	-0.1	1.3	0.1	-0.8	-0.2	-0.9
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	2.8	0.6	1.5	-0.4	-1.4	-1.0	0.8	-1.5	1.7	0.8	1.1	-0.7	1.2
Heart disease (siblings)	1.2	1.4	4.1	-1.9	-0.3	-1.6	-0.4	-0.9	-1.4	-0.2	0.3	-2.0	-1.2	-1.0	-1.1
Alcohol drinker status: Previous	0.6	0.7	3.5	-0.8	-0.2	-0.4	-1.1	1.9	-0.9	-0.2	-0.1	-0.3	0.2	-1.2	0.4
Pack years of smoking	0.3	0.4	1.6	0.3	1.2	0.2	0.3	-1.2	0.6	0.5	0.0	0.6	0.1	-0.4	0.6
Impedance of whole body	0.4	1.9	5.3	-0.9	-0.9	-1.1	0.1	1.8	0.2	-1.9	-2.3	1.2	1.6	1.7	0.6
Leg fat mass (left)	0.4	1.7	7.0	-0.4	-0.5	2.6	0.0	0.5	-0.5	2.2	1.3	0.3	2.0	-1.0	0.9
Arm predicted mass (left)	0.2	1.1	2.4	-1.5	-0.9	1.2	0.4	-0.2	-0.8	1.3	1.3	-1.1	0.6	-0.9	-1.6